CN111887895A - Saliva collection device with disease enrichment adsorption structure - Google Patents
Saliva collection device with disease enrichment adsorption structure Download PDFInfo
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- CN111887895A CN111887895A CN202010588003.7A CN202010588003A CN111887895A CN 111887895 A CN111887895 A CN 111887895A CN 202010588003 A CN202010588003 A CN 202010588003A CN 111887895 A CN111887895 A CN 111887895A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0051—Devices for taking samples of body liquids for taking saliva or sputum samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/405—Concentrating samples by adsorption or absorption
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B2010/009—Various features of diagnostic instruments
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The invention provides a saliva collecting device with a disease enrichment adsorption structure, which comprises a sampler and a sample storage bottle; the sampler comprises a hollow package, a resin adsorption module and a negative pressure control device; the package is provided with a collection port and a negative pressure port; the resin adsorption module is arranged in the package and is arranged at one end of the package close to the acquisition port; the negative pressure control device is detachably connected to a negative pressure port of the package; a sample preservation solution is preset in the sample storage bottle; the sampler is inserted in the sample storage bottle after sampling to provide a saliva collection device which realizes effective adsorption and enrichment aiming at viruses and realizes short-term storage of the viruses.
Description
Technical Field
The invention relates to the technical field of biological preservation, in particular to a saliva collecting device with a disease enrichment adsorption structure.
Background
Saliva is an important biological fluid and is one of the detection specimens commonly used in biomedical research and clinical practice. Under normal physiological conditions, saliva contains not only oral epithelial cells exfoliated from the oral cavity of a donor, but also a variety of proteins/enzyme molecules secreted from salivary glands, extracellular vesicles/exosomes, microbial cells of normal flora of minute nucleic acid molecules, and the like. In disease states such as viral or bacterial infections, viral particles, bacterial or fungal pathogen cells may also be present. Studies have shown that saliva samples are more stable and reliable for detection of viral nucleic acids following respiratory virus infection than samples collected by other methods such as nasopharyngeal swabs. The existing various devices for collecting and sampling saliva are simple and direct, do not adsorb and enrich biological components to be detected, have no non-toxic built-in mark for successful sampling, and have no protective performance for related biological components; the sampling operation must also be performed by trained professionals. Therefore, the existing saliva sampling device cannot be completed by the ordinary people, cannot be used for short-term preservation of samples, and cannot be used for remote transfer of saliva samples.
Disclosure of Invention
The invention aims to provide a saliva collecting device which can realize effective adsorption and enrichment aiming at viruses and realize short-term storage of the viruses.
In order to achieve the purpose, the invention provides a saliva collecting device with a disease enrichment adsorption structure, which comprises a sampler and a sample storage bottle;
the sampler comprises a hollow package, a resin adsorption module and a negative pressure control device; the package is provided with a collection port and a negative pressure port; the resin adsorption module is arranged in the package and is arranged at one end, close to the acquisition port, in the package; the negative pressure control device is detachably connected to the negative pressure port of the package;
a sample preservation solution is preset in the sample storage bottle; and the sampler is inserted into the sample storage bottle after sampling.
Preferably, the package is a hollow glass package, the package is a columnar structure, the head end of the package is the collecting port, and the tail end of the package is the negative pressure port.
Preferably, the resin adsorption module is a mixture of ion exchange resin having strong adsorption force to viruses and bacteria and chitosan or dextran particles.
Preferably, the resin adsorption module is a mixture of porous ion exchange resin, sialylated ion exchange resin or/and chitosan;
preferably, the resin adsorption module is cellulose, dextran or/and sepharose.
Preferably, the resin adsorption modules are arranged in the package in a cylindrical, square-cylinder, sheet-like or beaded structure.
Preferably, the negative pressure device is a rubber suction ball which is sleeved on the negative pressure port of the sample storage bottle.
Preferably, the sample storage bottle is a glass bottle, and a bottle cap is screwed and fixed at the bottle mouth of the glass bottle;
the sample preservation solution is a physiological buffer solution, and the physiological buffer solution comprises serum-free cell culture solution, Hank's buffer solution, PBS phosphate buffer solution, TRIS buffer solution or physiological saline; the physiological buffer solution is also added with phenol red indicator and composite broad spectrum antibiotics, including penicillin, streptomycin and amphotericin B.
Preferably, still include the filter paper strip, the filter paper strip is arranged in the packing, the filter paper strip with the resin adsorption module is connected, the printing has wet seal marking line on the filter paper strip, wet seal marking line adopts and meets water color development ink and carves.
Compared with the prior art, the invention has the advantages that: according to the saliva collection device, the resin adsorption module is arranged in the sampler, so that the collection efficiency of pathogens and other biological components to be detected can be improved, and the concentration of the extracted pathogens and other biological components in the sample can be improved.
Whether the sampling is enough can be observed and judged through the wet mark on the filter paper strip in the sampler in the adoption process, guarantee the precision of sampling, improve sampling efficiency.
The operation is simple, and ordinary adults can operate and realize the operation in real time according to the illustration without professional training;
the sampler and the sample storage bottle are combined for use, so that the samples can be conveniently stored at normal room temperature for a short time, and the sampler is suitable for remote delivery, is convenient for sample transportation and ensures the sampling quality.
Drawings
FIG. 1 is a schematic diagram of a saliva collection device according to an embodiment of the invention;
FIG. 2 is a schematic diagram of a sampler according to an embodiment of the present invention;
FIG. 3 is a flow chart illustrating the operation of the sampler and the sample storage bottle according to the embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be further described below.
As shown in fig. 1, the invention provides a saliva collecting device with a disease enrichment adsorption structure, which comprises a sampler 1 and a sample storage bottle 2;
as shown in fig. 2, the sampler 1 includes a hollow package 4, a resin adsorption module 3, and a negative pressure control device 5; the package 4 is provided with a collection port and a negative pressure port; the resin adsorption module 3 is arranged in the package 4 and is arranged at one end of the package 4 close to the acquisition port; the negative pressure control device 5 is detachably connected with a negative pressure port of the package 4; the filter paper packaging structure is characterized by further comprising a filter paper strip 6, the filter paper strip 6 is arranged in the package 4, the filter paper strip 6 is connected with the resin adsorption module 3, a wet printing mark line 7 is printed on the filter paper strip 6, and the wet printing mark line 7 is engraved by water-encountering color-developing ink.
In this embodiment, the method of using the sampler 1 is as follows: a user operates the negative pressure control device 5 to generate negative pressure inside the package 4, viruses are adsorbed onto the resin adsorption module 3 at the moment, when the adsorption of the resin adsorption module 3 on the viruses is close to saturation, moisture can extend onto the filter paper strip 6 along the resin adsorption module 3, and when the wet printing mark line 7 on the filter paper strip 6 is wetted, the color of the wet printing mark line is changed when the wet printing mark line meets water, that is, the sampler 1 collects a set sufficient amount of saliva samples; wherein the water-color ink has no any damage effect on the sample.
In the embodiment, the resin adsorption module 3 is a mixture of ion exchange resin with strong adsorption force on various viruses and bacteria and chitosan or glucan particles solidified with special virus receptor structures; consists of nontoxic porous ion exchange resin, sialylated ion exchange resin or/and chitosan mixture; the resin adsorption module 3 can also be cellulose, dextran or/and sepharose; the selection can be made according to the requirements of the actual application.
In view of the high affinity properties of ion exchange resins, sialic acid and the surface groups of chitosan molecules for a variety of viral particles, including influenza virus and COVID-19 new coronavirus, the resin adsorption module 3 can capture and bind the viral particles in saliva within the module during sampling, increasing the concentration of viral particles in the collected sample. The affinity capture activity of the adsorption module is also effective against bacterial and fungal microorganisms, exfoliated endothelial cells, and extracellular particles. Thus, the resin adsorption module 3 will improve the efficiency of collection of potential pathogens or other biological components.
In this embodiment, the package 4 is a hollow glass package 4, the package 4 is a cylindrical structure, the head end of the package 4 is a collecting port, and the tail end of the package 4 is a negative pressure port. The observation of the sample collection situation in the package 4 is facilitated.
In the embodiment, the sample storage bottle 2 is a glass bottle 8, a bottle cap 10 is screwed and fixed at the bottle mouth of the glass bottle, and a sealing cover 11 is arranged at the bottle cap 10 and the bottle mouth; a sample preservation solution is preset in the sample storage bottle 2; the sampler 1 is inserted into the sample storage bottle 2 after sampling.
In the practical application process, the sampler 1 can be directly placed in the sample storage bottle 2 after sampling, and the negative pressure control device 5 is taken down for preservation. In this embodiment, negative pressure control device 5 adopts rubber to inhale the ball, rubber inhale the ball cup joint in on the negative pressure mouth of storage sample bottle 2, operating personnel extrudees rubber inhale the ball, can realize the inside negative pressure state of sampler 1 to realize the absorption and the taking out of virus sample. In sample storage bottle 2 is arranged in to sampler 1, extrudees the rubber and inhales the ball simultaneously, with partial saliva sample discharge in the storage bottle, then take off the rubber from the negative pressure mouth of sample sampler 1 and inhale the ball, screw up bottle lid 10, can realize the save of saliva sample safety, then before the sample is sent the laboratory test to, can realize the preservation of sample short time, guarantee the collection quality of sample. After being sent to the laboratory, open bottle lid 10, can directly follow the sample 1 upper end opening part and absorb the sample, easy operation, convenience to safe and greatly reduced the sample by the pollution or the risk of leaking. Aiming at some detection equipment needing a carrier, the sample storage bottle 2 with the preserved sample can be directly matched with the detection equipment to finish detection.
In this embodiment, the sample preservation solution is a physiological buffer solution 9, and the physiological buffer solution 9 includes serum-free cell culture solution, Hank's buffer solution, PBS phosphate buffer solution, TRIS buffer solution, or physiological saline; the physiological buffer solution 9 is also added with phenol red indicator and composite broad spectrum antibiotics, including penicillin, streptomycin and amphotericin B. For the collection of a specific virus sample, such as a COVID-19 new coronavirus sample, the buffer may also be supplemented with the RNase inhibitor, Diacetylpyrocarbonate (DEPC), which helps stabilize the RNA. The antibiotic helps to inhibit the growth of potential microorganisms during short term storage, and the phenol red indicator helps to indicate the presence or absence of a change in pH in the sample buffer during storage.
The above description is only a preferred embodiment of the present invention, and does not limit the present invention in any way. It will be understood by those skilled in the art that various changes, substitutions and alterations can be made herein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (9)
1. A saliva collecting device with a disease enrichment adsorption structure is characterized by comprising a sampler and a sample storage bottle;
the sampler comprises a hollow package, a resin adsorption module and a negative pressure control device; the package is provided with a collection port and a negative pressure port; the resin adsorption module is arranged in the package and is arranged at one end, close to the acquisition port, in the package; the negative pressure control device is detachably connected to the negative pressure port of the package;
a sample preservation solution is preset in the sample storage bottle; and the sampler is inserted into the sample storage bottle after sampling.
2. The saliva collection device with a disease enrichment adsorption structure of claim 1, wherein the package is a hollow glass package, the package is a cylindrical structure, the head end of the package is the collection port, and the tail end of the package is the negative pressure port.
3. The saliva collection device with a disease enrichment adsorption structure of claim 1, wherein the resin adsorption module is a mixture of ion exchange resin and chitosan or dextran particles having strong adsorption force to viruses and bacteria.
4. The saliva collection device with a disease enrichment adsorption structure of claim 3, wherein the resin adsorption module is a porous ion exchange resin, a sialylated ion exchange resin, or/and a mixture of chitosan.
5. The saliva collection device with a disease enrichment adsorption structure of claim 1, wherein the resin adsorption module is cellulose, dextran or/and sepharose.
6. The saliva collection device with a disease enrichment adsorption structure of claim 1, wherein the resin adsorption modules are arranged in the package in a cylinder, a square cylinder, a sheet or a bead-like structure.
7. The saliva collecting device with the disease enrichment adsorption structure as claimed in claim 1, wherein the negative pressure device is a rubber suction ball which is sleeved on the negative pressure port of the sample storage bottle.
8. The saliva collecting device with the disease enrichment adsorption structure as claimed in claim 1, wherein the sample storage bottle is a glass bottle, and a bottle cap is screwed and fixed at the bottle mouth of the glass bottle;
the sample preservation solution is a physiological buffer solution, and the physiological buffer solution comprises serum-free cell culture solution, Hank's buffer solution, PBS phosphate buffer solution, TRIS buffer solution or physiological saline; the physiological buffer solution is also added with phenol red indicator and composite broad spectrum antibiotics, including penicillin, streptomycin and amphotericin B.
9. The saliva collection device with a disease enrichment adsorption structure of claim 1, further comprising a paper filter strip, wherein the paper filter strip is placed in the package and connected with the resin adsorption module, and wet-printed mark lines are printed on the paper filter strip and engraved with water-color ink.
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| CN202010588003.7A CN111887895A (en) | 2020-06-24 | 2020-06-24 | Saliva collection device with disease enrichment adsorption structure |
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| CN202010588003.7A CN111887895A (en) | 2020-06-24 | 2020-06-24 | Saliva collection device with disease enrichment adsorption structure |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114085829A (en) * | 2021-11-18 | 2022-02-25 | 军事科学院军事医学研究院环境医学与作业医学研究所 | Efficient enrichment method for viruses in environmental medium |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2137134Y (en) * | 1992-08-21 | 1993-06-30 | 中国人民解放军第四军医大学第一附属医院 | Negative pressure type tube for taking sample of manure |
| CN101368954A (en) * | 2007-08-16 | 2009-02-18 | 广州百澳诺斯特高新技术有限公司 | Apparatus and method for clinical or non-clinical acquired immuno-deficiency syndrome virus detection by using saliva |
| CN201790838U (en) * | 2010-09-21 | 2011-04-13 | 广州万孚生物技术有限公司 | Saliva collecting and treating device |
| US20120202193A1 (en) * | 2009-09-18 | 2012-08-09 | Hans-Werner Heinrich | Disposable device for storing biological liquids and use thereof to detect materials, particles, and/or cells |
| CN102947687A (en) * | 2010-06-09 | 2013-02-27 | 意大利科潘恩集团公司 | A method for quantitative transfer of analytes |
| EP2689729A1 (en) * | 2012-07-23 | 2014-01-29 | DML - ABLogics Limited | Disposable test device |
| CN204484173U (en) * | 2015-03-12 | 2015-07-22 | 天津市南开医院 | Baby's spittle collector |
| CN108414512A (en) * | 2017-06-09 | 2018-08-17 | 北京中生朗捷生物技术股份有限公司 | Multi-functional sample detecting stick for saliva, DNA sample acquisition and alcohol detection |
| CN208769830U (en) * | 2018-04-23 | 2019-04-23 | 东莞市第五人民医院(东莞市太平人民医院) | A kind of gingival sulcus liquor collecting device |
| CN209315910U (en) * | 2018-03-28 | 2019-08-30 | 中南大学 | A kind of saliva collecting device |
| CN210056080U (en) * | 2019-02-25 | 2020-02-14 | 刘辰 | Accurate oral saliva collection and censorship device |
-
2020
- 2020-06-24 CN CN202010588003.7A patent/CN111887895A/en active Pending
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2137134Y (en) * | 1992-08-21 | 1993-06-30 | 中国人民解放军第四军医大学第一附属医院 | Negative pressure type tube for taking sample of manure |
| CN101368954A (en) * | 2007-08-16 | 2009-02-18 | 广州百澳诺斯特高新技术有限公司 | Apparatus and method for clinical or non-clinical acquired immuno-deficiency syndrome virus detection by using saliva |
| US20120202193A1 (en) * | 2009-09-18 | 2012-08-09 | Hans-Werner Heinrich | Disposable device for storing biological liquids and use thereof to detect materials, particles, and/or cells |
| CN102947687A (en) * | 2010-06-09 | 2013-02-27 | 意大利科潘恩集团公司 | A method for quantitative transfer of analytes |
| CN201790838U (en) * | 2010-09-21 | 2011-04-13 | 广州万孚生物技术有限公司 | Saliva collecting and treating device |
| EP2689729A1 (en) * | 2012-07-23 | 2014-01-29 | DML - ABLogics Limited | Disposable test device |
| CN204484173U (en) * | 2015-03-12 | 2015-07-22 | 天津市南开医院 | Baby's spittle collector |
| CN108414512A (en) * | 2017-06-09 | 2018-08-17 | 北京中生朗捷生物技术股份有限公司 | Multi-functional sample detecting stick for saliva, DNA sample acquisition and alcohol detection |
| CN209315910U (en) * | 2018-03-28 | 2019-08-30 | 中南大学 | A kind of saliva collecting device |
| CN208769830U (en) * | 2018-04-23 | 2019-04-23 | 东莞市第五人民医院(东莞市太平人民医院) | A kind of gingival sulcus liquor collecting device |
| CN210056080U (en) * | 2019-02-25 | 2020-02-14 | 刘辰 | Accurate oral saliva collection and censorship device |
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| CN114085829A (en) * | 2021-11-18 | 2022-02-25 | 军事科学院军事医学研究院环境医学与作业医学研究所 | Efficient enrichment method for viruses in environmental medium |
| CN114085829B (en) * | 2021-11-18 | 2023-08-11 | 军事科学院军事医学研究院环境医学与作业医学研究所 | Efficient enrichment method for viruses in environmental medium |
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