CN112107552A - Diprophylline tablet and preparation method thereof - Google Patents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
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- A—HUMAN NECESSITIES
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Abstract
The invention discloses a diprophylline tablet and a preparation method thereof, comprising the following steps of S01: preparing materials, namely diprophylline powder, purified water, a mould and a compression tank, and performing step S02: mixing and compressing the raw materials in a compression tank, and step S03: dehydrating and drying the compressed solution in a drying device, and step S04: filling the reactant dried to slurry into the mold, and step S05: collecting the reactant which cannot be added into the mold into a circulating collection device, and carrying out step S06: vacuum filtering the waste material in the recycling collection device, step S07: the invention realizes that the raw material waste is reduced in the preparation process of the dihydroxypropane theophylline tablet, and simultaneously realizes the recycling of the main raw material through circulating filtration, thereby avoiding the waste of the main raw material in the production process, and the product quality is far beyond the same kind of industrial products because the efficiency and the concentration of the dihydroxypropane theophylline tablet are improved due to compression.
Description
Technical Field
The invention belongs to the field, and particularly relates to a diprophylline tablet and a preparation method thereof.
Background
Asthma is a common respiratory disease and is also a frequently encountered disease. More than 1 hundred million asthmatics exist all over the world, the prevalence rate of the asthma in China is close to 1 percent, the prevalence number is more than ten million, and half of the asthma attacks before the age of 12. Asthma is a disease which seriously harms physical and mental health of people, weakens labor capacity and reduces life quality, and is difficult to be cured radically. It is manifested as sudden chest tightness, irritable cough and dyspnea with wheezing sound mainly in exhalation. The attack time can be long or short, and the severe attack time can last for weeks, or the attack time can be repeated to form a chronic process.
The dihypropizine tablet in the current market has the characteristics of incomplete dissociation due to the conventional preparation process technology and the reasons of materials and compound additives, and has the disadvantages of complicated preparation process and high cost. In order to solve the above problems, the present invention provides a diprophylline tablet and a preparation method thereof, and therefore, in order to solve the above problems, we provide a diprophylline tablet and a preparation method thereof.
Disclosure of Invention
The invention provides a diprophylline tablet and a preparation method thereof, aiming at solving the problems that the dissociation cannot be fully performed, the preparation process is complicated and the cost is high due to the existence of materials and compound additives.
The invention is realized in such a way, 1, the dihydroxypropane theophylline tablet and the preparation method thereof comprise the following steps:
step S01: preparing materials, namely taking diprophylline powder, purified water, starch, magnesium stearate, loquat syrup, bulbus fritilariae, a lubricant, vitamin C, vitamin E and an antioxidant;
step S02: fully mixing dyphylline and water in a mixing tank, sequentially adding loquat syrup, bulbus fritilariae, vitamin C, vitamin E and starch, fully mixing the mixed solution through a stirring shaft, feeding the mixed solution into a concentration tank, and concentrating the mixed solution;
step S03: preliminarily dehydrating and drying the concentrated mixed solution in a drying device to be in a slurry state;
step S04: the slurry mixture is loaded into a sheet-like mold plate and sufficiently dried so that the slurry mixture becomes a sheet:
step S05: collecting the slurry mixture overflowing from the surface of the sheet-shaped die plate into a waste recovery device:
step S06: the slurry mixture is subjected to low-temperature drying to remove impurities in the slurry mixture, and is circulated into the mixing tank in step S02:
step S07: through the fully dried cake, through the product collector into a collection device.
Further, in the step S01, the diprophylline powder and the purified water are used as raw materials, a recovery device is prepared in advance, and the stearic acid family is used as the lubricant, the loquat syrup, the bulbus fritilariae, the vitamin C and the vitamin E are used as auxiliary materials.
Further, in the step S02, the mixing tank fully mixes the mixed solution inside the mixing tank through the stirring shaft and the heating rod at the periphery of the mixing tank, and adds the fully mixed and filtered mixed solution into the concentration tank, and the mixed solution is primarily dehydrated and concentrated through the concentration tank.
Further, the drying device in the step S03 is a drying kettle, a heating rod is installed on the outer surface of the drying kettle, a stirring shaft is installed in the inner cavity of the drying kettle, and the dried slurry mixture is obtained.
Further, the step S04 is to uniformly coat magnesium stearate on the inner surface of the sheet mold, and completely fill the slurry mixture into the sheet mold.
Further, the step S05 scrapes off the slurry mixture overflowing from the sheet mold in the step S04 by a scraper. And collecting the scraped slurry mixture into a waste collection device.
Further, the scrap collecting apparatus of step S06 is provided with a vacuum filtering apparatus therein to remove impurities from the scraped scrap, and the scrap from which the impurities are removed is recycled and added to the mixing tank of step S02, and the recycled materials and the mixed materials are sufficiently mixed via the mixing tank.
Further, in the step S01, the raw materials are mixed in proportion as follows: 65-70 parts of diprophylline, 3-5 parts of loquat syrup, 3-5 parts of bulbus fritilariae, 10-15 parts of purified water, 3-5 parts of vitamin C, 1.5-3 parts of vitamin E, 0.3-0.5 part of antioxidant, 10-15 parts of starch and 1-3 parts of magnesium stearate.
Further, magnesium stearate uniformly applied to the surface of the tablet-shaped mold can be uniformly adhered to the surface of the tablet after the tablet is completely dried, so that the dihydroxypropyl theophylline tablet is obtained.
Further, the magnesium stearate, the loquat dew and the bulbus fritilariae are cleaned, dried in vacuum at low temperature, fully crushed in a wall breaking and crushing device to prepare a filling agent, the diprophylline and the filling agent are uniformly mixed, purified water is added to prepare a soft material, and the antioxidant, the vitamin C, the vitamin E, the starch and the magnesium stearate are added into the soft material to prepare a slurry mixture.
Compared with the prior art, the invention has the beneficial effects that:
the invention provides a dihydroxypropane theophylline tablet and a preparation method thereof, wherein vitamin C and vitamin E are added into auxiliary materials of the dihydroxypropane theophylline tablet, so that the immunocompetence of a patient can be improved and the recovery capability of the patient can be improved while the patient is treated, the storage period of a medicine is maintained by adding aviation oxidant, the main body of the whole tablet is formed by starch, the dihydroxypropane theophylline tablet has high bioavailability, stable disintegration and dissolution speed, stable quality, stable drug effect release speed, convenient carrying and taking, few types of auxiliary materials, few production flows, low production cost and high production efficiency.
Drawings
FIG. 1 is a process flow diagram of a diprophylline tablet and a preparation method thereof.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
In the description of the present invention, it is to be understood that the terms "length", "width", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships illustrated in the drawings, and are used merely for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, are not to be construed as limiting the present invention. Further, in the description of the present invention, "a plurality" means two or more unless specifically defined otherwise.
Example 1
Referring to fig. 1, the present invention provides a technical solution: a dihydroxypropane theophylline tablet and a preparation method thereof comprise the following steps:
step S01: preparing materials, namely taking diprophylline powder, purified water, starch, magnesium stearate, loquat syrup, bulbus fritilariae, a lubricant, vitamin C, vitamin E and an antioxidant;
step S02: fully mixing dyphylline and water in a mixing tank, sequentially adding loquat syrup, bulbus fritilariae, vitamin C, vitamin E and starch, fully mixing the mixed solution through a stirring shaft, feeding the mixed solution into a concentration tank, and concentrating the mixed solution;
step S03: preliminarily dehydrating and drying the concentrated mixed solution in a drying device to be in a slurry state;
step S04: the slurry mixture is loaded into a sheet-like mold plate and sufficiently dried so that the slurry mixture becomes a sheet:
step S05: collecting the slurry mixture overflowing from the surface of the sheet-shaped die plate into a waste recovery device:
step S06: the slurry mixture is subjected to low-temperature drying to remove impurities in the slurry mixture, and is circulated into the mixing tank in step S02:
step S07: through abundant dry sheeting, in getting into collection device through the finished product collector, two hydroxypropyl theophylline powder and purified water are the raw materials to prepare recovery unit in advance, the stearic acid family is emollient, the loquat dew, tendril-leaved fritillary bulb, vitamin C, and vitamin E are the auxiliary material, the raw and auxiliary materials ratio is: 65-70 parts of diprophylline, 3-5 parts of loquat syrup, 3-5 parts of bulbus fritilariae, 10-15 parts of purified water, 3-5 parts of vitamin C, 1.5-3 parts of vitamin E, 0.3-0.5 part of antioxidant, 10-15 parts of starch and 1-3 parts of magnesium stearate.
Example 2
Step S01: preparing materials, namely taking diprophylline powder, purified water, starch, magnesium stearate, loquat syrup, bulbus fritilariae, a lubricant, vitamin C, vitamin E and an antioxidant;
step S02: fully mixing dyphylline and water in a mixing tank, sequentially adding loquat syrup, bulbus fritilariae, vitamin C, vitamin E and starch, fully mixing the mixed solution through a stirring shaft, feeding the mixed solution into a concentration tank, and concentrating the mixed solution;
step S03: preliminarily dehydrating and drying the concentrated mixed solution in a drying device to be in a slurry state;
step S04: the slurry mixture is loaded into a sheet-like mold plate and sufficiently dried so that the slurry mixture becomes a sheet:
step S05: collecting the slurry mixture overflowing from the surface of the sheet-shaped die plate into a waste recovery device:
step S06: the slurry mixture is subjected to low-temperature drying to remove impurities in the slurry mixture, and is circulated into the mixing tank in step S02:
step S07: through abundant dry sheeting, in getting into collection device through the finished product collector, two hydroxypropyl theophylline powder and purified water are the raw materials to prepare recovery unit in advance, the stearic acid family is emollient, the loquat dew, tendril-leaved fritillary bulb, vitamin C, and vitamin E are the auxiliary material, the raw and auxiliary materials ratio is: 50-70 parts of diprophylline, 5-10 parts of loquat syrup, 5-8 parts of bulbus fritilariae, 15-20 parts of purified water, 5-10 parts of vitamin C, 3-5 parts of vitamin E, 0.2-0.4 part of antioxidant, 8-12 parts of starch and 0.5-2.5 parts of magnesium stearate.
Example 3
Step S01: preparing materials, namely taking diprophylline powder, purified water, starch, magnesium stearate, loquat syrup, bulbus fritilariae, a lubricant, vitamin C, vitamin E and an antioxidant;
step S02: fully mixing dyphylline and water in a mixing tank, sequentially adding loquat syrup, bulbus fritilariae, vitamin C, vitamin E and starch, fully mixing the mixed solution through a stirring shaft, feeding the mixed solution into a concentration tank, and concentrating the mixed solution;
step S03: preliminarily dehydrating and drying the concentrated mixed solution in a drying device to be in a slurry state;
step S04: the slurry mixture is loaded into a sheet-like mold plate and sufficiently dried so that the slurry mixture becomes a sheet:
step S05: collecting the slurry mixture overflowing from the surface of the sheet-shaped die plate into a waste recovery device:
step S06: the slurry mixture is subjected to low-temperature drying to remove impurities in the slurry mixture, and is circulated into the mixing tank in step S02:
step S07: through abundant dry sheeting, in getting into collection device through the finished product collector, two hydroxypropyl theophylline powder and purified water are the raw materials to prepare recovery unit in advance, the stearic acid family is emollient, the loquat dew, tendril-leaved fritillary bulb, vitamin C, and vitamin E are the auxiliary material, the raw and auxiliary materials ratio is: 65-70 parts of diprophylline, 3-5 parts of loquat syrup, 3-5 parts of bulbus fritilariae, 10-15 parts of purified water, 3-5 parts of vitamin C, 1.5-3 parts of vitamin E, 0.3-0.5 part of antioxidant, 10-15 parts of starch and 1-3 parts of magnesium stearate, wherein the pressure of a vacuum filtering device in the step S06 is 1MPa, the vacuum filtering time is 100 minutes, and the step S04 is in a vertically separated mode, and overflowed raw materials are discharged by extrusion.
Example 4
Step S01: preparing materials, namely taking diprophylline powder, purified water, starch, magnesium stearate, loquat syrup, bulbus fritilariae, a lubricant, vitamin C, vitamin E and an antioxidant;
step S02: fully mixing dyphylline and water in a mixing tank, sequentially adding loquat syrup, bulbus fritilariae, vitamin C, vitamin E and starch, fully mixing the mixed solution through a stirring shaft, feeding the mixed solution into a concentration tank, and concentrating the mixed solution;
step S03: preliminarily dehydrating and drying the concentrated mixed solution in a drying device to be in a slurry state;
step S04: the slurry mixture is loaded into a sheet-like mold plate and sufficiently dried so that the slurry mixture becomes a sheet:
step S05: collecting the slurry mixture overflowing from the surface of the sheet-shaped die plate into a waste recovery device:
step S06: the slurry mixture is subjected to low-temperature drying to remove impurities in the slurry mixture, and is circulated into the mixing tank in step S02:
step S07: through abundant dry sheeting, in getting into collection device through the finished product collector, two hydroxypropyl theophylline powder and purified water are the raw materials to prepare recovery unit in advance, the stearic acid family is emollient, the loquat dew, tendril-leaved fritillary bulb, vitamin C, and vitamin E are the auxiliary material, the raw and auxiliary materials ratio is: 50-70 parts of diprophylline, 5-10 parts of loquat syrup, 5-8 parts of bulbus fritilariae, 15-20 parts of purified water, 5-10 parts of vitamin C, 3-5 parts of vitamin E, 0.2-0.4 part of antioxidant, 8-12 parts of starch and 0.5-2.5 parts of magnesium stearate, wherein the pressure of a vacuum filtering device in the step S06 is 1MPa, the vacuum filtering time is 100 minutes, the step S04 is of a vertically separated type, and overflowing raw materials are discharged by extrusion.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A diprophylline tablet and a preparation method thereof comprise the following steps:
step S01: preparing materials, namely taking diprophylline powder, purified water, starch, magnesium stearate, loquat syrup, bulbus fritilariae, vitamin C, vitamin E and antioxidant;
step S02: fully mixing dyphylline and water in a mixing tank, sequentially adding loquat syrup, bulbus fritilariae, vitamin C, vitamin E and starch, fully mixing the mixed solution through a stirring shaft, feeding the mixed solution into a concentration tank, and concentrating the mixed solution;
step S03: preliminarily dehydrating and drying the concentrated mixed solution in a drying device to be in a slurry state;
step S04: the slurry mixture is loaded into a sheet-like mold plate and sufficiently dried so that the slurry mixture becomes a sheet:
step S05: collecting the slurry mixture overflowing from the surface of the sheet-shaped die plate into a waste recovery device:
step S06: the slurry mixture is subjected to low-temperature drying to remove impurities in the slurry mixture, and is circulated into the mixing tank in step S02:
step S07: through the fully dried cake, through the product collector into a collection device.
2. The diprophylline tablet and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: in the step S01, the diprophylline powder and the purified water are used as raw materials, and a recovery device is prepared in advance, the stearate is used as a lubricant, and the loquat syrup, the bulbus fritilariae, the vitamin C and the vitamin E are used as auxiliary materials.
3. The diprophylline tablet and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: and in the step S02, the mixing tank fully mixes the mixed solution in the mixing tank through a stirring shaft and a heating rod on the periphery of the mixing tank, the fully mixed and filtered mixed solution is added into a concentration tank, and the mixed solution is preliminarily dehydrated and concentrated through the concentration tank.
4. The diprophylline tablet and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: the drying device in the step S03 is a drying kettle, a heating rod is arranged on the outer surface of the drying kettle, a stirring shaft is arranged in the inner cavity of the drying kettle, and the dried slurry mixture is obtained.
5. The diprophylline tablet and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: the step S04 is to uniformly coat the magnesium stearate on the inner surface of the sheet-shaped mold, and to completely fill the slurry-like mixture into the sheet-shaped mold.
6. The diprophylline tablet and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: the step S05 scrapes off the slurry mixture overflowing from the sheet mold in the step S04 by a scraper. And collecting the scraped slurry mixture into a waste collection device.
7. The diprophylline tablet and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: the step S06 is to install a vacuum filtering device in the scrap collecting device to remove impurities in the scraped scrap, and to add the scrap after removing impurities to the mixing tank of the step S02, and to mix the recycled materials with the mixed materials through the mixing tank.
8. The diprophylline tablet and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: the raw materials in the step S01 are proportioned as follows: 65-70 parts of diprophylline, 3-5 parts of loquat syrup, 3-5 parts of bulbus fritilariae, 10-15 parts of purified water, 3-5 parts of vitamin C, 1.5-3 parts of vitamin E, 0.3-0.5 part of antioxidant, 10-15 parts of starch and 1-3 parts of magnesium stearate.
9. The diprophylline tablet and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: the magnesium stearate is uniformly coated on the surface of the sheet-shaped mould, and the magnesium stearate can be uniformly adhered on the surface of the completely dried tablet to obtain the dihydroxyl propyltheonine tablet.
10. The diprophylline tablet and the preparation method thereof according to claim 1, wherein the preparation method comprises the following steps: cleaning magnesium stearate, loquat dew and bulbus fritilariae, drying in vacuum at low temperature, fully crushing in a wall breaking and crushing device to prepare a filling agent, uniformly mixing diprophylline and the filling agent, adding purified water to prepare a soft material, adding antioxidant, vitamin C, vitamin E, starch and magnesium stearate into the soft material to prepare a slurry mixture.
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| CN202010633885.4A CN112107552A (en) | 2020-07-02 | 2020-07-02 | Diprophylline tablet and preparation method thereof |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079498A (en) * | 2015-09-17 | 2015-11-25 | 合肥微信片农业科技有限公司 | Dendrobe chewable tablet |
| CN107823410A (en) * | 2017-11-28 | 2018-03-23 | 华益药业科技(安徽)有限公司 | A kind of Diprophylline tablet and preparation method thereof |
-
2020
- 2020-07-02 CN CN202010633885.4A patent/CN112107552A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105079498A (en) * | 2015-09-17 | 2015-11-25 | 合肥微信片农业科技有限公司 | Dendrobe chewable tablet |
| CN107823410A (en) * | 2017-11-28 | 2018-03-23 | 华益药业科技(安徽)有限公司 | A kind of Diprophylline tablet and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 刘立华主编: "《制药工程专业实验》", 31 July 2018, 中国矿业大学出版社 * |
| 王伟主编: "《肿瘤药剂学》", 30 November 2017, 江苏凤凰科学技术出版社 * |
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