CN112044386B

CN112044386B - Heparin sodium production facility based on secondary enzymolysis method

Info

Publication number: CN112044386B
Application number: CN202010955560.8A
Authority: CN
Inventors: 张琴琴
Original assignee: Pujiang Kairui Biotechnology Co ltd
Current assignee: Pujiang Kairui Biotechnology Co ltd
Priority date: 2020-09-11
Filing date: 2020-09-11
Publication date: 2022-01-25
Anticipated expiration: 2040-09-11
Also published as: CN112044386A

Abstract

The invention discloses heparin sodium production equipment based on a secondary enzymolysis method, which comprises a cylinder, support legs, a stirring device, a cover plate, a first rotating part and a detection structure, wherein the cylinder is provided with a support leg; the stirring device comprises a stirring cavity arranged in the barrel, a first cavity arranged on the inner wall of the barrel, a heating pipe arranged in the first cavity, a motor arranged on the cover plate, a telescopic stirring structure arranged below the cover plate, a first auxiliary structure arranged on the side wall of the stirring cavity and a discharging structure arranged at the bottom of the stirring cavity; according to the invention, through the arrangement of the telescopic stirring structure, the stirring shaft can be contracted after stirring is finished, and the stirring shaft is opened in a turnover cover mode, so that the design height of the tank body is higher, the floor area is reduced, the accommodating volume of equipment is increased, and the interior is more convenient to clean; meanwhile, the heating efficiency is effectively guaranteed in a side wall heating mode, the internal temperature balance is guaranteed, and meanwhile the preparation efficiency is improved.

Description

Heparin sodium production facility based on secondary enzymolysis method

Technical Field

The invention belongs to the technical field of biotechnology, and particularly relates to heparin sodium production equipment based on a secondary enzymolysis method.

Background

In the process of preparing heparin sodium, the prepared porcine intestinal mucosa raw material is added into a sodium chloride aqueous solution with the salinity of 4.0-4.5 ℃, the mixture is uniformly mixed to obtain a mixed solution, a pH regulator is added to adjust the pH value of the mixed solution, the mixed solution is heated to 33 +/-2 ℃, alkaline protease is added, the temperature is continuously raised to 38 +/-2 ℃, and then the enzymolysis is kept for 1-1.5 hours at constant temperature, so that the first enzymolysis is completed.

And after the first enzymolysis is finished, adding a pH regulator to regulate the pH value of the mixed solution, regulating the salinity of the mixed solution to 3.0-3.5 ℃, continuously heating to 55 +/-1 ℃, and keeping enzymolysis for 2.5-3 hours at constant temperature to finish the second enzymolysis.

Needs to carry out heat preservation stirring to a certain extent in the enzymolysis process, so stirring equipment needs to be used, and needs to be cleaned after preparation, thereby avoiding breeding of internal bacteria, the equipment on the conventional market is characterized in that in the process of taking out the stirring shaft in the cleaning process, because the length of the stirring shaft is longer, the whole stirring shaft needs to be taken out from the barrel body in a mode of lifting the stirring shaft vertically upwards, the height of the equipment cannot be over-high due to the mode, otherwise, the stirring shaft can be taken out in a mode of manually climbing a ladder and the like, on one hand, the cleaning is inconvenient, on the other hand, certain danger exists for workers, the stirring equipment on the market also has a stirring shaft in a flip-cover mode, but the flip-cover mode needs the size of an opening to be matched with the length of the stirring shaft, so the stirring device on the market is generally higher in height and larger in short floor area, but the capacity is smaller, because the preparation time is longer, the yield is low, meanwhile, the heating mode in the stirring process usually adopts a water bath heating method, but the heating pipes are all arranged at the bottom, and the heating process is from bottom to top, so that the temperature difference between the top and the bottom is larger, and the subsequent temperature is easy to cause uneven.

Disclosure of Invention

In order to overcome the defects of the prior art, the invention provides heparin sodium production equipment based on a secondary enzymolysis method, which has the advantages of small occupied area and high preparation efficiency.

In order to achieve the purpose, the invention adopts the following technical scheme: a heparin sodium production device based on a secondary enzymolysis method comprises a cylinder body, support legs arranged at the bottom of the cylinder body, a stirring device arranged in the cylinder body, a cover plate arranged above the cylinder body, a first rotating part used for connecting the cylinder body and the cover plate, and a detection structure arranged on one side of the cylinder body; the stirring device comprises a stirring cavity arranged in the barrel, a first cavity arranged on the inner wall of the barrel, a heating pipe arranged in the first cavity, a motor arranged on the cover plate, a telescopic stirring structure arranged below the cover plate, a first auxiliary structure arranged on the side wall of the stirring cavity and a discharging structure arranged at the bottom of the stirring cavity; through the arrangement of the telescopic stirring structure, the stirring shaft can be contracted after stirring is finished, so that the stirring shaft is shortened, and then the stirring shaft is opened in a flip-open manner, which effectively facilitates the moving-out of the stirring shaft, and the flip-open manner is more convenient and labor-saving compared with an upward lifting manner, and is not easy to damage, the thickness of the cylinder body can be set into a relatively fine cylinder body in the design process of the cylinder body, so that the floor area is saved, on the other hand, the telescopic stirring shaft can adapt to a longer manner, so that the design height of the cylinder body is higher, so that the accommodating volume of the equipment is effectively increased, because the preparation manner is longer, more preparation amount can effectively improve the preparation product, so that the working efficiency of the equipment is effectively improved, and meanwhile, the flip-open manner enables the stirring shaft to be more conveniently taken out when the cleaning is needed, the ascending is not needed in the taking-out process, and the safety of personnel is ensured, meanwhile, the overall gravity center height of the stirring shaft is effectively improved in a retraction mode, so that the gravity center is closer to the first rotating piece, the difficulty of turning the cover is effectively reduced, the operation is convenient, the internal cleaning is more convenient, the accumulation of bacteria is avoided, and the pollution of the extract is effectively avoided; mode through the lateral wall intensification, mode of intensification in the side direction outside, compare the mode heating in the bottom heating, the mode heating range that heats with the multiaspect is bigger, the diffusion form is rapider, and because the tube-shape is centripetal structure, the direction of heat transfer is the position towards the staving centre of a circle, it is quicker to transfer heat, concentrated form makes the center be heated more rapidly, simultaneously to narrow and high barrel heating effect more obvious in this scheme, the heat preservation effect is more superior, heating efficiency has effectively been guaranteed, inside temperature balance has been guaranteed, the efficiency of preparation has been improved simultaneously.

The telescopic stirring structure comprises a first stirring shaft arranged below the cover plate, a fixed groove used for fixing the first stirring shaft on the cover plate, a second stirring shaft capable of moving back and forth in the first stirring shaft, a first guide groove arranged on the first stirring shaft, a first opening arranged on the second stirring shaft, a third stirring shaft capable of moving back and forth in the second stirring shaft, a second guide groove arranged on the inner wall of the second stirring shaft, a second opening arranged on the third stirring shaft, a threaded rod arranged on the motor, a first sleeve sleeved on the threaded rod, a second sleeve with one end fixedly connected to the bottom of the third stirring shaft, stirring blade structures arranged on the second stirring shaft and the third stirring shaft, and a rotation stopping structure arranged on the cover plate; threads are arranged on the inner side and the outer side of the first sleeve; the inner wall of the second sleeve is provided with threads; the second sleeve is sleeved on the first sleeve; taking the stirring shaft in a contracted state as an example, when the stirring shaft needs to work, the rotation of the motor drives the threaded rod to rotate, at the moment, the first stirring shaft and the second stirring shaft are matched with the first opening through the first guide groove, the second stirring shaft is limited by the first guide groove on the first stirring shaft and is in a static state relative to the first stirring shaft and only can move up and down, the second stirring shaft and the third stirring shaft are matched with each other through the second guide groove and the second opening, so the second sleeve is in a static state relative to the third stirring shaft, when the threaded rod rotates, the first sleeve is driven to rotate, the rotation of the first sleeve drives the first sleeve to rotate, the second sleeve is driven to move downwards through the matching between the second sleeve and the threads of the first sleeve, or the first sleeve is driven to move downwards through the matching between the threads, both orders are all can, all extend to the limit when first sleeve pipe and second sleeve pipe, the rotation of threaded rod this moment will drive whole puddler and rotate, thereby stir inside, otherwise, the reversal of motor will drive the (mixing) shaft and accomodate, the main structure as the extension pipe of first sleeve pipe exists, the setting of this structure will be guaranteed that longer (mixing) shaft can obtain accomodating of great degree, the length of (mixing) shaft under the state of accomodating has effectively been shortened, the holding volume is less, promote holistic focus effectively, thereby the operation smoothness of flip form has been guaranteed, touch between the apparatus has effectively been avoided simultaneously, thereby the life of apparatus has been guaranteed, the maintenance cost is reduced.

The stirring blade structure comprises a first chute arranged on the second stirring shaft and the third stirring shaft, a plurality of first sliding blocks arranged in the first chute, a groove arranged on the first sliding block, a waterproof film connected with two adjacent first sliding blocks, a folding sheet arranged in the groove, water-isolating sheets arranged on two sides of the folding sheet, a first elastic piece arranged on the folding sheet, a blocking sheet sleeved on the second stirring shaft and the third stirring shaft, a connecting rod penetrating through the first sliding block, a stirring blade fixedly connected with one end of the connecting rod, a first through groove arranged on the stirring blade, a plurality of guide plates arranged in the first through groove, and an adjusting structure arranged on the first sliding block; the guide plate forms a certain angle with the vertical direction; the guide plates arranged on two adjacent stirring blades are opposite in inclination direction; when the stirring shafts are accommodated, taking the second stirring shaft and the third stirring shaft as an example, when the third stirring shaft moves upwards relative to the second stirring shaft, the second stirring rod pushes the plugging piece to move downwards, the plugging piece is propped against the upper part of the uppermost first sliding block, so that a sealing effect is achieved, so that liquid is prevented from entering the plugging piece, thereby ensuring that internal threads are prevented from rusting due to internal water inflow, internal instruments are rusted, and the blockage between the instruments is caused, thereby prolonging the service life of the instruments, reducing the maintenance cost, the uppermost first sliding block moves downwards under the pushing of the plugging piece, the folding piece is extruded, so that the waterproof film is bent, the water-resisting pieces on the two sides of the folding piece play a role in preventing liquid from entering from the two sides of the folding piece, the rusting of the internal instruments is avoided in the same way, the first elastic piece is extruded in the process, and finally the folding piece is pressed to be horizontal and embedded in the grooves at the upper end and the lower end of the first sliding block, the accommodation is completed, at the moment, the stirring blades and the stirring blades are in a close fit state, namely, the accommodation state is completed, the space is effectively saved, and the accommodation of the mode forms a whole body between the stirring blades, when the stirring blades are impacted by external force, the acting force can be dispersed, the phenomenon that the stirring blades touch other objects to be damaged in the process of uncovering after the accommodation is carried out is avoided, and when the stirring shaft is opened, the stirring blades are uniformly dispersed, so that the longitudinal area of the stirring is increased, the stirring is more uniform, meanwhile, in the first through grooves on the two adjacent stirring blades, the directions of the guide plates are different, when the stirring blades carry out rotary stirring, water flow not only passes through the upper parts of the stirring blades, but also passes through the first through grooves, so that the impact between two water flows is formed, the directions of the guide plates of the two adjacent groups are different, so that in the rotating process of the stirring blades, the inclination of the stirring blades drives the water flow to move upwards, promote rivers and carry out the circulation of certain degree in jar internal portion with this, thereby make the stirring more even, the bottom is more difficult to remain there is the sediment, it is also more even to be heated in the heating process, one of them is a set of will outwards to be dialled in the mode of rotatory in-process rivers with guide plate slope and is dispersed, another set of will play the effect of gathering together with the direction opposite to it in the stirring process, so will upwards move with curved mode between two adjacent stirring leaves at rivers, path length has been increased, the collision chance of rivers has been increased simultaneously, thereby the holistic stirring effect of equipment has been strengthened, make the enzymolysis process more even, make the utilization ratio of material more increase.

The adjusting structure comprises a wheel body arranged at the other end of the connecting rod, a first convex tooth arranged on the wheel body, a first clamping port arranged on the wheel body, a rack fixedly connected to the first sliding block, a first clamping block fixedly connected to the rack, and a torsion piece sleeved on the connecting rod; when the stirring shaft begins to shrink, the first sliding blocks are close to each other, the racks are meshed with the first convex teeth in the process of closing, so that the racks move to drive the wheel bodies to rotate, the wheel bodies are connected with the stirring blades through the connecting rods, the inclined stirring blades are flatly placed in a horizontal state by the rotation of the wheel bodies, the first clamping blocks are clamped in the first clamping ports to fix the stirring blades, the stirring shafts are stacked in a horizontal mode, the occupied space of the stirring blades is further reduced, the collision between the stirring blades and the second stirring shaft in the storage process is reduced, the maintenance cost is reduced, the distance of the farthest points in the turning process is effectively reduced in the process of taking out the turnover cover, the first through grooves are spliced with each other when the stirring shafts are stacked, and the first through grooves are spliced with each other, the lateral wall forms a vertical plane, so when wasing, has reduced the remaining of material residue and has made things convenient for the washing, and the setting of twist reverse makes the stirring leaf have certain upset ability, can bear the power that exceeds certain limit and make, carries out the upset of certain degree, avoids causing the damage to the stirring leaf to the maintenance cost of equipment has been reduced.

The rotation stopping structure comprises a first accommodating cavity arranged on the first stirring shaft, a first rotation stopping block arranged in the first accommodating cavity, a second elastic piece arranged below the first accommodating cavity and used for resetting the first rotation stopping block, a first pressing block arranged on the first rotation stopping block, a second accommodating cavity arranged on the second stirring shaft, a second rotation stopping block arranged in the second accommodating cavity, and a third elastic piece arranged in the second accommodating cavity and used for resetting the second rotation stopping block, the second pressing block is arranged at the upper end of the second rotation stopping block, the third pressing block is arranged at the lower end of the second rotation stopping block, the fourth pressing block is arranged on the third stirring shaft, the one-way teeth are arranged in the fixing groove, the third accommodating cavity is formed in the first rotation stopping block, the third rotation stopping block is arranged in the third accommodating cavity, and the fourth elastic piece is arranged in the third accommodating cavity and used for resetting the third rotation stopping block; when the stirring shaft extends outwards, the fourth pressing block extrudes the third pressing block to pull the second rotation stopping block to move downwards, the second pressing block arranged on the second rotation stopping block extrudes the first pressing block to move downwards so as to control the first rotation stopping block to move downwards, the structure effectively ensures that the first stirring shaft can rotate only when the stirring shaft is in a limit state, when the third stirring shaft does not reach the tail end of the second stirring shaft, the second rotation stopping block is lifted upwards due to the support of the third elastic part, even if the second stirring shaft moves to the tail end of the first stirring shaft, the second rotation stopping block can not extrude and move the first rotation stopping block, the stirring shaft is ensured to be in a rotation stopping state all the time in the extending process through the structure, so that the stable extension and contraction of the stirring shaft are ensured, when the length of the stirring shaft extends to the limit, the first rotation stopping block moves downwards, the third on the first end commentaries on classics piece is outwards popped out, the joint is in the position that the first end commentaries on classics piece was originally, be provided with the inclined plane on the third end commentaries on classics piece, so the third end commentaries on classics piece has played the effect of restriction (mixing) shaft unidirectional movement, when the (mixing) shaft stirs, the third end commentaries on classics piece will be owing to the inclined plane is inside to be withdrawn, and when needs withdraw the (mixing) shaft, the counter-rotating in-process, the third end commentaries on classics piece will play fixed action, thereby effectively guaranteed the stability of apparatus, the stability of (mixing) shaft in the use has been guaranteed.

The first auxiliary structure comprises a first support arranged on the inner wall of the stirring cavity, a first flow guide ring arranged on the first support, a second support arranged on the inner wall of the stirring cavity, a second flow guide ring arranged on the second support, and a chute arranged on the first flow guide ring; under the stirring action of the stirring shaft, more solution is scattered in a mode of diffusing towards the periphery and then collides with the first guide ring and the second guide ring, water flow collides with each other at the junction of the first guide ring and the second guide ring, at the moment, the second guide ring plays a role of guiding, the water flow impacts towards the first guide ring along the second guide ring, and collides with the first guide ring firstly when impacting on the first guide ring, and then the solution gathers towards the circle center along the first guide ring along the direction of the first guide ring, so that better collision among the solution is achieved, the solution in the inner part is more uniform, meanwhile, the structure can effectively assist the stirring blades to gather, so that the solution rises in a broken-line-shaped mode in the rising process, the collision is effectively increased in the broken-line-shaped rising mode, and a good mixing effect is achieved, and the liquid that is carried the top by the stirring leaf will have partly will laminate the stirring chamber lateral wall in the in-process that descends, lead by first water conservancy diversion ring, thereby hug closely the lateral wall whereabouts, this partial water of this in-process will obtain better heating, get into the vortex that is taken up by the stirring leaf afterwards, thereby the uniformity of inside temperature has been guaranteed, and have a small amount of partly will be along with ascending big upward movement of flow direction under the ascending impact of stirring leaf stirring in-process, this process will make first water conservancy diversion ring of each group and second water conservancy diversion ring all can form a less circulation circle, the whole big circulation circle that circulates with boiling form in the cooperation, constantly collide with constantly between the two and constantly the even degree that the flow will effectual improvement its solution, thereby the efficiency of reaction has been guaranteed.

The discharging structure comprises a flow guide surface arranged at the bottom of the stirring cavity, a holding tank arranged at the bottom of the stirring cavity, a rotating block rotatably arranged in the holding tank, a filter screen arranged at the bottom of the rotating block, a scraping sheet arranged on the rotating block, a material lifting slope arranged on the scraping sheet, an extrusion slope arranged below the scraping sheet, a convex block arranged below the scraping sheet, a transmission block arranged on the third stirring shaft and a second auxiliary structure arranged below the stirring cavity; when the stirring shaft extends to the limit position, the transmission block is clamped at one side of the scraping blade, so that the rotation of the stirring shaft drives the rotation block to rotate, the scraping blade is driven to continuously scrape the flow guide surface, the precipitation of meat residues is avoided, the reaction effect is enhanced, the preparation efficiency is improved, the utilization rate of raw materials is enhanced, most of the materials move upwards along the material lifting slope under the rotation of the scraping blade in the rotating process, then the materials are circularly captured by the solution carried by the stirring blades and enter the circulating process, small residues or tiny residues are not easily captured by the material lifting slope, if the bottom scraping mode is adopted, the scraping blade can scrape the flow guide surface to different degrees, the abrasion of instruments is caused, the maintenance cost is increased, the small materials of an individual body can pass through the extrusion slope below, and meanwhile, the longitudinal section through which water flows is slightly reduced due to the existence of the convex blocks, at the moment, the flow velocity below the extrusion inclined plane is larger than the normal flow velocity above the extrusion inclined plane, the material is driven by high flow velocity to move backwards, and at the moment of finally separating from the scraping plate, the material is lifted, so as to move upwards, and is lifted upwards by the scraping plate through which the lower block passes, and enters into solution circulation, so that the solution is stirred more uniformly, and the utilization rate is higher; after the (mixing) shaft contracts back, third (mixing) shaft below will be followed and extended in the rotary block, and solution will be poured into towards the rotary block this moment to filter through the filter screen, the residue will be preserved on the filter screen, after the (mixing) shaft extension resets, can take off the filter screen of below, thereby collect the residue and carry out effective utilization, the collection mode of residue is more convenient.

The second auxiliary structure comprises an air cavity arranged below the stirring cavity, a plurality of through holes communicated with the air cavity and the stirring cavity, a first one-way valve arranged in the through holes, a spiral track arranged in the through holes and an air supply structure arranged below the air cavity; through the continuous air supply of the air supply structure, the air is continuously accumulated in the air cavity, the accumulated air reaches a certain degree and then is sent out from the first one-way valve in the through hole and moves upwards along the spiral track, meanwhile, the air in the air cavity is continuously heated by the water bath heating of the first cavity, the air in the air cavity is continuously increased in air pressure after being heated due to the fact that the temperature of the air conveyed in is low, the water bath heating plays a role in pressurization, the air in the air cavity is always cold air with low temperature, the heating and pressurization effect always exists, the state of air pressure balance cannot be achieved, the pressurization effect of the thermodynamic energy is effectively utilized, in the process of moving upwards through the spiral track, due to the extrusion of the spiral track, the air bubbles rotate under the extrusion condition, and the bubbles which rotate and rise do spiral rising, thereby stir the solution of inside to the rising in-process of bubble will be caught by the guide plate through the guide plate on the stirring leaf, and the rising of bubble removes, will be along guide plate rebound, and the in-process of moving up will clear up the residue on the guide plate, thereby avoids the residue card to die the reaction effect of having guaranteed the material between the guide plate, thereby has increased final preparation effect.

The air supply structure comprises a second cavity arranged below the air cavity, a support ring sleeved on the rotating block, an extrusion block arranged on the connecting ring, a second through groove arranged at the bottom of the second cavity, a second rotating piece arranged on the side wall of the second through groove, a first block arranged on the second rotating piece, a third cavity arranged on the top wall of the second cavity, a rotating plate arranged in the third cavity, a second clamping groove arranged on the first block, a round angle arranged on the extrusion block, an oblique angle arranged on the extrusion block, a second one-way valve arranged on the top wall of the second cavity and a fixing structure arranged below the second cavity; the supporting block plays a role of supporting the rotating block, the rotating block drives the extrusion block to continuously move when rotating, the rotating plate is clamped in the second clamping groove on the first block, the first block fixes the rotating plate, a closed structure is formed inside the first block at the moment, air in the closed structure is extruded along with the movement of the extrusion block, the air enters the upper air cavity from the second one-way valve through the second one-way valve, air pressure is supplemented to the upper air cavity, the first block is extruded to rotate around the second rotating part when the extrusion block moves to a limit position, the rotating plate is moved out of the second clamping groove in the rotating process of the first block, the rotating plate is overturned upwards under the action of the extrusion block at the moment, a fillet arranged below the extrusion block extrudes the first block to rotate and is embedded into the third cavity to complete accommodation, the extrusion block is allowed to pass through after the extrusion block completely passes through, because the setting at extrusion piece rear oblique angle, the board resets with first block preferentially soon, first block upwards resets after the extrusion piece is complete through, the board joint once more gets into the second joint inslot of this moment, and first block is rotatory along the second rotating member, the second logical groove is exposed in resetting of first block afterwards, the event carries out the air supplement, be airtight state on the extrusion piece moving direction promptly, be the state of ventilating on the moving direction is reversed, after the extrusion piece passes through first block, first block resets after airtight once more, the rotation of (mixing) shaft will effectively be utilized in setting through this structure, the energy-concerving and environment-protective of consumption of the energy has been reduced, its air feed effect has been guaranteed simultaneously, inside stirring effect has been guaranteed, the stirring quality has been promoted.

The fixing structure comprises a fourth cavity arranged below the second cavity, a second sliding block arranged in the fourth cavity, a fifth elastic piece arranged in the fourth cavity and used for resetting the second sliding block, a second clamping port arranged on the second sliding block, a third through groove arranged on the top wall of the fourth cavity, a third sliding block capable of moving back and forth in the third through groove, and an extrusion angle arranged above the third sliding block; when the extrusion block is in an air extrusion state, the second sliding block is extruded by the fifth elastic piece to extend out of the fourth cavity, thereby the second sliding block plays a role of supporting and locking the first block body, the first block body is in a fixed state, the first block body can be ensured to play a good fixing role with the rotary plate, the gas can not be injected into the gas cavity due to gas leakage is avoided, when the extrusion roller is continuously close to the first block body, the extrusion block extrudes the extrusion angle on the third slide block and the third slide block moves downwards when reaching the tail end position, so that the second slide block is extruded by the second clamping interface and moves towards the inside of the fourth cavity body, the locking of the first block body is unlocked, and the first block body is in a free rotation state at the moment, so that the extrusion block passes through, the arrangement of the structure effectively ensures the stability of the first block body before the extrusion block moves to the limit position, so that the air quantity provided by the structure is more stable.

According to the invention, through the arrangement of the telescopic stirring structure, the stirring shaft can be contracted after stirring is finished, and the stirring shaft is opened in a turnover cover mode, so that the design height of the tank body is higher, the floor area is reduced, the accommodating volume of equipment is increased, and the interior is more convenient to clean; meanwhile, the heating efficiency is effectively guaranteed in a side wall heating mode, the internal temperature balance is guaranteed, and meanwhile the preparation efficiency is improved.

Drawings

FIG. 1 is a schematic structural diagram of the present invention.

Fig. 2 is a right side view of the present invention.

Fig. 3 is a schematic perspective cross-sectional view taken along line a-a of fig. 2.

Fig. 4 is an enlarged schematic view of a portion a of fig. 3.

Fig. 5 is an enlarged schematic view of fig. 3 at B.

Fig. 6 is a front view of the present invention.

Fig. 7 is a perspective cross-sectional view of fig. 6 taken along line B-B.

Fig. 8 is a partially enlarged schematic view of fig. 7.

Fig. 9 is a partially enlarged schematic view of fig. 8.

Fig. 10 is a cross-sectional view of fig. 6 taken along line C-C.

Fig. 11 is an enlarged schematic view of fig. 10.

Fig. 12 is a cross-sectional view of fig. 6 taken along line D-D.

Fig. 13 is a partially enlarged schematic view of fig. 12.

Fig. 14 is an enlarged schematic view of the knob.

Fig. 15 is a front view of the knob.

Detailed Description

As shown in fig. 1-15, a heparin sodium production device based on a secondary enzymolysis method comprises a cylinder body 1, support legs 2, a stirring device 3, a cover plate 4, a first rotating member 41 and a detection structure 8; the barrel is of a high-narrow barrel structure, the support legs 2 are arranged below the barrel, the stirring device 3 is arranged in the barrel, the cover plate 4 is arranged above the barrel, the first rotating piece 41 is used for connecting the barrel and the cover plate and is of a hinged structure and used for hinging the cover plate and the barrel, and the detection structure 8 is arranged on one side of the barrel, wherein the detection structure is the prior art and is an existing conventional means and is not repeated; the stirring device 3 comprises a stirring cavity 31, a first cavity 32, a heating pipe 33, a motor 34, a telescopic stirring structure 5, a first auxiliary structure 6 and a discharging structure 7; stirring chamber 31 is seted up in the barrel, first cavity 32 is seted up in the barrel inner wall, for setting up the cavity in barrel circumference a week, heating pipe 33 is located in the first cavity, motor 34 is located on the apron, the heating pipe with the motor is the prior art that can directly purchase the acquisition on the market, and the repeated description is no longer repeated here, and flexible stirring structure 5 is located the apron below, first auxiliary structure 6 is located on the stirring chamber lateral wall, ejection of compact structure 7 is located stirring chamber bottom.

As shown in fig. 3-4, 7-8 and 12, the telescopic stirring structure 5 includes a first stirring shaft 51, a fixing groove 52, a second stirring shaft 53, a first guide groove 54, a first opening 55, a third stirring shaft 56, a second guide groove 57, a second opening 58, a threaded rod 59, a first sleeve 510, a second sleeve 511, a stirring blade structure 9 and a rotation stopping structure 14; the first stirring shaft 51 is arranged below the cover plate and is of a cylindrical structure, the fixing groove 52 is used for fixing the first stirring shaft on the cover plate and is of a T-shaped groove structure, the second stirring shaft 53 can move back and forth in the first stirring shaft, the first guide groove 54 is arranged on the first stirring shaft, the first opening 55 is arranged on the second stirring shaft, a plurality of second stirring shafts can be arranged on the second stirring shaft, the length of the stirring shafts can be effectively increased, the length of the retracted stirring shafts is kept, the third stirring shaft 56 can move back and forth in the second stirring shaft, the second guide groove 57 is arranged on the inner wall of the second stirring shaft, the second opening 58 is arranged on the third stirring shaft, the guide grooves and the openings are matched with each other, so that the stirring shafts can only move back and forth in the axial direction and cannot rotate relatively, the threaded rod 59 is arranged on the motor, the first sleeve 510 is sleeved on the threaded rod, and threads are arranged inside and outside the first sleeve; one end of a second sleeve 511 is fixedly connected to the bottom of the third stirring shaft, and the inner wall of the second sleeve is provided with threads; the second sleeve is sleeved on the first sleeve; the stirring blade structure 9 is arranged on the second stirring shaft and the third stirring shaft, and the rotation stopping structure 14 is arranged on the cover plate.

As shown in fig. 3-4, the stirring vane structure 9 includes a first sliding groove 91, a first sliding block 92, a groove 93, a waterproof film 94, a folding sheet 95, a water-stop sheet 96, a first elastic member 97, a blocking sheet 98, a connecting rod 99, a stirring vane 910, a first through groove 911, a guide plate 912, and an adjusting structure 10; the first sliding groove 91 is arranged on the second stirring shaft and the third stirring shaft, the first sliding block 92 is provided with a plurality of blocks arranged in the first sliding groove, the groove 93 is arranged on the first sliding block, the waterproof film 94 is connected with two adjacent first sliding blocks, the waterproof film adopts rubber sheets made of rubber materials and can be made of other materials, the folding sheets 95 are arranged in the groove and are two sheet bodies which can be turned over, the water-proof sheets 96 are arranged on two sides of the folding sheets and are arranged on two sides of the folding sheets for sealing two sides of the folding sheets, the first elastic piece 97 is arranged on the folding sheets, the first elastic piece is a spring, the blocking sheets 98 are sleeved on the second stirring shaft and the third stirring shaft and are of an annular structure, two convex blocks are arranged on the blocking sheets and are clamped in the first sliding groove, and the water flow blocking effect is achieved, the connecting rod 99 penetrates through the first sliding block, the stirring blade 910 is fixedly connected to one end of the connecting rod, the stirring blade is arranged in an inclined mode, when the stirring blade plays a stirring role, water flow is driven to move upwards, the first through groove 911 is formed in the stirring blade, the first through groove is vertically formed in the stirring blade, a plurality of guide plates 912 are arranged in the first through groove, and the guide plates form a certain angle with the vertical direction; the guide plates arranged on two adjacent stirring blades are opposite in inclination direction, and the adjusting structure 10 is arranged on the first sliding block.

As shown in fig. 12-13, the adjusting structure 10 includes a wheel body 101, a first tooth 102, a first engaging opening 103, a rack 104, a first engaging block 105, and a twisting member 106; wheel body 101 is located the connecting rod other end, first dogtooth 102 is seted up in on the wheel body, first joint mouth 103 is seted up in on the wheel body, first dogtooth and first joint mouth all set up two of the symmetry setting on the wheel body, rack 104 link firmly in on the first slider, first joint piece 105 link firmly on the rack, torsion member 106 cover is located on the connecting rod, torsion member here sets up to the torsional spring.

As shown in fig. 8-9, the rotation stopping structure 14 includes a first accommodating cavity 141, a first rotation stopping block 142, a second elastic member 143, a first pressing block 144, a second accommodating cavity 145, a second rotation stopping block 146, a third elastic member 147, a second pressing block 148, a third pressing block 149, a fourth pressing block 1410, a third accommodating cavity 1411, a third rotation stopping block 1412 and a fourth elastic member 1413; a first containing cavity 141 is arranged on the first stirring shaft, a first rotation stopping block 142 is arranged in the first containing cavity, a second elastic piece 143 is arranged below the first containing cavity and used for resetting the first rotation stopping block, a first pressing block 144 is arranged on the first rotation stopping block, a second containing cavity 145 is arranged on the second stirring shaft, a second rotation stopping block 146 is arranged in the second containing cavity, a third elastic piece 147 is arranged in the second containing cavity and used for resetting the second rotation stopping block, a second pressing block 148 is arranged at the upper end of the second rotation stopping block, a third pressing block 149 is arranged at the lower end of the second rotation stopping block, a fourth pressing block 1410 is arranged on the third stirring shaft, a third containing cavity 1411 is arranged on the first rotation stopping block, a third rotation stopping block 1412 is arranged in the third containing cavity, and a fourth elastic piece 1413 is arranged in the third containing cavity and used for resetting the third rotation stopping block, the second elastic member, the third elastic member and the fourth elastic member are all provided as springs.

As shown in fig. 7, the first auxiliary structure 6 includes a first bracket 61, a first guide ring 62, a second bracket 63, a second guide ring 64, and an inclined groove 65; the first support 61 is arranged on the inner wall of the stirring cavity, the first guide ring 62 is arranged on the first support, the second support 63 is arranged on the inner wall of the stirring cavity, the second guide ring 64 is arranged on the second support, the chute 65 is arranged on the first guide ring, the first guide ring and the second guide ring form a structure similar to a V shape, but the tail end of the second guide ring faces the tail end of the first guide ring.

As shown in fig. 3 and 14-15, the discharging structure 7 includes a flow guide surface 71, a receiving groove 72, a rotating block 73, a filter screen 74, a scraping blade 75, a material lifting slope 76, an extrusion slope 77, a protrusion 78, a transmission block 79, and a second auxiliary structure 11; flow guide face 71 is located stirring chamber bottom, holding tank 72 set up in stirring chamber bottom, change piece 73 rotatable set up in the holding tank, filter screen 74 is located change piece bottom, the filter screen is detachable construction, and doctor-bar 75 locates on the change piece, lift material slope 76 locates on the doctor-bar, extrusion slope 77 locates the doctor-bar below, lug 78 locates the doctor-bar below, the lug is provided with polylith parallel arrangement, and drive block 79 locates on the third (mixing) shaft, second auxiliary structure 11 locates stirring chamber below.

As shown in fig. 3 and 5, the second auxiliary structure 11 includes an air cavity 111, a through hole 112, a first one-way valve 113, a spiral track 114, and an air supply structure 12; air cavity 111 is seted up in stir chamber below, through-hole 112 is provided with a plurality ofly, evenly distributed and air cavity top, communicate in the air cavity with stir the chamber, first check valve 113 is located in the through-hole, first check valve is not repeated here for prior art, and spiral track 114 is located in the through-hole, air feed structure 12 is located the air cavity below.

As shown in fig. 11 and 14, the gas supply structure 12 includes a second cavity 121, a support ring 122, an extrusion block 123, a second through slot 124, a second rotating member 125, a first block 126, a third cavity 127, a rotating plate 128, a second clamping groove 129, a rounded corner 1210, a bevel 1211, a second one-way valve 1212, and a fixing structure 13; the second cavity 121 is arranged below the air cavity, the support ring 122 is sleeved on the rotating block, the extrusion block 123 is arranged on the connecting ring, the second through groove 124 is arranged at the bottom of the second cavity, the second rotating piece 125 is arranged on the side wall of the second through groove, the first block 126 is arranged on the second rotating piece, the third cavity 127 is arranged on the top wall of the second cavity, the rotating plate 128 is arranged in the third cavity, the second clamping groove 129 is arranged on the first block, the round corner 1210 is arranged on the extrusion block, the bevel 1211 is arranged on the extrusion block, the second check valve 1212 is arranged on the top wall of the second cavity, and the fixing structure 13 is arranged below the second cavity.

As shown in fig. 11, the fixing structure 13 includes a fourth cavity 131, a second slider 132, a fifth elastic element 133, a second clip interface 134, a third through groove 135, a third slider 136, and an extrusion angle 137; the fourth cavity 131 is arranged below the second cavity, the second slider 132 is arranged in the fourth cavity, the fifth elastic piece 133 is arranged in the fourth cavity and used for resetting the second slider, the second clamping interface 134 is arranged on the second slider, the third through groove 135 is arranged on the top wall of the fourth cavity, the third slider 136 can move back and forth in the third through groove, and the extrusion angle 137 is arranged above the third slider.

The specific operation flow is as follows:

putting all raw materials into a barrel body 1, then rotating a cover plate 4 around a first rotating piece 41 so as to close, heating the interior of the barrel body by a heating pipe 33, starting a motor 34 to rotate, driving a threaded rod 59 to rotate by the rotation of the motor, matching a first stirring shaft 51 and a second stirring shaft 53 with a first opening 55 through a first guide groove 54 at the moment, limiting the second stirring shaft by the first guide groove on the first stirring shaft, being in a static state relative to the first stirring shaft and only moving up and down, matching a second guide groove with a second opening between the second stirring shaft and a third stirring shaft 56 to be in a similar way, so that a second sleeve 511 is in a static state relative to the third stirring shaft, driving the first sleeve 510 to rotate when the threaded rod rotates, driving the first sleeve to rotate, and matching the second sleeve with the first sleeve thread, thereby driving the second sleeve to move downwards, or driving the first sleeve to move downwards through the matching between the screw threads, both the two sequences are possible, in the moving process, the first slide blocks are separated from each other, the first elastic piece controls the folding piece 95 to open, thereby the stirring blades 910 are separated from each other, because of the movement between the rack 104 and the first convex tooth 102, the first clamping block 105 moves out from the first clamping port 103, at the moment, the stirring blades turn over to form a certain angle, in the extending process of the stirring shaft, the fourth pressing block 1410 presses the third pressing block 149, thereby pulling the second rotation stopping block 146 to move downwards, the second pressing block 148 arranged on the second rotation stopping block presses the first pressing block to move downwards, thereby controlling the first rotation stopping block 142 to move downwards, the structure effectively ensures that the first stirring shaft can only rotate when the first stirring shaft is in the limit state, when the first sleeve and the second sleeve both extend to the limit, at the moment, the rotation of the threaded rod drives the whole stirring rod to rotate, so that the inside of the stirring rod is stirred, at the moment, the transmission block is clamped on one side of the scraping blade 75, the rotation of the stirring shaft drives the rotating block 73 to rotate, the scraping blade is driven to continuously scrape the flow guide surface 71, the precipitation of meat slag is avoided, the reaction effect is enhanced, the preparation efficiency is improved, the utilization rate of raw materials is enhanced, most of the materials move upwards along the material lifting slope 76 under the rotation of the scraping blade in the rotating process, then the materials are circularly captured by the solution carried by the stirring blades to enter the circulating process, smaller materials pass through the extrusion inclined surface 77 below the extrusion inclined surface, meanwhile, due to the existence of the convex block 78, the longitudinal section through which water flows is slightly reduced, the flow rate below the extrusion inclined surface is larger than the normal flow rate above, the materials move backwards under the driving of high flow rate, and finally separate from the scraping blade, the material will be lifted up, thereby move upwards, and is upwards brought up by the scraper blade that the lower piece passes through, get into among the solution circulation, liquid will be under the effect of stirring, move upwards, in the first logical inslot on two adjacent stirring leaves, the guide plate direction is different, when the stirring leaf carries out rotatory stirring, rivers not only pass through the top of stirring leaf, pass through first logical groove 91 simultaneously, thereby form the impact between two strands of rivers, adjacent two sets of guide plate 912 direction is different, can be in the rotatory in-process of stirring leaf, the slope setting of stirring leaf will drive rivers upwards to move, so as to promote rivers to carry out certain degree of circulation in jar internal portion, thereby make the stirring more even, the bottom is more difficult to remain deposits, it is also more even to heat in the heating process, and form miniature circulation structure in first water conservancy diversion ring 62 and second water conservancy diversion ring 64 department through this ascending rivers, when the rotating block rotates, the extrusion block 123 is driven to move continuously, the rotating plate 128 is clamped in the second clamping groove 129 on the first block 126, the first block fixes the rotating plate, at the moment, a closed structure is formed inside the first block, air in the closed structure is extruded along with the movement of the extrusion block, so that the air enters the air cavity above the second check valve 1212, air pressure is supplemented to the air cavity above the first block, when the extrusion block moves to a limit position, the first block is extruded to rotate around the second rotating part, the rotating plate moves out of the second clamping groove in the rotating process of the first block, the rotating plate turns upwards under the action of the extrusion block, a fillet arranged below the extrusion block extrudes the first block to rotate, the first block is embedded into the third cavity 127 to complete accommodation, then the extrusion block is allowed to pass through the opening, after the extrusion block completely passes through the opening, due to the arrangement of the rear oblique angle 1211 of the extrusion block, the rotary plate is preferentially reset with the first block, when the extrusion block completely passes through the first block, the first block is reset upwards, the rotary plate is clamped into the second clamping groove again, the first block rotates along the second rotating piece, the first block is reset to expose the second through groove 124, air is supplemented, air is continuously accumulated in the air cavity, the accumulated air is sent out from the first one-way valve in the through hole after reaching a certain degree and moves upwards along the spiral track 114, stirring is enhanced, enzymolysis is performed, after the enzymolysis is finished, the click is reversed, the third rotation stopping block 1412 plays a role in fixing the first stirring shaft, the stirring shaft is controlled to ascend, the lower part of the third stirring shaft extends out from the inside of the rotary block, the solution is poured into the rotary block, filtering is performed through the filter screen, and residues are retained on the filter screen, after the extension of (mixing) shaft resets, can take off the filter screen of below to collect the residue and carry out effective utilization, can open the apron this moment, repeat above-mentioned flow.

While there have been shown and described what are at present considered the fundamental principles and essential features of the invention and its advantages, it will be apparent to those skilled in the art that the invention is not limited to the details of the foregoing exemplary embodiments, but is capable of other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims

1. A heparin sodium production device based on a secondary enzymolysis method comprises a cylinder body (1), support legs (2) arranged at the bottom of the cylinder body, a stirring device (3) arranged in the cylinder body, a cover plate (4) arranged above the cylinder body, a first rotating piece (41) used for connecting the cylinder body and the cover plate, and a detection structure (8) arranged on one side of the cylinder body; the method is characterized in that: the stirring device (3) comprises a stirring cavity (31) arranged in the barrel, a first cavity (32) arranged on the inner wall of the barrel, a heating pipe (33) arranged in the first cavity, a motor (34) arranged on the cover plate, a telescopic stirring structure (5) arranged below the cover plate, a first auxiliary structure (6) arranged on the side wall of the stirring cavity and a discharging structure (7) arranged at the bottom of the stirring cavity;

the telescopic stirring structure (5) comprises a first stirring shaft (51) arranged below the cover plate, a fixing groove (52) used for fixing the first stirring shaft on the cover plate, a second stirring shaft (53) capable of moving back and forth in the first stirring shaft, a first guide groove (54) arranged on the first stirring shaft, a first opening (55) arranged on the second stirring shaft, a third stirring shaft (56) capable of moving back and forth in the second stirring shaft, a second guide groove (57) arranged on the inner wall of the second stirring shaft, a second opening (58) arranged on the third stirring shaft, a threaded rod (59) arranged on the motor, a first sleeve (510) sleeved on the threaded rod, and a stirring blade structure (9) arranged on the second stirring shaft and the third stirring shaft, wherein one end of the first sleeve (511) is fixedly connected to the bottom of the third stirring shaft, A rotation stopping structure (14) arranged on the cover plate; threads are arranged on the inner side and the outer side of the first sleeve; the inner wall of the second sleeve is provided with threads; the second sleeve is sleeved on the first sleeve;

the stirring blade structure (9) comprises a first sliding groove (91) arranged on the second stirring shaft and the third stirring shaft, a plurality of first sliding blocks (92) arranged in the first sliding grooves, a groove (93) arranged on the first sliding blocks, waterproof films (94) connected with two adjacent first sliding blocks, folding pieces (95) arranged in the grooves, water-proof pieces (96) arranged on two sides of the folding pieces, and first elastic pieces (97) arranged on the folding pieces, the second stirring shaft and the third stirring shaft are sleeved with blocking pieces (98), a connecting rod (99) penetrates through the first sliding block, a stirring blade (910) fixedly connected to one end of the connecting rod, a first through groove (911) formed in the stirring blade, a plurality of guide plates (912) arranged in the first through groove, and an adjusting structure (10) arranged on the first sliding block; the guide plate forms a certain angle with the vertical direction; the guide plates arranged on two adjacent stirring blades are opposite in inclination direction;

ejection of compact structure (7) including locating water conservancy diversion face (71) of stirring chamber bottom, set up in holding tank (72) of stirring chamber bottom, rotatable set up in change piece (73) in the holding tank, locate change filter screen (74) of piece bottom, locate change doctor-bar (75) on the piece, locate lift material slope (76) on the doctor-bar, locate extrusion slope (77) of doctor-bar below, locate lug (78) of doctor-bar below, locate epaxial transmission piece (79) of third stirring, locate second auxiliary structure (11) of stirring chamber below.

2. The heparin sodium production equipment based on the secondary enzymolysis method as claimed in claim 1, wherein: the adjusting structure (10) comprises a wheel body (101) arranged at the other end of the connecting rod, a first convex tooth (102) arranged on the wheel body, a first clamping port (103) arranged on the wheel body, a rack (104) fixedly connected to the first sliding block, a first clamping block (105) fixedly connected to the rack, and a torsion piece (106) sleeved on the connecting rod.

3. The heparin sodium production equipment based on the secondary enzymolysis method as claimed in claim 1, wherein: the rotation stopping structure (14) comprises a first accommodating cavity (141) arranged on the first stirring shaft, a first rotation stopping block (142) arranged in the first accommodating cavity, a second elastic piece (143) arranged below the first accommodating cavity and used for resetting the first rotation stopping block, a first pressing block (144) arranged on the first rotation stopping block, a second accommodating cavity (145) arranged on the second stirring shaft, a second rotation stopping block (146) arranged in the second accommodating cavity, a third elastic piece (147) arranged in the second accommodating cavity and used for resetting the second rotation stopping block, a second pressing block (148) arranged at the upper end of the second rotation stopping block, a third pressing block (149) arranged at the lower end of the second rotation stopping block, a fourth pressing block (1410) arranged on the third stirring shaft, a third accommodating cavity (1411) arranged on the first rotation stopping block, a third rotation stopping block (1412) arranged in the third accommodating cavity, And a fourth elastic piece (1413) arranged in the third accommodating cavity and used for resetting the third rotation stop block.

4. The heparin sodium production equipment based on the secondary enzymolysis method as claimed in claim 1, wherein: the first auxiliary structure (6) comprises a first support (61) arranged on the inner wall of the stirring cavity, a first flow guide ring (62) arranged on the first support, a second support (63) arranged on the inner wall of the stirring cavity, a second flow guide ring (64) arranged on the second support and a chute (65) arranged on the first flow guide ring.

5. The heparin sodium production equipment based on the secondary enzymolysis method as claimed in claim 1, wherein: the second auxiliary structure (11) comprises an air cavity (111) arranged below the stirring cavity, a plurality of through holes (112) communicated with the air cavity and the stirring cavity, a first one-way valve (113) arranged in the through holes, a spiral track (114) arranged in the through holes, and an air supply structure (12) arranged below the air cavity.

6. The apparatus for producing heparin sodium based on the secondary enzymolysis method as claimed in claim 5, wherein: the air supply structure (12) comprises a second cavity (121) arranged below the air cavity, a support ring (122) sleeved on the rotating block, an extrusion block (123) arranged on the support ring, a second through groove (124) arranged at the bottom of the second cavity, a second rotating part (125) arranged on the side wall of the second through groove, a first block (126) arranged on the second rotating part, a third cavity (127) arranged on the top wall of the second cavity, a rotating plate (128) arranged in the third cavity, a second clamping groove (129) arranged on the first block, a round angle (1210) arranged on the extrusion block, an oblique angle (1211) arranged on the extrusion block, a second one-way valve (1212) arranged on the top wall of the second cavity and a fixing structure (13) arranged below the second cavity.

7. The apparatus for producing heparin sodium based on the secondary enzymolysis method as claimed in claim 6, wherein: fixed knot constructs (13) including seting up in fourth cavity (131) of second cavity below, locate second slider (132) in the fourth cavity, locate be used for restoring to the throne in the fourth cavity fifth elastic component (133) of second slider, set up in second joint interface (134) on the second slider, set up in third logical groove (135) on the fourth cavity roof, can third slider (136) of round trip movement in the third logical groove, locate extrusion angle (137) of third slider top.