CN112007068A - Fermentation method of traditional Chinese medicine eucommia bark - Google Patents
Fermentation method of traditional Chinese medicine eucommia bark Download PDFInfo
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- CN112007068A CN112007068A CN202010974677.0A CN202010974677A CN112007068A CN 112007068 A CN112007068 A CN 112007068A CN 202010974677 A CN202010974677 A CN 202010974677A CN 112007068 A CN112007068 A CN 112007068A
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- cortex eucommiae
- bark
- eucommia bark
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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Abstract
The invention discloses a fermentation method of traditional Chinese medicine eucommia bark, which relates to the technical field of traditional Chinese medicine processing and comprises the following steps: removing coarse bark from cortex Eucommiae, cleaning, steaming with steam, and air drying; spraying draught beer on cortex Eucommiae, stacking and fermenting until the inner skin is purple brown, and drying; spraying draught beer on cortex Eucommiae again, stacking, fermenting, and drying; cutting cortex Eucommiae into cubes or strips, and parching to slight fragrance. The method is characterized in that firstly, eucommia bark is steamed and pretreated, so that the retention of functional components is facilitated, then draught beer is used as a strain source, the draught beer is sprayed on the surface of the eucommia bark and is stacked for fermentation, the bark is completely fermented through the chemical reaction of microorganisms, and cellulose, hemicellulose and lignin in the eucommia bark are partially degraded, so that eucommia bark colloid is exposed outside, the dissolution of the functional components in the eucommia bark is facilitated, and then, the eucommia bark is fried to be slightly fragrant.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine processing, in particular to a fermentation method of traditional Chinese medicine eucommia bark.
Background
Eucommia ulmoides, also known as Bakelite, is a plant of the family Eucommiaceae. The bark of eucommia is grayish brown and rough, contains rubber, and is broken and pulled to be provided with a plurality of filaments. The tender branches have yellow brown hair, the alopecia becomes clean after a while, and the old branches have obvious skin pores.
The medicinal eucommia bark, namely the dry bark of eucommia bark, has sweet and warm nature and taste, enters liver and kidney channels, and has the effects of nourishing liver and kidney, strengthening bones and muscles, preventing miscarriage and reducing blood pressure. Since the bark of eucommia contains rubber, the active ingredients of the bark of eucommia are difficult to dissolve out due to the action of rubber threads in the bark of raw eucommia, and thus, the bark of eucommia needs to be processed.
Modern scientific researches prove that the eucommia bark contains various active ingredients such as lignans, iridoids, phenylpropanoids, polysaccharides and the like, wherein pinoresinol diglucoside belongs to lignans compounds, has a remarkable blood pressure reducing effect, is one of main active ingredients in eucommia bark, is mostly used as a qualitative and quantitative standard ingredient of eucommia bark medicinal materials, and in addition, the extract content can also be used as an index for detecting whether the eucommia bark gelatin silk is damaged; at present, the eucommia bark medicinal material is clinically accepted in China and the adopted processing method is a salt water moxibustion method, and the processing method of the salt eucommia bark specified in pharmacopoeia of the people's republic of China 2010 is to take eucommia bark blocks or shreds, but the medicinal effect of the eucommia bark prepared by the method cannot reach the best state, and the medicinal effect cannot be fully exerted.
Disclosure of Invention
Based on the technical problems in the background art, the invention provides a fermentation method of traditional Chinese medicine eucommia bark, which takes draught beer as a strain source to carry out fermentation treatment on the eucommia bark, and the eucommia bark processed by the method has the advantages of easy release of functional components, improved drug effect and reduced side effect.
The invention provides a fermentation method of traditional Chinese medicine eucommia bark, which comprises the following steps:
s1, steaming: removing coarse bark from cortex Eucommiae, cleaning, steaming with steam, and air drying;
s2, primary fermentation: spraying draught beer on the steamed cortex Eucommiae, stacking and fermenting until the inner skin is purple brown, and drying;
s3, secondary fermentation: spraying draught beer on the cortex Eucommiae after primary fermentation, stacking, fermenting, and drying;
s4, baking: cutting the cortex Eucommiae after secondary fermentation into square or thread, and parching to slight fragrance.
Preferably, in S1, steaming in boiling water for 1-5 min.
Preferably, in S2, the spray amount of draught beer is 30-40% of the initial weight of the eucommia ulmoides bark.
Preferably, in S2, the fermented product is stacked for 7-10 days and dried to water content of 20-25%.
Preferably, in S3, the spray amount of draught beer is 20-30% of the initial weight of cortex eucommiae.
Preferably, in S3, stacking and fermenting for 10-14d, and drying until the water content is 6-10%.
Preferably, in S4, the roasting temperature is 140-180 ℃, and the roasting time is 4-7 min.
The invention also provides the traditional Chinese medicine eucommia bark prepared by the fermentation method.
Has the advantages that: the invention provides a fermentation method of eucommia bark, which is obtained by firstly steaming raw eucommia bark, then adding draught beer, fermenting twice and then frying. Firstly, steam steaming pretreatment is adopted to avoid the decomposition of bioactive substances in the eucommia bark by enzyme, which is beneficial to the maintenance of functional components, the draught beer is rich in nutrition, contains components such as saccharides, amino acid, trace elements and the like, and also contains live yeast and vitamin B group, the draught beer is taken as a strain source and sprayed on the surface of the eucommia bark to be stacked and fermented, through the chemical reaction of microorganisms, the bark is completely fermented through two times of stacking fermentation, the fermented eucommia bark has visible hypha, and cellulose, hemicellulose and lignin in the eucommia bark are partially degraded, so that the eucommia colloid is exposed outside, the dissolution of the functional components in the eucommia bark is facilitated, and the eucommia bark is fried to have slight fragrance, so that the functional components in the eucommia bark processed by the method are easy to release, the drug effect is improved, the side effect is reduced, and the dissolution rate of the pinoresinol diglucoside after fermentation processing can be improved by 82.4 percent compared with a raw eucommia bark product.
Detailed Description
The technical solution of the present invention will be described in detail below with reference to specific examples.
Example 1
The invention provides a fermentation method of traditional Chinese medicine eucommia bark, which comprises the following steps:
s1, steaming: removing coarse bark from cortex Eucommiae, cleaning, steaming in boiling water for 1min, and air drying;
s2, primary fermentation: spraying draught beer on the steamed eucommia bark, wherein the spraying amount is 30% of the initial weight of the eucommia bark, piling and fermenting for 7 days until the inner skin is purple brown, and drying until the water content is 20%;
s3, secondary fermentation: spraying draught beer on the eucommia bark after primary fermentation, wherein the spraying amount is 20% of the initial weight of the eucommia bark, piling up and fermenting for 10 days, and drying until the water content is 6%;
s4, baking: cutting the cortex Eucommiae after secondary fermentation into square or thread, baking at 140 deg.C for 4min to slight fragrance.
Example 2
The invention provides a fermentation method of traditional Chinese medicine eucommia bark, which comprises the following steps:
s1, steaming: removing coarse bark from cortex Eucommiae, cleaning, steaming in boiling water for 5min, and air drying;
s2, primary fermentation: spraying draught beer on the steamed eucommia bark, wherein the spraying amount is 40% of the initial weight of the eucommia bark, stacking and fermenting for 10 days until the inner skin is purple brown, and drying until the water content is 25%;
s3, secondary fermentation: spraying draught beer on the eucommia bark after primary fermentation, wherein the spraying amount is 30% of the initial weight of the eucommia bark, stacking and fermenting for 14d, and drying until the water content is 10%;
s4, baking: cutting the cortex Eucommiae after secondary fermentation into square or thread, baking at 180 deg.C for 7min to slight fragrance.
Example 3
The invention provides a fermentation method of traditional Chinese medicine eucommia bark, which comprises the following steps:
s1, steaming: removing coarse bark from cortex Eucommiae, cleaning, steaming in boiling water for 2min, and air drying;
s2, primary fermentation: spraying draught beer on steamed cortex Eucommiae, wherein the spraying amount is 35% of the initial weight of cortex Eucommiae, stacking and fermenting for 8 days until the endothelium is purple brown, and drying to water content of 24%;
s3, secondary fermentation: spraying draught beer on the eucommia bark after primary fermentation, wherein the spraying amount is 25% of the initial weight of the eucommia bark, piling up for fermentation for 12d, and drying until the water content is 7%;
s4, baking: cutting the cortex Eucommiae after secondary fermentation into square or thread, baking at 150 deg.C for 5min to slight fragrance.
Example 4
The invention provides a fermentation method of traditional Chinese medicine eucommia bark, which comprises the following steps:
s1, steaming: removing coarse bark from cortex Eucommiae, cleaning, steaming in boiling water for 4min, and air drying;
s2, primary fermentation: spraying draught beer on the steamed eucommia bark, wherein the spraying amount is 37% of the initial weight of the eucommia bark, piling and fermenting for 9 days until the inner skin is purple brown, and drying until the water content is 23%;
s3, secondary fermentation: spraying draught beer on the eucommia bark which is subjected to primary fermentation, wherein the spraying amount is 28% of the initial weight of the eucommia bark, stacking and fermenting for 13d, and drying until the water content is 8%;
s4, baking: cutting the cortex Eucommiae after secondary fermentation into square or thread, baking at 160 deg.C for 6min to slight fragrance.
The composition of the bark of eucommia ulmoides prepared in examples 1 to 4 of the present invention was examined.
The test method comprises the following steps: equally dividing cortex eucommiae into 5 groups, wherein 5 groups have no significant difference, taking 1 group of crude cortex eucommiae as a blank group, and performing fermentation processing on the other 4 groups according to the methods in the embodiments 1-4 respectively, and detecting the content of cellulose, hemicellulose and lignin in each group of cortex eucommiae; and (3) putting 1g of the eucommia bark obtained after each group of fermentation into a beaker, adding 25mL of methanol, carrying out ultrasonic treatment for 1h, filtering, and determining the content of the pinoresinol diglucoside by adopting a chromatography method.
And (3) test results: compared with the blank group of raw eucommia bark products, the content of cellulose, hemicellulose and lignin in the eucommia bark in the embodiments 1-4 is obviously reduced, wherein compared with the blank group, the content of the cellulose, the content of the hemicellulose and the content of the lignin in the eucommia bark in the embodiment 4 are respectively reduced by 50.24%, 30.17% and 13.81%; the content of pinoresinol diglucoside in the raw eucommia bark products in the blank group is 0.142%, and the content of pinoresinol diglucoside in processed eucommia bark products in the embodiment 4 is improved by 82.4% and can reach 0.259%.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (8)
1. A fermentation method of traditional Chinese medicine eucommia bark is characterized by comprising the following steps:
s1, steaming: removing coarse bark from cortex Eucommiae, cleaning, steaming with steam, and air drying;
s2, primary fermentation: spraying draught beer on the steamed cortex Eucommiae, stacking and fermenting until the inner skin is purple brown, and drying;
s3, secondary fermentation: spraying draught beer on the cortex Eucommiae after primary fermentation, stacking, fermenting, and drying;
s4, baking: cutting the cortex Eucommiae after secondary fermentation into square or thread, and parching to slight fragrance.
2. The fermentation method of cortex Eucommiae as claimed in claim 1, wherein in S1, steaming in boiling water for 1-5 min.
3. The fermentation method of cortex Eucommiae as claimed in claim 1 or 2, wherein the amount of draught beer sprayed in S2 is 30-40% of the initial weight of cortex Eucommiae.
4. The fermentation method of cortex Eucommiae as claimed in any one of claims 1-3, wherein in S2, the cortex Eucommiae is stacked and fermented for 7-10 days, and dried to water content of 20-25%.
5. The fermentation method of eucommia ulmoides bark as a Chinese medicine according to any one of claims 1 to 4, wherein the amount of spray of draught beer in S3 is 20-30% of the initial weight of eucommia ulmoides bark.
6. The fermentation method of cortex Eucommiae as claimed in any one of claims 1-5, wherein in S3, the cortex Eucommiae is stacked and fermented for 10-14d, and dried to water content of 6-10%.
7. The fermentation method of eucommia ulmoides bark as claimed in any one of claims 1 to 6, wherein the baking temperature is 140-180 ℃ and the baking time is 4-7min in S4.
8. A Chinese medicinal eucommia bark, which is prepared by the fermentation method according to any one of claims 1 to 7.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010974677.0A CN112007068A (en) | 2020-09-16 | 2020-09-16 | Fermentation method of traditional Chinese medicine eucommia bark |
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| CN202010974677.0A CN112007068A (en) | 2020-09-16 | 2020-09-16 | Fermentation method of traditional Chinese medicine eucommia bark |
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| CN112007068A true CN112007068A (en) | 2020-12-01 |
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| CN202010974677.0A Pending CN112007068A (en) | 2020-09-16 | 2020-09-16 | Fermentation method of traditional Chinese medicine eucommia bark |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104142046A (en) * | 2014-08-25 | 2014-11-12 | 济南康众医药科技开发有限公司 | Method for drying eucommia ulmoides |
| CN104147087A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Drying method of eucommia ulmoides |
| CN104288207A (en) * | 2014-10-14 | 2015-01-21 | 南江县百草中药材有限公司 | Method for preparing eucommia ulmoides medicinal slices |
| CN104431137A (en) * | 2014-10-18 | 2015-03-25 | 全椒贡菊园茶厂 | Preparation method of eucommia tea |
-
2020
- 2020-09-16 CN CN202010974677.0A patent/CN112007068A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104142046A (en) * | 2014-08-25 | 2014-11-12 | 济南康众医药科技开发有限公司 | Method for drying eucommia ulmoides |
| CN104147087A (en) * | 2014-08-25 | 2014-11-19 | 济南康众医药科技开发有限公司 | Drying method of eucommia ulmoides |
| CN104288207A (en) * | 2014-10-14 | 2015-01-21 | 南江县百草中药材有限公司 | Method for preparing eucommia ulmoides medicinal slices |
| CN104431137A (en) * | 2014-10-18 | 2015-03-25 | 全椒贡菊园茶厂 | Preparation method of eucommia tea |
Non-Patent Citations (2)
| Title |
|---|
| 姚荣林 等: "《中药鉴定技术》", 31 January 2017, 中国医药科技出版社 * |
| 龚千锋: "《中药炮制学》", 31 January 2013, 中国中医药出版社 * |
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Application publication date: 20201201 |