CN111918658A - 利用循环微粒相关生物标志物早期预测和预防先兆子痫的方法 - Google Patents

利用循环微粒相关生物标志物早期预测和预防先兆子痫的方法 Download PDF

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CN111918658A
CN111918658A CN201980022348.1A CN201980022348A CN111918658A CN 111918658 A CN111918658 A CN 111918658A CN 201980022348 A CN201980022348 A CN 201980022348A CN 111918658 A CN111918658 A CN 111918658A
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biomarkers
human
preeclampsia
protein
risk
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CN201980022348.1A
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Chinese (zh)
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K·P·罗森布拉特
T·F·麦克尔拉思
B·D·布罗曼
R·C·多斯
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Brigham and Womens Hospital Inc
NX Prenatal Inc
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Brigham and Womens Hospital Inc
NX Prenatal Inc
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
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    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
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    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
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    • G01N30/02—Column chromatography
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    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
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CN201980022348.1A 2018-01-31 2019-01-31 利用循环微粒相关生物标志物早期预测和预防先兆子痫的方法 Pending CN111918658A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862624626P 2018-01-31 2018-01-31
US62/624,626 2018-01-31
US201862641135P 2018-03-09 2018-03-09
US62/641,135 2018-03-09
PCT/US2019/016188 WO2019152741A1 (en) 2018-01-31 2019-01-31 Methods of early prediction and prevention of preeclampsia utilizing circulating microparticle-associated biomarkers

Publications (1)

Publication Number Publication Date
CN111918658A true CN111918658A (zh) 2020-11-10

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CN201980022348.1A Pending CN111918658A (zh) 2018-01-31 2019-01-31 利用循环微粒相关生物标志物早期预测和预防先兆子痫的方法

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US (2) US20210050112A1 (https=)
EP (1) EP3746087A4 (https=)
JP (1) JP2021512315A (https=)
KR (1) KR20200140796A (https=)
CN (1) CN111918658A (https=)
SG (1) SG11202007319SA (https=)
WO (1) WO2019152741A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022015666A1 (en) * 2020-07-13 2022-01-20 Nx Prenatal Inc. Methods of assessing risk of and treating preeclampsia and subtypes thereof
JP2024546438A (ja) * 2021-11-11 2024-12-24 エヌエックス・プリネイタル・インコーポレイテッド 癒着胎盤に関連するバイオマーカーについてサンプルを調製および分析する方法
CN119422206A (zh) * 2022-06-21 2025-02-11 Neo预见科技股份有限公司 子痫前期演变预测、方法和系统
CN117747110B (zh) * 2023-12-26 2024-11-15 南京鼓楼医院 基于母体因素和早期孕期生物标志物的子痫前期风险预测方法及系统
DE102024100425A1 (de) * 2024-01-09 2025-07-10 Charité - Universitätsmedizin Berlin Körperschaft des öffentlichen Rechts Verfahren und System zur Klassifikation eines Auftretens einer medizinischen Komplikation

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014105985A1 (en) * 2012-12-28 2014-07-03 NX Pharmagen Biomarkers of preterm birth
US20160025739A1 (en) * 2013-03-12 2016-01-28 Agency For Science, Technology And Research Pre-eclampsia biomarkers
US20160369339A1 (en) * 2013-07-01 2016-12-22 Cindy Anderson Biomarker for preeclampsia
WO2016205723A2 (en) * 2015-06-19 2016-12-22 Sera Prognostics, Inc. Biomarker pairs for predicting preterm birth
US20170037093A1 (en) * 2015-07-01 2017-02-09 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
WO2017096405A1 (en) * 2015-12-04 2017-06-08 Nx Prenatal Inc. Use of circulating microparticles to stratify risk of spontaneous preterm birth

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009097584A1 (en) * 2008-01-30 2009-08-06 Proteogenix, Inc. Maternal serum biomarkers for detection of pre-eclampsia
PL3189336T3 (pl) * 2014-09-02 2019-07-31 Wallac Oy Sposób określania ryzyka stanu przedrzucawkowego

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014105985A1 (en) * 2012-12-28 2014-07-03 NX Pharmagen Biomarkers of preterm birth
US20160025739A1 (en) * 2013-03-12 2016-01-28 Agency For Science, Technology And Research Pre-eclampsia biomarkers
US20160369339A1 (en) * 2013-07-01 2016-12-22 Cindy Anderson Biomarker for preeclampsia
WO2016205723A2 (en) * 2015-06-19 2016-12-22 Sera Prognostics, Inc. Biomarker pairs for predicting preterm birth
US20170037093A1 (en) * 2015-07-01 2017-02-09 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
WO2017096405A1 (en) * 2015-12-04 2017-06-08 Nx Prenatal Inc. Use of circulating microparticles to stratify risk of spontaneous preterm birth

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HIAN TAN K等: "Plasma biomarker discovery in pre-eclampsia using a novel differential isolation technology for circulating extracellular vesicles" *
SANDRA A. FOUNDS等: "Gene Expression in First Trimester Preeclampsia Placenta" *
SHREY KOHLI等: "Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts" *

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Publication number Publication date
KR20200140796A (ko) 2020-12-16
SG11202007319SA (en) 2020-08-28
US20210050112A1 (en) 2021-02-18
JP2021512315A (ja) 2021-05-13
EP3746087A4 (en) 2022-02-09
WO2019152741A1 (en) 2019-08-08
EP3746087A1 (en) 2020-12-09
US20250329468A1 (en) 2025-10-23

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Application publication date: 20201110