CN112167630A - Gamma-aminobutyric acid oral-aid functional food formula and preparation method - Google Patents
Gamma-aminobutyric acid oral-aid functional food formula and preparation method Download PDFInfo
- Publication number
- CN112167630A CN112167630A CN202010601265.2A CN202010601265A CN112167630A CN 112167630 A CN112167630 A CN 112167630A CN 202010601265 A CN202010601265 A CN 202010601265A CN 112167630 A CN112167630 A CN 112167630A
- Authority
- CN
- China
- Prior art keywords
- gamma
- aminobutyric acid
- pyrrolidone
- stirring
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 title claims abstract description 198
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 title claims abstract description 99
- 229960003692 gamma aminobutyric acid Drugs 0.000 title claims abstract description 99
- 235000013376 functional food Nutrition 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 238000009472 formulation Methods 0.000 title claims description 7
- 238000003756 stirring Methods 0.000 claims abstract description 43
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 42
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 38
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims abstract description 38
- 238000010438 heat treatment Methods 0.000 claims abstract description 31
- 238000006243 chemical reaction Methods 0.000 claims abstract description 30
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 claims abstract description 29
- 239000003513 alkali Substances 0.000 claims abstract description 20
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 19
- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 claims abstract description 19
- BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 claims abstract description 19
- DAYLJWODMCOQEW-TURQNECASA-N NMN zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP(O)([O-])=O)O2)O)=C1 DAYLJWODMCOQEW-TURQNECASA-N 0.000 claims abstract description 19
- 229920002472 Starch Polymers 0.000 claims abstract description 19
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 19
- 229930006000 Sucrose Natural products 0.000 claims abstract description 19
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 19
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 19
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 19
- 239000008101 lactose Substances 0.000 claims abstract description 19
- 235000019359 magnesium stearate Nutrition 0.000 claims abstract description 19
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 claims abstract description 19
- 229960003987 melatonin Drugs 0.000 claims abstract description 19
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 19
- 239000002002 slurry Substances 0.000 claims abstract description 19
- 239000008107 starch Substances 0.000 claims abstract description 19
- 235000019698 starch Nutrition 0.000 claims abstract description 19
- 239000005720 sucrose Substances 0.000 claims abstract description 19
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 16
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 16
- 230000002378 acidificating effect Effects 0.000 claims abstract description 14
- 239000007788 liquid Substances 0.000 claims abstract description 13
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims abstract description 12
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 10
- 238000005341 cation exchange Methods 0.000 claims abstract description 8
- 239000011780 sodium chloride Substances 0.000 claims abstract description 8
- 239000007787 solid Substances 0.000 claims abstract description 8
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims abstract description 7
- 238000005086 pumping Methods 0.000 claims abstract description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 18
- 239000012530 fluid Substances 0.000 claims description 18
- 238000000926 separation method Methods 0.000 claims description 18
- 239000011734 sodium Substances 0.000 claims description 18
- 229910052708 sodium Inorganic materials 0.000 claims description 18
- 235000011121 sodium hydroxide Nutrition 0.000 claims description 13
- 239000013078 crystal Substances 0.000 claims description 12
- 238000001035 drying Methods 0.000 claims description 12
- 238000001914 filtration Methods 0.000 claims description 12
- 239000000843 powder Substances 0.000 claims description 12
- 238000001223 reverse osmosis Methods 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 7
- 239000011230 binding agent Substances 0.000 claims description 6
- 150000001768 cations Chemical class 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 6
- 238000007599 discharging Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 238000005342 ion exchange Methods 0.000 claims description 6
- 239000011159 matrix material Substances 0.000 claims description 6
- 229960003943 hypromellose Drugs 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims 5
- 238000000034 method Methods 0.000 claims 3
- 235000013305 food Nutrition 0.000 abstract description 5
- 239000002994 raw material Substances 0.000 abstract description 4
- 238000002425 crystallisation Methods 0.000 abstract description 2
- 230000008025 crystallization Effects 0.000 abstract description 2
- 238000006386 neutralization reaction Methods 0.000 abstract description 2
- 230000002829 reductive effect Effects 0.000 abstract description 2
- 238000007142 ring opening reaction Methods 0.000 abstract description 2
- 241000227653 Lycopersicon Species 0.000 description 2
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003925 brain function Effects 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Indole Compounds (AREA)
Abstract
The invention discloses a gamma-aminobutyric acid servo-assisted functional food formula and a preparation method thereof, wherein the formula mainly comprises the following components in parts by weight: pyrrolidone, alkali liquor, melatonin, NMN, hydroxypropyl methylcellulose, magnesium stearate, NAD, silicon dioxide, sucrose, lactose and starch slurry, wherein the preparation method comprises the following steps: pumping the pyrrolidone into a reaction kettle by a pump, dripping the liquid alkali pumped into the high-level kettle by the hydraulic pump into the reaction kettle with the pyrrolidone under the condition of stirring, heating to 55-65 ℃ by steam, and preserving heat for 1-2 hours. According to the invention, through ring opening of pyrrolidone and sodium hydroxide or potassium hydroxide, neutralization and acidic cation exchange are carried out by using a sodium chloride solution, the solution is prepared firstly, and then crystallization is introduced to prepare the solid gamma-aminobutyric acid, so that the conversion rate can reach more than 90%, the utilization rate of raw materials is improved, and the food preparation cost is reduced.
Description
Technical Field
The invention relates to the technical field of functional food preparation, in particular to a formula and a preparation method of gamma-aminobutyric acid oral-aid functional food.
Background
Gamma-aminobutyric acid is a nonprotein amino acid widely distributed in the biological world, is known to act as an inhibitory neurotransmitter in higher animals, and has been reported to have various physiological functions, including a hypotensive effect, a brain function improving effect, a mental tranquilization effect, and the like.
Through search, chinese patent publication No. CN1923059B discloses a method for producing a food and drink rich in γ -aminobutyric acid and a food and drink rich in γ -aminobutyric acid, which comprises fermenting a tomato-treated product having a filtrate color degree of 0.02 to 0.2 when a sugar degree is adjusted to 3% with lactic acid bacteria, and converting glutamic acid or a salt thereof in the tomato-treated product to γ -aminobutyric acid in an amount of 60% or more.
The above patent has disadvantages that the conversion rate of converting the raw material into gamma-aminobutyric acid is only sixty percent or more, slightly over half, and the conversion rate is low, which results in serious waste of raw materials and directly results in increase of the cost of food containing gamma-aminobutyric acid.
Disclosure of Invention
The invention aims to solve the problem that most people suffer from rheumatic arthralgia at present, and provides a formula and a preparation method of a gamma-aminobutyric acid oral-aid functional food.
In order to achieve the purpose, the invention adopts the following technical scheme:
the formula of the gamma-aminobutyric acid oral-aid functional food mainly comprises the following components in parts by weight: pyrrolidone: 5-7, alkali liquor: 2-4, melatonin: 4.5-8.5, NMN: 0.4-1.6, hydroxypropyl methylcellulose 2-6, magnesium stearate: 3-7, NAD: 0.4-1.6, silica: 0.4-1.6, sucrose: 0.2-0.8, lactose: 0.2-0.8, starch slurry: 0.7-1.3.
As a still further scheme of the invention: the pyrrolidone: 5.5-6.5, alkali liquor: 2.5-3.5, melatonin: 5-8, NMN: 0.6-1.2, hydroxypropyl methylcellulose 3-5, magnesium stearate: 5-6, NAD: 0.6-1.4, silica: 0.6-1.4, sucrose: 0.4-0.6, lactose: 0.4-0.6, starch slurry: 0.8-1.2.
As a still further scheme of the invention: the pyrrolidone: 5.8-6.2, alkali liquor: 2.8-3.2, melatonin: 6-7, NMN: 0.8-1, hydroxypropyl methylcellulose 3.5-5.5, magnesium stearate: 5.2-5.8, NAD: 0.8-1.2, silica: 0.8-1.2, sucrose: 0.45-0.55, lactose: 0.45-0.55, starch slurry: 0.9-1.1.
As a still further scheme of the invention: the pyrrolidone: 5. alkali liquor: 3. melatonin: 6.5, NMN: 0.9, hypromellose 4.5, magnesium stearate: 5.5, NAD: 1. Silicon dioxide: 1. sucrose: 0.5, lactose: 0.5, starch slurry: 1.
as a still further scheme of the invention: the alkali liquor is 20-25% sodium hydroxide solution or 20-25% potassium hydroxide solution.
A preparation method of a formula of a gamma-aminobutyric acid oral-aid functional food comprises the following steps:
s1: pumping the pyrrolidone into a reaction kettle by a pump, dripping the liquid caustic soda pumped into the high-level kettle by a hydraulic pump into the reaction kettle with the pyrrolidone under the condition of stirring, heating to 55-65 ℃ by steam, and preserving heat for 1-2 hours;
s2: cooling to 10 ℃ by using cold liquid, discharging, and filtering to obtain a gamma-aminobutyric acid sodium filtrate;
s3: entering a continuous fluid separation device for conversion, namely entering the gamma-aminobutyric acid sodium dialysate into a continuous fluid separation device for ion exchange by a continuous acidic cation exchange column to convert the gamma-aminobutyric acid sodium into a gamma-aminobutyric acid solution;
s4: concentrating by reverse osmosis, namely concentrating the gamma-aminobutyric acid solution from the continuous fluid separation device by a reverse osmosis system to obtain gamma-aminobutyric acid concentrated solution;
s5: introducing crystals, and adding gamma-aminobutyric acid seed crystals into the gamma-aminobutyric acid concentrated solution to obtain gamma-aminobutyric acid;
s6: filtering and drying the gamma-aminobutyric acid to obtain clean gamma-aminobutyric acid;
s7: adding gamma-aminobutyric acid, melatonin, NMN, NAD, sucrose and lactose into a reaction kettle, heating by using steam, and starting a stirrer for stirring;
s8: then adding hydroxypropyl methylcellulose, magnesium stearate and silicon dioxide, continuing stirring, gradually adding starch slurry while stirring, and continuously stirring to a viscous state;
s9: then heating and drying, continuously stirring until solid, and then crushing into powder with 80-100 meshes by using a crusher;
s10: the powder is then added with a binder and pressed into granules using a die.
In the S3, the acidic cation is exchanged by using a sodium chloride solution with the concentration of 20-25% as a matrix.
In the step S7, the heating temperature is 50 ℃, the heating time is 15-20 minutes, and the rotation speed of the stirrer is 800-100 r/min.
In the S8, the stirring speed is 300-500 r/min.
The invention has the beneficial effects that:
1. according to the invention, through ring opening of pyrrolidone and sodium hydroxide or potassium hydroxide, neutralization and acidic cation exchange are carried out by using a sodium chloride solution, the solution is prepared firstly, and then crystallization is introduced to prepare the solid gamma-aminobutyric acid, so that the conversion rate can reach more than 90%, the utilization rate of raw materials is improved, and the food preparation cost is reduced.
Detailed Description
The technical solution of the present patent will be described in further detail with reference to the following embodiments.
The following detailed description of embodiments of the patent is merely illustrative of the patent and is not to be construed as limiting the patent.
Example 1
The formula of the gamma-aminobutyric acid oral-aid functional food mainly comprises the following components in parts by weight: pyrrolidone: 5-7, alkali liquor: 2-4, melatonin: 4.5-8.5, NMN: 0.4-1.6, hydroxypropyl methylcellulose 2-6, magnesium stearate: 3-7, NAD: 0.4-1.6, silica: 0.4-1.6, sucrose: 0.2-0.8, lactose: 0.2-0.8, starch slurry: 0.7-1.3.
The alkali liquor is 20-25% sodium hydroxide solution or 20-25% potassium hydroxide solution.
A preparation method of a formula of a gamma-aminobutyric acid oral-aid functional food comprises the following steps:
s1: pumping the pyrrolidone into a reaction kettle by a pump, dripping the liquid caustic soda pumped into the high-level kettle by a hydraulic pump into the reaction kettle with the pyrrolidone under the condition of stirring, heating to 55-65 ℃ by steam, and preserving heat for 1-2 hours;
s2: cooling to 10 ℃ by using cold liquid, discharging, and filtering to obtain a gamma-aminobutyric acid sodium filtrate;
s3: entering a continuous fluid separation device for conversion, namely entering the gamma-aminobutyric acid sodium dialysate into a continuous fluid separation device for ion exchange by a continuous acidic cation exchange column to convert the gamma-aminobutyric acid sodium into a gamma-aminobutyric acid solution;
s4: concentrating by reverse osmosis, namely concentrating the gamma-aminobutyric acid solution from the continuous fluid separation device by a reverse osmosis system to obtain gamma-aminobutyric acid concentrated solution;
s5: introducing crystals, and adding gamma-aminobutyric acid seed crystals into the gamma-aminobutyric acid concentrated solution to obtain gamma-aminobutyric acid;
s6: filtering and drying the gamma-aminobutyric acid to obtain clean gamma-aminobutyric acid;
s7: adding gamma-aminobutyric acid, melatonin, NMN, NAD, sucrose and lactose into a reaction kettle, heating by using steam, and starting a stirrer for stirring;
s8: then adding hydroxypropyl methylcellulose, magnesium stearate and silicon dioxide, continuing stirring, gradually adding starch slurry while stirring, and continuously stirring to a viscous state;
s9: then heating and drying, continuously stirring until solid, and then crushing into powder with 80-100 meshes by using a crusher;
s10: the powder is then added with a binder and pressed into granules using a die.
In the S3, the acidic cation is exchanged by using a sodium chloride solution with the concentration of 20-25% as a matrix.
In the step S7, the heating temperature is 50 ℃, the heating time is 15-20 minutes, and the rotation speed of the stirrer is 800-100 r/min.
In the S8, the stirring speed is 300-500 r/min.
Example 2:
the formula of the gamma-aminobutyric acid oral-aid functional food mainly comprises the following components in parts by weight: pyrrolidone: 5.5-6.5, alkali liquor: 2.5-3.5, melatonin: 5-8, NMN: 0.6-1.2, hydroxypropyl methylcellulose 3-5, magnesium stearate: 5-6, NAD: 0.6-1.4, silica: 0.6-1.4, sucrose: 0.4-0.6, lactose: 0.4-0.6, starch slurry: 0.8-1.2.
The alkali liquor is 20-25% sodium hydroxide solution or 20-25% potassium hydroxide solution.
A preparation method of a formula of a gamma-aminobutyric acid oral-aid functional food comprises the following steps:
s1: pumping the pyrrolidone into a reaction kettle by a pump, dripping the liquid caustic soda pumped into the high-level kettle by a hydraulic pump into the reaction kettle with the pyrrolidone under the condition of stirring, heating to 55-65 ℃ by steam, and preserving heat for 1-2 hours;
s2: cooling to 10 ℃ by using cold liquid, discharging, and filtering to obtain a gamma-aminobutyric acid sodium filtrate;
s3: entering a continuous fluid separation device for conversion, namely entering the gamma-aminobutyric acid sodium dialysate into a continuous fluid separation device for ion exchange by a continuous acidic cation exchange column to convert the gamma-aminobutyric acid sodium into a gamma-aminobutyric acid solution;
s4: concentrating by reverse osmosis, namely concentrating the gamma-aminobutyric acid solution from the continuous fluid separation device by a reverse osmosis system to obtain gamma-aminobutyric acid concentrated solution;
s5: introducing crystals, and adding gamma-aminobutyric acid seed crystals into the gamma-aminobutyric acid concentrated solution to obtain gamma-aminobutyric acid;
s6: filtering and drying the gamma-aminobutyric acid to obtain clean gamma-aminobutyric acid;
s7: adding gamma-aminobutyric acid, melatonin, NMN, NAD, sucrose and lactose into a reaction kettle, heating by using steam, and starting a stirrer for stirring;
s8: then adding hydroxypropyl methylcellulose, magnesium stearate and silicon dioxide, continuing stirring, gradually adding starch slurry while stirring, and continuously stirring to a viscous state;
s9: then heating and drying, continuously stirring until solid, and then crushing into powder with 80-100 meshes by using a crusher;
s10: the powder is then added with a binder and pressed into granules using a die.
In the S3, the acidic cation is exchanged by using a sodium chloride solution with the concentration of 20-25% as a matrix.
In the step S7, the heating temperature is 50 ℃, the heating time is 15-20 minutes, and the rotation speed of the stirrer is 800-100 r/min.
In the S8, the stirring speed is 300-500 r/min.
Example 3:
the formula of the gamma-aminobutyric acid oral-aid functional food mainly comprises the following components in parts by weight: pyrrolidone: 5.8-6.2, alkali liquor: 2.8-3.2, melatonin: 6-7, NMN: 0.8-1, hydroxypropyl methylcellulose 3.5-5.5, magnesium stearate: 5.2-5.8, NAD: 0.8-1.2, silica: 0.8-1.2, sucrose: 0.45-0.55, lactose: 0.45-0.55, starch slurry: 0.9-1.1.
The alkali liquor is 20-25% sodium hydroxide solution or 20-25% potassium hydroxide solution.
A preparation method of a formula of a gamma-aminobutyric acid oral-aid functional food comprises the following steps:
s1: pumping the pyrrolidone into a reaction kettle by a pump, dripping the liquid caustic soda pumped into the high-level kettle by a hydraulic pump into the reaction kettle with the pyrrolidone under the condition of stirring, heating to 55-65 ℃ by steam, and preserving heat for 1-2 hours;
s2: cooling to 10 ℃ by using cold liquid, discharging, and filtering to obtain a gamma-aminobutyric acid sodium filtrate;
s3: entering a continuous fluid separation device for conversion, namely entering the gamma-aminobutyric acid sodium dialysate into a continuous fluid separation device for ion exchange by a continuous acidic cation exchange column to convert the gamma-aminobutyric acid sodium into a gamma-aminobutyric acid solution;
s4: concentrating by reverse osmosis, namely concentrating the gamma-aminobutyric acid solution from the continuous fluid separation device by a reverse osmosis system to obtain gamma-aminobutyric acid concentrated solution;
s5: introducing crystals, and adding gamma-aminobutyric acid seed crystals into the gamma-aminobutyric acid concentrated solution to obtain gamma-aminobutyric acid;
s6: filtering and drying the gamma-aminobutyric acid to obtain clean gamma-aminobutyric acid;
s7: adding gamma-aminobutyric acid, melatonin, NMN, NAD, sucrose and lactose into a reaction kettle, heating by using steam, and starting a stirrer for stirring;
s8: then adding hydroxypropyl methylcellulose, magnesium stearate and silicon dioxide, continuing stirring, gradually adding starch slurry while stirring, and continuously stirring to a viscous state;
s9: then heating and drying, continuously stirring until solid, and then crushing into powder with 80-100 meshes by using a crusher;
s10: the powder is then added with a binder and pressed into granules using a die.
In the S3, the acidic cation is exchanged by using a sodium chloride solution with the concentration of 20-25% as a matrix.
In the step S7, the heating temperature is 50 ℃, the heating time is 15-20 minutes, and the rotation speed of the stirrer is 800-100 r/min.
In the S8, the stirring speed is 300-500 r/min.
Example 4:
the formula of the gamma-aminobutyric acid oral-aid functional food mainly comprises the following components in parts by weight: pyrrolidone: 5. alkali liquor: 3. melatonin: 6.5, NMN: 0.9, hypromellose 4.5, magnesium stearate: 5.5, NAD: 1. silicon dioxide: 1. sucrose: 0.5, lactose: 0.5, starch slurry: 1.
the alkali liquor is 20-25% sodium hydroxide solution or 20-25% potassium hydroxide solution.
A preparation method of a formula of a gamma-aminobutyric acid oral-aid functional food comprises the following steps:
s1: pumping the pyrrolidone into a reaction kettle by a pump, dripping the liquid caustic soda pumped into the high-level kettle by a hydraulic pump into the reaction kettle with the pyrrolidone under the condition of stirring, heating to 55-65 ℃ by steam, and preserving heat for 1-2 hours;
s2: cooling to 10 ℃ by using cold liquid, discharging, and filtering to obtain a gamma-aminobutyric acid sodium filtrate;
s3: entering a continuous fluid separation device for conversion, namely entering the gamma-aminobutyric acid sodium dialysate into a continuous fluid separation device for ion exchange by a continuous acidic cation exchange column to convert the gamma-aminobutyric acid sodium into a gamma-aminobutyric acid solution;
s4: concentrating by reverse osmosis, namely concentrating the gamma-aminobutyric acid solution from the continuous fluid separation device by a reverse osmosis system to obtain gamma-aminobutyric acid concentrated solution;
s5: introducing crystals, and adding gamma-aminobutyric acid seed crystals into the gamma-aminobutyric acid concentrated solution to obtain gamma-aminobutyric acid;
s6: filtering and drying the gamma-aminobutyric acid to obtain clean gamma-aminobutyric acid;
s7: adding gamma-aminobutyric acid, melatonin, NMN, NAD, sucrose and lactose into a reaction kettle, heating by using steam, and starting a stirrer for stirring;
s8: then adding hydroxypropyl methylcellulose, magnesium stearate and silicon dioxide, continuing stirring, gradually adding starch slurry while stirring, and continuously stirring to a viscous state;
s9: then heating and drying, continuously stirring until solid, and then crushing into powder with 80-100 meshes by using a crusher;
s10: the powder is then added with a binder and pressed into granules using a die.
In the S3, the acidic cation is exchanged by using a sodium chloride solution with the concentration of 20-25% as a matrix.
In the step S7, the heating temperature is 50 ℃, the heating time is 15-20 minutes, and the rotation speed of the stirrer is 800-100 r/min.
In the S8, the stirring speed is 300-500 r/min.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (9)
1. The gamma-aminobutyric acid oral-aid functional food formula is characterized by mainly comprising the following components in parts by weight: pyrrolidone: 5-7, alkali liquor: 2-4, melatonin: 4.5-8.5, NMN: 0.4-1.6, hydroxypropyl methylcellulose 2-6, magnesium stearate: 3-7, NAD: 0.4-1.6, silica: 0.4-1.6, sucrose: 0.2-0.8, lactose: 0.2-0.8, starch slurry: 0.7-1.3.
2. The formulation of claim 1, wherein the pyrrolidone is: 5.5-6.5, alkali liquor: 2.5-3.5, melatonin: 5-8, NMN: 0.6-1.2, hydroxypropyl methylcellulose 3-5, magnesium stearate: 5-6, NAD: 0.6-1.4, silica: 0.6-1.4, sucrose: 0.4-0.6, lactose: 0.4-0.6, starch slurry: 0.8-1.2.
3. The formulation of claim 1, wherein the pyrrolidone is: 5.8-6.2, alkali liquor: 2.8-3.2, melatonin: 6-7, NMN: 0.8-1, hydroxypropyl methylcellulose 3.5-5.5, magnesium stearate: 5.2-5.8, NAD: 0.8-1.2, silica: 0.8-1.2, sucrose: 0.45-0.55, lactose: 0.45-0.55, starch slurry: 0.9-1.1.
4. The formulation of claim 1, wherein the pyrrolidone is: 5. alkali liquor: 3. melatonin: 6.5, NMN: 0.9, hypromellose 4.5, magnesium stearate: 5.5, NAD: 1. silicon dioxide: 1. sucrose: 0.5, lactose: 0.5, starch slurry: 1.
5. the formulation and preparation method of gamma-aminobutyric acid servo functional food as claimed in any one of claims 1 to 4, wherein the alkali solution is 20% to 25% sodium hydroxide solution or 20% to 25% potassium hydroxide solution.
6. The preparation method of the gamma-aminobutyric acid oral-aid functional food formula is characterized by comprising the following steps of:
s1: pumping the pyrrolidone into a reaction kettle by a pump, dripping the liquid caustic soda pumped into the high-level kettle by a hydraulic pump into the reaction kettle with the pyrrolidone under the condition of stirring, heating to 55-65 ℃ by steam, and preserving heat for 1-2 hours;
s2: cooling to 10 ℃ by using cold liquid, discharging, and filtering to obtain a gamma-aminobutyric acid sodium filtrate;
s3: entering a continuous fluid separation device for conversion, namely entering the gamma-aminobutyric acid sodium dialysate into a continuous fluid separation device for ion exchange by a continuous acidic cation exchange column to convert the gamma-aminobutyric acid sodium into a gamma-aminobutyric acid solution;
s4: concentrating by reverse osmosis, namely concentrating the gamma-aminobutyric acid solution from the continuous fluid separation device by a reverse osmosis system to obtain gamma-aminobutyric acid concentrated solution;
s5: introducing crystals, and adding gamma-aminobutyric acid seed crystals into the gamma-aminobutyric acid concentrated solution to obtain gamma-aminobutyric acid;
s6: filtering and drying the gamma-aminobutyric acid to obtain clean gamma-aminobutyric acid;
s7: adding gamma-aminobutyric acid, melatonin, NMN, NAD, sucrose and lactose into a reaction kettle, heating by using steam, and starting a stirrer for stirring;
s8: then adding hydroxypropyl methylcellulose, magnesium stearate and silicon dioxide, continuing stirring, gradually adding starch slurry while stirring, and continuously stirring to a viscous state;
s9: then heating and drying, continuously stirring until solid, and then crushing into powder with 80-100 meshes by using a crusher;
s10: the powder is then added with a binder and pressed into granules using a die.
7. The method for preparing a gamma-aminobutyric acid servo-assisted functional food formulation according to claim 6, wherein in S3, the acidic cation is exchanged by using a sodium chloride solution with a concentration of 20-25% as a matrix.
8. The method as claimed in claim 6, wherein the heating temperature of S7 is 50 ℃, the heating time is 15-20 minutes, and the rotation speed of the blender is 800-100 r/min.
9. The method as claimed in claim 6, wherein the stirring speed of S8 is 300-500 r/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010601265.2A CN112167630A (en) | 2020-06-29 | 2020-06-29 | Gamma-aminobutyric acid oral-aid functional food formula and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010601265.2A CN112167630A (en) | 2020-06-29 | 2020-06-29 | Gamma-aminobutyric acid oral-aid functional food formula and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112167630A true CN112167630A (en) | 2021-01-05 |
Family
ID=73919705
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010601265.2A Pending CN112167630A (en) | 2020-06-29 | 2020-06-29 | Gamma-aminobutyric acid oral-aid functional food formula and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112167630A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113262237A (en) * | 2021-06-09 | 2021-08-17 | 云南维他源生物科技有限公司 | AGNM composition, preparation and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100999479A (en) * | 2007-01-16 | 2007-07-18 | 开原亨泰精细化工厂 | Preparation process of amino tyracid |
| JP2008017703A (en) * | 2006-07-10 | 2008-01-31 | Unitika Ltd | METHOD FOR PRODUCING FOOD COMPRISING gamma-AMINOBUTYRIC ACID AND ORNITHINE |
| CN102381998A (en) * | 2011-11-10 | 2012-03-21 | 江苏远洋药业股份有限公司 | Synthetic method of gamma-aminobutyric acid |
| CN106070958A (en) * | 2016-07-06 | 2016-11-09 | 慧谷生命科技湖北有限公司 | A kind of gamma aminobutyric acid sheet and preparation method thereof |
| CN106692751A (en) * | 2016-12-29 | 2017-05-24 | 北京康比特体育科技股份有限公司 | Composition for improving exercise-induced insomnia |
| CN109045158A (en) * | 2018-10-12 | 2018-12-21 | 泓博元生命科技（深圳）有限公司 | A kind of composition and preparation method and application containing NMN |
| CN109820905A (en) * | 2019-03-06 | 2019-05-31 | 北京坤秋健康科技有限公司 | A kind of pharmaceutical composition and its application for treating insomnia |
-
2020
- 2020-06-29 CN CN202010601265.2A patent/CN112167630A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008017703A (en) * | 2006-07-10 | 2008-01-31 | Unitika Ltd | METHOD FOR PRODUCING FOOD COMPRISING gamma-AMINOBUTYRIC ACID AND ORNITHINE |
| CN100999479A (en) * | 2007-01-16 | 2007-07-18 | 开原亨泰精细化工厂 | Preparation process of amino tyracid |
| CN102381998A (en) * | 2011-11-10 | 2012-03-21 | 江苏远洋药业股份有限公司 | Synthetic method of gamma-aminobutyric acid |
| CN106070958A (en) * | 2016-07-06 | 2016-11-09 | 慧谷生命科技湖北有限公司 | A kind of gamma aminobutyric acid sheet and preparation method thereof |
| CN106692751A (en) * | 2016-12-29 | 2017-05-24 | 北京康比特体育科技股份有限公司 | Composition for improving exercise-induced insomnia |
| CN109045158A (en) * | 2018-10-12 | 2018-12-21 | 泓博元生命科技（深圳）有限公司 | A kind of composition and preparation method and application containing NMN |
| CN109820905A (en) * | 2019-03-06 | 2019-05-31 | 北京坤秋健康科技有限公司 | A kind of pharmaceutical composition and its application for treating insomnia |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113262237A (en) * | 2021-06-09 | 2021-08-17 | 云南维他源生物科技有限公司 | AGNM composition, preparation and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102816188B (en) | Production technology of sucralose | |
| CN101863783A (en) | Method for separating and purifying gamma-aminobutyric acid (GABA) from glutamine decarboxylase enzymolysis liquid | |
| CN108822163A (en) | A kind of synthesis circulation producing method of D-Glucosamine Hydrochloride | |
| CN102690846A (en) | Method for catalytically synthesizing gamma-aminobutyric acid from glutamate biological solid-phase enzyme | |
| CN101787385B (en) | Preparation method for medical glucose with ultrahigh purity | |
| CN109295134A (en) | A kind of production method of high-content, high yield L-AA glucoside | |
| CN103642853A (en) | Novel process for extracting L-malic acid | |
| CN102250261A (en) | New method for producing iron dextran | |
| CN103667375A (en) | Method for preparing sodium gluconate by adopting aspergillus niger fermentation method | |
| CN112167630A (en) | Gamma-aminobutyric acid oral-aid functional food formula and preparation method | |
| CN103265467B (en) | A kind of crystallisation by cooling refines the method for L-PROLINE | |
| CN101863819A (en) | Method for preparing magnesium L-pyroglutamate | |
| CN103922951A (en) | Method for extracting leucine by utilizing corn protein powder | |
| CN105061289B (en) | A kind of method for preparing pharmaceutical grade L tryptophans | |
| CN105859642B (en) | A kind of method for extraction and purification of Tetramethylpyrazine | |
| CN111892498A (en) | Method for extracting L-malic acid | |
| CN107384733A (en) | A kind of method that spontaneous fermentation prepares sugarcane vinegar | |
| CN102659566A (en) | Production technology of medicinal anhydrous citric acid | |
| CN106674360A (en) | Purifying method of resistant dextrin | |
| CN108299220B (en) | Method for extracting L-4-hydroxyisoleucine from fermentation catalytic liquid | |
| CN110468169A (en) | A kind of method of corncob production L-arabinose | |
| CN101781615B (en) | Method for preparing ginger beer | |
| CN102381998A (en) | Synthetic method of gamma-aminobutyric acid | |
| CN110627639A (en) | Preparation method of ketophenylalanine calcium | |
| CN105861251B (en) | A kind of blueberry mixed health wine product |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20210105 |