CN112114100A - Automatic drug testing system and method by flow cell method - Google Patents
Automatic drug testing system and method by flow cell method Download PDFInfo
- Publication number
- CN112114100A CN112114100A CN202010907794.5A CN202010907794A CN112114100A CN 112114100 A CN112114100 A CN 112114100A CN 202010907794 A CN202010907794 A CN 202010907794A CN 112114100 A CN112114100 A CN 112114100A
- Authority
- CN
- China
- Prior art keywords
- solvent
- flow cell
- block
- heating
- sampling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Hydrology & Water Resources (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
A flow cell method drug automatic test system and test method, including drug circulation system, solution medium heating system, sampling system; the medicine circulation system comprises a frame, a frame cover, a support frame, a dry heating block, a heating guide sleeve, a circulation pool and a circulation pump; the solvent heating system comprises a heating box, a heating wire, a dissolving cup holder and a solvent cup; the sampling system comprises a sampling mechanism, a sampling valve and a sampling pump; the inlet of the flow cell is communicated with the outlet of the solvent cup through a pipeline, the inlet pipeline of the flow cell is communicated with a circulating pump, and the outlet of the flow cell is communicated with the inlet of the solvent cup through a pipeline; the inlet of the sampling mechanism is communicated with the sampling port of the solvent cup through a pipeline. The support frame realizes the switching arrangement of the longitudinal and transverse forms of the flow cell; when the flow cell is vertically arranged, the device is suitable for the traditional tablet and capsule scouring dissolution release, and when the flow cell is horizontally arranged, the device is suitable for the osmotic dissolution release of preparations such as microspheres, suppositories, suspensions and the like.
Description
Technical Field
The invention relates to the technical field of medical experimental equipment application, in particular to a flow cell method drug automatic testing system and a testing method.
Background
With the rapid development of pharmaceutical technology and the emergence of a large number of novel medicaments and the current requirement on the In Vivo and In Vitro Correlation (IVIVC) of a dissolution rate measurement method, the traditional dissolution rate measurement method (paddle method, basket method and the like) has new problems in the aspect of measurement of preparation quality, such as the measurement of trace amount of medicinal preparations, the formulation of novel medicaments such as patches, microspheres and the like, and how to solve the in vivo and in vitro correlation of quick-release preparations. As a novel dissolution concentration checking method, the flow cell method mainly depends on flowing solvent to continuously flush the preparation, can well simulate the in vivo circulation of the medicine in a human body, and selects proper cell body accessories to be suitable for tablets, capsules, patches, microspheres, suppositories, suspensions, stents, implants, liposomes and the like.
The flow cell method can be used for measuring the dissolution rate of traditional tablets and capsules and can also be applied to the dissolution rate measurement of different types of preparations such as suspensions, implants, microsphere liposomes and the like, but the process usually needs to use flow cell structures with different structural forms, and for the dissolution and release of the tablets and the capsules, a solvent has higher dissolution and flow rate and is not suitable for the dissolution and release concentration measurement of the preparations such as the microspheres, the suppositories, the suspensions and the like. There is a need for a flow cell method for a universal test system for a variety of formulations.
Disclosure of Invention
In order to solve the existing problems, the invention discloses a flow cell method drug automatic test system and a test method, and the specific technical scheme is as follows: a flow cell method drug automatic test system comprises a drug flow system, a solvent heating system and a sampling system;
the drug circulation system is used for introducing a solvent into the drug circulation system for flow release; comprises a frame, a frame cover, a supporting frame, a dry heating block, a heating guide sleeve, a flow cell and a circulating pump; the rack cover is arranged on the side surface of the rack; the supporting frame is arranged on the top surface of the rack, and the supporting frame and the rack are arranged in a rotatable manner; the dry heating block is fixed on the inner side of the support frame; the heating guide sleeve is arranged in the dry heating block; each flow cell is respectively inserted into the heating jacket;
the solvent heating system is used for receiving and storing the solvent released by the drug circulation system and carrying out constant temperature treatment on the solvent; comprises a heating box, a heating wire, a dissolving cup rack and a solvent cup; the heating wire is arranged in the heating box; the dissolving cup frame is fixedly arranged at the top end of the heating box, and the solvent cup is fixedly inserted into the dissolving cup frame;
the sampling system is used for sampling the menstruum released by the medicine circulation system; comprises a sampling mechanism, a sampling valve and a sampling pump;
the inlet of the flow cell is communicated with the outlet of the solvent cup through a pipeline, the inlet pipeline of the flow cell is communicated with a circulating pump, and the outlet of the flow cell is communicated with the inlet of the solvent cup through a pipeline; the inlet of the sampling mechanism is communicated with the sampling port of the solvent cup through a pipeline, and the inlet pipeline of the sampling mechanism is connected with a sampling valve.
Furthermore, a solvent inlet pipe is arranged on the bottom surface of one side of the frame, corresponds to the bottom end of each flow cell, and is connected with a pipeline in an inserting mode through a connector; and a solvent outlet pipe is arranged on one side of the top end of the frame, corresponds to the top end of each flow cell, and is inserted and connected through a plug to realize pipeline communication.
Furthermore, a stepping motor is embedded in the bottom surface of one side of the rack, each stepping motor is correspondingly arranged at the bottom end of each flow cell, a rotating disc is arranged at the end part of each stepping motor, the rotating discs and the stepping motors coaxially rotate, magnetic poles are arranged on two sides of the top surface of each rotating disc, and the magnetic poles and the rotating discs are fixedly arranged; the top surface of rotary disk is equipped with the shade, the shade with the bottom surface of frame passes through the bolt fastening.
Furthermore, the number of the dry heating blocks is eight, and the dry heating blocks are arranged in a transverse array; the number of the heating guide sleeves is eight; the number of the flow-through cells is eight; the number of the solvent inlet pipes is eight; the number of the solvent outlet pipes is eight; the number of the stepping motors is eight; the number of the solvent cups is eight.
Furthermore, the supporting frame comprises fixed seats and a movable frame, the fixed seats are arranged on two sides of the top surface of the rack, and the fixed seats on each side are perpendicular to the rack through bolts; the adjustable shelf sets up in both sides between the fixing base, adjustable shelf both sides bottom respectively through the pivot with the fixing base realizes rotating.
Furthermore, the top surface of the support frame is also provided with a pressing mechanism, and the pressing mechanism comprises an edge plate, a central block, a rotating plate, a threaded cylinder, a star-shaped handle and a pressing block; the edge plates are arranged on two sides of the top end of the movable frame and are fixedly arranged with the movable frame through bolts respectively; the center block is fixedly arranged at the center of the top side of the movable frame, the section of the center block is of an I-shaped structure, and center block clamping grooves are formed in two sides of the center block; the rotating plates are arranged on the top sides of the movable frames, one corner of each rotating plate and one corner of each edge plate are rotatably arranged through bolts, and the edge plates are rotatably embedded into the clamping grooves of the central block; the threaded cylinder is arranged at the bottom end of the rotating plate and is fixedly arranged with the rotating plate, and the threaded cylinder penetrates through the rotating plate; the star-shaped handle penetrates through the threaded cylinder and is in threaded connection with the threaded cylinder, and the bottom end of the star-shaped handle extends out of the bottom end of the rotating plate; the briquetting fixed set up in the bottom of star handle.
Furthermore, one side of the dry heating block is provided with an upright mortise lock mechanism, and the upright mortise lock mechanism comprises a mortise lock block, a mortise lock rod, a mortise lock handle, an upper limit block, a lower limit block and a spring; the latch block is vertically assembled with one dry heating block through a bolt; the locking latch rod penetrates through the locking latch block, is vertically arranged and can be arranged with the locking latch block in a sliding manner; the mortise lock handle is arranged on one side of the top end of the mortise lock rod; the upper limiting block is fixedly arranged on the outer wall of the top end of the insertion locking rod; the lower limiting block is arranged on the outer wall of the bottom end of the insertion locking rod; the spring is sleeved on the outer wall of the latch rod, the top end of the spring abuts against the bottom surface of the latch block, and the bottom end of the spring abuts against the top surface of the lower limiting block; the bottom surface one side of frame still is equipped with the locking piece, the locking piece pass through the bolt with frame fixed assembly, the top surface of locking piece is equipped with the locking hole, the mortise lock pole cuttage in the locking hole realizes upright mortise lock mechanism is fixed with the frame.
Further, when the frame is in a longitudinally-arranged state, the upper part of the flow cell is sequentially provided with filter layers from bottom to top, and the filter layers are multi-layered.
Further, the medicine circulation system is still including the control box, the control box passes through the connection of electric lines with step motor, dry heating piece, circulating pump, heater strip, sample valve and sample pump respectively, realizes signal transmission, the control box is the PLC controller, and the switch through programming software control step motor, circulating pump and sample pump starts, controls the switching on-off state of sample valve, controls the heating temperature who heats piece and heater strip futilely.
A test method of a flow cell method drug automatic test system comprises the following steps:
1. placing dissolved medicine (such as tablet and capsule) into a flow cell, placing a magnetic stirrer into the flow cell, and sleeving a heating guide sleeve on the outer wall of the flow cell; the flow cell and the heating guide sleeve are inserted into the dry heating block together;
2. rotating the support frame, relatively rotating the movable frame and the fixed seat to enable the movable frame to be in a vertical state, adjusting the vertical mortise lock mechanism, lifting the mortise lock handle by hand to lift the mortise lock rod upwards, enabling the lower limit block to be abutted to the spring to be in a yield state, aligning the bottom end of the mortise lock rod with the locking hole, restoring the spring to deform after the mortise lock handle is loosened, pushing the mortise lock rod to be inserted into the locking hole, attaching the bottom surface of the upper limit block to the top surface of the mortise lock block, and enabling the support frame to be vertically locked with the rack through the vertical mortise lock mechanism;
3. the adjusting pressing mechanism rotates the rotating plate and is embedded into the clamping groove of the central block for fixing, the star-shaped handle is rotationally adjusted to be matched with the threaded cylinder, the star-shaped handle drives the pressing block to press and abut against the top end of the flow cell, and the pressing mechanism abuts against and fixes the flow cell and the dry heating block;
4. the bottom end of the flow cell is spliced and communicated with a solvent inlet pipe, and the top end of the flow cell is spliced and communicated with a solvent outlet pipe;
5. starting a heating wire, heating a water area in a heating box to realize that the temperature of a solvent in a solvent cup is controlled at 37 ℃;
6. starting the circulating pump, enabling the circulating pump to enable the solvent in the solvent cup to enter the circulating pool through the solvent inlet pipe under the circulating action of the circulating pump, and discharging the dissolved solvent and the dissolved medicine into the solvent cup through the solvent outlet pipe;
7. starting a stepping motor, driving a rotating disk to rotate by the stepping motor, driving a magnetic pole to rotate along with the rotating disk, driving a magnetic stirrer in a flow cell to rotate by the magnetic pole, and intensifying the disturbance degree of a solvent flowing through the flow cell;
8. and starting the sampling pump and the sampling valve, and pumping the solvent in the solvent cup into the sampling mechanism by the sampling pump to realize the sampling process. The invention has the beneficial effects that:
according to the invention, the support frame structure is arranged in the medicine circulation system, the circulation pool and the support frame structure are fixedly inserted, and the support frame realizes the switching arrangement of the longitudinal and transverse forms of the circulation pool; when the flow cell is matched with the support frame to be longitudinally arranged, the device meets the requirements of a flow cell method, the solvent can flow according to a set flow rate, the traditional tablets and capsules can be washed, dissolved and released, when the flow cell is changed and is matched with the support frame to be transversely arranged, the device is in an osmotic flow mode, the solvent can flow according to the set flow rate, and the preparation such as microspheres, suppositories, suspensions and the like can be dissolved and released; the device can switch the longitudinal and transverse forms of the flow cell by using the support frame, and can meet the universal dissolution sampling process of various preparations such as tablets, capsules, microspheres, suppositories, suspensions and the like.
The invention aims at the top side of the support frame structure to be provided with the pressing mechanism, the end part of the flow cell can be pressed and fixed by manually adjusting the star-shaped handle, the flow cell can be kept well positioned with the dry heating block under the condition of being longitudinally or transversely arranged, and the medicine dissolution of the flow cell is ensured to run under the stable state.
According to the invention, the vertical mortise lock mechanism is arranged on the side wall of the support frame structure, when the support frame is in a vertical state, the mortise lock rod is in contraposition insertion with the locking hole, so that the support frame can be locked and fixed in the vertical state, and the vertical mortise lock mechanism is simple in structural design and convenient to operate.
Drawings
FIG. 1 is a schematic flow diagram of the system of the present invention.
Fig. 2 is a schematic view of the overall appearance structure of the invention.
Fig. 3 is a schematic view of the overall structure of the present invention in the state of embodiment 1.
Fig. 4 is a schematic view of the internal structure of the bottom surface of the housing of the present invention.
Fig. 5 is a partial structural schematic view of the supporting frame structure of the present invention.
Fig. 6 is a schematic view of the overall structure of the present invention in the state of embodiment 1.
FIG. 7 is a schematic cross-sectional view of a flow cell with the housing of the present invention in an upright position.
List of reference numerals:
a drug flow-through system 1;
the device comprises a frame 1-1, a solvent inlet pipe 1-1, a solvent outlet pipe 1-1-2, a stepping motor 1-1-3, a rotating disk 1-1-4, magnetic poles 1-1-5, a shade 1-1-6, a locking block 1-1-7 and locking holes 1-1-7-1;
a rack cover 1-2;
1-3 parts of a support frame, 1-3-1 parts of a fixed seat and 1-3-2 parts of a movable frame;
1-4 of a dry heating block;
heating the guide sleeve 1-5;
1-6 of a flow cell;
1-6-1 of a filter screen;
1-7 parts of a circulating pump;
1-7 parts of a pressing mechanism, 1-7-1 parts of edge plates, 1-7-2 parts of a central block, 1-7-2-1 parts of a central block clamping groove, 1-7-3 parts of a rotating plate, 1-7-4 parts of a threaded cylinder, 1-7-5 parts of a star-shaped handle and 1-7-6 parts of a pressing block;
the vertical mortise lock comprises, by weight, 1-8 parts of a vertical mortise lock mechanism, 1-8-1 parts of a mortise lock block, 1-8-2 parts of a mortise lock rod, 1-8-3 parts of a mortise lock handle, 1-8-4 parts of an upper limit block, 1-8-5 parts of a lower limit block and 1-8-6 parts of a spring;
1-9 of a control box;
a solvent heating system 2;
2-1 of a heating box;
2-2 of heating wires;
2-3 parts of a cup dissolving frame;
2-4 parts of solvent cup;
a sampling system 3;
a sampling mechanism 3-1;
a sampling valve 3-2;
and a sampling pump 3-3.
Detailed Description
In order to make the technical scheme of the invention clearer and clearer, the invention is further described with reference to the accompanying drawings, and any scheme obtained by carrying out equivalent replacement and conventional reasoning on the technical characteristics of the technical scheme of the invention falls into the protection scope of the invention. The fixed connection, the fixed arrangement and the fixed structure mentioned in the embodiment are known technologies known to those skilled in the art, such as gluing, welding, screwing, bolt-nut connection, riveting and the like.
In this embodiment, when the frame is disposed longitudinally, the flow cell is a common flow cell method flow cell, the upper portion of the flow cell is sequentially provided with a plurality of filter layers from bottom to top, the number of the filter layers is four, and the aperture of the filter holes of each filter layer is sequentially 120um, 80um, 60um and 20um from bottom to top;
when the rack is in the transverse arrangement, the flow cell structure is adopted with the patent number "20192053381949", and the patent name "an absorption cell structure of a drug absorption sampling system".
Example 1
With the attached drawings, the automatic drug testing system adopting the flow cell method comprises a drug flow system 1, a solvent heating system 2 and a sampling system 3;
the drug circulation system 1 is used for introducing a solvent into the drug circulation system 1 for flow release; comprises a frame 1-1, a frame cover 1-2, a support frame 1-3, a dry heating block 1-4, a heating guide sleeve 1-5, a flow cell 1-6 and a circulating pump 1-7; the rack cover 1-2 is arranged on the side surface of the rack 1-1; the support frame 1-3 is arranged on the top surface of the rack 1-1, and the support frame 1-3 and the rack 1-1 are arranged in a rotatable manner; the dry heating blocks 1-4 are fixed on the inner sides of the support frames 1-3; the heating guide sleeve 1-5 is arranged in the dry heating block 1-4; each flow cell 1-6 is respectively inserted into the heating guide sleeve 1-5;
the solvent heating system 2 is used for receiving and storing the solvent released by the drug circulation system 1 and carrying out constant temperature treatment on the solvent; comprises a heating box 2-1, a heating wire 2-2, a dissolving cup rack 2-3 and a solvent cup 2-4; the heating wire 2-2 is arranged in the heating box 2-1; the dissolving cup frame 2-3 is fixedly arranged at the top end of the heating box 2-1, and the solvent cup 2-4 is fixedly inserted into the dissolving cup frame 2-3;
the sampling system 3 is used for sampling the menstruum released by the medicine flowing system 1; comprises a sampling mechanism 3-1, a sampling valve 3-2 and a sampling pump 3-3;
the inlet of the flow cell 1-6 is communicated with the outlet of the solvent cup 2-4 through a pipeline, the inlet pipeline of the flow cell 1-6 is communicated with a circulating pump 1-7, and the outlet of the flow cell 1-6 is communicated with the inlet of the solvent cup 2-4 through a pipeline; the inlet of the sampling mechanism 3-1 is communicated with the sampling port of the solvent cup 2-4 through a pipeline, and the inlet pipeline of the sampling mechanism 3-1 is connected with a sampling valve 3-2.
Furthermore, a solvent inlet pipe 1-1-1 is arranged on the bottom surface of one side of the frame 1-1, the solvent inlet pipe 1-1-1 corresponds to the bottom end of each flow cell 1-6, and the pipeline communication is realized through the splicing of connectors; a solvent outlet pipe 1-1-2 is arranged on one side of the top end of the frame 1-1, the solvent outlet pipe 1-1-2 corresponds to the top end of each flow cell 1-6, and pipeline communication is achieved through plug insertion.
Further, stepping motors 1-1-3 are embedded in the bottom surface of one side of the rack 1-1, each stepping motor 1-1-3 is correspondingly arranged at the bottom end of each flow cell 1-6, a rotating disc 1-1-4 is arranged at the end part of each stepping motor 1-1-3, the rotating disc 1-1-4 and the stepping motors 1-1-3 rotate coaxially, magnetic poles 1-1-5 are arranged on two sides of the top surface of the rotating disc 1-1-4, and the magnetic poles 1-1-5 and the rotating disc 1-1-4 are fixedly arranged; the top surface of the rotating disc 1-1-4 is provided with a shade 1-1-6, and the shade 1-1-6 is fixed with the bottom surface of the frame 1-1 through bolts.
Furthermore, the number of the dry heating blocks 1-4 is multiple, and the dry heating blocks are arranged in a transverse array; the number of the heating guide sleeves 1-5 is multiple; the number of the flow-through cells 1-6 is multiple; the number of the solvent inlet pipes 1-1-1 is multiple; the number of the solvent outlet pipes 1-1-2 is multiple; the number of the stepping motors 1-1-3 is multiple; the number of the solvent cups 2-4 is more than one; the dry heating blocks 1-4, the heating guide sleeves 1-5, the flow cell 1-6, the solvent inlet pipe 1-1-1, the solvent outlet pipe 1-1-2, the stepping motor 1-1-3 and the solvent cup 2-4 are consistent in number.
Further, the support frame 1-3 comprises a fixed seat 1-3-1 and a movable frame 1-3-2, the fixed seat 1-3-1 is arranged on two sides of the top surface of the rack 1-1, and the fixed seat 1-3-1 on each side is vertically arranged with the rack 1-1 through a bolt; the movable frame 1-3-2 is arranged between the fixed seats 1-3-1 at two sides, and the bottom ends at two sides of the movable frame 1-3-2 respectively rotate with the fixed seats 1-3-1 through rotating shafts.
Furthermore, the top surface of the support frame 1-3 is also provided with a pressing mechanism 1-7, and the pressing mechanism 1-7 comprises an edge plate 1-7-1, a central block 1-7-2, a rotating plate 1-7-3, a threaded cylinder 1-7-4, a star-shaped handle 1-7-5 and a pressing block 1-7-6; the edge plates 1-7-1 are arranged on two sides of the top end of the movable frame 1-3-2, and the edge plates 1-7-1 are fixedly arranged with the movable frame 1-3-2 through bolts respectively; the center block 1-7-2 is fixedly arranged at the center of the top side of the movable frame 1-3-2, the section of the center block 1-7-2 is of an I-shaped structure, and two sides of the center block 1-7-2 form a center block clamping groove 1-7-2-1; the rotating plates 1-7-3 are arranged on the top sides of the movable frames 1-3-2, one corner of each rotating plate 1-7-3 is rotatably arranged with one corner of each edge plate 1-7-1 through a bolt, and the edge plates 1-7-1 are rotatably embedded into the central block clamping grooves 1-7-2-1; the threaded cylinder 1-7-4 is arranged at the bottom end of the rotating plate 1-7-3 and is fixedly arranged with the rotating plate 1-7-3, and the threaded cylinder 1-7-4 penetrates through the rotating plate 1-7-3; the star-shaped handle 1-7-5 penetrates through the threaded cylinder 1-7-4 and is in threaded connection with the threaded cylinder 1-7-4, and the bottom end of the star-shaped handle 1-7-5 extends out of the bottom end of the rotating plate 1-7-3; the pressing block 1-7-6 is fixedly arranged at the bottom end of the star-shaped handle 1-7-5.
Furthermore, one side of the dry heating block 1-4 is provided with an upright mortise lock mechanism 1-8, and the upright mortise lock mechanism 1-8 comprises a mortise lock block 1-8-1, a mortise lock rod 1-8-2, a mortise lock handle 1-8-3, an upper limit block 1-8-4, a lower limit block 1-8-5 and a spring 1-8-6; the latch block 1-8-1 is vertically assembled with one dry heating block 1-4 through a bolt; the latch rod 1-8-2 penetrates through the latch block 1-8-1, is vertically arranged and can be slidably arranged with the latch block 1-8-1; the mortise lock handle 1-8-3 is arranged on one side of the top end of the mortise lock rod 1-8-2; the upper limiting block 1-8-4 is fixedly arranged on the outer wall of the top end of the insertion locking rod 1-8-2; the lower limiting block 1-8-5 is arranged on the outer wall of the bottom end of the insertion locking rod 1-8-2; the spring 1-8-6 is sleeved on the outer wall of the latch rod 1-8-2, the top end of the spring 1-8-6 abuts against the bottom surface of the latch block 1-8-1, and the bottom end of the spring 1-8-6 abuts against the top surface of the lower limiting block 1-8-5; the vertical mortise lock is characterized in that a locking block 1-1-7 is further arranged on one side of the bottom surface of the rack 1-1, the locking block 1-1-7 is fixedly assembled with the rack 1-1 through a bolt, a locking hole 1-1-7-1 is formed in the top surface of the locking block 1-1-7, and a mortise lock rod 1-8-2 is inserted into the locking hole 1-1-7-1, so that the vertical mortise lock is fixed to the rack 1-1 through the vertical mortise lock mechanism 1-8.
Further, when the frame is in a longitudinally-arranged state, the upper part of the flow cell is sequentially provided with filter layers from bottom to top, and the filter layers are multi-layered.
Furthermore, the medicine circulation system 1 further comprises a control box 1-9, the control box 1-9 is respectively connected with the stepping motor 1-1-3, the dry heating block 1-4, the circulating pump 1-7, the heating wire 2-2, the sampling valve 3-2 and the sampling pump 3-3 through electric wires to realize signal transmission, the control box 1-9 is a PLC controller, switches of the stepping motor 1-1-3, the circulating pump 1-7 and the sampling pump 3-3 are controlled to be started through programming software, the switching on-off state of the sampling valve 3-2 is controlled, and the heating temperature of the dry heating block 1-4 and the heating wire 2-2 is controlled.
A test method of a flow cell method drug automatic test system comprises the following steps:
1. placing dissolved medicine (such as tablet and capsule) into a flow cell 1-6, placing a magnetic stirrer into the flow cell 1-6, and sleeving a heating guide sleeve 1-5 on the outer wall of the flow cell 1-6; the flow cell 1-6 and the heating guide sleeve 1-5 are inserted into the dry heating block 1-4 together;
2. rotating the support frame 1-3, relatively rotating the movable frame 1-3-2 and the fixed seat 1-3-1 to enable the movable frame 1-3-2 to be in a vertical state, adjusting the vertical mortise lock mechanism 1-8, lifting the mortise lock handle 1-8-3 by hand to lift the mortise lock rod 1-8-2 upwards, enabling the lower limit block 1-8-5 to abut against the spring 1-8-6 to be in a yield state, aligning the bottom end of the mortise lock rod 1-8-2 with the locking hole 1-1-7-1, enabling the spring 1-8-6 to recover deformation after releasing the mortise lock handle 1-8-3, pushing the mortise lock rod 1-8-2 to be inserted into the locking hole 1-1-7-1, enabling the bottom surface of the upper limit block 1-8-4 to abut against the top surface of the mortise lock block 1-8-1, the support frame 1-3 is vertically locked with the frame 1-1 through a vertical mortise lock mechanism 1-8;
3. adjusting a pressing mechanism 1-7, rotating a rotating plate 1-7-3, embedding the rotating plate into a central block clamping groove 1-7-2-1 for fixing, rotating and adjusting a star-shaped handle 1-7-5 to be matched with a threaded cylinder 1-7-4, driving a pressing block 1-7-6 to be pressed and pressed against the top end of a flow cell 1-6 by the star-shaped handle 1-7-5, and pressing and fixing the flow cell 1-6 and a dry heating block 1-4 by the pressing mechanism 1-7;
4. the bottom end of the flow cell 1-6 is spliced and communicated with a solvent inlet pipe 1-1-1, and the top end of the flow cell 1-6 is spliced and communicated with a solvent outlet pipe 1-1-2;
5. starting the heating wire 2-2, heating the water area in the heating box 2-1 to realize the temperature control of the solvent in the solvent cup 2-4 at 37 ℃;
6. starting the circulating pump 1-7, enabling the circulating pump 1-7 to enable the solvent in the solvent cup 2-4 to enter the flow cell 1-6 through the solvent inlet pipe 1-1-1 under the circulating action of the circulating pump 1-7, and discharging the dissolved solvent and the medicine into the solvent cup 2-4 through the solvent outlet pipe 1-1-2;
7. starting a stepping motor 1-1-3, driving a rotating disk 1-1-4 to rotate by the stepping motor 1-1-3, driving a magnetic stirrer in a flow cell 1-6 to rotate by a magnetic pole 1-1-5 along with the rotating disk 1-1-4 to rotate, and driving a magnetic stirrer in the flow cell 1-6 to rotate by the magnetic pole 1-1-5 to intensify the disturbance degree of a solvent flowing through the flow cell 1-6;
8. the sampling pump 3-3 and the sampling valve 3-2 are started, and the sampling pump 3-3 pumps the solvent in the solvent cup 2-4 into the sampling mechanism 3-1 to realize the sampling process.
Example 2
a test method of a flow cell method drug automatic test system comprises the following steps:
1. placing dissolved medicine (such as microsphere, suppository, suspension) into flow cell 1-6, and sleeving heating guide sleeve 1-5 on outer wall of flow cell 1-6; the flow cell 1-6 and the heating guide sleeve 1-5 are inserted into the dry heating block 1-4 together;
2. adjusting a pressing mechanism 1-7, rotating a rotating plate 1-7-3, embedding the rotating plate into a central block clamping groove 1-7-2-1 for fixing, rotating and adjusting a star-shaped handle 1-7-5 to be matched with a threaded cylinder 1-7-4, driving a pressing block 1-7-6 to be pressed and pressed against the top end of a flow cell 1-6 by the star-shaped handle 1-7-5, and pressing and fixing the flow cell 1-6 and a dry heating block 1-4 by the pressing mechanism 1-7;
3. rotating the support frame 1-3, and relatively rotating the movable frame 1-3-2 and the fixed seat 1-3-1 to enable the movable frame 1-3-2 to be attached to the top surface of the rack 1-1 in a transverse state;
4. the bottom end of the flow cell 1-6 is spliced and communicated with a solvent inlet pipe 1-1-1, and the top end of the flow cell 1-6 is spliced and communicated with a solvent outlet pipe 1-1-2;
5. starting the heating wire 2-2, heating the water area in the heating box 2-1 to realize the temperature control of the solvent in the solvent cup 2-4 at 37 ℃;
6. starting the circulating pump 1-7, enabling the circulating pump 1-7 to enable the solvent in the solvent cup 2-4 to enter the flow cell 1-6 through the solvent inlet pipe 1-1-1 under the circulating action of the circulating pump 1-7, and discharging the dissolved solvent and the medicine into the solvent cup 2-4 through the solvent outlet pipe 1-1-2;
7. the sampling pump 3-3 and the sampling valve 3-2 are started, and the sampling pump 3-3 pumps the solvent in the solvent cup 2-4 into the sampling mechanism 3-1 to realize the sampling process.
The invention has the beneficial effects that:
according to the invention, the support frame structure is arranged in the medicine circulation system, the circulation pool and the support frame structure are fixedly inserted, and the support frame realizes the switching arrangement of the longitudinal and transverse forms of the circulation pool; when the flow cell is matched with the support frame to be longitudinally arranged, the device meets the requirements of a flow cell method, the solvent is at a high flow rate, the traditional tablets and capsules can be washed, dissolved and released, when the flow cell is changed and the support frame is matched to be transversely arranged, the device is in an osmotic flow mode, the solvent is at a low flow rate, and the preparation such as microspheres, suppositories, suspensions and the like can be dissolved and released; the device can switch the longitudinal and transverse forms of the flow cell by using the support frame, and can meet the universal dissolution sampling process of various preparations such as tablets, capsules, microspheres, suppositories, suspensions and the like.
The invention aims at the top side of the support frame structure to be provided with the pressing mechanism, the end part of the flow cell can be pressed and fixed by manually adjusting the star-shaped handle, the flow cell can be kept well positioned with the dry heating block under the condition of being longitudinally or transversely arranged, and the medicine dissolution of the flow cell is ensured to run under the stable state.
According to the invention, the vertical mortise lock mechanism is arranged on the side wall of the support frame structure, when the support frame is in a vertical state, the mortise lock rod is in contraposition insertion with the locking hole, so that the support frame can be locked and fixed in the vertical state, and the vertical mortise lock mechanism is simple in structural design and convenient to operate.
Claims (10)
1. A flow cell method drug automatic test system is characterized by comprising a drug flow system (1), a solvent heating system (2) and a sampling system (3);
the drug circulation system (1) is used for introducing a solvent into the drug circulation system (1) for flow release; comprises a frame (1-1), a frame cover (1-2), a support frame (1-3), a dry heating block (1-4), a heating guide sleeve (1-5), a flow cell (1-6) and a circulating pump (1-7); the rack cover (1-2) is arranged on the side surface of the rack (1-1); the supporting frame (1-3) is arranged on the top surface of the rack (1-1), and the supporting frame (1-3) and the rack (1-1) are arranged in a rotatable manner; the dry heating block (1-4) is fixed on the inner side of the support frame (1-3); the heating guide sleeve (1-5) is arranged in the dry heating block (1-4); each flow cell (1-6) is respectively inserted into the heating guide sleeve (1-5);
the solvent heating system (2) is used for receiving and storing the solvent released by the drug circulation system (1) and carrying out constant temperature treatment on the solvent; comprises a heating box (2-1), a heating wire (2-2), a dissolving cup rack (2-3) and a solvent cup (2-4); the heating wire (2-2) is arranged in the heating box (2-1); the dissolving cup rack (2-3) is fixedly arranged at the top end of the heating box (2-1), and the solvent cup (2-4) is fixedly inserted into the dissolving cup rack (2-3);
the sampling system (3) is used for sampling the menstruum released by the medicine flowing system (1); comprises a sampling mechanism (3-1), a sampling valve (3-2) and a sampling pump (3-3);
the inlet of the flow cell (1-6) is communicated with the outlet of the solvent cup (2-4) through a pipeline, the inlet pipeline of the flow cell (1-6) is communicated with a circulating pump (1-7), and the outlet of the flow cell (1-6) is communicated with the inlet of the solvent cup (2-4) through a pipeline; the inlet of the sampling mechanism (3-1) is communicated with the sampling port of the solvent cup (2-4) through a pipeline, and the inlet pipeline of the sampling mechanism (3-1) is connected with a sampling valve (3-2).
2. The automatic drug testing system adopting the flow cell method as claimed in claim 1, wherein a solvent inlet pipe (1-1-1) is arranged on the bottom surface of one side of the rack (1-1), the solvent inlet pipe (1-1-1) corresponds to the bottom end of each flow cell (1-6), and pipeline communication is realized by splicing joints; a solvent outlet pipe (1-1-2) is arranged on one side of the top end of the frame (1-1), the solvent outlet pipe (1-1-2) corresponds to the top end of each flow cell (1-6), and pipeline communication is achieved through plug insertion.
3. The flow cell method drug automatic test system according to claim 1, stepping motors (1-1-3) are embedded in the bottom surface of one side of the rack (1-1), each stepping motor (1-1-3) is correspondingly arranged at the bottom end of each flow cell (1-6), a rotating disc (1-1-4) is arranged at the end part of each stepping motor (1-1-3), the rotating disc (1-1-4) and the stepping motor (1-1-3) rotate coaxially, magnetic poles (1-1-5) are arranged on two sides of the top surface of the rotating disc (1-1-4), and the magnetic poles (1-1-5) and the rotating disc (1-1-4) are fixedly arranged; the top surface of the rotating disc (1-1-4) is provided with a shade (1-1-6), and the shade (1-1-6) is fixed with the bottom surface of the rack (1-1) through bolts.
4. The flow cell method drug automatic test system according to claim 2 or 3, wherein the number of the dry heating blocks (1-4) is plural, and the dry heating blocks are arranged in a transverse array; the number of the heating guide sleeves (1-5) is multiple; the number of the flow-through cells (1-6) is multiple; the number of the solvent inlet pipes (1-1-1) is multiple; the number of the solvent outlet pipes (1-1-2) is multiple; the number of the stepping motors (1-1-3) is multiple; the number of the solvent cups (2-4) is multiple; the dry heating blocks (1-4), the heating guide sleeves (1-5), the flow cells (1-6), the solvent inlet pipes (1-1-1), the solvent outlet pipes (1-1-2), the stepping motors (1-1-3) and the solvent cups (2-4) are consistent in number.
5. The flow cell method automatic drug testing system according to claim 1, wherein the supporting frame (1-3) comprises a fixed base (1-3-1) and a movable frame (1-3-2), the fixed base (1-3-1) is arranged on two sides of the top surface of the frame (1-1), and the fixed base (1-3-1) on each side is vertically arranged with the frame (1-1) through a bolt; the movable frame (1-3-2) is arranged between the fixed seats (1-3-1) at two sides, and the bottom ends at two sides of the movable frame (1-3-2) respectively rotate with the fixed seats (1-3-1) through rotating shafts.
6. The flow cell method automatic drug testing system according to claim 5, wherein the top surface of the support frame (1-3) is further provided with a pressing mechanism (1-7), and the pressing mechanism (1-7) comprises an edge plate (1-7-1), a center block (1-7-2), a rotating plate (1-7-3), a threaded cylinder (1-7-4), a star-shaped handle (1-7-5) and a pressing block (1-7-6); the edge plates (1-7-1) are arranged at two sides of the top end of the movable frame (1-3-2), and the edge plates (1-7-1) are fixedly arranged with the movable frame (1-3-2) through bolts respectively; the center block (1-7-2) is fixedly arranged at the center of the top side of the movable frame (1-3-2), the section of the center block (1-7-2) is of an I-shaped structure, and two sides of the center block (1-7-2) form a center block clamping groove (1-7-2-1); the rotating plates (1-7-3) are arranged on the top sides of the movable frames (1-3-2), one corner of each rotating plate (1-7-3) is rotatably arranged with one corner of each edge plate (1-7-1) through a bolt, and the edge plates (1-7-1) are rotatably embedded into the clamping grooves (1-7-2-1) of the central block; the threaded cylinder (1-7-4) is arranged at the bottom end of the rotating plate (1-7-3) and is fixedly arranged with the rotating plate (1-7-3), and the threaded cylinder (1-7-4) penetrates through the rotating plate (1-7-3); the star-shaped handle (1-7-5) penetrates through the threaded cylinder (1-7-4) and is in threaded connection with the threaded cylinder (1-7-4), and the bottom end of the star-shaped handle (1-7-5) extends out of the bottom end of the rotating plate (1-7-3); the pressing block (1-7-6) is fixedly arranged at the bottom end of the star-shaped handle (1-7-5).
7. The flow cell method automatic drug testing system according to claim 1, wherein one side of the dry heating block (1-4) is provided with an upright latch mechanism (1-8), and the upright latch mechanism (1-8) comprises a latch block (1-8-1), a latch rod (1-8-2), a latch handle (1-8-3), an upper limit block (1-8-4), a lower limit block (1-8-5) and a spring (1-8-6); the latch block (1-8-1) is vertically assembled with one dry heating block (1-4) through a bolt; the latch rod (1-8-2) penetrates through the latch block (1-8-1), is vertically arranged and is slidably arranged with the latch block (1-8-1); the mortise lock handle (1-8-3) is arranged on one side of the top end of the mortise lock rod (1-8-2); the upper limiting block (1-8-4) is fixedly arranged on the outer wall of the top end of the insertion locking rod (1-8-2); the lower limiting block (1-8-5) is arranged on the outer wall of the bottom end of the insertion locking rod (1-8-2); the spring (1-8-6) is sleeved on the outer wall of the latch rod (1-8-2), the top end of the spring (1-8-6) abuts against the bottom surface of the latch block (1-8-1), and the bottom end of the spring (1-8-6) abuts against the top surface of the lower limiting block (1-8-5); the bottom surface one side of frame (1-1) still is equipped with locking piece (1-1-7), locking piece (1-1-7) through the bolt with frame (1-1) fixed assembly, the top surface of locking piece (1-1-7) is equipped with locking hole (1-1-7-1), locking bar (1-8-2) cuttage in locking hole (1-1-7-1), realize upright locking mechanism (1-8) is fixed with frame (1-1).
8. The flow cell method automatic drug testing system according to claim 1, wherein when the rack (1-1) is in a vertical position, the upper part of the flow cell (1-6) is provided with filter layers (1-6-1) in sequence from bottom to top, and the number of the filter layers (1-6-1) is multiple.
9. A test method of a flow cell method drug automatic test system comprises the following steps:
(1) placing dissolved medicines (such as tablets and capsules) into a flow cell (1-6), placing a magnetic stirrer into the flow cell (1-6), and sleeving a heating guide sleeve (1-5) on the outer wall of the flow cell (1-6); the flow cell (1-6) and the heating guide sleeve (1-5) are inserted into the dry heating block (1-4) together;
(2) rotating the support frame (1-3), relatively rotating the movable frame (1-3-2) and the fixed seat (1-3-1) to enable the movable frame (1-3-2) to be in a vertical state, adjusting the vertical mortise lock mechanism (1-8), lifting the mortise lock rod (1-8-2) upwards by pulling the mortise lock handle (1-8-3) with a hand, enabling the lower limit block (1-8-5) to abut against the spring (1-8-6) to be in a yield state, aligning the bottom end of the mortise lock rod (1-8-2) with the locking hole (1-1-7-1), enabling the spring (1-8-6) to recover to deform after the mortise lock handle (1-8-3) is released, pushing the mortise lock rod (1-8-2) to be inserted into the locking hole (1-1-7-1), the bottom surface of the upper limiting block (1-8-4) is attached to the top surface of the mortise lock block (1-8-1), and the support frame (1-3) is vertically locked with the rack (1-1) through the vertical mortise lock mechanism (1-8);
(3) adjusting a pressing mechanism (1-7), rotating a rotating plate (1-7-3) and embedding the rotating plate into a central block clamping groove (1-7-2-1) for fixing, rotating and adjusting a star-shaped handle (1-7-5) to be matched with a threaded cylinder (1-7-4), driving a pressing block (1-7-6) to press down and abut against the top end of a flow cell (1-6) by the star-shaped handle (1-7-5), and abutting and fixing the flow cell (1-6) and a dry heating block (1-4) by the pressing mechanism (1-7);
(4) the bottom end of the flow cell (1-6) is spliced and communicated with the solvent inlet pipe (1-1-1), and the top end of the flow cell (1-6) is spliced and communicated with the solvent outlet pipe (1-1-2);
(5) starting the heating heater strip (2-2), heating the water area in the heating box (2-1) to control the temperature of the solvent in the solvent cup (2-4) to be 37 ℃;
(6) starting the circulating pump (1-7), enabling the solvent in the solvent cup (2-4) to enter the circulating pool (1-6) through the solvent inlet pipe (1-1-1) under the circulating action of the circulating pump (1-7) by the circulating pump (1-7), and discharging the dissolved solvent and the dissolved medicine to the solvent cup (2-4) through the solvent outlet pipe (1-1-2);
(7) starting a stepping motor (1-1-3), driving a rotating disk (1-1-4) to rotate by the stepping motor (1-1-3), driving a magnetic stirrer in a flow cell (1-6) to rotate by a magnetic pole (1-1-5) along with the rotating disk (1-1-4), and increasing the disturbance degree of a solvent flowing through the flow cell (1-6) by the magnetic pole (1-1-5);
(8) starting the sampling pump (3-3) and the sampling valve (3-2), and pumping the solvent in the solvent cup (2-4) into the sampling mechanism (3-1) by the sampling pump (3-3) to realize the sampling process.
10. A test method of a flow cell method drug automatic test system comprises the following steps:
(1) placing the dissolved medicine (such as microspheres, suppositories and suspensions) into the flow cell (1-6), and sleeving the heating guide sleeve (1-5) on the outer wall of the flow cell (1-6); the flow cell (1-6) and the heating guide sleeve (1-5) are inserted into the dry heating block (1-4) together;
(2) adjusting a pressing mechanism (1-7), rotating a rotating plate (1-7-3) and embedding the rotating plate into a central block clamping groove (1-7-2-1) for fixing, rotating and adjusting a star-shaped handle (1-7-5) to be matched with a threaded cylinder (1-7-4), driving a pressing block (1-7-6) to press down and abut against the top end of a flow cell (1-6) by the star-shaped handle (1-7-5), and abutting and fixing the flow cell (1-6) and a dry heating block (1-4) by the pressing mechanism (1-7);
(3) rotating the support frame (1-3), and enabling the movable frame (1-3-2) and the fixed seat (1-3-1) to rotate relatively to enable the movable frame (1-3-2) to be attached to the top surface of the rack (1-1) to be in a transverse state;
(4) the bottom end of the flow cell (1-6) is spliced and communicated with the solvent inlet pipe (1-1-1), and the top end of the flow cell (1-6) is spliced and communicated with the solvent outlet pipe (1-1-2);
(5) starting the heating heater strip (2-2), heating the water area in the heating box (2-1) to control the temperature of the solvent in the solvent cup (2-4) to be 37 ℃;
(6) starting the circulating pump (1-7), enabling the solvent in the solvent cup (2-4) to enter the circulating pool (1-6) through the solvent inlet pipe (1-1-1) under the circulating action of the circulating pump (1-7) by the circulating pump (1-7), and discharging the dissolved solvent and the dissolved medicine to the solvent cup (2-4) through the solvent outlet pipe (1-1-2);
(7) starting the sampling pump (3-3) and the sampling valve (3-2), and pumping the solvent in the solvent cup (2-4) into the sampling mechanism (3-1) by the sampling pump (3-3) to realize the sampling process.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010907794.5A CN112114100A (en) | 2020-09-02 | 2020-09-02 | Automatic drug testing system and method by flow cell method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010907794.5A CN112114100A (en) | 2020-09-02 | 2020-09-02 | Automatic drug testing system and method by flow cell method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112114100A true CN112114100A (en) | 2020-12-22 |
Family
ID=73805159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010907794.5A Pending CN112114100A (en) | 2020-09-02 | 2020-09-02 | Automatic drug testing system and method by flow cell method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112114100A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113009094A (en) * | 2021-02-03 | 2021-06-22 | 禄根仪器(镇江)有限公司 | Novel high-efficient medicine dissolves out appearance |
| CN113433277A (en) * | 2021-08-08 | 2021-09-24 | 湖南慧泽生物医药科技有限公司 | Circulating dissolution instrument system for in-vitro dissolution of medicine and method for detecting dissolution of medicine |
-
2020
- 2020-09-02 CN CN202010907794.5A patent/CN112114100A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113009094A (en) * | 2021-02-03 | 2021-06-22 | 禄根仪器(镇江)有限公司 | Novel high-efficient medicine dissolves out appearance |
| CN113433277A (en) * | 2021-08-08 | 2021-09-24 | 湖南慧泽生物医药科技有限公司 | Circulating dissolution instrument system for in-vitro dissolution of medicine and method for detecting dissolution of medicine |
| CN113433277B (en) * | 2021-08-08 | 2022-04-01 | 湖南慧泽生物医药科技有限公司 | Circulating dissolution instrument system for in-vitro dissolution of medicine and method for detecting dissolution of medicine |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112114100A (en) | Automatic drug testing system and method by flow cell method | |
| CN211538888U (en) | Test tube cleaning device for medical treatment | |
| CN214622579U (en) | Automatic drug testing system adopting flow cell method | |
| US20070292309A1 (en) | Pharmaceutical product release rate testing device | |
| CN109596406A (en) | A kind of first test examination instrument of oncology clinic | |
| CN113786901B (en) | Medicine milling equipment for pediatric medical treatment | |
| CN116004363A (en) | Exosome filters extraction element | |
| CN211553956U (en) | Drug absorption system | |
| CN112113800A (en) | Closed-loop sampling system for drug dissolution by flow cell method and use method | |
| CN110756528A (en) | Be used for experiment test tube processing apparatus that decontaminates | |
| CN115290493A (en) | Tempered glass heat resistance detection system | |
| CN210878863U (en) | Based on filter equipment for digit control machine tool | |
| CN112587750A (en) | Infusion system capable of automatically replacing bottles | |
| CN103849549B (en) | For extracting grabbing device and the instrument thereof of the instrument of bioactive substance | |
| CN215767804U (en) | Closed-loop sampling system for drug dissolution by flow cell method | |
| CN112451851A (en) | Scar removing device for medical cosmetology department | |
| CN213875636U (en) | Flow cell method medicine dissolving out device | |
| CN113477294A (en) | Sample storage device for blood transfusion inspection of blood station | |
| CN112114099A (en) | Flow cell method medicine dissolving out device | |
| CN219776219U (en) | Prevent calcium fruit leaf drying-machine of damage | |
| CN218013390U (en) | Medical science clinical laboratory centrifugal equipment | |
| CN221385949U (en) | Veterinary drug sample detection frame | |
| CN216821714U (en) | Dried bean soaking mechanism convenient to material loading | |
| CN213875635U (en) | Solvent switching system of flow cell method | |
| CN220188176U (en) | Blood tumor marker analysis device |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CB02 | Change of applicant information | ||
| CB02 | Change of applicant information |
Address after: No. 159, Taigu Road, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai, 200120 Applicant after: Lugen (Shanghai) Life Technology Co.,Ltd. Address before: Part A2, 1 / F, No. 205, Taigu Road, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai, 200120 Applicant before: Lugen (Shanghai) International Trade Co.,Ltd. |