CN112076359A - Plasma adsorption filtering device for treating kidney stone and filtering method thereof - Google Patents

Plasma adsorption filtering device for treating kidney stone and filtering method thereof Download PDF

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CN112076359A
CN112076359A CN202010960922.2A CN202010960922A CN112076359A CN 112076359 A CN112076359 A CN 112076359A CN 202010960922 A CN202010960922 A CN 202010960922A CN 112076359 A CN112076359 A CN 112076359A
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filter plate
filter
blood
fixing seat
membrane
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CN112076359B (en
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顾凌巍
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Jiangsu Qirui Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0407—Additives and treatments of the filtering material comprising particulate additives, e.g. adsorbents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0414—Surface modifiers, e.g. comprising ion exchange groups

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
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  • External Artificial Organs (AREA)

Abstract

The invention provides a plasma adsorption and filtration device for treating kidney stones, which comprises an upper cover, a lower cover and a filter element, wherein the filter element is arranged between the upper cover and the lower cover, the filter element comprises a first filter plate and a second filter plate, the first filter plate is formed by laminating glass fiber membrane materials subjected to surface modification by oxalate decarboxylase, the second filter plate comprises a microporous filter membrane, and the second filter plate is arranged at the bottom of the first filter plate.

Description

Plasma adsorption filtering device for treating kidney stone and filtering method thereof
Technical Field
The invention belongs to the technical field of filtration, and particularly relates to a plasma adsorption and filtration device for treating kidney stones and a filtration method thereof.
Background
The kidney stone is caused by some factors to increase the concentration or reduce the solubility of crystal substances in urine, and the crystal substances are in a supersaturated state, separated out and locally grown and accumulated to finally form the stone. Renal calculus can cause colic, malignancy, vomiting, dysphoria, abdominal distention, hematuria, etc. in the waist and abdomen. If combined with urinary tract infection, aversion to cold and fever may occur. Acute renal colic often causes patients to have intolerable pain. Calcium oxalate calculus is the most common (more than 80 percent) main disease cause of kidney calculus, and is characterized in that oxalic acid is accumulated excessively in a body, calcium oxalate is combined with calcium ions to form calcium oxalate, and the calcium oxalate is separated out from the kidney to form calcium oxalate calculus, so that a series of clinical symptoms are caused. From the pathophysiology perspective, the control of oxalic acid controls most of the causes of kidney stones.
Currently, plasmapheresis is the separation of patient plasma by a plasma separator or centrifuge, followed by discarding and subsequent replenishment of plasma substitutes. However, when the plasma of other people is supplemented, the situation of insufficient plasma stock is easily met, or the problem of infection caused by inputting the plasma of other people is easily solved, so that the treatment is delayed and the infection is easy to occur.
Disclosure of Invention
The invention provides a plasma adsorption and filtration device for treating kidney stone and a filtration method thereof, which can relieve systemic inflammatory reaction of a patient and reduce the risk of infection caused by inputting other human plasma.
The technical scheme of the invention is realized as follows: the utility model provides a plasma adsorption and filtration device for kidney stone treatment, includes upper cover, lower cover and filter core, and the filter core sets up between upper cover and lower cover, and the filter core includes first filter and second filter, and first filter is by range upon range of the constitution of glass fiber membrane material through oxalate decarboxylase surface modification, and the second filter includes microfiltration membrane, and the second filter sets up in the bottom of first filter.
As a preferred embodiment, the method of manufacturing the first filter plate includes the steps of:
step 1, weighing a small amount of glass fiber filter membrane, placing the glass fiber filter membrane in a muffle furnace, roasting the glass fiber filter membrane for 2 hours at the temperature of 300-500 ℃, taking out the glass fiber filter membrane, cooling the glass fiber filter membrane, and placing the glass fiber filter membrane to room temperature to obtain a substance A;
step 2, flatly paving the substance A in a glass reaction vessel, putting glutaraldehyde solution into the glass reaction vessel containing the substance A, oscillating at the constant temperature of 30 ℃ for 2 hours, taking out and drying at 60 ℃ to obtain a substance B;
step 3, dissolving the oxalate decarboxylase freeze-dried powder in purified water, and oscillating for 30min in a constant-temperature oscillator to obtain an oxalate decarboxylase solution;
and 4, flatly paving the substance B in a glass reaction vessel, slowly pouring the oxalate decarboxylase solution into the glass reaction vessel containing the substance B, soaking the substance A, oscillating for 2min in a constant-temperature oscillator, taking out to obtain glass fibers with the surfaces modified by the oxalate decarboxylase, laminating the glass fibers with the surfaces modified by multiple layers of the oxalate decarboxylase to obtain a first filter plate, and drying at normal temperature for later use.
As a preferred embodiment, the solubility of the glutaraldehyde solution in step 2 is 1.0%, and the volume of the glutaraldehyde solution is 100 ml.
As a preferred embodiment, the oxalate decarboxylase freeze-dried powder in step 3 is added in a gram amount of 5-10mg, and the volume of purified water is 30 ml.
In a preferred embodiment, the first filter plate consists of a stack of 1-30 layers of membrane material and the second filter plate consists of a stack of 1-3 layers of microporous filter membranes.
In a preferred embodiment, the glass fibers have a diameter of 5 to 20cm and the microfiltration membrane has a diameter of 5 to 20 cm.
As a preferred embodiment, the bottom of the filter element is provided with a filter plate fixing seat, the filter plate fixing seat is arranged in a cylindrical shape with an upward opening, the bottom of the filter plate fixing seat is provided with a plurality of through holes, and the first filter plate and the second filter plate are placed in the filter plate fixing seat.
In a preferred embodiment, a base is arranged in the lower cover, the base is sleeved outside the filter plate fixing seat, and the base and the filter plate fixing seat are clamped with each other.
In a preferred embodiment, the top of the upper cover is provided with a blood transfusion port and an air exhaust port, and the bottom of the lower cover is provided with a blood outlet port.
A filtering method of a plasma adsorption filtering device for kidney stone treatment comprises the following steps:
step 1, firstly placing a second filter plate into a filter plate fixing seat, then placing a first filter plate into the filter plate fixing seat, placing the first filter plate at the top of the second filter plate, placing the filter plate fixing seat into a lower cover, clamping the filter plate fixing seat and a base, covering an upper cover at the top of the lower cover, and fixing the upper cover and the lower cover;
step 2, leading the blood of the patient into the filtering device through the blood transfusion port, leading the blood of the patient into the first filtering plate through the upper cover, and reducing the oxalic acid deposition in the blood of the patient by the first filtering plate under the action of oxalate decarboxylase;
and 3, the blood filtered by the first filter plate enters the second filter plate, the macromolecular substances in the blood of the patient at the moment are filtered by the microporous filter membrane, the filtered blood of the patient is purified, and the purified blood of the patient can be conveyed back to the body of the patient.
After the technical scheme is adopted, the invention has the beneficial effects that:
1. the invention can reduce the concentration of oxalic acid by the reaction of oxalate decarboxylase immobilized on the surface of the glass fiber and oxalic acid after treatment and the oxalate decarboxylase catalyzes the decomposition of oxalic acid. Immediately and greatly reduces the oxalic acid index in the body of a patient, reduces the accumulation of oxalic acid in the body, relieves the stroke of calcium oxalate calculus and blocks the process of renal calculus. Preventing renal calculus.
2. The invention is used for pure physical therapy when purifying the plasma, the patient can not lose the plasma, the purified plasma can be returned to the patient body, other plasma is not needed to be additionally input, and the risk of infection is avoided.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.
FIG. 1 is a schematic view of the structure of a filter device according to the present invention
In the figure, 1-upper cover; 2-lower cover; 12-bleeding outlet; 13-blood transfusion port; 9-an exhaust port; 6-a first filter plate; 7-a second filter plate; 8-filter plate fixing seat; 15-a through port; 14-base.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
As shown in figure 1, a plasma adsorption and filtration device for kidney stone treatment comprises an upper cover, a lower cover and a filter element, wherein the filter element is arranged between the upper cover and the lower cover, the filter element comprises a first filter plate and a second filter plate, the first filter plate is formed by laminating glass fiber membrane materials subjected to surface modification by oxalate decarboxylase, the second filter plate comprises a microfiltration membrane, and the second filter plate is arranged at the bottom of the first filter plate.
The manufacturing method of the first filter plate comprises the following steps:
step 1, weighing a 0.2mm glass fiber filter membrane, placing the glass fiber filter membrane in a muffle furnace, roasting the glass fiber filter membrane for 2 hours at the temperature of 300-500 ℃, taking out the glass fiber filter membrane, cooling the glass fiber filter membrane, and placing the glass fiber filter membrane to room temperature to obtain a substance A, wherein the step is used for activating the surface of the glass fiber and removing impurities.
Step 2, flatly paving the substance A in a glass reaction vessel, putting glutaraldehyde solution into the glass reaction vessel containing the substance A, oscillating at the constant temperature of 30 ℃ for 2 hours, taking out and drying at 60 ℃ to obtain a substance B;
step 3, dissolving the oxalate decarboxylase freeze-dried powder in purified water, and oscillating for 30min in a constant-temperature oscillator to obtain an oxalate decarboxylase solution;
and 4, flatly paving the substance B in a glass reaction vessel, slowly pouring the oxalate decarboxylase solution into the glass reaction vessel containing the substance B, soaking the substance A, oscillating for 2min in a constant-temperature oscillator, taking out to obtain glass fibers with the surfaces modified by the oxalate decarboxylase, laminating the glass fibers with the surfaces modified by multiple layers of oxalate decarboxylase to obtain a first filter plate, and drying at normal temperature for later use, wherein the step is used for enzyme crosslinking to form the immobilized enzyme. The two aldehyde groups of glutaraldehyde and the amino group of oxalate decarboxylase form Schiff base (-N ═ C-), which are connected by a five-carbon bridge, and the oxalate decarboxylase is fixed on the surface of the glass fiber.
The solubility of the glutaraldehyde solution was 1.0%, and the volume of the glutaraldehyde solution was 100 ml. The oxalate decarboxylase freeze-dried powder is added with 5-10mg in grams, and the volume of the purified water is 30 ml.
The first filter plate is formed by laminating 1-30 layers of membrane materials, and the second filter plate is formed by laminating 1-3 layers of microporous filter membranes. The diameter of the glass fiber is 5-20cm, and the diameter of the microporous filtering membrane is 5-20 cm.
The bottom of filter core is provided with the filter plate fixing base, and the filter plate fixing base is the ascending cylinder type setting of opening, and the bottom of filter plate fixing base is provided with a plurality of clearing holes, first filter plate and second filter plate are placed in the filter plate fixing base.
The lower cover is internally provided with a base which is sleeved outside the filter plate fixing seat, and the base is clamped with the filter plate fixing seat. The top of upper cover is provided with transfusion mouth and gas vent, the bottom of lower cover is provided with the hemorrhage mouth.
The invention utilizes a modification method to realize the following reaction processes:
Figure BDA0002680524670000051
a filtering method of a plasma adsorption filtering device for kidney stone treatment comprises the following steps:
step 1, firstly placing a second filter plate into a filter plate fixing seat, then placing a first filter plate into the filter plate fixing seat, placing the first filter plate at the top of the second filter plate, placing the filter plate fixing seat into a lower cover, clamping the filter plate fixing seat and a base, covering an upper cover at the top of the lower cover, and fixing the upper cover and the lower cover;
step 2, leading the blood of the patient into the filtering device through the blood transfusion port, leading the blood of the patient into the first filtering plate through the upper cover, and reducing the oxalic acid deposition in the blood of the patient by the first filtering plate under the action of oxalate decarboxylase;
and 3, the blood filtered by the first filter plate enters the second filter plate, the macromolecular substances in the blood of the patient at the moment are filtered by the microporous filter membrane, the filtered blood of the patient is purified, and the purified blood of the patient can be conveyed back to the body of the patient.
The blood of a patient passes through a filter with the modified first filter plate, and the oxalic acid value content in the blood of the patient before and after passing through the filter is measured by adopting a method of GB1626-88 national standard.
The filtration experimental data of the filtration apparatus after mounting the first filter plate and the second filter plate are shown in the following table:
Figure BDA0002680524670000052
Figure BDA0002680524670000061
as shown in the table above, through the modification of the first filter plate, the first filter plate and the second filter plate after installation have obvious filtering effect on blood, and the oxalic acid value content in the filtered blood is obviously reduced, namely the oxalic acid index in the body of a patient is greatly reduced, the oxalic acid accumulation in the human body is reduced, the stroke of calcium oxalate calculus is relieved, and the kidney calculus process is blocked.
Meanwhile, the invention also performs experiments on the material selection of the first filter plate, and the data are shown in the following table:
Figure BDA0002680524670000062
as the polytetrafluoroethylene is a commonly used material for filtration, as shown in the table above, the invention selects the glass fiber with better and obvious filtration effect as the final filtration material through the comparative observation of the filtration effect of the glass fiber and the polytetrafluoroethylene.
In the description of the present invention, it is to be understood that the terms "longitudinal", "lateral", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used merely for convenience of description and for simplicity of description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed in a particular orientation, and be operated, and thus, are not to be construed as limiting the present invention. In the description of the present invention, unless otherwise specified and limited, it is to be noted that the terms "mounted," "connected," and "connected" are to be interpreted broadly, and may be, for example, a mechanical connection or an electrical connection, a communication between two elements, a direct connection, or an indirect connection via an intermediate medium, and specific meanings of the terms may be understood by those skilled in the art according to specific situations.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1. The utility model provides a plasma adsorption and filtration device for kidney stone treatment which characterized in that, includes upper cover, lower cover and filter core, the filter core sets up between upper cover and lower cover, the filter core includes first filter and second filter, first filter is by range upon range of the constitution of glass fiber membrane material through oxalate decarboxylase surface modification, the second filter includes microfiltration membrane, the second filter sets up in the bottom of first filter.
2. The plasma adsorbing and filtering device for kidney stone treatment according to claim 1, wherein the manufacturing method of the first filter plate comprises the following steps:
step 1, weighing a small amount of glass fiber filter membrane, placing the glass fiber filter membrane in a muffle furnace, roasting the glass fiber filter membrane for 2 hours at the temperature of 300-500 ℃, taking out the glass fiber filter membrane, cooling the glass fiber filter membrane, and placing the glass fiber filter membrane to room temperature to obtain a substance A;
step 2, flatly paving the substance A in a glass reaction vessel, putting glutaraldehyde solution into the glass reaction vessel containing the substance A, oscillating at the constant temperature of 30 ℃ for 2 hours, taking out and drying at 60 ℃ to obtain a substance B;
step 3, dissolving the oxalate decarboxylase freeze-dried powder in purified water, and oscillating for 30min in a constant-temperature oscillator to obtain an oxalate decarboxylase solution;
and 4, flatly paving the substance B in a glass reaction vessel, slowly pouring the oxalate decarboxylase solution into the glass reaction vessel containing the substance B, soaking the substance A, oscillating for 2min in a constant-temperature oscillator, taking out to obtain glass fibers with the surfaces modified by the oxalate decarboxylase, laminating the glass fibers with the surfaces modified by multiple layers of the oxalate decarboxylase to obtain a first filter plate, and drying at normal temperature for later use.
3. The plasma adsorbing and filtering device for kidney stone treatment according to claim 2, wherein the solubility of the glutaraldehyde solution in step 2 is 1.0%, and the volume of the glutaraldehyde solution is 100 ml.
4. The plasma adsorbing and filtering device for treating kidney stone as recited in claim 2, wherein the ratio of the adding mass of oxalate decarboxylase lyophilized powder to the adding mass of purified water in step 3 is 1:6-1: 3.
5. The plasma adsorbing and filtering device for kidney stone treatment according to claim 2, wherein the first filter plate is composed of 1-30 layers of membrane material stack, and the second filter plate is composed of 1-3 layers of microporous filter membrane stack.
6. The plasma adsorbing and filtering device for kidney stone treatment according to claim 5, wherein the diameter of the glass fiber is 5-20cm, and the diameter of the micro-porous filtering membrane is 5-20 cm.
7. The plasma adsorption and filtration device for kidney stone treatment as claimed in claim 2, wherein the bottom of the filter element is provided with a filter plate fixing seat, the filter plate fixing seat is arranged in a cylinder shape with an upward opening, the bottom of the filter plate fixing seat is provided with a plurality of through holes, and the first filter plate and the second filter plate are placed in the filter plate fixing seat.
8. The plasma adsorbing and filtering device for treating kidney stone according to claim 7, wherein the lower cover is provided with a base inside, the base is sleeved outside the filter plate fixing seat, and the base and the filter plate fixing seat are clamped with each other.
9. The plasma adsorbing and filtering device for kidney stone treatment as recited in claim 1, wherein the top of the upper cover is provided with a blood transfusion port and an air exhaust port, and the bottom of the lower cover is provided with a blood outlet port.
10. A filtering method of a plasma adsorption filtering device for treating kidney stones is characterized by comprising the following steps:
step 1, firstly placing a second filter plate into a filter plate fixing seat, then placing a first filter plate into the filter plate fixing seat, placing the first filter plate at the top of the second filter plate, placing the filter plate fixing seat into a lower cover, clamping the filter plate fixing seat and a base, covering an upper cover at the top of the lower cover, and fixing the upper cover and the lower cover;
step 2, leading the blood of the patient into the filtering device through the blood transfusion port, leading the blood of the patient into the first filtering plate through the upper cover, and reducing the oxalic acid deposition in the blood of the patient by the first filtering plate under the action of oxalate decarboxylase;
and 3, the blood filtered by the first filter plate enters the second filter plate, the macromolecular substances in the blood of the patient at the moment are filtered by the microporous filter membrane, the filtered blood of the patient is purified, and the purified blood of the patient can be conveyed back to the body of the patient.
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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279827A (en) * 1991-01-16 1994-01-18 Allegheny-Singer Research Institute Extract and pharmaceutical composition for treatment of calcium oxalate stone disease and viral infections
US6413778B1 (en) * 1999-01-21 2002-07-02 Idexx Laboratories Methods for the detection and identification of crystals in biological fluids
US20080038246A1 (en) * 2006-08-02 2008-02-14 Altus Pharmaceuticals Inc. Crystallized Oxalate Decarboxylase And Methods Of Use
US20130330760A1 (en) * 2011-02-07 2013-12-12 University Of Florida Research Foundation Compositions and methods for monitoring oxalate
CN106540344A (en) * 2016-12-23 2017-03-29 上海江夏血液技术有限公司 For treating the plasma filtering device and method of acute cerebral infarction
CN111419786A (en) * 2019-01-09 2020-07-17 周定兰 Composition for inhibiting or dissolving calcium oxalate calculus and preparation method and application thereof
CN112076535A (en) * 2020-09-09 2020-12-15 江苏恰瑞生物科技有限公司 Biological enzyme-linked filter medium and preparation method thereof

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5279827A (en) * 1991-01-16 1994-01-18 Allegheny-Singer Research Institute Extract and pharmaceutical composition for treatment of calcium oxalate stone disease and viral infections
US6413778B1 (en) * 1999-01-21 2002-07-02 Idexx Laboratories Methods for the detection and identification of crystals in biological fluids
US20080038246A1 (en) * 2006-08-02 2008-02-14 Altus Pharmaceuticals Inc. Crystallized Oxalate Decarboxylase And Methods Of Use
US20130330760A1 (en) * 2011-02-07 2013-12-12 University Of Florida Research Foundation Compositions and methods for monitoring oxalate
CN106540344A (en) * 2016-12-23 2017-03-29 上海江夏血液技术有限公司 For treating the plasma filtering device and method of acute cerebral infarction
CN111419786A (en) * 2019-01-09 2020-07-17 周定兰 Composition for inhibiting or dissolving calcium oxalate calculus and preparation method and application thereof
CN112076535A (en) * 2020-09-09 2020-12-15 江苏恰瑞生物科技有限公司 Biological enzyme-linked filter medium and preparation method thereof

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