CN111896350B - Top cover plate assembly and biological sample processing equipment - Google Patents
Top cover plate assembly and biological sample processing equipment Download PDFInfo
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- CN111896350B CN111896350B CN202010845223.3A CN202010845223A CN111896350B CN 111896350 B CN111896350 B CN 111896350B CN 202010845223 A CN202010845223 A CN 202010845223A CN 111896350 B CN111896350 B CN 111896350B
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- cover plate
- top cover
- hole
- pressing
- reagent needle
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
Abstract
The invention provides a top cover plate assembly and biological sample processing equipment, wherein the top cover plate assembly comprises: the top cover plate is used for loading a tray for placing a glass slide and a liquid cover film, and a reagent needle through hole for a reagent needle to penetrate through is formed in the top cover plate; the pressing unit is arranged on the top cover plate and used for pressing the liquid covering film which is moved in place downwards to enable the liquid covering film to be in close contact with the glass slide; wherein, the compressing unit includes: the fixing main body is fixed on the top cover plate, and an avoidance structure which corresponds to the reagent needle through hole and is used for avoiding the reagent needle is arranged on the fixing main body; the pressing piece is movably mounted on the fixed main body through the elastic piece so as to elastically press the liquid cover film. The pressing unit is arranged to enable the liquid covering film to be in close contact with the glass slide, so that the evaporation of the reagent is reduced, the moisturizing effect of the biological sample is guaranteed to the maximum extent, and the treatment effect of the biological sample is further guaranteed. In addition, the avoiding structure can avoid the reagent needle, so that the liquid cover film is compacted, and the addition of the reagent is not influenced.
Description
Technical Field
The invention relates to the technical field of biological sample processing, in particular to a top cover plate assembly and biological sample processing equipment.
Background
When a biological sample is processed, the biological sample needs to be placed on a glass slide, a very thin reaction cavity is formed by matching a liquid cover film and the glass slide, and reaction liquid is added into one end of the reaction cavity to enable the biological sample to fully react with the reaction liquid.
For example, the invention discloses a sample smear processing device (i.e. a biological sample processing device) disclosed in the chinese invention patent application with application publication No. CN104089808A, which comprises two cam brackets, wherein a heating module mounting seat is installed on the upper part of each cam bracket, and a plurality of heating modules are arranged on the heating module mounting seat. Heating module mount pad upper portion is provided with sample equipment carrier, and the tray has been placed in inserting in the sample equipment carrier, has placed a plurality of slide glass on the tray side by side, has placed the apron on the carrier (liquid tectorial membrane promptly), and liquid tectorial membrane rear end is equipped with joint portion, is provided with on the heating module mount pad and carries out lateral shifting's smear actuating mechanism (the push-and-pull board promptly) with the cam cooperation, and the joint portion of liquid tectorial membrane is connected with the jack catch cooperation of push-and-pull board.
The sample assembly carrier comprises a top cover plate and moving frames arranged on two sides of the top cover plate, the tray is inserted into the top cover plate, the moving frames are movably arranged on the cam bracket in a vertical guiding mode, a first buffer wheel is arranged on the moving frames, the first buffer wheel is matched with the working face of the cam, the working face of the cam comprises a first working face and a second working face, the curvature of the first working face is gradually reduced from a starting point to a terminal point, and the second working face is an arc face with the same curvature.
When the glass slide heating device works, the cam rotates to enable the first working surface to press the first buffer wheel, the moving frame moves downwards, the top cover plate and the tray on the top cover plate move downwards until the cam rotates the first working surface, and at the moment, the glass slide on the tray is just placed on the heating module. The cam continues to rotate, the first buffer wheel is in contact with the second working surface, downward pressure on the moving frame is kept, at the moment, the second buffer wheel on the cam starts to enter the first positioning groove on the push-pull plate and drives the push-pull plate to move transversely, the clamping jaws drive the liquid cover film to move back and forth, the liquid cover film is switched between an open state and a closed state, the liquid cover film is juxtaposed with the glass slide when in the closed state and covers the biological sample on the glass slide, and at the moment, a reaction cavity is formed between the liquid cover film and the glass slide. Then, the reagent can be added from the inlet of the reaction cavity by using the reagent adding needle, and reagent needle through holes are formed in the positions, corresponding to the heating modules, on the top cover plate, so that the reagent can be conveniently added.
Above-mentioned biological sample treatment facility is when using, because the effect of heating module, biological sample and reagent high temperature on the slide are hatched, and although there is liquid tectorial membrane lid on the slide, the reagent still can evaporate under the high temperature, especially under the not tight condition of liquid tectorial membrane lid, the reagent evaporation can be more serious, can't guarantee biological sample's moisturizing effect, and then influence treatment effect.
Disclosure of Invention
The invention aims to provide a top cover plate assembly which can compress a liquid cover film to enable the liquid cover film to be in close contact with a glass slide so as to reduce reagent evaporation; it is also an object of the present invention to provide a biological specimen processing apparatus capable of compressing a liquid cover film to bring the liquid cover film into intimate contact with a slide glass to reduce evaporation of reagents.
In order to achieve the purpose, the top cover plate assembly adopts the following technical scheme:
a roof deck assembly comprising:
the top cover plate is used for loading a tray for placing a glass slide and a liquid cover film, and a reagent needle through hole for a reagent needle to penetrate through is formed in the top cover plate;
the pressing unit is arranged on the top cover plate and used for pressing the liquid covering film which is moved in place downwards to enable the liquid covering film to be in close contact with the glass slide;
wherein, the compressing unit includes:
the fixing main body is fixed on the top cover plate, and an avoidance structure which corresponds to the reagent needle through hole and is used for avoiding the reagent needle is arranged on the fixing main body;
the pressing piece is movably mounted on the fixed main body through the elastic piece so as to elastically press the liquid cover film.
The beneficial effects of the above technical scheme are that: because the top cover plate assembly comprises a pressing unit arranged on the top cover plate, the pressing unit comprises a fixed main body and a pressing piece movably arranged on the fixed main body through an elastic piece, so that the pressing piece can elastically press the liquid covering film, the liquid covering film which is moved in place is downwards pressed, the liquid covering film is in close contact with the glass slide, the evaporation of a reagent is reduced, the moisturizing effect of the biological sample is ensured to the maximum extent, and the treatment effect of the biological sample is further ensured. In addition, due to the fact that the avoidance structure is arranged on the fixing main body and corresponds to the reagent needle through hole in the top cover plate, the reagent needle can be avoided, and the liquid cover film is compressed tightly, and meanwhile the reagent is not influenced to be added.
Furthermore, in order to facilitate the design and manufacture of the fixing main body and facilitate the formation of the avoiding structure, the fixing main body is n-shaped and comprises two side walls and a connecting wall connected between the two side walls, and the avoiding structure is formed at intervals between the two side walls.
Further, for the convenience of fixing the fixed main body on the top cover plate, the end parts of the two side walls are provided with clamping hooks, the connecting wall is provided with elastic claws, the top cover plate is provided with clamping grooves matched with the clamping hooks, the top cover plate is further provided with clamping holes matched with the elastic claws, and the fixed main body is connected below the top cover plate through the clamping hooks and the elastic claws in a clamping mode.
Further, for the convenience of the setting of trip, the cooperation of trip and draw-in groove and the installation of fixed main part, the trip on the both sides wall is including carrying on the back the first extension section that extends, the second extension section that links to each other with first extension section and upwards extends, the third extension section that links to each other with the second extension section and extends towards the connecting wall, the reagent needle is perforated to the bar hole, still is provided with the mounting hole that communicates so that the installation of fixed main part is perforated to the reagent needle on the lamina tecti, and the width of mounting hole is greater than the fenestrate width of reagent needle, the draw-in groove sets up on the pore wall of mounting hole.
Furthermore, for the convenience of manufacturing, conveniently fix a position and install fixed main part simultaneously, the bullet claw sets up in the inboard of connecting the wall, still is provided with the reference column on the connecting wall, still is provided with on the lamina tecti with reference column complex locating hole.
Furthermore, in order to avoid the bullet claw to deviate from, guarantee the connection effect between bullet claw and the lamina tecti, the lamina tecti subassembly is still including being arranged in inserting the chock in the card hole after the bullet claw passes the card hole.
Furthermore, in order to facilitate the arrangement of the elastic part and the installation of the pressing part, two side walls are provided with cylinders, the elastic part is a spring installed in the cylinder, one end of the cylinder is provided with a cylinder cover, the pressing part is a pressing column movably assembled at the other end of the cylinder, one end of the spring is pressed on the cylinder cover, and the other end of the spring is pressed on the pressing column.
Furthermore, in order to facilitate manufacturing, the fixing main body and the cylinder body are integrally formed by injection molding.
Furthermore, in order to reduce the jacking friction force and facilitate the movement of the hydraulic cover film, the end part of the pressing piece for jacking the hydraulic cover film is provided with a spherical surface.
In order to achieve the purpose, the following technical scheme is adopted for the biological sample treatment in the invention:
a biological sample processing device comprising a moving frame and a top cover plate assembly mounted on the moving frame, the top cover plate assembly comprising:
the top cover plate is used for loading a tray for placing a glass slide and a liquid cover film, and a reagent needle through hole for a reagent needle to penetrate through is formed in the top cover plate;
the pressing unit is arranged on the top cover plate and used for pressing the liquid covering film which is moved in place downwards to enable the liquid covering film to be in close contact with the glass slide;
wherein, the compressing unit includes:
the fixing main body is fixed on the top cover plate, and an avoidance structure which corresponds to the reagent needle through hole and is used for avoiding the reagent needle is arranged on the fixing main body;
the pressing piece is movably mounted on the fixed main body through the elastic piece so as to elastically press the liquid cover film.
The beneficial effects of the above technical scheme are that: because the top cover plate assembly comprises a pressing unit arranged on the top cover plate, the pressing unit comprises a fixed main body and a pressing piece movably arranged on the fixed main body through an elastic piece, so that the pressing piece can elastically press the liquid covering film, the liquid covering film which is moved in place is downwards pressed, the liquid covering film is in close contact with the glass slide, the evaporation of a reagent is reduced, the moisturizing effect of the biological sample is ensured to the maximum extent, and the treatment effect of the biological sample is further ensured. In addition, due to the fact that the avoidance structure is arranged on the fixing main body and corresponds to the reagent needle through hole in the top cover plate, the reagent needle can be avoided, and the liquid cover film is compressed tightly, and meanwhile the reagent is not influenced to be added.
Furthermore, in order to facilitate the design and manufacture of the fixing main body and facilitate the formation of the avoiding structure, the fixing main body is n-shaped and comprises two side walls and a connecting wall connected between the two side walls, and the avoiding structure is formed at intervals between the two side walls.
Further, for the convenience of fixing the fixed main body on the top cover plate, the end parts of the two side walls are provided with clamping hooks, the connecting wall is provided with elastic claws, the top cover plate is provided with clamping grooves matched with the clamping hooks, the top cover plate is further provided with clamping holes matched with the elastic claws, and the fixed main body is connected below the top cover plate through the clamping hooks and the elastic claws in a clamping mode.
Further, for the convenience of the setting of trip, the cooperation of trip and draw-in groove and the installation of fixed main part, the trip on the both sides wall is including carrying on the back the first extension section that extends, the second extension section that links to each other with first extension section and upwards extends, the third extension section that links to each other with the second extension section and extends towards the connecting wall, the reagent needle is perforated to the bar hole, still is provided with the mounting hole that communicates so that the installation of fixed main part is perforated to the reagent needle on the lamina tecti, and the width of mounting hole is greater than the fenestrate width of reagent needle, the draw-in groove sets up on the pore wall of mounting hole.
Furthermore, for the convenience of manufacturing, conveniently fix a position and install fixed main part simultaneously, the bullet claw sets up in the inboard of connecting the wall, still is provided with the reference column on the connecting wall, still is provided with on the lamina tecti with reference column complex locating hole.
Furthermore, in order to avoid the bullet claw to deviate from, guarantee the connection effect between bullet claw and the lamina tecti, the lamina tecti subassembly is still including being arranged in inserting the chock in the card hole after the bullet claw passes the card hole.
Furthermore, in order to facilitate the arrangement of the elastic part and the installation of the pressing part, two side walls are provided with cylinders, the elastic part is a spring installed in the cylinder, one end of the cylinder is provided with a cylinder cover, the pressing part is a pressing column movably assembled at the other end of the cylinder, one end of the spring is pressed on the cylinder cover, and the other end of the spring is pressed on the pressing column.
Furthermore, in order to facilitate manufacturing, the fixing main body and the cylinder body are integrally formed by injection molding.
Furthermore, in order to reduce the jacking friction force and facilitate the movement of the hydraulic cover film, the end part of the pressing piece for jacking the hydraulic cover film is provided with a spherical surface.
Drawings
FIG. 1 is a perspective view of a biological specimen processing device of the present invention from one perspective (with the top cover plate assembly in an open position);
FIG. 2 is a perspective view of another perspective of the biological specimen processing device of the present invention (with the top closure assembly in a closed position);
FIG. 3 is a perspective view of one perspective of the top deck assembly of FIGS. 1 and 2;
FIG. 4 is a side view of the top deck assembly of FIGS. 1 and 2;
FIG. 5 is a perspective view of another perspective of the top deck assembly of FIGS. 1 and 2;
FIG. 6 is an exploded view of FIG. 5;
FIG. 7 is a perspective view of a compression unit in the top deck assembly (including a partially exploded structure);
FIG. 8 is a side view of the compression unit in the top deck assembly;
FIG. 9 is a combination view of the cam, moving frame and cam actuation mechanism of FIGS. 1 and 2;
FIG. 10 is a block diagram of the assembly of FIGS. 1 and 2 with the top cover plate removed;
fig. 11 is a structural view of the push-pull plate of fig. 1, 2 and 10.
In the figure: 1-glass slide; 2-covering the membrane with liquid; 3-heating the module; 4-reagent needle; 5-a stopper; 10-a top cover plate; 11-a cover plate body; 12-front bending part; 13-back bending part; 14-a pin shaft; 15-reagent needle perforation; 16-mounting holes; 17-a hole; 18-positioning holes; 19-a card slot; 20-a compacting unit; 21-a stationary body; 22-cylinder body; 23-pressing the column; 24-a latch; 25-trip; 26-a positioning post; 27-cartridge cover; 28-a spring; 30-a base; 40-cam; 41-a first working surface; 42-a second working surface; 43-a limit groove; 44-a second follower wheel; 50-a motion frame; 51-a first follower wheel; 60-a push-pull plate; 61-claw; 62-a drive plate; 70-heating module mounting seat; 80-a drive motor; 81-worm; 90-a drive shaft; 91-worm wheel.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the detailed description and specific examples, while indicating the preferred embodiment of the invention, are intended for purposes of illustration only and are not intended to limit the scope of the invention. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations.
Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without making any creative effort, shall fall within the protection scope of the present invention.
It is noted that relational terms such as "first" and "second," and the like, may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in a process, method, article, or apparatus that comprises the element.
The features and properties of the present invention are described in further detail below with reference to examples.
One embodiment of the biological sample processing apparatus of the present invention is shown in fig. 1 and 2, and includes a left base 30 and a right base 30, a cam 40 rotatably mounted on the bases 30, a heating module mounting seat 70 provided on the upper portion of the bases 30, and a plurality of heating modules 3 provided on the heating module mounting seat 70. The upper part of the heating module mounting seat 70 is provided with a sample assembling carrier which comprises a left moving frame 50 and a right moving frame 50 and a top cover plate assembly arranged on the moving frames 50, and the moving frames 50 are guided and movably arranged on the base 30 along the up-down direction. The heating module mounting base 70 is provided with a push-pull plate 60 which is moved laterally in cooperation with the cam 40.
The top cover plate assembly comprises a top cover plate 10 and a pressing unit 20 installed on the top cover plate 10, wherein the top cover plate 10 is used for loading trays (shown in the figures), before the trays are loaded, a glass slide 1 and a liquid cover film 2 are placed on the trays, after the trays are loaded, along with downward movement of the top cover plate, the glass slide 1 descends onto a heating module 3 to be in contact with the heating module 3, and the liquid cover film 2 covers the glass slide 1, which is the same as that in the prior art.
As shown in fig. 3, 4, 5 and 6, the top cover plate 10 is hinged on the moving frame 50 through a pin 14, the top cover plate 10 includes a cover plate body 11 with a length extending along the left-right direction, a front bending portion 12 is arranged at the front end of the cover plate body 11, a rear bending portion 13 is arranged at the rear end of the cover plate body 11, the front bending portion 12 and the rear bending portion 13 are both located below the cover plate body 11 and are both L-shaped, and a support track for inserting the tray is formed. Wherein, be provided with a plurality of fretwork holes on the portion 13 of bending after, fretwork hole and heating module 3 one-to-one make things convenient for push-and-pull plate 60 to be connected with each liquid cover membrane 2 cooperation through the fretwork hole.
As shown in fig. 7 and 8, the pressing unit 20 includes an n-shaped fixing body 21, the fixing body 21 includes two side walls and a connecting wall connected between the two side walls, the end portions of the two side walls are respectively provided with a hook 25, and the hooks 25 on the two side walls include a first extending section extending away from each other, a second extending section extending upward from the first extending section, and a third extending section extending toward the connecting wall from the second extending section.
As shown in fig. 2, 3, 5 and 6, the cover plate body 11 is provided with a reagent needle penetration hole 15 through which the reagent needle 4 penetrates, and the reagent needle penetration hole 15 is a strip-shaped hole whose length extends in the front-rear direction. Still be provided with the mounting hole 16 of fixed main part 21 of easy to assemble on the apron body 11, mounting hole 16 be located the front side of the reagent needle perforation 15 and with the perforation 15 intercommunication of reagent needle, the width of mounting hole 16 is greater than the width of the reagent needle perforation 15, be provided with draw-in groove 19 on the pore wall of the perforation 15 of reagent needle of mounting hole 16, the notch of draw-in groove 19 sets up forward, draw-in groove 19 has two, correspond the cooperation with two trip 25 on the fixed main part 21.
The connecting wall of the fixing main body 21 is integrally provided with a downwardly extending elastic claw 24, the elastic claw 24 is positioned on the inner side of the connecting wall (namely the front side of the connecting wall), the cover plate body 11 is provided with a clamping hole 17 matched with the elastic claw 24, the clamping hole 17 is positioned on the rear side of the reagent needle perforation 15, and after the elastic claw 24 passes through the clamping hole 17, the tail end of the elastic claw is hooked on the top surface of the cover plate body 11. The hook 25 is clamped in the clamping groove 19, the third extending section of the hook 25 is hooked on the top surface of the cover plate body 11, and the fixing main body 21 is clamped below the top cover plate through the hook 25 on the front side and the elastic claw 24 on the rear side.
In order to facilitate the installation of the fixing main body 21, a positioning post 26 extending downward is further disposed on the connecting wall of the fixing main body 21, a positioning hole 18 matched with the positioning post 26 is disposed on the cover plate body 11, and the positioning hole 18 is located at the rear side of the clamping hole 17. When the fixing main body 21 is installed, the hook 25 at the front end of the fixing main body 21 penetrates into the installation hole 16, the fixing main body 21 is tightly attached to the bottom surface of the cover plate body 11, the fixing main body 21 is pulled backwards until the hook 25 is clamped into the clamping groove 19, the elastic claw 24 penetrates through the clamping hole 17 and the positioning column 26 and is clamped into the positioning hole 18, the positioning column 26 is used for positioning the fixing main body 21, and the hook 25 is prevented from being accidentally separated from the clamping groove 19.
In order to achieve a better connection effect and avoid the fixed main body 21 from falling off from the cover plate body 11, the clamping hole 17 is slightly larger, and after the elastic claw 24 penetrates through the clamping hole 17, the plug block 5 is plugged into the clamping hole 17, so that the elastic claw 24 is limited, and the elastic claw 24 is prevented from being separated from the clamping hole 17 due to the elasticity of the elastic claw 24. After the fixing main body 21 is fixed on the cover plate body 11, an avoiding structure for avoiding the reagent needle is formed at the interval between the two side walls, and the avoiding structure corresponds to the reagent needle through hole 15 up and down.
As shown in fig. 7, the two side walls of the fixing body 21 are provided with the cylindrical bodies 22, and the fixing body 21, the hooks 25, the elastic claws 24, the positioning posts 26 and the cylindrical bodies 22 are integrally injection-molded for convenience of manufacture. The upper end of the cylinder 22 is fixedly provided with a cylinder cover 27, and the cylinder cover 27 is in interference fit with the inner hole wall of the cylinder 22. The lower end of the cylinder 22 is movably assembled with a compression column 23, the compression column 23 is provided with a stopping step, and the inner wall of the cylinder 22 is provided with a corresponding stopping step to limit the compression column 23 from being separated from the cylinder 22. A spring 28 is arranged in the cylinder body 22, one end of the spring 28 is pressed on the cylinder cover 27, and the other end is pressed on the compression column 23. During assembly, the compression leg 23 is inserted through the barrel 22 from the top down, the spring 28 is loaded in the barrel 22, and the barrel cover 27 is finally inserted.
The two cylinder bodies 22 provided on each side wall of the fixing body 21, that is, the four press pillars 23 in total, and as shown in fig. 4, the two latter press pillars are not at the same height as the two former press pillars, so as to accommodate the obliquely arranged heating module. The pressing column 23 is used for elastically pressing the liquid covering film covering the upper part of the glass slide downwards, and in order to reduce friction force and facilitate the movement of the liquid covering film, the end part of the pressing column 23 used for pressing the liquid covering film is provided with a spherical surface, namely the lower end of the pressing column 23 is provided with the spherical surface.
As shown in fig. 9, the biological sample processing apparatus includes a cam driving mechanism for driving the cams 40 to rotate, the cam driving mechanism includes a driving motor 80 and a transmission shaft 90 disposed between the two cams 40, a worm 81 is disposed at an output end of the driving motor 80, and a worm wheel 91 engaged with the worm 81 is mounted on the transmission shaft 90.
The cam 40 is provided with a limit groove 43, a first working surface 41 connected with the limit groove 43, and a second working surface 42 connected with the first working surface 41, wherein the curvature of the first working surface 41 is gradually reduced from a starting point to an end point, and the second working surface 42 is an arc surface with the same curvature. The moving frame 50 is provided with a first follower wheel 51, and the first follower wheel 51 cooperates with the limiting groove 43, the first working surface 41 and the second working surface 42.
As shown in fig. 10 and 11, the push-pull plate 60 includes a claw 61 corresponding to each liquid covering film 2, the claw 61 is provided with a U-shaped groove with an upward notch, and the clamping portion of the liquid covering film 2 is clamped into the U-shaped groove of the claw 61. The push-pull plate 60 further includes a drive plate 62, the drive plate 62 having a downwardly facing U-shaped slot formed therein for engaging the second follower wheel 44 mounted on the cam 40.
When the biological sample processing device works, the main working process of the biological sample processing device is the same as that of the prior art, a tray on which a glass slide and a liquid cover film are placed is arranged on a top cover plate, then a driving motor 80 is started, a cam 40 rotates under the action of a worm and gear transmission mechanism, a first follow-up wheel 51 on a moving frame 50 is separated from a limiting groove 43 and is contacted with a first working surface 41, the first working surface 41 presses the first follow-up wheel 51 downwards along with the rotation of the cam 40, the moving frame 50 drives a top cover plate assembly to move downwards, the glass slide 1 is firstly placed on a heating module 3 in the process that the cam 40 finishes rotating the first working surface 41, the liquid cover film 2 is supported above the glass slide 1, the liquid cover film 2 and the glass slide 1 move downwards to be in place, and then a pressing unit elastically presses the liquid cover film 2 to enable the liquid cover film 2 to be in close contact with the glass slide 1. When the cam continues to rotate, the second working surface 42 contacts with the first follower wheel 51, and the second working surface 42 is an arc surface, so that the moving frame does not move downwards any more, and the pressing unit is kept pressing the liquid covering film.
When the cam 40 continues to rotate, the second follower wheel 44 on the cam 40 enters the U-shaped groove on the transmission plate 62, the second follower wheel 44 drives the push-pull plate 60 to move back and forth, the clamping jaw 61 drives the liquid covering film 2 to move back and forth, and the liquid covering film 2 completely or partially covers the slide glass 1, so that the position of the liquid covering film is adjusted, the position for adding the reagent is the front end of the liquid covering film, namely the push-pull plate pushes or pulls the liquid covering film, the position for adding the reagent is changed, the consumption of the reagent can be adjusted according to the size of a biological sample on the slide glass, the consumption of the reagent is reduced, and the cost is saved.
The pressing unit elastically presses the liquid covering film 2, and the pressing end is set to be a spherical surface, so that the smooth movement of the liquid covering film is not influenced. Because the liquid covering film 2 is always in close contact with the glass slide 1, the evaporation of the reagent can be reduced, the moisturizing effect of the biological sample is ensured to the maximum extent, and the treatment effect of the biological sample is further ensured. In addition, the avoidance structure formed by the shape of the fixed main body corresponds to the reagent needle perforation on the top cover plate, and the reagent needle can be avoided, so that the liquid cover film is compacted, and the addition of the reagent is not influenced.
In other embodiments of the biological sample processing device, the end of the constriction member for the top-pressure hydraulic cover membrane may not be provided with a spherical surface, but rather a generally cylindrical or curved transition.
In other embodiments of the biological sample processing apparatus, the barrel, the hook, the elastic claw and the positioning column may be fixed to the fixing body by bonding, instead of being integrally injection-molded with the fixing body, or may be welded to the fixing body when the pressing unit is made of metal.
In other embodiments of the biological sample processing apparatus, the pressing member may be a pressing rod hinged to the fixing body, and a torsion spring is mounted on the pressing rod, and the torsion spring constitutes an elastic member to move the pressing rod to elastically press the cover membrane.
In other embodiments of the biological sample processing device, no stop block may be provided.
In other embodiments of the biological sample processing apparatus, the positioning column may not be provided, and the connection between the fixing body and the top cover plate may be realized only by the elastic claw and the hook.
In other embodiments of the biological sample processing device, the hook may also be L-shaped, comprising only two extensions.
In other embodiments of the biological sample processing apparatus, the fixing body may not have a hook or a spring claw, for example, a threaded hole may be formed in the fixing body, and a bolt is threaded through the top cover plate and is connected with the fixing body, so as to fix the fixing body and the top cover plate.
In other embodiments of the biological sample processing apparatus, the fixing body may also be a rectangular frame structure, and at this time, the rectangular hole formed by the fixing body is an avoiding structure for avoiding the reagent needle.
The embodiment of the top cover plate assembly in the invention is as follows: the specific structure of the top cover plate assembly is the same as that of the top cover plate assembly in the above-described embodiment of the biological sample processing device, and will not be repeated here.
The above description is only a preferred embodiment of the present invention, and not intended to limit the present invention, the scope of the present invention is defined by the appended claims, and all structural changes that can be made by using the contents of the description and the drawings of the present invention are intended to be embraced therein.
Claims (7)
1. A roof deck assembly, comprising:
the top cover plate is used for loading a tray for placing a glass slide and a liquid cover film, and a reagent needle through hole for a reagent needle to penetrate through is formed in the top cover plate;
the pressing unit is arranged on the top cover plate and used for pressing the liquid covering film which is moved in place downwards to enable the liquid covering film to be in close contact with the glass slide;
wherein, the compressing unit includes:
the fixing main body is fixed on the top cover plate, and an avoidance structure which corresponds to the reagent needle through hole and is used for avoiding the reagent needle is arranged on the fixing main body;
the pressing piece is movably arranged on the fixed main body through an elastic piece so as to elastically press the liquid cover film;
the fixing main body is n-shaped and comprises two side walls and a connecting wall connected between the two side walls, and the avoidance structure is formed at intervals between the two side walls;
the end parts of the two side walls are provided with clamping hooks, the connecting wall is provided with elastic claws, the top cover plate is provided with clamping grooves matched with the clamping hooks, the top cover plate is also provided with clamping holes matched with the elastic claws, and the fixed main body is clamped below the top cover plate through the clamping hooks and the elastic claws;
the two side walls are provided with a barrel body, the elastic part is a spring arranged in the barrel body, one end of the barrel body is provided with a barrel cover, the pressing part is a pressing column movably assembled at the other end of the barrel body, one end of the spring is pressed on the barrel cover, and the other end of the spring is pressed on the pressing column.
2. The top cover plate assembly of claim 1, wherein the hooks on the two side walls comprise a first extension section extending away from each other, a second extension section extending upward from the first extension section, and a third extension section extending toward the connecting wall from the second extension section, the reagent needle through hole is a strip-shaped hole, the top cover plate is further provided with a mounting hole communicating with the reagent needle through hole for mounting the fixing body, the mounting hole has a width larger than that of the reagent needle through hole, and the locking groove is formed on a wall of the mounting hole.
3. The top cover plate assembly as claimed in claim 1 or 2, wherein the elastic claw is disposed at an inner side of the connecting wall, the connecting wall is further provided with a positioning post, and the top cover plate is further provided with a positioning hole matched with the positioning post.
4. The top cover plate assembly of claim 1 or 2, further comprising a plug for plugging the catch into the catch hole after the catch passes through the catch hole.
5. The roof deck assembly of claim 1 or 2, wherein the stationary body and the barrel are integrally injection molded.
6. The top cover plate assembly of claim 1 or 2 wherein the end of the pressing member for pressing the hydraulic head membrane is provided with a spherical surface.
7. A biological specimen processing apparatus comprising a moving frame and a top cover plate assembly mounted on the moving frame, the top cover plate assembly being the same as the top cover plate assembly of any one of claims 1 to 6.
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| CN202010845223.3A CN111896350B (en) | 2020-08-20 | 2020-08-20 | Top cover plate assembly and biological sample processing equipment |
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| CN111896350B true CN111896350B (en) | 2021-09-07 |
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| CN114152496A (en) * | 2021-12-31 | 2022-03-08 | 河南赛诺特生物技术有限公司 | Automatic immunohistochemical dyeing machine |
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| DE102011007324A1 (en) * | 2011-04-13 | 2012-10-18 | Carl Zeiss Microlmaging Gmbh | Holder for holding elongate, plate-like object carrier at automated microscope for sampling sample preparation, has counterstop and stop fastening end of carrier at support surface, where another end of carrier freely projects at holder |
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| CN111896350A (en) | 2020-11-06 |
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