CN111999288A - Pathogen and antibody detection system for mobile terminal - Google Patents

Pathogen and antibody detection system for mobile terminal Download PDF

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Publication number
CN111999288A
CN111999288A CN202010901063.XA CN202010901063A CN111999288A CN 111999288 A CN111999288 A CN 111999288A CN 202010901063 A CN202010901063 A CN 202010901063A CN 111999288 A CN111999288 A CN 111999288A
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operator
identity
module
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余伟华
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Beijing Connection Times Technology Co ltd
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Beijing Connection Times Technology Co ltd
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • G06T7/0014Biomedical image inspection using an image reference approach
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H10/00ICT specially adapted for the handling or processing of patient-related medical or healthcare data
    • G16H10/60ICT specially adapted for the handling or processing of patient-related medical or healthcare data for patient-specific data, e.g. for electronic patient records
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H15/00ICT specially adapted for medical reports, e.g. generation or transmission thereof
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/20ICT specially adapted for the handling or processing of medical images for handling medical images, e.g. DICOM, HL7 or PACS
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H40/00ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices
    • G16H40/60ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices
    • G16H40/67ICT specially adapted for the management or administration of healthcare resources or facilities; ICT specially adapted for the management or operation of medical equipment or devices for the operation of medical equipment or devices for remote operation
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10004Still image; Photographic image
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing

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Abstract

A pathogen and antibody detection system for a mobile terminal ensures authenticity of a device, a reagent or test paper serving as detection equipment from production to detection activity by marking the detection equipment with a unique identification code, ensures authenticity and validity of identities of an operator and a detected person, and improves authenticity and reliability of pathogen and antibody detection.

Description

Pathogen and antibody detection system for mobile terminal
Technical Field
The invention relates to the technical field of medical detection, in particular to a pathogen and antibody detection system for a mobile terminal.
Background
The new coronavirus pneumonia (COVID-19) which is outbreaked at the end of 2019 causes unprecedented crisis and has a permanent trend, the pneumonia is caused by the new coronavirus, the mortality rate is certain, and meanwhile, the virus has strong human-borne capability and can generate a large number of patients in a short term. Important measures for blocking the spread of viruses are early isolation and epidemiological tracking, which requires a digital management system for efficient detection result acquisition, judgment and statistical analysis.
The current medical system is separated from a detection equipment production system, the uniqueness and the authenticity of the detection equipment cannot be ensured, and the authenticity of a detector and the authenticity and the reliability of a detection result cannot be ensured for a detection result facing the public.
Disclosure of Invention
Technical problem to be solved
The pathogen and antibody detection system for the mobile terminal can effectively solve the problems.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: a pathogen and antibody detection system for a mobile terminal comprising:
the identity creating module is used for creating a unique identity for the detection equipment and creating an operator role or a subject role with the unique identity according to the user information;
the binding module is used for binding the detection equipment, the role of the operator and the role of the detected person with the detection activity according to the detection activity to be carried out;
the detection information processing module is used for acquiring the detection result of the detection equipment and judging the accuracy of the detection result;
and the intelligent mobile terminal module is used for identifying the unique identity of the detection equipment, the role of the operator or the role of the person to be detected and acquiring the data of the detection activity for the role of the operator or the role of the person to be detected.
Preferably, the identity creating module generates the identity code corresponding to the operator role or the examinee role according to the registration information, the mobile phone verification code or the LBS information of the user.
Preferably, when the identity creating module creates an operator role or a role of the subject, the identity creating module further generates one or more of a two-dimensional code, an NFC tag, a bluetooth identification address and a WI-FI identification address corresponding to the identity identification code.
Preferably, the operator role binds the detection device or the role of the subject with the detection activity through two-dimensional code scanning, NFC connection, Bluetooth or WI FI connection of the intelligent mobile terminal module to identify the unique identity of the detection device or the role of the subject.
Preferably, the detection information processing module may acquire detection result image information of the detection apparatus by the image pickup apparatus.
Preferably, the detection information processing module compares the detection result image information captured by the image capturing device and the standard output result image information of the detection device according to an image recognition technique to complete the verification of the accuracy of the detection result.
Preferably, the detection information processing module may further summarize detection data of all detection activities and form corresponding map information, and an operator role or a subject role may acquire the map information through the intelligent mobile terminal module.
Preferably, the operator role can also create an organization with a unique identity through the identity creation module.
Preferably, the organization may also create subordinate organizations to which it is affiliated, and other operator characters or subject characters may join the organization or its subordinate organizations.
Preferably, the detection device comprises a colloidal gold test strip.
Advantageous effects
The invention has the beneficial effects that: a pathogen and antibody detection system for a mobile terminal ensures authenticity of a device, a reagent or test paper serving as detection equipment from production to detection activity by marking the detection equipment with a unique identification code, ensures authenticity and validity of identities of an operator and a detected person, and improves authenticity and reliability of pathogen and antibody detection.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides a pathogen and antibody detection system for a mobile terminal, comprising: the identity creating module is used for creating a unique identity for the detection equipment and creating an operator role or a subject role with the unique identity according to the user information;
the binding module is used for binding the detection equipment, the role of the operator and the role of the detected person with the detection activity according to the detection activity to be carried out;
the detection information processing module is used for acquiring the detection result of the detection equipment and judging the accuracy of the detection result;
and the intelligent mobile terminal module is used for identifying the unique identity of the detection equipment, the role of the operator or the role of the person to be detected and acquiring the data of the detection activity for the role of the operator or the role of the person to be detected.
Specifically, the identity creating module generates an identity code corresponding to an operator role or an examinee role according to registration information, a mobile phone verification code or LBS information of a user, and also generates one or more of a two-dimensional code, an NFC label, a Bluetooth identification address and a WIFI identification address corresponding to the role identity code. Wherein the operator is a legal person or a natural person. The identity creation module can also generate a unique identity for each detection device through unique coding technologies such as HASH and MD5 based on the detection device information and an authority timestamp requested during production of the detection device information, and generate a two-dimensional code, an NFC label, a Bluetooth identification address, a WIFI identification address and the like corresponding to the identity.
Specifically, the operator role is connected with the unique identity of the role of the detection device or the detected person through two-dimensional code scanning, NFC connection, Bluetooth or WIFI of the intelligent mobile terminal module, and the role of the detection device or the detected person is bound with the detection activity.
Furthermore, in the embodiment of the invention, the detection result of the detection device can be imaged, and the detection device comprises the colloidal gold test paper, and the detection result of the colloidal gold test paper can be imaged, so that whether the detection result is accurate or not can be obtained by comparing the detection result image with the standard output result image of the colloidal gold. In the embodiment of the invention, the detection information processing module detects the character of the examinee by using the detection equipment according to the use requirement, and shoots the detection result of the detection equipment through the externally-connected or self-carried camera equipment after the detection of the detection equipment is finished, so that the image information of the detection result of the detection equipment is acquired. And then the detection information processing module compares the detection result image information shot by the camera equipment with the standard output result image information of the detection equipment according to an image recognition technology so as to finish the detection of the accuracy of the detection result. The detection information processing module can also judge the integrity and the validity of the detection activity data. The test strip or device that has completed testing may be rejected for secondary use depending on the testing requirements of the testing device.
Further, the operator role also has the ability to create an organization, which can be created with a unique identity by the identity creation module. The organization comprises 4 levels, and each upper level organization can create 100 lower level organizations; i.e. the first level of organization created is 1, the second level thereof comprises 1001The third level comprises 1002A fourth level of organization including 1003The individual level of organization. The four-level organization is used for covering large-scale detection scenes of hospitals, communities and cities; and meanwhile, setting a corresponding unique identity code for each organization. The operator role may assign members to the organization, and may also invite other system users to join the organization to manage various detection activities through the organization.
The detection result output module and the detection information processing module can also summarize detection data of all detection activities and form corresponding map information, and an operator role or an examinee role can acquire the map information through the intelligent mobile terminal module. The operator role or the subject role can quickly check the current detection result overview and the pathogen and antibody transmission condition; meanwhile, the operator can perform combined query through a plurality of dimensions of organization, member, time, pathogen and antibody types, detection results and geographic positions, and can limit viewing of different data according to the identity authority of the role of the operator.
In particular embodiments, the system of the present invention is embodied in software or in APP form. The user can complete role registration through the intelligent mobile terminal of the user, and can select the role to become an operator role or an examinee role according to the functions of the user. The detection equipment is attached with a unique identity identification during production, and when detection activity is carried out, an operator role needs to be in wireless connection with the detection equipment, namely the identity of the operator is bound with the identity of the detection equipment and is calibrated as an operator. When the role of the examinee is detected, wireless connection with the detection equipment is also needed, namely, the own identification is bound with the identification of the detection equipment and is marked as the examinee. The operator role samples the examinee according to the requirement, the detection equipment is used for detecting, the detection result is photographed, all data information of the detection activity is uploaded to the server, and the data of the detection activity comprises photographed detection result image information, operator role identity information, examinee role identity information and relevant information of the detection equipment.
The system also identifies the detection result image uploaded to the server based on an image identification technology, judges the validity of the detection result and simultaneously judges the integrity and validity of the whole submitted data; other operators of the organization or system can detect whether the submitted data is accurate or not and correct the detection result; all the detection data are gathered on a data page and presented to a user in a map form, and the user can quickly check the current detection result overview and the pathogen and antibody transmission condition.
According to the invention, personal intelligent mobile equipment is combined with hardware such as medical colloidal gold test paper and the like through a software system, so that the digital fixing, management, grid connection and monitoring of medical data are realized rapidly. The method comprises the steps of generating unique identification for each detection device, operator and detected person, and establishing contact through wearable hardware devices such as a personal mobile communication smart phone, a tablet personal computer, a smart watch and a smart bracelet. And various connection modes such as two-dimensional codes, NFC, Bluetooth, WIFI and the like are supported. Meanwhile, the method can realize on-site rapid study and report whether individuals are infected by specific pathogens and antibodies and the copy number of the pathogens and the antibodies. The infection condition of individuals, crowds and organizations in a specific space and time dimension is described, dynamically changed and managed. The response of the copy number of the pathogen and the antibody of the individual or the group to the treatment is detected, the data is transmitted to a medical or preventive institution entity, and meanwhile, epidemiological tracing of pathogen and antibody infectors or groups can be realized, and a time and space distribution map is drawn. By the system, at least 2 strips of the colloidal gold test strip can be captured and processed simultaneously, multiple sites corresponding to pathogens and antibodies or detection of multiple pathogens and antibodies can be realized, the sensitivity of pathogen and antibody detection can be improved, and differential diagnosis of multiple pathogens and antibodies can be facilitated.
The following is an example of the detection of the new coronavirus:
using a sample of 50-100 microliters of individual saliva, nasal or pharyngeal swab, adding a viral lysate in a 1: 1, mixing, placing in a digital dry bath heating box, placing at 90 ℃ for 20 minutes, and cooling to room temperature.
5 microliter of the above processed sample is added into a reverse transcription/isothermal amplification system tube and then placed in a digital dry bath heating box for 20 minutes at 42 ℃.
The sample reaction tube is placed at the bottom of a sample clamp with the width of 12 mm and the height of 45 mm, the sample clamp is closed and fastened after the sample reaction tube is placed, and the part, connected with the sample clamp, of the sample reaction tube is 4 mm.
The colloidal gold detection box is 27 mm wide and 65 mm high and is divided into a 15 mm wide reaction chamber with a closed top end and a 12 mm wide sample placing chamber with an opening at the top end, the reaction chamber and the placing chamber are separated, and a gap of 5 mm is arranged at the bottom of the separation.
The reaction chamber of the detection colloidal gold detection box contains 5 mm wide reaction test paper, a 15 mm sample pad is arranged below the test paper, a second test paper detection line is arranged 15 mm above the sample pad, a first test paper detection line is arranged 20 mm above the sample pad, a test paper control line is arranged 25 mm above the sample pad, wherein 2 detection lines develop color for detecting virus positive, 1 detection line develops color for detecting virus negative, and the control line develops color for detecting the effectiveness of the test paper.
The sample clamp with the sample reaction tube is placed in the sample placing chamber of the colloidal gold detection box, the top buckle is pressed downwards and then locked, and the whole colloidal gold detection box is in a completely closed state.
And after the sample reaction tube is punctured, the sample mixed liquid flows into the colloidal gold reaction chamber, and then the colloidal gold is waited for developing for 3 minutes.
The reaction change of the test paper can be shot by a personal intelligent mobile communication device, and a software system captures, studies and judges, reports, transmits data and manages the data.
And performing harmless treatment on the device according to the specifications after reaction.
The colloidal gold test paper is used for detecting pathogens, and a magnetic pad and a magnetic material can be added on the test paper to simultaneously detect the content of the antibody in the sample and improve the detection reliability; or the test paper for detecting the antibody is used instead to directly detect the content of the antibody in the sample, thereby determining the current state of illness or the degree of immunity of the human body. When the antibody is detected, the test paper needs to be put into other magnetic detection equipment, data is read and synchronized into a detection result through a network, so that a user can obtain related detection information and a detection result through the system.
Different from the prior art, the invention provides a pathogen and antibody detection system for a mobile terminal, which ensures the authenticity of a device, a reagent or test paper used as detection equipment from production to detection activity by marking a unique identification code for the detection equipment, ensures the authenticity and validity of identities of an operator and a detected person, and ensures that the detection equipment is directly connected with the detected person or the detected person through an intelligent communication terminal and a wearable intelligent device. Meanwhile, the problem of statistics and management of detection data of loose large-scale social organizations is solved, effectiveness and execution efficiency of detection result judgment are improved through image recognition technology and personnel audit, and pathogen and antibody propagation space-time distribution conditions of various organizations are quickly and visually checked through data presentation. The invention can support large-range, quick and effective pathogen and antibody detection, has simple flow and convenient deployment, and improves the accuracy and the detection efficiency of the pathogen and antibody detection.

Claims (10)

1. A pathogen and antibody detection system for a mobile terminal, comprising:
a detection device for detecting pathogens and antibodies;
the identity creating module is used for creating a unique identity for the detection equipment and creating an operator role or a subject role with the unique identity according to the user information;
the binding module is used for binding the detection equipment, the role of the operator and the role of the detected person with the detection activity according to the detection activity to be carried out;
the detection information processing module is used for acquiring the detection result of the detection equipment and judging the accuracy of the detection result;
and the intelligent mobile terminal module is used for identifying the unique identity of the detection equipment, the role of the operator or the role of the person to be detected and acquiring the data of the detection activity for the role of the operator or the role of the person to be detected.
2. The system of claim 1, wherein the identity creation module generates the identification code corresponding to the operator role or the subject role according to user registration information, mobile phone verification code or LBS information.
3. The system of claim 2, wherein the identity creation module further generates one or more of a two-dimensional code, an NFC tag, a bluetooth identification address, and a WIFI identification address corresponding to the identity code of the identity creation module when creating the operator role or the subject role.
4. The system of claim 3, wherein the operator role binds the role of the detection device or subject to the detection activity by recognizing the unique ID of the role of the detection device or subject through two-dimensional code scanning, NFC connection, Bluetooth or WIFI connection of the smart mobile terminal module.
5. The system of claim 1, wherein the detection information processing module is configured to obtain the detection result image information of the detection device through an image capturing device.
6. The system of claim 5, wherein the detection information processing module compares the image information of the detection result captured by the camera device with the image information of the standard output result of the detection device according to an image recognition technology to complete the verification of the accuracy of the detection result.
7. The system of claim 1, wherein the detection information processing module is further configured to aggregate detection data of all detection activities and form corresponding map information, and the operator role or the subject role can obtain the map information through the smart mobile terminal module.
8. The system of claim 1, wherein the operator role further creates an organization with a unique identity via the identity creation module.
9. The system of claim 8, wherein the organization further creates subordinate organizations to which other operator roles or subject roles can be added.
10. The pathogen and antibody detection system for mobile terminals according to claim 1, wherein said detection device comprises colloidal gold test paper.
CN202010901063.XA 2020-08-31 2020-08-31 Pathogen and antibody detection system for mobile terminal Pending CN111999288A (en)

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CN113453171A (en) * 2021-05-31 2021-09-28 成都健康医联信息产业有限公司 Large-scale emergency detection communication method, device, equipment and storage medium
CN113902146A (en) * 2021-10-19 2022-01-07 杭州臻稀生物科技有限公司 Internet of things detection task issuing method and system
CN113945550A (en) * 2021-10-19 2022-01-18 杭州臻稀生物科技有限公司 Drug detection method and device based on fluorescent colloidal gold

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