CN112120227A - Capsule for enhancing memory of children and preparation method thereof - Google Patents
Capsule for enhancing memory of children and preparation method thereof Download PDFInfo
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- CN112120227A CN112120227A CN201910556554.2A CN201910556554A CN112120227A CN 112120227 A CN112120227 A CN 112120227A CN 201910556554 A CN201910556554 A CN 201910556554A CN 112120227 A CN112120227 A CN 112120227A
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- 239000002775 capsule Substances 0.000 title claims abstract description 123
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 230000002708 enhancing effect Effects 0.000 title claims abstract description 23
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 44
- 238000001035 drying Methods 0.000 claims abstract description 26
- 241000195493 Cryptophyta Species 0.000 claims abstract description 25
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 22
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 22
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 22
- 229940046009 vitamin E Drugs 0.000 claims abstract description 22
- 239000011709 vitamin E Substances 0.000 claims abstract description 22
- 239000002994 raw material Substances 0.000 claims abstract description 20
- 238000007493 shaping process Methods 0.000 claims abstract description 14
- 238000004806 packaging method and process Methods 0.000 claims abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 45
- 108010010803 Gelatin Proteins 0.000 claims description 20
- 239000008273 gelatin Substances 0.000 claims description 20
- 229920000159 gelatin Polymers 0.000 claims description 20
- 235000019322 gelatine Nutrition 0.000 claims description 20
- 235000011852 gelatine desserts Nutrition 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 19
- 239000007901 soft capsule Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 238000004378 air conditioning Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- 238000004945 emulsification Methods 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- 239000002552 dosage form Substances 0.000 claims description 4
- 239000000499 gel Substances 0.000 claims description 2
- 238000003825 pressing Methods 0.000 claims 2
- 239000006187 pill Substances 0.000 claims 1
- 230000006866 deterioration Effects 0.000 abstract description 2
- 230000001590 oxidative effect Effects 0.000 abstract description 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 32
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 31
- 238000013461 design Methods 0.000 description 12
- 238000000746 purification Methods 0.000 description 7
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 102000004196 processed proteins & peptides Human genes 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 239000007902 hard capsule Substances 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 210000001525 retina Anatomy 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 210000003710 cerebral cortex Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000011162 core material Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- 230000008773 effect on children Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000006993 memory improvement Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention relates to a capsule for enhancing memory of children and a preparation method thereof, the capsule comprises a capsule shell and a capsule content sealed in the capsule shell, and the capsule content comprises the following components in parts by weight: 30-50 parts of DHA algae oil and 20-80 parts of natural vitamin E; the capsule is prepared by carrying out sol, batching, pelleting, shaping, drying, selecting and packaging on raw material components; the capsule is used for improving memory of children. Compared with the prior art, the invention has the advantages of stable product quality, difficult DHA oxidative deterioration, high product bioavailability, simple preparation process, convenient operation, low cost and the like.
Description
Technical Field
The invention relates to the technical field of medical health-care food, in particular to a capsule for enhancing memory of children and a preparation method thereof.
Background
DHA and docosahexaenoic acid, commonly known as NAOHUANGJIN, are unsaturated fatty acids which are very important to human body and belong to important members of omega-3 unsaturated fatty acid family. DHA is a main component for the growth and maintenance of nervous system cells, is an important constituent of brain and retina, has a content of up to 20% in human cerebral cortex and a maximum proportion of 50% in eye retina, and is therefore important for the development of intelligence and vision of infants. However, if the DHA is not stored in a good way, the DHA is easily oxidized, the oxidized DHA molecules can be damaged, most of the existing products for enhancing the memory of children at home and abroad mainly use hard capsule preparations and tablets, so that the DHA in the preparation process or the products is easily contacted with air and sunlight, the product quality is unstable, the content degradation is fast, and the shelf life is shorter. Chinese patent CN107518436A discloses a DHA oil microcapsule powder containing protein polypeptide and a preparation method thereof, wherein the microcapsule powder comprises the following components by weight percent: 20.3-41.2% of protein polypeptide, 8.8-29.7% of protein, 8.8-28.8% of carbohydrate, 20-40% of DHA algae oil, 1% of emulsifier and 0.2% of antioxidant. The preparation method comprises the steps of obtaining a mixed wall material of protein and polypeptide by properly controlling the hydrolysis degree of protein, emulsifying and mixing the wall material, a core material, an emulsifier and an antioxidant, homogenizing under high pressure, and finally spray drying to obtain the polypeptide. However, the hard capsule formulation adopted in the patent technology has unstable product quality, and the raw and auxiliary materials are extremely harsh on storage conditions and are not beneficial to production.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a capsule for enhancing the memory of children and a preparation method and application thereof.
The purpose of the invention can be realized by the following technical scheme:
a capsule for enhancing memory of children comprises a capsule shell and capsule contents enclosed in the capsule shell, wherein the capsule contents comprise the following raw materials in parts by weight: 30-50 parts of DHA algae oil and 20-80 parts of natural vitamin E.
Preferably, the raw materials of the capsule content comprise the following components in parts by weight: 40 parts of DHA algae oil and 30 parts of natural vitamin E.
The dosage form of the capsule is soft capsule.
The capsule shell comprises the following raw materials in parts by weight: 30-45 parts of gelatin, 10-40 parts of glycerol and 30-45 parts of water.
The capsule for enhancing the memory of children is prepared by carrying out sol, material preparation, pelleting, shaping, drying, sorting and packaging on the raw material components.
The preparation method of the capsule for enhancing the memory of children specifically comprises the following steps:
preparing a capsule shell: preparing materials by 30-45 parts of gelatin, 10-40 parts of glycerol and 30-45 parts of water, pouring the glycerol and the water into a full-automatic temperature-control sol-gel tank, controlling the temperature to be not more than 80 ℃, adding the gelatin, and stirring to completely dissolve the gelatin to obtain a capsule shell;
preparing capsule content: preparing materials according to the ratio of 30-50 parts of DHA algae oil to 20-80 parts of natural vitamin E, placing the DHA algae oil and the natural vitamin E in a super-emulsification homogeneous mixing tank, stirring to uniformly mix the materials, and vacuumizing for 20-30 minutes to remove bubbles, wherein the pressure is controlled to be 0.01-0.03 Mpa in the process;
preparing capsules: and pelleting, shaping, drying, selecting and packaging the prepared capsule skin and capsule content to obtain the product.
The equipment adopted during pelleting is a rotary full-automatic soft capsule making machine, the rotating speed of the rotary full-automatic soft capsule making machine is 2.5-4 r/min, the temperature of a pelleting injector is 45-50 ℃, and the thickness of capsule skin is 0.75-0.80 mm.
The equipment that adopts during the design is constant temperature and humidity design rotating cage, and the design condition is: the setting temperature is 18-26 ℃, the relative humidity is 40-50%, and the setting time is 2-4 hours.
The conditions during the drying are as follows: the drying temperature is 20-35 ℃, the relative humidity is 15-35%, the drying time is 10-14 hours, and the water content of the capsule skin is controlled to be 9-12%.
The preparation process of the capsule is carried out in a clean room manufactured by a three-stage purification air-conditioning system.
Compared with the prior art, the invention has the following advantages:
(1) DHA algae oil is used as a main raw material, and a natural antioxidant vitamin E is added, so that oxidative deterioration of DHA is avoided, and the stability of DHA is improved;
(2) the dosage form is selected from soft capsules, and the DHA algae oil is sealed in the capsules through capsule shells, so that air and illumination are avoided, the quality stability of the DHA algae oil soft capsules can be greatly improved, and the memory improvement effect on children is better;
(3) the dosage form is soft capsule, thus improving the bioavailability of the product and being beneficial to the absorption of the effective components in the capsule by human body, thereby improving the drug effect;
(4) the preparation process is simple, the operation is convenient, the cost is low, the product quality is easy to control from raw materials to finished products, the whole preparation process is finished in a certain clean area, the cleanness of the working environment is ensured, and the influence of the environment on the capsules is reduced to the maximum extent.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications can be made by persons skilled in the art without departing from the spirit of the invention. All falling within the scope of the present invention.
Example 1
A capsule for enhancing memory of children comprises a capsule shell and a capsule content sealed in the capsule shell, wherein the capsule content comprises the following raw materials in parts by weight: 30 parts of DHA algae oil and 20 parts of natural vitamin E; the capsule shell comprises the following raw materials in parts by weight: 30 parts of gelatin, 10 parts of glycerol and 30 parts of water, wherein the capsule in the embodiment is a soft capsule, and the capsule is prepared by carrying out sol, mixing, pelleting, shaping, drying, selecting and packaging on the raw material components.
The preparation method of the capsule for enhancing the memory of children in the embodiment specifically comprises the following steps:
(1) preparing a capsule shell: preparing materials according to the proportion of 30 parts of gelatin, 10 parts of glycerol and 30 parts of water, pouring the glycerol and the water into a full-automatic temperature control sol-dissolving tank, controlling the temperature to be not more than 80 ℃, adding the gelatin, and stirring to completely dissolve the gelatin to obtain a capsule shell;
(2) preparing capsule content: preparing materials according to the proportion of 30 parts of DHA algae oil and 20 parts of natural vitamin E, placing the DHA algae oil and the natural vitamin E in a super-emulsification homogeneous mixing tank, stirring to uniformly mix the materials, and vacuumizing for 20 minutes to remove bubbles, wherein the pressure is controlled to be 0.01Mpa in the process;
(3) preparing capsules: pelleting, shaping, drying, selecting and packaging the prepared capsule skin and capsule content to obtain a product; the equipment adopted during pelleting is a rotary full-automatic soft capsule making machine, the rotating speed of the rotary full-automatic soft capsule making machine is 2.5 revolutions per minute, the temperature of a pelleting injector is 45 ℃, and the thickness of capsule skin is 0.75 mm; the equipment that adopts during the design is constant temperature and humidity design rotating cage, and the design condition is: setting temperature is 18 ℃, relative humidity is 40%, and setting time is 2 hours; the conditions at the time of drying were: the drying temperature is 20 ℃, the relative humidity is 15%, the drying time is 10 hours, and the water content of the capsule skin is controlled at 9%.
The preparation process of the capsule is carried out in a clean room manufactured by a three-stage purification air-conditioning system.
The whole preparation process is carried out in a clean room manufactured by a three-stage purification air-conditioning system, so that the cleanness of the working environment is ensured, and the influence of the environment on the capsule is reduced to the maximum extent.
The capsule for enhancing memory of children is used for enhancing memory of children.
Example 2
A capsule for enhancing memory of children comprises a capsule shell and a capsule content sealed in the capsule shell, wherein the capsule content comprises the following raw materials in parts by weight: 50 parts of DHA algae oil and 80 parts of natural vitamin E; the capsule shell comprises the following raw materials in parts by weight: 45 parts of gelatin, 40 parts of glycerol and 45 parts of water, wherein the capsule in the embodiment is a soft capsule, and the capsule is prepared by carrying out sol, mixing, pelleting, shaping, drying, sorting and packaging on the raw material components.
The preparation method of the capsule for enhancing the memory of children in the embodiment specifically comprises the following steps:
(1) preparing a capsule shell: preparing materials according to the proportion of 45 parts of gelatin, 40 parts of glycerol and 45 parts of water, pouring the glycerol and the water into a full-automatic temperature control sol-dissolving tank, controlling the temperature to be not more than 80 ℃, adding the gelatin, and stirring to completely dissolve the gelatin to obtain a capsule shell;
(2) preparing capsule content: preparing materials according to the proportion of 50 parts of DHA algae oil and 80 parts of natural vitamin E, placing the DHA algae oil and the natural vitamin E in a super-emulsification homogeneous mixing tank, stirring to uniformly mix the materials, and vacuumizing for 20-30 minutes to remove bubbles, wherein the pressure is controlled to be 00.03Mpa in the process;
(3) preparing capsules: pelleting, shaping, drying, selecting and packaging the prepared capsule skin and capsule content to obtain a product; the equipment adopted during pelleting is a rotary full-automatic soft capsule making machine, the rotating speed of the rotary full-automatic soft capsule making machine is 4 r/min, the temperature of a pelleting injector is 50 ℃, and the thickness of capsule skin is 0.80 mm; the equipment that adopts during the design is constant temperature and humidity design rotating cage, and the design condition is: setting temperature is 26 ℃, relative humidity is 50%, and setting time is 4 hours; the conditions at the time of drying were: the drying temperature is 35 ℃, the relative humidity is 15%, the drying time is 10 hours, and the water content of the capsule skin is controlled at 12%.
The preparation process of the capsule is carried out in a clean room manufactured by a three-stage purification air-conditioning system.
The whole preparation process is carried out in a clean room manufactured by a three-stage purification air-conditioning system, so that the cleanness of the working environment is ensured, and the influence of the environment on the capsule is reduced to the maximum extent.
Example 3
A capsule for enhancing memory of children comprises a capsule shell and a capsule content sealed in the capsule shell, wherein the capsule content comprises the following raw materials in parts by weight: 40 parts of DHA algae oil and 60 parts of natural vitamin E; the capsule shell comprises the following raw materials in parts by weight: 35 parts of gelatin, 30 parts of glycerol and 40 parts of water, wherein the capsule in the embodiment is a soft capsule, and the capsule is prepared by carrying out sol, mixing, pelleting, shaping, drying, sorting and packaging on the raw material components.
The preparation method of the capsule for enhancing the memory of children in the embodiment specifically comprises the following steps:
(1) preparing a capsule shell: preparing materials according to the proportion of 35 parts of gelatin, 30 parts of glycerol and 40 parts of water, pouring the glycerol and the water into a full-automatic temperature control sol-dissolving tank, controlling the temperature to be not more than 80 ℃, adding the gelatin, and stirring to completely dissolve the gelatin to obtain a capsule shell;
(2) preparing capsule content: preparing materials according to the ratio of 40 parts of DHA algae oil to 60 parts of natural vitamin E, placing the DHA algae oil and the natural vitamin E in a super-emulsification homogeneous mixing tank, stirring to uniformly mix the materials, and vacuumizing for 25 minutes to remove bubbles, wherein the pressure is controlled to be 0.01Mpa in the process;
(3) preparing capsules: pelleting, shaping, drying, selecting and packaging the prepared capsule skin and capsule content to obtain a product; the equipment adopted during pelleting is a rotary full-automatic soft capsule making machine, the rotating speed of the rotary full-automatic soft capsule making machine is 2.5 revolutions per minute, the temperature of a pelleting injector is 50 ℃, and the thickness of capsule skin is 0.80 mm; the equipment that adopts during the design is constant temperature and humidity design rotating cage, and the design condition is: setting temperature is 26 ℃, relative humidity is 50%, and setting time is 4 hours; the conditions at the time of drying were: the drying temperature is 35 ℃, the relative humidity is 15%, the drying time is 14 hours, and the water content of the capsule skin is controlled at 12%.
The preparation process of the capsule is carried out in a clean room manufactured by a three-stage purification air-conditioning system.
The whole preparation process is carried out in a clean room manufactured by a three-stage purification air-conditioning system, so that the cleanness of the working environment is ensured, and the influence of the environment on the capsule is reduced to the maximum extent.
In order to prove the quality stability of the capsule for enhancing the memory of children, the shelf life of the capsule is tested in the embodiment, the initial content of the DHA algae oil and the natural vitamin E is measured when the preparation of the product is completed, and then the content of the DHA algae oil and the natural vitamin E is measured after the storage for 2 months, 4 months and 6 months, and the specific data are shown in table 1. Relative content ═ (current DHA algal oil or natural vitamin E content/initial content) × 100%.
TABLE 1 change with time of effective ingredient content in examples 1 to 3
As can be seen from Table 1, the DHA algae oil in the capsule of the present invention has good stability, and is not easy to deteriorate, thereby having better drug effect.
The foregoing description of specific embodiments of the present invention has been presented. It is to be understood that the present invention is not limited to the specific embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the appended claims without departing from the spirit of the invention.
Claims (10)
1. The capsule for enhancing the memory of the children comprises a capsule shell and a capsule content sealed in the capsule shell, and is characterized in that the capsule content comprises the following raw materials in parts by weight: 30-50 parts of DHA algae oil and 20-80 parts of natural vitamin E.
2. The capsule for enhancing memory of children according to claim 1, wherein the raw materials of the capsule content comprise the following components in parts by weight: 40 parts of DHA algae oil and 60 parts of natural vitamin E.
3. The capsule for improving memory of children as claimed in claim 1, wherein the dosage form of the capsule is soft capsule.
4. The capsule for enhancing memory of children as claimed in claim 1, wherein the capsule shell comprises the following raw materials in parts by weight: 30-45 parts of gelatin, 10-40 parts of glycerol and 30-45 parts of water.
5. The method for preparing a capsule for improving memory of children according to claim 1, wherein the capsule is prepared by the steps of dissolving raw materials in a sol, blending, pelleting, shaping, drying, sorting and packaging.
6. The method for preparing the capsule for enhancing the memory of children according to claim 5, comprising the following steps:
preparing a capsule shell: preparing materials by 30-45 parts of gelatin, 10-40 parts of glycerol and 30-45 parts of water, pouring the glycerol and the water into a full-automatic temperature-control sol-gel tank, controlling the temperature to be not more than 80 ℃, adding the gelatin, and stirring to completely dissolve the gelatin to obtain a capsule shell;
preparing capsule content: preparing materials according to the proportion of 30-50 parts of DHA algae oil and 20-80 parts of natural vitamin E, placing the DHA algae oil and the natural vitamin E in a super-emulsification homogeneous mixing tank, stirring to uniformly mix the materials, and vacuumizing for 20-30 minutes to remove bubbles, wherein the pressure is controlled to be 0.01-0.03 Mpa in the process;
preparing capsules: and pelleting, shaping, drying, selecting and packaging the prepared capsule skin and capsule content to obtain the product.
7. The method for preparing capsule for improving memory of children according to claim 5, wherein the equipment used for pressing is a rotary full-automatic soft capsule making machine, the rotary full-automatic soft capsule making machine rotates at 2.5-4 r/min, the temperature of a pressing pill injector is 45-50 ℃, and the thickness of capsule skin is 0.75-0.80 mm.
8. The preparation method of the capsule for enhancing memory of children as claimed in claim 5, wherein the device used for shaping is a constant temperature and humidity shaping rotating cage, and the shaping conditions are as follows: the setting temperature is 18-26 ℃, the relative humidity is 40-50%, and the setting time is 2-4 hours.
9. The method for preparing a capsule for improving memory of children according to claim 5, wherein the drying condition is: the drying temperature is 20-35 ℃, the relative humidity is 15-35%, the drying time is 10-14 hours, and the water content of the capsule skin is controlled to be 9-12%.
10. The method for preparing a capsule for improving memory of children as claimed in claim 5, wherein the capsule is prepared in a clean room made by a three-stage clean air conditioning system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910556554.2A CN112120227A (en) | 2019-06-25 | 2019-06-25 | Capsule for enhancing memory of children and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201910556554.2A CN112120227A (en) | 2019-06-25 | 2019-06-25 | Capsule for enhancing memory of children and preparation method thereof |
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| CN112120227A true CN112120227A (en) | 2020-12-25 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114521653A (en) * | 2022-02-18 | 2022-05-24 | 海南丰瑞实业投资有限公司 | Formula and preparation process of pomelo oil soft capsule |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114521653A (en) * | 2022-02-18 | 2022-05-24 | 海南丰瑞实业投资有限公司 | Formula and preparation process of pomelo oil soft capsule |
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Application publication date: 20201225 |