CN112206365A

CN112206365A - Blood purification system and method for absorbing blood waste

Info

Publication number: CN112206365A
Application number: CN202011199040.5A
Authority: CN
Inventors: 徐军; 王何一; 方翩翩; 黄钢; 胡兆燕
Original assignee: Shanghai University of Medicine and Health Sciences
Current assignee: Shanghai University of Medicine and Health Sciences
Priority date: 2020-10-31
Filing date: 2020-10-31
Publication date: 2021-01-12

Abstract

The invention discloses a blood purification system and a method for absorbing blood waste. The input end of an ultrafiltration pump in the system is connected with a human body through a blood input pipeline, the output water of the ultrafiltration pump is connected with an ultrafiltration waste liquid collector, the output blood of the ultrafiltration pump is connected with a dosing mixed adsorber, the input end of the dosing mixed adsorber is also connected with a nano material adder, the waste liquid output end of the dosing mixed adsorber is connected with the waste liquid collector, the blood output end of the dosing mixed adsorber is connected with a purification effect detector, and the output end of the purification effect detector is connected with a blood output pipeline. The invention utilizes the characteristics of the nano material and the aggregation of toxin molecules in blood to form polymers, and utilizes the adsorbing material to filter the formed polymers again so as to achieve the aim of thoroughly removing toxins, and meanwhile, effective components such as small molecules and the like required by a human body cannot be filtered. The water quantity needing ultrafiltration is accurately controlled through the ultrafiltration pump. It is simple and convenient to operate and has good filtering effect.

Description

Blood purification system and method for absorbing blood waste

Technical Field

The invention relates to the technical field of medical instruments, in particular to a blood purification system and a blood purification method aiming at adsorbing blood wastes.

Background

Since dialysis was developed, uremic patients have become available for long-term survival. Adequate hemodialysis treatment of end-stage renal patients can reduce morbidity and mortality of complications. Adequacy of hemodialysis refers to the amount of dialysis given with morbidity and mortality associated with dialysis minimized, and is referred to as optimal dialysis or adequacy of dialysis. The currently effective treatment means for patients with renal failure before kidney transplantation is a hemodialysis method, and when the treatment method is used for treatment, the patients need to go to a hospital to use a hemodialysis machine and accessories matched with the hemodialysis machine to effectively treat the patients. The treatment method of the existing hemodialysis machine is effective, but causes great inconvenience to the work and life of patients.

A portable dialysate regeneration system for human dialysis, which is applied by Kemca technology Limited in the United states at present, has a Chinese application patent number of 200480038117.3 and an authorized publication number of CN 1897993B. The key technology of the patent is to adopt a dialysate regeneration chamber, namely a toxin interceptor capable of selectively intercepting toxins and repelling selective cations, wherein the described toxin interceptor comprises ion-selective urease-immobilized activated carbon fibers with ion-selective barriers.

Although the above method can remove creatinine and urea nitrogen in blood, the operation process and effect are not optimal, and therefore, it is important to provide a system that can remove creatinine and urea nitrogen without destroying other components in blood.

Disclosure of Invention

In view of the above-mentioned drawbacks of the prior art, the present invention provides a blood purification system and method for adsorbing blood waste, so as to solve the deficiencies of the prior art.

In order to achieve the purpose, the invention provides a blood purification system aiming at adsorbing blood wastes, which comprises an ultrafiltration pump, a dosing mixed adsorber, a nano material adder, a waste liquid collector, an ultrafiltration waste liquid collector and a purification effect detector, wherein the input end of the ultrafiltration pump is connected with a human body through a blood input pipeline, one path of water output by the ultrafiltration pump is connected with the ultrafiltration waste liquid collector, one path of blood output by the ultrafiltration pump is connected with the dosing mixed adsorber, the input end of the dosing mixed adsorber is also connected with the nano material adder, the waste liquid output end of the dosing mixed adsorber is connected with the waste liquid collector, the blood output end of the dosing mixed adsorber is connected with the purification effect detector, and the output end of the purification effect detector is connected with a blood output pipeline.

Further, it contains the casing, adds medicine hybrid chamber, pellicle and adsorption cavity to add medicine hybrid absorber, add the pellicle between medicine hybrid chamber, the adsorption cavity.

Furthermore, one path of the blood output by the ultrafiltration pump is connected with the dosing mixed adsorber through a blood purification input pipeline.

Furthermore, the input end of the dosing mixing cavity of the dosing mixing adsorber is connected with a nano-material adder.

Further, the adsorption cavity contains an adsorption material.

A method for purifying blood with the purpose of adsorbing blood waste, comprising:

blood in the human body is input into the ultrafiltration pump through a blood input pipeline to carry out water outlet operation on the blood, water which is ultrafiltered out through the ultrafiltration pump is conveyed to an ultrafiltration waste liquid collector, the blood which is ultrafiltered enters a dosing mixed adsorber through a blood purification input pipeline, meanwhile, a nano additive is injected into the dosing mixed adsorber by a nano material adder, the blood which is treated by the dosing mixed adsorber and detected by a purification effect detector is returned to the human body through a blood output pipeline to complete the blood purification process, and simultaneously, the residual participating liquid of the nano additive is recovered through the waste liquid collector.

Furthermore, the nano material adder injects nano additive into the dosing mixing cavity of the dosing mixing adsorber to mix with the input blood, then the blood added with nano additive passes through the semipermeable membrane and then is input into the filter cavity to be filtered, and the filtered toxin is retained in the adsorption cavity.

Further, the added nano additive comprises a nano material as a substrate, and cross-linked polyvinyl alcohol microspheres (CPVA) formed by polyvinyl alcohol (PVA) are added on the substrate and are used for adsorbing creatinine and urea and adjusting ion concentration and acid-base balance in blood.

The invention has the beneficial effects that:

the invention adds the nanometer additive into the medicine-adding mixed absorber through the nanometer material adder, forms the polymer by utilizing the characteristic of the nanometer material and the toxin molecule aggregation in the blood, and filters the formed polymer again by utilizing the adsorption material in the medicine-adding mixed absorber to achieve the aim of thoroughly removing the toxin, and meanwhile, effective components such as micromolecules and the like required by the human body cannot be filtered. The water quantity needing ultrafiltration is accurately controlled through the ultrafiltration pump. It is simple and convenient to operate and has good filtering effect.

The conception, the specific structure and the technical effects of the present invention will be further described with reference to the accompanying drawings to fully understand the objects, the features and the effects of the present invention.

Drawings

Fig. 1 is a schematic flow diagram of a dialysate regeneration system for portable human dialysis (chinese patent publication No. CN 1897993B).

FIG. 2 is a schematic diagram of a blood purification system for the purpose of adsorbing blood waste according to the present invention.

In fig. 2: 1-blood input line; 2-an ultrafiltration pump; 3-adding a medicine mixing adsorber; 3-1-adding medicine mixing cavity; 3-2-adsorption cavity; 4-nanomaterial addition device; 5-a waste liquid collector; 6-ultrafiltration waste liquid collector; 7-blood purification input line; 8-blood output line; 9-purification effect detector.

Detailed Description

As shown in figure 2, a blood purification system with blood waste adsorption as the purpose, including ultrafiltration pump 2, add medicine mixed adsorber 3, nano-material adder 4, waste liquid collector 5, ultrafiltration waste liquid collector 6 and purifying effect detector 9, the human body is connected through blood input pipeline 1 to ultrafiltration pump 2 input, ultrafiltration waste liquid collector 6 is connected all the way of ultrafiltration pump 2 output moisture, it adds medicine mixed adsorber 3 to connect all the way of ultrafiltration pump 2 output blood, add medicine mixed adsorber 3 input and still connect nano-material adder 4, waste liquid collector 5 is connected to the waste liquid output of medicine mixed adsorber 3, purifying effect detector 9 is connected to the blood output of medicine mixed adsorber 3, purifying effect detector 9 output connects blood output pipeline 8. Wherein, the ultrafiltration pump 5 carries out accurate control to the water yield of cleaing away as required, and purification effect detector 9 carries out blood detection according to the spectrophotometry principle.

Wherein, the drug-adding mixed absorber 3 comprises a shell, a drug-adding mixed cavity 3-1, a semi-permeable membrane and an adsorption cavity 3-2, and the semi-permeable membrane is arranged between the drug-adding mixed cavity 3-1 and the adsorption cavity 3-2. One path of the blood output by the ultrafiltration pump 2 is connected with the medicine-adding mixed absorber 3 through a blood purification input pipeline 7. The input end of a dosing mixing cavity 3-1 of the dosing mixing adsorber 3 is connected with a nano material adder 4, and an adsorption cavity 3-2 of the dosing mixing adsorber 3 contains adsorption materials, mainly composites of polyester fibers and carbon fibers, and is used for removing creatinine and urea after the polymers are synthesized.

The present invention also provides a blood purification method for the purpose of adsorbing blood waste, comprising:

blood in the human body is input into the ultrafiltration pump 2 through the blood input pipeline 1 to carry out water outlet operation on the blood, water which is ultrafiltered through the ultrafiltration pump 2 is conveyed to the ultrafiltration waste liquid collector 6, the blood which is ultrafiltered enters the dosing mixed adsorber 3 through the blood purification input pipeline 7, meanwhile, the nano-additive is injected into the dosing mixed adsorber 3 by the nano-material adder 4, the blood which is treated by the dosing mixed adsorber 3 and detected by the purification effect detector 9 is back-transfused to the human body through the blood output pipeline 8 to complete the blood purification process, and simultaneously, the participation liquid of redundant nano-additive is recovered through the waste liquid collector 5.

Wherein, the nano material adder 4 injects nano additive into the drug-adding mixing cavity 3-1 of the drug-adding mixing adsorber 3 to mix with the input blood, then the blood added with nano additive passes through the semipermeable membrane and then is input into the filter cavity to be filtered, and the filtered toxin is retained in the adsorption cavity 3-2. The added nano additive is added with small molecules and glucose which are required to be finished through diffusion.

The added nano additive comprises a nano material as a substrate, and crosslinked polyvinyl alcohol microspheres (CPVA) formed by polyvinyl alcohol PVA are added on the substrate, and the added nano additive is a water-soluble polymer with biocompatibility as a biocompatible carrier material, can form a polymer material or a polymer material with the functions of adsorbing creatinine, urea and other toxins, and is used for adsorbing creatinine, adsorbing urea, and adjusting the ion concentration and acid-base balance in blood.

In summary, the invention designs a new hemodialysis purification device, which firstly removes the redundant water in the blood completely, then adds the adsorbable nano material to the blood, enlarges the toxin molecules, and then the waste is retained in the filter through the filter device, so that the effective blood passes through the filter, and finally the blood is transported to the human body. The nano material is added into the filtering device, the waste in the blood is adsorbed and fixed by utilizing the adsorption effect of the nano material, the purified blood is then transfused into the human body, and the purifier with the waste can be discarded after being used. The invention simplifies the dialysate required in the hemodialysis process by adding the auxiliary device of the nano material, is suitable for operation in different occasions, and does not influence the work and social activities of users.

The foregoing detailed description of the preferred embodiments of the invention has been presented. It should be understood that numerous modifications and variations could be devised by those skilled in the art in light of the present teachings without departing from the inventive concepts. Therefore, the technical solutions available to those skilled in the art through logic analysis, reasoning and limited experiments based on the prior art according to the concept of the present invention should be within the scope of protection defined by the claims.

Claims

1. A blood purification system for the purpose of adsorbing blood waste, characterized in that: comprises an ultrafiltration pump (2), a drug-adding mixed absorber (3), a nano-material adder (4), a waste liquid collector (5), an ultrafiltration waste liquid collector (6) and a purification effect detector (9), the input end of the ultrafiltration pump (2) is connected with a human body through a blood input pipeline (1), one path of the water output by the ultrafiltration pump (2) is connected with an ultrafiltration waste liquid collector (6), one path of the blood output by the ultrafiltration pump (2) is connected with a medicine-adding mixed absorber (3), the input end of the drug-adding mixed absorber (3) is also connected with a nano-material adder (4), the waste liquid output end of the dosing mixed absorber (3) is connected with a waste liquid collector (5), the blood output end of the drug-adding mixed absorber (3) is connected with a purification effect detector (9), the output end of the purification effect detector (9) is connected with the blood output pipeline (8).

2. A blood purification system for the purpose of adsorbing blood waste products as claimed in claim 1, wherein: the medicine-adding mixed absorber (3) comprises a shell, a medicine-adding mixed cavity (3-1), a semi-permeable membrane and an adsorption cavity (3-2), wherein the semi-permeable membrane is arranged between the medicine-adding mixed cavity (3-1) and the adsorption cavity (3-2).

3. A blood purification system for the purpose of adsorbing blood waste products as claimed in claim 1, wherein: one path of the blood output by the ultrafiltration pump (2) is connected with the medicine-adding mixed absorber (3) through a blood purification input pipeline (7).

4. A blood purification system for the purpose of adsorbing blood waste products as claimed in claim 1, wherein: the input end of a dosing mixing cavity (3-1) of the dosing mixing absorber (3) is connected with a nano material adder (4).

5. A blood purification system for the purpose of adsorbing blood waste products as claimed in claim 1, wherein: the adsorption cavity (3-2) contains an adsorption material.

6. A method for purifying blood for the purpose of adsorbing blood waste, comprising:

blood in a human body is input into an ultrafiltration pump (2) through a blood input pipeline (1) to carry out water outlet operation on the blood, moisture ultrafiltered through the ultrafiltration pump (2) is conveyed to an ultrafiltration waste liquid collector (6), the blood after ultrafiltration enters a dosing mixed adsorber (3) through a blood purification input pipeline (7), meanwhile, a nano material adder (4) injects a nano additive into the dosing mixed adsorber (3), the blood after treatment of the dosing mixed adsorber (3) and detection of a purification effect detector (9) is reinfused to the human body through a blood output pipeline (8) to complete a blood purification process, and simultaneously, the participation liquid of redundant nano additive is recovered through the waste liquid collector (5).

7. A method for blood purification with the purpose of adsorbing blood waste as claimed in claim 6, wherein: the nano material adder (4) injects nano additive into the drug-adding mixing cavity (3-1) of the drug-adding mixing absorber (3) to mix with the input blood, then the blood added with nano additive passes through the semipermeable membrane and then is input into the filter cavity to be filtered, and the filtered toxin is retained in the adsorption cavity (3-2).

8. A method for blood purification with the purpose of adsorbing blood waste as claimed in claim 6 or 7, wherein: the added nano additive comprises a nano material as a substrate, and crosslinked polyvinyl alcohol microspheres (CPVA) formed by polyvinyl alcohol (PVA) are added on the substrate and are used for adsorbing creatinine, urea and adjusting ion concentration and acid-base balance in blood.