CN112022978A - A Chinese medicinal granule for treating viral hepatitis, and its preparation method - Google Patents
A Chinese medicinal granule for treating viral hepatitis, and its preparation method Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine granule for treating viral hepatitis, which is prepared from the following raw materials in parts by weight: 16-26 parts of oriental wormwood, 12-26 parts of scutellaria baicalensis, 12-20 parts of yellow sweet clover, 10-20 parts of cape jasmine, 8-16 parts of desmodium, 12-16 parts of oldenlandia diffusa, 6-18 parts of lophatherum gracile and 3-9 parts of liquorice. The invention has the functions of clearing and activating the channels and collaterals, promoting diuresis and reducing edema, strengthening the liver and the stomach, tonifying the kidney and the spleen, nourishing yin and producing sperm, improving the immunity of the organism, clearing away heat and toxic materials, clearing away cold and dampness, removing RNA transfection caused by virus, and blocking the infection path of the virus from the root; is suitable for the conversion of big three positive to small three positive and small three positive to negative of hepatitis B, and has good curative effect on hepatitis A, hepatitis C and hepatitis E.
Description
Technical Field
The invention relates to the technical field of medicaments, in particular to a traditional Chinese medicine granule for treating viral hepatitis and a preparation method thereof.
Background
Viral hepatitis is an infectious disease mainly caused by liver diseases caused by various hepatitis viruses. Clinically, the symptoms of anorexia, nausea, epigastric discomfort, liver pain and hypodynamia are mainly manifested, and some patients can have jaundice fever and liver cirrhosis with liver function damage. Some patients can become chronic, even develop cirrhosis of the liver, and a few can develop liver cancer. The etiological typing of viral hepatitis is currently recognized by five hepatitis viruses, namely hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E virus, which are respectively written as HAV, HBV, HCV, HDV and HEV, and the rest are RNA viruses except the hepatitis B virus which is a DNA virus.
Although the number of antiviral drugs studied at home and abroad is close to 50 at present, only a few kinds of nucleoside drugs such as acyclovir, lamivudine and the like are really applied to clinic, and the drugs can only delay the growth of viruses or relieve the disease symptoms generally and have the serious defects of large toxic and side effects, high price, rebound medicine stopping and the like.
Disclosure of Invention
Aiming at the prior art, the invention aims to provide the traditional Chinese medicine granules for treating the viral hepatitis, and the traditional Chinese medicine granules have the functions of clearing and activating the channels and collaterals, promoting diuresis and reducing swelling, strengthening the liver and stomach, tonifying the kidney and strengthening the spleen, nourishing yin and producing sperm, improving the immunity of the organism, clearing away heat and toxic materials, eliminating dampness and cold, removing RNA transfection caused by viruses, and blocking the infection way of the viruses from roots. Is suitable for the conversion of big three positive to small three positive and small three positive to negative of hepatitis B, and has good curative effect on hepatitis A, hepatitis C and hepatitis E.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a traditional Chinese medicine granule for treating viral hepatitis, which is prepared from the following raw materials in parts by weight: 16-26 parts of oriental wormwood, 12-26 parts of scutellaria baicalensis, 12-20 parts of yellow sweet clover, 10-20 parts of cape jasmine, 8-16 parts of desmodium, 12-16 parts of oldenlandia diffusa, 6-18 parts of lophatherum gracile and 3-9 parts of liquorice.
Preferably, the feed additive comprises the following raw materials in parts by weight: 18-23 parts of oriental wormwood, 14-22 parts of scutellaria baicalensis, 14-18 parts of yellow sweet clover, 12-18 parts of cape jasmine, 10-14 parts of desmodium, 13-15 parts of oldenlandia diffusa, 8-16 parts of lophatherum gracile and 4-8 parts of liquorice.
Preferably, the feed additive comprises the following raw materials in parts by weight: 19-21 parts of oriental wormwood, 16-20 parts of scutellaria baicalensis, 15-16 parts of sweet clover, 14-16 parts of cape jasmine, 11-13 parts of lysimachia christinae hance, 14-15 parts of oldenlandia diffusa, 10-12 parts of lophatherum gracile and 5-7 parts of liquorice.
In a second aspect of the present invention, a preparation method of the above traditional Chinese medicine granule for treating viral hepatitis is provided, which comprises the following steps:
(1) adding ethanol into Melilotus officinalis, reflux-extracting at 90-95 deg.C for 2-3 hr, recovering ethanol, and filtering to obtain filtrate;
(2) mixing herba Artemisiae Scopariae, Scutellariae radix, fructus Gardeniae, herba Lysimachiae Christinae, herba Hedyotidis Diffusae, folium Bambusae and Glycyrrhrizae radix at a certain proportion, soaking in water, heating and decocting for 2-3 times, filtering, separating, collecting decoctions, and mixing;
(3) mixing the filtrate obtained in the step (1) and the decoction obtained in the step (2) to obtain a mixed solution, and concentrating the mixed solution to obtain an extract;
(4) and (4) carrying out spray drying and granulation on the extract obtained in the step (3).
Preferably, in the step (1), the solid-to-liquid ratio of meliloti to ethanol is 1g: (30-40) ml.
Preferably, in the step (1), the volume concentration of the ethanol is 70-80%.
Preferably, in the step (2), when the mixture is soaked in water, the solid-to-liquid ratio of the solid raw material to the water is 1g (10-12) ml, and the soaking time is 1 h.
Preferably, in the step (2), the time for each decoction is 20-30 min.
Preferably, in the step (3), the extract is concentrated to a relative density of 1.12-1.16 at 65 ℃.
Preferably, in the step (4), during spray drying, the air inlet temperature is 90-95 ℃, the material temperature is 62-65 ℃, and the air volume is 0.7-0.8m3Min, the feeding amount of the extract is 0.3-0.4 kg/min.
The invention has the beneficial effects that:
1. the invention has the functions of clearing and activating the channels and collaterals, promoting diuresis and reducing edema, strengthening the liver and the stomach, tonifying the kidney and the spleen, nourishing yin and producing sperm, improving the immunity of the organism, clearing away heat and toxic materials, clearing away cold and dampness, removing RNA transfection caused by virus, and blocking the infection path of the virus from the root; is suitable for the conversion of big three positive to small three positive and small three positive to negative of hepatitis B, and has good curative effect on hepatitis A, hepatitis C and hepatitis E.
2. The raw materials of the invention cooperate together under appropriate dosage, and cooperate with the preparation method, so that the obtained traditional Chinese medicine granule has good curative effect on hepatitis B, hepatitis A, hepatitis C and hepatitis E.
3. The invention can solve the problems of expensive medicine, great side effect and rebound medicine stopping of the existing western medicine for treating viral hepatitis.
Sweet clover: it is slightly sweet in taste, neutral in nature, and has effects of relieving cough and asthma, resolving hard mass and relieving pain, and can be used for treating asthma, bronchitis, intestinal colic, wound, and lymph node swelling and pain.
Herba artemisiae scopariae: it is bitter, pungent and slightly cold in flavor; spleen, stomach, liver and gallbladder meridians entered; has effects of clearing away dampness and heat, promoting bile flow, and eliminating jaundice. Can be used for treating jaundice, oliguria, damp warmth, summer dampness, eczema, and pruritus.
Scutellaria baicalensis: it is bitter and cold in taste. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. Has effects of clearing heat, eliminating dampness, clearing pathogenic fire, removing toxic substance, stopping bleeding, and preventing miscarriage. Can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness and heat distention, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.
Gardenia: it is bitter and cold in taste. It enters heart, lung and triple energizer meridians. Has the effects of purging pathogenic fire, relieving restlessness, clearing away heat, promoting diuresis, cooling blood, and removing toxic substances; has repercussive and analgesic effects. Can be used for treating febrile vexation, damp-heat jaundice, stranguria with pain, hematemesis, epistaxis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to fire toxin, and for treating sprain, contusion and pain.
Herba Lysimachiae Christinae: it is sweet, salty and slightly cold in taste. It enters liver, gallbladder, kidney and bladder meridians. Has effects of promoting diuresis, eliminating jaundice, promoting urination, treating stranguria, removing toxic substance and relieving swelling. Can be used for treating damp-heat jaundice, gallbladder distention, hypochondriac pain, stranguria with stone, stranguria with heat, difficulty and pain in urination, carbuncle, furuncle, and snake and insect bite.
Herba lophatheri: it is sweet, bland and cold in flavor. It enters heart, stomach and small intestine meridians. Has effects of clearing heat-fire, relieving restlessness, quenching thirst, inducing diuresis and treating stranguria. Can be used for treating fever, polydipsia, scanty and painful urine, and aphtha of the mouth and tongue.
Herba Hedyotidis Diffusae: it is bitter and bland in taste and cold in nature. The main effects are clearing away heat and toxic material, relieving pain and dissipating stagnation, and promoting urination and removing dampness.
Licorice root: it is sweet and mild in taste. It enters heart, lung, spleen and stomach meridians. Has the effects of invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, relieving spasm and pain, and harmonizing the medicines. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.
Detailed Description
It should be noted that the following detailed description is exemplary and is intended to provide further explanation of the disclosure. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs.
As introduced in the background art, the current western medicines for viral hepatitis only can delay the growth of viruses or relieve the disease symptoms, and have the serious defects of large toxic and side effects, high price, rebound after stopping taking medicine and the like.
Based on the above, the invention discloses a traditional Chinese medicine granule for treating viral hepatitis, the raw materials of the traditional Chinese medicine granule are cooperatively matched under proper dosage and are cooperatively prepared by a cooperative preparation method, so that the obtained traditional Chinese medicine granule has the functions of clearing and activating the channels and collaterals, promoting diuresis and reducing edema, strengthening the liver and stomach, tonifying the kidney and strengthening the spleen, nourishing yin and producing sperm, improving the immunity of the organism, clearing away heat and toxic materials, eliminating dampness and cold, removing RNA transfection caused by viruses, and blocking the infection path of the viruses from roots; is suitable for the conversion of big three positive to small three positive and small three positive to negative of hepatitis B, and has good curative effect on hepatitis A, hepatitis C and hepatitis E.
In order to make the technical solutions of the present application more clearly understood by those skilled in the art, the technical solutions of the present application will be described in detail below with reference to specific embodiments.
The test materials used in the examples of the present invention are all conventional in the art and commercially available.
Example 1: a traditional Chinese medicine granule for treating viral hepatitis comprises the following raw materials in parts by weight: 16 parts of oriental wormwood, 12 parts of scutellaria baicalensis, 12 parts of yellow sweet clover, 10 parts of cape jasmine, 8 parts of desmodium, 12 parts of spreading hedyotis herb, 6 parts of lophatherum gracile and 3 parts of liquorice.
The preparation method of the traditional Chinese medicine granule for treating viral hepatitis comprises the following steps:
(1) adding ethanol into Melilotus officinalis, reflux-extracting at 90 deg.C for 3 hr, recovering ethanol, and filtering to obtain filtrate; the solid-to-liquid ratio of meliloti to ethanol is 1g: 30 ml; the volume concentration of the ethanol is 70 percent;
(2) mixing herba Artemisiae Scopariae, Scutellariae radix, fructus Gardeniae, herba Lysimachiae Christinae, herba Hedyotidis Diffusae, folium Bambusae and Glycyrrhrizae radix at a certain proportion, soaking in water for 1h, wherein the solid-to-liquid ratio of the solid material to water is 1g:10 ml; then heating and decocting for 2 times, each time for 30min, filtering, separating, collecting each decoction, and mixing;
(3) mixing the filtrate obtained in the step (1) and the decoction obtained in the step (2) to obtain a mixed solution, concentrating the mixed solution to obtain an extract, and concentrating the extract until the relative density is 1.12 at 65 ℃;
(4) spray drying and granulating the extract obtained in the step (3), wherein the temperature of an air inlet is 90 ℃, the temperature of the material is 62 ℃, and the air volume is 0.7m during spray drying3Min, the feeding amount of the extract is 0.3 kg/min.
Example 2: a traditional Chinese medicine granule for treating viral hepatitis comprises the following raw materials in parts by weight: 26 parts of oriental wormwood, 26 parts of scutellaria baicalensis, 20 parts of yellow sweet clover, 20 parts of cape jasmine, 16 parts of desmodium, 16 parts of spreading hedyotis herb, 18 parts of lophatherum gracile and 9 parts of liquorice.
The preparation method of the traditional Chinese medicine granule for treating viral hepatitis comprises the following steps:
(1) adding ethanol into Melilotus officinalis, reflux-extracting at 95 deg.C for 2 hr, recovering ethanol, and filtering to obtain filtrate; the solid-to-liquid ratio of meliloti to ethanol is 1g: 40 ml; the volume concentration of the ethanol is 80 percent;
(2) mixing herba Artemisiae Scopariae, Scutellariae radix, fructus Gardeniae, herba Lysimachiae Christinae, herba Hedyotidis Diffusae, folium Bambusae and Glycyrrhrizae radix at a certain proportion, soaking in water for 1h, wherein the solid-to-liquid ratio of the solid material to water is 1g:12 ml; then heating and decocting for 3 times, each time for 20min, filtering, separating, collecting each decoction, and mixing;
(3) mixing the filtrate obtained in the step (1) and the decoction obtained in the step (2) to obtain a mixed solution, concentrating the mixed solution to obtain an extract, and concentrating the extract until the relative density is 1.16 at 65 ℃;
(4) spray drying and granulating the extract obtained in the step (3), wherein in the spray drying process, the air inlet temperature is 95 ℃, the material temperature is 65 ℃, and the air volume is 0.8m3Min, the feeding amount of the extract is 0.4 kg/min.
Example 3: a traditional Chinese medicine granule for treating viral hepatitis comprises the following raw materials in parts by weight: 20 parts of oriental wormwood, 20 parts of scutellaria baicalensis, 16 parts of yellow sweet clover, 15 parts of cape jasmine, 12 parts of desmodium, 14 parts of oldenlandia diffusa, 14 parts of lophatherum gracile and 6 parts of liquorice.
The preparation method of the traditional Chinese medicine granule for treating viral hepatitis comprises the following steps:
(1) adding ethanol into Melilotus officinalis, reflux-extracting at 92 deg.C for 2.5h, recovering ethanol, and filtering to obtain filtrate; the solid-to-liquid ratio of meliloti to ethanol is 1g: 35ml of the solution; the volume concentration of the ethanol is 80 percent;
(2) mixing herba Artemisiae Scopariae, Scutellariae radix, fructus Gardeniae, herba Lysimachiae Christinae, herba Hedyotidis Diffusae, folium Bambusae and Glycyrrhrizae radix at a certain proportion, soaking in water for 1h, wherein the solid-to-liquid ratio of the solid material to water is 1g:11 ml; then heating and decocting for 3 times, each time for 20min, filtering, separating, collecting each decoction, and mixing;
(3) mixing the filtrate obtained in the step (1) and the decoction obtained in the step (2) to obtain a mixed solution, concentrating the mixed solution to obtain an extract, and concentrating the extract until the relative density is 1.14 at 65 ℃;
(4) spray drying and granulating the extract obtained in the step (3), wherein the temperature of an air inlet is 92 ℃, the temperature of the material is 64 ℃, and the air volume is 0.78m during spray drying3Min, the feeding amount of the extract is 0.4 kg/min.
Comparative example 1: a traditional Chinese medicine granule for treating viral hepatitis comprises the following raw materials in parts by weight: 16 parts of oriental wormwood, 12 parts of scutellaria baicalensis, 10 parts of cape jasmine fruit, 8 parts of desmodium, 12 parts of oldenlandia diffusa, 6 parts of lophatherum gracile and 3 parts of liquorice.
The preparation method of the traditional Chinese medicine granule for treating viral hepatitis comprises the following steps:
(1) mixing herba Artemisiae Scopariae, Scutellariae radix, fructus Gardeniae, herba Lysimachiae Christinae, herba Hedyotidis Diffusae, folium Bambusae and Glycyrrhrizae radix at a certain proportion, soaking in water for 1h, wherein the solid-to-liquid ratio of the solid material to water is 1g:11 ml; then heating and decocting for 3 times, each time for 20min, filtering, separating, collecting each decoction, and mixing;
(2) concentrating the decocted liquid obtained in the step (1) to obtain an extract, and concentrating until the relative density is 1.14 at 65 ℃;
(3) spray drying and granulating the extract obtained in the step (2), wherein the air inlet temperature is 92 ℃, the material temperature is 64 ℃, and the air volume is 0.78m during spray drying3Min, the feeding amount of the extract is 0.4 kg/min.
In comparison to example 3, comparative example 1 had no sweet clover.
Comparative example 2: a traditional Chinese medicine granule for treating viral hepatitis comprises the following raw materials in parts by weight: 12 parts of scutellaria baicalensis, 12 parts of yellow sweet clover, 10 parts of cape jasmine, 8 parts of desmodium, 12 parts of oldenlandia diffusa, 6 parts of lophatherum gracile and 3 parts of liquorice.
The preparation method of the traditional Chinese medicine granule for treating viral hepatitis comprises the following steps:
(1) adding ethanol into Melilotus officinalis, reflux-extracting at 92 deg.C for 2.5h, recovering ethanol, and filtering to obtain filtrate; the solid-to-liquid ratio of meliloti to ethanol is 1g: 35ml of the solution; the volume concentration of the ethanol is 80 percent;
(2) mixing Scutellariae radix, fructus Gardeniae, herba Lysimachiae Christinae, herba Hedyotidis Diffusae, folium Bambusae and Glycyrrhrizae radix at a certain proportion, soaking in water for 1h, wherein the solid-to-liquid ratio of solid raw materials to water is 1g:11 ml; then heating and decocting for 3 times, each time for 20min, filtering, separating, collecting each decoction, and mixing;
(3) mixing the filtrate obtained in the step (1) and the decoction obtained in the step (2) to obtain a mixed solution, concentrating the mixed solution to obtain an extract, and concentrating the extract until the relative density is 1.14 at 65 ℃;
(4) spray drying and granulating the extract obtained in the step (3), wherein the temperature of an air inlet is 92 ℃, the temperature of the material is 64 ℃, and the air volume is 0.78m during spray drying3Min, the feeding amount of the extract is 0.4 kg/min.
Comparative example 2 herba Artemisiae Scopariae compared to example 3.
Comparative example 3: a traditional Chinese medicine granule for treating viral hepatitis comprises the following raw materials in parts by weight: 16 parts of oriental wormwood, 12 parts of scutellaria baicalensis, 12 parts of sweet clover, 10 parts of cape jasmine, 6 parts of lophatherum gracile and 3 parts of liquorice.
The preparation method of the traditional Chinese medicine granule for treating viral hepatitis comprises the following steps:
(1) adding ethanol into Melilotus officinalis, reflux-extracting at 92 deg.C for 2.5h, recovering ethanol, and filtering to obtain filtrate; the solid-to-liquid ratio of meliloti to ethanol is 1g: 35ml of the solution; the volume concentration of the ethanol is 80 percent;
(2) mixing herba Artemisiae Scopariae, Scutellariae radix, fructus Gardeniae, folium Bambusae and Glycyrrhrizae radix at a certain proportion, soaking in water for 1h, wherein the solid-to-liquid ratio of the solid material to water is 1g:11 ml; then heating and decocting for 3 times, each time for 20min, filtering, separating, collecting each decoction, and mixing;
(3) mixing the filtrate obtained in the step (1) and the decoction obtained in the step (2) to obtain a mixed solution, concentrating the mixed solution to obtain an extract, and concentrating the extract until the relative density is 1.14 at 65 ℃;
(4) spray drying and granulating the extract obtained in the step (3), wherein the temperature of an air inlet is 92 ℃, the temperature of the material is 64 ℃, and the air volume is 0.78m during spray drying3Min, the feeding amount of the extract is 0.4 kg/min.
Comparative example 3 had no lysimachia christinae and oldenlandia diffusa as compared to example 3.
Comparative experiment
Subject: female cleaning grade C3H mice (supplied by the central laboratory animal, Shandong province) 6-8 weeks, weighing 21 + -2 g, were acclimatized and the test was started two weeks after acclimatization.
The experimental method comprises the following steps: 6 mice were injected with normal saline as a blank control.
50 mice of C3H were subjected to MHV-3 infection model establishment, purified MHV-3 virus was diluted and C3H mice were intraperitoneally injected at 10PFU/200uL each, and some mice between 5d and 12d died after MHV-3 infection of C3H mice, 8 were died, and the remaining 42 MHV-3 infected mouse models.
The remaining 42 MHV-3 infected mouse models were divided on average into 7 groups of 6, each of which was a model control group, example 1 group, example 2 group, example 3 group, comparative example 1 group, comparative example 2 group, and comparative example 3 group, respectively.
Example 1 the group of Chinese medicinal granules prepared in example 1 were fed daily for 10 consecutive days, 0.3 g;
example 2 groups were fed with 0.3g of the Chinese medicinal granules prepared in example 2 daily for 10 consecutive days;
example 3 groups were fed with 0.3g of the Chinese medicinal granules prepared in example 3 daily for 10 consecutive days;
the group of the comparative example 1 is fed with 0.3g of the traditional Chinese medicine granules prepared in the group of the comparative example 1 every day for 10 consecutive days;
the group of the comparative example 2 is fed with 0.3g of the traditional Chinese medicine granules prepared in the group of the comparative example 2 every day for 10 consecutive days;
comparative example 3 group was fed 0.3g of the Chinese medicinal granules prepared in comparative example 3 daily for 10 consecutive days;
the model control group and the blank group were each fed with physiological saline for 10 consecutive days.
After 10 days, anesthetizing the mice with ether, picking eyeballs to collect peripheral blood, centrifuging, collecting serum, and carrying out serum biochemical index detection, wherein the experimental results are shown in the following table:
group of | Glutamic-pyruvic transaminase (ALT) | Glutamic-oxalacetic transaminase (AST) | Total Protein (TP) | Albumin (ALB) |
Blank group | 23.85±2.33 | 53.12±2.69 | 52.31±1.62 | 34.21±1.05 |
Model control group | 501.33±53.32 | 852.31±213.1 | 43.13±3.14 | 26.14±3.16 |
EXAMPLE 1 group | 42.56±4.67 | 78.12±3.53 | 49.31±1.51 | 30.03±0.75 |
EXAMPLE 2 group | 41.89±5.18 | 76.61±2.88 | 48.36±1.23 | 31.49±0.67 |
EXAMPLE 3 group | 36.67±2.13 | 68.15±2.11 | 51.68±1.87 | 33.08±0.95 |
Comparative example 1 group | 97.59±12.33 | 101.12±20.75 | 45.66±2.15 | 28.42±1.82 |
Comparative example 2 group | 98.78±10.25 | 108.85±25.16 | 44.16±2.03 | 27.15±1.36 |
Comparative example 3 group | 102.31±14.56 | 126.82±29.71 | 44.01±2.35 | 26.75±1.58 |
As can be seen from the above table, the groups of example 1, example 2 and example 3 of the present invention can significantly inhibit the increase of glutamic-pyruvic transaminase and glutamic-oxalacetic transaminase, can significantly inhibit the decrease of total protein and albumin, and have significant efficacy on viral hepatitis, especially the best effect of example 3, compared with the groups of comparative example 1, comparative example 2 and comparative example 3.
The above description is only a preferred embodiment of the present application and is not intended to limit the present application, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, improvement and the like made within the spirit and principle of the present application shall be included in the protection scope of the present application.
Claims (10)
1. The traditional Chinese medicine granule for treating viral hepatitis is characterized by comprising the following raw materials in parts by weight: 16-26 parts of oriental wormwood, 12-26 parts of scutellaria baicalensis, 12-20 parts of yellow sweet clover, 10-20 parts of cape jasmine, 8-16 parts of desmodium, 12-16 parts of oldenlandia diffusa, 6-18 parts of lophatherum gracile and 3-9 parts of liquorice.
2. The traditional Chinese medicine granule for treating viral hepatitis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 18-23 parts of oriental wormwood, 14-22 parts of scutellaria baicalensis, 14-18 parts of yellow sweet clover, 12-18 parts of cape jasmine, 10-14 parts of desmodium, 13-15 parts of oldenlandia diffusa, 8-16 parts of lophatherum gracile and 4-8 parts of liquorice.
3. The traditional Chinese medicine granule for treating viral hepatitis according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 19-21 parts of oriental wormwood, 16-20 parts of scutellaria baicalensis, 15-16 parts of sweet clover, 14-16 parts of cape jasmine, 11-13 parts of lysimachia christinae hance, 14-15 parts of oldenlandia diffusa, 10-12 parts of lophatherum gracile and 5-7 parts of liquorice.
4. The preparation method of the traditional Chinese medicine granule for treating viral hepatitis according to any one of claims 1 to 3, characterized by comprising the following steps:
(1) adding ethanol into Melilotus officinalis, reflux-extracting at 90-95 deg.C for 2-3 hr, recovering ethanol, and filtering to obtain filtrate;
(2) mixing herba Artemisiae Scopariae, Scutellariae radix, fructus Gardeniae, herba Lysimachiae Christinae, herba Hedyotidis Diffusae, folium Bambusae and Glycyrrhrizae radix at a certain proportion, soaking in water, heating and decocting for 2-3 times, filtering, separating, collecting decoctions, and mixing;
(3) mixing the filtrate obtained in the step (1) and the decoction obtained in the step (2) to obtain a mixed solution, and concentrating the mixed solution to obtain an extract;
(4) and (4) carrying out spray drying and granulation on the extract obtained in the step (3).
5. The preparation method of the traditional Chinese medicine granule for treating viral hepatitis according to claim 4, which is characterized by comprising the following steps: in the step (1), the solid-to-liquid ratio of meliloti to ethanol is 1g: (30-40) ml.
6. The preparation method of the traditional Chinese medicine granule for treating viral hepatitis according to claim 4, which is characterized by comprising the following steps: in the step (1), the volume concentration of the ethanol is 70-80%.
7. The preparation method of the traditional Chinese medicine granule for treating viral hepatitis according to claim 4, which is characterized by comprising the following steps: in the step (2), when the mixture is soaked in water, the solid-to-liquid ratio of the solid raw material to the water is 1g (10-12) ml.
8. The preparation method of the traditional Chinese medicine granule for treating viral hepatitis according to claim 4, which is characterized by comprising the following steps: in the step (2), the time for each decoction is 20-30 min.
9. The preparation method of the traditional Chinese medicine granule for treating viral hepatitis according to claim 4, which is characterized by comprising the following steps: in the step (3), the extract is concentrated to the relative density of 1.12-1.16 at 65 ℃ when being concentrated.
10. The preparation method of the traditional Chinese medicine granule for treating viral hepatitis according to claim 4, which is characterized by comprising the following steps: in the step (4), during spray drying, the temperature of an air inlet is 90-95 ℃, the temperature of the material is 62-65 ℃, and the air volume is 0.7-0.8m3Min, the feeding amount of the extract is 0.3-0.4 kg/min.
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