CN1119547A - Method for preparation of biofunctional medical adhesive-bonded fabric dressing and its products - Google Patents
Method for preparation of biofunctional medical adhesive-bonded fabric dressing and its products Download PDFInfo
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- CN1119547A CN1119547A CN 95108238 CN95108238A CN1119547A CN 1119547 A CN1119547 A CN 1119547A CN 95108238 CN95108238 CN 95108238 CN 95108238 A CN95108238 A CN 95108238A CN 1119547 A CN1119547 A CN 1119547A
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- alginate
- woven cloth
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Abstract
The present invention relates to a biofunctional medical adhesive-bonded fabric dressing and its making method and product. It is made up by using chitosamine-alginate mixed fibre pre-needling fabric as base layer, using alginate or other absorbent fibre pre-needled fabric as upper layer and making them pass through the process of double compound needling treatment on the main needle loom. Said invention is simple in manufacturing process, low in cost and high in finished product ratio, and has the several biofunctions of broad-spectrum bacteiostatic effect, promoting healing, reducing scar, hemostasis and combining the effects of chitosamine and alginate.
Description
The present invention relates to wound and use the dressing field, particularly the method for making of medical non-woven cloth with organism function dressing and goods thereof.
W089/12471 discloses the method for system Calcium Alginate fabric nonwoven cloth, this method makes the Calcium Alginate fiber by wet spinning technology, regulate calcium in the alginate/receive than with the Calcium Alginate that obtains being suitable for medical hemostatic dressing purposes/receive salt fiber by aftertreatment technology then, wherein, the salt content of receiving has determined to form the ability of Trostin M glue-line, calcium ion plays thrombin action, and this adhesive-bonded fabric dressing aftertreatment technology is complicated, and cost is higher.
EP0171254 discloses and chitin fiber has been carried out deacetylated, i.e. and mix with vinal after the high temperature alkali treatment and copy paper, or deacetylated being used as having the short more method of the medical dressing of effect after being made into cloth, wherein, deacetylated generation-NH
2Gene has higher biological activity and forms the ability of gel.The spy opens clear 62-170254 and chitosan fiber is carried out part recover acetyl group and handle, and promptly to contain the Glacial acetic acid dipping of methanol etc., mixes with vinal then and copies paper or be made into cloth to improve resistance to water.The processing cost of these two kinds of methods is all very high, and is undesirable aspect haemostatic effect.
CN1067279A discloses and has a kind ofly copied method and the goods thereof that are equipped with medical non-woven cloth with organism function made of paper with chitin fiber and alginate fiber mixing.But it is relatively poor that chitin fiber forms the ability of gel, and processing cost is higher than chitosan fiber and alginate fiber far away, bulk flexibility, figuration and the conformal poor-performing of gained paper shape wet nonwoven fabrics.
The objective of the invention is to: method for making and goods thereof that a kind of medical non-woven cloth with organism function dressing is provided.Bulk flexibility of this non-woven fabrics and good permeability, figuration and conformality are good, and the heat and moisture preserving performance is strong, and the living body adaptability energy is excellent and have hemostasis, the short effect of healing, reducing cicatrix concurrently, and preparation process is easy, reasonable, cost is low.
The objective of the invention is to reach like this: a kind of manufacture method of giving birth to body function medical adhesive-bonded fabric dressing is provided,, described method comprises the steps:
A) with the chitosan short fiber and wherein sodium ion and calcium ion weight ratio be 10: 90-30: 70 alginate short fiber mixes;
B) with a) step gained composite fibre through the carding machine carding, again through lapping, pre-pin is perverse, obtains chitosan-pre-needled non-woven cloth of alginate composite fibre;
C) wherein sodium ion and calcium ion weight ratio are 10: 90-30: 70 alginate short fiber or other hygroscopicity fibre are through the carding machine carding, again through lapping, pre-pin is perverse, obtains the pre-needled non-woven cloth of single alginate fiber or other hygroscopicity fibre;
D) with b) the made chitosan of step-pre-needled non-woven cloth of alginate composite fibre is bottom, with c) the pre-needled non-woven cloth of the made single alginate of step or other hygroscopicity fibre is the upper strata, perverse through the two-layer compound pin on the perverse machine of main pin, obtain medical non-woven cloth with organism function dressing.
The chitosan short fiber in a) step and the mixed proportion of alginate short fiber are:the chitosan short fiber accounts for the 5%-100% of chitosan short fiber and alginate short fiber gross weight. exists
C) other hygroscopicity fibre is a cotton fiber described in the step, vinylon fiber or viscose rayon.In a) dressing of medical non-woven cloth with organism function described in the step, as the weight per unit area of chitosan-alginate composite fibre non-woven fabrics be the 20-200 gram/square metre; As the weight per unit area of the single alginate on upper strata or its pre-needled non-woven cloth of hygroscopicity fibre be the 40-400 gram/square metre.
Another purpose of the present invention is reached like this, a kind of living body function medical adhesive-bonded fabric dressing goods are provided, described goods be with the chitosan short fiber and wherein sodium ion and calcium ion weight ratio be 10: 90-30: 70 alginate short fiber mixes after carding, the pre-perverse no gauze of chitosan-alginate composite fibre that lapping and pre-pin are perverse is as bottom, and be 10 with wherein sodium ion and calcium ion weight ratio: 90-30: 70 alginate short fiber or other hygroscopicity fibre are through carding, the single alginate that lapping and pre-pin are perverse or the pre-needled non-woven cloth of other hygroscopicity fibre are as the two-layer compound pin needled non-woven cloth dressing on upper strata.The mixed proportion of chitosan short fiber and alginate short fiber is in the prefabricated non-woven fabrics of chitosan-alginate composite fibre: the chitosan short fiber accounts for the 5-100% of chitosan short fiber and alginate short fiber gross weight.As other hygroscopicity fibre in the pre-needled non-woven cloth of other hygroscopicity fibre on upper strata is cotton fiber, vinylon fiber or viscose rayon.As the weight per unit area of the chitosan-pre-needled non-woven cloth of alginate composite fibre of bottom be the 20-200 gram/square metre; As the weight per unit area of the list-alginate on upper strata or the pre-needled non-woven cloth of other hygroscopicity fibre be the 40-400 gram/square metre.
The present invention is described in detail below in conjunction with embodiment.
Chitosan is the biopolymer that a kind of amido glucose constitutes, and is by being present in acetylglucosamine in the materials such as dried small shrimps, Carapax Eriocheir sinensis, Pupa bombycis skin through deacetylated and obtain.Modern medicine study shows, it has broad-spectrum antibacterial, be suppressed to fiber growth, promote the function of epidermal growth, thereby can play and protect from infection, reduce the effect of cicatrix, wherein sodium ion and calcium ion weight ratio are 10: 90-30: 70 alginate is the effective ingredient that extracts by in the brown Thallus Laminariae (Thallus Eckloniae), be the biopolymer salt that constitutes by mannuronic acid and gulonate, be rich in activated calcium composition as main thrombin, thereby have an excellent anastalsis, more than two kinds of biopolymer all have high liquid-absorbing, biocompatibility and biodegradation absorbability.Selected for use chitosan fiber to become non-woven fabrics with the alginate fiber hybrid process among the present invention, what time following main consideration is:
1) it is than chitin fiber cost low (than alginate fiber height);
2) it is stronger than the ability of chitin fiber formation gel, together play physics hemostasis and biochemistry hemostasis dual function with the activated calcium thrombin in the alginate, thereby can regulate calcium/sodium again than handling with the post-treatment of control gel formation ability by the Calcium Alginate fiber that wet spinning obtains;
3) it has broad-spectrum antibacterial, promotes the effect of healing, minimizing cicatrix.
Embodiment 1
With Carapax Eriocheir sinensis washing, the per 6.5 square centimeters of screen clothes that 50 holes are arranged of crushed after being dried process, 10 ℃ of following decalcifications are 30 minutes in 7.4% saline solution, washing back 85 ℃ of following deproteinizations 3 hours in 4%NaOH solution, be washed to the neutral chitin that gets, with chitin in 50% NaOH solution 100 ℃ down handle 4 hours after, with the hydrochloric acid neutralization, clean repeatedly, obtain chitosan after the drying.In 25 ℃ of acetums that chitosan are dissolved into 5% (percentage by volume), obtain 7% spinning solution, this stock solution after filtration, after the deaeration be that 0.08mm, hole count are that the spinneret in 2000 holes is expressed in the 10%NaOH aqueous solution with the aperture, tow is derived 1.4 times of first break draft with 6 meters/minute speed, obtain filament number 1.5d, the chitosan fiber of intensity 2.59/d through abundant washing and drying.With water-soluble 7% the spinning solution of being made into of Sodium Alginate, after the deaeration be that 0.10mm, hole count are that the spinneret in 10000 holes is expressed into solidified forming in the coagulating bath that contains 0.7% calcium chloride after filtration with the aperture, tow is derived 2.0 times of first break draft with 10 meters/minute speed, obtains filament number 1.5d, intensity 2.9g/d, wherein the part by weight of sodium ion and calcium ion is 50: 50 an alginate fiber.After two kinds of fibre cuttings are become the short fiber of 60 millimeters long, on carding machine,, be 30 gram/rice through lapping, the pre-perverse weight per unit area that obtains of pin with 50/50 mixed carding
2Composite fibre give needled non-woven cloth.With single alginate is raw material, and through same manufacturing procedure, making weight per unit area is 70 gram/rice
2The pre-needled non-woven cloth of alginate fiber.With the composite material non-woven fabrics is bottom, is the upper strata with the homogenous material non-woven fabrics, the described medical non-woven cloth with organism function dressing of system row after the two-layer compound pin is perverse on the perverse machine of main pin.The method for making of this medical adhesive-bonded fabric dressing and goods reach the object of the invention fully.
Embodiment 2
With the pre-needled non-woven cloth of embodiment 1 described composite fibre is bottom, is that the cotton fiber non-woven fabrics of 150 gram/rice 2 is the upper strata with weight per unit area, makes described organism function non-woven fabric medical dressing on the perverse machine of main pin after the two-layer compound pin is perverse.This non-woven fabrics is suitable for body surface purposes clinically, and cost is lower.
Embodiment 3
With embodiment 1 described chitosan short fiber carding on carding machine, be that the weight per unit area of raw material is 50 gram/rice through perverse the obtaining of lapping, pre-pin with single chitosan fiber
2Pre-pin needled non-woven cloth; With single alginate is raw material, and through same manufacturing procedure, making weight per unit area is 70 gram/rice
2The pre-needled non-woven cloth of alginate fiber be bottom with the pre-pin needled non-woven cloth of single chitosan fiber, be the upper strata with the pre-needled non-woven cloth of single alginate fiber, making described living body merit non-woven fabric medical dressing through the two-layer compound pin after perverse on the perverse machine of main pin.Prepared goods reach the object of the invention equally.
The present invention has good effect. The used crust of the present invention-alginate composite fibre is made Dry method pin needled non-woven cloth copy paper gained nonwoven with wet method and compare, have bulk gentle pine and good permeability, Figuration and the strong advantage of conformal performance; Compare simple process, yield rate height, cost with weaving process Reduce the simultaneously comprehensive chitosan of medical non-woven cloth with organism function dressing procucts of the present invention and alginate Several functions and strengthen hemostatic function, have broad-spectrum antibacterial concurrently, promoting healing reduces scar, has High liquid-absorbing, biocompatibility and biodegradation absorbability, and have good plastic property and conformal Performance.
Claims (8)
1, the manufacture method of medical non-woven cloth with organism function dressing is characterized in that having the following steps:
A) with the chitosan short fiber and wherein sodium ion and calcium ion weight ratio be 10: 90-30: 70 alginate short fiber mixes;
B) with a) step gained composite fibre is through the carding machine carding, again through lapping, pre-needling obtains chitosan-pre-needled non-woven cloth of alginate composite fibre;
C) wherein sodium ion and calcium ion weight ratio are 10: 90-30: 70 alginate short fiber or other hygroscopicity fibre are through the carding machine carding, again through lapping, pre-pin is perverse, obtains the pre-needled non-woven cloth of single alginate fiber or other hygroscopicity fibre;
D) with b) the made chitosan of step-pre-needled non-woven cloth of alginate composite fibre is bottom, with c) the pre-needled non-woven cloth of the made single alginate of step or other hygroscopicity fibre is the upper strata, perverse through the two-layer compound pin on the perverse machine of main pin, obtain medical non-woven cloth with organism function dressing.
2, according to the manufacture method of the described living body function medical adhesive-bonded fabric dressing of claim 1, it is characterized in that: the chitosan short fiber in a) step and the mixed proportion of alginate short fiber are: the chitosan short fiber accounts for the 5%-100% of chitosan short fiber and alginate short fiber gross weight.
3, according to the manufacture method of the described medical non-woven cloth with organism function dressing of claim 1, it is characterized in that: at c) other hygroscopicity fibre described in the step is cotton fiber, vinylon fiber or viscose rayon.
4, according to the manufacture method of each described medical non-woven cloth with organism function dressing of claim 1-3, it is characterized in that: in a) dressing of medical non-woven cloth with organism function described in the step, as the weight per unit area of chitosan-alginate composite fibre non-woven fabrics be the 20-200 gram/square metre; As the weight per unit area of the single alginate on upper strata or its pre-needled non-woven cloth of hygroscopicity fibre be the 40-400 gram/square metre.
5, the medical non-woven cloth with organism function dressing procucts is characterized in that: described goods be with the chitosan short fiber and wherein sodium ion and calcium ion weight ratio be 10: 90-30: 70 alginate short fiber mixes after carding, the pre-needled non-woven cloth of chitosan-alginate composite fibre that lapping and pre-pin are perverse is as bottom, with wherein sodium ion and calcium ion weight ratio is 10: 90-30: 70 alginate short fiber or other hygroscopicity fibre are through carding, the single alginate that lapping and pre-pin are perverse or the pre-needled non-woven cloth of other hygroscopicity fibre are as the two-layer compound pin needled non-woven cloth dressing on upper strata.
6, according to the described medical non-woven cloth with organism function dressing procucts of claim 5, it is characterized in that: in the prefabricated non-woven fabrics of chitosan-alginate composite fibre, the mixed proportion of chitosan short fiber and alginate short fiber is: the chitosan short fiber accounts for the 5-100% of chitosan short fiber and alginate short fiber gross weight.
7, according to the described medical non-woven cloth with organism function dressing procucts of claim 5, it is characterized in that: as other hygroscopicity fibre in the pre-needled non-woven cloth of other hygroscopicity fibre on upper strata is cotton fiber, vinylon fiber or viscose rayon.
8, according to each described living body function medical adhesive-bonded fabric dressing goods of claim 5-7, it is characterized in that: as the weight per unit area of the chitosan-pre-needled non-woven cloth of alginate composite fibre of bottom be the 20-200 gram/square metre; As the weight per unit area of the single alginate on upper strata or the pre-needled non-woven cloth of other hygroscopicity fibre be the 40-400 gram/square metre.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95108238A CN1056087C (en) | 1995-07-28 | 1995-07-28 | Method for preparation of biofunctional medical adhesive-bonded fabric dressing and its products |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95108238A CN1056087C (en) | 1995-07-28 | 1995-07-28 | Method for preparation of biofunctional medical adhesive-bonded fabric dressing and its products |
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| Publication Number | Publication Date |
|---|---|
| CN1119547A true CN1119547A (en) | 1996-04-03 |
| CN1056087C CN1056087C (en) | 2000-09-06 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95108238A Expired - Fee Related CN1056087C (en) | 1995-07-28 | 1995-07-28 | Method for preparation of biofunctional medical adhesive-bonded fabric dressing and its products |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110477A (en) * | 2013-02-25 | 2013-05-22 | 苏州艾美医疗用品有限公司 | Manufacturing method of composite medical non-woven fabric absorbent pads |
| CN106902380A (en) * | 2017-03-15 | 2017-06-30 | 张太平 | A kind of medical wet combine dressing |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1032237C (en) * | 1991-10-11 | 1996-07-10 | 青岛海洋大学 | Biological material sponge producing process |
| CN1038644C (en) * | 1991-11-26 | 1998-06-10 | 曹应龙 | Production method of burn and scald gel |
-
1995
- 1995-07-28 CN CN95108238A patent/CN1056087C/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103110477A (en) * | 2013-02-25 | 2013-05-22 | 苏州艾美医疗用品有限公司 | Manufacturing method of composite medical non-woven fabric absorbent pads |
| CN103110477B (en) * | 2013-02-25 | 2014-03-26 | 苏州艾美医疗用品有限公司 | Manufacturing method of composite medical non-woven fabric absorbent pads |
| CN106902380A (en) * | 2017-03-15 | 2017-06-30 | 张太平 | A kind of medical wet combine dressing |
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| Publication number | Publication date |
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| CN1056087C (en) | 2000-09-06 |
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