CN112057041B - Polarized photoacoustic imaging probe and photoacoustic imaging device - Google Patents
Polarized photoacoustic imaging probe and photoacoustic imaging device Download PDFInfo
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- CN112057041B CN112057041B CN202010790562.6A CN202010790562A CN112057041B CN 112057041 B CN112057041 B CN 112057041B CN 202010790562 A CN202010790562 A CN 202010790562A CN 112057041 B CN112057041 B CN 112057041B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
Abstract
The application relates to the technical field of photoacoustic imaging, and discloses a polarized photoacoustic imaging probe and a photoacoustic imaging device. The polarized photoacoustic imaging probe includes: a light source assembly, a polarizing device and an ultrasonic transducer; the polarization device comprises a polarization component and a polarization adjusting component, wherein the polarization component and the polarization adjusting component are arranged on a light path of the light source component, the polarization component is used for converting light emitted by the light source component into polarized light, and the polarization adjusting component is configured to adjust the polarization state of the polarized light; and the ultrasonic transducer is used for receiving the photoacoustic signal generated by the polarized light acting on the irradiated object. By the mode, the control precision of the polarization state of light can be improved, and the extraction capability of photoacoustic imaging on tissue specific information is enriched and expanded.
Description
Technical Field
The application relates to the technical field of photoacoustic imaging, in particular to a polarized photoacoustic imaging probe and a photoacoustic imaging device.
Background
In recent years, the rapidly emerging photoacoustic imaging technology provides new opportunities for imaging studies of various diseases with its unique advantages. The technology is based on a photoacoustic effect, pulsed light is used as an excitation source, acoustic signals are used as information carriers, and a group of collected signals (photoacoustic signals) are subjected to image reconstruction processing to obtain tissue internal structure information. The photoacoustic imaging technology has made a great breakthrough in the directions of brain imaging, breast cancer detection, osteoarthritis detection, blood oxygen saturation detection of blood vessels and the like. The method is a non-invasive, human-safe, low-cost and miniaturized high-precision imaging technology capable of realizing micron-scale resolution at centimeter-scale depth, and can accurately monitor the information of chemical components, tissue structures and the like in the natural state in the living tissue. Has wide application prospect in the medical application field. But photoacoustic imaging generally ignores the property of tissue to the absorption of the laser anisotropy vector and assumes the absorption coefficient of tissue as a non-directional scalar constant. It has been shown that there are many tissues in a living body whose optical absorption exhibits specific dichroism due to the order of molecular arrangement, i.e. the light absorption coefficient of the tissue is no longer a scalar constant but has anisotropic vector, which means that photons of different polarization states undergo different degrees of absorption through the tissue. Research on photoacoustic imaging using polarized light characteristics to excite tissue anisotropic absorption shows that the development of polarized light photoacoustic imaging will enable photoacoustic imaging with the ability to image object-specific with certain anisotropic vector absorption. Therefore, the study on the absorption degree of the tissues to photons with different polarization states can enrich and expand the extraction capability of the photoacoustic imaging to tissue specific information.
Disclosure of Invention
The technical problem that this application mainly solved provides a polarization optoacoustic imaging probe and optoacoustic imaging device, can improve the control accuracy of the polarization state of focusing, and then richen with the extraction ability of extension optoacoustic imaging to organizing specific information.
A technical solution adopted by the present application is to provide a polarized photoacoustic imaging probe, which includes: a light source assembly; the polarization device comprises a polarization component and a polarization adjusting component, wherein the polarization component and the polarization adjusting component are arranged on a light path of the light source component, the polarization component is used for converting light emitted by the light source component into polarized light, and the polarization adjusting component is configured to adjust the polarization state of the polarized light; and the ultrasonic transducer is used for receiving the photoacoustic signal generated by the polarized light acting on the irradiated object.
Wherein, the light source subassembly includes: a light source; and the lens assembly comprises a plurality of lenses which are arranged on the light path of the light source at intervals.
The lens assembly comprises a first plano-convex lens, a second plano-convex lens, a third plano-convex lens and a fourth plano-convex lens which are arranged in sequence from one side close to the light source; the convex surface of the first plano-convex lens faces to the side far away from the light source, the convex surface of the second plano-convex lens faces to the side far away from the light source, the convex surface of the third plano-convex lens faces to the side close to the light source, and the convex surface of the fourth plano-convex lens faces to the side close to the light source; the polarizing component and the polarization adjusting component are arranged between the third plano-convex lens and the fourth plano-convex lens, and the polarizing component is close to one side of the light source.
Wherein, polarization adjustment subassembly includes: adjusting the bracket; the delay piece is arranged on the adjusting bracket; wherein, the adjusting bracket is configured to move under the action of an external force, and the angle of the retarder is changed to adjust the polarization state of the polarized light.
The polarized photoacoustic imaging probe further comprises a first clamping assembly, and the first clamping assembly comprises a plurality of accommodating cavities for accommodating the light source assembly and the polarizing device.
The first clamping assembly comprises a first clamping shell, a second clamping shell and a third clamping shell; the first clamping shell, the second clamping shell and the third clamping shell are connected in a matched mode to form a plurality of accommodating cavities.
A first accommodating groove is formed in one side of the first end of the first clamping shell, and a first accommodating cavity is formed by the first accommodating groove and the second clamping shell and used for accommodating the light source; a second accommodating groove is formed in one side of the second end of the first clamping shell, and forms a second accommodating cavity with the third clamping shell for accommodating the lens assembly and the polarizing device; the side wall of the second end of the first clamping shell is provided with a first extension part and a second extension part, and the first extension part and the second extension part are oppositely arranged to form an accommodating space for accommodating the ultrasonic transducer; the first accommodating cavity is communicated with the second accommodating cavity, and a through hole is formed along the light path direction of the light source, so that light generated by the light source passes through the through hole.
The second accommodating groove is provided with an opening, and the adjusting support is arranged corresponding to the opening so that the part of the adjusting support is exposed through the opening.
The polarized photoacoustic imaging probe further comprises a second clamping assembly, the second clamping assembly is arranged in the accommodating space, and the second clamping assembly comprises a third accommodating cavity used for accommodating the ultrasonic transducer.
The second clamping assembly comprises a fourth clamping shell and a fifth clamping shell, and the fourth clamping shell and the fifth clamping shell are connected in a matched mode to form a third accommodating cavity.
The light path direction of the light source assembly and the detection direction of the ultrasonic transducer are intersected at a preset position, and a preset angle is formed between the light path direction and the detection direction; wherein, the preset position is the placing position of the irradiated object.
Wherein the length between the preset position and the ultrasonic transducer is 6-8 mm; or the preset angle is 35-38 degrees.
Another technical solution adopted by the present application is to provide a photoacoustic imaging apparatus, including: a photoacoustic imaging probe; the image processing device is connected with the photoacoustic imaging probe and used for controlling the work of the photoacoustic imaging probe, acquiring photoacoustic signals acquired by the photoacoustic imaging probe and forming an image based on the acquired photoacoustic signals; the photoacoustic imaging probe is the polarized photoacoustic imaging probe provided by the technical scheme.
The beneficial effect of this application is: in contrast to the state of the art, the present application provides a polarized photoacoustic imaging probe, comprising: a light source assembly; the polarization device comprises a polarization component and a polarization adjusting component, wherein the polarization component and the polarization adjusting component are arranged on a light path of the light source component, the polarization component is used for converting light emitted by the light source component into polarized light, and the polarization adjusting component is configured to adjust the polarization state of the polarized light; and the ultrasonic transducer is used for receiving the photoacoustic signal generated by the polarized light acting on the irradiated object. Through the regulation to polarization adjusting part, obtain the polarization state of the light of actual needs, improve the control accuracy to the polarization state of light, promote the stability of the polarization state of light, and then improve the extraction ability of specific information of tissue to the optoacoustic imaging.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts. Wherein:
FIG. 1 is a schematic diagram of an embodiment of a polarized photoacoustic imaging probe provided herein;
FIG. 2 is a schematic cross-sectional view of FIG. 1 provided herein;
FIG. 3 is a schematic diagram of a light source module and a polarization module provided herein;
FIG. 4 is a schematic diagram of a polarization adjustment assembly provided herein;
FIG. 5 is an exploded view of the first clamping assembly provided herein;
FIG. 6 is a schematic structural view of a first clamp housing provided herein;
FIG. 7 is a schematic illustration of a top view of the first clamp housing of FIG. 6 as provided herein;
FIG. 8 is a schematic top view of the first clamp housing of FIG. 6 provided herein;
FIG. 9 is a schematic structural view of a second clamp housing provided herein;
FIG. 10 is a schematic structural view of a third clamp housing provided herein;
FIG. 11 is a schematic illustration in plan view of the third clamp housing of FIG. 10 as provided herein;
FIG. 12 is a schematic structural view of a second clamping assembly provided herein;
FIG. 13 is a schematic structural view of the fourth clamp housing of FIG. 12 as provided herein;
FIG. 14 is a schematic structural view of the fifth clamp housing of FIG. 12 as provided herein;
FIG. 15 is a schematic top view of the fifth clamp housing of FIG. 13 as provided herein;
FIG. 16 is a schematic view of an application of a polarized photoacoustic imaging probe provided by the present application;
FIG. 17 is a schematic diagram illustrating the structure of an embodiment of a photoacoustic imaging apparatus provided by the present application;
fig. 18 is a schematic structural diagram of an embodiment of a photoacoustic imaging apparatus provided by the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application. It is to be understood that the specific embodiments described herein are merely illustrative of the application and are not limiting of the application. It should be further noted that, for the convenience of description, only some of the structures related to the present application are shown in the drawings, not all of the structures. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.
In order to solve the problem, the polarization adjusting assembly of the polarization state of the adjustable polarized light is used for adjusting the polarized light, the control precision of the polarization state of the light is improved, the stability of the polarization state of the light is improved, and the extraction capability of the photoacoustic imaging on the tissue specificity information is further improved. The detailed description is given in the following examples.
Referring to fig. 1 and fig. 2, fig. 1 is a schematic structural diagram of an embodiment of a polarized photoacoustic imaging probe provided by the present application, and fig. 2 is a schematic cross-sectional structural diagram of fig. 1. The polarized photoacoustic imaging probe comprises a first clamping assembly 11, a polarizing device 12, an ultrasonic transducer 13, a second clamping assembly 14 and a light source assembly 15.
The light source assembly 15 is configured to transmit pulsed light.
The polarization device 12 includes a polarizing component 121 and a polarization adjusting component 122. The polarizing component 121 and the polarization adjusting component 122 are disposed on the light path of the light source assembly 15. The polarizing component 121 is used for converting the light emitted from the light source assembly 15 into polarized light, and the polarization adjusting component 122 is configured to adjust the polarization state of the polarized light.
The polarizing element 121 is a polarizer, and converts light emitted from the light source assembly 15 into polarized light.
The ultrasonic transducer 13 is used for receiving photoacoustic signals generated by polarized light acting on an irradiated object. When the pulsed laser light irradiates the irradiated object, the light absorption domain of the tissue in the irradiated object will generate an ultrasonic signal, and such an ultrasonic signal generated by light excitation is called a photoacoustic signal.
It can be understood that because the polarization state of the light is adjusted based on the light outlet of the light source assembly 15, the polarization state of the light is less affected by the system, and an important guarantee is provided for the quality of the polarized light photoacoustic imaging.
In some embodiments, the ultrasound transducer 13 comprises a probe for receiving photoacoustic signals generated by polarized light acting on the irradiated object through the probe. Wherein the probe center frequency may be 15 MHZ.
In some embodiments, the probe may be a one-dimensional probe, such as a linear array probe, a convex array probe. The probe may also be a two-dimensional probe, such as an area array probe. It can be understood that the specifications of the probe are reasonably selected according to actual requirements.
In some embodiments, the light source assembly 15 includes a light source 151 and a lens assembly 152, the light source 151 is an optical fiber, the optical fiber is a multimode optical fiber, and the excitation light is coupled into the optical fiber and fixed by the first clamping assembly 11. The excitation light is pulsed light. In some embodiments, the core position of the fiber is 1.5 mm.
The lens assembly 152 includes a plurality of lenses disposed at intervals on the optical path of the light source. In some embodiments, lens assembly 152 may include two convex lenses or three convex lenses or four convex lenses or five convex lenses or six convex lenses, or the like. Through the combination among a plurality of lenses, the light generated by the light source is adjusted, so that the light spot irradiated on the irradiated object is similar to the area of the probe of the ultrasonic transducer 13, and the ultrasonic transducer 13 receives the photoacoustic signal to the maximum extent.
In some embodiments, the lens assembly 152 includes a first plano-convex lens 1521, a second plano-convex lens 1522, a third plano-convex lens 1523, and a fourth plano-convex lens 1524. The first plano-convex lens 1521, the second plano-convex lens 1522, the third plano-convex lens 1523, and the fourth plano-convex lens 1524 are sequentially disposed from the side close to the light source 151.
Specifically, referring to fig. 3, the convex surface of the first plano-convex lens 1521 faces away from the light source 151, the convex surface of the second plano-convex lens 1522 faces away from the light source, the convex surface of the third plano-convex lens 1523 faces toward the light source, and the convex surface of the fourth plano-convex lens 1524 faces toward the light source.
The polarization component 121 and the polarization adjustment component 122 are disposed between the third plano-convex lens 1523 and the fourth plano-convex lens 1524, and the polarization component 121 is close to the light source 151.
The application of the light source module 15, the polarizing module 121 and the polarization adjustment module 122 will be described.
When the light source 151 emits pulsed light, the pulsed light passes through the first plano-convex lens 1521, exits from the convex surface of the first plano-convex lens 1521 to form a beam of pulsed light polymerized in the first state, continues to pass through the second plano-convex lens 1522, exits from the convex surface of the second plano-convex lens 1522 to form a beam of pulsed light polymerized in the second state, continues to pass through the third plano-convex lens 1523, enters from the convex surface of the third plano-convex lens 1523, exits from the plane of the third plano-convex lens 1523 to form a beam of pulsed light polymerized in the third state, continues to pass through the polarization component 121 to obtain corresponding polarized light, passes through the polarization regulating component 122 to obtain polarized light in a corresponding polarization state, continues to pass through the fourth plano-convex lens 1524, enters from the convex surface 1524 of the fourth plano-convex lens 1524, exits from the plane of the fourth plano-convex lens 1524, and irradiates on an irradiated object, so as to form a light spot with an area similar to that of the ultrasound transducer 13.
Referring to fig. 4, the polarization adjustment assembly 122 includes an adjustment bracket 1221, a retardation plate 1222, and a fixing member 1223.
The delay tab 1222 is disposed on the adjusting bracket 1221. The adjusting bracket 1221 is configured to be moved by an external force to change the angle of the retarder 1222, so as to adjust the polarization state of the polarized light.
Specifically, the adjusting bracket 1221 includes a housing bracket 12211 and an adjusting member 12212. The delay piece 1222 is provided on the adjusting member 12212, and the adjusting member 12212 is provided on the housing shelf 12211. The accommodating rack 12211 is provided with scales corresponding to the angle. During the adjustment process, the degree of adjustment can be specified to obtain the polarization state of the light with the corresponding degree. Such as from 0 degrees to 360 degrees.
In some embodiments, the fixing member 1223 cooperates with the housing shelf 12211 to fix the housing shelf 12211 to the first clamping assembly 11.
In some embodiments, the retarder plate may be a half-wave plate or a full-wave plate or a quarter-wave plate.
In some embodiments, the first clamping assembly 11 includes a plurality of receiving cavities for receiving the light source assembly 15 and the polarizing device 12.
Specifically, referring to fig. 5, the first clamping assembly 11 includes a first clamping housing 111, a second clamping housing 112, and a third clamping housing 113. The first clamping shell 111, the second clamping shell 112 and the third clamping shell 113 are connected in a matching manner to form a plurality of accommodating cavities.
Referring to fig. 6 to 11, a first receiving groove is disposed at one side of the first end 1111 of the first clamping housing 111, and forms a first receiving cavity with the receiving groove 1121 of the second clamping housing 112 for receiving a light source. It will be appreciated that in some embodiments, the second clamping housing 112 and the first end 1111 of the first clamping housing 111 have corresponding through holes with corresponding threads, and the second clamping housing 112 and the first end 1111 of the first clamping housing 111 are secured to clamp the light source by using bolts to engage the threads.
A second receiving groove is formed at one side of the second end 1112 of the first holding housing 111, and forms a second receiving cavity with the third holding housing 113 for receiving the lens assembly 152 and the polarizer 12.
The sidewall of the second end 1112 of the first clamping housing 111 is provided with a first extension part 1113 and a second extension part 1114, and the first extension part 1113 and the second extension part 1114 are disposed opposite to each other to form an accommodating space for accommodating the ultrasonic transducer 13.
The first accommodating cavity is communicated with the second accommodating cavity, and a through hole is formed along the light path direction of the light source, so that light generated by the light source passes through the through hole.
Specifically, a second receiving groove is formed at one side of the second end 1112 of the first clamping housing 111, and the second receiving groove includes a plurality of sub-receiving grooves, such as the first sub-receiving groove 11121, the second sub-receiving groove 11122, the third sub-receiving groove 11123, the fourth sub-receiving groove 11124, the fifth sub-receiving groove 11125, and the sixth sub-receiving groove 11126. It can be understood that an accommodating space exists between the first sub-accommodating groove 11121 and the second sub-accommodating groove 11122. The second sub receiving groove 11122 and the third sub receiving groove 11123 have a receiving space. The third sub receiving groove 11123 and the fourth sub receiving groove 11124 form a receiving space. The fourth sub receiving groove 11124 and the fifth sub receiving groove 11125 have a receiving space. The fifth sub-receiving groove 11125 and the sixth sub-receiving groove 11126 have a receiving space. The side surfaces of the accommodating space along the light path direction are all provided with openings.
Correspondingly, the third clamping housing 113 has a seventh sub-receiving groove 11311, an eighth sub-receiving groove 11312, a ninth sub-receiving groove 11313, a tenth sub-receiving groove 11314, an eleventh sub-receiving groove 11315 and a twelfth sub-receiving groove 11316. The first sub-receiving groove 11121 and the seventh sub-receiving groove 11311 cooperate to form a receiving space for receiving the first plano-convex lens. The second sub-receiving groove 11122 and the eighth sub-receiving groove 11312 cooperate to form a receiving space for receiving the second plano-convex lens. The third sub-receiving groove 11123 and the ninth sub-receiving groove 11313 cooperate to form a receiving space for receiving the third plano-convex lens. The fourth sub-receiving groove 11124 and the tenth sub-receiving groove 11314 cooperate to form a receiving space for receiving the polarization component 121, the fifth sub-receiving groove 11125 and the eleventh sub-receiving groove 11315 cooperate to form a receiving space for receiving the polarization regulating component 122. The sixth sub-receiving groove 11126 and the twelfth sub-receiving groove 11316 cooperate to form a receiving space for receiving the fourth plano-convex lens. In some embodiments, the third clamping housing 113 and the second end 1112 of the first clamping housing 111 have corresponding through holes with corresponding threads, and the third clamping housing 113 and the second end 1112 of the first clamping housing 111 are secured together by using bolts to engage the threads to clamp the lens assembly 152 and the polarizer apparatus 12.
Specifically, the second receiving groove is provided with an opening, and the adjusting bracket in the polarization device 12 is arranged corresponding to the opening, so that part of the adjusting bracket is exposed through the opening. When the polarized photoacoustic imaging probe is used, the delay piece rotates to a specified angle along with the rotation of the adjusting support by adjusting the adjusting support exposed at the opening. When the polarized light is irradiated onto the retarder, the polarized light with a corresponding angle is emitted from the retarder.
Referring to fig. 1 and 6, the second clamping assembly 14 is disposed in the accommodating space formed by the first extension part 1113 and the second extension part 1114. The second clamping assembly 14 comprises a third receiving cavity for receiving the ultrasonic transducer 13.
Referring to fig. 12, the second clamping assembly 14 includes a fourth clamping housing 141 and a fifth clamping housing 142, and the fourth clamping housing 141 and the fifth clamping housing 142 are connected to form a third receiving cavity.
The second clamping assembly 14 is provided with a first opening 143 adapted to the probe of the ultrasonic transducer 13 and a second opening 144 adapted to the connection line of the ultrasonic transducer 13, the first opening 143 forms a channel for the probe of the ultrasonic transducer 13 to perform photoacoustic signal acquisition, and the second opening 144 is used for passing the connection line of the ultrasonic transducer 13.
Specifically, referring to fig. 13-15, the fourth clamping housing 141 includes a receiving groove 1411, and a side of the receiving groove 1411 is an opening.
The fifth clamping housing 142 includes a receiving slot 1421. The receiving groove 1411 and the receiving groove 1421 are connected in a matching manner to form a third receiving cavity for receiving the ultrasonic transducer 13. The outside of the fifth clamp housing 142 includes a first protrusion 1422 and a second protrusion 1423. The second clamping assembly 14 is disposed on the first clamping assembly 11, the first protrusion 1422 is engaged with the first groove 11127, and the second protrusion 1423 is engaged with the second groove 11128, so that the second clamping assembly 14 is fixed on the first clamping housing 111.
When the fourth and fifth clip housings 141 and 142 are mated, a first opening 143 and a second opening 144 are formed.
Referring to fig. 16, the light path direction M of the light source assembly 15 intersects the detection direction N of the ultrasonic transducer 13 at a preset position O, and a preset angle α is formed between the light path direction M and the detection direction N; the preset position O is a position where the irradiation object is placed.
The length between the preset position O and the ultrasonic transducer 13 is L. In some embodiments L is 6-8 mm; the preset angle alpha is 35-38 degrees.
It can be understood that by placing the irradiated object at a position 6-8mm away from the probe of the ultrasonic transducer 13, the area of a light spot obtained when the polarized light irradiates on the irradiated object is similar to the area of the probe of the ultrasonic transducer 13, and the distance can ensure that the energy of the polarized light is at a preset value, for example, if the distance is too far, the energy of the polarized light may be insufficient, so that the generated photoacoustic signal is not good, and the imaging effect is affected.
The preset angle is 35-38 degrees, if the preset angle is too large, part of light spots of light emitted by the light source assembly 15 directly irradiate the ultrasonic transducer 13, so that the light spots irradiated to an irradiated object are reduced, further, the photoacoustic signals received by the ultrasonic transducer 13 are insufficient, and the imaging effect is influenced. If the preset angle is too small, the distance between the O at the preset position and the probe of the ultrasonic transducer 13 is too far, so that the energy of the light spot irradiated to the irradiated object is insufficient, and further, the photoacoustic signal received by the ultrasonic transducer 13 is insufficient, and the imaging effect is affected.
In some embodiments, the outer sides of the first clamping assembly 11 and the second clamping assembly 14 of the polarized photoacoustic imaging probe shown in fig. 1 can be held by hands, so that the polarized photoacoustic imaging probe has portability and mobility relative to the related art and is suitable for samples with different sizes or with changed external dimensions.
In contrast to the state of the art, the polarized photoacoustic imaging probe of the present embodiment includes: a light source assembly; the polarization device comprises a polarization component and a polarization adjusting component, wherein the polarization component and the polarization adjusting component are arranged on a light path of the light source component, the polarization component is used for converting light emitted by the light source component into polarized light, and the polarization adjusting component is configured to adjust the polarization state of the polarized light; and the ultrasonic transducer is used for receiving the photoacoustic signal generated by the polarized light acting on the irradiated object. Through the regulation to polarization adjusting part, obtain the polarization state of the light of actual needs, improve the control accuracy to the polarization state of light, promote the stability of the polarization state of light, and then improve the extraction ability of specific information of tissue to the optoacoustic imaging.
Referring to fig. 17, fig. 17 is a schematic structural diagram of an embodiment of a photoacoustic imaging apparatus provided by the present application. The photoacoustic imaging apparatus 20 includes a photoacoustic imaging probe 21 and an image processing apparatus 22.
The image processing device 22 is connected with the photoacoustic imaging probe 21, and is used for controlling the work of the photoacoustic imaging probe, acquiring photoacoustic signals acquired by the photoacoustic imaging probe, and forming an image based on the acquired photoacoustic signals; the photoacoustic imaging probe is the polarized photoacoustic imaging probe provided by the technical scheme.
The photoacoustic imaging probe 21 is the photoacoustic imaging probe in the above embodiment. The image processing apparatus 22 may be a terminal device such as a computer.
In some embodiments, the image processing device 22 employs a DSP (Digital Signal processing) processor to Process the photoacoustic signals collected by the photoacoustic imaging probe 21 to obtain an image.
In an application scenario, referring to fig. 18, an irradiated object 30 is placed 6-8mm away from a probe of an ultrasound transducer in a photoacoustic imaging probe 21, polarized light of a preset angle and in a polarization state emitted by a light source assembly in the photoacoustic imaging probe 21 is irradiated to the surface of the irradiated object 30, the area of a light spot irradiated by the polarized light on the irradiated object 30 is similar to the area of the probe of the ultrasound transducer, the distance can ensure that the energy of the polarized light is in a preset value, the ultrasound transducer receives a photoacoustic signal generated by the polarized light acting on the irradiated object, and an image processing device (not shown) forms the photoacoustic signal into an image. Through this kind of mode, improve the control accuracy of the polarization state of light, promote the stability of the polarization state of light, and then improve the extraction ability of photoacoustic imaging to tissue specificity information.
Being different from the situation of prior art, the photoacoustic imaging apparatus of this embodiment adjusts the polarization adjusting assembly on the polarized photoacoustic imaging probe through using the polarized photoacoustic imaging probe of the above-mentioned embodiment, obtains the polarization state of the light that actually needs, improves the control accuracy of the polarization state of light, promotes the stability of the polarization state of light, and then improves the extraction ability of the photoacoustic imaging to the tissue specificity information.
The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings of the present application or are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.
Claims (11)
1. A polarized photoacoustic imaging probe, characterized in that the polarized photoacoustic imaging probe comprises:
the light source assembly comprises a light source and a lens assembly, wherein the lens assembly comprises a first plano-convex lens, a second plano-convex lens, a third plano-convex lens and a fourth plano-convex lens which are sequentially arranged from one side close to the light source; the convex surface of the first plano-convex lens faces to the side far away from the light source, the convex surface of the second plano-convex lens faces to the side far away from the light source, the convex surface of the third plano-convex lens faces to the side close to the light source, and the convex surface of the fourth plano-convex lens faces to the side close to the light source;
the polarizing device comprises a polarizing component and a polarization adjusting component, the polarizing component and the polarization adjusting component are arranged between the third plano-convex lens and the fourth plano-convex lens, the polarizing component is close to one side of the light source, the polarizing component is used for converting the light emitted by the light source component into polarized light, and the polarization adjusting component is configured to adjust the polarization state of the polarized light;
and the ultrasonic transducer is used for receiving the photoacoustic signal generated by the polarized light acting on the irradiated object.
2. Polarized photoacoustic imaging probe according to claim 1,
the polarization adjustment assembly includes:
adjusting the bracket;
the delay piece is arranged on the adjusting bracket;
wherein the adjusting bracket is configured to be movable under an external force to change the angle of the retarder so as to adjust the polarization state of the polarized light.
3. Polarized photoacoustic imaging probe according to claim 2,
the polarized photoacoustic imaging probe further comprises a first clamping assembly, wherein the first clamping assembly comprises a plurality of accommodating cavities for accommodating the light source assembly and the polarizing device.
4. Polarized photoacoustic imaging probe according to claim 3,
the first clamping assembly comprises a first clamping shell, a second clamping shell and a third clamping shell; the first clamping shell, the second clamping shell and the third clamping shell are connected in a matched mode to form a plurality of accommodating cavities.
5. Polarized photoacoustic imaging probe according to claim 4,
a first accommodating groove is formed in one side of the first end of the first clamping shell, and forms a first accommodating cavity with the second clamping shell for accommodating the light source;
a second accommodating groove is formed in one side of the second end of the first clamping shell, and a second accommodating cavity is formed by the second accommodating groove and the third clamping shell and is used for accommodating the lens assembly and the polarizing device;
the side wall of the second end of the first clamping shell is provided with a first extension part and a second extension part, and the first extension part and the second extension part are oppositely arranged to form an accommodating space for accommodating the ultrasonic transducer;
the first accommodating cavity is communicated with the second accommodating cavity, and a through hole is formed along the light path direction of the light source, so that light generated by the light source passes through the through hole.
6. Polarized photoacoustic imaging probe according to claim 5,
the second containing groove is provided with an opening, and the adjusting support is arranged corresponding to the opening, so that the scale part of the adjusting support is exposed through the opening.
7. Polarized photoacoustic imaging probe according to claim 5,
the polarized photoacoustic imaging probe further comprises a second clamping assembly, the second clamping assembly is arranged in the accommodating space, and the second clamping assembly comprises a third accommodating cavity for accommodating the ultrasonic transducer.
8. Polarized photoacoustic imaging probe according to claim 7,
the second clamping assembly comprises a fourth clamping shell and a fifth clamping shell, and the fourth clamping shell and the fifth clamping shell are connected in a matched mode to form the third accommodating cavity.
9. Polarized photoacoustic imaging probe according to claim 1,
the light path direction of the light source assembly and the detection direction of the ultrasonic transducer are intersected at a preset position, and a preset angle is formed between the light path direction and the detection direction; wherein the preset position is the placing position of the irradiated object.
10. Polarized photoacoustic imaging probe according to claim 9,
the length between the preset position and the ultrasonic transducer is 6-8 mm; or
The preset angle is 35-38 degrees.
11. A photoacoustic imaging apparatus, characterized in that the photoacoustic imaging apparatus comprises:
a photoacoustic imaging probe;
the image processing device is connected with the polarized photoacoustic imaging probe and used for controlling the work of the photoacoustic imaging probe, acquiring photoacoustic signals acquired by the photoacoustic imaging probe and forming an image based on the acquired photoacoustic signals;
wherein the photoacoustic imaging probe is according to any one of claims 1-10.
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