CN112089822A - Traditional Chinese medicine preparation for conditioning premature ovarian failure of women and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for conditioning premature ovarian failure of women and preparation method thereof Download PDFInfo
- Publication number
- CN112089822A CN112089822A CN202011159678.6A CN202011159678A CN112089822A CN 112089822 A CN112089822 A CN 112089822A CN 202011159678 A CN202011159678 A CN 202011159678A CN 112089822 A CN112089822 A CN 112089822A
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- traditional chinese
- chinese medicine
- conditioning
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Abstract
The invention provides a traditional Chinese medicine preparation for conditioning premature ovarian failure and a preparation method thereof, belonging to the technical field of traditional Chinese medicine preparations, and the traditional Chinese medicine preparation for conditioning premature ovarian failure comprises the following raw material formulas in parts by weight: 1 part of vitamin composition, 10-15 parts of prepared rehmannia root, 4-9 parts of ginger, 13-15 parts of oldenlandia diffusa, 23-30 parts of nicotinamide, 12-16 parts of ash bark, 7-10 parts of inositol nicotinate, 8-13 parts of cistanche, 9-15 parts of flavone, 12-18 parts of tortoise shell, 15-24 parts of mulberry, 3-7 parts of keel, 2-8 parts of glutathione, 15-20 parts of codonopsis pilosula, 1-3 parts of amino acid, 14-19 parts of angelica, 13-18 parts of astragalus membranaceus, 12-19 parts of white paeony root, 21-26 parts of achyranthes root, 17-23 parts of eucommia bark, 15-19 parts of motherwort and 18-23 parts of szechwan chinaberry fruit; the device is convenient and simple to manufacture, has a remarkable effect on treating premature ovarian failure of women, and is not easy to produce side effects.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine preparation for conditioning premature ovarian failure of women and a preparation method thereof.
Background
Ovary (English: ovary; Latin: ovarium), anatomical noun, refers to a pair of sexual glands that make an egg in an animal female. Wherein human ovary is flat oval, gray pink red and similar to grape. It has two physiological functions, one is the production and discharge of ova, the other is the secretion of sex hormones, premature ovarian failure (premature ovarian failure) is a disease characterized by amenorrhea, infertility, estrogen deficiency and elevated gonadotropin levels in women before the age of 40. Clinically, the patients show amenorrhea and infertility, accompanied by flush, sweating due to fever, mood swings, leukorrhagia, etc. POF patients face a series of problems such as climacteric syndrome and infertility, and in addition, the risk of osteoporosis is increased, and the incidence rate of the disease tends to increase year by year, which seriously harms the physical and mental health of women. Hormone replacement therapy is generally given to the disease to maintain menstruation, female sexual characteristics and female sexual function, aims to relieve a series of symptoms caused by low estrogen level, and has unobvious curative effect and strong side effect.
The causes of premature ovarian failure are complex. The research on the etiology of the traditional Chinese medicine discovers that the kidney deficiency plays a leading role in premature ovarian failure, the deficiency of kidney qi and kidney essence is the main pathogenesis of the premature ovarian failure, and the important pathogenesis is the liver depression and spleen deficiency, the dark consumption of qi and blood, qi stagnation and blood stasis, Chong and ren disharmony and the like
The existing mode for treating premature ovarian failure is high in cost, weak in pertinence and large in side effect, so that the treatment effect is greatly reduced.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine preparation for conditioning premature ovarian failure and a preparation method thereof, and aims to solve the problems that the mode for treating premature ovarian failure in the prior art is high in cost, weak in pertinence and large in side effect, so that the treatment effect is greatly reduced.
In order to achieve the purpose, the invention provides the following technical scheme:
a traditional Chinese medicine preparation for conditioning premature ovarian failure of women comprises the following raw material formulas in parts by weight: 1 part of vitamin composition, 10-15 parts of prepared rehmannia root, 4-9 parts of ginger, 13-15 parts of oldenlandia diffusa, 23-30 parts of nicotinamide, 12-16 parts of ash bark, 7-10 parts of inositol nicotinate, 8-13 parts of cistanche, 9-15 parts of flavone, 12-18 parts of tortoise shell, 15-24 parts of mulberry, 3-7 parts of keel, 2-8 parts of glutathione, 15-20 parts of codonopsis pilosula, 1-3 parts of amino acid, 14-19 parts of angelica, 13-18 parts of astragalus membranaceus, 12-19 parts of white paeony root, 21-26 parts of achyranthes root, 17-23 parts of eucommia bark, 15-19 parts of motherwort and 18-23 parts of szechwan chinaberry fruit.
In a preferred embodiment of the present invention, the vitamin composition is prepared by mixing one or more of vitamin a, vitamin B, vitamin C, vitamin D and vitamin E in any ratio.
As a preferable scheme of the invention, the traditional Chinese medicine preparation comprises the following raw material formula in parts by weight: the vitamin composition comprises 1 part of vitamin composition, 10 parts of prepared rehmannia root, 4 parts of ginger, 13 parts of oldenlandia diffusa, 23 parts of nicotinamide, 12 parts of ash bark, 7 parts of inositol nicotinate, 8 parts of cistanche, 9 parts of flavone, 12 parts of tortoise shell, 15 parts of mulberry, 3 parts of keel, 2 parts of glutathione, 15 parts of codonopsis pilosula, 1 part of amino acid, 14 parts of angelica, 13 parts of astragalus, 12 parts of white paeony root, 21 parts of achyranthes root, 17 parts of eucommia bark, 15 parts of leonurus and 18 parts of szechwan chinaberry fruit.
As a preferable scheme of the present invention, the vitamin composition comprises 1 part of vitamin composition, 13 parts of prepared rehmannia root, 7 parts of ginger, 14 parts of oldenlandia diffusa, 27 parts of nicotinamide, 14 parts of ash bark, 8 parts of inositol nicotinate, 11 parts of cistanche, 13 parts of flavone, 15 parts of tortoise shell, 20 parts of mulberry fruit, 5 parts of keel, 5 parts of glutathione, 17 parts of codonopsis pilosula, 2 parts of amino acid, 17 parts of angelica, 16 parts of astragalus root, 16 parts of white peony root, 23 parts of achyranthes root, 20 parts of eucommia bark, 17 parts of motherwort and 21 parts of szechwan chinaberry fruit.
As a preferable scheme of the invention, the vitamin composition comprises 1 part of vitamin composition, 15 parts of prepared rehmannia root, 9 parts of ginger, 15 parts of oldenlandia diffusa, 30 parts of nicotinamide, 16 parts of ash bark, 10 parts of inositol nicotinate, 13 parts of cistanche, 15 parts of flavone, 18 parts of tortoise shell, 24 parts of mulberry fruit, 7 parts of keel, 8 parts of glutathione, 20 parts of codonopsis pilosula, 3 parts of amino acid, 19 parts of angelica, 18 parts of astragalus mongholicus, 19 parts of white peony root, 26 parts of achyranthes bidentata, 23 parts of eucommia ulmoides, 19 parts of leonurus and 23 parts of szechwan Chinaberry fruit.
As a preferable scheme of the invention, the traditional Chinese medicine preparation can be capsules, pills, suspensions, powders, tablets and granules.
As a preferable scheme of the invention, the preparation method of the traditional Chinese medicine preparation for conditioning the premature ovarian failure of the female comprises the following steps:
s1, cleaning and decocting: firstly, cleaning vitamin components, prepared rehmannia root, ginger, oldenlandia diffusa, nicotinamide, ash bark, inositol nicotinate, cistanche, flavone, tortoise shell, mulberry, keel, glutathione, codonopsis pilosula, amino acid, Chinese angelica, astragalus, white paeony root, achyranthes root, eucommia bark, motherwort and szechwan chinaberry fruit one by one according to the mass ratio in a pre-prepared mode, putting the cleaned raw materials into a medicine tank, adding deionized water into the medicine tank, and decocting to obtain a component A for later use;
s2, solid-liquid separation: performing solid-liquid separation on the component A prepared in the step S1 by a centrifugal method, removing residues in the component A, and obtaining clear liquid as a component B for later use;
s3, concentration: putting the component B into an evaporation pan for evaporation, so that the component B is concentrated;
s4, drying: placing the component B concentrated in the step S3 in a drying oven for drying to obtain a component C;
s5, crushing and grinding: pouring the dried third component in the step S4 into a ball mill, ball-milling for 13min at the ball-milling rotating speed of 348r/min, wherein the ball-material ratio is 5:12, and obtaining a fourth component after ball-milling;
s6, checking: and (4) encapsulating the component D prepared in the step (S5), and carrying out qualified inspection, wherein the capsule can be used after being qualified.
8. The traditional Chinese medicine preparation for conditioning premature ovarian failure of women as claimed in claim 7, wherein the decoction time is 2 h/time and the decoction is repeated twice when the decoction is carried out in step S1.
In a preferred embodiment of the present invention, in the step S1, the decoction time is 2 h/time, and the decoction is repeated twice.
As a preferable scheme of the invention, when the second decoction is carried out in the step S1, honey is added, and the weight ratio of the honey to the component A is 1: 20.
Compared with the prior art, the invention has the beneficial effects that:
1. by adding most of the traditional Chinese medicines, the traditional Chinese medicine capsule has a remarkable effect of treating premature ovarian failure of women after being prepared into capsules, and is not easy to generate side effects.
2. According to the scheme, the flavone, the vitamin composition and the glutathione are added, so that the prepared capsule can effectively activate the function of ovarian cells for a long time, repair special nutrient substances of atrophic ovaries, especially improve the secretion of female hormone and progestogen, and has an obvious curative effect.
3. According to the scheme, the honey is added, so that the taste of the oral liquid is improved when the oral liquid is prepared into pills or granules and the like, and the oral liquid is more smooth when the oral liquid is taken.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the principles of the invention and not to limit the invention. In the drawings:
FIG. 1 is a flow chart of a preparation method of a traditional Chinese medicine preparation for conditioning premature ovarian failure of women of the invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1:
referring to fig. 1, a traditional Chinese medicine preparation for conditioning premature ovarian failure of women comprises the following raw material formulas in parts by weight: the traditional Chinese medicine composition comprises, by weight, 1 part of a vitamin composition, 10 parts of prepared rehmannia root, 4 parts of ginger, 13 parts of oldenlandia diffusa, 23 parts of nicotinamide, 12 parts of ash bark, 7 parts of inositol nicotinate, 8 parts of cistanche, 9 parts of flavone, 12 parts of tortoise shell, 15 parts of mulberry, 3 parts of keel, 2 parts of glutathione, 15 parts of codonopsis pilosula, 1 part of amino acid, 14 parts of angelica, 13 parts of astragalus membranaceus, 12 parts of white paeony root, 21 parts of radix achyranthis bidentatae, 17 parts of eucommia ulmoides, 15 parts of leonurus and 18 parts of szechwan chinaberry.
A preparation method of a traditional Chinese medicine preparation for conditioning premature ovarian failure of women comprises the following steps:
s1, cleaning and decocting: firstly, cleaning vitamin components, prepared rehmannia root, ginger, oldenlandia diffusa, nicotinamide, ash bark, inositol nicotinate, cistanche, flavone, tortoise shell, mulberry, keel, glutathione, codonopsis pilosula, amino acid, Chinese angelica, astragalus, white paeony root, achyranthes root, eucommia bark, motherwort and szechwan chinaberry fruit one by one according to the mass ratio in a pre-prepared mode, putting the cleaned raw materials into a medicine tank, adding deionized water for decoction, adding water which is 3-5 times of the total weight during decoction, wherein the decoction time is 2 hours/time, repeatedly decocting twice to obtain a component A, and adding honey during second decoction, wherein the weight ratio of the honey to the component A is 1:20 for later use;
s2, solid-liquid separation: performing solid-liquid separation on the component A prepared in the step S1 by a centrifugal method, removing residues in the component A, and obtaining clear liquid as a component B for later use;
s3, concentration: putting the component B into an evaporation pan for evaporation, and carrying out normal pressure evaporation under a specified air pressure to concentrate the component B;
s4, drying: placing the component B concentrated in the step S3 in a drying oven for drying at 60-70 ℃ for 1-1.5h to obtain a component C;
s5, crushing and grinding: pouring the dried third component in the step S4 into a ball mill, ball-milling for 13min at the ball-milling rotating speed of 348r/min, wherein the ball-material ratio is 5:12, and obtaining a fourth component after ball-milling;
s6, checking: and (4) encapsulating the powdery butyl component prepared in the step (S5), and then carrying out professional medical qualification test, wherein the powdery butyl component can be used after being qualified.
Example 2:
the difference between the embodiment 2 and the embodiment 1 is that the content of the internal components is different, the preparation method is also adjusted adaptively according to the content of the components, and the traditional Chinese medicine preparation for conditioning the premature ovarian failure of women comprises the following raw material formulas in parts by weight: the vitamin composition comprises 1 part of vitamin composition, 13 parts of prepared rehmannia root, 7 parts of ginger, 14 parts of oldenlandia diffusa, 27 parts of nicotinamide, 14 parts of ash bark, 8 parts of inositol nicotinate, 11 parts of cistanche, 13 parts of flavone, 15 parts of tortoise shell, 20 parts of mulberry, 5 parts of keel, 5 parts of glutathione, 17 parts of codonopsis pilosula, 2 parts of amino acid, 17 parts of angelica, 16 parts of astragalus, 16 parts of white paeony root, 23 parts of achyranthes root, 20 parts of eucommia bark, 17 parts of leonurus and 21 parts of szechwan chinaberry fruit.
Example 3:
the difference between the embodiment 3 and the embodiment 1 is that the content of the internal components is different, the preparation method is also adjusted adaptively according to the content of the components, and the traditional Chinese medicine preparation for conditioning the premature ovarian failure of women comprises the following raw material formulas in parts by weight: the vitamin composition comprises 1 part of vitamin composition, 15 parts of prepared rehmannia root, 9 parts of ginger, 15 parts of oldenlandia diffusa, 30 parts of nicotinamide, 16 parts of ash bark, 10 parts of inositol nicotinate, 13 parts of cistanche, 15 parts of flavone, 18 parts of tortoise shell, 24 parts of mulberry, 7 parts of keel, 8 parts of glutathione, 20 parts of codonopsis pilosula, 3 parts of amino acid, 19 parts of angelica, 18 parts of astragalus, 19 parts of white peony root, 26 parts of achyranthes root, 23 parts of eucommia bark, 19 parts of leonurus and 23 parts of szechwan chinaberry fruit.
Specifically, the traditional Chinese medicine preparation for conditioning the premature ovarian failure of the female can be capsules, pills, suspensions, powder, tablets and granules, is preferably prepared into capsules, is convenient to take, has a remarkable effect on treating the premature ovarian failure of the female, and is not easy to generate side effects.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that changes may be made in the embodiments and/or equivalents thereof without departing from the spirit and scope of the invention. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (9)
1. The traditional Chinese medicine preparation for conditioning premature ovarian failure is characterized by comprising the following raw materials in parts by weight: 1 part of vitamin composition, 10-15 parts of prepared rehmannia root, 4-9 parts of ginger, 13-15 parts of oldenlandia diffusa, 23-30 parts of nicotinamide, 12-16 parts of ash bark, 7-10 parts of inositol nicotinate, 8-13 parts of cistanche, 9-15 parts of flavone, 12-18 parts of tortoise shell, 15-24 parts of mulberry, 3-7 parts of keel, 2-8 parts of glutathione, 15-20 parts of codonopsis pilosula, 1-3 parts of amino acid, 14-19 parts of angelica, 13-18 parts of astragalus membranaceus, 12-19 parts of white paeony root, 21-26 parts of achyranthes root, 17-23 parts of eucommia bark, 15-19 parts of motherwort and 18-23 parts of szechwan chinaberry fruit.
2. The traditional Chinese medicine preparation for conditioning premature ovarian failure of women as claimed in claim 1, wherein the vitamin composition is prepared by mixing one or more of vitamin A, vitamin B, vitamin C, vitamin D and vitamin E in any proportion.
3. The traditional Chinese medicine preparation for conditioning premature ovarian failure of women, as claimed in claim 1, is characterized by comprising the following raw material formula in parts by weight: the vitamin composition comprises 1 part of vitamin composition, 10 parts of prepared rehmannia root, 4 parts of ginger, 13 parts of oldenlandia diffusa, 23 parts of nicotinamide, 12 parts of ash bark, 7 parts of inositol nicotinate, 8 parts of cistanche, 9 parts of flavone, 12 parts of tortoise shell, 15 parts of mulberry, 3 parts of keel, 2 parts of glutathione, 15 parts of codonopsis pilosula, 1 part of amino acid, 14 parts of angelica, 13 parts of astragalus, 12 parts of white paeony root, 21 parts of achyranthes root, 17 parts of eucommia bark, 15 parts of leonurus and 18 parts of szechwan chinaberry fruit.
4. The traditional Chinese medicine preparation for conditioning premature ovarian failure of women, as claimed in claim 1, is characterized by comprising the following raw material formula in parts by weight: the vitamin composition comprises 1 part of vitamin composition, 13 parts of prepared rehmannia root, 7 parts of ginger, 14 parts of oldenlandia diffusa, 27 parts of nicotinamide, 14 parts of ash bark, 8 parts of inositol nicotinate, 11 parts of cistanche, 13 parts of flavone, 15 parts of tortoise shell, 20 parts of mulberry, 5 parts of keel, 5 parts of glutathione, 17 parts of codonopsis pilosula, 2 parts of amino acid, 17 parts of angelica, 16 parts of astragalus, 16 parts of white paeony root, 23 parts of achyranthes root, 20 parts of eucommia bark, 17 parts of leonurus and 21 parts of szechwan chinaberry fruit.
5. The traditional Chinese medicine preparation for conditioning premature ovarian failure of women, as claimed in claim 1, is characterized by comprising the following raw material formula in parts by weight: the vitamin composition comprises 1 part of vitamin composition, 15 parts of prepared rehmannia root, 9 parts of ginger, 15 parts of oldenlandia diffusa, 30 parts of nicotinamide, 16 parts of ash bark, 10 parts of inositol nicotinate, 13 parts of cistanche, 15 parts of flavone, 18 parts of tortoise shell, 24 parts of mulberry, 7 parts of keel, 8 parts of glutathione, 20 parts of codonopsis pilosula, 3 parts of amino acid, 19 parts of angelica, 18 parts of astragalus, 19 parts of white peony root, 26 parts of achyranthes root, 23 parts of eucommia bark, 19 parts of leonurus and 23 parts of szechwan chinaberry fruit.
6. The traditional Chinese medicine preparation for conditioning premature ovarian failure of women, as claimed in claim 1, wherein: the Chinese medicinal preparation can be capsule, pill, suspension, powder, tablet and granule.
7. The preparation method of the traditional Chinese medicine preparation for conditioning premature ovarian failure of the female according to any one of claims 1 to 6, is characterized by comprising the following steps of:
s1, cleaning and decocting: firstly, cleaning vitamin components, prepared rehmannia root, ginger, oldenlandia diffusa, nicotinamide, ash bark, inositol nicotinate, cistanche, flavone, tortoise shell, mulberry, keel, glutathione, codonopsis pilosula, amino acid, Chinese angelica, astragalus, white paeony root, achyranthes root, eucommia bark, motherwort and szechwan chinaberry fruit one by one according to the mass ratio in a pre-prepared mode, putting the cleaned raw materials into a medicine tank, adding deionized water into the medicine tank, and decocting to obtain a component A for later use;
s2, solid-liquid separation: performing solid-liquid separation on the component A prepared in the step S1 by a centrifugal method, removing residues in the component A, and obtaining clear liquid as a component B for later use;
s3, concentration: putting the component B into an evaporation pan for evaporation, so that the component B is concentrated;
s4, drying: placing the component B concentrated in the step S3 in a drying oven for drying to obtain a component C;
s5, crushing and grinding: pouring the dried third component in the step S4 into a ball mill, ball-milling for 13min at the ball-milling rotating speed of 348r/min, wherein the ball-material ratio is 5:12, and obtaining a fourth component after ball-milling;
s6, checking: and (4) encapsulating the component D prepared in the step (S5), and carrying out qualified inspection, wherein the capsule can be used after being qualified.
8. The traditional Chinese medicine preparation for conditioning premature ovarian failure of women as claimed in claim 7, wherein the decoction time is 2 h/time and the decoction is repeated twice when the decoction is carried out in step S1.
9. The traditional Chinese medicine preparation for conditioning premature ovarian failure of women, as claimed in claim 7, wherein: and in the step S1, adding honey when the second decoction is carried out, wherein the weight ratio of the honey to the component A is 1: 20.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688478A (en) * | 2012-06-09 | 2012-09-26 | 东莞市照燕生物科技有限公司 | Injection for treating premature ovarian failure |
| CN104027339A (en) * | 2014-06-12 | 2014-09-10 | 王淑芳 | Vitamin composition and application thereof in regulating ovarian function |
| CN105213467A (en) * | 2015-10-30 | 2016-01-06 | 张英杰 | A kind of Chinese medicine composition for the treatment of premature ovarian failure |
| CN105616561A (en) * | 2016-03-10 | 2016-06-01 | 王盛梅 | Medicine composition for treating premature ovarian failure |
-
2020
- 2020-10-26 CN CN202011159678.6A patent/CN112089822A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102688478A (en) * | 2012-06-09 | 2012-09-26 | 东莞市照燕生物科技有限公司 | Injection for treating premature ovarian failure |
| CN104027339A (en) * | 2014-06-12 | 2014-09-10 | 王淑芳 | Vitamin composition and application thereof in regulating ovarian function |
| CN105213467A (en) * | 2015-10-30 | 2016-01-06 | 张英杰 | A kind of Chinese medicine composition for the treatment of premature ovarian failure |
| CN105616561A (en) * | 2016-03-10 | 2016-06-01 | 王盛梅 | Medicine composition for treating premature ovarian failure |
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Application publication date: 20201218 |