CN111903694A - Pesticide nano carrier system for preventing and controlling pine cone pests and preparation method thereof - Google Patents
Pesticide nano carrier system for preventing and controlling pine cone pests and preparation method thereof Download PDFInfo
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- CN111903694A CN111903694A CN202010774635.2A CN202010774635A CN111903694A CN 111903694 A CN111903694 A CN 111903694A CN 202010774635 A CN202010774635 A CN 202010774635A CN 111903694 A CN111903694 A CN 111903694A
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/12—Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
The present disclosure relates to a pesticide nano drug-loading system for controlling pine cone pests, which is characterized in that the pesticide nano drug-loading system comprises nanoparticles and active ingredients encapsulated in the nanoparticles; the nanoparticle consists of a carrier material and auxiliary components, wherein the effective components comprise 1 part by weight of natural pyrethrin and 0.1-40 parts by weight of azadirachtin. Through the technical scheme, the pesticide nano drug delivery system provided by the disclosure has an obvious sustained and controlled release effect and can prolong the drug duration; meanwhile, the pesticide nano drug-loading system has strong blade affinity, can be well attached to crop blades, and avoids the phenomenon that a large amount of pesticide drops enter the natural environment to pollute the natural environment, so that the pesticide nano drug-loading system disclosed by the invention reduces the dosage, improves the drug effect, and has obvious effects on relieving the environmental pollution caused by pesticide abuse, the drug resistance of pests, the loss of biological diversity and the like.
Description
Technical Field
The disclosure relates to the technical field of pesticide production, in particular to a pesticide nano drug-loading system for preventing and treating pine cone pests and a preparation method thereof.
Background
The pesticide is an important resource for agricultural generation, and the application of the pesticide is an important means for preventing and controlling crop diseases and insect pests and regulating the growth of crops, and has important significance for the yield conservation and the yield increase of agricultural production. Most pesticides are unstable and easy to degrade under natural conditions, so that the pesticide has short duration and low utilization rate; moreover, the surfaces of most crop leaves have hydrophobic micro-nano structures such as wax layers, villi, mastoids and the like, pesticide liquid drops are difficult to attach to the crop leaves and fall off into the natural environment, the pesticide utilization rate is further reduced, meanwhile, the pesticide falling off into the natural environment causes environmental pollution, the health of human beings is threatened, and the pesticide resistance of harmful organisms is also induced. Therefore, it is necessary to develop a novel pesticide formulation to increase the pesticide effect, increase the amount of the pesticide adhering to the plant leaves, and reduce the amount of the pesticide used.
The nano material has the characteristics of small size effect, surface interface effect, quantum size effect, quantum tunneling effect and the like, and shows excellent characteristics which are not possessed by a plurality of traditional materials. The application research of the nanotechnology in agriculture forms a very active new cross discipline, wherein the nanotechnology is combined with the development of pesticides, and the nanometer materials and the technology are utilized to develop new dosage forms of the nanometer pesticides, so that the nanometer pesticide preparation is one of the research hotspots in the field of the application of the nanotechnology agriculture in the international state at present, forms a new research field of the nanometer pesticides, shows good application prospects in the aspects of relieving environmental pollution, pest drug resistance, biological diversity loss and the like caused by pesticide abuse, greatly reduces the dosage, improves the drug effect and breaks through on the use economy.
Disclosure of Invention
The invention aims to provide a pesticide nano drug-loading system for preventing and controlling pine cone pests and a preparation method thereof.
In order to achieve the above objects, in a first aspect, the present disclosure provides a pesticide nano drug delivery system for controlling pine cone pests, comprising nanoparticles and an active ingredient encapsulated in the nanoparticles; the nanoparticle consists of a carrier material and auxiliary components, wherein the effective components comprise 1 part by weight of natural pyrethrin and 0.1-40 parts by weight of azadirachtin.
Optionally, the effective component comprises 1 part by weight of natural pyrethrin and 0.5-10 parts by weight of azadirachtin.
Optionally, the average particle size of the pesticide nano drug delivery system is 78.6-157.9nm, the drug loading rate is 4.4-53.7%, and the encapsulation rate is 68.9-93.5%; preferably, the average particle size of the pesticide nano drug delivery system is 95.3-125.4nm, the drug loading rate is 18.2-36.7%, and the encapsulation rate is 78.4-88.7%.
Optionally, the carrier material comprises at least one of monomethoxypolyethylene glycol-polylactic acid-glycolic acid block copolymer, polyethylene oxide-polylactic acid-glycolic acid block copolymer, polyacrylamide-polylactic acid-glycolic acid block copolymer and polymethyl methacrylate; preferably, the carrier material comprises at least one of monomethoxypolyethylene glycol-polylactic acid-glycolic acid block copolymer, polyacrylamide-polylactic acid-glycolic acid block copolymer and polymethyl methacrylate.
Optionally, the adjunct ingredients include an emulsifier and a wetting agent.
Alternatively, the auxiliary ingredient is used in an amount of 0.06-0.6 parts by weight relative to 1 part by weight of the carrier material.
In a second aspect, the present disclosure provides a method for preparing the pesticide nano drug-loaded system of any one of the first aspect, the method comprising:
a. dissolving the carrier material and the auxiliary component in an organic solvent to obtain a carrier solution;
b. dissolving the effective components in an organic solvent to obtain an effective component solution;
c. and mixing the carrier solution and the effective component solution, and stirring for 30-60min at the rotating speed of 300-500 rpm to obtain the pesticide nano drug-carrying system.
Optionally, the organic solvent comprises at least one of acetone, ethyl acetate, N-octyl pyrrolidone, N-dimethylformamide, and N, N-dimethyldecanamide.
Alternatively, in step a, the organic solvent is used in an amount of 0.5 to 3 parts by weight, relative to 1 part by weight of the mixture of the support material and the auxiliary ingredient;
in the step b, the organic solvent is used in an amount of 0.5 to 2.5 parts by weight relative to 1 part by weight of the active ingredient.
Alternatively, in step c, the effective ingredient solution is used in an amount of 0.1 to 5 parts by volume relative to 1 part by volume of the carrier solution.
By adopting the technical scheme, the pesticide nano drug delivery system provided by the disclosure has an obvious sustained and controlled release effect and a longer drug duration; meanwhile, the pesticide nano drug-loaded system has strong affinity to leaves and can be well attached to the leaves of crops, which is helpful for preventing a large amount of pesticide liquid from entering the natural environment to pollute the natural environment, therefore, the pesticide nano drug-loaded system disclosed by the invention has the characteristics of low dosage, high pesticide effect and long lasting period, and is helpful for relieving the problems of environmental pollution, pesticide resistance of pests, biological diversity loss and the like caused by pesticide abuse.
Additional features and advantages of the disclosure will be set forth in the detailed description which follows.
Detailed Description
The following describes in detail specific embodiments of the present disclosure. It should be understood that the detailed description and specific examples, while indicating the present disclosure, are given by way of illustration and explanation only, not limitation.
The first aspect of the present disclosure provides a pesticide nano drug-carrying system for controlling pine cone pests, which comprises nanoparticles and an active ingredient encapsulated in the nanoparticles; the nanoparticle consists of a carrier material and auxiliary components, wherein the effective components comprise 1 part by weight of natural pyrethrin and 0.1-40 parts by weight of azadirachtin.
In the technical scheme, the active ingredients are encapsulated in the nanoparticles, so that the problems of drug failure, low utilization rate and the like caused by the fact that the active ingredients are directly exposed in the natural environment and degraded can be avoided; meanwhile, the nanoparticles have slow release and controlled release effects, can continuously release effective components for a long time, and prolong the lasting period of the medicine; the nanoparticles also have blade affinity, can be well attached to crop blades, and prevent a large amount of pesticide droplets from entering the natural environment to pollute the natural environment. Therefore, the pesticide nano drug delivery system disclosed by the invention has the characteristics of low dosage, higher drug effect and long lasting period, and is beneficial to relieving the problems of environmental pollution, pest drug resistance, biological diversity loss and the like caused by pesticide abuse.
Meanwhile, in the pesticide nano drug delivery system, the effective components comprise 1 part by weight of natural pyrethrin and 0.1-40 parts by weight of azadirachtin, the natural pyrethrin and the azadirachtin within the dosage range have a synergistic effect, and compared with the single use of any one of the natural pyrethrin and the azadirachtin, the combined use of the two components within the dosage range can more effectively repel pests, prevent and treat diseases, strengthen seedlings and promote the growth of a regulator.
According to the present disclosure, in order to further increase the synergistic effects of natural pyrethrin and azadirachtin, further reduce the dosage and enhance the effect of agricultural chemicals, it is preferable that the effective ingredients include 1 part by weight of natural pyrethrin and 0.5-10 parts by weight of azadirachtin.
According to the present disclosure, the average particle size, drug loading rate, encapsulation rate, etc. of the pesticide nano drug-loading system can be varied within a wide range, for example, the average particle size of the pesticide nano drug-loading system can be 78.6-157.9nm, the drug loading rate can be 4.4-53.7%, and the encapsulation rate can be 68.9-93.5%; preferably, the average particle size of the pesticide nano drug delivery system can be 95.3-125.4nm, the drug loading rate can be 18.2-36.7%, and the encapsulation rate can be 78.4-88.7%. Within the preferable range, the pesticide nano drug-carrying system has better sustained and controlled release effects.
According to the present disclosure, the carrier material constituting the above nanoparticles may be selected from a wide range, for example, the carrier material may include at least one of monomethoxypolyethylene glycol-polylactic acid-glycolic acid block copolymer, polyethylene oxide-polylactic acid-glycolic acid block copolymer, polyacrylamide-polylactic acid-glycolic acid block copolymer, and polymethyl methacrylate; preferably, the carrier material comprises at least one of monomethoxypolyethylene glycol-polylactic acid-glycolic acid block copolymer, polyacrylamide-polylactic acid-glycolic acid block copolymer and polymethyl methacrylate. Under the optimal condition, the pesticide nano drug delivery system has better sustained-release and controlled-release effects and better leaf affinity.
The types of auxiliary ingredients that make up the nanoparticles described above can be selected within a wide range in accordance with the present disclosure, for example, the auxiliary ingredients can include emulsifying and wetting agents.
In accordance with the present disclosure, the relative amounts of carrier material and auxiliary ingredient in the above nanoparticles may vary within wide limits, for example, the auxiliary ingredient may be used in an amount of 0.06-0.6 parts by weight relative to 1 part by weight of the carrier material.
A second aspect of the present disclosure provides a method for preparing the pesticide nano drug-delivery system of any one of the first aspects, the method comprising: a. dissolving the carrier material and the auxiliary component in an organic solvent to obtain a carrier solution; b. dissolving the effective components in an organic solvent to obtain an effective component solution; c. and mixing the carrier solution and the effective component solution, and stirring for 30-60min at the rotating speed of 300-500 rpm to obtain the pesticide nano drug-carrying system.
Optionally, the organic solvent comprises at least one of acetone, ethyl acetate, N-octyl pyrrolidone, N-dimethylformamide, and N, N-dimethyldecanamide.
Alternatively, in step a, the organic solvent is used in an amount of 0.5 to 3 parts by weight, relative to 1 part by weight of the mixture of the support material and the auxiliary ingredient; in the step b, the organic solvent is used in an amount of 0.5 to 2.5 parts by weight relative to 1 part by weight of the active ingredient.
Alternatively, in step c, the effective ingredient solution is used in an amount of 0.1 to 5 parts by volume relative to 1 part by volume of the carrier solution.
The present disclosure is further illustrated by the following examples, but is not to be construed as being limited thereby. The raw materials, reagents, instruments and equipment involved in the examples of the present disclosure may be commercially available, unless otherwise specified.
Example 1
Mixing a carrier material (monomethoxy polyethylene glycol-polylactic acid-glycolic acid block copolymer) and an auxiliary component (sodium dodecyl benzene sulfonate) according to a weight ratio of 1: 0.1 mixing, and dissolving in an organic solvent (N, N-dimethyldecanamide) to obtain a carrier solution, wherein the amount of the organic solvent is 1 part by weight relative to 1 part by weight of the mixture of the carrier material and the auxiliary component; dissolving effective components (1 part by weight of natural pyrethrin and 1 part by weight of azadirachtin) in organic solvent (acetone) to obtain effective component solution, wherein the amount of organic solvent is 1 part by weight relative to 1 part by weight of effective components; mixing the carrier solution and the effective component solution according to the volume ratio of 2.5: 1, mixing, and stirring at a rotating speed of 400 rpm for 40min to obtain the pesticide nano drug-loading system of the embodiment.
Through detection, the average particle size of the pesticide nano drug delivery system prepared by the embodiment is 98.9nm, the drug loading rate is 28.9%, and the encapsulation rate is 85.7%.
Example 2
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the effective components comprise 1 weight part of natural pyrethrin and 10 weight parts of azadirachtin.
Example 3
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the effective components comprise natural pyrethrin 1 weight part and azadirachtin 0.5 weight part.
Example 4
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the effective components comprise 1 weight part of natural pyrethrin and 40 weight parts of azadirachtin.
Example 5
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the effective components comprise natural pyrethrin 1 weight part and azadirachtin 0.1 weight part.
Example 6
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the carrier material used in this example was a polyethylene glycol-polylactic acid-glycolic acid block copolymer.
Example 7
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the carrier material used in this example was a polyethylene oxide-polylactic acid-glycolic acid block copolymer.
Example 8
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the carrier material used in this example was a polyacrylamide-polylactic acid-glycolic acid block copolymer.
Example 9
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the average particle size of the pesticide nano drug delivery system prepared by the embodiment is 78.6nm, the drug loading rate is 4.4%, and the encapsulation rate is 68.9%.
Example 10
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the average particle size of the pesticide nano drug delivery system prepared by the embodiment is 157.9nm, the drug loading rate is 53.7%, and the encapsulation rate is 93.5%.
Example 11
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the average particle size of the pesticide nano drug delivery system prepared by the embodiment is 95.3nm, the drug loading rate is 18.2%, and the encapsulation rate is 78.4%.
Example 12
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the average particle size of the pesticide nano drug delivery system prepared by the embodiment is 125.4nm, the drug loading rate is 36.7%, and the encapsulation rate is 88.7%.
Comparative example 1
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the effective ingredients in example 1 were replaced with the same amount of natural pyrethrin.
Comparative example 2
The method for preparing the pesticide nano drug-loaded system in the embodiment 1 is different from the method in the embodiment 1 in that: the effective ingredients in example 1 were replaced with the same amount of azadirachtin.
Comparative example 3
After mixing 1 part by weight of natural pyrethrin and 1 part by weight of azadirachtin, an emulsifiable concentrate was prepared according to a conventional method in the art.
Comparative example 4
After mixing 1 part by weight of natural pyrethrin and 1 part by weight of azadirachtin, water dispersible granules were prepared according to the conventional method in the art.
Comparative example 5
Mixing 1 part by weight of natural pyrethrin and 1 part by weight of azadirachtin, and preparing powder according to the conventional method in the field.
Test examples
The test example uses the pesticide preparations prepared in examples 1 to 12 and comparative examples 1 to 5 as test samples to test the control effect of the pesticide preparations on the fruit tip borer.
Test site: the test forest area is the Changbai mountain forest area of the Korean autonomous State of extended frontier of Jilin province, the soil fertility of the forest area is better, and the growth conditions of the trees are uniform. The test forest area belongs to a coniferous and broadleaf mixed forest, the average slope is 30 degrees, the red pine in the test forest area is used as a test object, the tree age of the red pine is more than 200 years, and the plant height is 25-30 m. About 15 pinus koraiensis are distributed in each mu of test forest area, about 70% of pinus koraiensis cones are subjected to insect pests, and 5-6 pests are distributed on each cone subjected to the insect pests.
The test method comprises the following steps: the experimental forest area is divided into 18 experimental plots, the area of each experimental plot is 50 mu, 17 experimental plots are used as experimental groups, the pesticide preparations prepared in examples 1-12 and comparative examples 1-5 are respectively applied, and the rest 1 experimental plot is used as a control group and is applied with clear water. In each test cell, the application amount of the pesticide preparations prepared in examples 1 to 12 and comparative examples 1 to 5 was 50mL, and the pesticide preparations were diluted 100 times with clear water and sprayed by a helicopter.
Respectively selecting 5 red pines in each test cell by adopting a five-point sampling method after 1 day, 7 days, 14 days and 21 days after the application of the pesticide, randomly selecting 5 red pine cones on each red pine, counting the number of the young leaf rollers in the cones, and calculating the control effect in each test cell, wherein the results are shown in table 1. The control effect of each test cell was calculated as follows:
control effect (%) - (reduction rate of population of insects in experimental group-reduction rate of population of insects in control group)/(reduction rate of population of insects in 1-control group) × 100
TABLE 1
As can be seen from table 1, the pesticide nano drug delivery system provided by the present disclosure has a good control effect on pine cone pests, and has a longer duration.
The preferred embodiments of the present disclosure have been described in detail above, however, the present disclosure is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present disclosure within the technical idea of the present disclosure, and these simple modifications all fall within the protection scope of the present disclosure.
It should be noted that the various features described in the above embodiments may be combined in any suitable manner without departing from the scope of the invention.
In addition, any combination of various embodiments of the present disclosure may be made, and the same should be considered as the disclosure of the present disclosure, as long as it does not depart from the spirit of the present disclosure.
Claims (10)
1. A pesticide nano drug-loading system for preventing and controlling pine cone pests is characterized by comprising nanoparticles and active ingredients encapsulated in the nanoparticles; the nanoparticle consists of a carrier material and auxiliary components, wherein the effective components comprise 1 part by weight of natural pyrethrin and 0.1-40 parts by weight of azadirachtin.
2. The pesticide nano drug delivery system of claim 1, wherein the effective ingredients comprise 1 part by weight of natural pyrethrin and 0.5-10 parts by weight of azadirachtin.
3. The pesticide nano-drug delivery system of claim 1, which is characterized in that the mean particle size of the pesticide nano-drug delivery system is 78.6-157.9nm, the drug loading rate is 4.4-53.7%, and the encapsulation efficiency is 68.9-93.5%; preferably, the average particle size of the pesticide nano drug delivery system is 95.3-125.4nm, the drug loading rate is 18.2-36.7%, and the encapsulation rate is 78.4-88.7%.
4. The pesticide nano drug delivery system of claim 1, wherein the carrier material comprises at least one of monomethoxypolyethylene glycol-polylactic acid-glycolic acid block copolymer, polyethylene oxide-polylactic acid-glycolic acid block copolymer, polyacrylamide-polylactic acid-glycolic acid block copolymer and polymethyl methacrylate; preferably, the carrier material comprises at least one of monomethoxypolyethylene glycol-polylactic acid-glycolic acid block copolymer, polyacrylamide-polylactic acid-glycolic acid block copolymer and polymethyl methacrylate.
5. The pesticide nano drug delivery system of claim 1, wherein the adjuvant comprises an emulsifier and a wetting agent.
6. The pesticidal nanoparticie system of claim 5, wherein the adjuvant is used in an amount of 0.06-0.6 parts by weight relative to 1 part by weight of the carrier material.
7. A method for preparing the pesticide nano-drug delivery system of any one of claims 1 to 6, which is characterized by comprising the following steps:
a. dissolving the carrier material and the auxiliary component in an organic solvent to obtain a carrier solution;
b. dissolving the effective components in an organic solvent to obtain an effective component solution;
c. and mixing the carrier solution and the effective component solution, and stirring for 30-60min at the rotating speed of 300-500 rpm to obtain the pesticide nano drug-carrying system.
8. The method of claim 7, wherein the organic solvent comprises at least one of acetone, ethyl acetate, N-octyl pyrrolidone, N-dimethylformamide, and N, N-dimethyldecanamide.
9. The process according to claim 7, wherein in step a, the organic solvent is used in an amount of 0.5 to 3 parts by weight, relative to 1 part by weight of the mixture of carrier material and auxiliary components;
in the step b, the organic solvent is used in an amount of 0.5 to 2.5 parts by weight relative to 1 part by weight of the active ingredient.
10. The method according to claim 9, wherein the effective ingredient solution is used in an amount of 0.1 to 5 parts by volume with respect to 1 part by volume of the carrier solution in step c.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596650A (en) * | 2004-07-28 | 2005-03-23 | 吴成奎 | Preparation method of water soluble compound natural insecticide |
| US20150320036A1 (en) * | 2013-01-25 | 2015-11-12 | Fundação Universidade Federal De São Carlos | Process for obtaining biopolymeric nanoparticles containing azadirachta indica a. juss. (neem.) oil and extracts, biopolymeric nanoparticles, and powder microparticles |
| CN107279174A (en) * | 2016-07-25 | 2017-10-24 | 中国农业科学院植物保护研究所 | A kind of preparation method of gamma cyhalothrin nano pesticide |
-
2020
- 2020-08-04 CN CN202010774635.2A patent/CN111903694A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596650A (en) * | 2004-07-28 | 2005-03-23 | 吴成奎 | Preparation method of water soluble compound natural insecticide |
| US20150320036A1 (en) * | 2013-01-25 | 2015-11-12 | Fundação Universidade Federal De São Carlos | Process for obtaining biopolymeric nanoparticles containing azadirachta indica a. juss. (neem.) oil and extracts, biopolymeric nanoparticles, and powder microparticles |
| CN107279174A (en) * | 2016-07-25 | 2017-10-24 | 中国农业科学院植物保护研究所 | A kind of preparation method of gamma cyhalothrin nano pesticide |
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Application publication date: 20201110 |
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