CN111956700A - Antrodia camphorata anti-alcohol pill and preparation method thereof - Google Patents
Antrodia camphorata anti-alcohol pill and preparation method thereof Download PDFInfo
- Publication number
- CN111956700A CN111956700A CN202010883754.1A CN202010883754A CN111956700A CN 111956700 A CN111956700 A CN 111956700A CN 202010883754 A CN202010883754 A CN 202010883754A CN 111956700 A CN111956700 A CN 111956700A
- Authority
- CN
- China
- Prior art keywords
- antrodia camphorata
- parts
- pill
- antrodia
- vitamin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241001486992 Taiwanofungus camphoratus Species 0.000 title claims abstract description 216
- 239000006187 pill Substances 0.000 title claims abstract description 101
- 230000002075 anti-alcohol Effects 0.000 title claims abstract description 17
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 118
- 239000000284 extract Substances 0.000 claims abstract description 77
- 150000001413 amino acids Chemical class 0.000 claims abstract description 30
- 244000010000 Hovenia dulcis Species 0.000 claims abstract description 24
- 235000008584 Hovenia dulcis Nutrition 0.000 claims abstract description 24
- 229940088594 vitamin Drugs 0.000 claims abstract description 23
- 229930003231 vitamin Natural products 0.000 claims abstract description 23
- 235000013343 vitamin Nutrition 0.000 claims abstract description 23
- 239000011782 vitamin Substances 0.000 claims abstract description 23
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 14
- 244000046146 Pueraria lobata Species 0.000 claims abstract description 12
- 235000010575 Pueraria lobata Nutrition 0.000 claims abstract description 12
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 9
- 239000003765 sweetening agent Substances 0.000 claims abstract description 9
- 239000003381 stabilizer Substances 0.000 claims abstract description 7
- 239000000796 flavoring agent Substances 0.000 claims abstract description 6
- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 235000019441 ethanol Nutrition 0.000 claims description 88
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 46
- 239000000843 powder Substances 0.000 claims description 40
- 238000002156 mixing Methods 0.000 claims description 37
- 239000000706 filtrate Substances 0.000 claims description 33
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 32
- 235000001014 amino acid Nutrition 0.000 claims description 28
- 239000000469 ethanolic extract Substances 0.000 claims description 24
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 18
- 238000001914 filtration Methods 0.000 claims description 17
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 16
- 229930006000 Sucrose Natural products 0.000 claims description 16
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 16
- 229930003268 Vitamin C Natural products 0.000 claims description 16
- 235000012907 honey Nutrition 0.000 claims description 16
- 235000019154 vitamin C Nutrition 0.000 claims description 16
- 239000011718 vitamin C Substances 0.000 claims description 16
- 210000000582 semen Anatomy 0.000 claims description 15
- 239000005720 sucrose Substances 0.000 claims description 15
- 229920001285 xanthan gum Polymers 0.000 claims description 15
- 239000000230 xanthan gum Substances 0.000 claims description 15
- 229940082509 xanthan gum Drugs 0.000 claims description 15
- 235000010493 xanthan gum Nutrition 0.000 claims description 15
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 14
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 14
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 14
- 235000004279 alanine Nutrition 0.000 claims description 14
- 206010019133 Hangover Diseases 0.000 claims description 12
- 229930003451 Vitamin B1 Natural products 0.000 claims description 11
- 229960003495 thiamine Drugs 0.000 claims description 11
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 11
- 235000010374 vitamin B1 Nutrition 0.000 claims description 11
- 239000011691 vitamin B1 Substances 0.000 claims description 11
- 239000006228 supernatant Substances 0.000 claims description 10
- 238000005303 weighing Methods 0.000 claims description 10
- 238000009835 boiling Methods 0.000 claims description 9
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 9
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 9
- 235000019158 vitamin B6 Nutrition 0.000 claims description 9
- 239000011726 vitamin B6 Substances 0.000 claims description 9
- 229940011671 vitamin b6 Drugs 0.000 claims description 9
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 8
- 241000234435 Lilium Species 0.000 claims description 8
- 235000014676 Phragmites communis Nutrition 0.000 claims description 8
- 238000010992 reflux Methods 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 238000005360 mashing Methods 0.000 claims description 7
- 238000001704 evaporation Methods 0.000 claims description 6
- 238000001291 vacuum drying Methods 0.000 claims description 6
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 2
- 238000005520 cutting process Methods 0.000 claims description 2
- 235000013399 edible fruits Nutrition 0.000 claims description 2
- 229940010454 licorice Drugs 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 80
- 208000007848 Alcoholism Diseases 0.000 abstract description 56
- 201000007930 alcohol dependence Diseases 0.000 abstract description 56
- 210000004185 liver Anatomy 0.000 abstract description 23
- 239000000126 substance Substances 0.000 abstract description 19
- 210000002784 stomach Anatomy 0.000 abstract description 16
- 210000000952 spleen Anatomy 0.000 abstract description 6
- 235000019658 bitter taste Nutrition 0.000 abstract description 3
- 238000000354 decomposition reaction Methods 0.000 abstract description 3
- 238000001727 in vivo Methods 0.000 abstract description 3
- 210000000056 organ Anatomy 0.000 abstract description 3
- 235000019640 taste Nutrition 0.000 abstract description 3
- 230000029142 excretion Effects 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract description 2
- 241000699670 Mus sp. Species 0.000 description 56
- 241000699666 Mus <mouse, genus> Species 0.000 description 32
- 239000007788 liquid Substances 0.000 description 18
- 229960004793 sucrose Drugs 0.000 description 15
- 150000003648 triterpenes Chemical class 0.000 description 14
- 230000000052 comparative effect Effects 0.000 description 13
- 229930003270 Vitamin B Natural products 0.000 description 12
- 239000013543 active substance Substances 0.000 description 12
- 150000003505 terpenes Chemical class 0.000 description 12
- 235000019156 vitamin B Nutrition 0.000 description 12
- 239000011720 vitamin B Substances 0.000 description 12
- 230000004060 metabolic process Effects 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 230000001476 alcoholic effect Effects 0.000 description 9
- 239000003651 drinking water Substances 0.000 description 9
- 235000020188 drinking water Nutrition 0.000 description 9
- 241000219071 Malvaceae Species 0.000 description 8
- 239000006286 aqueous extract Substances 0.000 description 8
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 7
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 7
- 244000068988 Glycine max Species 0.000 description 7
- 235000010469 Glycine max Nutrition 0.000 description 7
- 244000303040 Glycyrrhiza glabra Species 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 238000000855 fermentation Methods 0.000 description 7
- 230000004151 fermentation Effects 0.000 description 7
- 230000002195 synergetic effect Effects 0.000 description 7
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 6
- 235000011477 liquorice Nutrition 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 229960003767 alanine Drugs 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 229960003136 leucine Drugs 0.000 description 5
- 235000005772 leucine Nutrition 0.000 description 5
- 238000004458 analytical method Methods 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000000857 drug effect Effects 0.000 description 4
- 150000004676 glycans Chemical class 0.000 description 4
- 230000036039 immunity Effects 0.000 description 4
- 230000003647 oxidation Effects 0.000 description 4
- 238000007254 oxidation reaction Methods 0.000 description 4
- 229920001282 polysaccharide Polymers 0.000 description 4
- 239000005017 polysaccharide Substances 0.000 description 4
- 210000002966 serum Anatomy 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 238000010998 test method Methods 0.000 description 4
- XBZYWSMVVKYHQN-MYPRUECHSA-N (4as,6as,6br,8ar,9r,10s,12ar,12br,14bs)-10-hydroxy-2,2,6a,6b,9,12a-hexamethyl-9-[(sulfooxy)methyl]-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid Chemical compound C1C[C@H](O)[C@@](C)(COS(O)(=O)=O)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C XBZYWSMVVKYHQN-MYPRUECHSA-N 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 206010067125 Liver injury Diseases 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 230000035622 drinking Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical group CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010019668 Hepatic fibrosis Diseases 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 240000007313 Tilia cordata Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 231100000753 hepatic injury Toxicity 0.000 description 2
- 210000000936 intestine Anatomy 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000018102 proteins Nutrition 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000010298 pulverizing process Methods 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000028527 righting reflex Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010016952 Food poisoning Diseases 0.000 description 1
- 208000019331 Foodborne disease Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 240000008397 Ganoderma lucidum Species 0.000 description 1
- 235000001637 Ganoderma lucidum Nutrition 0.000 description 1
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 238000004737 colorimetric analysis Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 150000004141 diterpene derivatives Chemical class 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000011194 food seasoning agent Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 231100000234 hepatic damage Toxicity 0.000 description 1
- 230000002443 hepatoprotective effect Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000035987 intoxication Effects 0.000 description 1
- 231100000566 intoxication Toxicity 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000008818 liver damage Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000010979 ruby Substances 0.000 description 1
- 229910001750 ruby Inorganic materials 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009044 synergistic interaction Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Toxicology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses antrodia camphorate anti-alcoholism pill and a preparation method thereof, wherein the antrodia camphorate anti-alcoholism pill is mainly prepared from the following raw materials in parts by weight: 40-60 parts of antrodia camphorata alcohol extract, 7-11 parts of hovenia dulcis thunb, 5-8 parts of kudzu root, 1-3 parts of vitamin, 1-3 parts of amino acid, 6-10 parts of stabilizer, 5-10 parts of sweetener and 2-5 parts of flavoring agent. The main effective component of the invention is antrodia camphorata alcohol extract, and hovenia dulcis thunb, radix puerariae, amino acid, vitamin and other antialcoholic substances are added, so that the effect of learning to drink is further improved. Meanwhile, substances such as a sweetening agent, a flavoring agent and the like are added, so that the bitter taste of the antrodia camphorata sobering-up pill is fully covered, and the taste of the antrodia camphorata sobering-up pill is obviously improved. The components in the formula are safe, have no side effect, can accelerate the decomposition and excretion of alcohol in vivo, and simultaneously have good effects of protecting liver, spleen, stomach and other organs.
Description
Technical Field
The invention belongs to an anti-alcoholism medicine, and particularly relates to an anti-alcoholism antrodia camphorata pill and a preparation method thereof.
Background
Drinking is one of the indispensable recreational activities throughout the world. Chinese people have no discolouration until now, and have the saying that the people have the feast and must have the wine, and the people do not have the inscription of the wine. However, drinking high alcohol over 25mL a day can damage the liver. Excessive drinking can damage the spleen and stomach, causing weakness of the spleen and stomach. Spleen deficiency failing to transport and transform, alcohol-dampness and turbid-qi accumulating in the middle energizer, mixing of clear and turbid-qi and obstructing qi flow. Unsmooth blood circulation, damp turbidity and qi and blood are mixed in the liver to cause liver damage and liver disease. Impairment of the liver, abnormal flow of qi, disharmony of the zang-fu organs, stagnation of qi and blood, and spleen deficiency, which may lead to kidney failure, opening and closing of the kidney, and accumulation of turbid water, which is usually not discharged, are known as kidney diseases.
Antrodia cinnamomea (Antrodia cinnamomea), also known as Antrodia cinnamomea or Antrodia cinnamomea, is a rare medicinal and edible fungus, and has the reputation of forest ruby. In early stage, people often use the antrodia camphorata to treat hangover, food poisoning, abdominal pain, diarrhea, inflammation, skin itch and the like, and the curative effect is remarkable. Nowadays, researchers have proved that antrodia camphorata has various effects of relieving alcoholism, protecting liver, resisting tumor, cancer, virus, inflammation, oxidation, fatigue, regulating immunity and the like, and hundreds of active substances are separated from antrodia camphorata, wherein the antrodia camphorata triterpene substances have obvious alcoholism relieving effect and anti-hepatic fibrosis activity and comprise polysaccharides, diterpenoids, triterpenoids, steroids, benzene ring derivatives and the like. At present, the medicinal value of the antrodia camphorata is even higher than that of traditional medicinal materials such as ganoderma lucidum, ginseng, cordyceps sinensis and the like, and the antrodia camphorata is a famous and genuine medicine of the antrodia camphorata.
Researches show that the main active substances of the antrodia camphorata for relieving alcoholism and protecting liver are terpenoids, and particularly, the triterpenoids are the most prominent. However, the highest triterpene content in the antrodia camphorata is the wild antrodia camphorata fruiting body or the basswood cultivated fruiting body, the next highest triterpene content is the solid antrodia camphorata fruiting body or mycelium, and the triterpene content in the liquid antrodia camphorata fermentation mycelium is lower. In addition, terpenoids are generally alcohol-soluble substances, which are poorly soluble in water. Therefore, the alcohol extract of the antrodia camphorata has higher content of triterpenes, and the water extract contains almost no terpenoids. In the existing antrodia camphorata antialcoholic formula, the raw materials of antrodia camphorata are mostly not specified, the liquid fermentation mycelium or the water extract of the antrodia camphorata raw materials are specified, and the antrodia camphorata antialcoholic effect cannot be fully exerted by the formula.
Disclosure of Invention
The purpose of the invention is as follows: aiming at the defects in the prior art, the invention provides antrodia camphorata antialcoholic pill which comprises a natural composition with antialcoholic and hepatoprotective functions, can effectively antialcoholize and prevent drunkenness, and also has the effects of resisting fatigue, inflammation, oxidation, fatigue, blood fat, immunity and the like. The alcohol extract of the antrodia camphorata (fruiting body) is taken as a main component, and other sobering-up or seasoning substances are added, so that the sobering-up and liver-protecting effects of the antrodia camphorata are exerted to the maximum extent.
The invention also provides a preparation method of the antrodia camphorata anti-alcoholism pill.
The technical scheme is as follows: in order to achieve the purpose, the antrodia camphorata anti-alcoholism pill is mainly prepared from the following raw materials in parts by weight: 40-60 parts of antrodia camphorata alcohol extract, 7-11 parts of hovenia dulcis thunb, 5-8 parts of kudzu root, 1-3 parts of vitamin, 1-3 parts of amino acid, 6-10 parts of stabilizer, 5-10 parts of sweetener and 2-5 parts of flavoring agent.
The antrodia camphorata alcohol extract is an antrodia camphorata fruiting body cultured by wild, basswood or solid state, or an ethanol extract of antrodia camphorata mycelium fermented in solid state or liquid state, and the mycelium is obtained after fermentation is finished.
Wherein the sweetener is honey and sucrose.
Wherein, the stabilizer is xanthan gum.
Wherein the amino acids are alanine and leucine.
Wherein the vitamins are vitamin B1, vitamin B6 and vitamin C.
Wherein the correctant is Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis.
The preparation method of the antrodia camphorate anti-alcoholism pill comprises the following steps:
(1) weighing Antrodia Camphorata fruiting body or Antrodia Camphorata mycelium, adding anhydrous ethanol, reflux extracting, filtering to obtain filtrate, repeatedly extracting, and mixing filtrates to obtain Antrodia Camphorata ethanol extractive solution;
(2) evaporating ethanol in the Antrodia camphorata ethanol extract to dryness, and then performing microwave vacuum drying and crushing to obtain Antrodia camphorata ethanol extract powder (namely the Antrodia camphorata ethanol extract in the components);
(3) slicing radix Puerariae and correctant (Glycyrrhrizae radix, Bulbus Lilii, and rhizoma Phragmitis), and mashing semen Hoveniae;
(4) mixing mashed semen Hoveniae, sliced radix Puerariae and correctant, adding clear water, boiling, filtering, collecting filtrate, centrifuging, collecting supernatant, and vacuum freeze drying to obtain water extract powder;
(5) and (3) uniformly mixing the antrodia camphorata alcohol extract powder in the step (2) and the water extract powder in the step (4) with amino acid, vitamin, sweetening agent and stabilizing agent according to a proportion, and preparing the mixture into pills with the size similar to that of soybeans.
Adding the antrodia camphorata fruiting bodies or antrodia camphorata mycelia in the step (1) into ethanol according to the mass ratio of 1: 1-1: 50, performing reflux extraction for 1-6 hours in a water bath at 50-90 ℃, filtering to obtain filtrate, repeatedly extracting for two times, and combining the filtrate to obtain the antrodia camphorata alcohol extract.
Wherein, the clean water is added in the step (4) to boil for 10-60 min, the gauze is used for filtering and collecting the filtrate, and the filtrate is centrifuged for 5-60 min at 4000-10000 r/min.
The main effective component of the antrodia camphorata alcohol-relieving pill is antrodia camphorata alcohol extract, has obvious effects of relieving alcoholism and protecting liver, and also has the effects of resisting fatigue, resisting inflammation, resisting oxidation, resisting fatigue, reducing blood fat, regulating immunity and the like; the addition of a proper amount of vitamin B1 can make up the deficiency of vitamin B1 in the production of human ketocheese after ethanol enters the human body, thereby damaging cells; vitamin B6 also plays a certain role in the process of resisting alcohol in the body, and can participate in the metabolism of fat and amino acid as a prosthetic group of various enzymes; vitamin C is an important antioxidant, can effectively reduce the damage to the organism in the alcohol metabolism process, and can be synergistically acted with the kudzuvine root in the aspects of dispelling the effects of alcohol and protecting the liver to achieve the effects of dispelling the effects of alcohol acutely and preventing drunkenness and protecting the liver chronically.
The vitamin B1 added in the invention is one of the main substances for promoting alcohol metabolism, can accelerate the decomposition of acetaldehyde in alcohol, and can reduce the burden of heart and liver; vitamin B6 has effects of promoting metabolism and enhancing hangover alleviating speed, and can be used as coenzyme of various enzymes to participate in metabolism of various amino acids, promote absorption of amino acids and synthesis of protein; vitamin C can help to maintain normal alcohol metabolism, supplement of vitamin C before drinking can help to accelerate alcohol metabolism and protect liver, relieve drunkenness, and promote vitamin B1 absorption. The protein amino acids such as alanine and leucine are internal factors of the sobering-up peptide product for sobering up and protecting liver, the antrodia camphorata sobering-up pill prepared by the invention contains the amino acids, can improve the concentration of blood amino acids and accelerate metabolism, and the amino acids can activate the key enzyme ADH of alcohol metabolism3(alcohol dehydrogenase) to further promote the metabolism of alcohol, thereby achieving the effect of sobering up. The active substance in the alcohol extract of Antrodia camphorata can be extracted by enhancing the content of BThe activity of alcohol metabolism related enzyme can promote the metabolism of alcohol in vivo, and has the effect of resisting hepatic fibrosis, and can prevent acute alcoholic liver injury, and radix Puerariae and semen Hoveniae also have good hangover alleviating effect. However, the alcohol extract of antrodia camphorata is extremely bitter in taste, has a certain stimulation effect on intestines and stomach, and easily causes diarrhea when being excessively ingested. The content of the antrodia camphorata alcohol extract in the formula is higher, so that the bitter taste of the antrodia camphorata alcohol extract is covered by adding sucrose and honey; the stimulation of the antrodia camphorata alcohol extract to intestines and stomach is relieved by adding various vitamins, amino acids and other nutrient substances. Meanwhile, substances such as amino acid, vitamin and the like and the antrodia camphorata alcohol extract play a synergistic and additive effect through different or similar action mechanisms, so that the sobering-up effect of the invention is better.
Has the advantages that: compared with the prior art, the invention has the following advantages:
the main effective component of the antrodia camphorata alcohol effect dispelling pill is antrodia camphorata alcohol extract, and hovenia dulcis thunb, radix puerariae, amino acid, vitamin and other substances with the effect of dispelling the effects of alcohol are supplemented, so that the effect of dispelling the effects of alcohol is further improved, and the antrodia camphorata alcohol effect dispelling pill can play a remarkable effect of dispelling the effects of alcohol and preventing drunkenness through the synergistic effect of all the components. By adding substances such as sweetening agents, flavoring agents and the like, the bitter taste of the antrodia camphorata sobering-up pill is fully covered, and the taste of the antrodia camphorata sobering-up pill is obviously improved. The components in the formula are safe, have no side effect, can accelerate the decomposition and excretion of alcohol in vivo, and simultaneously have good effects of protecting liver, spleen, stomach and other organs. Meanwhile, compared with the single extracts of the antrodia camphorata, the hovenia dulcis thunb and the kudzuvine root under the same dosage, the extract has better effect of improving the symptoms of alcoholic liver injury. In addition, the active ingredients in the antrodia camphorata alcohol extract also have the effects of resisting fatigue, inflammation, oxidation, fatigue, blood fat and immunity, and the like, can be used for daily conditioning, and has good market prospect.
The preparation method is simple and convenient, is easy to carry out industrial production, has stable product quality, and meets the modern food supervision requirement.
Detailed Description
The present invention is further illustrated by the following examples.
Example 1
The antrodia camphorata antialcoholic pill comprises the following components in parts by weight:
60 parts of antrodia camphorata alcohol extract, 10 parts of hovenia dulcis thunb, 7 parts of kudzu root, 1 part of alanine, 1 part of leucine, 1 parts of vitamin C, 10.5 parts of vitamin B, 60.5 parts of vitamin B, 8 parts of xanthan gum, 5 parts of sucrose, 4 parts of honey, 1 part of liquorice, 0.7 part of lily and 0.3 part of reed rhizome.
The preparation method comprises the following steps:
(1) weighing liquid fermentation mycelium of antrodia camphorata, adding absolute ethyl alcohol according to the mass ratio of 1:10, carrying out reflux extraction for 3h in a water bath at 70 ℃, filtering to obtain filtrate, repeatedly extracting twice, and combining the filtrate to obtain antrodia camphorata alcohol extract.
(2) Evaporating ethanol in the Antrodia camphorata ethanol extract to dryness, and then performing microwave vacuum drying and crushing to obtain Antrodia camphorata ethanol extract powder, namely the Antrodia camphorata ethanol extract.
(3) Slicing radix Puerariae, Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis, and mashing semen Hoveniae;
(4) mixing mashed semen Hoveniae with sliced radix Puerariae, Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis uniformly, adding clear water at a mass ratio of 1:10(w/w), boiling for 30min, filtering with gauze, collecting filtrate, centrifuging filtrate 6000r/min for 30min, collecting supernatant, and vacuum freeze drying to obtain water extract powder.
(5) And (3) uniformly mixing the antrodia camphorata ethanol extract powder in the step (2) and the water extract powder in the step (4) with alanine, leucine, vitamin B1, vitamin B6, vitamin C, honey, sucrose and xanthan gum, and preparing the mixture into pills with the size similar to that of soybeans.
Example 2
The antrodia camphorata antialcoholic pill comprises the following components in parts by weight:
60 parts of linden-cultivated antrodia cinnamomea fruiting body alcohol extract, 10 parts of hovenia dulcis thunb, 7 parts of kudzu root, 1 part of alanine, 1 part of leucine, 1 parts of vitamin C, 10.5 parts of vitamin B, 60.5 parts of vitamin B, 8 parts of xanthan gum, 5 parts of sucrose, 4 parts of honey, 1 part of licorice, 0.7 part of lily and 0.3 part of reed rhizome.
The preparation method is the same as example 2, except that: replacing liquid fermentation mycelium with basswood cultured Antrodia camphorata fruiting body.
Comparative example 1
The antrodia camphorata antialcoholic pill comprises the following components in parts by weight:
60 parts of antrodia camphorata mycelium aqueous extract, 10 parts of hovenia dulcis thunb, 7 parts of kudzu root, 1 part of alanine, 1 part of leucine, 1 parts of vitamin C, 10.5 parts of vitamin B, 60.5 parts of vitamin B, 8 parts of xanthan gum, 5 parts of sucrose, 4 parts of honey, 1 part of liquorice, 0.7 part of lily and 0.3 part of reed rhizome.
The preparation method comprises the following steps:
(1) weighing liquid fermentation mycelium of antrodia camphorata, adding clear water according to the mass ratio of 1:10, leaching in water bath at 98 ℃ for 3h, centrifuging at 6000r/min for 30min, taking supernatant, repeatedly extracting twice and combining the supernatant to obtain the antrodia camphorata water extract.
(2) Vacuum freeze drying and pulverizing the water extractive solution of Antrodia camphorata to obtain water extractive powder of Antrodia camphorata.
(3) Slicing radix Puerariae, Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis, and mashing semen Hoveniae;
(4) mixing mashed semen Hoveniae with sliced radix Puerariae, Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis uniformly, adding clear water at a mass ratio of 1:10(w/w), boiling for 30min, filtering with gauze, collecting filtrate, centrifuging filtrate 6000r/min for 30min, collecting supernatant, and vacuum freeze drying to obtain water extract powder.
(5) And (3) uniformly mixing the antrodia camphorata water extract powder in the step (2) and the water extract powder in the step (4) with alanine, leucine, vitamin B1, vitamin B6, vitamin C, honey, sucrose and xanthan gum, and preparing the mixture into pills with the size similar to that of soybeans.
Comparative example 2
The antrodia camphorata antialcoholic pill comprises the following components in parts by weight:
60 parts of basswood-cultivated antrodia camphorata fruiting body powder, 10 parts of hovenia dulcis thunb, 7 parts of kudzu root, 1 part of alanine, 1 part of leucine, 1 parts of vitamin C, 10.5 parts of vitamin B, 60.5 parts of vitamin B, 8 parts of xanthan gum, 5 parts of sucrose, 4 parts of honey, 1 part of liquorice, 0.7 part of lily and 0.3 part of reed rhizome.
The preparation method comprises the following steps:
(1) sun drying or oven drying at 75 deg.C and pulverizing to obtain fruiting body powder;
(2) slicing radix Puerariae, Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis, and mashing semen Hoveniae;
(3) mixing mashed semen Hoveniae with sliced radix Puerariae, Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis uniformly, adding clear water at a mass ratio of 1:10(w/w), boiling for 30min, filtering with gauze, collecting filtrate, centrifuging filtrate 6000r/min for 30min, collecting supernatant, and vacuum freeze drying to obtain water extract powder.
(4) Uniformly mixing the antrodia camphorata sporocarp powder in the step (1) and the water extract powder in the step (3) with alanine, leucine, vitamin B1, vitamin B6, vitamin C, honey, sucrose and xanthan gum, and preparing the mixture into pills with the size similar to that of soybeans.
Comparative example 3
The antrodia camphorata antialcoholic pill comprises the following components in parts by weight:
60 parts of linden-cultivated antrodia cinnamomea fruiting body alcohol extract, 8 parts of xanthan gum, 5 parts of sucrose, 4 parts of honey, 1 part of liquorice, 0.7 part of lily and 0.3 part of reed rhizome.
The preparation method comprises the following steps:
(1) weighing basswood cultured antrodia camphorata fruiting body, adding absolute ethyl alcohol according to the mass ratio of 1:10, carrying out reflux extraction for 3h in a water bath at 70 ℃, filtering to obtain filtrate, repeatedly extracting twice, and combining the filtrates to obtain antrodia camphorata ethanol extract.
(2) Evaporating ethanol in the Antrodia camphorata ethanol extract to dryness, and then performing microwave vacuum drying and crushing to obtain Antrodia camphorata ethanol extract powder.
(3) Cutting Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis into pieces, mixing, adding clear water at a mass ratio of 1:10(w/w), boiling for 30min, filtering with gauze, collecting filtrate, centrifuging for 30min at 6000r/min, collecting supernatant, and vacuum freeze drying to obtain water extract powder.
(4) And (3) uniformly mixing the antrodia camphorata alcohol extract powder in the step (2) and the water extract powder in the step (3) with honey, cane sugar and xanthan gum, and preparing the mixture into pills with the size similar to that of soybeans.
Test examples
In order to further show the performance of the antrodia camphorata anti-alcoholism pill provided by the invention, the antrodia camphorata anti-alcoholism pills in the examples 1 and 2 and the comparative examples 1 and 2 and 3 are taken as examples, and the test methods, the test data and the related analysis are as follows:
first, sober-up drug effect test
1. The test method comprises the following steps:
grinding the antrodia camphorate pills for relieving alcoholism, weighing 2g of the antrodia camphorate pills, adding the ground antrodia camphorate pills into 10mL of drinking water, and uniformly mixing for later use. And then taking 60 ICR mice (half each male and female) of 8 weeks old, randomly dividing the ICR mice into 6 groups, randomly dividing each group into 10 mice, and perfusing the mice with the Chinese liquor (red star Erguotou with the alcoholic strength of 56 degrees) according to the weight proportion of the mice, wherein the dosage is 0.15mL/10g (namely, perfusing the mice with the Chinese liquor of 0.15mL per 10g of the weight), and after the mice lose consciousness and the righting reflex disappears (drunk), treating each group as follows:
group 1: the drinking water is used in an amount of 0.68mL/10g according to the weight proportion of the mouse (namely, the drinking water is used in an amount of 0.68mL per 10g of the weight of the mouse);
group 2: the formula of the antrodia camphorata anti-alcoholism pill in the embodiment 1 provided by the invention is used for intragastric administration according to the weight proportion of the mice, and the dosage is 0.68mL/10g (namely, 0.68mL of pill mixing liquid is used for intragastric administration according to the weight of each 10g of the mice);
group 3: the formula of the antrodia camphorata anti-alcoholism pill in the embodiment 2 provided by the invention is used in an amount of 0.68mL/10g according to the weight proportion of the mouse (namely, the pill mixing solution is mixed according to the weight of the mouse per 10g of weight and 0.68mL of intragastric administration);
group 4: the formula of the antrodia camphorata anti-alcoholism pill in the comparative example 1 provided by the invention is used for intragastric administration according to the weight proportion of the mice, and the dosage is 0.68mL/10g (namely, 0.68mL of pill mixing liquid is intragastric administered according to the weight of each 10g of the mice);
group 5: the formula of the antrodia camphorata anti-alcoholism pill in the comparative example 2 provided by the invention is used for intragastric administration according to the weight proportion of the mice, and the dosage is 0.68mL/10g (namely, 0.68mL of pill mixing liquid is intragastric administered according to the weight of each 10g of the mice);
group 6: the formula of the antrodia camphorata anti-alcoholism pill in the comparative example 3 provided by the invention is used in an amount of 0.68mL/10g according to the weight proportion of the mouse (namely, the formula is prepared by mixing the pill with 0.68mL for each 10g of the mouse by intragastric administration).
The time required for mice to switch from disappearance of the reflex (intoxicated) to recovery of the righting reflex (sobered) was recorded after the above treatment.
2. Test results and analysis
The results of the sobering-up efficacy test are shown in table 1:
TABLE 1 sobering-up drug effect test results
Note: indicates that the control phase 1 of the group data had significant differences at the 0.05 level.
As can be seen from Table 1: (1) the mice in group 3 had the shortest average time to sober up, indicating that group 3 had the best anti-hangover effect. Because the main component of the pill formula used in the group 3 is the alcohol extract of the basswood cultivated antrodia camphorata fruiting body, the content of the antrodia camphorata triterpene is most abundant, and the pill formula has better synergistic effect with the components with the effect of relieving alcoholism, such as hovenia dulcis thunb, radix puerariae, amino acid, vitamin and the like in the formula, so the effect of relieving alcoholism is optimal; (2) the next time to sober was the mice in group 2. The pill formula used in the group 2 mainly becomes liquid fermented antrodia camphorata mycelium alcohol extract which also contains higher content of antrodia camphorata triterpenes, thus showing better sobering effect. However, the terpenoids in the antrodia camphorata mycelium are not abundant in the antrodia camphorata fruiting body, and the proportion of each triterpenoid is different, so the alcohol effect of the antrodia camphorata mycelium alcohol extract is not as good as that of the antrodia camphorata fruiting body alcohol extract; (3) the third shortest time to sober was the mice in group 6. The main component of the pill formula used in group 6 is an alcohol extract of the fruiting body of linden wood-cultivated antrodia camphorata, but other substances with the effect of relieving alcoholism, such as hovenia dulcis thunb, radix puerariae, amino acid, vitamins and the like, are not added, but the formula still shows good effect of relieving alcoholism. The alcohol extract of the antrodia camphorata is proved to be the main active substance for relieving alcoholism in the invention. The effect of the group 6 is obviously inferior to that of the group 3, so that the effect of relieving alcoholism of the antrodia camphorata alcohol extract is remarkably improved by adding other substances with the effect of relieving alcoholism, such as hovenia dulcis thunb, radix puerariae, amino acid, vitamins and the like, and each component has a good synergistic interaction effect; (4) the mice in group 5 took relatively long time to sober up, and the pill formulation used in group 5 also showed good sobering up efficacy because the main ingredient of the pill formulation used in group 5 was basswood-cultivated antrodia camphorata fruiting body powder, which also contained a certain amount of antrodia camphorata terpenoids and other active substances. The effect is far inferior to that of the groups 2, 3 and 6, which shows that the effect of directly using the antrodia camphorata sporocarp or mycelium powder for relieving alcoholism is obviously lower than that of the antrodia camphorata alcohol extract; (5) the mice in group 4 were the longest in the time to sober up. Because the main component of the pill formula used in group 4 is the liquid fermented aqueous extract of antrodia camphorata mycelia, the aqueous extract contains almost no antrodia camphorata terpenoids but contains abundant antrodia camphorata polysaccharides. The group has poor antialcoholic effect, which indicates that the main antialcoholic active substances of the antrodia camphorata are not in the water extract. However, the formula still shows a certain effect of relieving alcoholism because the hovenia dulcis thunb, the radix puerariae, the amino acid, the vitamin and other substances in the formula also have the effect of relieving alcoholism.
Second, anti-intoxication drug effect experiment
1. Test method
Grinding the antrodia camphorate pills for relieving alcoholism, weighing 2g of the antrodia camphorate pills, adding the ground antrodia camphorate pills into 10mL of drinking water, and uniformly mixing for later use. 60 ICR mice (female and male half) with the age of 8 weeks are taken and randomly divided into 6 groups of 10 mice, and after the mice freely take water for 12 hours, the groups are treated as follows:
group 1: the drinking water is used in an amount of 0.68mL/10g according to the weight proportion of the mouse (namely, the drinking water is used in an amount of 0.68mL per 10g of the weight of the mouse);
group 2: the formula of the antrodia camphorata anti-alcoholism pill in the embodiment 1 provided by the invention is used for intragastric administration according to the weight proportion of the mice, and the dosage is 0.68mL/10g (namely, 0.68mL of pill mixing liquid is used for intragastric administration according to the weight of each 10g of the mice);
group 3: the formula of the antrodia camphorata anti-alcoholism pill in the embodiment 2 provided by the invention is used in an amount of 0.68mL/10g according to the weight proportion of the mouse (namely, the pill mixing solution is mixed according to the weight of the mouse per 10g of weight and 0.68mL of intragastric administration);
group 4: the formula of the antrodia camphorata anti-alcoholism pill in the comparative example 1 provided by the invention is used for intragastric administration according to the weight proportion of the mice, and the dosage is 0.68mL/10g (namely, 0.68mL of pill mixing liquid is intragastric administered according to the weight of each 10g of the mice);
group 5: the formula of the antrodia camphorata anti-alcoholism pill in the comparative example 2 provided by the invention is used for intragastric administration according to the weight proportion of the mice, and the dosage is 0.68mL/10g (namely, 0.68mL of pill mixing liquid is intragastric administered according to the weight of each 10g of the mice);
group 6: the formula of the antrodia camphorata anti-alcoholism pill in the comparative example 3 provided by the invention is used in an amount of 0.68mL/10g according to the weight proportion of the mouse (namely, the formula is prepared by mixing the pill with 0.68mL for each 10g of the mouse by intragastric administration).
After the treatment, the mice in the 6 groups were respectively gazed with the liquor (alcohol content is 56 degrees, red star and two-pot spirit) according to the weight proportion of the mice, the dosage is 0.3mL/10g (namely, the liquor is gazed with 0.3mL per 10g of the weight of the mice), and the time from the end of gazing to the loss of consciousness of the mice is recorded.
2. Test results and analysis
The anti-intoxication drug efficacy test results are shown in table 2:
TABLE 2 anti-intoxication drug efficacy test results
Note: indicates that the control phase 1 of the group data had significant differences at the 0.05 level.
As can be seen from Table 2: (1) the mice in group 3 had the longest mean anti-intoxication time, indicating that group 3 had the best anti-intoxication effect. Because the main component of the pill formula used in the group 3 is the alcohol extract of the basswood cultivated antrodia camphorata fruiting body, the content of the antrodia camphorata triterpene is most abundant, and the pill formula has better synergistic effect with the components with the effect of relieving alcoholism, such as hovenia dulcis thunb, radix puerariae, amino acid, vitamin and the like in the formula, so the anti-intoxication effect is optimal; (2) the next longest time to prevent intoxication was the mice in group 2. The formula of the pill used in the group 2 mainly becomes the liquid fermented antrodia camphorata mycelium alcohol extract which also contains higher content of antrodia camphorata triterpenes, thus showing better anti-intoxication effect. However, the terpenoids in the antrodia camphorata mycelium are not abundant in the antrodia camphorata fruiting body, and the proportion of each triterpenoid is different, so the anti-intoxication effect of the antrodia camphorata mycelium alcohol extract is not as good as that of the antrodia camphorata fruiting body alcohol extract; (3) the third longest time to be sobered was the mice in group 6. The main component of the pill formula used in group 6 is an alcohol extract of the fruiting body of antrodia camphorata cultivated in basswood, but other substances with the effect of relieving alcoholism, such as hovenia dulcis thunb, radix puerariae, amino acid, vitamins and the like, are not added, but the formula still shows good anti-intoxication effect. The alcohol extract of the antrodia camphorata is proved to be the main active substance for relieving alcoholism and preventing drunkenness in the invention. The effect of the group 6 is obviously inferior to that of the group 3, so that the effect of relieving alcoholism and preventing drunkenness of the antrodia camphorata alcohol extract is remarkably improved by adding other substances with the effects of relieving alcoholism, such as hovenia dulcis thunb, radix puerariae, amino acid, vitamins and the like, and the components have good synergistic effect; (4) the anti-intoxication time of the mice in group 5 was relatively short, and the pill formulation used in group 5 was a basswood-cultivated antrodia camphorata fruit body powder which also contained a certain amount of antrodia camphorata terpenoids and other active substances, thus also showing a good anti-intoxication efficacy. The effect is far inferior to that of the groups 2, 3 and 6, which shows that the effect of relieving alcoholism and preventing drunkenness by directly using the antrodia camphorata sporocarp or mycelium powder is obviously lower than that of the antrodia camphorata alcohol extract; (5) the mice in group 4 were the least intoxicated. Because the main component of the pill formula used in group 4 is the liquid fermented aqueous extract of antrodia camphorata mycelia, the aqueous extract contains almost no antrodia camphorata terpenoids but contains abundant antrodia camphorata polysaccharides. The group had poor anti-intoxication effect, indicating that the main anti-hangover and anti-intoxication active substances of Antrodia camphorata were not in the aqueous extract. However, the formula still shows a certain effect of relieving alcoholism because the hovenia dulcis thunb, the radix puerariae, the amino acid, the vitamin and other substances in the formula also have the effect of relieving alcoholism.
Liver-protecting and stomach-nourishing efficacy test
1. Test method
Grinding the antrodia camphorate pills for relieving alcoholism, weighing 2g of the antrodia camphorate pills, adding the ground antrodia camphorate pills into 10mL of drinking water, and uniformly mixing for later use. 60 ICR mice (female and male half) with the age of 8 weeks are taken and randomly divided into 6 groups of 10 mice, and after the mice freely take water for 12 hours, the groups are treated as follows:
group 1: the drinking water is infused according to the weight proportion of the mouse, the dosage is 0.23mL/10g (namely, the drinking water is infused according to the weight of the mouse per 10 g), after 30min, the Hongxing Erguotou wine with the alcoholic strength of 56 degrees is infused to the mouse according to the weight proportion of the mouse, and the dosage is 0.12mL/10 g;
group 2: gavage is performed according to the weight proportion of the mice, the dosage of the antrodia camphorata anti-alcoholism pill formula in the embodiment 1 provided by the invention is 0.23mL/10g (namely, the pill mixing solution is 0.23mL for each 10g of weight of the mice), and after 30min, the Hongxing Erguotou wine with the alcoholic strength of 56 degrees is infused into the mice according to the weight proportion of the mice, and the dosage is 0.12mL/10g (namely, the Erguotou wine is 0.12mL for each 10g of weight of the mice);
group 3: gavage is performed according to the weight proportion of the mice, the dosage of the antrodia camphorata anti-alcoholism pill formula in the embodiment 2 is 0.23mL/10g (namely, the pill mixing solution is 0.23mL for each 10g of weight of the mice), and after 30min, the Hongxing Erguotou wine with the alcoholic strength of 56 degrees is infused into the mice according to the weight proportion of the mice, and the dosage is 0.12mL/10g (namely, the Erguotou wine is 0.12mL for each 10g of weight of the mice);
group 4: the formula of the antrodia camphorate anti-alcoholism pill in the comparative example 1 provided by the invention is filled according to the weight proportion of the mouse, the dosage is 0.23mL/10g (namely, the pill mixing solution is filled according to the weight of the mouse per 10 g), and after 30min, the Hongxing Erguotou wine with the alcoholic strength of 56 degrees is filled into the mouse according to the weight proportion of the mouse, and the dosage is 0.12mL/10g (namely, the Erguotou wine is filled according to the weight of the mouse per 10 g);
group 5: the formula of the antrodia camphorate anti-alcoholism pill in the comparative example 2 provided by the invention is filled according to the weight proportion of the mouse, the dosage is 0.23mL/10g (namely, the pill mixing solution is filled according to the weight of the mouse per 10g of the weight of the antrodia camphorate anti-alcoholism pill), and after 30min, the Hongxing Erguotou wine with the alcoholic strength of 56 degrees is filled into the mouse according to the weight proportion of the mouse, and the dosage is 0.12mL/10g (namely, the Erguotou wine is filled according to the weight of the mouse per 10g of the weight of the stomach);
group 6: the formula of the antrodia camphorata anti-alcoholism pill in the comparative example 3 provided by the invention is filled according to the weight proportion of the mouse, the dosage is 0.23mL/10g (namely, the pill mixing solution is filled according to the weight of the mouse per 10 g), and after 30min, the Hongxing Erguotou wine with the alcoholic strength of 56 degrees is filled into the mouse according to the weight proportion of the mouse, and the dosage is 0.12mL/10g (namely, the Erguotou wine is filled according to the weight of the mouse per 10 g).
Blood was taken from the eyeball 7 days after the same operation, the liver and stomach were immediately taken out, and the serum alcohol concentration and the Alcohol Dehydrogenase (ADH) activity of the liver and stomach tissues were measured by biochemical colorimetry, respectively.
2. Test results and analysis
The liver-protecting and stomach-nourishing efficacy test results are shown in table 3:
TABLE 3 liver-protecting and stomach-nourishing drug effect test results
Note: indicates that the control phase 1 of the group data had significant differences at the 0.05 level.
As can be seen from Table 3:
(1) the mice in group 3 had the lowest average serum alcohol content and the highest ADH activity in the liver and stomach, indicating that group 3 had the best liver-protecting and stomach-nourishing effect. Because the main component of the pill formula in the group 3 is the alcohol extract of the basswood cultivated antrodia camphorata fruiting body, the antrodia camphorata triterpene content is most abundant, and the antrodia camphorata triterpene content and the components of hovenia dulcis thunb, radix puerariae, amino acid, vitamin and the like in the formula play a better synergistic effect, so that the high-efficiency and timely degradation of alcohol in a mouse body can be promoted, and the optimal liver-protecting and stomach-nourishing effect is shown; (2) the second to protect liver and stomach effects were mice in group 2. The formula of the pill used in the group 2 mainly becomes the liquid fermented antrodia camphorata mycelium alcohol extract which also contains higher content of antrodia camphorata triterpenes and can effectively promote the alcohol degradation in mice, thus showing better liver-protecting and stomach-nourishing effects. However, the terpenoids in the antrodia camphorata mycelium are not as abundant as the antrodia camphorata fruiting body, and the proportion of each triterpenoid is different, so the liver-protecting and stomach-nourishing effect of the antrodia camphorata mycelium alcohol extract is not as good as that of the antrodia camphorata fruiting body alcohol extract; (3) liver-protecting and stomach-nourishing effects the mice in group 6 were the third best. The main component of the pill formula used in group 6 is an alcohol extract of the fruiting body of linden wood-cultivated antrodia camphorata, but other substances with the effect of relieving alcoholism, such as hovenia dulcis thunb, radix puerariae, amino acid, vitamins and the like, are not added, but the formula still shows good effect of relieving alcoholism. The antrodia camphorata alcohol extract is proved to be the main active substance for relieving alcoholism, protecting liver and nourishing stomach in the invention. However, the effect of the group 6 is obviously inferior to that of the group 3, which proves that the liver-protecting and stomach-nourishing efficacy of the antrodia camphorata alcohol extract is remarkably improved by adding the hovenia dulcis thunb, the kudzuvine root and the amino acid, especially the vitamins and other substances, and the components have good synergistic effect; (4) the mice in group 5 had higher serum alcohol content and relatively lower liver and stomach ADH activity. The pill formula used in group 5 mainly contains basswood-cultivated antrodia camphorata fruiting body powder, and the powder also contains a certain amount of antrodia camphorata terpenoids and other active substances, so that the pill formula also shows better liver-protecting and stomach-nourishing effects. However, the effect is far inferior to that of the groups 2, 3 and 6, which shows that the liver-protecting and stomach-nourishing effect of directly using the antrodia camphorata sporophore or mycelium powder is obviously lower than that of the antrodia camphorata alcohol extract; (5) mice in group 4 had the highest serum alcohol content and the lowest ADH activity in liver and stomach. Because the main component of the pill formula used in group 4 is the liquid fermented aqueous extract of antrodia camphorata mycelia, the aqueous extract contains almost no antrodia camphorata terpenoids but contains abundant antrodia camphorata polysaccharides. The group has poor effect of nourishing liver and protecting stomach, which indicates that the main active substances of antrodia camphorata for relieving alcoholism and protecting liver are not in the water extract. However, the formula still shows a certain effect of relieving alcoholism because the hovenia dulcis thunb, the radix puerariae, the amino acid, the vitamin and other substances in the formula also have certain effects of relieving alcoholism, nourishing the liver and protecting the stomach.
Example 3
The antrodia camphorata antialcoholic pill comprises the following components in parts by weight:
40 parts of antrodia camphorata alcohol extract, 7 parts of hovenia dulcis thunb, 5 parts of kudzu root, 0.5 part of alanine, 0.5 part of leucine, 0.6 part of vitamin C, 10.2 parts of vitamin B, 60.2 parts of vitamin B, 6 parts of xanthan gum, 2.5 parts of sucrose, 2.5 parts of honey, 1 part of liquorice, 0.5 part of lily and 0.5 part of reed rhizome.
The preparation method comprises the following steps:
(1) weighing solid fermentation mycelium of antrodia camphorata, adding absolute ethyl alcohol according to the mass ratio of 1:1, carrying out reflux extraction for 1h in a water bath at 50 ℃, filtering to obtain filtrate, repeatedly extracting twice, and combining the filtrate to obtain antrodia camphorata alcohol extract.
(2) Evaporating ethanol in the Antrodia camphorata ethanol extract to dryness, and then performing microwave vacuum drying and crushing to obtain Antrodia camphorata ethanol extract powder, namely the Antrodia camphorata ethanol extract.
(3) Slicing radix Puerariae, Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis, and mashing semen Hoveniae;
(4) mixing mashed semen Hoveniae with sliced radix Puerariae, Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis uniformly, adding clear water at a mass ratio of 1:10(w/w), boiling for 10min, filtering with gauze, collecting filtrate, centrifuging filtrate at 4000r/min for 60min, collecting supernatant, and vacuum freeze drying to obtain water extract powder.
(5) And (3) uniformly mixing the antrodia camphorata ethanol extract powder in the step (2) and the water extract powder in the step (4) with alanine, leucine, vitamin B1, vitamin B6, vitamin C, honey, sucrose and xanthan gum, and preparing the mixture into pills with the size similar to that of soybeans.
Example 4
The antrodia camphorata antialcoholic pill comprises the following components in parts by weight:
60 parts of antrodia camphorata alcohol extract, 11 parts of hovenia dulcis thunb, 8 parts of kudzu root, 1.5 parts of alanine, 1.5 parts of leucine, 1 parts of vitamin C, 11 parts of vitamin B, 61 parts of vitamin B, 10 parts of xanthan gum, 5 parts of sucrose, 5 parts of honey, 2 parts of liquorice, 2 parts of lily and 1 part of reed rhizome.
The preparation method comprises the following steps:
(1) weighing wild Antrodia camphorata fruiting body, adding absolute ethyl alcohol according to the mass ratio of 1:50, carrying out reflux extraction for 6 hours in a water bath at 90 ℃, filtering to obtain filtrate, repeatedly extracting twice, and combining the filtrate to obtain the Antrodia camphorata alcohol extract.
(2) Evaporating ethanol in the Antrodia camphorata ethanol extract to dryness, and then performing microwave vacuum drying and crushing to obtain Antrodia camphorata ethanol extract powder, namely the Antrodia camphorata ethanol extract.
(3) Slicing radix Puerariae, Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis, and mashing semen Hoveniae;
(4) mixing mashed semen Hoveniae with sliced radix Puerariae, Glycyrrhrizae radix, Bulbus Lilii and rhizoma Phragmitis uniformly, adding clear water at a mass ratio of 1:10(w/w), boiling for 60min, filtering with gauze, collecting filtrate, centrifuging filtrate at 10000r/min for 5min, collecting supernatant, and vacuum freeze drying to obtain water extract powder.
(5) And (3) uniformly mixing the antrodia camphorata ethanol extract powder in the step (2) and the water extract powder in the step (4) with alanine, leucine, vitamin B1, vitamin B6, vitamin C, honey, sucrose and xanthan gum, and preparing the mixture into pills with the size similar to that of soybeans.
Claims (10)
1. An antrodia camphorate pill for alleviating hangover is characterized by being mainly prepared from the following raw materials in parts by weight: 40-60 parts of antrodia camphorata alcohol extract, 7-11 parts of hovenia dulcis thunb, 5-8 parts of kudzu root, 1-3 parts of vitamin, 1-3 parts of amino acid, 6-10 parts of stabilizer, 5-10 parts of sweetener and 2-5 parts of flavoring agent.
2. The antrodia camphorata hangover alleviating pill according to claim 1, wherein the antrodia camphorata alcohol extract is an ethanol extract of wild, basswood-cultivated or solid-cultured antrodia camphorata fruit bodies, or an ethanol extract of solid-fermented or liquid-fermented antrodia camphorata mycelia.
3. The antrodia camphorata hangover alleviating pill according to claim 1, wherein the sweeteners are honey and sucrose.
4. The antrodia camphorata hangover alleviating pill according to claim 1, wherein the stabilizer is xanthan gum.
5. The antrodia camphorata hangover alleviating pill according to claim 1, wherein the amino acids are alanine and leucine.
6. The antrodia camphorata hangover alleviating pill according to claim 1, wherein the vitamins are vitamin B1, vitamin B6, and vitamin C.
7. The antrodia camphorata hangover alleviating pill according to claim 1, wherein the flavoring agents are licorice, lily and reed rhizome.
8. The method for preparing antrodia camphorata anti-alcohol pill according to claim 1, comprising the steps of:
(1) weighing Antrodia Camphorata fruiting body or Antrodia Camphorata mycelium, adding anhydrous ethanol, reflux extracting, filtering to obtain filtrate, repeatedly extracting, and mixing filtrates to obtain Antrodia Camphorata ethanol extractive solution;
(2) evaporating ethanol in the Antrodia camphorata ethanol extract to dryness, and then performing microwave vacuum drying and crushing to obtain Antrodia camphorata ethanol extract powder;
(3) cutting radix Puerariae and correctant into pieces, and mashing semen Hoveniae;
(4) mixing mashed semen Hoveniae, sliced radix Puerariae and correctant, adding clear water, boiling, filtering, collecting filtrate, centrifuging, collecting supernatant, and vacuum freeze drying to obtain water extract powder;
(5) and (3) uniformly mixing the antrodia camphorata alcohol extract powder in the step (2) and the water extract powder in the step (4) with amino acid, vitamin, sweetening agent and stabilizing agent, and preparing pills.
9. The preparation method according to claim 8, wherein in the step (1), the antrodia camphorata fruiting body or the antrodia camphorata mycelium is preferably added with absolute ethyl alcohol according to the mass ratio of 1: 1-1: 50, is subjected to reflux extraction for 1-6 h in a water bath at 50-90 ℃, is filtered to obtain a filtrate, is subjected to repeated extraction twice and is combined with the filtrate to obtain the antrodia camphorata ethanol extract.
10. The preparation method according to claim 8, wherein the step (4) is carried out by adding clean water, boiling for 10-60 min, filtering with gauze, collecting filtrate, and centrifuging the filtrate at 4000-10000 r/min for 5-60 min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010883754.1A CN111956700A (en) | 2020-08-27 | 2020-08-27 | Antrodia camphorata anti-alcohol pill and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010883754.1A CN111956700A (en) | 2020-08-27 | 2020-08-27 | Antrodia camphorata anti-alcohol pill and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111956700A true CN111956700A (en) | 2020-11-20 |
Family
ID=73399692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010883754.1A Pending CN111956700A (en) | 2020-08-27 | 2020-08-27 | Antrodia camphorata anti-alcohol pill and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111956700A (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102450714A (en) * | 2010-10-22 | 2012-05-16 | 赵强 | Alcoholism-relieving drink and preparation method thereof |
| CN107669733A (en) * | 2016-08-01 | 2018-02-09 | 康力生技股份有限公司 | Chinese herbal medicine compound composition for improving alcoholism and application thereof |
-
2020
- 2020-08-27 CN CN202010883754.1A patent/CN111956700A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102450714A (en) * | 2010-10-22 | 2012-05-16 | 赵强 | Alcoholism-relieving drink and preparation method thereof |
| CN107669733A (en) * | 2016-08-01 | 2018-02-09 | 康力生技股份有限公司 | Chinese herbal medicine compound composition for improving alcoholism and application thereof |
Non-Patent Citations (4)
| Title |
|---|
| 吴晓冰等: "《解酒醒酒与护肝养胃》", 31 August 2007, 金盾出版社 * |
| 孙志慧: "《饮食宜忌与食物搭配大全》", 31 March 2014, 天津科学技术出版社 * |
| 李荣和等: "《大豆深加工的原理发现与技术发明》", 31 March 2017, 科学技术文献出版社 * |
| 谢玉玲: "《我最想要的老偏方》", 31 March 2012, 黑龙江科学技术出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101301094B1 (en) | Composition for relieving hangover or improving liver function | |
| KR101613693B1 (en) | Composition for Prevention or Treatment of Skin Disease Comprising an Extract of Sargassum Horneri and Method of Preparing The Same | |
| CN106551058B (en) | Preparation method of mulberry leaf tea capable of reducing blood sugar | |
| KR20130048917A (en) | Manufacturing method of beverage powder using cactus | |
| CN104560576B (en) | Maca health preserving wine and preparation method thereof | |
| CN105309979A (en) | Edible fungi functional beverage and preparation method thereof | |
| CN106343295B (en) | Raspberry beverage with slimming and beautifying functions and preparation method thereof | |
| CN111011833A (en) | Processing technology of ash tree pollen and ash tree pollen solid beverage | |
| CN113197315B (en) | A food composition for improving male sexual function, and its preparation method | |
| CN107557254B (en) | Litchi rose wine, preparation method and application of litchi rose wine in qi and blood tonifying and oxidation resistance | |
| CN107557204B (en) | Mixed brewed litchi rose wine and preparation method thereof | |
| KR101490211B1 (en) | Beverage for reducing alcoholic hangup and digester and method for preparation thereof | |
| CN110810693A (en) | A beverage composition containing Ampelopsis grossedentata and its preparation method | |
| CN111956700A (en) | Antrodia camphorata anti-alcohol pill and preparation method thereof | |
| KR102235563B1 (en) | Composition for fatigue recovery and sexual function improvement containing high content of arginine | |
| CN107637817A (en) | A kind of health-care honey powder and preparation method thereof | |
| KR101381277B1 (en) | The wild rice gel containing ginseng | |
| CN111150065A (en) | Application of sea-buckthorn water-soluble extract in preparation for inhibiting Tau protein phosphorylation | |
| KR20090098254A (en) | Method for producing artemisia extract by fermentation | |
| CN111296599A (en) | Traditional Chinese medicine health tea with auxiliary blood sugar reducing effect and preparation method thereof | |
| CN109717437A (en) | One kind is relieved the effect of alcohol compound honey paste and preparation method thereof | |
| KR102494072B1 (en) | Composition for improving or preventing depression comprising herbal extracts and method for preparing thereof | |
| KR102264978B1 (en) | Method for producing pear puree showing the effect of improving dysuria | |
| KR102330844B1 (en) | Composition For Improving Sexual Function Containing 17 Herbal Ingredients And Schisandra Chinensis, Rubus Coreanus, Lycium Chinense, Torilis Japonica, And Cuscuta Australis | |
| KR102428520B1 (en) | Manufacturing method of Liquor using Red Ginseng Concentrate, Angelica Extract, Chlorella and Perilla Frutescens Extract |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20201120 |
|
| RJ01 | Rejection of invention patent application after publication |