CN111989070A - 制作用于眼睛的植入物 - Google Patents
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Abstract
在某些实施例中,一种制作用于眼睛的植入物的系统包括打印机、相机、以及计算机。所述打印机将材料打印到靶上并且具有打印机头和打印机控制器。所述打印机头将所述材料沉积到所述靶上,并且所述打印机控制器移动所述打印机头以将所述材料沉积到所述靶的特定位置上。所述相机生成图像以监测所述材料的打印。所述计算机存储所述植入物的图形,所述植入物被设计用于向所述眼睛提供屈光治疗;向所述打印机控制器发送指令以移动所述打印机头来将所述材料根据所述图形打印到所述靶上;根据所述图形评估来自所述相机的图像;并且响应于所述图像调整所述指令。
Description
技术领域
本披露总体上涉及眼睛的屈光治疗,更具体地涉及制作用于眼睛的植入物。
背景技术
眼睛的屈光治疗是指被执行用于改变眼睛的屈光特性以减小屈光不正来改善视力的技术。当眼睛的某些部分没有正确地弯曲光时,屈光不正发生,从而导致图像模糊。屈光不正的主要类型是近视(近视眼)、远视(远视眼)、老花眼(近视力随年龄而丧失)、以及散光。在一种类型的屈光治疗中使用眼睛植入物。眼睛植入物被植入眼睛中以改变屈光特性来改善视力。
发明内容
在某些实施例中,一种制作用于眼睛的植入物的系统包括打印机、相机、以及计算机。所述打印机将材料打印到靶上并且具有打印机头和打印机控制器。所述打印机头将所述材料沉积到所述靶上,并且所述打印机控制器移动所述打印机头以将所述材料沉积到所述靶的特定位置上。所述相机生成图像以监测所述材料的打印。所述计算机存储所述植入物的图形,所述植入物被设计用于向所述眼睛提供屈光治疗;向所述打印机控制器发送指令以移动所述打印机头来将所述材料根据所述图形打印到所述靶上;根据所述图形评估来自所述相机的图像;并且响应于所述图像调整所述指令。
在某些实施例中,一种制作用于眼睛的植入物的方法包括存储植入物的图形,所述植入物被设计用于向所述眼睛提供屈光治疗。向打印机控制器发送指令以移动打印机头来将材料根据所述图形打印到靶上。生成图像以监测所述材料的打印。根据所述图形评估所述图像并且响应于所述图像调整所述指令。
附图说明
参考附图借助于实例更详细地解释本披露的实施例,在附图中:
图1展示了制作用于眼睛的植入物的系统的实例;
图2展示了制作用于眼睛的植入物的方法的实例,所述方法可以由图1的系统执行;
图3A和图3B展示了可以由图1的系统制作出的具有不同外部形状的植入物的实例;并且
图4A到图4C展示了可以由图1的系统制作出的具有不同内部结构的植入物的实例。
具体实施方式
现在参考说明书和附图,详细示出了所披露的装置、系统、以及方法的示例性实施例。对于本领域普通技术人员而言明显的是,所披露的实施例是示例性的而并非是所有可能的实施例的穷举。
图1展示了制作用于眼睛的植入物12的系统10的实例。系统10包括将生物材料或生物相容性材料打印到靶(比如台14)上的打印机16。计算机22向打印机16发送指令以根据图形20打印材料。图形20被设计用于产生植入物12,所述植入物在被植入眼睛中时向眼睛提供屈光治疗。相机26生成图像以监测材料的打印。计算机22根据图形20评估图像并且可以响应于图像调整指令。在某些实施例中,消融激光器可以使打印材料成形,并且固化照明器28可以使打印材料固化。
在展示的实施例中,系统10包括计算机22、打印机16、台14、消融激光器24、相机26、以及固化照明器28。计算机22包括一个或多个处理器30以及存储图形20的一个或多个存储器32。打印机16包括打印机头34和打印机控制器36。概括来说,在某些实施例中,计算机22控制系统10的部件以根据图形20制作植入物12。台14是作为打印材料的靶或打印材料的靶的支撑物操作的平台。打印机16将材料打印到靶上。消融激光器24消融打印材料以使打印材料根据图形20成形。固化照明器28用促进材料固化的光照射打印材料。相机26生成图像以监测植入物12的产生。为了有助于说明,本说明书参考用于打印的坐标系。在这种坐标系中,打印材料射出的方向限定z轴,并且xy平面是与z轴正交的平面。
植入物12是眼睛植入物,即,通过手术植入眼睛中以向眼睛提供屈光治疗的人工辅助物。当植入物12被植入眼睛中并且眼睛从植入当中恢复时,植入物12改变眼睛的屈光特性以改善视力。植入物12的实例包括角膜嵌入物、角膜覆盖物、人工晶状体、或角膜移植物。在角膜移植物的情况中,系统10产生“供体”组织,所述组织可以包括例如上皮细胞、前弹力细胞、基质细胞和/或内皮细胞等细胞层。可以产生供体组织以用于全厚度角膜移植物(即,穿透性角膜移植术)或后层角膜移植物(即,内皮角膜移植术)。
植入物12可以具有任何合适的尺寸或形状。例如,植入物12可以是直径在0.5毫米到12毫米(mm)的范围内、或在比如0.5mm到5mm、5mm到8mm、或8mm到12mm等子范围内的圆形或环形。在某些实施例中,植入物12可以包括被打印在透明的生物相容性基材上的材料。(这类打印材料的实例在下文描述。)在其他实施例中,植入物12可以包括打印材料、而没有基材。植入物12的有效区域可以是眼睛透视的区域,例如,瞳孔以其最大尺寸所圈起的面积。
图形20描述了植入物20的外部尺寸和形状并且还可以描述植入物20的内部结构。内部结构可以是由打印材料在产生植入物20期间如何沉积、固化、和/或消融所产生的。在某些实施例中,图形20可以限定材料在形成植入物20的每一层上应如何沉积、固化、和/或消融。例如,图形20可以通过描述材料应沉积在哪里、材料是否应以及如何固化、和/或材料是否应以及如何消融来限定第一层应如何制成。图形20可以使用类似类型的描述来限定随后层应如何制成。植入物12、内部结构、以及图形20的实例在图3A到图4C中展示。
打印机16可以是被配置用于使材料根据数字指令沉积到靶上的任何合适的打印机。例如,打印机16可以是3D(或增材制造)打印机,所述打印机沉积连续的材料层以产生被配置成特定形状和尺寸的打印材料。打印机16包括打印机头44和打印机控制器46。打印机头44将材料引导至靶上并且可以是使材料沉积到表面上的任何合适的打印机挤出机。打印机控制器46使打印机头在x、y、z方向上移动以将材料引导至靶的特定位置上、并且可以接收计算机22的指令以根据图形20移动打印机头44。
打印机16打印的材料包括任何合适的生物和/或生物相容性的透明或半透明材料。此类材料的实例包括培养的胶原材料、人或动物细胞材料、生物相容性塑料、透明质酸、重组人胶原III(RHCIII)、明胶丙烯酸甲酯、以及蚕丝。在某些情况下,可以使用上皮细胞可以在其上生长的材料。此类材料可以提供角膜细胞和细胞外材料的最佳营养、整个寿命内的光学透明性、以及上皮细胞生长的支撑性表面特性。
打印机16将材料打印到靶上,所述靶可以是台14或由台14支撑的植入物基材。在某些实施例中,植入物基材可以是使材料的表面成形的模具,所述材料沉积在模具上。模具可以在将植入物12植入眼睛中之前被移除。在其他实施例中,植入物基材可以形成植入物20的一部分,并且与植入物20的其余部分一起被植入到眼睛中。在这些实施例中,如上所述,植入物基材可以包括生物和/或生物相容性的透明或半透明材料。
消融激光器24消融打印材料以使材料根据图形20成形。消融激光器24可以是产生并且发射消融打印材料的激光束的任何合适的激光装置。消融激光器24可以包括产生激光束的激光源(例如,准分子或飞秒)、以及将激光束的焦点引导至靶的特定点的扫描部件(例如,光学器件)。在某些实施例中,激光器24可以包含产生不同激光束的附加激光源,例如,激光器24可以具有产生使打印材料光致破裂或交联的光束以及消融打印材料的光束的源。计算机22可以通过描述应消融哪里的材料来指导消融激光器24以使材料成形。
固化照明器28将固化光引向打印材料以使材料固化。光可以通过促进材料的交联来使材料固化。固化光的实例包括紫外线或在400nm与500nm之间的光(比如LED光)。计算机22可以通过指导材料应什么时候被固化、固化时间和/或固化强度来指导固化照明器28以使材料固化。
相机26生成打印材料的图像以监测材料的打印。相机26可以包括可以生成物体的图像的任何合适的系统。生成OCT扫描以生成图像的光学相干断层成像(OCT)系统(比如时域或频域OCT系统)是相机26的实例。其他实例包括沙伊姆弗勒(Scheimpflug)系统(光截面测量)或立体相机系统。
计算机22向系统10的部件发送指令以告知部件如何操作以根据图形20制作植入物12。例如,计算机22向打印机控制器36发送指令以移动打印机头34来根据图形20打印材料。在某些实施例中,计算机22还可以向消融激光器24发送指令以根据图形20消融打印材料,和/或向固化照明器28发送指令以根据图形20引导固化光。
此外,计算机22评估来自相机26的图像并且可以响应于图像调整指令。计算机22可以根据图形20通过将图像与图形20进行比较以确定图像与图形20之间的差别来评估图像。计算机22可以对图像进行图像处理以识别图像的与植入物12的由图形20限定的同样的特征相对应的特征。这些特征可以是例如外部形状或尺寸或内部结构。比较对应特征以检测出任何差别。如果检测出差别,可以调整指令以减小所述差别。例如,如果图像在图形20指示应没有材料的地方示出了材料,计算机22可以向消融激光器24发送指令以消融不想要的材料。作为另一个实例,如果图像在图形20指示应该有材料的地方显示没有材料,计算机22可以向打印机16发送指令以使更多材料沉积。
计算机22可以在产生植入物12期间的任何合适时间执行评估和调整。例如,计算机22可以连续地执行评估和调整,或可以在某些时间、例如在形成层之后或形成新层之前执行评估和调整。
图2展示了制作用于眼睛的植入物12的方法的实例,所述方法可以由图1的系统10执行。所述方法起始于步骤100,其中,计算机22访问用于制作眼睛植入物12的图形20。在步骤102,计算机22向系统10的部件发送指令以告知部件如何操作以根据图形20制作植入物12。例如,计算机22:在步骤102a向打印机16发送指令以根据图形20打印材料;在步骤102b向固化照明器28发送指令以根据图形20将固化光引向打印材料;和/或在步骤102c向消融激光器24发送指令以根据图形20消融打印材料。
在步骤104,相机26生成打印材料的图像,并且计算机22评估图像。计算机22可以根据图形20通过将图像与图形20进行比较以确定图像的特征(例如,外部形状或尺寸或内部结构)与图形20限定的对应特征之间的差别来评估图像。在步骤106,计算机22确定打印材料是否令人满意。如果不存在差别或特征之间的差别仅是微不足道的,打印材料可以是令人满意的。微不足道的差别可以是在所得视力中不引明显差别的差别。
如果在步骤106打印材料不是令人满意的,那么方法行进到步骤108,其中计算机22响应于图像调整指令。指令可以被调整成减小图像特征与图形特征之间的差别。例如,指令可以被调整成移除不想要的材料或使需要的材料沉积。在第一种情况中,指令可以指导消融激光器24消融不想要的材料。在第二种情况中,指令可以指导打印机16打印需要的材料。
如果在步骤106打印材料是令人满意的,那么方法行进到步骤110,其中计算机22确定植入物形成过程是否结束。如果过程没有结束,那么方法回到步骤102以发送更多指令。如果过程结束,那么方法结束。
图3A和图3B展示了可以由图1的系统10制作出的具有不同外部形状的植入物12的实例。图3A的植入物12a可以用于矫正远视,并且图3B的植入物12b可以用于矫正近视。图3A(1)和图3B(1)分别展示了植入物12a和12b的顶视图,并且图3A(2)和图3B(2)分别展示了植入物12a和图12b的沿着线A-A的截面图。
图4A和图4C展示了可以由图1的系统10制作出的具有不同内部结构的植入物12c到12e的实例。植入物12c到12e由沉积层50制成,所述沉积层可以由植入物12c到12e的图形限定。每个图示出了层50在植入物12的有效区域中的形成。在每个图中:步骤(1)示出了沉积到靶(所述靶可以是台14或植入物基材)上的层50a;步骤(2)示出了沉积到层50a上和/或靶上的层50b;并且步骤(3)示出了沉积到层50b上的层50c。随着每一层50沉积(并且可选地固化和/或消融),形成可以影响植入物12的屈光特性的内部结构。
图4A展示了具有层50的植入物12c,其中每一层50具有基本上相同的厚度。层50a具有均匀曲率,并且随后层50b和50c具有相似的均匀曲率。步骤(4a)和(4b)展示了植入物12c可以如何以不同方式消融以产生不同类型的屈光矫正。步骤(4a)展示了经消融以产生与用于矫正远视的图3A的植入物12a的外部形状相似的外部形状的层50。步骤(4b)展示了经消融以产生与用于矫正近视的图3B的植入物12b的外部形状相似的外部形状的层50。
图4B和图4C展示了具有层50的植入物12d和12e,其中层50a在有效区域上不具有相同的厚度,因此随后层50b和50c不具有与层50a的曲率相似的曲率。在图4B中,层50a沉积在植入物12d的中央区域、而不是外围区域中。随后层50b和50c沉积,这产生的外部形状与用于矫正远视的图3A的植入物12a的外部形状相似。然而,即使植入物12d和图4A的步骤(4a)的植入物12c具有相似外部形状,但它们的内部结构是不同的。
在图4C中,层50a沉积在植入物12e的外围区域、而不是中央区域中。随后层50b和50c沉积,这产生的外部形状与用于矫正近视的图3B的植入物12b的外部形状相似。然而,即使植入物12e和图4A的步骤(4b)的植入物12c具有相似外部形状,但它们的内部结构是不同的。
本文披露的系统和设备的部件(例如,计算机)可以包括界面、逻辑和/或存储器,其中任一个可以包括硬件和/或软件。界面可以接收部件的输入、提供部件的输出、和/或处理输入和/或输出。逻辑可以执行部件的操作,例如,执行指令以由输入生成输出。逻辑可以是处理器,比如一个或多个计算机或一个或多个微处理器。逻辑可以是被编码在存储器中的计算机可执行指令,所述指令可以由计算机、比如计算机程序或软件执行。存储器可以存储信息并且可以包括一个或多个有形、非瞬态、计算机可读、计算机可执行存储介质。存储器的实例包括计算机存储器(例如,随机存取存储器(RAM)或只读存储器(ROM))、大容量存储介质(例如,硬盘)、可移动存储介质(例如,光盘(CD)或数字视频光盘(DVD))、以及网络存储装置(例如,服务器或数据库)。
即使本披露已经就某些实施例进行了描述,但是实施例的修改(比如替换、增加、改变、或省略)对本领域技术人员而言将是显而易见的。因此,可以在不脱离本披露范围的情况下对实施例做出修改。例如,可以对本文披露的系统和设备做出修改。系统和设备的部件可以是一体的或分开的,并且系统和设备的操作可以由更多、更少或其他部件来执行。作为另一个实例,可以对本文披露的方法做出修改。方法可以包括更多、更少或其他步骤,并且步骤可以以任何合适的顺序来执行。
Claims (15)
1.一种制作用于眼睛的植入物的系统,所述系统包括:
打印机,所述打印机被配置用于将材料打印到靶上,所述打印机包括:
打印机头,所述打印机头被配置用于使所述材料沉积到所述靶上,以及
打印机控制器,所述打印机控制器被配置用于移动所述打印机头以使所述材料沉积到所述靶的特定位置上;
相机,所述相机被配置用于生成图像以监测所述材料的打印;
计算机,所述计算机被配置用于:
存储所述植入物的图形,所述植入物被设计用于向所述眼睛提供屈光治疗;
向所述打印机控制器发送指令以移动所述打印机头来将所述材料根据所述图形打印到所述靶上;
根据所述图形评估来自所述相机的图像;以及
响应于所述图像调整所述指令。
2.如权利要求1所述的系统:
进一步包括被配置用于使所述打印材料成形的消融激光器;并且
其中,所述计算机被配置用于向所述消融激光器发送指令以根据所述图形消融所述打印材料。
3.如权利要求1所述的系统,所述相机包括光学相干断层成像(OCT)系统、Scheimpflug系统、或立体相机系统。
4.如权利要求1所述的系统:
进一步包括被配置用于将固化光引向所述打印材料的固化照明器;并且
其中,所述计算机被配置用于向所述固化照明器发送指令以根据所述图形引导所述固化光。
5.如权利要求1所述的系统,其中,所述计算机被配置用于根据所述图形通过将来自所述相机的图像与所述图形进行比较来评估所述图像。
6.如权利要求1所述的系统,其中,所述计算机被配置用于根据所述图形通过以下方式来评估来自所述相机的图像:
识别所述图像中的打印材料的内部结构;并且
将所识别的内部结构与由所述图形限定的内部结构进行比较。
7.如权利要求1所述的系统,其中,所述计算机被配置用于根据所述图形通过以下方式来评估来自所述相机的图像:
识别所述图像中的打印材料的外部形状;并且
将所识别的外部形状与由所述图形限定的外部形状进行比较。
8.如权利要求2所述的系统,其中,所述计算机被配置用于响应于所述图像通过以下方式来调整所述指令:
指导所述消融激光器消融不想要的材料。
9.如权利要求1所述的系统,其中,所述计算机被配置用于响应于所述图像通过以下方式来调整所述指令:
指导所述打印机打印需要的材料。
10.如权利要求1所述的系统,所述材料包括生物材料或生物相容性材料。
11.如权利要求1所述的系统,所述靶包括台或植入物基材。
12.一种制作用于眼睛的植入物的方法,所述方法包括:
存储植入物的图形,所述植入物被设计用于向所述眼睛提供屈光治疗;
向打印机控制器发送指令以移动打印机头来将材料根据所述图形打印到靶上;
生成图像以监测所述材料的打印;
根据所述图形评估所述图像;以及
响应于所述图像调整所述指令。
13.如权利要求12所述的方法,进一步包括向消融激光器发送指令以根据所述图形消融所述打印材料。
14.如权利要求12所述的方法,进一步包括向固化照明器发送指令以根据所述图形引导固化光。
15.如权利要求12所述的方法,其中,根据所述图形评估所述图像包括:
识别所述图像中的打印材料的内部结构;以及
将所识别的内部结构与所述图形限定的内部结构进行比较。
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2019
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- 2019-04-12 US US16/383,007 patent/US11357615B2/en active Active
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AU2019254043A1 (en) | 2020-09-03 |
CA3090940A1 (en) | 2019-10-24 |
TW201944972A (zh) | 2019-12-01 |
JP2021518200A (ja) | 2021-08-02 |
JP2024050744A (ja) | 2024-04-10 |
US11357615B2 (en) | 2022-06-14 |
EP3781083A1 (en) | 2021-02-24 |
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