CN112198214A - Electrospray extraction ionization mass spectrometry detection system for new coronary pneumonia - Google Patents
Electrospray extraction ionization mass spectrometry detection system for new coronary pneumonia Download PDFInfo
- Publication number
- CN112198214A CN112198214A CN202010964965.8A CN202010964965A CN112198214A CN 112198214 A CN112198214 A CN 112198214A CN 202010964965 A CN202010964965 A CN 202010964965A CN 112198214 A CN112198214 A CN 112198214A
- Authority
- CN
- China
- Prior art keywords
- bin
- negative pressure
- detection
- bin body
- mass spectrometry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
Abstract
The invention provides an electrospray extraction ionization mass spectrometry detection system for new coronary pneumonia, which relates to the technical field of medical detection and aims to solve the technical problems of complex operation, long detection time and higher detection cost of nucleic acid detection adopted for detecting the new coronary pneumonia in the prior art, wherein the device comprises an isolation bin and a detection device connected with the isolation bin, wherein: the isolation bin comprises a bin body, one side of the bin body is provided with a bin door, and a gas transmission channel is arranged in the bin body; the detection device comprises a closed type sterilizing gas detection ion source and a mass spectrometer connected with the closed type sterilizing gas detection ion source; one end of the gas transmission channel is positioned in the bin body and is connected with the gas input end, the other end of the gas transmission channel is positioned outside the bin body, and the closed type sterilizing gas detection ion source is introduced; the mass spectrometer is connected with the terminal processing equipment, and the invention has the advantages of rapid detection, simple operation, safety and reliability.
Description
Technical Field
The invention relates to the technical field of medical detection, in particular to a new coronary pneumonia detection system.
Background
At present, the new coronary pneumonia is detected by adopting nucleic acid detection, wherein the nucleic acid detection firstly takes a saliva or throat swab sample of a patient, genetic materials in the saliva or throat swab sample are extracted, if viruses exist, the viral genetic material RNA exists in the sample, and the RNA in an extracting solution is reversely transcribed into cDNA. PCR amplification is carried out using primers specific for viral cDNA, and if a viral DNA band is amplified, it indicates that the patient has a coronavirus. If the DNA band is not amplified, the patient is judged to have no coronavirus.
The applicant has found that the prior art has at least the following technical problems:
1. the operation is complex;
2. the detection time is long;
3. the detection cost is high.
Disclosure of Invention
The invention aims to provide a new coronary pneumonia detection system to solve the technical problems of complex operation, long detection time and higher detection cost of adopting nucleic acid detection for detecting new coronary pneumonia in the prior art. The technical effects produced by the preferred technical scheme in the technical schemes provided by the invention are described in detail below.
In order to achieve the purpose, the invention provides the following technical scheme:
the invention provides a novel coronary pneumonia detection system, which comprises an isolation bin and a detection device connected with the isolation bin, wherein:
the isolation bin comprises a bin body, a bin door is arranged on one side of the bin body, and a gas transmission channel is arranged in the bin body;
the detection device comprises a closed sterilizing gas detection ion source and a mass spectrometer connected with the closed sterilizing gas detection ion source;
one end of the gas transmission channel is positioned in the bin body and is connected with a gas input end, the other end of the gas transmission channel is positioned outside the bin body, and the closed type sterilizing gas detection ion source is introduced;
the mass spectrometer is connected with terminal processing equipment.
The novel coronary pneumonia detection system provided by the invention can isolate patients to prevent cross infection and rapidly perform noninvasive sampling, can rapidly detect exhaled gas based on a mass spectrometer, can detect pneumonia only by using a small amount of reagents, has the advantages of high detection speed, capability of obtaining results within 30s, and simplicity in operation, safety and reliability.
Optionally, the closed type sterilizing gas detection ion source comprises a closed type shell, a spray head is arranged inside the shell, a circuit board is fixed inside the shell, the circuit board is arranged opposite to the spray head, a plurality of ultraviolet lamp beads are arranged on the circuit board, the spray head is fixed inside the shell through a spray head support, the spray head is connected with a connecting pipe, a heating pipe is sleeved outside the connecting pipe, and a sample in the spray head is heated through the heating pipe; the three-dimensional adjusting mechanism comprises an X-axis motor used for adjusting the position of the X axis of the spray head, a Y-axis motor used for adjusting the position of the Y axis of the spray head, a Z-axis motor used for adjusting the position of the Z axis of the spray head and a rotating shaft motor used for adjusting the angle of the spray head, and the X-axis motor, the Y-axis motor, the Z-axis motor and the rotating shaft motor are respectively connected with the spray head support.
Preferably, the storehouse body includes buffer zone and negative pressure zone, the one end of gaseous transmission passageway set up in the negative pressure zone, the buffer zone with be equipped with the negative pressure zone door between the negative pressure zone, wherein:
and the buffer area and the negative pressure area are both internally provided with a disinfection device and a fresh air system.
Adopt negative pressure district door to distinguish buffer zone and negative pressure and set up, the patient that awaits measuring gets into the negative pressure district after the buffer zone buffering and detects, and single isolation avoids cross infection, more can ensure the security of the patient that awaits measuring and the accuracy and the stability of testing result.
Preferably, the disinfection device comprises an ultraviolet lamp tube and an atomizing nozzle which are respectively arranged at the top of the buffer zone and the top of the negative pressure zone, and the atomizing nozzle is communicated with the disinfection solution through a pipeline. And ultraviolet irradiation and spraying are adopted for double disinfection, so that the safety of the internal environment of the buffer zone and the negative pressure zone is ensured.
Preferably, the new trend system includes new trend air supply system and new trend exhaust system, wherein:
fresh air supply system includes: the fresh air filtering box and the fresh air blower are sequentially connected through an air inlet pipeline;
fresh air exhaust system includes: the air exhaust device comprises an exhaust fan and an exhaust pipeline connected with the exhaust fan. Continuously send into fresh air to the internal of storehouse through setting up new trend system to at the internal pressure-fired environment that forms in storehouse, and extrude the storehouse body with the dirty air in the storehouse originally.
Preferably, the fresh air systems are arranged into two sets, the end parts of the two air inlet pipelines respectively extend into the buffer area and the negative pressure area from the top of the bin body, and the two air exhaust pipelines respectively extend out of the buffer area and the negative pressure area from the lower part of the bin body, so that the ventilation effect is good.
Preferably, the tail gas sterilization device is further included, and an air outlet of the exhaust pipeline is communicated into the tail gas sterilization device to further sterilize the tail gas, so that the gas discharged into the air is safe gas without viruses.
Preferably, the buffer area and the negative pressure area are internally provided with air suction openings, the two air suction pipelines respectively extend out of the buffer area and the negative pressure area through the air suction openings and are matched with the air suction openings, and the air suction pipelines extend out of the buffer area and the negative pressure area and then are matched with the tail gas sterilizing device to sterilize tail gas.
Preferably, the device further comprises a control system, wherein the control system comprises a control box and a man-machine intersection screen connected with the control box, the man-machine intersection screen is arranged on the side wall of the bin body, and the control box is arranged at the top end of the bin body;
door, degassing unit, new trend system, tail gas system of killing all pass through control box control, man-machine intersection screen sends the instruction of corresponding function to the control box, and the use in isolation storehouse is accomplished to the part that control box control corresponds.
Preferably, the disinfectant adopts chlorine dioxide, the chlorine dioxide is adopted to kill the new corolla pneumonitis virus efficiently, powerfully and quickly, and other viruses and fungi are also disinfected, so that the environment in the bin body is ensured to meet the use requirement.
Preferably, the isolation bin further comprises universal wheels arranged at the bottom of the bin body, the isolation bin can be moved to a required position according to use requirements by arranging the universal wheels, and the isolation bin is convenient to use and move.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without any creative effort.
FIG. 1 is a schematic structural diagram of an embodiment of an electrospray extraction ionization mass spectrometry detection system for coronary pneumonia provided by the present invention;
FIG. 2 is a schematic diagram of an exemplary embodiment of an electrospray extraction ionization mass spectrometry detection system for coronary pneumonia according to the present invention;
FIG. 3 is a schematic diagram of an internal structure of an embodiment of the electrospray extraction ionization mass spectrometry detection system for coronary pneumonia provided by the present invention;
FIG. 4 is a schematic diagram of a rear view of an electrospray extraction ionization mass spectrometry detection system for coronary pneumonia according to an embodiment of the present invention;
FIG. 5 is a schematic diagram of the electrospray extraction ionization mass spectrometry detection system for coronary pneumonia according to an embodiment of the present invention;
fig. 6 shows that the electrospray extraction ionization mass spectrometry detection system for coronary pneumonia provided by the invention is respectively used for three types of people: the fingerprint spectrogram of the exhaled gas is obtained by analyzing normal persons, negative patients and positive patients;
FIG. 7 is a flow chart of AI algorithm analysis according to the present invention.
In the figure: 1. a bin body; 2. a bin gate; 3. a closed type sterilizing gas detection ion source; 4. a mass spectrometer; 5. A terminal processing device; 7. a fresh air supply system; 8. a fresh air exhaust system; 9. a control box; 10. a man-machine intersection screen; 11. a buffer area; 12. a negative pressure region; 13. an air suction opening; 20. a universal wheel; 61. an ultraviolet lamp tube; 62. an atomizing spray head; 71. a fresh air filtering tank; 72. a fresh air blower; 73. an air inlet pipeline; 81. an exhaust fan; 82. a tail gas sterilizing device; 83. an air draft pipeline.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a new electrospray extraction ionization mass spectrometry detection system for coronary pneumonia, and fig. 1 is a schematic structural diagram of the embodiment, and as shown in fig. 1, the system comprises an isolation bin and a detection device connected with the isolation bin, in the embodiment, the isolation bin adopts a movable small isolation bin, and the technical parameters of the isolation bin refer to technical index design of a P3 laboratory, wherein:
the isolation bin comprises a bin body 1, a bin door 2 is arranged on one side of the bin body 1, the bin door 2 adopts an automatic door and is controlled by a control system, and a gas transmission channel is arranged in the bin body 1;
the detection device comprises a closed type sterilizing gas detection ion source 3 and a mass spectrometer 4 connected with the closed type sterilizing gas detection ion source 3; one end of the gas transmission channel is positioned in the bin body 1 and is connected with a gas input end, in the embodiment, the gas input end adopts a disposable blowing nozzle to prevent cross infection, the other end of the gas transmission channel is positioned outside the bin body 1 and is introduced into the closed type sterilizing gas detection ion source 3, in the embodiment, the gas transmission channel is formed by connecting a gas pipe on the bin wall of a negative pressure area 12 of the isolation bin, and the gas pipe is introduced into the closed type sterilizing gas detection ion source 3 from the negative pressure area 12; the mass spectrometer 4 is connected to a terminal processing device 5, and in this embodiment, the terminal processing device is a computer.
Optionally, the closed type sterilizing gas detection ion source comprises a closed type shell, a spray head is arranged inside the shell, a circuit board is fixed inside the shell, the circuit board is arranged opposite to the spray head, a plurality of ultraviolet lamp beads are arranged on the circuit board, the spray head is fixed inside the shell through a spray head support, the spray head is connected with a connecting pipe, a heating pipe is sleeved outside the connecting pipe, and a sample in the spray head is heated through the heating pipe;
optionally, a three-dimensional adjusting mechanism is disposed in the housing, the three-dimensional adjusting mechanism includes an X-axis motor for adjusting a position of the X-axis of the nozzle, a Y-axis motor for adjusting a position of the Y-axis of the nozzle, a Z-axis motor for adjusting a position of the Z-axis of the nozzle, and a rotation axis motor for adjusting an angle of the nozzle, and the X-axis motor, the Y-axis motor, the Z-axis motor, and the rotation axis motor are respectively connected to the nozzle support.
When the device is used, the movable small isolation bin is firstly opened and disinfected, then the mass spectrometer 4 is opened, the closed type sterilizing gas detection ion source 3 is adjusted, a patient to be detected enters the isolation bin and blows air into the closed type sterilizing gas detection ion source 3 through a gas transmission channel on the isolation bin, the mass spectrometer 4 is connected with carrier gas such as nitrogen and an extractant reagent through another sample inlet, the selected extractant reagent can be a mixture of methanol and water, the volume ratio is preferably 1:1, the patient to be detected finishes blowing air and leaves the isolation bin to sterilize the isolation bin, a spectrogram is obtained through the mass spectrometer 4, and a detector processes spectrogram data through a computer and analyzes whether the exhaled air has characteristics of metabolites such as pneumonia or not, so that the patient can know whether pneumonia exists or not. The system can isolate patients and perform quick noninvasive sampling, can quickly detect expired gas based on a mass spectrometer, can detect pneumonia only by using a small amount of reagents, and has the advantages of high detection speed, simplicity in operation and low cost.
As an optional implementation manner, fig. 2 is a schematic front view structure diagram of the present embodiment, as shown in fig. 2, the bin body 1 includes a buffer area 11 and a negative pressure area 12, one end of the gas transmission channel is disposed in the negative pressure area 12, a negative pressure area door is disposed between the buffer area 11 and the negative pressure area 12, the negative pressure area door also adopts an automatic door, and is controlled by a control system, wherein:
all be equipped with degassing unit and new trend system in buffer 11 and the negative pressure zone 12, adopt the negative pressure zone door to separately set up buffer 11 and negative pressure zone 12, the patient that awaits measuring gets into negative pressure zone 12 after buffer 11 cushions and detects, single isolation avoids cross infection, more can ensure the security of the patient that awaits measuring and the accuracy and the stability of detecting the result.
As an alternative embodiment, fig. 3 is a schematic diagram of the internal structure of this embodiment, and as shown in fig. 3, the disinfecting device includes an ultraviolet lamp 61 and an atomizing nozzle 62 respectively disposed at the top of the buffer zone 11 and the top of the negative pressure zone 12, in this embodiment, the ultraviolet lamp 61 and the atomizing nozzle 62 are controlled by the control system to automatically disinfect, the atomizing nozzle 62 is communicated with the disinfecting liquid through a pipeline, the ultraviolet lamp 61 of the buffer zone 11 irradiates the patient after leaving the buffer zone 11, and the atomizing nozzle 62 is adopted to spray disinfection medicine to carry out powerful disinfection and killing on the virus, after the isolated patient leaves the negative pressure region 12, the ultraviolet lamp tube 61 of the negative pressure zone 12 irradiates, the atomizing nozzle 62 sprays disinfection medicine to carry out powerful disinfection on viruses, and the ultraviolet irradiation and the spraying are adopted to carry out double disinfection, so that the safety of the internal environment of the buffer zone 11 and the negative pressure zone 12 is ensured.
Preferably, the disinfection solution is chlorine dioxide, which has strong killing capacity on bacteria, viruses and fungal spores, and is used for efficiently, powerfully and quickly killing the new coroneumoniae virus and disinfecting other viruses and fungi, so that the environment in the bin body 1 can meet the use requirements.
As optional implementation mode, fig. 4 is a schematic diagram of the rear view structure of this embodiment, as shown in fig. 4, the fresh air system includes a fresh air supply system 7 and a fresh air exhaust system 8, and the fresh air system continuously supplies fresh air to the cabin body, and forms a micro-positive pressure environment in the cabin body, and extrudes the originally dirty air in the cabin body out of the cabin body, wherein:
the fresh air supply system 7 comprises a fresh air filter box 71 and a fresh air supply blower 72, and an air supply pipeline 73 is sequentially connected with the fresh air filter box 71 and the fresh air supply blower 72;
fresh air exhaust system 8 includes: an air blower 81 and an air suction line 83 connected to the air blower 81.
Specifically, the fresh air systems are provided in two sets, the end portions of the two air inlet pipelines 73 respectively extend into the buffer region 11 and the negative pressure region 12 from the top of the bin body 1, and the two air exhaust pipelines 83 respectively extend out of the buffer region 11 and the negative pressure region 12 from the lower portion of the bin body 1.
As an optional implementation manner, the exhaust gas disinfection device 82 is further included, and an air outlet of the exhaust pipeline 83 is communicated into the exhaust gas disinfection device 82 to further disinfect the exhaust gas, so that the gas discharged into the air is ensured to be safe gas without viruses.
As an alternative embodiment, the buffer area 11 and the negative pressure area 12 are both provided with the suction opening 13, and the two suction pipes 83 respectively extend out of the buffer area 11 and the negative pressure area 12 through the suction opening 13.
As an optional embodiment, the isolation bin also comprises a universal wheel 20 arranged at the bottom of the bin body 1, and the isolation bin can be moved to a required position according to use requirements by arranging the universal wheel 20, so that the isolation bin is convenient to use and move.
As an optional implementation mode, the isolation cabin further comprises a control system, the control system comprises a control box 9 and a man-machine intersection screen 10 connected with the control box 9, the man-machine intersection screen 10 is arranged on the side wall of the cabin body 1, the control box 9 is arranged at the top end of the cabin body 1, a worker clicks the function on the man-machine intersection screen 10, the man-machine intersection screen 10 sends the instruction of the corresponding function to the control box 9, and the control box 9 controls the corresponding component to complete the use of the isolation cabin.
Fig. 5 is a working schematic diagram of the embodiment, and as shown in fig. 5, the bin door 2, the negative pressure region door, the sterilizing device, the fresh air supply system 7, the fresh air exhaust system 8 and the tail gas sterilizing device 82 are all controlled by the control box 9.
The working process of the invention is as follows:
1. the movable small isolation bin is moved to a proper position, the isolation bin is electrified, the air exhaust system starts to work, the automatic door is closed, the isolation bin maintains the pressure of the buffer zone lower than the external 40Pa, the negative pressure zone 12 maintains the pressure of the buffer zone lower than the external 60Pa, and the tail gas sterilizing device 82 starts to work.
2. Opening the man-machine intersection screen 10, and double-clicking the isolation bin opening control software to enter a man-machine intersection interface;
3. and clicking 'disinfection' in a man-machine intersection interface, opening an ultraviolet lamp in the isolation bin, and starting spraying and disinfecting for 30 seconds.
4. After killing is finished, clicking 'enter a buffer zone' in a human-computer intersection interface, automatically opening the door 2, enabling a patient needing isolation to enter the buffer zone 11, and waiting for 6 seconds to automatically close the door after opening the door 2.
5. After the negative pressure of the buffer area 11 is stabilized, clicking 'enter the negative pressure area' in the man-machine intersection interface, automatically opening the negative pressure area door, enabling a patient needing to be isolated to enter the negative pressure area 12 for isolation, and waiting for 6 seconds to automatically close the door after opening the negative pressure area door.
6. 5 seconds after the patient needing isolation enters the negative pressure zone 12, the buffer zone 11 automatically turns on the ultraviolet lamp and sprays to sterilize, and the safety of the buffer zone 11 is ensured.
7. After entering the negative pressure region 12, the isolated patient blows air against a disposable mouthpiece in the chamber body, and the air exhaled by the patient enters the closed type killing ion source through an air transmission channel on the isolation chamber;
8. obtaining a spectrogram through a mass spectrometer 4;
9. and (4) blowing the patient to be detected, leaving the isolation bin, disinfecting the isolation bin, and processing spectrogram data by the detector to obtain a result.
The following describes a detection application example of the novel electrospray extraction ionization mass spectrometry detection system (EESI-MS) for coronary pneumonia provided by the invention.
1) Detection process
During detection, a test object enters the negative pressure region 12 (with a mask) to wait, enters the buffer region 11 after the buffer region 11 is sterilized (low negative pressure, delta P is-40 Pa, the mask is worn), and enters the negative pressure region 12 after pressure balance (low negative pressure, delta P is-60 Pa). After the pressure in the negative pressure region 12 is balanced, the breathing is adjusted, the mask is taken off, the exhalation detection is carried out by using the disposable mouthpiece, the gas exhaled by the detection object enters the closed type killing ion source through the gas transmission channel on the isolation bin, and then enters the mass spectrum to begin to collect the fingerprint spectrogram of the exhaled gas. After the blowing is finished, the disposable blowing nozzle is taken down and placed at a blowing nozzle collecting position which is specially used for collecting, and the user wears the mask and leaves. After the bin gate is closed, the whole negative pressure bin body is sprayed and disinfected by the ultraviolet lamp and the chlorine dioxide in a spraying mode comprehensively, and the next test is carried out after disinfection is finished.
2) Sample analysis
Analyzing the exhaled gas obtained in the step 1), wherein the exhaled gas consists of a plurality of complex molecules, and the difference between the types and the content of the molecules forms the molecular fingerprint of the exhaled gas sample. The electrospray extraction ionization mass spectrometry detection system for coronary pneumonia provided by the invention is used for directly analyzing the exhaled gas samples of normal people, patients with positive nucleic acid detection and negative patients, and primary mass spectrometry fingerprint spectrograms of different samples are obtained, as shown in fig. 6. As can be seen by comparing the primary fingerprints of the three groups of samples, the main mass spectrum peaks are similar among normal persons, positive patients and negative patients, including m/z 59 (acetone), m/z 193 (citric acid ), m/z 61 (urea), m/z 114(creatinine ), m/z 74(N, N-dimethylformamide, N, N-dimethylformamide), m/z 60(trimethylamine ), m/z 74 (N-isopyropylmethylamine, N-isopropylamine), m/z 79 (dimethylsulphoxide, dimethyl sulfoxide), m/z 88(N, N-dimethylacetamide, N, N-dimethylacetamide) and the like.
3) Determination of results
As shown in fig. 7, the detection result data are compared and distinguished by 5 different artificial intelligence means and algorithms respectively; the five algorithms are respectively: the support vector machine, the random forest, the naive Bayes, the multilayer neural network and the TensorFlow are all the existing mature algorithms with high reliability, if the results respectively judged by 4 or 5 methods indicate that the molecular fingerprint of the exhaled gas sample of the detected person accords with the fingerprint characteristics of the exhaled gas of the new coronary virus infected person, the patient is judged to be a new coronary virus pneumonia patient, namely positive; if 3 or more than 3 judgment results are not considered to be in accordance with the characteristics of the patient with the new coronavirus pneumonia, judging that the patient is a person infected by the non-new coronavirus, namely, judging that the patient is negative; otherwise, the patient is suspected to have the new coronavirus pneumonia.
By applying the novel electrospray extraction ionization mass spectrometry detection system for coronary pneumonia provided by the invention, the detection results of throat swab nucleic acid detection and the method are compared on 205 detection objects in the first subsidiary hospital of Nanchang university, the coincidence rate reaches 95.2%, and the accuracy is very high.
The isolation bin of the detection system is movable, negative pressure isolation is adopted, ultraviolet irradiation and spraying are carried out in a double-sterilization mode, a single person is isolated, cross infection is avoided, the mobile small isolation bin is small in occupied area, detection can be carried out at any time quickly, cleaning is convenient, pollution is avoided, the detection result only needs 30s, and the detection efficiency is greatly improved by comparing the detection result with the nucleic acid detection result which is obtained in a few hours.
The above description is only for the specific embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (10)
1. The electrospray extraction ionization mass spectrum detection system for the new coronary pneumonia is characterized in that: the device comprises an isolation bin and a detection device connected with the isolation bin, wherein:
the isolation bin comprises a bin body, a bin door is arranged on one side of the bin body, and a gas transmission channel is arranged in the bin body;
the detection device comprises a closed type sterilizing gas detection ion source and a mass spectrometer connected with the closed type sterilizing gas detection ion source;
one end of the gas transmission channel is positioned in the bin body and is connected with a gas input end, the other end of the gas transmission channel is positioned outside the bin body, and the closed type sterilizing gas detection ion source is introduced;
the mass spectrometer is connected with terminal processing equipment.
2. The electrospray extraction ionization mass spectrometry detection system for neocoronary pneumonia of claim 1, wherein: the storehouse body includes buffer and negative pressure zone, the one end of gas transmission passageway set up in the negative pressure zone, the buffer with be equipped with the negative pressure zone door between the negative pressure zone, wherein:
and the buffer area and the negative pressure area are both internally provided with a disinfection device and a fresh air system.
3. The electrospray extraction ionization mass spectrometry detection system for neocoronary pneumonia of claim 2, wherein: the disinfection device comprises an ultraviolet lamp tube and an atomizing nozzle which are respectively arranged at the top of the buffer zone and the top of the negative pressure zone, and the atomizing nozzle is communicated with the disinfectant through a pipeline.
4. The electrospray extraction ionization mass spectrometry detection system for neocoronary pneumonia of claim 3, wherein: the new trend system includes new trend air supply system and new trend exhaust system, wherein:
fresh air supply system includes: the fresh air filtering box and the fresh air blower are sequentially connected through an air inlet pipeline;
fresh air exhaust system includes: the air exhaust device comprises an exhaust fan and an exhaust pipeline connected with the exhaust fan.
5. The electrospray extraction ionization mass spectrometry detection system for neocoronary pneumonia of claim 4, wherein: the fresh air system is provided with two sets, the end parts of the two air inlet pipelines respectively extend into the buffer area and the negative pressure area from the top of the bin body, and the two air exhaust pipelines respectively extend out of the buffer area and the negative pressure area from the lower part of the bin body.
6. The electrospray extraction ionization mass spectrometry detection system for new coronary pneumonia according to claim 4 or 5, characterized in that: the tail gas sterilization device is further included, and an air outlet of the air exhaust pipeline is communicated into the tail gas sterilization device.
7. The electrospray extraction ionization mass spectrometry detection system for neocoronary pneumonia of claim 6, wherein: and air suction ports are arranged in the buffer area and the negative pressure area, and the two air suction pipelines respectively extend out of the buffer area and the negative pressure area through the air suction ports.
8. The electrospray extraction ionization mass spectrometry detection system for neocoronary pneumonia of claim 7, wherein: the control system comprises a control box and a man-machine intersection screen connected with the control box, the man-machine intersection screen is arranged on the side wall of the bin body, and the control box is arranged at the top end of the bin body;
the bin gate, the sterilizing device, the fresh air system and the tail gas sterilizing system are all controlled by the control box.
9. The electrospray extraction ionization mass spectrometry detection system for neocoronary pneumonia of claim 3, wherein: the disinfectant adopts chlorine dioxide.
10. The electrospray extraction ionization mass spectrometry detection system for neocoronary pneumonia of claim 1, wherein: the isolation bin further comprises universal wheels arranged at the bottom of the bin body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010964965.8A CN112198214A (en) | 2020-09-15 | 2020-09-15 | Electrospray extraction ionization mass spectrometry detection system for new coronary pneumonia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010964965.8A CN112198214A (en) | 2020-09-15 | 2020-09-15 | Electrospray extraction ionization mass spectrometry detection system for new coronary pneumonia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112198214A true CN112198214A (en) | 2021-01-08 |
Family
ID=74014914
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010964965.8A Pending CN112198214A (en) | 2020-09-15 | 2020-09-15 | Electrospray extraction ionization mass spectrometry detection system for new coronary pneumonia |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112198214A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022166487A1 (en) * | 2021-02-04 | 2022-08-11 | 北京毅新博创生物科技有限公司 | Use of characteristic polypeptide composition and mass spectrometry model for preparing covid-19 detection product |
| WO2022166493A1 (en) * | 2021-02-04 | 2022-08-11 | 北京毅新博创生物科技有限公司 | Mass spectrometry model comprising marker polypeptides for diagnosing covid-19 pneumonia |
-
2020
- 2020-09-15 CN CN202010964965.8A patent/CN112198214A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022166487A1 (en) * | 2021-02-04 | 2022-08-11 | 北京毅新博创生物科技有限公司 | Use of characteristic polypeptide composition and mass spectrometry model for preparing covid-19 detection product |
| WO2022166493A1 (en) * | 2021-02-04 | 2022-08-11 | 北京毅新博创生物科技有限公司 | Mass spectrometry model comprising marker polypeptides for diagnosing covid-19 pneumonia |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20220034854A1 (en) | Diagnosis of tuberculosis and other diseases using exhaled breath | |
| CN112198214A (en) | Electrospray extraction ionization mass spectrometry detection system for new coronary pneumonia | |
| CN104271199B (en) | Harl decontamination mechanism and its operating method | |
| EP4125569A1 (en) | Diagnosis of respiratory diseases using analysis of exhaled breath and aerosols | |
| CN104287735A (en) | Respiratory monitoring and breath analysis system | |
| CN111011221A (en) | High-grade biological safety protection type small and medium animal pathogen air transmission experimental device | |
| CN213209991U (en) | Electrospray extraction ionization mass spectrometry detection system for new coronary pneumonia | |
| CN108624491B (en) | Movable PCR laboratory | |
| US20210315483A1 (en) | Method for Obtaining a Breath Sample of a Test Person and Device | |
| CN112246290A (en) | Air purification type integrated experiment cabinet and working method thereof | |
| CN107519730A (en) | Device for processing laboratory waste gas | |
| CN109001445A (en) | A kind of exhaled gas detection reaction unit for lung cancer | |
| Ouyang et al. | Single-pass wind tunnel testing for recirculating virus aerosol control technologies | |
| Chen et al. | Development of a portable bioaerosol capture device for influenza virus detection | |
| KR101119594B1 (en) | The system and method for measuring exhalation of pulmonary disease patient | |
| CN113899050B (en) | Air curtain space barrier device and system based on airflow dynamics model | |
| CN111011229A (en) | High-grade biological safety protection type medium and large animal pathogen air transmission experimental device | |
| CN110934589A (en) | Respiratory virus detection device and detection method | |
| US20240148274A1 (en) | Diagnosis of respiratory diseases by capturing aerosolized biomaterial particles using packed bed systems and methods | |
| CN105286993B (en) | A kind of scalpel system with detector | |
| CN214949620U (en) | Positive pressure sampling room | |
| CN212538176U (en) | Dual-purpose ventilation system PCR laboratory | |
| KR102458388B1 (en) | Multifunctional booth for mobile specimen collection | |
| WO2023064348A1 (en) | Diagnosis of tuberculosis and other diseases using exhaled breath | |
| CN218742026U (en) | Gas volatilization detection and analysis biological safety cabinet |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20220614 Address after: Room 301, floor 3, building 1, yard 19, Jiaomen, Fengtai District, Beijing 100068 Applicant after: Beijing AVIC Baofu Technology Co.,Ltd. Address before: 330013 No. 418, Guanglan Avenue, Qingshanhu District, Nanchang City, Jiangxi Province Applicant before: EAST CHINA INSTITUTE OF TECHNOLOGY |