CN112020560A - 一种RNA编辑的CRISPR/Cas效应蛋白及系统 - Google Patents
一种RNA编辑的CRISPR/Cas效应蛋白及系统 Download PDFInfo
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Abstract
本发明涉及核酸编辑领域，特别是规律成簇的间隔短回文重复(CRISPR)技术领域。具体而言，本发明涉及Cas效应蛋白，包含此类蛋白的融合蛋白，以及编码它们的核酸分子。本发明还涉及用于核酸编辑(例如，基因或基因组编辑)的复合物和组合物，其包含本发明的蛋白或融合蛋白，或编码它们的核酸分子。本发明还涉及用于核酸编辑(例如，基因或基因组编辑)的方法，其使用包含本发明的蛋白或融合蛋白。
Description
PCT国内申请，说明书已公开。
Claims (69)
- PCT国内申请，权利要求书已公开。
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| CN2018103774680 | 2018-04-25 | ||
| PCT/CN2019/084340 WO2019206233A1 (zh) | 2018-04-25 | 2019-04-25 | 一种RNA编辑的CRISPR/Cas效应蛋白及系统 |
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| CN113462672A (zh) * | 2018-11-15 | 2021-10-01 | 中国农业大学 | CRISPR-Cas12j酶和系统 |
| CN116590257B (zh) * | 2020-02-28 | 2024-04-30 | 辉大(上海)生物科技有限公司 | VI-E型和VI-F型CRISPR-Cas系统及其用途 |
| WO2022098681A2 (en) * | 2020-11-03 | 2022-05-12 | Caspr Biotech Corporation | Novel class 2 crispr-cas rna-guided endonucleases |
| WO2023029532A1 (en) * | 2021-08-30 | 2023-03-09 | Huigene Therapeutics Co., Ltd. | Engineered cas6 protein and uses thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016507244A (ja) * | 2013-02-27 | 2016-03-10 | ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト（ゲーエムベーハー）Ｈｅｌｍｈｏｌｔｚ Ｚｅｎｔｒｕｍ ＭｕｅｎｃｈｅｎＤｅｕｔｓｃｈｅｓ Ｆｏｒｓｃｈｕｎｇｓｚｅｎｔｒｕｍ ｆｕｅｒ Ｇｅｓｕｎｄｈｅｉｔ ｕｎｄ Ｕｍｗｅｌｔ （ＧｍｂＨ） | Ｃａｓ９ヌクレアーゼによる卵母細胞における遺伝子編集 |
| US20170145405A1 (en) * | 2015-11-25 | 2017-05-25 | The Board Of Trustees Of The Leland Stanford Junior University | Crispr/cas-mediated genome editing to treat egfr-mutant lung cancer |
| DE202013012597U1 (de) * | 2012-10-23 | 2017-11-21 | Toolgen, Inc. | Zusammensetzung zum Spalten einer Ziel-DNA, umfassend eine für die Ziel-DNA spezifische guide-RNA und eine Cas-Protein-codierende Nukleinsäure oder ein Cas-Protein, sowie deren Verwendung |
| US20180100148A1 (en) * | 2016-10-07 | 2018-04-12 | Integrated Dna Technologies, Inc. | S. pyogenes cas9 mutant genes and polypeptides encoded by same |
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- 2019-04-25 WO PCT/CN2019/084340 patent/WO2019206233A1/zh active Application Filing
- 2019-04-25 CN CN201980028197.0A patent/CN112020560B/zh active Active
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| DE202013012597U1 (de) * | 2012-10-23 | 2017-11-21 | Toolgen, Inc. | Zusammensetzung zum Spalten einer Ziel-DNA, umfassend eine für die Ziel-DNA spezifische guide-RNA und eine Cas-Protein-codierende Nukleinsäure oder ein Cas-Protein, sowie deren Verwendung |
| JP2016507244A (ja) * | 2013-02-27 | 2016-03-10 | ヘルムホルツ・ツェントルム・ミュンヒェン・ドイチェス・フォルシュンクスツェントルム・フューア・ゲズントハイト・ウント・ウムベルト（ゲーエムベーハー）Ｈｅｌｍｈｏｌｔｚ Ｚｅｎｔｒｕｍ ＭｕｅｎｃｈｅｎＤｅｕｔｓｃｈｅｓ Ｆｏｒｓｃｈｕｎｇｓｚｅｎｔｒｕｍ ｆｕｅｒ Ｇｅｓｕｎｄｈｅｉｔ ｕｎｄ Ｕｍｗｅｌｔ （ＧｍｂＨ） | Ｃａｓ９ヌクレアーゼによる卵母細胞における遺伝子編集 |
| US20170145405A1 (en) * | 2015-11-25 | 2017-05-25 | The Board Of Trustees Of The Leland Stanford Junior University | Crispr/cas-mediated genome editing to treat egfr-mutant lung cancer |
| US20180100148A1 (en) * | 2016-10-07 | 2018-04-12 | Integrated Dna Technologies, Inc. | S. pyogenes cas9 mutant genes and polypeptides encoded by same |
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