CN112014571A - C-反应蛋白胶体金法半定量检测装置 - Google Patents
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Abstract
本发明提供了一种C‑反应蛋白胶体金法半定量检测装置。该技术方案利用轴承设置了转盘,在转盘外周固定齿圈,利用内置的部件电机驱动齿轮转动,齿轮与齿圈相啮合,从而驱动转盘执行步进旋转运动;在转盘上,通过基板和槽架构建了槽体结构,在槽体结构中容纳反应管,反应管在上述步进运动的作用下逐一经过加样器和加药器下方,从而自动化的实现待测样品与胶体金试剂的混合。基于以上技术原理,使本发明可批量化、自动化的完成加样及反应过程,无需人为辅助,具有更高的检测效率。本发明以创新性的技术改进实现了良好的技术效果,其成本较低、易于实现,具有突出的技术优势。
Description
技术领域
本发明涉及医学检测技术领域,具体涉及一种C-反应蛋白胶体金法半定量检测装置。
背景技术
C反应蛋白(C-reactive protein,CRP)是指在机体受到感染或组织损伤时血浆中一些急剧上升的蛋白质(急性蛋白)。CRP可以激活补体和加强吞噬细胞的吞噬而起调理作用,从而清除入侵机体的病原微生物和损伤、坏死、凋亡的组织细胞,在机体的天然免疫过程中发挥重要的保护作用。
CRP不仅是一种非特异的炎症标志物,其本身直接参与了炎症与动脉粥样硬化等心血管疾病,并且是心血管疾病最强有力的预示因子与危险因子。CRP与补体Clq及FcTR的相互作用使其表现出很多生物活性,包括宿主对感染的防御反应、对炎症反应的吞噬作用和调节作用等。与受损细胞、凋亡细胞及核抗原的结合,使其在自身免疫病方面也起着重要作用
CRP测定具有重要的临床意义。
(1)各种急性炎症、组织损伤、心肌梗死、手术创伤、放射性损伤等疾病发作后数小时迅速升高,并有成倍增长之势。病变好转时,又迅速降至正常,其升高幅度与感染的程度呈正相关。手术后患者CRP升高,术后7~10天CRP水平应下降,如CRP不降低或再次升高,提示可能并发感染或血栓栓塞。
(2)CRP与其他炎症因子,如白细胞总数、红细胞沉降率和多形核白细胞等具有密切相关性。又与WBC存在正相关。在炎症反应中起着积极作用,使人体具有非特异性抵抗力。在患者疾病发作时,可早于WBC而上升,恢复正常也很快,故具有极高的敏感性。
(3)帮助辨别呼吸道感染类型。CRP可用于细菌和病毒感染的鉴别诊断:细菌感染时,CRP水平升高;而病毒感染时,CRP不升高或轻度升高,因此CRP值可以帮助医生辨别呼吸道感染的类型,有针对性的给予药物和治疗。
(4)恶性肿瘤患者CRP都升高,如CRP与AFP的联合检测,可用于肝癌与肝脏良性疾病的鉴别诊断,应用于肝癌疗效及预后的判断。手术前CRP上升,手术后则下降,且其反应不受放疗、化疗和皮质激素治疗的影响,有助于评估肿瘤的进程。
(5)评估急性胰腺炎的严重程度,当CRP高于250mg/L时,则提示为广泛坏死性胰腺炎。
(6)用超敏乳胶增强法测CRP,能提高测定的敏感性,可用于冠心病和心梗危险性的预测。
C-反应蛋白分析仪是采用免疫散射比浊法或胶体金法对C反应蛋白在血液中的浓度进行检测的免疫分析仪器。目前,基于胶体金法的半定量分析仪,普遍需要手动加样,不仅自动化程度较低,而且操作繁琐、检测效率低下。
发明内容
本发明旨在针对现有技术的技术缺陷,提供一种C-反应蛋白胶体金法半定量检测装置,以解决现有技术中,常规C-反应蛋白分析仪无法自动加样的技术问题。
为实现以上技术目的,本发明采用以下技术方案:
C-反应蛋白胶体金法半定量检测装置,包括主机,转盘,齿圈,反应管,加药器,加样器,凸出轴,安装口,基板,槽架,连接杆,槽体,其中,在主机上连接有轴承,在所述轴承上连接有转盘,在转盘的边缘处固定连接有齿圈,在主机中内置有步进电机,所述步进电机通过齿轮与齿圈传动连接;在转盘上具有凸出轴,在基板上开设有安装口,基板通过安装口插接固定在凸出轴上,在基板的上端通过连接杆固定连接有槽架,槽架与基板相互平行,在槽架上开设有若干槽体,在槽体中插接有反应管,在主机上分别设置有加药器和加样器。
作为优选,还包括扣盖,所扣盖铰接在主机上,所述扣盖笼罩在槽架的上方。
作为优选,还包括地脚,所述地脚设置于主机底端,所述地脚的数量为4个,所述地脚为可调节地脚。
作为优选,加药器设置有旋转臂,所述旋转臂的转轴竖直,在所述旋转臂的末端设置有升降机构,在所述升降机构下端设置有管体,在所述管体的根部具有一容腔,在所述容腔上端连接有液泵。
作为优选,加样器设置有旋转臂,所述旋转臂的转轴竖直,在所述旋转臂的末端设置有升降机构,在所述升降机构下端设置有管体,在所述管体的根部具有一容腔,在所述容腔上端连接有液泵。
作为优选,还包括照明灯和紫外灯,照明灯和紫外灯分别设置于主机的内壁上。
作为优选,还包括引风机,所述引风机的引风口位于基板侧方。
本发明提供了一种C-反应蛋白胶体金法半定量检测装置。该技术方案利用轴承设置了转盘,在转盘外周固定齿圈,利用内置的部件电机驱动齿轮转动,齿轮与齿圈相啮合,从而驱动转盘执行步进旋转运动;在转盘上,通过基板和槽架构建了槽体结构,在槽体结构中容纳反应管,反应管在上述步进运动的作用下逐一经过加样器和加药器下方,从而自动化的实现待测样品与胶体金试剂的混合。基于以上技术原理,使本发明可批量化、自动化的完成加样及反应过程,无需人为辅助,具有更高的检测效率。本发明以创新性的技术改进实现了良好的技术效果,其成本较低、易于实现,具有突出的技术优势。
附图说明
图1是本发明整体的结构图;
图2是当卸除基板、槽架等组件后,本发明的结构图;
图3是本发明中,基板、槽架等组件的结构图;
图4是本发明中,转盘及齿圈的结构图;
图中
1、主机 2、转盘 3、齿圈 4、反应管
5、加药器 6、加样器 7、凸出轴 8、安装口
9、基板 10、槽架 11、连接杆 12、槽体。
具体实施方式
以下将对本发明的具体实施方式进行详细描述。为了避免过多不必要的细节,在以下实施例中对属于公知的结构或功能将不进行详细描述。以下实施例中所使用的近似性语言可用于定量表述,表明在不改变基本功能的情况下可允许数量有一定的变动。除有定义外,以下实施例中所用的技术和科学术语具有与本发明所属领域技术人员普遍理解的相同含义。
实施例1
C-反应蛋白胶体金法半定量检测装置,如图1~4所示,包括主机1,转盘2,齿圈3,反应管4,加药器5,加样器6,凸出轴7,安装口8,基板9,槽架10,连接杆11,槽体12,其中,在主机1上连接有轴承,在所述轴承上连接有转盘2,在转盘2的边缘处固定连接有齿圈3,在主机1中内置有步进电机,所述步进电机通过齿轮与齿圈3传动连接;在转盘2上具有凸出轴7,在基板9上开设有安装口8,基板9通过安装口8插接固定在凸出轴7上,在基板9的上端通过连接杆11固定连接有槽架10,槽架10与基板9相互平行,在槽架10上开设有若干槽体12,在槽体12中插接有反应管4,在主机1上分别设置有加药器5和加样器6。
实施例2
C-反应蛋白胶体金法半定量检测装置,如图1~4所示,包括主机1,转盘2,齿圈3,反应管4,加药器5,加样器6,凸出轴7,安装口8,基板9,槽架10,连接杆11,槽体12,其中,在主机1上连接有轴承,在所述轴承上连接有转盘2,在转盘2的边缘处固定连接有齿圈3,在主机1中内置有步进电机,所述步进电机通过齿轮与齿圈3传动连接;在转盘2上具有凸出轴7,在基板9上开设有安装口8,基板9通过安装口8插接固定在凸出轴7上,在基板9的上端通过连接杆11固定连接有槽架10,槽架10与基板9相互平行,在槽架10上开设有若干槽体12,在槽体12中插接有反应管4,在主机1上分别设置有加药器5和加样器6。
同时,还包括扣盖,所扣盖铰接在主机1上,所述扣盖笼罩在槽架10的上方。还包括地脚,所述地脚设置于主机1底端,所述地脚的数量为4个,所述地脚为可调节地脚。加药器5设置有旋转臂,所述旋转臂的转轴竖直,在所述旋转臂的末端设置有升降机构,在所述升降机构下端设置有管体,在所述管体的根部具有一容腔,在所述容腔上端连接有液泵。加样器6设置有旋转臂,所述旋转臂的转轴竖直,在所述旋转臂的末端设置有升降机构,在所述升降机构下端设置有管体,在所述管体的根部具有一容腔,在所述容腔上端连接有液泵。还包括照明灯和紫外灯,照明灯和紫外灯分别设置于主机1的内壁上。还包括引风机,所述引风机的引风口位于基板9侧方。
以上对本发明的实施例进行了详细说明,但所述内容仅为本发明的较佳实施例,并不用以限制本发明。凡在本发明的申请范围内所做的任何修改、等同替换和改进等,均应包含在本发明的保护范围之内。
Claims (7)
1.C-反应蛋白胶体金法半定量检测装置,其特征在于包括主机(1),转盘(2),齿圈(3),反应管(4),加药器(5),加样器(6),凸出轴(7),安装口(8),基板(9),槽架(10),连接杆(11),槽体(12),其中,在主机(1)上连接有轴承,在所述轴承上连接有转盘(2),在转盘(2)的边缘处固定连接有齿圈(3),在主机(1)中内置有步进电机,所述步进电机通过齿轮与齿圈(3)传动连接;在转盘(2)上具有凸出轴(7),在基板(9)上开设有安装口(8),基板(9)通过安装口(8)插接固定在凸出轴(7)上,在基板(9)的上端通过连接杆(11)固定连接有槽架(10),槽架(10)与基板(9)相互平行,在槽架(10)上开设有若干槽体(12),在槽体(12)中插接有反应管(4),在主机(1)上分别设置有加药器(5)和加样器(6)。
2.根据权利要求1所述的C-反应蛋白胶体金法半定量检测装置,其特征在于还包括扣盖,所扣盖铰接在主机(1)上,所述扣盖笼罩在槽架(10)的上方。
3.根据权利要求1所述的C-反应蛋白胶体金法半定量检测装置,其特征在于还包括地脚,所述地脚设置于主机(1)底端,所述地脚的数量为4个,所述地脚为可调节地脚。
4.根据权利要求1所述的C-反应蛋白胶体金法半定量检测装置,其特征在于加药器(5)设置有旋转臂,所述旋转臂的转轴竖直,在所述旋转臂的末端设置有升降机构,在所述升降机构下端设置有管体,在所述管体的根部具有一容腔,在所述容腔上端连接有液泵。
5.根据权利要求1所述的C-反应蛋白胶体金法半定量检测装置,其特征在于加样器(6)设置有旋转臂,所述旋转臂的转轴竖直,在所述旋转臂的末端设置有升降机构,在所述升降机构下端设置有管体,在所述管体的根部具有一容腔,在所述容腔上端连接有液泵。
6.根据权利要求1所述的C-反应蛋白胶体金法半定量检测装置,其特征在于还包括照明灯和紫外灯,照明灯和紫外灯分别设置于主机(1)的内壁上。
7.根据权利要求1所述的C-反应蛋白胶体金法半定量检测装置,其特征在于还包括引风机,所述引风机的引风口位于基板(9)侧方。
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