CN111982818A - Device for detecting liquid crystal droplet optical digital signal and application thereof - Google Patents
Device for detecting liquid crystal droplet optical digital signal and application thereof Download PDFInfo
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- CN111982818A CN111982818A CN202010752963.2A CN202010752963A CN111982818A CN 111982818 A CN111982818 A CN 111982818A CN 202010752963 A CN202010752963 A CN 202010752963A CN 111982818 A CN111982818 A CN 111982818A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
Abstract
The invention relates to a device for detecting liquid crystal droplet optical digital signals and application thereof, comprising a display, and a detector, a light gathering tube, an analyzer, a sample groove and a bottom plate which are sequentially connected from top to bottom; the sample groove is a cavity cylinder, a partition plate is arranged in the cavity cylinder, a light through hole is formed in the center of the partition plate, the partition plate divides the inner space of the cavity cylinder into an upper cavity and a lower cavity, an opening is formed in the side wall of the upper cavity, and a polarizer, a light homogenizing plate and a light source are placed in the lower cavity. The detection device of the invention uses liquid crystal liquid drops as sensing elements to detect the target objects, mainly comprising biomolecules such as enzyme, protein, micromolecule and the like, and chemical substances such as heavy metal, inorganic pollutants, organic pollutants and the like. The method has the advantages of strong portability, real-time dynamic detection, high detection efficiency, small sample volume and the like, and avoids the defects that the traditional detection needs large-scale laboratory instruments, the data processing is complex and the like.
Description
Technical Field
The invention relates to a device for detecting an optical digital signal of liquid crystal droplets and application thereof, belonging to the technical field of sensing detection equipment.
Background
Because the liquid crystal material has liquid fluidity and crystal anisotropy, especially optical anisotropy, a recognition unit is modified on a liquid-liquid interface or a liquid-solid interface of the liquid crystal, the recognition unit recognizes a target object, the arrangement of liquid crystal molecules is changed, a polarization signal changes from light to dark or from dark to light, and the rapid, sensitive and portable detection of the target object or the recognition of response to external stimulation can be realized. The target substance mainly comprises biomolecules such as enzymes, proteins, small molecules and the like, and chemical substances such as heavy metals, inorganic pollutants, organic pollutants and the like. The external stimulus response includes heat, electricity, magnetism, etc. Therefore, the field of detection based on the liquid crystal sensing principle is vigorously developed.
However, for quantitative or qualitative detection of the concentration of a target, it is often necessary to capture images of a polarization signal by means of a polarization microscope, for example, chinese patent document CN110554493A provides a polarization reading microscope comprising: eyepiece, lens cone remove adjustment mechanism, objective, base, wafer holder, work platen and connection the base with the lens cone removes adjustment mechanism's pillar group, be equipped with the orientation in the base the light source that the lens cone set up, the top of light source is equipped with can dismantle the connection the polarizer of base, the periphery cover of objective be equipped with polarizer complex analyzer. The polarized light reading microscope can be used as a common optical microscope and can also be used as a polarized light microscope, so that one microscope is multipurpose, and the equipment cost and the equipment occupation space are reduced. And then, gray value or brightness ratio calculation is carried out through Image processing software such as Image J or Photoshop, data results need to be converted, and the steps are complicated. The liquid crystal droplet detection realizes semi-quantitative detection of a target object by changing the liquid droplet appearance such as direct change from a 'maltese cross' appearance to a 'fan-shaped' appearance, and because the liquid crystal droplet is small in size and is about micron-scale, an image obtained by a polarizing microscope is changed in a small range, and a representative description cannot be made on a sample.
However, the conventional polarizing microscope has high cost, high price and complex structure, is suitable for being used in indoor environments such as laboratories, is not convenient to carry outdoors, and cannot realize instant rapid detection. Therefore, it is urgently needed to develop a portable detection device based on the liquid crystal sensing principle, which can directly read the detection result, so as to realize the rapid real-time detection of the target object.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a device for detecting the liquid crystal droplet optical digital signal, which is convenient to carry, is convenient for realizing outdoor detection or home self-detection, and is convenient for maintaining instruments and replacing consumables.
The technical scheme of the invention is as follows:
a device for detecting liquid crystal droplet optical digital signals comprises a display, and a detector, a light-gathering tube, an analyzer, a sample groove and a bottom plate which are sequentially connected from top to bottom, wherein the display is electrically connected with the detector;
the sample groove is a cavity cylinder, a partition plate is arranged in the cavity cylinder, a light through hole is formed in the center of the partition plate, the partition plate divides the inner space of the cavity cylinder into an upper cavity and a lower cavity, an opening is formed in the side wall of the upper cavity, and a polarizer, a light homogenizing plate and a light source are placed in the lower cavity.
Preferably, the light source is an LED light source with adjustable light intensity.
Preferably, the LED light source is a circular or annular light source with power of 1-5W.
Preferably, the light emitting angle of the LED light source is 60-120 degrees.
Preferably, the distance between the light source and the light through hole is 3-15 cm. The advantage of this design is that maintaining a reasonable distance reduces the interference of the thermal effects generated by the light source on the sample.
Preferably, the center of the light through hole is coaxial with the center of the light source. The advantage of this design is, places detection samples such as liquid crystal liquid drop in the upper chamber, and the illumination that sends through the light source directly passes coaxial logical unthreaded hole, shines on the liquid crystal liquid drop, and the light source center is coaxial with logical unthreaded hole, is convenient for detect.
Preferably, the polarizer and the analyzer have polarization optical axis angles of 90 ° orthogonal to each other. The 90-degree cross refers to the direction of the polarization optical axis of the analyzer relative to the direction of the polarization optical axis of the polarizer.
Preferably, the analyzer comprises a polaroid, a pressure ring and a rotating assembly, the polaroid is sealed in the pressure ring, the pressure ring can be detached, and the angle of an optical axis of the polaroid can be adjusted through the rotating assembly. The benefit of this design is, in the long-term use, impurity in the environment causes the pollution easily, and polarisation subassembly needs regularly to wash or change, through the detachable clamping ring, makes things convenient for the change of polaroid, adjusts to 90 through the relative polarizer polaroid optical axis angle of the adjustable polaroid polarisation optical axis of rotatory subassembly.
Preferably, the polarizer comprises a polaroid and a pressure ring, the polaroid is sealed in the pressure ring, and the pressure ring can be detached. The advantage of this design is, in the long-term use, because the impurity in the environment, polarisation subassembly needs regularly to wash or change, through the detachable clamping ring, makes things convenient for the change of polaroid.
Preferably, the distance between the light homogenizing plate and the light source is 1-3 cm.
Preferably, the distance between the light-gathering cylinder and the sample groove is 5-20 cm.
Preferably, the device further comprises an optical isolation plate, and the width of the optical isolation plate is larger than the diameter of the light through hole. The advantage of this design is that the light baffle can be inserted into the upper chamber of the sample slot from the opening to cover the light through hole.
A method of using an apparatus for detecting liquid crystal droplet optical digitized signals, comprising the steps of:
step one, zero point calibration:
turning on a light source, fixing the intensity of the light source, placing a light-isolating plate in a sample groove, wherein a light source light signal on an optical axis sequentially passes through a light homogenizing plate, a polarizer, the light-isolating plate and an analyzer, the light intensity is detected by a detector, and the display reading is zero at the moment; then removing the light-isolating plate, keeping the reading to be zero, if not, the relative angle of the polarizer and the analyzer is deviated, and the deflection angle of the analyzer needs to be adjusted to ensure that the reading of the display is zero; then the light isolation plate is inserted into the sample groove, and the reading is still zero; the deflection angle of the analyzer is adjusted through the steps, so that the base and the environment of the sample tank are guaranteed to have no influence on the zero point of illumination;
step two, preparation of sensing elements:
the sensing element is a liquid crystal droplet fixed on a substrate, wherein the substrate is a hydrophobic interface, the liquid crystal droplet is anchored on the hydrophobic interface, and because liquid crystal molecules in the liquid crystal droplet are vertically arranged under the induction of air and the hydrophobic interface together and cannot deflect incident polarized light, the illumination value of a sample at the moment is zero;
doping or modifying liquid crystal droplets by designing detection methods of different substances including but not limited to enzymes, small molecules and heavy metals to obtain sensing elements with specific recognition;
step three, sample testing:
dripping 1 μ L of sample containing target substance onto the specific identified sensing element, taking down the light-isolating plate, inserting the sensing element into the sample groove, changing the arrangement of liquid crystal molecules, and detecting the change of 0-1 or 1-0 detection signal within 5-10min, wherein 0 represents zero illuminance value, 1 represents reading number of illuminance value, and the detection limit of the sensing element is 10-9And the following.
The invention has the beneficial effects that:
1. the detection device has the advantages of strong portability, real-time dynamic detection, high detection efficiency, small required sample volume and the like in the aspect of detecting biological substances by taking liquid crystal droplets as sensing elements, and avoids the defects of the traditional detection that a laboratory large instrument is required, the data processing is complex and the like.
2. The device combination of the liquid crystal droplet detection device is mainly integrated equipment and an auxiliary module for regular maintenance, and the polarizer, the polarization analyzer and the like are replaceable and detachable units, so that the maintenance of the instrument and the replacement of consumables are facilitated.
3. The detection device disclosed by the invention is based on the principle of an illuminometer, and realizes real-time digital statistics of detection data results according to the identification of liquid crystal droplets on a target object.
4. The detection device provided by the invention is simple in process, can be used as a liquid crystal sensing portable detection device to realize outdoor detection or home self-detection, has good economic value and social benefit, and is worthy of popularization and application.
Drawings
FIG. 1 is a schematic structural diagram of a detecting device according to the present invention;
FIG. 2 is a perspective view of a sample cell according to the present invention;
FIG. 3 is a front view of a sample cell according to the present invention;
FIG. 4 is a top view of a sample cell according to the present invention;
FIG. 5 is a perspective view of a light barrier according to the present invention;
wherein: 1-detector, 2-condenser, 3-analyzer, 4-sample groove, 5-bottom plate, 6-opening, 7-display, 8-light through hole, 9-upper chamber and 10-light isolating plate.
Detailed Description
The present invention will be further described by way of examples, but not limited thereto, with reference to the accompanying drawings.
Example 1:
as shown in fig. 1, the present embodiment provides an apparatus for detecting an optical digitized signal of a liquid crystal droplet, which includes a display 7, and a detector 1, a light-focusing tube 2, an analyzer 3, a sample tank 4, and a bottom plate 5, which are sequentially connected from top to bottom, wherein the display 7 is electrically connected to the detector 1, and the display 7, the detector 1, and the light-focusing tube 2 form an illuminometer as a whole;
the sample groove 4 is a cavity cylinder, a partition plate is arranged in the cavity cylinder, a light through hole 8 is formed in the center of the partition plate, the partition plate divides the inner space of the cavity cylinder into an upper cavity and a lower cavity, an opening 6 is formed in the side wall of the upper cavity, and a polarizer, a light homogenizing plate and a light source are placed in the lower cavity.
Wherein the analyzer 3 and the sample holder 4 are glued together. The light source, the light homogenizing plate and the polarizer are placed in the lower cavity, then the bottom plate 5 is directly plugged into the bottom end of the lower cavity for packaging, and the side wall of the upper cavity is symmetrically provided with two openings 6 for conveniently placing the light isolating plate or the sensing element.
Both the detector 1 and the condenser tube 2 constitute the illuminometer section. The light source is an LED circular light source with adjustable light intensity, the power is 1W, and the light emitting angle of the LED light source is 60-120 degrees.
The distance between the light through hole 8 and the light source is 3-15 cm. The two are kept at a certain reasonable distance, so that the interference of the heat effect generated by the light source to the sample can be reduced.
The display 7, the detector 1 and the light-gathering cylinder 2 form a commercially available product illuminometer, the manufacturer and the model are Taiwan Shistes-137, and the distance between the light-gathering cylinder 2 and the sample groove 4 is 5-20 cm.
The light through hole 8 of the sample groove is coaxial with the center of the light source. Sensing elements such as liquid crystal liquid drops and the like can be placed in the upper cavity for sample detection, light emitted by the light source directly penetrates through the coaxial light through hole 8 to irradiate on the liquid crystal liquid drops, and the center of the light source is coaxial with the center of the light through hole, so that detection is facilitated.
The polarizer and analyzer 3 is mainly composed of linear polarizers, and the polarized light axis angles of the polarizer and the analyzer are orthogonal 90 degrees. The 90-degree cross refers to the direction of the polarization optical axis of the analyzer relative to the direction of the polarization optical axis of the polarizer.
Specifically, analyzer 3 includes polaroid, clamping ring and rotating assembly, and the polaroid seals in the clamping ring, and the clamping ring can be dismantled, adjusts the optical axis angle of polaroid through rotating assembly. In the long-term use, because the impurity in the environment, polarisation subassembly needs regularly to wash or change, through the detachable clamping ring, makes things convenient for the change of polaroid, through the relative polarizer polaroid optical axis angle of the adjustable polaroid polarisation optical axis of rotating assembly, adjusts to 90, crushes by pressure and rotating assembly are conventional equipment.
The polarizer comprises a polaroid and a pressure ring, the polaroid is sealed in the pressure ring, and the pressure ring can be detached. In the long-term use, because the impurity in the environment, polarisation subassembly needs regularly to wash or change, through detachable clamping ring, makes things convenient for the change of polaroid.
The distance between the light homogenizing sheet and the light source is 1-3cm, and the light homogenizing sheet, the light source and the polarizer are fixed through gluing or nuts.
The detection device also comprises a light-isolating plate 10, and the width of the light-isolating plate 10 is larger than the diameter of the light-passing hole. The light-shielding plate 10 is a black strip plate, and can be inserted into the upper chamber of the sample slot from the opening to cover the light-passing hole.
The working principle of the invention is as follows:
the photoelectric conversion principle and the liquid crystal anisotropy principle are combined, an optical signal of a liquid crystal detection target object is converted into an electrical signal through a photoelectric conversion element, and the datamation of a liquid crystal sensing detection result of the target object is achieved.
Example 2:
example 1 was repeated with the following differences: the LED light source is a ring light source with power of 5W.
Example 3:
the device for detecting the optical digital signal of the liquid crystal droplet in the embodiment 1 is used for qualitatively detecting the surfactant, and the detection method comprises the following steps:
step one, zero point calibration:
turning on a light source, fixing the intensity of the light source, placing a light-isolating plate in a sample groove, wherein a light source light signal on an optical axis sequentially passes through a light homogenizing plate, a polarizer, the light-isolating plate and an analyzer, the light intensity is detected by a detector, and the display reading is zero at the moment; then removing the light-isolating plate, keeping the reading to be zero, if not, the relative angle of the polarizer and the analyzer is deviated, and the deflection angle of the analyzer needs to be adjusted to ensure that the reading of the display is zero; then the light isolation plate is inserted into the sample groove, and the reading is still zero; the deflection angle of the analyzer is adjusted through the steps, so that the base and the environment of the sample tank are guaranteed to have no influence on the zero point of illumination;
step two, preparation of sensing elements:
the sensing element is a liquid crystal material such as 4-cyano-4' -pentylbiphenyl (5CB) or mixed liquid crystal (E7) and the like, and is prepared into uniform liquid crystal droplets by a solvent volatilization method, an ink-jet printing method and the like, and the substrate is a hydrophobic interface modified by materials such as octadecyl trichlorosilane-heptane (OTS), N-dimethyl-N-octadecyl-3-aminopropyl trimethyl silyl chloride (DMOAP) and the like;
step three, sample testing:
mu.L of a buffered salt solution containing no surfactant (sample 1) and 1. mu.L of buffered salt solutions containing different concentrations of surfactant (samples 2 to 5, concentrations of 0.001mM,0.01mM,0.1mM,1mM, respectively) were added dropwise to the sensor element, respectively. The sensing element is placed in the sample tank and is read through a display. The sample 1 induces the liquid crystal molecule arrangement to change, and presents a 'maltese cross' shape; the surfactant in the samples 2-5 has hydrophobic effect with the liquid crystal molecules to induce the liquid crystal molecules to be directionally arranged along the interface, so that the appearance of the liquid crystal droplets gradually changes from a 'maltese cross' appearance to a 'fan-shaped' appearance along with the increase of the concentration of the surfactant, the display shows a trend of first decreasing and then increasing, and the qualitative detection of the surfactant is realized through an illuminance-concentration trend graph.
Example 4:
the device for detecting the liquid crystal droplet optical digital signal in the embodiment 1 is used for detecting the lysozyme, and the detection method comprises the following steps:
step one, zero point calibration:
turning on a light source, fixing the intensity of the light source, placing a light-isolating plate in a sample groove, enabling light source light signals on an optical axis to sequentially pass through a light homogenizing plate, a polarizer, the light-isolating plate and an analyzer, detecting the light intensity through a detector, and enabling the display to have zero reading at the moment; then removing the light-isolating plate, keeping the reading value as zero, if not, the relative angle of the polarizer and the analyzer is deviated, and the deflection angle of the analyzer needs to be adjusted to ensure that the reading value of the display is zero; then the light isolation plate is inserted into the sample groove, and the reading is still zero; the deflection angle of the analyzer is adjusted through the steps, so that the base and the environment of the sample tank are guaranteed to have no influence on the zero point of illumination;
step two, preparation of sensing elements:
the sensing element is a liquid crystal material such as 4-cyano-4' -pentylbiphenyl (5CB) or mixed liquid crystal (E7) and the like, and is prepared into uniform liquid crystal droplets by a solvent volatilization method, an ink-jet printing method and the like, and the substrate is a hydrophobic interface modified by materials such as octadecyl trichlorosilane-heptane (OTS), N-dimethyl-N-octadecyl-3-aminopropyl trimethyl silyl chloride (DMOAP) and the like;
step three, sample testing:
the detection of the liquid crystal droplets on the lysozyme is realized by utilizing the specific hydrolysis of the lysozyme on the dodecyl glucopyranoside. The sensing element responds to the dodecyl glucopyranoside solutions with different concentrations, the concentration of the dodecyl glucopyranoside solution with the illumination value of 0 is screened out, lysozyme with different concentrations and the dodecyl glucopyranoside solution with the concentration are incubated at constant temperature and then are used as samples to be added to the sensing element, the sensing element is placed in a sample tank, and the reading is carried out through a display. When the concentration of the lysozyme is more than or equal to 0.01mg/mL, namely the activity is more than or equal to 200U/mL, the display value is more than 0, and after other enzymes are incubated with the dodecyl glucopyranoside solution with the same concentration, the display value is still 0, so that the rapid and specific detection of the lysozyme is realized.
The above description is only for the specific embodiments of the present invention, and the protection scope of the present invention is not limited thereto, and any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope of the present invention are included in the protection scope of the present invention.
Claims (10)
1. A device for detecting liquid crystal droplet optical digital signals is characterized by comprising a display, a detector, a light gathering tube, an analyzer, a sample groove and a bottom plate, wherein the detector, the light gathering tube, the analyzer, the sample groove and the bottom plate are sequentially connected from top to bottom;
the sample groove is a cavity cylinder, a partition plate is arranged in the cavity cylinder, a light through hole is formed in the center of the partition plate, the partition plate divides the inner space of the cavity cylinder into an upper cavity and a lower cavity, an opening is formed in the side wall of the upper cavity, and a polarizer, a light homogenizing plate and a light source are placed in the lower cavity.
2. The apparatus for detecting the optical digitized signal of a liquid crystal droplet of claim 1 wherein the light source is an LED light source with adjustable light intensity.
3. The apparatus for detecting the optical digitized signal of a liquid crystal droplet of claim 2 wherein the LED light source has an angle of illumination of between 60 ° and 120 °.
4. The apparatus for detecting the optical digitized signal of a liquid crystal droplet of claim 1 wherein the light source is spaced from the clear aperture by a distance of 3 to 15 cm.
5. The apparatus for detecting the optical digitized signal of a liquid crystal droplet of claim 1 wherein the center of the light aperture is coaxial with the center of the light source.
6. The apparatus for detecting the optical digitized signal of a liquid crystal droplet of claim 1 wherein the polarizer and analyzer have polarization optic axes at 90 ° to each other.
7. The apparatus according to claim 1, wherein the analyzer comprises a polarizer, a pressing ring, and a rotating assembly, the polarizer is enclosed in the pressing ring, the pressing ring is removable, and the rotating assembly adjusts the angle of the optical axis of the polarizer.
8. The apparatus according to claim 1, wherein the polarizer comprises a polarizer and a pressure ring, the polarizer is enclosed in the pressure ring, and the pressure ring is removable.
9. The device for detecting the optical digitized signal of a liquid crystal droplet of claim 1 further comprising an opaque plate having a width greater than the diameter of the light passing aperture.
10. Use of a device for detecting the optical digitisation signal of a liquid crystal drop according to any of claims 1-9, characterised in that it comprises the following steps:
step one, zero point calibration:
turning on a light source, fixing the intensity of the light source, placing a light-isolating plate in a sample groove, wherein a light source light signal on an optical axis sequentially passes through a light homogenizing plate, a polarizer, the light-isolating plate and an analyzer, the light intensity is detected by a detector, and the display reading is zero at the moment; then removing the light-isolating plate, keeping the reading to be zero, if not, the relative angle of the polarizer and the analyzer is deviated, and the deflection angle of the analyzer needs to be adjusted to ensure that the reading of the display is zero; then the light isolation plate is inserted into the sample groove, and the reading is still zero; the deflection angle of the analyzer is adjusted through the steps, so that the base and the environment of the sample tank are guaranteed to have no influence on the zero point of illumination;
step two, preparation of sensing elements:
the sensing element is a liquid crystal droplet fixed on a substrate, wherein the substrate is a hydrophobic interface, the liquid crystal droplet is anchored on the hydrophobic interface, and because liquid crystal molecules in the liquid crystal droplet are vertically arranged under the induction of air and the hydrophobic interface together and cannot deflect incident polarized light, the illumination value of a sample at the moment is zero;
doping or modifying liquid crystal droplets by designing detection methods of different substances including but not limited to enzymes, small molecules and heavy metals to obtain sensing elements with specific recognition;
step three, sample testing:
dripping 1 μ L of sample containing target substance onto the specific identified sensing element, taking down the light-isolating plate, inserting the sensing element into the sample groove, changing the arrangement of liquid crystal molecules, and detecting the change of 0-1 or 1-0 detection signal within 5-10min, wherein 0 represents zero illuminance value, 1 represents reading number of illuminance value, and the detection limit of the sensing element is 10-9And the following.
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Application publication date: 20201124 |