CN112068302B - Pathological section microscopic detection device capable of reducing pollution - Google Patents

Pathological section microscopic detection device capable of reducing pollution Download PDF

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Publication number
CN112068302B
CN112068302B CN202010996101.4A CN202010996101A CN112068302B CN 112068302 B CN112068302 B CN 112068302B CN 202010996101 A CN202010996101 A CN 202010996101A CN 112068302 B CN112068302 B CN 112068302B
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China
Prior art keywords
slide
microscope
objective lens
coarse
focusing
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CN202010996101.4A
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CN112068302A (en
Inventor
尹秀花
滕文君
刘晓岚
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Shandong University of Traditional Chinese Medicine
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Shandong University of Traditional Chinese Medicine
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Publication of CN112068302A publication Critical patent/CN112068302A/en
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    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/34Microscope slides, e.g. mounting specimens on microscope slides
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/0004Microscopes specially adapted for specific applications
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/24Base structure
    • G02B21/241Devices for focusing
    • G02B21/242Devices for focusing with coarse and fine adjustment mechanism
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/32Micromanipulators structurally combined with microscopes
    • GPHYSICS
    • G02OPTICS
    • G02BOPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00Microscopes
    • G02B21/36Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements

Abstract

The invention belongs to the technical field of medical detection equipment, and particularly relates to a pathological section microscopic detection device capable of reducing pollution. The microscope comprises a microscope body for microscopic detection of pathological sections; a holder for placement near an objective lens of the microscope body; the transport rail is arranged on the bracket and is parallel to the objective table of the microscope body; the slide glass bearing frames are arranged on the conveying track and can move to be right above the light transmission holes between the objective lens and the objective table of the microscope body along the conveying track; a drive device mounted on the slide carrier for driving the slide carrier to move along the transport track; and the controller is connected with the driving device and used for controlling the driving device to work. In the process of detecting pathological sections by using the device provided by the invention, the contact times of an operator and a microscope can be effectively reduced, and the microscope pollution is reduced.

Description

Pathological section microscopic detection device capable of reducing pollution
Technical Field
The invention belongs to the technical field of medical detection equipment, and particularly relates to a pathological section microscopic detection device capable of reducing pollution.
Background
Pathological section refers to pathological section prepared by taking pathological tissue with a certain size and adopting a pathological histology method. The diseased tissue is typically embedded in paraffin blocks, sectioned with a microtome, stained with hematoxylin-eosin, and examined further with a microscope. And finally, carrying out pathological diagnosis according to the occurrence and development processes of the pathological changes.
In the existing medical experiment process, corresponding pathological sections are prepared according to requirements, then manual observation is carried out by using a microscope, the objective table can only be used for placing one glass slide at a time, the glass slide is required to be replaced continuously, and the focal length of the microscope is adjusted so as to conveniently finish detection and observation of more sample quantities. However, the times of contacting the hand with the microscope are very large in the process, and reagents such as dyes and the like stained on the hand in the experimental process easily cause microscope pollution. It is therefore desirable to develop a microscope viewing device that can reduce the number of contacts.
Disclosure of Invention
In order to solve the technical problems, the invention provides a pathological section microscopic detection device capable of reducing pollution.
The invention aims to provide a pathological section microscopic detection device capable of reducing pollution, which comprises a microscope body, wherein the microscope body comprises an objective lens, an objective table, a fine focusing spiral and a coarse focusing spiral, and also comprises,
a holder for placement near an objective lens of the microscope body;
a transport rail mounted on the holder in parallel with the stage, a portion of the transport rail being positioned for placement between the objective lens and the light passing aperture of the stage;
a plurality of slide carriers which are arranged on the transportation rail and can move along the transportation rail to be positioned right above the light transmission hole between the objective lens and the objective table;
a drive device mounted on the slide carrier for driving the slide carrier to move along the transport track;
and the controller is connected with the driving device and used for controlling the driving device to work.
Preferably, in the pathological section microscopic detection device capable of reducing pollution, the slide bearing frame is a ring frame or a U-shaped frame, and the bottom of the slide bearing frame can be magnetically attracted with the objective table.
Preferably, in the pathological section microscopic detection device capable of reducing pollution, the inner side of the annular frame or the U-shaped frame is in a step shape, and the glass slide can be placed on the step shape.
Preferably, the above-mentioned pathological section microscopic detection device capable of reducing pollution further comprises a spring piece for fixing the slide, and the spring piece is arranged at the side edge of the slide bearing frame.
Preferably, the above-mentioned pathological section microscopic detection device capable of reducing pollution, wherein the transportation track comprises two annular tracks concentrically arranged or two straight tracks arranged in parallel.
Preferably, the device for detecting pathological section microscopically can reduce pollution, and the driving device is a roller with a roller rotating motor; the rollers are used for moving along the conveying track;
the drive means is mounted on the slide carrier at the forefront of the array or on each of the slide carriers.
Preferably, the pathological section microscopic detection device capable of reducing pollution further comprises,
a fine focus bidirectional rotary motor mounted on the fine focus spiral;
a coarse-focus bidirectional rotary motor mounted on the coarse-focus screw;
the controller is respectively and electrically connected with the fine-focusing bidirectional rotary motor and the coarse-focusing bidirectional rotary motor and is used for controlling the two to work.
Preferably, the above pathological section microscopic detection device capable of reducing pollution further comprises two transverse grooves with openings on the upper surface, wherein the transverse grooves are arranged on the objective table and are respectively positioned on two sides of the light passing hole, and the transverse grooves are correspondingly connected with the transportation rail in a penetrating way.
Compared with the prior art, the pathological section microscopic detection device capable of reducing pollution has the following beneficial effects:
1. the invention uses the camera to shoot the picture to be microscopically detected, places the slide glass sample and the like to be microscopically detected on the slide glass bearing frames, arranges the slide glass bearing frames on the transportation track, controls the corresponding roller rotating motor to work through the switch of the switch panel, drives the slide glass to move to be positioned right above the light transmission hole, and controls the forward and reverse rotation of the coarse-focus spiral or the fine-focus spiral, so that the clear picture is displayed on the computer display. In the process of detecting pathological sections by using the device provided by the invention, the hand of an operator only contacts with the easily-cleaned thick and thin standard Jiao Luoxuan, and the hand does not contact with the objective table and the difficultly-cleaned objective lens, so that the contact times of the operator and a microscope can be effectively reduced, and the pollution of the microscope can be effectively reduced.
2. The invention can continuously observe a plurality of glass slides at one time, does not need to change the glass slides midway, does not need to frequently adjust the fine focusing spiral and the coarse focusing spiral, and has high detection efficiency, high speed and simple operation.
3. According to the invention, the fine-focusing bidirectional rotary motor and the coarse-focusing bidirectional rotary motor are arranged, and after the corresponding fine-focusing spiral and the coarse-focusing spiral are controlled to rotate forward and backward through the switch of the switch panel, the hands of an operator are not contacted with a microscope in the detection process, so that the pollution probability of the microscope is greatly reduced.
Drawings
FIG. 1 is a schematic diagram of a conventional microscope;
FIG. 2 is a schematic diagram of a device for microscopic examination of pathological sections, which can reduce pollution;
FIG. 3 is a schematic illustration of the attachment of the stage to the slide carrier of the present invention;
fig. 4 is a schematic view of the connection of the transport rail to the slide carrier of the present invention.
Detailed Description
In order that those skilled in the art will better understand the technical scheme of the present invention, the present invention will be further described with reference to specific embodiments and drawings.
Example 1
The invention provides a pathological section microscopic detection device capable of reducing pollution, which is shown in fig. 1-4, and comprises a microscope body 1, wherein the microscope body 1 adopts a microscope structure capable of being provided with a camera in the prior art, and the microscope body comprises an ocular lens 11, a lens cone 12, a converter 13, an objective lens 14, an objective table 2, a light shield, a reflector 15, a lens seat 16, a lens column 17, a lens arm 18, a fine focusing spiral 3 and a coarse focusing spiral 4. The microscope body 1 has a function of detecting and observing pathological sections. The microscope body 1 further comprises a camera which can image pathological sections, and the connection mode of the camera and the microscope body 1 is just described by referring to the camera installation of the prior art. And transmitting the picture shot by the camera to a computer display for displaying.
The invention also comprises a slide conveying device, which comprises a bracket 5, wherein the bracket 5 is used for being placed near the objective lens 14 of the microscope body 1 to play a role in bearing. The support 5 is provided with a transport rail 6 parallel to the objective table 2, part of the transport rail 6 is used for being placed between the objective lens 14 and the light transmission hole 21 of the objective table 2, other parts are used for being placed on the side of the microscope body 1, at least two slide bearing frames 7 are placed on the transport rail 6, the slide bearing frames 7 can move along the transport rail 6, each slide bearing frame 7 can move to the position right above the light transmission hole 21 between the objective lens 14 and the objective table 2, the slide bearing frames 7 are used for placing dyed pathological sections, the pathological sections can be tiled on the slide 8, then the slide 8 is placed on the slide bearing frames 7, and the slide 8 can move to the position between the objective lens 14 and the objective table 2 along with the slide bearing frames 7 and right above the light transmission hole 21 so as to be convenient for microscopic observation.
The slide glass bearing frame 7 is an annular frame or a U-shaped frame, and when the slide glass bearing frame 7 moves to be positioned between the objective lens 14 and the objective table 2 and right above the light passing hole 21, the arrangement of the annular frame or the U-shaped frame enables no other shielding object above the light passing hole 21, so that microscopic detection and observation of samples are facilitated. The inside of the ring-shaped rack or the U-shaped rack is in a stepped shape, and the slide glass 8 can be placed on the steps of the stepped shape. Preferably, in order to improve the stability of the slide 8, it is mounted on a stepped shape of the ring frame with the upper surface of the slide 8 flush with the upper surface of the slide carrier 7. Preferably, in order to further improve the stability of the slide 8, the slide carrier 7 is provided with elastic pieces 71 on the side edges thereof, which can be sprung upward, and the slide 8 is fixed by applying pressure to the elastic pieces 71.
Each slide carrier 7 is provided with a drive means for driving it along the transport track 6. The driving device is a roller 61 with a roller rotating motor, the roller 61 is a universal wheel, the transporting rail 6 comprises two annular rails which are concentrically arranged, one end of the transporting rail 6 is used for being placed between the objective lens 14 and the objective table 2, and the other end of the transporting rail is used for being placed beside the microscope body 1. The bottom of the slide carrier 7 is provided with four rollers 61, two rollers 61 are respectively arranged on two sides of the bottom, wherein two rollers 61 on one side can move along the outer annular track, and two rollers 61 on the other side can move along the inner annular track.
The bottom of the slide carrier 7 is provided with a magnet that can attract the magnetic member provided on the stage 2. When the roller rotating motor is started, the power of the roller rotating motor can overcome the attractive force to move the roller 61.
The mirror base 16 is provided with a controller which is in wireless connection with the roller rotating motor, and the controller is also connected with a switch panel through an electric wire. The switch panel is provided with corresponding name switches for controlling the work of the rotary motors of the rolling wheels.
When the device is used, a picture to be microscopically detected is shot by using a camera, the coarse focusing screw 4 is controlled to enable the objective lens 14 to be far away from the objective table 2, then an operator places the support 5 near the objective lens 14 of the microscope body 1, part of the structure of the conveying track 6 is positioned between the objective lens 14 and the objective table 2, the rest part of the structure is positioned at the side of the microscope body 1, a slide sample and the like to be microscopically detected are placed on the slide bearing frame 7, then a plurality of slide bearing frames 7 are arranged on the conveying track 6, each roller rotating motor corresponds to one switch, the operator controls the corresponding roller rotating motor to work through the switch panel, drives the slide 8 corresponding to the roller rotating motor to be positioned right above the light-transmitting hole 21, then controls the coarse focusing screw 4 or the fine focusing screw 3 to rotate forwardly and reversely, so that a clear picture is displayed on a computer display, and then the record is photographed. In the whole detection process, the operator hand is only in contact with the coarse focusing spiral 4 or the fine focusing spiral 3 which are easy to clean, is not in contact with the objective table and the objective lens 14 which is difficult to clean, so that microscope pollution can be effectively reduced, a plurality of glass slides 8 can be continuously observed once, the glass slides 8 do not need to be replaced midway, and the detection device is simple to operate and high in efficiency.
After the position of the first slide carrier 7 is adjusted, a distance is reserved between the objective lens 14 and the objective table 2, and the next slide carrier 7 pushes the previous slide carrier 7 to move forward along the conveying track, so that the next slide 8 can be detected and observed only by controlling the objective slide 8 to be observed to move to a specific position. And because the position of the ocular 11 is still motionless, the microscopic picture is still clearer, only fine adjustment is needed, the problem that the fine focusing spiral 3 and the coarse focusing spiral 4 are frequently adjusted due to frequent manual replacement of the glass slide 8 is avoided, and the detection efficiency is improved. The slide carrier 7 is transported and moved in the horizontal plane of the transport rail 6, even if the distance between the objective lens 14 and the objective table 2 is small, the distance between the objective lens 14 and the objective table 2 is only required to be finely adjusted, so that the slide carrier 7 can obtain clear images through the distance, the adjustment amplitude is small, and the adjustment speed is high.
Example 2
The transporting rail 6 comprises two straight rails which are arranged in parallel, the middle part of the transporting rail 6 is used for being placed between the objective lens 14 and the objective table 2, and other parts are used for being placed on two sides of the microscope body 1. The driving device is a moving wheel with a roller rotating motor, four moving wheels are arranged at the bottom of the slide bearing frame 7, two moving wheels are respectively arranged at the bottom of the slide bearing frame, and the moving wheels can move along a straight track on the same side of the slide bearing frame.
The remaining structure and operation principle of embodiment 2 are the same as those of embodiment 1.
Example 3
The structure and working principle of the embodiment 3 are basically the same as those of the embodiment 1, except that only the roller 61 of the slide carrier 7 positioned at the forefront of the queue is provided with a roller rotating motor, the rest slide carriers 7 are detachably connected together in sequence through hooks, and the controller is also connected with a switch for controlling the roller rotating motor through an electric wire. When the next observation object needs to be replaced, the forefront slide carrier 7 is controlled to move, and the rear slide carrier 7 can be driven to move.
Example 4
In order to further improve the efficiency and avoid pollution, the fine focusing spiral 3 is provided with a fine focusing bidirectional rotating motor 31 for controlling the rotation of the fine focusing spiral, the coarse focusing spiral 4 is provided with a coarse focusing bidirectional rotating motor 41 for controlling the rotation of the coarse focusing spiral, the controller is respectively electrically connected with the fine focusing bidirectional rotating motor 31 and the coarse focusing bidirectional rotating motor 41, and the switch panel is provided with corresponding name switches for respectively controlling the operation of the fine focusing bidirectional rotating motor 31, the coarse focusing bidirectional rotating motor 41 and the roller rotating motors. The coarse focusing helix 4 needs to be controlled by a switch panel when the objective lens 14 is moved away from the stage 2. When a clear picture is required to be displayed on the computer display, the switch panel is used to control the forward and reverse rotation of the coarse-focus bi-directional rotating motor 41 or the fine-focus bi-directional rotating motor 31. The remaining structure and operation principle of embodiment 4 are the same as those of embodiment 1.
In the embodiment, the fine focusing bidirectional rotary motor 31 and the coarse focusing bidirectional rotary motor 41 are arranged, and the corresponding fine focusing spiral 3 and coarse focusing spiral 4 are controlled to rotate forward and backward through the switch panel switch, so that the hands of an operator are not contacted with a microscope at all, and the pollution probability of the microscope is greatly reduced.
Example 5
In order to improve the stability of the device, transverse grooves 22 with an open upper surface are formed on two sides of the light through hole 21 on the objective table 2, wherein one transverse groove 22 is used for passing through one rail of the conveying rail 6, and the other transverse groove 22 is used for passing through the other rail of the conveying rail 6. The surface of the transport rail 6 in contact with the transverse grooves 22 is provided with magnetic means, such as magnets. The transportation rail 6 is fixed on the object stage 2, and the stability of the device is good.
The remaining structure and operation principle of embodiment 5 are the same as those of embodiment 1.
It should be noted that, the connection relationships of the components not specifically mentioned in the present invention are all default to the prior art, and the connection relationships of the structures are not described in detail because they do not relate to the invention points and are common applications of the prior art.
It should be noted that while the preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. It is therefore intended that the following claims be interpreted as including the preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various modifications and variations can be made to the present invention without departing from the spirit or scope of the invention. Thus, it is intended that the present invention also include such modifications and alterations insofar as they come within the scope of the appended claims or the equivalents thereof.

Claims (2)

1. The pathological section microscopic detection device capable of reducing pollution comprises a microscope body (1), wherein the microscope body (1) comprises an objective lens (14), an objective table (2), a fine focusing spiral (3) and a coarse focusing spiral (4), and is characterized by further comprising,
a holder (5) for placement in the vicinity of an objective lens (14) of the microscope body (1);
a transport rail (6) mounted on the support (5) and parallel to the stage (2), part of the transport rail (6) being positioned for placement between the objective lens (14) and the light-transmitting aperture (21) of the stage (2), the transport rail (6) comprising two annular rails arranged concentrically or comprising two straight rails arranged in parallel;
a plurality of slide carriers (7) which are arranged on the conveying rail (6) and can move along the conveying rail (6) to be right above a light transmission hole (21) between the objective lens (14) and the objective table (2); the slide bearing frame (7) is an annular frame or a U-shaped frame, and the bottom of the slide bearing frame can be magnetically attracted with the objective table (2);
a driving device which is arranged on the slide carrier (7) and is used for driving the slide carrier (7) to move along the conveying track (6), wherein the driving device is a roller (61) with a roller rotating motor; the rollers (61) are used for moving along the conveying track (6);
the driving device is arranged on the slide carrier (7) at the forefront of the queue or on each slide carrier (7);
the controller is connected with the driving device and used for controlling the driving device to work;
the inner side of the annular frame or the U-shaped frame is in a step shape, and a glass slide (8) can be placed on the step shape;
also comprises a spring piece (71) for fixing the slide glass (8), which is arranged at the side edge of the slide glass bearing frame (7);
the device also comprises two transverse grooves (22) with openings on the upper surface, wherein the transverse grooves are arranged on the object stage (2) and are respectively positioned on two sides of the light transmission hole (21), and the transverse grooves (22) are correspondingly connected with the conveying track (6) in a penetrating way.
2. The apparatus for microscopic examination of pathological sections with reduced contamination according to claim 1, further comprising,
a fine focus bi-directional rotating motor (31) mounted on the fine focus screw (3);
a coarse-focus bi-directional rotating motor (41) mounted on the coarse-focus screw (4);
the controller is respectively and electrically connected with the fine-focusing bidirectional rotary motor (31) and the coarse-focusing bidirectional rotary motor (41) and is used for controlling the two to work.
CN202010996101.4A 2020-09-21 2020-09-21 Pathological section microscopic detection device capable of reducing pollution Active CN112068302B (en)

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Publication number Priority date Publication date Assignee Title
CN113572912A (en) * 2021-07-03 2021-10-29 冯浩 Remote transmission method of digital pathological section

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CN208847951U (en) * 2018-10-26 2019-05-10 赵纪龙 A kind of biomicroscope objective table

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JP2010113021A (en) * 2008-11-04 2010-05-20 Nikon Corp Microscope
CN203178562U (en) * 2013-04-16 2013-09-04 山东省立医院 Remote-control movable-type microscope workbench
CN204229044U (en) * 2014-10-22 2015-03-25 神华集团有限责任公司 A kind of microscope
CN205263391U (en) * 2016-01-04 2016-05-25 高勇 Special microscope of clinical laboratory of hospital
CN205539691U (en) * 2016-01-20 2016-08-31 陈光鑫 Multi freedom brothers microscope for microsurgery
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CN208847951U (en) * 2018-10-26 2019-05-10 赵纪龙 A kind of biomicroscope objective table

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