CN110433314A - The accuracy control method and device of shape after the sterilizing of transfusion product - Google Patents
The accuracy control method and device of shape after the sterilizing of transfusion product Download PDFInfo
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- CN110433314A CN110433314A CN201910635615.4A CN201910635615A CN110433314A CN 110433314 A CN110433314 A CN 110433314A CN 201910635615 A CN201910635615 A CN 201910635615A CN 110433314 A CN110433314 A CN 110433314A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/24—Apparatus using programmed or automatic operation
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B55/00—Preserving, protecting or purifying packages or package contents in association with packaging
- B65B55/02—Sterilising, e.g. of complete packages
- B65B55/12—Sterilising contents prior to, or during, packaging
- B65B55/14—Sterilising contents prior to, or during, packaging by heat
-
- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D23/00—Control of temperature
- G05D23/19—Control of temperature characterised by the use of electric means
- G05D23/20—Control of temperature characterised by the use of electric means with sensing elements having variation of electric or magnetic properties with change of temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/14—Means for controlling sterilisation processes, data processing, presentation and storage means, e.g. sensors, controllers, programs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/20—Targets to be treated
- A61L2202/21—Pharmaceuticals, e.g. medicaments, artificial body parts
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Automation & Control Theory (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Mechanical Engineering (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The present invention relates to the accuracy control methods and device of shape after a kind of sterilizing of transfusion product, belong to technical field of medical equipment.The following steps are included: the temperature and pressure subsection setup of (1) to sterilizing warming-up section and the temperature descending section that sterilizes；(2) corresponding each segmentation, sets origin temp TJustWith outlet temperature TEventually, set starting point pressure PJustWith terminal pressure PEventually, set temperature rate of change △ T, control temperature change, the required pressure P in the segmentationXWith real-time temperature TXRelationship is as follows:Detect actual pressure P in sterilizer cavityIt is real, using the method for control pressure, PIt is realClose to PX.The present invention can accurately control its rate temperature change, accurately adjust pressure by sterilizing warming-up section and temperature descending section segmentation, it is ensured that product internal pressure external pressure keeps balance, keeps the good external form of product.
Description
Technical field
The present invention relates to the accuracy control methods and device of shape after a kind of sterilizing of transfusion product, belong to Medical Devices skill
Art field.
Background technique
At present there are type of thermosensitive sense similar drug in injection similar drug, this similar drug is different from the physiology salt of heat sensitivity difference
Water, long-time, which is under hot environment, be easy to cause drug effect to reduce, and directly affects the medical value of drug.This similar drug is to liter
Temperature fall time has very strict requirement, so can only be met the requirements by controlling the rate of heating and cooling.With " pharmaceutical production
Quality control procedure (2010 revise) " annex " computerized system " and " confirmation and verifying " publication and implementation, it is national right
The supervision of pharmacy corporation is more and more tighter, and pharmacy corporation itself also keeps good after the control to product temperature rate and product sterilize
Good external form requires higher and higher.
Along with the research and development of pharmacy corporation new drug, new sterilization process requirement is constantly proposed, especially to sterilizer
Temperature rate and time, more stringent requirements are proposed, first before the product sterilizing produced additionally, due to different pharmacy corporations
Beginning situation is different, such as the content of air, the thickness of product and uniformity, production in the material of product, the filling temperature of medicine company, product
The different factors such as disposing way of product when external pressure situation, the sterilizing when shapes of product itself, sterilizing, external form is difficult after product sterilizing
It keeps, because external form destroys scrap of the product, increases the rejection rate of product.
Summary of the invention
The object of the present invention is to provide the accuracy control methods and device of shape after a kind of sterilizing of transfusion product, by going out
Bacterium warming-up section and temperature descending section segmentation, can accurately control its rate temperature change, accurately adjust pressure, it is ensured that product internal pressure external pressure
Balance is kept, the good external form of product is kept.
The accuracy control method of shape after transfusion product sterilizing of the present invention, comprising the following steps:
(1) to the temperature and pressure subsection setup of sterilizing warming-up section and the temperature descending section that sterilizes；
(2) corresponding each segmentation, sets origin temp TJustWith outlet temperature TEventually, set starting point pressure PJustAnd terminal pressure
PEventually, set temperature rate of change △ T, control temperature change, the required pressure P in the segmentationXWith real-time temperature TXIt closes
It is as follows:
(3) actual pressure P in sterilizer cavity is detectedIt is real, using the method for control pressure, PIt is realClose to PX。
The method of the control pressure is PIt is real< PX-A opens cavity into compressed air valve, compression is supplemented into cavity
Air；Work as PIt is real>PX, cavity is closed into compressed air valve, stops supplementing compressed air into cavity；Work as PIt is real>PX+A opens cavity
Row pressure contracting air valve discharges compressed air in cavity；Work as PIt is real<PX, cavity row pressure contracting air valve is closed, it is empty to stop compression in release cavity
Gas.It loops back and forth like this, controls actual pressure PIt is realStablize in the proper range, keeps product shape indeformable.
The warming-up section, works as PIt is real>PEventually+ A or PIt is real<PJust- A, warning reminding.
The temperature descending section, works as PIt is real>PJust+ A or PIt is real<PEventually- A, warning reminding.
Described, 3 < A < 5.
The method of the control temperature change is as follows, and in segmentation, temperature sensor detects the temperature in the unit time
Rate of change T is greater than the rate temperature change △ T of setting, closes cavity into steam valve；Deng until opened in next unit time
Open steam valve 7.
It is further preferred that in the continuous N sections of unit time；Temperature sensor detects the temperature in the unit time
Rate of change T is greater than the rate temperature change △ T of setting or temperature sensor detects the speed of the temperature change in the unit time
Rate T is less than the rate temperature change △ T of setting；Warning reminding.2≤N≤25.Sterilising temp situation of change as needed, if
Determine the numerical value of N, that is, the accuracy of regulating and controlling temperature rate of change has been determined.
The wise temperature in the stage that is rapidly heated is poor, and the wise temperature greater than the slow temperature rise period is poor；It is quickly cooled down
The wise temperature in stage is poor, and the wise temperature greater than the Slow cooling stage is poor.
The precise control device of shape after the transfusion product sterilizing that method of the present invention uses, including sterilizer chamber
Body, sterilizer cavity are respectively communicated with cavity row pressure contracting air valve, cavity into compression air valve and cavity into steam valve, sterilizer cavity
Interior to be equipped with temperature sensor, sterilizer cavity connects pressure sensor, and cavity row pressure contracting air valve, cavity are into compressing air valve and cavity
Pass through connection PLC system into steam valve, temperature sensor and pressure sensor, PLC system connects sound-light alarm dress
It sets, PLC system connects HMI system.
Currently, being idealized as one one using set temperature rate of change, and according to the variation of pressure following temperature when sterilizing
The variation relation of secondary function y=kx+b, wherein k is pressure coefficient, and x is the temperature in bottle, and b is a constant.It goes out in product
Before bacterium, what a pressure coefficient k and constant b are set in man-machine interface, product is in sterilization process, with temperature x in product
It increases, to pressure p=kx+b that product supplements, to reach the balance of product external and internal pressure stress.
By studying test discovery repeatedly, the control for the temperature rate that the prior art uses, is in entire heating rank
A rate can only be arranged in section or cooling stage, if rate values setting is excessive, will lead into sterilizing holding stage temperature
Height is broken through on degree, influences the uniformity of sterilizing holding stage temperature, if rate setting is too small, will lead to heating early period or cold
But the overlong time in later period is not able to satisfy time requirement of the pharmacy corporation to the sterilizer production cycle.The pressure that the prior art uses
The variation of pressure following temperature is idealized as the variation relation of a linear function y=kx+b, but actually gone out by power control mode
During bacterium, for product temperature during rise and fall, pressure variation with temperature is not fully according to a letter in product
The mode of number y=kx+b changes, and approximate can only regard the variation of linear function y=kx+b as in some small temperature range
Relationship, temperature of the product within entire temperature rise period, cooling stage, product is during raising and lowering, by primary
The variation relation of function y=kx+b supplements external pressure to product, stress condition or difference inside and outside product, if interiors of products
Pressure is higher than external pressure, and the swell increment of product is excessive, the coefficient of elasticity range beyond product material itself, leads to cooling rank
Duan Buneng restores, and product occurs severely deformed；, whereas if the pressure of interiors of products will lead to product lower than external pressure
There is the part of air to be recessed.
Moreover, different products, characteristic is different, and the rate of required heating and cooling is also different, for pressure
Susceptibility it is also different.Product is in sterilization process, during entire heating, cooling, pressure follow temperature in product
Variation is without regularity.Product is initial in heating, it is desirable that is rapidly heated, close to after the sterilising temp of setting, it is desirable that slowly heating.
Product is cooling initial, it is desirable that Slow cooling, after the cooling period phase, it is desirable that be quickly cooled down.Product is in sterilization process, inside and outside appearance
Pressure imbalance when, operator can not have found, until touring discovery, often product has been scrapped, and cause to waste.
Compared with prior art, the beneficial effects of the present invention are:
1, the present invention is divided into segment by will heat up section and temperature descending section, to each independent segmentation, becomes respectively to temperature
Change and pressure change is using control, controls more accurate, rate temperature change that can be different to different Discrete controls, it can either
Meet product for the requirement that heats up and cool down, and be able to maintain in product heating and temperature-fall period, required for accurate measuring and calculating
Pressure, and pressure change is controlled close to required pressure into the switch of compressed air valve and cavity row pressure contracting air valve by cavity
Power keeps balance with product external pressure to realize in product, product shape is kept not cause to become because of temperature, pressure change
Shape reduces product because external form deformation leads to product rejection rate；The variation slope of different independent segmented interior pressure follow temperature
Difference, the mode for being equivalent to multiple linear function superpositions carry out control pressure, can preferably control the pressure balance inside and outside bottle.
Product can preferably be controlled in different temperature range corresponding pressure values, it is ensured that bottle-type reaches optimum efficiency after product sterilizing.
2, according to drug characteristic, the present invention can control heating rate and rate of temperature fall in different temperature zones, improve
The uniformity of temperature improves the temperature uniformity of sterilizer sterilizing holding stage, reduces cooling stage product and scrap
Probability.
3, the present invention solves the problems, such as that product occurs serious modification after high temperature and high pressure environment sterilizes and even scraps, and subtracts
The waste for having lacked pharmacy corporation raw material reduces the production cost of enterprise.
4, when temperature or pressure do not change according to temperature, pressure in the stage divided in advance, i.e., temperature change it is abnormal or
It when pressure change exception, can be reminded in a manner of sound-light alarm in time, staff is reminded to adjust in time, it is useless to reduce product
Product rate.
Detailed description of the invention
Fig. 1 is the embodiment of the precise control device of shape after the transfusion product that method of the present invention uses sterilizes
1 structural schematic diagram,
Fig. 2 is the measuring and calculating schematic diagram of pressure needed in the segmentation and segmentation of temperature and pressure of the present invention.
In figure: 1, sterilizer cavity 2, temperature sensor 3, cavity row pressure contracting air valve 4, acoustic-optic alarm 5, HMI
System 6, PLC system 7, pressure sensor 8, cavity are into compression air valve 9, cavity into steam valve.
Specific embodiment
Following will be combined with the drawings in the embodiments of the present invention, and technical solution in the embodiment of the present invention is made further clear
Chu is fully described by:
Embodiment 1
As shown in Fig. 2, after transfusion product of the present invention sterilizing shape accuracy control method, including following step
It is rapid:
(1) according to the characteristic of product subject to sterilization, the warming-up section that sterilizes to it and sterilizing temperature descending section are divided into multiple segments, to go out
Bacterium warming-up section is divided into 12 segments, and sterilizing temperature descending section is divided into for 12 segments；
(2) in HMI system 5, the corresponding origin temp T for inputting each segmentationJustWith outlet temperature TEventually, set starting point pressure
PJustWith terminal pressure PEventually, the heating rate △ T in the temperature section is then inputted, with the continuous rising of Tx temperature, is needed to going out
Bacterium product supplement pressure Px constantly become larger, according to the relationship of linear function it follows that
Px is the pressure supplemented required for calculating sterilizer cavity 1 in segmentation.
Below with 121.0 DEG C of 500ml plastic bottle sterilization temperature, the technique of sterilization time 15min lifts column explanation to this programme
It is as follows: origin temp TJust, outlet temperature TEventually, starting point pressure PJustWith terminal pressure PEventually, the setting of rate temperature change:
01 section: 40-60 DEG C of heating；12-20KPA；7.0℃/min；
02 section: 60-80 DEG C of heating, 20-40KPA；7.0℃/min；
03 section: 60-80 DEG C of heating, 40-89KPA；7.0℃/min；
04 section: 80-100 DEG C of heating, 89-168KPA；7.0℃/min；
05 section: 100-105 DEG C of heating, 168-197KPA；5.0℃/min；
06 section: 105-110 DEG C of heating, 197-216KPA；5.0℃/min；
07 section: 110-113 DEG C of heating, 216-229KPA；5.0℃/min；
08 section: 113-115 DEG C of heating, 229-243KPA；3.0℃/min；
09 section: 115-117 DEG C of heating, 243-257KPA；3.0℃/min；
10 sections: 117-119 DEG C of heating, 257-271KPA；2.0℃/min；
11 sections: 119-121 DEG C of heating, 271-275KPA；1.5℃/min；
12 sections: 121-122 DEG C of heating, 275-278KPA；0.5℃/min；
Temperature hold section: 121 DEG C, 275-278KPA；Soaking time 15min；
01 section: 122-121 DEG C of cooling；283-280KPA；0.7℃/min；
02 section: 121-119 DEG C of cooling, 280-276KPA；1.2℃/min；
03 section: 119-117 DEG C of cooling, 276-262KPA；2.2℃/min；
04 section: 117-115 DEG C of cooling, 262-248KPA；3.0℃/min；
05 section: 115-113 DEG C of cooling, 248-234KPA；3.0℃/min；
06 section: 113-110 DEG C of cooling, 234-221KPA；3.0℃/min；
07 section: 110-105 DEG C of cooling, 221-202KPA；5.0℃/min；
08 section: 105-100 DEG C of cooling, 202-173KPA；5.0℃/min；
09 section: 100-80 DEG C of cooling, 173-84KPA；8.0℃/min；
10 sections: 80-60 DEG C of cooling, 84-45KPA；8.0℃/min；
11 sections: 60-40 DEG C of cooling, 45-20KPA；10.0℃/min；
12 sections: 40-20 DEG C of cooling, 20-12KPA；10.0℃/min；
Be rapidly heated the stage wise temperature it is poor, the wise temperature greater than the slow temperature rise period is poor；The rapid cooling stage
Wise temperature is poor, and the wise temperature greater than the Slow cooling stage is poor.
In the present embodiment, 0-113 DEG C belongs to the stage of being rapidly heated, and 113-121 DEG C belongs to the slow temperature rise period；121-110
Belong to the Slow cooling stage, 110-0 DEG C belongs to the rapid cooling stage.There is sterilizing holding stage in centre, and temperature is maintained at 121-122
DEG C, soaking time 15min.
By taking 08 section of heating as an example, heating rate is 3.0 DEG C/min；
With one minute for the unit time, if temperature sensor 2 detects that the heating rate T in the unit time is greater than setting
Heating rate △ T, PLC system 4 control cavity into steam valve 7 close, wait until in next unit time again control steam
Steam valve door 7 is opened.
When temperature is raised to 114 DEG C, the pressure that requires supplementation with are as follows: Px=229+ (243-229)/(115-113) * (114-
113)=236KPA；
(3) actual pressure in sterilizer cavity 1 is then detected by pressure sensor 3,
When the actually detected pressure P arrived is less than 232KPA, PLC system 4 controls cavity and opens into compressed air valve 8, gives
Cavity 1 supplements compressed air, after the pressure P detected is greater than 236KPA, closes into compressed air valve 8；If when practical
When the pressure P detected is greater than 240KPA, PLC system 4 controls the opening of cavity row pressure contracting air valve 9 and is exhausted, when what is detected
After pressure P is less than 236KPA, cavity row pressure contracting air valve 9 is closed；It loops back and forth like this, so that PIt is realClose to PX.It is able to maintain product
Internal and external pressure balance keeps the good external form of product.
Period, if the actually detected pressure P arrived is greater than the 247KPA or actually detected pressure P arrived and is less than 225KPA,
Then acoustic-optic alarm 4 issues sound-light alarm, prompts staff to check equipment, avoids scrap of the product.In continuous 2min, temperature
Sensor detects that the rate temperature change T in the unit time is greater than 3.0 DEG C of rate temperature change of setting；Then sound-light alarm fills
4 sending sound-light alarms are set, prompts staff to check equipment, avoids scrap of the product.
In continuous 2min, temperature sensor detects that the rate temperature change T in the unit time is less than the temperature change of setting
Change 3.0 DEG C of rate；Then acoustic-optic alarm 4 issues sound-light alarm, prompts staff to check equipment, avoids scrap of the product.
Other temperature section control methods are consistent.It will not go into details.
Equally with 121.0 DEG C of 500ml plastic bottle sterilization temperature, the parameter of the technique of sterilization time 15min, the prior art is set
It sets as follows:
A:85 DEG C of pressure formula；Pressure formula B:45KPA；Pressure coefficient 6.4.
The prior art is Px=(T-85) × K+45, Wu Fagen in the pressure that entire warming-up section or cooling section require supplementation with
It is supplemented according to the pressure of plastic bottle actual demand.
It is sterilized the modification situation of front and back bottle-type by comparison, using the prior art, 500ml plastic bottle is at 121 DEG C, 15min
After sterilizing, the shrinking percentage of plastic bottle is 18% or so；And this programme is used, and it is equally 500ml plastic bottle at 121 DEG C, 15min sterilizing
Afterwards, the shrinking percentage of plastic bottle is 7% or so.
As shown in Figure 1, after transfusion product of the present invention sterilizing shape precise control device, including sterilizer chamber
Body 1, sterilizer cavity 1 are respectively communicated with cavity row pressure contracting air valve 3, cavity into compression air valve 8 and cavity into steam valve 9, sterilize
It is equipped with temperature sensor 2 in device cavity 1, sterilizer cavity 1 connects pressure sensor 7, and cavity row pressure contracting air valve 8, cavity are into pressure
Contracting air valve 8 and cavity pass through connection PLC system 6, PLC system into steam valve 9, temperature sensor 2 and pressure sensor 7
6 connection acoustic-optic alarm 4 of system, PLC system 6 connect HMI system 5.
PLC system is conventional programming Control system；HMI system is conventional man-machine interactive system；Acoustic-optic alarm 4 is
Conventional acousto-optic warning device.2 model XH-PT1-222110-150 of temperature sensor, brand: JUMO；Pressure sensor model: A-
10 0-4bar, board: WIKA.
In pressure control, adjusting difference A can be 3KPA, 3.5KPA, 4.5KPA or 5KPA.
Embodiment 2
On the basis of embodiment 1, in the continuous N sections of unit time；Temperature sensor detects the temperature in the unit time
Degree rate of change T is greater than the rate temperature change △ T of setting or temperature sensor detects the temperature change in the unit time
Rate T is less than the rate temperature change △ T of setting；Warning reminding.2≤N≤25.Sterilising temp situation of change as needed,
The numerical value of N is set, that is, the accuracy of regulating and controlling temperature rate of change has been determined.N can for 2,3,4,5,6,10,15,20 or
25.Preferably, 5,10 or 20 N.
Pressure sensor: refer to diaphragm device (stainless steel diaphragm, silicone diaphragm etc.) for medium, with pressure element to gas
The pressure of body and liquid measures, and is converted into the equipment device of electric signal output.
Temperature sensor: refer to the sensor that can be experienced temperature change and be converted into usable output signal.
Claims (8)
1. the accuracy control method of shape after a kind of transfusion product sterilizing, which comprises the following steps:
(1) to the temperature and pressure subsection setup of sterilizing warming-up section and the temperature descending section that sterilizes；
(2) corresponding each segmentation, sets origin temp TJustWith outlet temperature TEventually, set starting point pressure PJustWith terminal pressure PEventuallyIf
Determine rate temperature change △ T, controls temperature change, the required pressure P in the segmentationXWith real-time temperature TXRelationship is such as
Under:
(3) actual pressure P in sterilizer cavity is detectedIt is real, using the method for control pressure, PIt is realClose to PX。
2. the accuracy control method of shape after transfusion product sterilizing according to claim 1, which is characterized in that described
The method for controlling pressure is P reality < PX-A, opens cavity into compressed air valve, compressed air is supplemented into cavity；Work as PIt is real>PX,
Cavity is closed into compressed air valve, stops supplementing compressed air into cavity；Work as PIt is real>PX+ A opens cavity row pressure contracting air valve, releases
Put compressed air in cavity；Work as PIt is real<PX, cavity row pressure contracting air valve is closed, compressed air in release cavity is stopped.
3. the accuracy control method of shape after transfusion product sterilizing according to claim 2, which is characterized in that heating
Section, works as PIt is real>PEventually+ A or PIt is real<PJust- A, warning reminding.
4. the accuracy control method of shape after transfusion product sterilizing according to claim 2, which is characterized in that cooling
Section, works as PIt is real>PJust+ A or PIt is real<PEventually- A, warning reminding.
5. according to the accuracy control method of shape after the described in any item transfusion product sterilizings of claim 2-4, feature exists
In 3 < A < 5.
6. the accuracy control method of shape after transfusion product sterilizing according to claim 1, which is characterized in that control temperature
The method for spending variation is as follows, and in segmentation, temperature sensor detects that the rate temperature change T in the unit time is greater than the temperature of setting
Rate of change △ T is spent, closes cavity into steam valve；Deng until in next unit time, steam valve 7 is opened.
7. the accuracy control method of shape after transfusion product sterilizing according to claim 1, which is characterized in that quickly rise
The wise temperature of thermophase is poor, and the wise temperature greater than the slow temperature rise period is poor；The wise temperature in rapid cooling stage is poor, is greater than
The wise temperature in Slow cooling stage is poor.
8. the precise control device of shape after a kind of transfusion product sterilizing used using method described in claim 1-7,
It is characterised in that it includes sterilizer cavity (1), sterilizer cavity (1) is respectively communicated with cavity row pressure contracting air valve (3), cavity into pressure
Contracting air valve (8) and cavity are into steam valve (9), and sterilizer cavity (1) is interior to be equipped with temperature sensor (2), and sterilizer cavity (1) is even
It connects pressure sensor (7), cavity row pressure contracting air valve (8), cavity are passed into compression air valve (8) and cavity into steam valve (9), temperature
By connection PLC system (6), PLC system (6) connects acoustic-optic alarm (4) for sensor (2) and pressure sensor (7),
PLC system (6) connects HMI system (5).
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| CN201910635615.4A CN110433314A (en) | 2019-07-15 | 2019-07-15 | The accuracy control method and device of shape after the sterilizing of transfusion product |
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| CN201910635615.4A CN110433314A (en) | 2019-07-15 | 2019-07-15 | The accuracy control method and device of shape after the sterilizing of transfusion product |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112596555A (en) * | 2020-12-11 | 2021-04-02 | 楚天科技股份有限公司 | Control method and system for temperature rise and pressure rise of air and steam mixed sterilization cabinet |
| CN115531564A (en) * | 2022-08-22 | 2022-12-30 | 青岛海尔生物医疗科技有限公司 | Method and device for sterilization temperature control, steam sterilizer and storage medium |
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| CN115531564A (en) * | 2022-08-22 | 2022-12-30 | 青岛海尔生物医疗科技有限公司 | Method and device for sterilization temperature control, steam sterilizer and storage medium |
| CN115531564B (en) * | 2022-08-22 | 2024-03-15 | 青岛海尔生物医疗科技有限公司 | Method and device for sterilization temperature control, steam sterilizer and storage medium |
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