CN112168985A - Pre-filling needle sterilization production line and production method - Google Patents
Pre-filling needle sterilization production line and production method Download PDFInfo
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- CN112168985A CN112168985A CN202011079584.8A CN202011079584A CN112168985A CN 112168985 A CN112168985 A CN 112168985A CN 202011079584 A CN202011079584 A CN 202011079584A CN 112168985 A CN112168985 A CN 112168985A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
- A61L2/06—Hot gas
- A61L2/07—Steam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/26—Accessories or devices or components used for biocidal treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/14—Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
Abstract
The invention discloses a pre-filling needle sterilization production line, wherein an inlet and an outlet of a sterilization box are respectively and correspondingly provided with a steam inlet pipeline and a steam exhaust pipeline, the steam inlet pipeline of the sterilization box is provided with a steam inlet valve, the steam exhaust pipeline is provided with a steam exhaust valve, and the steam inlet pipeline can be used for filling high-temperature steam and clean air into the sterilization box. When the pressure of the inner chamber of the sterilization box is smaller than the preset pressure of the pre-filling needle, the opening degree of the steam inlet valve is increased, the opening degree of the steam exhaust valve is reduced, and the sterilization box is filled with steam and pressurized; when the pressure of the inner chamber is greater than the preset pressure, the opening of the steam inlet valve is reduced, the opening of the steam exhaust valve is increased, and the steam exhaust of the sterilization box is depressurized; when the pressure of the inner chamber is equal to the preset pressure, the opening degrees of the steam inlet valve and the steam exhaust valve are kept unchanged, so that the opening degree of the steam inlet valve is adjusted according to the preset pressure of the pre-filling needle, the pressure of the inner chamber of the sterilization box is adjusted by changing the mixing proportion of high-temperature steam and clean air of the sterilization box until the pressure of the inner chamber is consistent with the preset pressure, and the pre-filling needle can be effectively kept from deforming before and after sterilization. The invention also discloses a production method for sterilizing the pre-filling needle.
Description
Technical Field
The invention relates to the technical field of pharmacy, in particular to a pre-filling needle sterilization production line. The invention also relates to a production method of the pre-filling needle.
Background
The pre-filling needle has good safety and convenience, so that the pre-filling needle is popular. In the pharmaceutical field, optimizing the filling process of the pre-filling needle is a key factor for improving the production quality of the pre-filling needle, so that the optimization of the filling process of the pre-filling needle is particularly necessary.
The pre-filling needle generally comprises a plunger, a syringe and a protective cap, the protective cap is mounted at the needle head of the syringe, the plunger is slidably mounted in the syringe, the plunger and the protective cap form a sealed cavity in the syringe, and the sealed cavity is used for containing a certain volume of liquid medicine. The filling process of the pre-filling needle theoretically adopts high-temperature steam for sterilization, and in the sterilization process, the pressure of the inner chamber of the sterilization box and the pressure of the sealing cavity of the pre-filling needle keep dynamic balance. However, in the actual production process, the number of the pre-filling needles sterilized in the same batch is large, and the storage amount, the liquid volume and the gas volume of different pre-filling needles are different, so that the prior art is difficult to uniformly and dynamically control the balance of the internal pressure and the external pressure of all the pre-filling needles, so that the pre-filling needles are frequently subjected to the problem of explosion, the product reject ratio is high, and the pre-filling needles are difficult to keep not deformed before and after sterilization.
Disclosure of Invention
In view of the above, an object of the present invention is to provide a pre-filling needle sterilization production line, in which an opening degree of an inlet valve and an outlet valve is adjusted according to a preset pressure of a pre-filling needle, and an inner chamber pressure of a sterilization chamber is adjusted by changing a mixing ratio of high-temperature steam and clean air in the sterilization chamber, so that the inner chamber pressure is kept consistent with the preset pressure, and the pre-filling needle is kept from being deformed before and after sterilization. The invention also aims to provide a production method for sterilizing the pre-filled needle.
The specific scheme is as follows:
the invention provides a pre-filling needle sterilization production line, which comprises:
the inlet and the outlet of the sterilization box are respectively provided with an inlet pipeline and an outlet pipeline correspondingly, the inlet pipeline is provided with an inlet valve, the outlet pipeline is provided with an outlet valve, the inlet pipeline is used for filling high-temperature steam and clean air into the sterilization box, and the inlet valve and the outlet valve are used for correspondingly adjusting the opening degree of the inlet valve and the outlet valve according to the preset pressure of the pre-filling needle so as to adjust the pressure of the inner chamber of the sterilization box until the pressure of the inner chamber is consistent with the preset pressure by changing the mixing proportion of the high-temperature steam and the clean air in the sterilization box.
Preferably, the sterilization box further comprises a steam mixing box connected between the sterilization box and the steam inlet pipeline, the steam inlet pipeline comprises a steam inlet pipeline and an air inlet pipeline which are respectively arranged at an inlet of the steam mixing box, the steam inlet valve comprises a steam inlet valve arranged on the steam inlet pipeline and an air inlet valve arranged on the air inlet pipeline, an outlet of the steam mixing box is provided with a steam exhaust and mixing valve, and the steam exhaust and mixing valve, the steam inlet valve and the air inlet valve correspondingly adjust the opening degree thereof according to the preset pressure and the sterilization temperature so as to adjust the inner chamber pressure and the inner chamber temperature of the sterilization box by adjusting the mixing proportion of high-temperature steam and clean air in the steam mixing box until the inner chamber pressure is consistent with the preset pressure and the inner chamber temperature is consistent with the sterilization temperature.
Preferably, the sterilization device further comprises a transition valve arranged between the steam mixing box and the sterilization box, and when the temperature of the inner chamber is consistent with the sterilization temperature, the transition valve adjusts the opening degree of the transition valve according to the preset pressure so as to adjust the mixing proportion of the high-temperature steam and the clean air filled into the sterilization box by the steam mixing box until the pressure of the inner chamber is consistent with the preset pressure.
Preferably, the method further comprises the following steps:
the sterilization pressure detection piece is arranged in the sterilization box and used for detecting the pressure of the sterilization box to obtain the pressure of the inner chamber;
the sterilization temperature detection piece is arranged in the sterilization box and used for detecting the temperature of the sterilization box so as to obtain the temperature of the inner chamber;
the controller is respectively connected with the transition valve, the steam exhaust valve, the sterilization pressure detection piece and the sterilization temperature detection piece;
the controller is used for simultaneously adjusting the opening degrees of the transition valve and the exhaust valve according to signals simultaneously sent by the sterilization pressure detection piece and the sterilization temperature detection piece when the pressure of the inner chamber is inconsistent with the preset pressure and the temperature of the inner chamber is inconsistent with the sterilization temperature so as to proportionally charge high-temperature steam and clean air into the sterilization box until the pressure of the inner chamber is consistent with the preset pressure and the temperature of the inner chamber is consistent with the sterilization temperature.
Preferably, the method further comprises the following steps:
the mixed steam pressure detection piece is arranged in the mixed steam box and used for detecting the pressure of the mixed steam box to obtain mixed steam pressure; the controller is used for adjusting the opening degrees of the exhaust mixing valve, the steam inlet pipeline and the air inlet pipeline according to signals sent by the mixed steam pressure detection part when the mixed steam pressure is inconsistent with the specified pressure so as to adjust the mixed steam pressure until the mixed steam pressure is consistent with the specified pressure.
Preferably, the method further comprises the following steps:
the mixed steam temperature detection piece is arranged in the mixed steam box and used for detecting the temperature of the mixed steam box to obtain the mixed steam temperature; the mixed steam temperature detection part is connected with the controller, and the controller is used for adjusting the opening degrees of the exhaust mixed steam valve, the steam inlet pipeline and the air inlet pipeline according to signals sent by the mixed steam temperature detection part when the mixed steam temperature is inconsistent with the specified temperature so as to adjust the mixed steam temperature until the mixed steam temperature is consistent with the specified temperature.
Preferably, the method further comprises the following steps:
locate the sterilization incasement and be used for detecting the sterilization humidity detection piece of sterilization case humidity, the sterilization humidity detection piece links to each other with the controller, and the controller is used for being greater than the steam exhaust valve of presetting sterilization humidity control and opening in order to discharge the comdenstion water at sterilization case humidity according to the signal that sterilization humidity detection piece sent.
Preferably, the device also comprises a transfer trolley arranged in the sterilization box, and the transfer trolley is provided with a tray for supporting the pre-filling needle.
The pre-filling needle sterilization production method provided by the invention is based on any one of the pre-filling needle sterilization production lines, and is characterized by comprising the following steps of:
judging whether the pressure of the inner chamber of the sterilization box is consistent with the preset pressure of the pre-filling needle or not, if so, keeping the opening degree of the steam inlet valve unchanged; if not, the opening of the steam inlet valve is adjusted according to the preset pressure so as to adjust the pressure of the inner chamber of the sterilization box by changing the mixing proportion of the high-temperature steam and the clean air in the sterilization box until the pressure of the inner chamber is consistent with the preset pressure.
Compared with the background art, the pre-filling needle sterilization production line provided by the invention has the advantages that the inlet and the outlet of the sterilization box are respectively and correspondingly provided with the steam inlet pipeline and the steam exhaust pipeline, the steam inlet pipeline of the sterilization box is provided with the steam inlet valve, the steam exhaust pipeline is provided with the steam exhaust valve, the steam inlet pipeline can be used for filling high-temperature steam and clean air into the sterilization box, when the pressure of the inner chamber of the sterilization box is smaller than the preset pressure of the pre-filling needle, the opening degree of the steam inlet valve is increased, the opening degree of the exhaust valve is reduced at the same time, the proportion of the high-temperature steam in the sterilization box is improved, and the sterilization box is pressurized until the pressure; when the pressure of the inner chamber of the sterilization box is greater than the preset pressure of the pre-filling needle, the opening degree of the steam inlet valve is reduced, the opening degree of the exhaust valve is increased, the proportion of high-temperature steam in the sterilization box is reduced, and the sterilization box is depressurized until the pressure of the inner chamber is consistent with the preset pressure; when the pressure of the inner chamber of the sterilization box is equal to the preset pressure of the pre-filling needle, the opening degrees of the steam inlet valve and the steam exhaust valve are kept unchanged, so that the pressure of the inner chamber is kept consistent with the preset pressure. Therefore, the opening degrees of the steam inlet valve and the steam outlet valve are adjusted according to the preset pressure of the pre-filling needle, so that the pressure of the inner chamber of the sterilization box is adjusted by changing the mixing proportion of the high-temperature steam and the clean air of the sterilization box until the pressure of the inner chamber is consistent with the preset pressure, and the pre-filling needle can be effectively kept not to deform before and after sterilization.
The technical scheme of the pre-filling needle sterilization production method provided by the invention is essentially the same as that of the pre-filling needle sterilization production line provided by the invention, so that the pre-filling needle sterilization production method has the same beneficial effects.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
FIG. 1 is a diagram illustrating the connection of components of a pre-filled needle sterilization line according to an embodiment of the present invention.
The reference numbers are as follows:
a pre-filling needle 01;
the device comprises a sterilization box 1, a steam inlet pipeline 21, an air inlet pipeline 22, a steam exhaust pipeline 3, a steam inlet valve 41, an air inlet valve 42, a steam exhaust valve 5, a steam mixing box 6, a steam exhaust and mixing valve 7, a transition valve 8, a steam mixing pressure detection piece 9 and a steam mixing temperature detection piece 10;
a trolley 11 and a pallet 12.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In order that those skilled in the art will better understand the disclosure, the invention will be described in further detail with reference to the accompanying drawings and specific examples.
Referring to fig. 1, fig. 1 is a connection diagram of components of a pre-filling needle sterilization production line according to an embodiment of the present invention.
The embodiment of the invention discloses a pre-filling needle sterilization production line which comprises a sterilization box 1, wherein the sterilization temperature of the sterilization box 1 during sterilization can be determined according to the properties of articles to be sterilized. The sterilization box 1 has good sealing performance, so that the sterilization box 1 can keep stable temperature and pressure in the sterilization process. The specific structure and working principle of the sterilization box 1 can refer to the prior art.
The sterilizing box 1 is internally provided with a transfer trolley 11, the transfer trolley 11 is provided with trays 12, the trays 12 are arranged layer by layer, each layer of tray 12 is provided with a pre-filling needle 01, and the pre-filling needles 01 are sterilized in batches. The bottom of the transfer trolley 11 is provided with rollers, so that the pre-filling needle 01 is convenient to transfer.
An inlet and an outlet of the sterilization box 1 are respectively and correspondingly provided with a steam inlet pipeline and a steam exhaust pipeline 3, the steam inlet pipeline is filled with mixed steam formed by mixing high-temperature steam and clean air from the inlet of the sterilization box 1, and the steam exhaust pipeline 3 is used for exhausting the mixed steam from the outlet of the sterilization box 1. The steam inlet pipeline is provided with a steam inlet valve, the steam exhaust pipeline 3 is provided with a steam exhaust valve 5, and the opening degrees of the steam inlet valve and the steam exhaust valve 5 are adjustable.
When the pressure of the inner chamber of the sterilization box 1 is lower than the preset pressure of the pre-filling needle 01, the opening degree of the steam inlet valve is increased, the opening degree of the steam exhaust valve 5 is decreased, the proportion of high-temperature steam in the sterilization box 1 is increased, and the sterilization box 1 is pressurized until the pressure of the inner chamber is consistent with the preset pressure; when the pressure of the inner chamber of the sterilization box 1 is greater than the preset pressure of the pre-filling needle 01, the opening degree of the steam inlet valve 1 is reduced, the opening degree of the steam outlet valve 5 is increased, the proportion of high-temperature steam in the sterilization box 1 is reduced, and the sterilization box 1 is depressurized until the pressure of the inner chamber is consistent with the preset pressure; when the pressure of the inner chamber of the sterilization box 1 is equal to the preset pressure of the pre-filling needle 01, the opening degrees of the steam inlet valve and the steam exhaust valve 5 are kept unchanged, so that the pressure of the inner chamber is kept consistent with the preset pressure.
In summary, the pre-filling needle sterilization production line provided by the present invention can correspondingly adjust the opening degree of the steam inlet valve and the steam outlet valve 5 according to the preset pressure of the pre-filling needle, so as to adjust the internal chamber pressure of the sterilization box 1 by changing the mixing ratio of the high-temperature steam and the clean air in the sterilization box until the internal chamber pressure is consistent with the preset pressure, and can effectively keep the pre-filling needle from deforming before and after sterilization.
The steam mixing box 6 is connected between the sterilization box 1 and the steam inlet pipeline, the steam mixing box 6 has a buffering function, the temperature of the sterilization box 1 is prevented from exceeding the sterilization temperature due to the fact that steam is filled, and safety is high. The steam inlet pipeline comprises a steam inlet pipeline 21 and an air inlet pipeline 22, the steam inlet pipeline 21 and the air inlet pipeline 22 are connected with an inlet of the steam mixing box 6, the steam inlet pipeline 21 is used for filling high-temperature steam into the steam mixing box 6, the air inlet pipeline 22 is used for filling clean air into the steam mixing box 6, the high-temperature steam and the clean air are filled into the steam mixing box 6 in proportion, and the steam mixing box 6 can fill the mixed steam into the sterilizing box 1. It should be noted that the mixing ratio of the high-temperature steam and the clean air is mainly determined by the sterilization temperature of the sterilization chamber 1.
The steam inlet valve comprises a steam inlet valve 41 and an air inlet valve 42, the steam inlet pipeline 21 is provided with the steam inlet valve 41, the air inlet pipeline 22 is provided with the air inlet valve 42, and the outlet of the steam mixing box 6 is provided with the exhaust steam mixing valve 7. The opening degrees of the exhaust steam mixing valve 7, the steam inlet valve 41 and the air inlet valve 42 are all adjustable.
When the inner chamber pressure of the sterilization box 1 is inconsistent with the preset pressure and the inner chamber temperature is inconsistent with the sterilization temperature, the opening degrees of the exhaust steam mixing valve 7, the steam inlet valve 41 and the air inlet valve 42 are simultaneously adjusted, so that the mixing proportion of high-temperature steam and clean air in the steam mixing box 6 is adjusted, the temperature and the pressure of mixed gas in the steam mixing box 6 are changed, the temperature and the pressure of the mixed gas filled into the sterilization box 1 in the steam mixing box 6 are further adjusted, the inner chamber pressure of the sterilization box 1 is consistent with the preset pressure, the inner chamber temperature is consistent with the sterilization temperature, and the sterilization box 1 is kept in a sterilization state for a long time.
Specifically, when the pressure of the inner chamber is lower than the preset pressure and the temperature of the inner chamber is lower than the sterilization temperature, the opening degree of the steam inlet valve 41 is increased, the opening degrees of the air inlet valve 42 and the air exhaust and mixing valve 7 are reduced, the proportion of high-temperature steam in the steam mixing box 6 is increased, and the sterilization box 1 realizes temperature rise and pressure rise after the mixed steam in the steam mixing box 6 is filled into the sterilization box 1; when the pressure of the inner chamber is higher than the preset pressure and the temperature of the inner chamber is higher than the sterilization temperature, the opening degree of the steam inlet valve 41 is reduced, the opening degrees of the air inlet valve 42 and the air exhaust mixing valve 7 are increased, the proportion of high-temperature steam in the steam mixing box 6 is reduced, and the sterilization box 1 realizes temperature reduction and pressure reduction after the mixed steam in the steam mixing box 6 is filled into the sterilization box 1. When the pressure of the inner chamber is equal to the preset pressure and the temperature of the inner chamber is equal to the sterilization temperature, the opening degrees of the steam inlet valve 41 and the air inlet valve 42 of the exhaust and mixing valve 7 are kept unchanged.
The invention also comprises a transition valve 8 arranged between the steam mixing box 6 and the sterilization box 1, when the transition valve 8 is opened, the steam mixing box 6 fills the mixed steam into the sterilization box 1; when the transition valve 8 is closed, the steam mixing box 6 stops filling steam into the sterilizing box 1. When the sterilization box 1 enters a sterilization state, the temperature of the inner chamber of the sterilization box 1 is kept consistent with the sterilization temperature, but the pressure of the inner chamber of the sterilization box 1 is easily reduced due to steam leakage or condensation, at the moment, the opening of the transition valve 8 is adjusted according to the preset pressure, the mixing proportion of high-temperature steam and clean air filled into the sterilization box 1 by the steam mixing box 6 is adjusted to adjust the mixing proportion of the high-temperature steam and the clean air in the sterilization box 1 until the pressure of the inner chamber is consistent with the preset pressure, the sterilization of the pre-filling needle 01 by the sterilization box 1 under the condition of constant temperature and constant pressure is effectively ensured, the deformation of the pre-filling needle 01 is avoided, and the safety and the reliability are.
Specifically, under the condition that the internal chamber temperature is consistent with the sterilization temperature, when the internal chamber pressure is lower than the preset pressure, the opening degree of the transition valve 8 is increased, high-temperature steam and clean air are charged into the sterilization box 1, the internal chamber pressure of the sterilization box 1 is increased, the internal chamber pressure is kept consistent with the preset pressure for a long time, and the sterilization quality is ensured.
In order to realize automation, the invention also comprises a sterilization pressure detection piece, a sterilization temperature detection piece and a controller, wherein the sterilization pressure detection piece is arranged in the sterilization box 1 and is used for detecting the pressure of the sterilization box 1 so as to obtain the pressure of the inner chamber. The sterilization pressure detection member may be a pressure sensor. The sterilization temperature detection piece is arranged in the sterilization box 1 and used for detecting the temperature of the sterilization box 1 so as to acquire the temperature of the inner chamber, and the sterilization temperature detection piece can be a temperature sensor.
The controller is respectively connected with the transition valve 8, the steam exhaust valve 5, the sterilization pressure detection part and the sterilization temperature detection part, and the transition valve 8 and the steam exhaust valve 5 can be electromagnetic valves.
When the inner chamber pressure is inconsistent with the preset pressure and the inner chamber temperature is inconsistent with the sterilization temperature, the sterilization pressure detection part and the sterilization temperature detection part simultaneously send signals to the controller, the controller adjusts the opening degrees of the transition valve 8 and the steam mixing valve 5 as required, the mixing proportion of high-temperature steam and clean air in the sterilization box 1 is directly changed, the inner chamber pressure is consistent with the preset pressure and the inner chamber temperature is consistent with the sterilization temperature, and therefore the inner chamber pressure and the inner chamber temperature of the sterilization box 1 are automatically adjusted.
In order to prevent the pressure in the steam mixing box 6 from being overhigh, the invention also comprises a steam mixing pressure detection piece 9 connected with the controller, and the steam mixing pressure detection piece 9 is arranged in the steam mixing box 6 and used for detecting the pressure of the steam mixing box 6 so as to obtain the steam mixing pressure. The mixture pressure detecting member 9 may be a pressure sensor. The exhaust steam mixing valve 7, the steam inlet pipeline 21, the air inlet pipeline 22 and the steam mixing pressure detection piece 9 are all connected with the controller.
When the mixed steam pressure is inconsistent with the designated pressure, the mixed steam pressure detection part 9 sends a signal to the controller, the controller adjusts the opening degrees of the exhaust mixed steam valve 7, the steam inlet pipeline 21 and the air inlet pipeline 22, and changes the mixing proportion of high-temperature steam and clean air in the mixed steam box 6, so that the mixed steam pressure of the mixed steam box 6 is adjusted until the mixed steam pressure is consistent with the designated pressure, the phenomenon that the steam pressure in the mixed steam box 6 is too high and the pressure loss of the mixed steam box 6 caused by leakage is compensated, and the safety is improved. The specified pressure here refers to the maximum pressure that the steam mixing box 6 can withstand.
In order to prevent the temperature in the steam mixing box 6 from being too high, the invention also comprises a steam mixing temperature detection piece 10 connected with the controller, and the steam mixing temperature detection piece 10 is arranged in the steam mixing box 6 and used for detecting the temperature of the steam mixing box 6 so as to obtain the steam mixing temperature. The mixed steam temperature detecting member 10 may be a temperature sensor. The mixed steam temperature detecting element 10 is connected with the controller.
When the mixed steam temperature is inconsistent with the specified temperature, the mixed steam temperature detection piece 10 sends a signal to the controller, the controller simultaneously adjusts the opening degrees of the exhaust mixed steam valve 7, the steam inlet pipeline 21 and the air inlet pipeline 22, and changes the mixing proportion of high-temperature steam and clean air in the mixed steam box 6, so that the mixed steam temperature of the mixed steam box 6 is automatically adjusted until the mixed steam temperature is consistent with the specified temperature, the overhigh steam temperature in the mixed steam box 6 is avoided, and the safety is further improved. The specified temperature here refers to the maximum temperature that the steam mixing box 6 can withstand.
The invention also comprises a sterilization humidity detection piece arranged in the sterilization box 1, the sterilization humidity detection piece is used for detecting the humidity of the sterilization box 1, and the sterilization humidity detection piece can be a humidity sensor and is connected with the controller. When the humidity in the sterilization box 1 is greater than the preset sterilization humidity, the sterilization humidity detection part sends a signal to the controller, the controller controls the steam exhaust valve 5 to be automatically opened, and the sterilization box 1 discharges condensed water to avoid the influence of the condensed water on the sterilization quality. Wherein the preset sterilization humidity refers to the maximum humidity of the sterilization box 1.
Of course, the invention also comprises a steam mixing humidity detection piece arranged in the steam mixing box 6, wherein the steam mixing humidity detection piece is used for detecting the humidity of the steam mixing box 6, and the steam humidity detection piece can be a humidity sensor and is connected with the controller. When the humidity of the steam mixing box 6 is greater than the preset steam mixing humidity, the steam mixing humidity detection part sends a signal to the controller, the controller controls the steam discharging and mixing valve 7 to be automatically opened, the steam mixing box 6 discharges condensed water, and the phenomenon that the condensed water of the steam mixing box 6 is too large is avoided. The preset steam mixing humidity refers to the maximum humidity of the steam mixing box 6.
Of course, a timer connected with the controller can be additionally arranged, and the controller periodically opens the steam exhaust valve 5 and the steam exhaust and mixing valve 7 according to signals fed back by the timer to periodically exhaust condensed water.
The pre-filling needle sterilization production method provided by the invention is based on the pre-filling needle sterilization production line and comprises the following steps:
judging whether the pressure of the inner chamber of the sterilization box 1 is consistent with the preset pressure of the pre-filling needle 01 or not, if so, keeping the opening degree of the steam inlet valve unchanged; if not, the opening of the steam inlet valve is adjusted according to the preset pressure so as to adjust the pressure of the inner chamber of the sterilization box 1 by changing the mixing proportion of the high-temperature steam and the clean air in the sterilization box 1 until the pressure of the inner chamber is consistent with the preset pressure.
When the inner chamber pressure of the sterilization box is inconsistent with the preset pressure and the inner chamber temperature is inconsistent with the sterilization temperature, the opening degree of a steam inlet valve 41 arranged on a steam inlet pipeline 21 at the inlet of the steam mixing box 6 and the opening degree of an air inlet valve 42 arranged on an air inlet pipeline 22 are adjusted, the mixing proportion of high-temperature steam and clean air in the steam mixing box 6 is adjusted, after the steam mixing box 6 fills steam into the sterilization box 1, the mixing proportion of the high-temperature steam and the clean air in the sterilization box 1 is adjusted, and the inner chamber pressure and the inner chamber temperature of the sterilization box 1 are adjusted until the inner chamber pressure is consistent with the preset pressure and the inner chamber temperature is consistent with the sterilization temperature.
The pre-filling needle sterilization production line and the production method provided by the invention are described in detail, the principle and the implementation mode of the invention are explained by applying specific examples, and the description of the examples is only used for helping to understand the method and the core idea of the invention; meanwhile, for a person skilled in the art, according to the idea of the present invention, there may be variations in the specific embodiments and the application scope, and in summary, the content of the present specification should not be construed as a limitation to the present invention.
Claims (9)
1. A pre-filled needle sterilization production line is characterized by comprising:
import and export sterilization case (1) that corresponds respectively and be equipped with admission pipeline and exhaust pipe way (3), the admission pipeline is equipped with the admission valve, exhaust pipe way (3) are equipped with exhaust valve (5), the admission pipeline be used for to sterilization case (1) fills high-temperature steam and clean air, the admission valve with exhaust valve (5) are used for adjusting self aperture through changing according to the pressure of predetermineeing of pre-filling needle (01) correspondingly in sterilization case (1) high-temperature steam and clean air's mixing proportion adjust the interior room pressure of sterilization case (1) until interior room pressure is unanimous with predetermineeing pressure.
2. The pre-filling needle sterilization production line according to claim 1, further comprising a steam mixing box (6) connected between the sterilization box (1) and the steam inlet pipeline, wherein the steam inlet pipeline comprises a steam inlet pipeline (21) and an air inlet pipeline (22) respectively arranged at an inlet of the steam mixing box (6), the steam inlet valve comprises a steam inlet valve (41) arranged at the steam inlet pipeline (21) and an air inlet valve (42) arranged at the air inlet pipeline (22), an outlet of the steam mixing box (6) is provided with an exhaust and mixing valve (7), and the exhaust and mixing valve (7), the steam inlet valve (41) and the air inlet valve (42) correspondingly adjust their opening degrees according to the preset pressure and sterilization temperature so as to adjust the pressure and the inner chamber temperature of the sterilization box (1) by adjusting the mixing ratio of the high-temperature steam and the clean air in the steam mixing box (6) until the pressure and the inner chamber pressure are consistent with the preset pressure and the inner chamber temperature are adjusted The temperature of the inner chamber is consistent with the sterilization temperature.
3. The pre-filling needle sterilization production line according to claim 2, further comprising a transition valve (8) arranged between the steam mixing box (6) and the sterilization box (1), wherein when the inner chamber temperature is consistent with the sterilization temperature, the transition valve (8) adjusts the opening degree thereof according to the preset pressure so as to adjust the mixing ratio of the high-temperature steam and the clean air in the sterilization box (1) by adjusting the mixing ratio of the high-temperature steam and the clean air filled into the sterilization box (1) by the steam mixing box (6) until the inner chamber pressure is consistent with the preset pressure.
4. The pre-fill needle sterilization line of claim 3, further comprising:
the sterilization pressure detection piece is arranged in the sterilization box (1) and is used for detecting the pressure of the sterilization box (1) so as to obtain the pressure of the inner chamber;
the sterilization temperature detection piece is arranged in the sterilization box (1) and is used for detecting the temperature of the sterilization box (1) so as to obtain the temperature of the inner chamber;
the controller is respectively connected with the transition valve (8), the exhaust valve (5), the sterilization pressure detection piece and the sterilization temperature detection piece;
the controller is used for simultaneously adjusting the opening degrees of the transition valve (8) and the exhaust valve (5) when the pressure of the inner chamber is inconsistent with the preset pressure and the temperature of the inner chamber is inconsistent with the sterilization temperature according to signals simultaneously sent by the sterilization pressure detection piece and the sterilization temperature detection piece so as to proportionally charge high-temperature steam and clean air into the sterilization box (1) until the pressure of the inner chamber is consistent with the preset pressure and the temperature of the inner chamber is consistent with the sterilization temperature.
5. The pre-fill needle sterilization line of claim 4, further comprising:
a mixed steam pressure detecting part (9) which is arranged on the mixed steam box (6) and is used for detecting the pressure of the mixed steam box (6) to obtain mixed steam pressure; the exhaust steam mixing valve (7), the steam inlet pipeline (21), the air inlet pipeline (22) and the steam mixing pressure detection part (9) are all connected with the controller, and the controller is used for adjusting the opening degrees of the exhaust steam mixing valve (7), the steam inlet pipeline (21) and the air inlet pipeline (22) according to signals sent by the steam mixing pressure detection part (9) when the steam mixing pressure is inconsistent with the specified pressure so as to adjust the steam mixing pressure until the steam mixing pressure is consistent with the specified pressure.
6. The pre-fill needle sterilization line of claim 5, further comprising:
a mixed steam temperature detecting element (10) which is arranged in the mixed steam box (6) and is used for detecting the temperature of the mixed steam box (6) so as to obtain the mixed steam temperature; the mixed steam temperature detection piece (10) is connected with the controller, and the controller is used for adjusting the opening degrees of the exhaust mixed steam valve (7), the steam inlet pipeline (21) and the air inlet pipeline (22) according to signals sent by the mixed steam temperature detection piece (10) when the mixed steam temperature is inconsistent with the specified temperature so as to adjust the mixed steam temperature until the mixed steam temperature is consistent with the specified temperature.
7. The pre-fill needle sterilization line of claim 4, further comprising:
locate in sterilization case (1) and be used for detecting sterilization humidity detection piece of sterilization case (1) humidity, sterilization humidity detection piece with the controller links to each other, the controller is used for according to the signal that sterilization humidity detection piece sent is in sterilization case (1) humidity is greater than preset sterilization humidity control steam exhaust valve (5) are opened in order to discharge the comdenstion water.
8. A pre-filling needle sterilization line according to any of the claims 1 to 7, further comprising a transfer trolley (11) provided inside the sterilization chamber (1), the transfer trolley (11) being provided with a tray (12) for supporting pre-filling needles (01).
9. A pre-filled needle sterilization production method based on the pre-filled needle sterilization production line of any one of claims 1 to 8, characterized by comprising the steps of:
judging whether the pressure of the inner chamber of the sterilization box is consistent with the preset pressure of the pre-filling needle or not, if so, keeping the opening degree of the steam inlet valve unchanged; if not, adjusting the opening of the steam inlet valve according to the preset pressure so as to adjust the pressure of the inner chamber of the sterilization box by changing the mixing proportion of high-temperature steam and clean air in the sterilization box until the pressure of the inner chamber is consistent with the preset pressure.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011079584.8A CN112168985A (en) | 2020-10-10 | 2020-10-10 | Pre-filling needle sterilization production line and production method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011079584.8A CN112168985A (en) | 2020-10-10 | 2020-10-10 | Pre-filling needle sterilization production line and production method |
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