CN112121082A

CN112121082A - Chinese herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy

Info

Publication number: CN112121082A
Application number: CN202011164412.0A
Authority: CN
Inventors: 肖京平; 肖丽萍; 王昀子; 汤云凯; 肖友旭
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-10-27
Filing date: 2020-10-27
Publication date: 2020-12-25

Abstract

The invention relates to a Chinese herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy, which comprises the following raw material components: 800 portions of fortune's drynaria rhizome, 800 portions of east Asian tree fern rhizome, 1200 portions of epimedium, 1600 portions of malaytea scurfpea fruit, 2400 portions of glossy privet fruit, 1600 portions of eucommia bark, 3000 portions of eucommia bark, 2400 portions of mirabilitum dehydratum, 3600 portions of mirabilitum dehydratum, 1200 portions of wild artemisia leaf, 3000 portions of Huoxuedan and 800 portions of camphor tree leaves. The Chinese herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy has obvious treatment effects on various osteoarthropathy including ankylosing spondylitis, rheumatoid arthritis, hyperosteogeny, osteoporosis, herniated disc, scapulohumeral periarthritis, cervical spondylitis and quadriplegia, especially solves the world problem of ankylosing spondylitis and rheumatoid arthritis, and has important clinical popularization significance.

Description

Chinese herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a Chinese herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy and a preparation method thereof.

Background

Bone and joint diseases including degenerative arthritis, bursitis, synovitis, cervical spondylosis, lumbar spondylosis, scapulohumeral periarthritis, hyperosteogeny, rheumatic arthritis, ankylosing spondylitis, rheumatoid arthritis, and femoral head necrosis. The traditional Chinese medicine has more schemes for treating osteoarticular diseases, but different treatment mechanisms and different compositions have larger difference on the treatment effect of different diseases, and the treatment effect of the existing traditional Chinese medicine treatment scheme is not ideal in the aspects of ankylosing spondylitis and rheumatoid arthritis at present.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for effectively treating various osteoarticular diseases including ankylosing spondylitis and rheumatoid arthritis, so as to solve the limitation of the existing medicines for treating the osteoarticular diseases in the aspect of treating the two diseases and expand the treatment range of the existing osteoarticular diseases.

In order to achieve the purpose, the invention adopts the following technical scheme:

a Chinese herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy comprises the following raw material components: 800 portions of fortune's drynaria rhizome, 800 portions of east Asian tree fern rhizome, 1200 portions of epimedium, 1600 portions of malaytea scurfpea fruit, 2400 portions of glossy privet fruit, 1600 portions of eucommia bark, 3000 portions of eucommia bark, 2400 portions of mirabilitum dehydratum, 3600 portions of mirabilitum dehydratum, 1200 portions of wild artemisia leaf, 3000 portions of Huoxuedan and 800 portions of camphor tree leaves. Preferably, the Chinese herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy comprises the following raw material components: 1000 parts of drynaria rhizome, 1000 parts of cibotium barometz, 1000 parts of epimedium herb, 2000 parts of malaytea scurfpea fruit, 2000 parts of glossy privet fruit, 2500 parts of eucommia bark, 3000 parts of glauber salt, 1000 parts of mugwort leaf, 2500 parts of red sage root and 500 parts of camphor tree leaf.

The bone joint diseases are caused by the invasion of kidney deficiency wind, cold and dampness to the human body, and stagnation of meridian and joint obstruction (metabolite deposition), which causes joint swelling and pain and rigid movement limitation. The research of the inventor is combined with the B ultrasonic inspection technology to discover that: for patients with diseases of bones and joints, there are plenty of stones, crystals, lumps and spaces in the kidney, which cause the kidney to enlarge and deform, even become fuzzy. Calculus, crystallization and agglomeration occupy space in kidney, which affects normal filtering and excreting function of kidney, so that metabolite (urate crystallite) in blood is not completely filtered in kidney and discharged from urine, and returns to blood circulation to deposit in bone joint, thus causing various bone joint diseases. According to the principle that the kidney governs bones and muscles, combined with B-ultrasonic examination and combined with the comprehensive consideration of pathological change parts and individual differences, the fundamental treatment method for treating osteoarticular diseases by using the traditional Chinese medicine for dissolving, dredging and regulating has the effect of treating both principal and secondary aspects of diseases.

The inventor has found that, based on the fact that the medicine for tonifying kidney and strengthening bone can achieve better dredging and regulating effects, the inventor has found that CN106309566A has better curative effects on cardiovascular and cerebrovascular diseases and general osteoarticular diseases including osteoporosis, hyperosteogeny, intervertebral disc protrusion, scapulohumeral periarthritis, cervical spondylitis and the like, but has little effect on the aspects of world difficult problems of ankylosing spondylitis and rheumatoid arthritis. The invention is mainly prepared from medicaments for tonifying kidney and strengthening bones, namely rhizoma cibotii, fructus psoraleae and eucommia bark, as well as medicaments for tonifying kidney and strengthening yang, namely epimedium, and is assisted by glossy privet fruit as a medicament for nourishing yin and tonifying kidney, wild mugwort leaves for warming spleen and stomach and dispelling cold, and red sage root and camphor tree leaves for activating blood circulation, clearing channels and eliminating dampness, and is assisted by medicaments for clearing heat, purging fire, promoting urination and defecation, namely compound mirabilitum and sodium sulfate for excreting metabolites of liver, kidney and gastrointestinal tract stasis. Has the effects of nourishing yin, invigorating kidney, tonifying yang, strengthening bone, warming spleen and stomach, dispelling cold, promoting blood circulation, dredging channels, and regulating body functions. The raw material composition and the proportion of the invention are obtained by repeated optimization for dozens of times, for example, the eucommia bark can enhance the functions of tonifying kidney and strengthening bones, and the blood-activating pill and the camphor tree leaves can enhance the effects of activating blood and dissolving stasis, dredging meridian and blood, dispelling cold and removing dampness, and warming meridians and relieving pain. However, in the experiments, the inventor also tries to add achyranthes root, teasel root and cistanche to replace eucommia bark, safflower, ligusticum wallichii and peach kernel to replace Huoxue Dan and radix angelicae pubescentis, Chinese starjasmine stem, clematis root and mulberry twig to replace camphor tree leaves, but the clinical symptom improvement effect cannot be obtained. Analysis shows that in the combination, various raw materials interact to take effect, the raw material combination is more reasonable, and the proportion is more scientific. The composition can enhance resistance, improve immunity, purify blood, discharge urate crystal stones deposited in bone joints by a method of tonifying kidney and strengthening bone, promoting blood circulation to remove blood stasis, dispelling wind and removing dampness, warming channels and dredging collaterals, enter blood circulation, filter from kidney and discharge urine. So that the pathogenic factors do not invade and stay. A large number of clinical test results show that the traditional Chinese medicine composition has obvious effects on ankylosing spondylitis, rheumatoid arthritis, hyperosteogeny, osteoporosis, intervertebral disc protrusion, scapulohumeral periarthritis, cervical spondylitis and quadriplegia by being combined with the administration of the traditional Chinese medicine composition on the basis of the patent of dissolving calculus and crystallizing and caking in the kidney. The composition solves the limitation of the prior art on the treatment effect in the aspects of ankylosing spondylitis and rheumatoid arthritis, expands the treatment scope of osteoarticular diseases and has clinical popularization significance.

According to the Chinese herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy, the dosage form of the Chinese herbal medicine composition is an internal dosage form suitable for medicinal use, including but not limited to capsules, tablets and granules, and preferably capsules.

The invention also provides a preparation method of the Chinese herbal medicine capsule for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy, which comprises the following steps: (1) respectively taking the traditional Chinese medicine raw materials, respectively crushing to obtain fine powder of each raw material, preferably crushing to the particle size of 200-300 meshes for later use; (2) mixing rhizoma Drynariae fine powder, rhizoma Cibotii fine powder, fructus Psoraleae fine powder, fructus Ligustri Lucidi fine powder and Eucommiae cortex fine powder to obtain mixed medicinal powder; adding white spirit into the mixed medicinal powder, uniformly stirring, and sealing and placing for primary fermentation; (3) adding the rest fine powder into the raw materials after the first fermentation, adding the Chinese liquor again, stirring uniformly, sealing and placing for the second fermentation, and then sequentially drying, crushing and subpackaging into capsule shells to obtain the Chinese herbal medicine capsule for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy. The Chinese herbal medicine of the invention contains a plurality of medicinal effective components including aromatic volatile components, and can be dissolved out by adding white spirit and sealing fermentation. The inventor researches and discovers that the effective components of rhizoma drynariae, cibotium barometz, fructus psoraleae, glossy privet fruit and eucommia ulmoides rhizome and fruit seeds are slowly dissolved out and are not ideal in blending and fermentation effects with other raw materials, so that the method that the raw materials are crushed and mixed firstly, then the white spirit is added for pre-fermentation, and then the other raw materials are added for secondary fermentation is adopted. Through the two times of fermentation, the fermentation can be more sufficient, so that the effective ingredients of the medicine are infiltrated out, the effects of entering bone joints and removing urate crystallite in the bone joints are improved. Preferably, in the step (2), the mass ratio of the mixed medicinal powder to the white spirit is 10:1-3, the white spirit is 60-degree sorghum white spirit, the temperature of the first fermentation is 30-35 ℃, and the time of the first fermentation is 80-100 days. In the step (3), the adding amount of the white spirit accounts for 4-5% of the total mass of the raw materials and the rest raw materials after the first fermentation, the white spirit is 52-54 degrees sorghum white spirit, the temperature of the second fermentation is 30-35 ℃, and the time of the second fermentation is 48-72 hours. The drying is preferably carried out by microwave heating, the power of the microwave heating and drying is 1-2kw, and the drying time is 15-25 min. The crushing is carried out until the particle size is 300-500 meshes.

The invention has the beneficial effects that:

the invention relates to a Chinese herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy, which is prepared from drynaria rhizome, east Asian tree fern rhizome, epimedium herb, malaytea scurfpea fruit, glossy privet fruit, eucommia bark, glauber salt, wild artemisia leaf, glechoma longituba, camphor leaf and white spirit in a reasonable weight ratio, wherein the drynaria rhizome, east Asian tree fern rhizome, malaytea scurfpea fruit, eucommia bark and epimedium herb are taken as main raw materials, and the medicinal materials mainly comprise ligustrum japonicum for nourishing yin and tonifying kidney, wild artemisia leaf for warming middle-jiao and dispelling cold, and the blood activating pill and camphor leaf for activating blood circulation and clearing damp are used as auxiliary materials, and the glauber salt powder for clearing heat and purging fire and promoting urination and defecation. Has the effects of nourishing yin, invigorating kidney, tonifying yang, strengthening bone, warming spleen and stomach, dispelling cold, dredging and regulating. A large number of clinical test results show that the Chinese herbal medicine has obvious treatment effects on various osteoarticular diseases including ankylosing spondylitis, rheumatoid arthritis, hyperosteogeny, osteoporosis, intervertebral disc herniation, scapulohumeral periarthritis, cervical spondylitis and quadriplegia, especially solves the worldwide problem of ankylosing spondylitis and rheumatoid arthritis, and has important clinical popularization significance.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention. In the following examples, 1 part by weight represents 1 g.

Example 1

The embodiment provides a Chinese herbal medicine capsule for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy, which is prepared from the following raw material components:

1000 parts of drynaria rhizome, 1000 parts of cibotium barometz, 1000 parts of epimedium herb, 2000 parts of malaytea scurfpea fruit, 2000 parts of glossy privet fruit, 2500 parts of eucommia bark, 3000 parts of glauber salt, 1000 parts of mugwort leaf, 2500 parts of red sage root and 500 parts of camphor tree leaf.

The preparation method of the Chinese herbal medicine capsule for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy in the embodiment comprises the following steps:

(1) respectively taking the traditional Chinese medicine raw materials, and respectively crushing to obtain raw material fine powder with the particle size of 270 meshes for later use;

(2) mixing rhizoma Drynariae fine powder, rhizoma Cibotii fine powder, fructus Psoraleae fine powder, fructus Ligustri Lucidi fine powder and Eucommiae cortex fine powder to obtain mixed medicinal powder; adding 60-degree sorghum liquor (10: 2) into the mixed medicinal powder, stirring, sealing, and fermenting at 30 deg.C for 90 days;

(3) adding the rest raw material fine powder into the raw materials after the first fermentation, then adding 52-degree sorghum liquor accounting for 4% of the total mass of the raw materials, uniformly stirring, sealing and placing, fermenting for 60 hours at 30 ℃, then heating and drying for 20 minutes by 1kw of microwave to ensure that the water content is lower than 6%, crushing to fine powder with the particle size of 400 meshes after the completion, and subpackaging into 0# capsules, wherein each capsule is 0.5g, and the Chinese herbal medicine capsules for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy are obtained.

Example 2

800 parts of drynaria rhizome, 1200 parts of cibotium barometz, 800 parts of epimedium herb, 2400 parts of malaytea scurfpea fruit, 1600 parts of glossy privet fruit, 3000 parts of eucommia bark, 2400 parts of glauber salt, 1200 parts of wild wormwood leaf, 2000 parts of glechoma longituba and 800 parts of camphor tree leaf.

(1) respectively taking the traditional Chinese medicine raw materials, and respectively crushing to obtain raw material fine powder with the particle size of 200 meshes for later use;

(2) mixing rhizoma Drynariae fine powder, rhizoma Cibotii fine powder, fructus Psoraleae fine powder, fructus Ligustri Lucidi fine powder and Eucommiae cortex fine powder to obtain mixed medicinal powder; adding 60-degree sorghum liquor (10: 1) into the mixed medicinal powder, stirring, sealing, and fermenting at 35 deg.C for 80 days;

(3) adding the rest raw material fine powder into the raw materials after the first fermentation, then adding 54-degree sorghum liquor accounting for 5% of the total mass of the raw materials, uniformly stirring, sealing and placing, fermenting for 48h at 35 ℃, then heating and drying for 15min by 2kw microwave to ensure that the water content is lower than 6%, crushing to fine powder with the particle size of 300 meshes after the completion, and subpackaging into 0# capsules, wherein each capsule is 0.5g, and the Chinese herbal medicine capsules for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy are obtained.

Example 3

1200 parts of drynaria rhizome, 800 parts of cibotium barometz, 1200 parts of epimedium herb, 1600 parts of malaytea scurfpea fruit, 2400 parts of glossy privet fruit, 2000 parts of eucommia bark, 3600 parts of mirabilitum glauberculosum, 800 parts of wild artemisia leaf, 3000 parts of Huoxue Dan and 300 parts of camphor tree leaves.

(1) respectively taking the traditional Chinese medicine raw materials, and respectively crushing to obtain raw material fine powder with the particle size of 300 meshes for later use;

(2) mixing rhizoma Drynariae fine powder, rhizoma Cibotii fine powder, fructus Psoraleae fine powder, fructus Ligustri Lucidi fine powder and Eucommiae cortex fine powder to obtain mixed medicinal powder; adding 60-degree sorghum liquor (10: 3) into the mixed medicinal powder, stirring, sealing, and fermenting at 30 deg.C for 100 days;

(3) adding the rest raw material fine powder into the raw materials after the first fermentation, then adding 54-degree sorghum liquor accounting for 5% of the total mass of the raw materials, uniformly stirring, sealing and placing, fermenting for 72 hours at 30 ℃, then heating and drying for 25min by 1kw of microwaves to ensure that the water content is lower than 6%, crushing to fine powder with the particle size of 500 meshes after the completion, and filling into 0# capsules, wherein each capsule is 0.5g, thus obtaining the Chinese herbal medicine capsules for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy.

Comparative example

The present comparative example provides a Chinese herbal capsule for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy, which is different from example 1 in that achyranthes bidentata is used instead of eucommia ulmoides and trachelospermi caulis is used instead of camphor tree leaves. Specifically, the capsule of the comparative example is prepared from the following raw material components: 1000 parts of drynaria rhizome, 1000 parts of cibotium barometz, 1000 parts of epimedium herb, 2000 parts of malaytea scurfpea fruit, 2000 parts of glossy privet fruit, 2500 parts of twotooth achyranthes root, 3000 parts of glauber salt, 1000 parts of mugwort leaf, 2500 parts of red sage root and 500 parts of Chinese starjasmine stem.

Typical cases

Case one: goujin, male, 25 years old. Initial diagnosis in 3 days 4 and 2020, self-complaint: the patients with soreness of waist and back pain, aggravation in the morning and limited activity in 2016 have a plurality of medical visits, and are not treated effectively by traditional Chinese medicines and western medicines given for rheumatism and lumbar muscle strain, acupuncture and electrotherapy and the like, and are willing to eat carbonated beverages and bagged snacks. Ankylosing spondylitis was confirmed by X-ray and CT examination in western university of sichuan hospital from 11/month 2 to 11/month 12 in 2019. And is treated by Anbonuo (recombinant human II type tumor necrosis factor receptor-antibody fusion protein for injection) in orthopaedics rheumatoid arthritis department of western China hospital. Thirty-two needles were treated twice a week for four months. No obvious improvement is seen. And (3) diagnosis: b ultrasonic examination: the kidney-yang deficiency is marked by calculus, crystallization, agglomeration, deformation and cloudiness. The liver is rough, the liver is damaged due to the agglomeration and stasis in the bile duct, the tubule, the liver and the bile duct. No obvious abnormality was observed in other organs. Prescription: dissolve kidney calculus Capsule (CN102755456B)3 bottles (120 capsules each, 0.5g each) three times a day, 5 capsules each time. The second diagnosis is given 5/month/2/2020, the change of kidney seen in B-ultrasonic is not obvious, and the prescription is as follows: the capsules for treating osteoarticular diseases of the present invention were administered in addition to the aforementioned treatment regimen (comparative example); the change of the kidney of the three-diagnosis B-ultrasonic is still not obvious after 5-month and 28-day 2020, and the prescription is further adjusted according to the weakness of the patient. Prescription: 1 bottle of each kidney stone dissolving capsule and 1 bottle of the Chinese herbal medicine capsule (example 1) for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy of the invention are taken three times a day, 3 capsules each time. The prescription is taken 3 times continuously on 6-month and 13-day, 6-month and 26-day, and 7-month and 12-day (three times per prescription), and B-ultrasonic examination is performed again on 7-month and 26-day. For B-mode ultrasonography: the patients have clear kidney and small amount of calculus in the kidney, and are recommended to continue taking the medicine. The medicine is taken once again in the front on 8 months and 7 days. The patient is retested for 8 months and 23 days, and the double kidneys are clear and the shape is normal in B ultrasonic examination. The patient body returns to normal, and joints of the whole body have no swelling and pain. The bow can move freely when bending waist and back. The mental state is good, (the patient has lost the hope of survival when ankylosing spondylitis was diagnosed) the condition improves, the life rule, and the appetite of the patient increases from 78 jin to 88 jin after the condition is relieved. According to the examination and treatment effect of the patient, the patient is advised to continue conditioning for a period of time, consolidate the curative effect and prevent relapse.

Case two: gong Yi and Nu in 54 years old. First diagnosis in 6 months and 18 days in 2020. The patient can not walk in a standing way and carries the family members to the examination bed. The patients complain about pain and swelling of the joints of the fingers and the fingers, soreness of the waist and back, aggravation at night, stiff small joints and limited movement for over three decades, and the patients are examined for the positive rheumatoid factors in many places (270, the normal range is less than 15.9). Fast blood sedimentation and high uric acid. If the medicine is taken for a long time, the diclofenac sodium can relieve pain and the prednisone can relieve pain. Pain aggravates and movement is limited in the last three years, and labor is lost. The traditional Chinese medicine composition is difficult to live and live, and has no treatment effect after long-term treatment in rheumatism immunity departments in a plurality of places and hospitals. And (3) diagnosis: the enlargement of both kidneys seen in type-B ultrasonography, deformation, blur, large amount of stones, crystallization and agglomeration. Prescription: 1 bottle (120 capsules each, 0.5g capsule each) of kidney stone dissolving capsules (CN102755456B) is given, three times a day, 6 capsules each time. It is recommended to take the medicine for one week. The patient has no obvious change of the two kidneys through B-ultrasonic examination, and the pain of the patient is severe, so that the pain is required to be relieved quickly. Receiving a patient request for an improved treatment regimen, prescription: the Chinese herbal medicine capsules (example 1) for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy, which dissolve kidney stone capsules and are disclosed by the invention, are respectively taken twice a day, 5 capsules each time, and are alternately taken once every four hours in 1 bottle. Three diagnoses are made in 7, 22 and 2020, and the patient has no severe pain after the patient complains of the second prescription and takes the second prescription for one week. The B-ultrasonic examination is given, and the double kidney of the patient can be divided into separate branches. The crystallization and agglomeration of the stones in the kidney are not improved obviously. It is recommended to continue taking the medicine according to the prescription of 7 months and 13 days, and the dosage is not changed. Four diagnostic methods 8, 9 days in 2020: after the patient takes the medicine for 24 days according to the second formula, the effect is obvious, and the joint is not painful except for the pain in the activity. The life can be self-care, people do not need to help to wear clothes, eat and defecate, and people can walk in short distance. And B ultrasonic examination shows that the shape of the two kidneys is recovered to be normal, and metabolic products such as part of stones, crystals and the like exist in the kidneys. It is recommended to continue taking as before. Five diagnoses in 8-month and 23-day of 2020: after the medicine is taken by a patient, the curative effect is particularly obvious, and the medicine can help housework, cooking and washing clothes and light farm work. But the wrist, the shoulder, the waist and the back of the large joint still have pain. B-ultrasonic recheck: some deposits were left in both kidneys and were taken as before. Six diagnosis in 9/11/2020, the patient walks freely, and all joints are free from pain. The original deformed, swollen and stiff joints are all restored to be normal. Can do slight farm work. B ultrasonic examination: clear kidneys, normal size and morphology. There are stones, crystals and metabolites in the kidney and kidney. In order to consolidate the therapeutic effect, patients are advised to continue to take the medicine less frequently (once a day) for a while to consolidate the therapeutic effect and prevent relapse.

Case three: wangzhi, male, 69 years old. Initial diagnosis in 5/15/2020. Patients complain of lumbar and leg pains caused by pressing sciatic nerves after 8 years of intervertebral disc herniation, and patients are diagnosed and treated in various hospitals and adopt various therapies such as traditional Chinese medicine, western medicine, physical therapy and the like, with good time and bad time. Ischialgia caused by intervertebral disc protrusion causes difficulty in walking. The joints of the fingers and the hands are swollen, deformed and stiff for more than 2 years. Lost labor for many years.

B ultrasonic examination: a large amount of calculus crystals are found in the double kidneys of a patient, and the double kidneys are enlarged and deformed. With liver damage (rough, enlarged, with granular clumps inside, stringy deposits). With vesical calculus, prostatic calculus and prostatic enlargement. The heart is enlarged, falls and the heart muscle is weak. Prescription: dissolve kidney calculus Capsule (CN102755456B)2 bottles (120 capsules per bottle) 3 times per day, 5 capsules each time for 16 days. The medicine is taken 2 times in front on 3 days 6/2020 and 28 days 6/2020. After the patient takes 6 bottles of capsule for dissolving kidney stone, the patient can relieve the self-complaint of the disease and relieve the palpitation and the shortness of breath in 7-month and 13-day diagnosis in 2020. When B-ultrasonic examination is given, the clear part in the double kidneys is not enlarged, but part of metabolic deposits exist. The heart was slightly more reduced and moved up than in the previous examination. One bottle of kidney stone dissolving capsules is given, and five capsules are taken once a day. It is administered at noon. The Chinese herbal medicine capsule (example 1) for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy of the invention is taken in two bottles, each bottle has 120 capsules, twice a day and five capsules each time. It is administered in the morning and evening. Five diagnoses: the effect of the medicine is particularly good after the medicine is taken by patients. Self-complaints: sciatica has already recurred for half a month. The swollen joints of the fingers and the feet become smaller obviously and are not rigid. Can move freely without swelling and pain. The palpitation and shortness of breath are improved obviously, and the patient can move normally and do slight housework. For B-mode ultrasonography, see: clear kidneys, normal shape and size. The heart returned to the normal position in the chest. Continue to apply the drug as before. Six diagnoses: after the patient takes the medicine, the body is good, the spirit is cool, the sciatica, the swelling of the joints of the fingers and the feet are completely eliminated, the movement is free, and the soreness and the pain of the waist and the legs are fully cured. For the B-mode ultrasonography, the two kidneys of the patient are all normal. Early liver damage also heals. The rough liver is already smooth. The enlarged liver has decreased. Granular, and streaky material has also dissipated in the liver. According to the requirements of patients, the curative effect is consolidated, and relapse is prevented, and then three bottles of Chinese herbal medicine capsules (example 2) for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy are provided. Twice a day, five grains each time.

Case four: pi Man, 52 years old. In 2020, the first visit of 27 months 7, was made by X-ray photograph in county hospital, and the fourth lumbar intervertebral disc protruded to the left to press the left sciatic nerve. The lumbar disc herniation is diagnosed to press sciatic nerve, which causes pain of the left lower limb for nearly one year. The acupuncture and moxibustion therapy is not cured in many hospitals. B ultrasonic examination is given according to the condition of the patient: the kidney is enlarged and a large amount of calculi and crystals are in the interior. Metabolizing the sediment. Prescription: the Chinese herbal medicine capsules (example 1) for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy, which dissolve kidney stone capsules and are disclosed by the invention, are respectively taken twice a day, 5 capsules each time, and are alternately taken once every four hours in 1 bottle. After the patient takes the medicine for 12 days, the disease condition is relieved, the pain in the waist and the legs is relieved, the patient thinks that the disease is cured, and the medicine is automatically stopped to 8 months 9, namely the patient feels pain in the waist and the legs due to weight bearing and comes from two diagnostic methods: b ultrasonic examination of double kidney and partial sediment (calculus crystallization) according to the initial diagnosis. The composition is administered twice daily, alternately. Three diagnoses are made in 10 months and 9 days. The patient felt that it had healed, requiring B-mode ultrasound examination: there are also small deposits in the kidneys. In order to consolidate the curative effect and prevent recurrence, one herb is taken. The medicine is taken once a day, five granules each time.

Case five: dou you, male, 38 years old. Initial diagnosis in 26 days 7 and 7 in 2020: a great amount of calculi crystallization, enlargement and deformation of double kidneys can be seen in B-ultrasonic examination. The liver becomes rough and enlarged. Accompanied by arthrocele and deformation of gout for five years. Prescription: 2 bottles of kidney stone dissolving capsules and Chinese herbal medicine capsules (example 1) for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy are taken twice a day, 5 capsules each time, and the capsules are taken alternately for four hours. The treatment course is two, and the curative effect is strengthened by continuously taking the medicine according to the prescription for a period of time to prevent relapse.

Six cases: jia, main, age 49. Initial diagnosis in 7/13/2020: the B-ultrasonic examination shows that the double kidney stone crystallizes to cause the weakness of cardiac muscle, the insufficiency of cerebral blood supply, the numbness of hands and feet and the hyperosteogeny of cervical vertebra. Prescription: 2 bottles of kidney stone dissolving capsules and Chinese herbal medicine capsules (example 1) for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy are taken twice a day, 5 capsules each time, and the capsules are taken alternately for four hours. After three treatment courses, the patients are healed, and the medicine is continuously taken according to the prescription for two bottles (taken once every day) to consolidate the curative effect.

Case seven: he, woman, 72 years old. Initial diagnosis in 19 days 1 month in 2020: double kidney stones, crystallization and agglomeration can be seen in B ultrasonic examination. The liver is slightly damaged and enlarged, with hyperosteogeny. Prescription: dissolve kidney stone capsule 2 bottles, take twice a day, 5 capsules each time. Taking the medicine once according to the prescription of the initial diagnosis in 3 and 18 days in 2020 and 21 and 4 and 21 days in 2020, relieving the symptoms but not showing the symptoms, taking two diagnoses in 5 and 25 days in 2020, and taking 2 bottles of the Chinese herbal medicine capsules (example 1) for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy on the basis of the above treatment scheme, wherein the capsules are taken twice a day, 5 capsules are taken every time, and are taken alternately and once every four hours; the medicine is taken once according to the prescription of the second diagnosis in 3 days 8 months in 2020, the symptoms are completely eliminated, and the body is recovered to be normal. In order to consolidate the curative effect, the medicine is taken for a treatment course. It is recommended to take five capsules each time every day.

Eight cases: bai Zhi, female, 73 years old. Initial diagnosis in 4 months and 4 days in 2020: the B ultrasonic examination shows that the double kidney stone crystallizes, the left kidney enlarges with the myasthenia of the heart muscle, arrhythmia, bone joint gall, intervertebral disc protrusion and sciatica for 3 years. Prescription: 2 bottles of kidney stone dissolving capsules are taken three times a day, 5 capsules are taken each time. Taking two diagnoses in 16 days in 4 months in 2020, dissolving 1 bottle of kidney stone capsules, and taking the medicine in the same way; the two diagnoses are carried out 5 months and 1 day in 2020, kidney stone capsules, Chinese herbal medicine capsules for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy (example 1) of the invention are dissolved, 1 bottle of each capsule is taken twice a day, 5 capsules are taken each time, and the capsules are taken alternately and once every four hours; the body is completely normal at present by taking the medicines once according to the prescription of the second diagnosis at 16 days 5 and 16 days 2020, 27 days 5 and 27 days 2020, 13 days 6 and 13 days 2020, 12 days 7 and 12 months 2020 and 9 months 2020.

Nine cases: qianzhi, male, 40 years old. Initial diagnosis in 6 months and 17 days in 2020: the B-ultrasonic examination shows that a large amount of stones, crystallization and agglomeration exist in the double kidneys, so that the double kidneys are full of stones. With hyperuricemia for 10 years, the joints are swollen, deformed and painful, and the movement is aggravated. Prescription: 2 bottles of kidney stone dissolving capsules are taken three times a day, 5 capsules are taken each time. Taking the medicine once in each of 30 days 6 and 24 days 7 and 24 days 2020, and the prescription is the same as that of the medicine, the symptoms are relieved, and metabolic deposits can still be seen in B-mode ultrasonography; the Chinese herbal medicine capsule for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy (example 1) is taken in 18 days after 8 months in 2020, is taken twice each day, 5 capsules each time, and is taken alternately, once every four hours, and the patients are cured after four treatment courses.

The above description is only for the specific embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.

Claims

1. A Chinese herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy is characterized by comprising the following raw material components:

800 portions of fortune's drynaria rhizome, 800 portions of east Asian tree fern rhizome, 1200 portions of epimedium, 1600 portions of malaytea scurfpea fruit, 2400 portions of glossy privet fruit, 1600 portions of eucommia bark, 3000 portions of eucommia bark, 2400 portions of mirabilitum dehydratum, 3600 portions of mirabilitum dehydratum, 1200 portions of wild artemisia leaf, 3000 portions of Huoxuedan and 800 portions of camphor tree leaves.

2. The Chinese herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy according to claim 1, wherein the raw material components comprise:

3. The herbal medicine for rheumatoid arthritis and ankylosing spondylitis osteoarthropathy as claimed in claim 1, wherein the formulation of said herbal medicine is an oral formulation suitable for pharmaceutical use.

4. The herbal medicine for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy as claimed in claim 3, wherein the dosage form of said herbal medicine is capsule.

5. The method for preparing a Chinese herbal medicine capsule for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy of claim 4, which comprises the following steps:

(1) respectively taking the traditional Chinese medicine raw materials, and respectively crushing to obtain fine powder of each raw material for later use;

(2) mixing rhizoma Drynariae fine powder, rhizoma Cibotii fine powder, fructus Psoraleae fine powder, fructus Ligustri Lucidi fine powder and Eucommiae cortex fine powder to obtain mixed medicinal powder; adding white spirit into the mixed medicinal powder, uniformly stirring, and sealing and placing for primary fermentation;

(3) adding the rest fine powder into the raw materials after the first fermentation, adding the Chinese liquor again, stirring uniformly, sealing and placing for the second fermentation, and then sequentially drying, crushing and subpackaging into capsule shells to obtain the Chinese herbal medicine capsule for treating rheumatoid arthritis and ankylosing spondylitis osteoarthropathy.

6. The method according to claim 5, wherein in the step (1), the pulverization is carried out to a particle size of 200-300 mesh.

7. The preparation method according to claim 5, wherein in the step (2), the mass ratio of the mixed medicinal powder to the white spirit is 10:1-3, the white spirit is 60-degree sorghum white spirit, the temperature of the first fermentation is 30-35 ℃, and the time of the first fermentation is 80-100 days.

8. The preparation method according to claim 5, wherein in the step (3), the adding amount of the white spirit accounts for 4-5% of the total mass of the raw materials and the rest raw materials after the first fermentation, the white spirit is 52-54 ° sorghum white spirit, the temperature of the second fermentation is 30-35 ℃, and the time of the second fermentation is 48-72 h.

9. The method according to claim 5, wherein in the step (3), the drying is microwave heating drying, the power of the microwave heating drying is 1-2kw, and the drying is performed for 15-25 min.

10. The method as claimed in claim 5, wherein in the step (3), the pulverization is carried out to a particle size of 300-500 mesh.