CN102824655A - Biological artificial bone and preparation method thereof - Google Patents
Biological artificial bone and preparation method thereof Download PDFInfo
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- CN102824655A CN102824655A CN2012103046277A CN201210304627A CN102824655A CN 102824655 A CN102824655 A CN 102824655A CN 2012103046277 A CN2012103046277 A CN 2012103046277A CN 201210304627 A CN201210304627 A CN 201210304627A CN 102824655 A CN102824655 A CN 102824655A
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Abstract
The invention discloses a biological artificial bone and a preparation method thereof. The biological artificial bone is prepared from hydroxyapatite (1) and calcium phosphate (2), and the preparation method comprises synthesizing (2), water washing (4), draining (5), drying (6), crushing (7), sieving (8), ball milling (9), calcining with middle temperature (10), moulding (11), drying (12), sintering (13), cooling (14), water boiling (15), drying (16), packaging for the first time (17), disinfecting for the first time (18), packaging for the second time (19), disinfecting for the second time (20) and externally packaging (21). The prepared bio-orthopedic repair materials have good biocompatibility, bone conductivity and machinery bearing capability, is easy to attach for osteoblast and can control degradation speed. The preparation method and technology thereof are all completed in an aseptic producing room, safe and aseptic, and thus can reduce generation of postoperative infection and other complications of patients.
Description
Technical field:
The present invention relates to a kind of bio-artificial bone and preparation method thereof.
Background technology:
Bone defective, the bone that is caused by osteopathia, bone tumor, bone wound is damaged, bone is empty is one of common osteopathia, and the repairing of above-mentioned defective, treatment are to adopt methods such as metal material connection, homogeneous allogenic bone transplantation, autologous bone transplanting traditionally; Though these methods can be treated a part of osteopathia patient, have bigger limitation and shortcoming, for example adopt metal material to connect treatment, biocompatibility is relatively poor, and repellency is strong, and the patient also must implement second operation and take out; The main difficult point of homogeneous allogenic bone transplantation is the rejection problem, and behind the bone grafting, infection, bone does not connect, tumor recurrence, the complication such as (immunity) that spreads disease happen occasionally simultaneously, and the bone source is also very limited; Autologous bone transplanting causes on the one hand and supplies bone district doctor's originality to destroy, and the patient receives repeatedly painful, and the bone amount is extremely limited, is restricted clinically.
Summary of the invention:
The purpose of this invention is to provide a kind of bio-artificial bone and preparation method thereof;
The present invention adopts following technical scheme to realize its goal of the invention; A kind of bio-artificial bone and preparation method thereof; It is processed by hydroxyapatite 1 and calcium phosphate 2, and adopt synthetic 3, washing 4, drain 5, oven dry 6, broken 7, sieve 8, ball milling 9, middle temperature calcining 10, molding 11, oven dry 12, sintering 13, cooling 14, decocting in water 15, oven dry 16, pack 17 for the first time, sterilize 18 for the first time, pack 19 for the second time, sterilize 20 for the second time, outer package 21 completion its preparation methods;
Synthetic 3: with hydroxyapatite 1 and calcium phosphate 2 synthetic composite materials;
Washing 4: wash the impurity in the composite that removes hydroxyapatite 1 and calcium phosphate 2;
Drain 5: the composite after the roguing is drained with special-purpose gauze;
Oven dry 6: the composite after will draining is put into drying baker and is baked into colloidal;
Broken 7: the blocky composite of glue is broken with pulverizer;
Sieve 8: the material after the fragmentation is sieved with special screen cloth;
Ball milling 9: use powder after the roller ball grinding machine will sieve to be finish-ground to granular size and be 180-200 purpose powder;
Middle temperature calcining 10: the material after will finish grinding is put into warm calcining furnace calcining, with the intermolecular structural capacity of reinforcing material;
Molding 11: powder is inserted bubbles model, make embryo's molding;
Oven dry 12: the embryo of molding inserted in the dehydrator dry;
Sintering 13: the embryo after will drying inserts in the high temperature furnace, intensification be 1200 the degree high temperature furnace in calcine, make material molecule reach consistent with the skeleton molecular structure;
Cooling 14: the material after the high-temperature calcination is inserted the sterilizing room natural cooling;
Decocting in water 15: the cooling back was removed impurities of materials in 40-50 minute with the distilled water distillation;
Oven dry 16: the material after will distilling is inserted in the oven and is dried;
Ground floor packing 17: material is carried out ground floor with special-purpose special small package bag pack;
For the first time sterilize 18: packaged material is inserted in the sterilization cabinet that temperature is the 121-125 degree carried out sterilizing the first time 50 minutes;
Overpack 19: the small package bag material after will sterilizing carries out packing the second time with special-purpose special big packaging bag;
For the second time sterilize 20: packaged material is inserted in the sterilization cabinet that temperature is the 121-125 degree carried out sterilizing the second time 50 minutes;
Outer package 21: the special-purpose damp-prrof packing bag with this product is packed.
All processes of the present invention are all accomplished in the sterile production chamber.
Owing to adopted above technical scheme; The present invention has realized its goal of the invention preferably; The bio-artificial bone is the biological orthopaedics repair materials by the synthetic processing of hydroxyapatite-calcium phosphate (HATCP), and it has excellent biological compatibility, bone conductibility, mechanical bearing capacity, osteoblast is easy to attach and advantage such as controlled degradation speed; Its preparation method and technology all accomplishes in the sterile production chamber, and safety asepsis has reduced the generation of complication such as the patient infects after surgery.
Description of drawings:
Accompanying drawing 1 is a process chart of the present invention.
The practical implementation method:
Below in conjunction with embodiment summary of the invention is further specified:
Embodiment 1:
Can know by summary of the invention; A kind of bio-artificial bone and preparation method thereof; It is processed by hydroxyapatite 1 and calcium phosphate 2, and adopt synthetic 3, washing 4, drain 5, oven dry 6, broken 7, sieve 8, ball milling 9, middle temperature calcining 10, molding 11, oven dry 12, sintering 13, cooling 14, decocting in water 15, oven dry 16, ground floor packing 17, sterilize 18 for the first time, overpack 19, sterilize 20 for the second time, outer package 21 completion its preparation methods.
Hydroxyapatite 1 of the present invention is meant: the oxyhydroxide of calcium phosphate; Hydroxyapatite has good biocompatibility, is a kind of inducible factor of skeleton, good biocompatibility, and affinity is high.
Calcium phosphate 2 of the present invention is meant: claim tricalcium phosphate again; Tricalcium phosphate has excellent biological compatibility, biological activity and biological degradability; Be ideal human body hard tissue reparation and substitution material, medically normally used is a kind of specific form-bata-tricalcium phosphate of tricalcium phosphate, and bata-tricalcium phosphate mainly is made up of calcium, phosphorus; Its composition is similar with the inorganic constituents of human body bone matrix, is combined with skeleton; Human body cell can normal growth, differentiation and breeding on the bata-tricalcium phosphate material.Prove through lot of experiments: bata-tricalcium phosphate has no adverse reaction to the bone marrow hematogenesis function, no rejection, and no acute toxic reaction, carcinogenesis does not have irritated phenomenon; Therefore bata-tricalcium phosphate can be widely used in joint and spinal fusion, extremity wound, the surgery of oral and maxillofacial surgery, cardiovascular surgery, and the aspects such as cavity of filling up periodontal.
Of the present invention synthetic 3 are meant: a technological process specifically is meant hydroxyapatite 1 and calcium phosphate 2 synthetic composite materials.
Washing 4 of the present invention is meant: a technological process specifically is meant the impurity of washing in the composite that removes hydroxyapatite 1 and calcium phosphate 2.
Of the present inventionly drain 5 and be meant: a technological process specifically is meant the composite after the roguing is drained with special-purpose gauze.
Oven dry 6 of the present invention is meant: a technological process is meant that specifically the composite after draining is put into drying baker is baked into the blob of viscose shape.
Pulverizing 7 of the present invention is meant: a technological process specifically is meant with disintegrating machine the blocky composite of glue is pulverized.
Of the present invention sieving 8 is meant: a technological process specifically is meant the material after the fragmentation is sieved with special screen cloth.
Ball milling 9 of the present invention is meant: a technological process is meant that specifically the material that will use after the roller ball grinding machine will sieve is finish-ground to granular size and is 180-200 purpose powder.
Temperature calcining 10 is meant in of the present invention: a technological process is meant that specifically the material behind the correct grinding is put into warm calcining furnace to be calcined, with the intermolecular structural capacity of reinforcing material.
Molding 11 of the present invention is meant: a technological process, and specifically be meant powder is inserted bubbles model, make embryo's molding.
Oven dry 12 of the present invention is meant: a technological process is meant specifically that embryo with molding inserts in the dehydrator to dry.
Sintering 13 of the present invention is meant: a technological process, specifically be meant with the oven dry after the embryo insert in the high temperature furnace, intensification be 1200 the degree high temperature furnace in calcine, make material molecule reach consistent with the skeleton molecular structure.
Cooling 14 of the present invention is meant: a technological process specifically is meant the material after the high-temperature calcination is inserted the sterilizing room natural cooling.
Decocting in water 15 of the present invention is meant: a technological process, and specifically be meant cooled material is inserted in the distilled water, removed impurities of materials in 40-50 minute with the distilled water distillation.
Oven dry 16 of the present invention is meant: a technological process specifically is meant the material after the distillation is inserted in the oven and dried.
Ground floor packing 17 of the present invention is meant: a technological process is meant that specifically material is carried out ground floor with special-purpose special small package bag to be packed.
Sterilize the first time of the present invention and 18 be meant: a technological process specifically is meant packaged material inserted in the vacuum sterilizer that temperature is the 121-125 degree and carried out sterilizing the first time 50 minutes.
Overpack 19 of the present invention is meant: a technological process specifically is meant the small package bag material after the sterilization is carried out packing the second time with special-purpose special big packaging bag.
Sterilize the second time of the present invention and 20 be meant: a technological process specifically is meant packaged material inserted in the vacuum sterilizer that temperature is the 121-125 degree and carried out sterilizing the second time 50 minutes.
Outer package 21 of the present invention is meant: a technological process specifically is meant with the special-purpose damp-prrof packing bag of this product and packs.
All processes of the present invention are all accomplished in the sterile production chamber.
| Reference numerals | The labelling title | Reference numerals | The labelling title |
| 1 | Hydroxyapatite 1 | 12 | Oven dry 12 |
| 2 | Calcium phosphate 2 | 13 | Sintering 13 |
| 3 | Synthetic 3 | 14 | Cooling 14 |
| 4 | Washing 4 | 15 | Decocting in water 15 |
| 5 | Drain 5 | 16 | Oven dry 16 |
| 6 | Oven dry 6 | 17 | Ground floor packing 17 |
| 7 | Broken 7 | 18 | For the first time sterilize 18 |
| 8 | Sieve 8 | 19 | Overpack 19 |
| 9 | Ball milling 9 | 20 | For the second time sterilize 20 |
| 10 | Middle temperature calcining 10 | 21 | Outer package 21 |
| 11 | Molding 11 | ? | ? |
Claims (1)
1. bio-artificial bone and preparation method thereof, it is processed by hydroxyapatite (1) and calcium phosphate (2); It is characterized in that adopting synthetic (3), washing (4), drain (5), oven dry (6), broken (7), sieve (8), ball milling (9), the calcining of middle temperature (10), molding (11), oven dry (12), sintering (13), cooling (14), decocting in water (15), oven dry (16), packing (17), sterilization (18) for the first time, packing (19), sterilization (20) for the second time, outer package (21) completion its preparation method for the second time for the first time;
Synthetic (3): with hydroxyapatite 1 and calcium phosphate 2 synthetic composite materials;
Washing (4): wash the impurity in the composite that removes hydroxyapatite 1 and calcium phosphate 2;
Drain (5): the composite after the roguing is drained with special-purpose gauze;
Oven dry (6): the composite after will draining is put into drying baker and is baked into colloidal;
Broken (7): the blocky composite of glue is broken with pulverizer;
Sieve (8): the material after the fragmentation is sieved with special screen cloth;
Ball milling (9): use powder after the roller ball grinding machine will sieve to be finish-ground to granular size and be 180-200 purpose powder;
Middle temperature calcining (10): the material after will finish grinding is put into warm calcining furnace calcining, with the intermolecular structural capacity of reinforcing material;
Molding (11): powder is inserted bubbles model, make embryo's molding;
Oven dry (12): the embryo of molding inserted in the dehydrator dry;
Sintering (13): the embryo after will drying inserts in the high temperature furnace, intensification be 1200 the degree high temperature furnace in calcine, make material molecule reach consistent with the skeleton molecular structure;
Cooling (14): the material after the high-temperature calcination is inserted the sterilizing room natural cooling;
Decocting in water (15): the cooling back was removed impurities of materials in 40-50 minute with the distilled water distillation;
Oven dry (16): the material after will distilling is inserted in the oven and is dried;
Ground floor packing (17): material is carried out ground floor with special-purpose special small package bag pack;
Sterilize (18) for the first time: packaged material is inserted in the sterilization cabinet that temperature is the 121-125 degree carried out sterilizing the first time 50 minutes;
Overpack (19): the small package bag material after will sterilizing carries out packing the second time with special-purpose special big packaging bag;
Sterilize (20) for the second time: packaged material is inserted in the sterilization cabinet that temperature is the 121-125 degree carried out sterilizing the second time 50 minutes;
Outer package (21): the special-purpose damp-prrof packing bag with this product is packed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103046277A CN102824655A (en) | 2012-08-24 | 2012-08-24 | Biological artificial bone and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012103046277A CN102824655A (en) | 2012-08-24 | 2012-08-24 | Biological artificial bone and preparation method thereof |
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| Publication Number | Publication Date |
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| CN102824655A true CN102824655A (en) | 2012-12-19 |
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| CN2012103046277A Pending CN102824655A (en) | 2012-08-24 | 2012-08-24 | Biological artificial bone and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103183507A (en) * | 2013-03-19 | 2013-07-03 | 徐州工业职业技术学院 | Preparation method of biphase calcium phosphate ceramic containing beta-calcium pyrophosphate |
| CN103977454A (en) * | 2014-05-28 | 2014-08-13 | 华东理工大学 | Magnesium phosphate/wheat protein composite material, as well as preparation method and application thereof |
| JP2020050581A (en) * | 2018-09-25 | 2020-04-02 | Ｄｏｗａエコシステム株式会社 | Hydroxyapatite and manufacturing method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101456751A (en) * | 2009-01-09 | 2009-06-17 | 北京理工大学 | Technique for preparing calcium orthophosphate base bioceramic by doping zinc oxide crystal whisker |
-
2012
- 2012-08-24 CN CN2012103046277A patent/CN102824655A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101456751A (en) * | 2009-01-09 | 2009-06-17 | 北京理工大学 | Technique for preparing calcium orthophosphate base bioceramic by doping zinc oxide crystal whisker |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103183507A (en) * | 2013-03-19 | 2013-07-03 | 徐州工业职业技术学院 | Preparation method of biphase calcium phosphate ceramic containing beta-calcium pyrophosphate |
| CN103977454A (en) * | 2014-05-28 | 2014-08-13 | 华东理工大学 | Magnesium phosphate/wheat protein composite material, as well as preparation method and application thereof |
| JP2020050581A (en) * | 2018-09-25 | 2020-04-02 | Ｄｏｗａエコシステム株式会社 | Hydroxyapatite and manufacturing method thereof |
| JP7373330B2 (en) | 2018-09-25 | 2023-11-02 | Ｄｏｗａエコシステム株式会社 | Method for manufacturing hydroxyapatite |
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Application publication date: 20121219 |