CN112105622A - 丙戊酸磷脂衍生物的新晶型及其制备方法 - Google Patents
丙戊酸磷脂衍生物的新晶型及其制备方法 Download PDFInfo
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- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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- C07F9/09—Esters of phosphoric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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Abstract
提供了丙戊酸磷脂衍生物DP‑VPA‑C16和DP‑VPA‑C18混合物的晶型A和B、包含该晶型的药物组合物、制备方法以及所述晶型在制备用于治疗癫痫、偏头痛、两极细胞病或疼痛的药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (21)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018104013530 | 2018-04-28 | ||
| CN201810401353.0A CN110407867A (zh) | 2018-04-28 | 2018-04-28 | 丙戊酸磷脂衍生物的新晶型及其制备方法 |
| PCT/CN2019/084506 WO2019206266A1 (zh) | 2018-04-28 | 2019-04-26 | 丙戊酸磷脂衍生物的晶型及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112105622A true CN112105622A (zh) | 2020-12-18 |
| CN112105622B CN112105622B (zh) | 2022-05-24 |
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|---|---|---|---|
| CN201810401353.0A Pending CN110407867A (zh) | 2018-04-28 | 2018-04-28 | 丙戊酸磷脂衍生物的新晶型及其制备方法 |
| CN201980028331.7A Active CN112105622B (zh) | 2018-04-28 | 2019-04-26 | 丙戊酸磷脂衍生物的晶型及其制备方法 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810401353.0A Pending CN110407867A (zh) | 2018-04-28 | 2018-04-28 | 丙戊酸磷脂衍生物的新晶型及其制备方法 |
Country Status (2)
| Country | Link |
|---|---|
| CN (2) | CN110407867A (zh) |
| WO (1) | WO2019206266A1 (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994022483A2 (en) * | 1993-03-31 | 1994-10-13 | D-Pharm, Ltd. | Prodrugs with enhanced penetration into cells |
| CN1774252A (zh) * | 2000-07-12 | 2006-05-17 | 迪-药品有限公司 | 丙戊酸的磷脂衍生物及其混合物 |
| CN104230981A (zh) * | 2013-06-20 | 2014-12-24 | 江苏恩华药业股份有限公司 | 丙戊酸磷脂衍生物的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108659037B (zh) * | 2017-03-31 | 2022-01-11 | 江苏恩华药业股份有限公司 | 丙戊酸磷脂衍生物的多晶型物及制备方法 |
| CN108659038B (zh) * | 2017-03-31 | 2022-01-11 | 江苏恩华药业股份有限公司 | 1-硬脂酰-2-丙戊酰-sn-甘油-3-磷脂酰胆碱的多晶型物及制备方法 |
-
2018
- 2018-04-28 CN CN201810401353.0A patent/CN110407867A/zh active Pending
-
2019
- 2019-04-26 CN CN201980028331.7A patent/CN112105622B/zh active Active
- 2019-04-26 WO PCT/CN2019/084506 patent/WO2019206266A1/zh active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994022483A2 (en) * | 1993-03-31 | 1994-10-13 | D-Pharm, Ltd. | Prodrugs with enhanced penetration into cells |
| CN1774252A (zh) * | 2000-07-12 | 2006-05-17 | 迪-药品有限公司 | 丙戊酸的磷脂衍生物及其混合物 |
| CN104230981A (zh) * | 2013-06-20 | 2014-12-24 | 江苏恩华药业股份有限公司 | 丙戊酸磷脂衍生物的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019206266A1 (zh) | 2019-10-31 |
| CN110407867A (zh) | 2019-11-05 |
| CN112105622B (zh) | 2022-05-24 |
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