CN111918869A - 甘草酸衍生物的结晶、其结晶组合物、药物组合物及用途 - Google Patents
甘草酸衍生物的结晶、其结晶组合物、药物组合物及用途 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
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- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
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- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C07H15/256—Polyterpene radicals
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
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Abstract
本申请属于医药技术领域，涉及甘草酸衍生物的结晶、其结晶组合物、药物组合物及用途，具体涉及异甘草酸镁的A型结晶、B型结晶、C型结晶、D型结晶、E型结晶，以及所述结晶的制备方法、包含所述结晶的结晶组合物和药物组合物以及它们的用途。本申请制备得到的结晶，克服了按照现有技术制备得到的式I化合物固体结块、难于过滤及干燥、澄清度差等缺点，适合工业化生产，并提高产品的安全性。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310460830.1A CN116621908A (zh) | 2018-04-13 | 2019-04-12 | 甘草酸衍生物的结晶、其结晶组合物、药物组合物及用途 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810331882 | 2018-04-13 | ||
| CN2018103318828 | 2018-04-13 | ||
| PCT/CN2019/082400 WO2019196920A1 (zh) | 2018-04-13 | 2019-04-12 | 甘草酸衍生物的结晶、其结晶组合物、药物组合物及用途 |
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| CN202310460830.1A Division CN116621908A (zh) | 2018-04-13 | 2019-04-12 | 甘草酸衍生物的结晶、其结晶组合物、药物组合物及用途 |
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| Publication Number | Publication Date |
|---|---|
| CN111918869A true CN111918869A (zh) | 2020-11-10 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980025144.3A Pending CN111918869A (zh) | 2018-04-13 | 2019-04-12 | 甘草酸衍生物的结晶、其结晶组合物、药物组合物及用途 |
| CN202310460830.1A Pending CN116621908A (zh) | 2018-04-13 | 2019-04-12 | 甘草酸衍生物的结晶、其结晶组合物、药物组合物及用途 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310460830.1A Pending CN116621908A (zh) | 2018-04-13 | 2019-04-12 | 甘草酸衍生物的结晶、其结晶组合物、药物组合物及用途 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US11292809B2 (zh) |
| CN (2) | CN111918869A (zh) |
| WO (1) | WO2019196920A1 (zh) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1381462A (zh) * | 2002-05-16 | 2002-11-27 | 吴锡铭 | 新的化合物异甘草酸盐及其生产方法 |
| CN1169826C (zh) * | 2002-05-16 | 2004-10-06 | 吴锡铭 | 一种新的化合物异甘草酸镁及其生产方法和用途 |
| CN104861031A (zh) * | 2015-03-16 | 2015-08-26 | 李玉山 | 一种异甘草酸镁的制备方法 |
| CN105616376A (zh) * | 2016-02-26 | 2016-06-01 | 正大天晴药业集团股份有限公司 | 含异甘草酸镁药物的组合物及制备方法 |
-
2019
- 2019-04-12 WO PCT/CN2019/082400 patent/WO2019196920A1/zh active Application Filing
- 2019-04-12 US US17/047,292 patent/US11292809B2/en active Active
- 2019-04-12 CN CN201980025144.3A patent/CN111918869A/zh active Pending
- 2019-04-12 CN CN202310460830.1A patent/CN116621908A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1381462A (zh) * | 2002-05-16 | 2002-11-27 | 吴锡铭 | 新的化合物异甘草酸盐及其生产方法 |
| CN1169826C (zh) * | 2002-05-16 | 2004-10-06 | 吴锡铭 | 一种新的化合物异甘草酸镁及其生产方法和用途 |
| CN104861031A (zh) * | 2015-03-16 | 2015-08-26 | 李玉山 | 一种异甘草酸镁的制备方法 |
| CN105616376A (zh) * | 2016-02-26 | 2016-06-01 | 正大天晴药业集团股份有限公司 | 含异甘草酸镁药物的组合物及制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN116621908A (zh) | 2023-08-22 |
| WO2019196920A1 (zh) | 2019-10-17 |
| US11292809B2 (en) | 2022-04-05 |
| US20210317155A1 (en) | 2021-10-14 |
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