CN112045975A - Preparation process of mesh plug type patch - Google Patents

Preparation process of mesh plug type patch Download PDF

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Publication number
CN112045975A
CN112045975A CN202010874536.1A CN202010874536A CN112045975A CN 112045975 A CN112045975 A CN 112045975A CN 202010874536 A CN202010874536 A CN 202010874536A CN 112045975 A CN112045975 A CN 112045975A
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China
Prior art keywords
petal
mesh
shaping
plug type
circular arc
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CN202010874536.1A
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Chinese (zh)
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CN112045975B (en
Inventor
李恒平
郭勇
李绍霞
李彦霞
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Rizhao Tianyi Biomedical Technology Co ltd
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Rizhao Tianyi Biomedical Technology Co ltd
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C51/00—Shaping by thermoforming, i.e. shaping sheets or sheet like preforms after heating, e.g. shaping sheets in matched moulds or by deep-drawing; Apparatus therefor
    • B29C51/08—Deep drawing or matched-mould forming, i.e. using mechanical means only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C51/00—Shaping by thermoforming, i.e. shaping sheets or sheet like preforms after heating, e.g. shaping sheets in matched moulds or by deep-drawing; Apparatus therefor
    • B29C51/26—Component parts, details or accessories; Auxiliary operations
    • B29C51/30—Moulds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2240/001—Designing or manufacturing processes

Abstract

A preparation process of a mesh plug type patch belongs to the technical field of hernia repair patches, and particularly relates to a preparation process of a mesh plug type patch. The method is characterized by comprising the following steps: step 1, cutting petal-shaped polypropylene meshes: cutting the polypropylene mesh into petal-shaped polypropylene meshes; step 2, processing the hot-press forming device: the hot press molding device comprises a base, wherein a fixing hole is formed in the base; the fixing holes are arranged on the base in a longitudinal and transverse mode, and a shaping device is movably arranged on the fixing holes; the shaping device is sequentially inserted into the fixing holes and is matched with the petal-shaped polypropylene net sheets; step 3, heating and shaping: heating at 120-180 deg.C for 90-150 min, and shaping; step 4, cooling and mold taking: cooling to 20-35 deg.c and taking out; and 5, packaging a finished product for sterilization: sterilizing with ethylene oxide. The invention has the advantages of simple process, low labor intensity and low rejection rate.

Description

Preparation process of mesh plug type patch
Technical Field
The invention belongs to the technical field of hernia repair patches, and particularly relates to a preparation process of a mesh plug type patch.
Background
Hernias, i.e., a portion of a body tissue organ that has left the original site, pass through a body space, defect, or weakness and enter another site. At present, artificial materials are generally adopted for tension-free hernia repair, and the method can relieve postoperative pain and has the advantages of quick recovery, low recurrence rate and the like. At present, the mesh plug type hernia repair patch is generally formed by hot-pressing a polypropylene mesh through a copper die, and in the method, one set of copper die is needed for preparing one mesh plug type hernia repair patch, and hot-press forming is carried out by using a hot press, so that the process is complex, and the labor intensity is high. Meanwhile, the phenomena of eccentricity and pleating are easily generated, and the rejection rate is high.
Disclosure of Invention
The invention aims to provide a preparation process of a mesh plug type patch, so as to achieve the purposes of simple process, low labor intensity and low rejection rate.
The preparation process of the mesh plug type patch is characterized by comprising the following steps of:
step 1, cutting petal-shaped polypropylene meshes:
cutting the polypropylene mesh into petal-shaped polypropylene meshes by using a laser engraving machine;
step 2, processing the hot-press forming device:
the hot-press forming device comprises a base, wherein a fixing hole is formed in the base; the fixing holes are arranged on the base in a longitudinal and transverse mode, and a shaping device is movably arranged on the fixing holes; the shaping device is sequentially inserted into the fixing holes and is matched with the petal-shaped polypropylene net sheets;
step 3, heating and shaping:
placing the petal-shaped polypropylene mesh in a hot-press forming device, heating at 120-180 ℃ for 90-150 min, and shaping;
step 4, cooling and mold taking:
cooling the petal-shaped polypropylene mesh shaped in the step 3 to 30-35 ℃, and taking out;
and 5, packaging a finished product for sterilization:
and (4) packaging the petal-shaped polypropylene mesh in the step (4) to obtain a finished product of the mesh plug type patch, and sterilizing by adopting ethylene oxide.
Further, in the step 1, the cutting speed of the laser engraving machine is 5mm/s-20 mm/s.
Furthermore, the shaping device is of a centrosymmetric structure and comprises a petal shaping part, a folding part and a shaping fixing part, and the shaping fixing part is positioned at the central end of the shaping device; the petal design portion and the pleating portion are arranged adjacently, and the bottom of the petal design portion and the bottom of the pleating portion are fixedly connected with the design fixing portion.
Furthermore, the upper end of the petal shaping part is in a right circular arc shape, the upper end of the folding part is in a reverse circular arc shape, and the outer contour line of the petal shaping part is formed by sequentially connecting the right circular arc shape of the petal shaping part and the reverse circular arc line segment of the folding part end to end.
Further, the shaping fixing part comprises a central fixing end and a fixing connecting end, and the central fixing end is positioned at the central end of the shaping device; the fixed connecting end is encircled around the central fixed end and is formed by sequentially connecting multiple sections of positive arc and reverse arc line sections end to end, the radian of the positive arc is 20-40 degrees, and the radian of the reverse arc is 10-30 degrees.
Furthermore, the included angle alpha between the two side edges of the shaping device is 50-80 degrees.
Further, the arc of the right arc at the upper end of the petal shaping part is 20-40 degrees, and the arc of the reverse arc at the upper end of the pleating part is 10-30 degrees.
Further, the heating and shaping in the step 3 is to place the petal-shaped polypropylene mesh in a hot-press forming device, and heat the petal-shaped polypropylene mesh at the temperature of 150-160 ℃ for 120-140 min.
Furthermore, the concentration of the ethylene oxide is 700mg/L-900mg/L, the sterilization pressure is 0.06MPa-0.12MPa, the sterilization humidity is 60% -79%, the sterilization temperature is 56 ℃ -77 ℃, and the sterilization time is 12-15 h.
Further, the concentration of the ethylene oxide is 650-750 mg/L, the sterilization pressure is 0.08-0.10 MPa, the sterilization humidity is 66-76%, and the sterilization temperature is 61-67 ℃.
The innovation point and the beneficial effect of the preparation process of the mesh plug type patch provided by the invention are mainly embodied in the following aspects:
1. the invention provides a preparation process of a mesh plug type patch, wherein a hot press molding device is provided with a plurality of rows and a plurality of columns of fixing holes on a base transversely and longitudinally. The upper end of the fixing hole is movably provided with a pile of shaping devices, the shaping devices are sequentially inserted into the fixing hole, the petal-shaped polypropylene net sheets are placed on the shaping devices, one shaping device can be pressed on the petal-shaped polypropylene net sheets to be used as an upper die, the petal-shaped polypropylene net sheets can be placed in the shaping devices to be used as a lower die, and one upper die and one lower die are needed when one net plug type hernia repair sheet is prepared.
2. According to the preparation process of the mesh plug type patch, the shaping device is matched with the petal-shaped polypropylene mesh, when the petal-shaped polypropylene mesh deviates, one end of the petal-shaped polypropylene mesh protrudes out of the shaping device, and can be adjusted before hot-press forming, so that defective products or waste products are avoided after the petal-shaped polypropylene mesh is hot-press formed, and the defective product rate and the rejection rate are lower than one ten thousandth.
3. According to the preparation process of the mesh plug type patch, the included angle between two side edges of the shaping device, the regular arc radian of the upper end of the petal shaping part, the reverse arc radian of the upper end of the pleating part and the like are designed by combining with the physiological structure of a human body, so that the petal-shaped polypropylene mesh is convenient to carry out hot press molding, and meanwhile, the related technical requirements can be met, so that the mesh plug type patch has good supporting capacity and filling capacity, the edge friction of the mesh plug type hernia repair patch on human body tissues can be reduced to the greatest extent, and the pain of a surgical patient and the discomfort after surgery can be reduced.
4. According to the preparation process of the mesh plug type patch, after heating and shaping, cooling and mold taking are carried out, so that the petal-shaped polypropylene mesh can be prevented from deforming, and the defective rate and rejection rate are prevented from being influenced.
5. The preparation process of the mesh plug type patch provided by the invention packages the finished product, and adopts ethylene oxide for sterilization, so that the mesh plug type patch is sterile and meets the clinical use requirement.
6. The invention provides a preparation process of a mesh plug type patch, which has the following processing and preparation steps through sampling inspection:
Figure 926068DEST_PATH_IMAGE002
from the above table, the mesh plug type patch prepared by the preparation process of the mesh plug type patch provided by the invention can reach the related technical requirements.
Therefore, the invention has the positive effects of simple process, low labor intensity and low rejection rate.
Drawings
The accompanying drawings disclose, in part, specific embodiments of the present invention, wherein,
FIG. 1, a process flow diagram for steps 1-3 of the present invention;
FIG. 2 is a schematic structural diagram of the hot press molding apparatus of the present invention;
FIG. 3 is a schematic view of the structure of the setting device of the present invention;
fig. 4 is a top view of the structure of the setting device of the present invention.
Detailed Description
As shown in fig. 1, the preparation process of the mesh plug type patch provided by the invention comprises the following steps:
step 1, cutting petal-shaped polypropylene meshes: cutting the polypropylene mesh into petal-shaped polypropylene meshes 4 by using a laser engraving machine;
step 2, processing the hot press molding device 5: the hot-press forming device 5 comprises a base 2, and a plurality of fixing holes 3 are formed in the base 2; the fixing holes 3 are arranged on the base 2 in a plurality of rows and columns in a longitudinal and transverse mode, and the shaping device 1 is movably arranged on the fixing holes 3; a plurality of shaping devices 1 are sequentially inserted into the fixing holes 3, and the shaping devices 1 are matched with the petal-shaped polypropylene net sheets;
step 3, heating and shaping: placing the petal-shaped polypropylene net sheet 4 in a hot-press forming device 5, heating at 120-180 ℃ for 90-150 min, and shaping;
step 4, cooling and mold taking: cooling the petal-shaped polypropylene mesh 4 shaped in the step 3 to 30-35 ℃, and taking out;
and 5, packaging a finished product for sterilization: and (4) packaging the petal-shaped polypropylene mesh 4 obtained in the step (4) into a finished mesh plug type patch, and sterilizing by adopting ethylene oxide.
The invention is further illustrated by the following examples.
Example 1:
step 1, cutting petal-shaped polypropylene meshes: and cutting the polypropylene mesh by using a laser engraving machine, wherein the cutting speed of the laser engraving machine is 5-20 mm/s, and cutting the polypropylene mesh into the petal-shaped polypropylene mesh 4 with the D8cm specification.
Step 2, processing the hot press molding device 5: the hot-press forming device 5 comprises a base 2, and a plurality of fixing holes 3 are formed in the base 2; the fixing holes 3 are arranged on the base 2 in a plurality of rows and columns in a longitudinal and transverse mode, and the shaping device 1 is movably arranged on the fixing holes 3; a plurality of setting devices 1 are sequentially inserted into the fixing holes 3, and the setting devices 1 are matched with the petal-shaped polypropylene net sheets. And selecting the sizing device 1 corresponding to the specification of the petal-shaped polypropylene mesh, and selecting the sizing device 1 of D8cm if the petal-shaped polypropylene mesh is D8 cm.
Step 3, heating and shaping: place petal form polypropylene net piece 4 in hot briquetting device 5, place 1 st setting device 1 in the fixed orifices 3 of base 2, with 1 st petal form polypropylene net piece in 1 st setting device 1, place 2 nd setting device 1 on 1 st petal form polypropylene net piece. The center of the petal-shaped polypropylene net sheet is placed at the center of the shaping device 1, and the periphery of the petal-shaped polypropylene net sheet is placed at the periphery of the shaping device 1. When the petal-shaped polypropylene net sheet deviates, one end of the petal-shaped polypropylene net sheet is protruded outside the shaping device 1 and can be adjusted before hot press molding. Operate in proper order, place 2 nd petal form polypropylene net piece in 2 nd setting device 1, place 3 rd setting device 1 on the 2 nd petal form polypropylene net piece, petal form polypropylene net piece is not placed to setting device 1 at top. A pile of shaping devices 1 and petal-shaped polypropylene meshes are arranged in each fixing hole 3, the number of each pile of shaping devices 1 is N, and the number of the petal-shaped polypropylene meshes is N-1. If the number of the shaping apparatuses 1 per stack is 100, the number of the petaloid polypropylene net sheets is 99. And sequentially operating, and placing thousands of petal-shaped polypropylene net sheets in the fixing holes 3 of the base. Putting the base 2 together with the shaping device 1 and the petal-shaped polypropylene net sheet into an electric heating constant temperature blast drying oven, heating at 120-180 ℃ for 90-150 min, and shaping. 3000 plus 5000 petal-shaped polypropylene net pieces 4 can be placed in each electric heating constant temperature air blast drying box for hot press molding, the process is simple, and the labor intensity is low.
Step 4, cooling and mold taking: and (3) cooling the petal-shaped polypropylene mesh 4 shaped in the step (3) to 30-35 ℃, and taking out the petal-shaped polypropylene mesh to prevent the petal-shaped polypropylene mesh 4 from deforming and influencing the defective rate and rejection rate.
And 5, packaging a finished product for sterilization: and (3) packaging the petal-shaped polypropylene mesh 4 obtained in the step (4) into a finished product, namely a mesh plug type patch, and sterilizing by adopting ethylene oxide, wherein the concentration of the ethylene oxide is 700-900 mg/L, the sterilization pressure is 0.06-0.12 MPa, the sterilization humidity is 60-79%, the sterilization temperature is 56-77 ℃, and the sterilization time is 12-15 h.
Example 2:
step 1, cutting petal-shaped polypropylene meshes: and (3) cutting the polypropylene mesh by using a BCL0406N standard laser engraving machine, wherein the cutting speed of the laser engraving machine is 6-11 mm/s, and cutting the polypropylene mesh into a petal-shaped polypropylene mesh 4 with the D11cm specification.
Step 2, processing the hot press molding device 5: as shown in fig. 2, the hot press forming apparatus 5 includes a base 2, wherein 30 fixing holes 3 are transversely disposed on the base 2, 20 fixing holes 3 are longitudinally disposed, and 600 fixing holes are provided. 60 shaping devices 1 are movably arranged on each fixing hole 3, 3600 shaping devices 1 are sequentially inserted into the fixing holes 3, and the shaping devices 1 are matched with the petal-shaped polypropylene meshes. Selecting a sizing device 1 corresponding to the specification of the petal-shaped polypropylene mesh, and selecting the sizing device 1 of D11cm if the petal-shaped polypropylene mesh is D11 cm. The base 2 is in a square or rectangular parallelepiped shape. The shape of base 2 can with the layer frame tray looks adaptation of electric heat constant temperature forced air drying cabinet to can once place more petal form polypropylene net pieces and carry out thermoforming, reduction in production cost. The fixing hole 3 is matched with the shaping device 1, the middle lower part of the shaping device 1 is placed in the fixing hole 3, and the size of the fixing hole 3 is consistent with that of the middle lower part of the shaping device 1. The fixing hole 3 is any one of an inverted cone shape, a cylindrical shape, and a petal shape, and it is sufficient if the fixing device 1 can be fixed in the fixing hole 3 for hot press molding.
As shown in fig. 3, the shaping device 1 has a central symmetrical structure, and includes a petal shaping portion 11, a pleating portion 12, and a shaping fixing portion 13, and accordingly, the petal shaping portion 11, the pleating portion 12, and the shaping fixing portion 13 have a central symmetrical structure. The shaping fixing part 13 is located at the center end of the shaping device 1, and the petal shaping part 11 and the pleating part 12 are radially fixed around the shaping fixing part 13. Petal design portion 11 and the adjacent setting of pleating 12, 11 interval one of arbitrary two adjacent petal design portions 12 arrange, 11 interval one of arbitrary two adjacent petal design portions 11 arrange, the petal design portion 11 and the bottom of pleating 12 are fixed connection with design fixed part 13, and the upper end is the petal form. The petal shaping part 11, the pleating part 12 and the shaping fixing part 13 can enable the structure of the mesh plug type hernia repair patch formed by hot pressing to be a central symmetrical structure and a central axis symmetrical structure, so that the mesh plug type hernia repair patch is uniform in stress, has good supporting capacity and filling capacity, and can meet related technical requirements.
As shown in fig. 4, the upper end of the petal fixing part 11 is in a regular arc shape, and the arc shape faces the fixing part 13. The upper end of the pleat part 12 is reverse arc shape, the arc shape is back to the fixed part 13. The arc of the right circular arc at the upper end of the petal shaping part 11 is 20-40 degrees, and the arc of the reverse circular arc at the upper end of the pleating part 12 is 10-30 degrees. The outer contour line of the petal design part 11 is formed by sequentially connecting the head and the tail of a regular circular arc of the petal design part and a reverse circular arc-shaped line segment of the pleating part, the outer contour line of the mesh plug type hernia repair piece formed by hot pressing can be correspondingly formed by sequentially connecting the head and the tail of the regular circular arc and the reverse circular arc-shaped line segment, the mesh plug type hernia repair piece has good supporting capacity and filling capacity, the edge friction human tissue of the mesh plug type hernia repair piece can be reduced to the maximum extent, and the pain of a surgical patient and the discomfort after surgery are reduced.
As shown in fig. 4, the fixing and fixing portion 13 includes a central fixing end 131 and a fixing and connecting end 132, the central fixing end 131 is located at the central end of the fixing device 1, and the central fixing end 131 is matched with the center of the petaloid polypropylene mesh. The fixed connecting end 132 surrounds the center fixed end 131, and the fixed connecting end 132 is formed by sequentially connecting multiple sections of a positive circular arc and a reverse circular arc end to end, wherein the radian of the positive circular arc is 20-40 degrees, and the radian of the reverse circular arc is 10-30 degrees. The regular circular arc line segment of the fixed connecting end 132 corresponds to the regular circular arc line segment of the petal shaping portion, the reverse circular arc line segment of the fixed connecting end 132 corresponds to the reverse circular arc line segment of the folding portion, namely, both ends of the petal shaping portion 11 are regular circular arcs, and the regular circular arc radians are both 20-40 degrees. Both ends of the pleated part 12 are reverse circular arcs, and the radian of the reverse circular arcs are consistent and are both 10-30 degrees. Therefore, the design of human body physiological structure is combined, the petal-shaped polypropylene mesh is convenient to carry out hot press molding, and the supporting capacity and the filling capacity of the mesh plug type hernia repair patch which is formed by hot press molding can be improved.
As shown in fig. 4, the included angle α between the two side edges of the shaping device 1 is 50 ° to 80 °, and the shaping device 1 is integrally formed by stainless steel, so that the petal-shaped polypropylene mesh is conveniently subjected to hot press forming, and meanwhile, the requirements of related technologies can be met.
Step 3, heating and shaping: the petal-shaped polypropylene net sheets 4 are placed in a hot-press forming device 5, 60 shaping devices 1 are movably arranged on each fixed hole 3, 59 petal-shaped polypropylene net sheets 4 can be placed, 3540 petal-shaped polypropylene net sheets 4 are placed in 600 fixed holes, the base 2 together with the shaping devices 1 and the petal-shaped polypropylene net sheets are placed in an electric heating constant-temperature air blowing drying oven, and the base is heated at the temperature of 150-160 ℃ for 120-140 min for shaping.
Step 4, cooling and mold taking: and (4) cooling the petal-shaped polypropylene mesh 4 shaped in the step (3) to 32 ℃, and taking out.
And 5, packaging a finished product for sterilization: and (3) packaging the petal-shaped polypropylene mesh 4 obtained in the step (4) into a finished product, namely a mesh plug type patch, and sterilizing by adopting ethylene oxide, wherein the concentration of the ethylene oxide is 650-750 mg/L, the sterilization pressure is 0.08-0.10 MPa, the sterilization humidity is 66-76%, and the sterilization temperature is 61-67 ℃.
Example 3:
step 1, cutting petal-shaped polypropylene meshes: and cutting the polypropylene mesh by using a laser engraving machine, wherein the cutting speed of the laser engraving machine is 12-16 mm/s, and cutting the polypropylene mesh into a petal-shaped polypropylene mesh 4 with the D12cm specification.
Step 2, processing the hot press molding device 5: as shown in fig. 2, the hot press forming apparatus 5 includes a base 2, wherein 40 fixing holes 3 are transversely disposed on the base 2, and 20 fixing holes 3 are longitudinally disposed, for a total of 800 fixing holes. 51 shaping devices 1 are movably arranged on each fixing hole 3, the total 4100 shaping devices 1 are sequentially inserted into the fixing holes 3, and the shaping devices 1 are matched with the petal-shaped polypropylene meshes. Selecting a sizing device 1 corresponding to the specification of the petal-shaped polypropylene mesh, and selecting the sizing device 1 of D12cm if the petal-shaped polypropylene mesh is D12 cm.
The included angle alpha between the two side edges of the shaping device 1 is 56-76 degrees, the normal circular arc radian of the upper end of the petal shaping part 11 is 25-35 degrees, the reverse circular arc radian of the upper end of the pleating part 12 is 15-25 degrees, the normal circular arc radian of the fixed connecting end 132 is 25-35 degrees, and the reverse circular arc radian is 15-25 degrees, so that the petal-shaped polypropylene net piece is conveniently subjected to hot press molding by combining the design of human physiological structures, and meanwhile, the related technical requirements can be met.
Step 3, heating and shaping: the petal-shaped polypropylene net sheets 4 are placed in a hot-press forming device 5, 51 shaping devices 1 are movably arranged on each fixed hole 3, 50 petal-shaped polypropylene net sheets 4 can be placed, 4000 petal-shaped polypropylene net sheets 4 are placed in 800 fixed holes, the base 2 together with the shaping devices 1 and the petal-shaped polypropylene net sheets are placed in an electric heating constant-temperature air blowing drying box, and the base is heated at 156-158 ℃ for 125-130 min and shaped.
Step 4, cooling and mold taking: and (4) cooling the petal-shaped polypropylene mesh 4 shaped in the step (3) to 33 ℃, and taking out.
And 5, packaging a finished product for sterilization: and (3) packaging the petal-shaped polypropylene mesh 4 obtained in the step (4) into a finished product, namely a mesh plug type patch, and sterilizing by adopting ethylene oxide, wherein the concentration of the ethylene oxide is 670-700 mg/L, the sterilization pressure is 0.09MPa, the sterilization humidity is 65-75%, and the sterilization temperature is 60-62 ℃.
Example 4:
step 1, cutting petal-shaped polypropylene meshes: and (3) cutting the polypropylene mesh by using a laser engraving machine, wherein the cutting speed of the laser engraving machine is 17-19 mm/s, and cutting the polypropylene mesh into petal-shaped polypropylene meshes 4 with the specification of D12.5 cm.
Step 2, processing the hot press molding device 5: as shown in fig. 2, the hot press forming apparatus 5 includes a base 2, 50 fixing holes 3 are transversely disposed on the base 2, 20 fixing holes 3 are longitudinally disposed, and 1000 fixing holes are provided. 46 shaping devices 1 are movably arranged on each fixed hole 3, the 4600 shaping devices 1 are sequentially inserted into the fixed holes 3, and the shaping devices 1 are matched with the petal-shaped polypropylene meshes. And selecting a shaping device 1 corresponding to the specification of the petal-shaped polypropylene mesh, and if the petal-shaped polypropylene mesh is D12.5cm, selecting the shaping device 1 with D12.5cm.
The included angle alpha between the two side edges of the shaping device 1 is 60-65 degrees, the normal circular arc radian of the upper end of the petal shaping part 11 is 28-30 degrees, the reverse circular arc radian of the upper end of the folding part 12 is 16-18 degrees, the normal circular arc radian of the fixed connecting end 132 is 28-30 degrees, and the reverse circular arc radian is 16-18 degrees, and the design of human body physiological structure is combined, so that the petal-shaped polypropylene mesh can be conveniently subjected to hot press molding, and meanwhile, the related technical requirements can be met.
Step 3, heating and shaping: placing petal form polypropylene net piece 4 in hot briquetting device 5, 46 setting devices 1 are movably arranged on every fixed orifices 3, 45 petal form polypropylene net pieces 4 can be placed, 4500 petal form polypropylene net pieces 4 are placed in 1000 fixed orifices, base 2 together with setting devices 1 and petal form polypropylene net pieces are placed in an electric heating constant temperature blast air drying oven, heating is carried out at 155 ℃ for 135min, and setting is carried out.
Step 4, cooling and mold taking: and (4) cooling the petal-shaped polypropylene mesh 4 shaped in the step (3) to 34 ℃, and taking out.
And 5, packaging a finished product for sterilization: and (4) packaging the petal-shaped polypropylene mesh 4 obtained in the step (4) into a finished product, namely a mesh plug type patch, and sterilizing by adopting ethylene oxide, wherein the concentration of the ethylene oxide is 720mg/L, the sterilization pressure is 0.11MPa, the sterilization humidity is 70%, and the sterilization temperature is 65 ℃.

Claims (10)

1. A preparation process of a mesh plug type patch is characterized by comprising the following steps:
step 1, cutting petal-shaped polypropylene meshes:
cutting the polypropylene mesh into petal-shaped polypropylene meshes (4) by using a laser engraving machine;
step 2, processing the hot-press forming device (5):
the hot-press forming device (5) comprises a base (2), and a fixing hole (3) is formed in the base (2); the fixing holes (3) are arranged on the base (2) in a longitudinal and transverse mode, and the fixing holes (3) are movably provided with the shaping device (1); the shaping device (1) is sequentially inserted into the fixing hole (3), and the shaping device (1) is matched with the petal-shaped polypropylene net piece (4);
step 3, heating and shaping:
placing the petal-shaped polypropylene mesh (4) in a hot-press molding device (5), heating at 120-180 ℃ for 90-150 min, and shaping;
step 4, cooling and mold taking:
cooling the petal-shaped polypropylene mesh (4) shaped in the step (3) to 30-35 ℃, and taking out;
and 5, packaging a finished product for sterilization:
and (4) packaging the petal-shaped polypropylene mesh (4) obtained in the step (4) into a finished product of a mesh plug type patch, and sterilizing by adopting ethylene oxide.
2. The process for preparing mesh plug type patch according to claim 1, wherein in the step 1, the cutting speed of the laser engraving machine is 5mm/s-20 mm/s.
3. The mesh plug type patch preparation process according to claim 1, wherein the shaping device (1) is a central symmetrical structure and comprises a petal shaping part (11), a pleating part (12) and a shaping fixing part (13), and the shaping fixing part (13) is positioned at the central end of the shaping device (1); the petal design part (11) and the pleating part (12) are arranged adjacently, and the bottoms of the petal design part (11) and the pleating part (12) are fixedly connected with the design fixing part (13).
4. The preparation process of the mesh plug type patch according to claim 3, wherein the upper end of the petal design part (11) is in a shape of a right circular arc, the upper end of the pleated part (12) is in a shape of a reverse circular arc, and the outer contour line of the petal design part (11) is formed by sequentially connecting the right circular arc of the petal design part and the reverse circular arc line segment of the pleated part end to end.
5. Process for the preparation of a mesh patch according to claim 3 or 4, wherein the shaped fixing portion (13) comprises a central fixing end (131) and a fixing connection end (132), the central fixing end (131) being located at the central end of the shaping device (1); the fixed connecting end (132) surrounds the periphery of the central fixed end (131), the fixed connecting end (132) is formed by sequentially connecting multiple sections of a right circular arc and a reverse circular arc end to end, the radian of the right circular arc is 20-40 degrees, and the radian of the reverse circular arc is 10-30 degrees.
6. Process for the preparation of a mesh patch according to claim 3 or 4, characterized in that the angle α between the two sides of the sizing device (1) is between 50 ° and 80 °.
7. The preparation process of the mesh plug type patch according to claim 4, wherein the arc of the right circular arc at the upper end of the petal shaping part (11) is 20-40 degrees, and the arc of the reverse circular arc at the upper end of the pleating part (12) is 10-30 degrees.
8. The preparation process of the mesh plug type patch according to claim 1, wherein the heating and shaping in the step 3 is to place the petal-shaped polypropylene mesh (4) in a hot-press forming device (5) and heat the petal-shaped polypropylene mesh at 150-160 ℃ for 120-140 min.
9. The process for preparing a mesh-plug type patch according to claim 1, wherein the concentration of the ethylene oxide is 700mg/L to 900mg/L, the sterilization pressure is 0.06MPa to 0.12MPa, the sterilization humidity is 60 percent to 79 percent, the sterilization temperature is 56 ℃ to 77 ℃, and the sterilization time is 12 to 15 hours.
10. The process for preparing a mesh-plug type patch according to claim 8, wherein the concentration of ethylene oxide is 650mg/L to 750mg/L, the sterilization pressure is 0.08MPa to 0.10MPa, the sterilization humidity is 66% to 76%, and the sterilization temperature is 61 ℃ to 67 ℃.
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WO2012034126A1 (en) * 2010-09-10 2012-03-15 The Regents Of The University Of Colorado, A Body Corporate Medical fabric with integrated shape memory polymer
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