CN112119099A - 三特异性抗原结合蛋白 - Google Patents

三特异性抗原结合蛋白 Download PDF

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Publication number
CN112119099A
CN112119099A CN201980016065.6A CN201980016065A CN112119099A CN 112119099 A CN112119099 A CN 112119099A CN 201980016065 A CN201980016065 A CN 201980016065A CN 112119099 A CN112119099 A CN 112119099A
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binding
protein
cell
antigen
trispecific antigen
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莱昂纳多·博拉斯
多米尼克·埃舍尔
克里斯蒂安·瓦尔德马·温格·莱斯纳
法比安·沙伊费勒
托马斯·施莱尔
菲利普·罗伯特·瑞克雷
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Cdr Biotechnology Co ltd
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Cdr Biotechnology Co ltd
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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CN201980016065.6A 2018-03-02 2019-03-01 三特异性抗原结合蛋白 Pending CN112119099A (zh)

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US201862637470P 2018-03-02 2018-03-02
US62/637,470 2018-03-02
PCT/EP2019/055207 WO2019166650A1 (en) 2018-03-02 2019-03-01 Trispecific antigen binding proteins

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US (2) US20200062858A1 (https=)
EP (1) EP3759146A1 (https=)
JP (1) JP2021515806A (https=)
KR (1) KR20210028140A (https=)
CN (1) CN112119099A (https=)
AU (1) AU2019228128A1 (https=)
CA (1) CA3089230A1 (https=)
MX (1) MX2020009116A (https=)
WO (1) WO2019166650A1 (https=)

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US10815311B2 (en) 2018-09-25 2020-10-27 Harpoon Therapeutics, Inc. DLL3 binding proteins and methods of use
EP3816185A1 (en) * 2019-11-04 2021-05-05 Numab Therapeutics AG Multispecific antibody directed against pd-l1 and a tumor-associated antigen
JP2023501942A (ja) * 2019-11-08 2023-01-20 ナノテンパー・テクノロジーズ・ゲーエムベーハー 溶液中の粒子の特徴付け
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WO2022087211A1 (en) * 2020-10-22 2022-04-28 Janux Therapeutics, Inc. Antibodies targeting her2 and cd3 and uses thereof
AU2022286960A1 (en) * 2021-06-03 2024-01-18 Harpoon Therapeutics, Inc. Bcma targeting trispecific proteins and methods of use
KR20240067088A (ko) * 2021-09-16 2024-05-16 지티 바이오파마, 인크. 융합 단백질을 표적으로 하는 pd-l1 및 이의 사용 방법
CN114371282B (zh) * 2021-12-30 2025-07-11 上海药明生物技术有限公司 一种评估抗原沉默效应对抗体药效影响的方法及其应用
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CN114853897A (zh) * 2021-04-15 2022-08-05 北京大学深圳研究生院 抗cd19/cd22/cd3三特异性抗体及用途
CN114853897B (zh) * 2021-04-15 2024-01-26 北京大学深圳研究生院 抗cd19/cd22/cd3三特异性抗体及用途
WO2025026282A1 (en) * 2023-07-29 2025-02-06 Shanghai Kaijin Biotechnology, Ltd Modified type e multi-specific antibodies

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MX2020009116A (es) 2020-12-07
CA3089230A1 (en) 2019-09-06
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US20200024358A1 (en) 2020-01-23

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