CN111868072A - 类肽化合物及其制备方法、纳米载体以及药物组合物 - Google Patents

类肽化合物及其制备方法、纳米载体以及药物组合物 Download PDF

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CN111868072A
CN111868072A CN201980000007.4A CN201980000007A CN111868072A CN 111868072 A CN111868072 A CN 111868072A CN 201980000007 A CN201980000007 A CN 201980000007A CN 111868072 A CN111868072 A CN 111868072A
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peptoid compound
peptoid
compound
pamam
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CN111868072B (zh
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赵子健
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BOE Technology Group Co Ltd
Beijing BOE Technology Development Co Ltd
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BOE Technology Group Co Ltd
Beijing BOE Technology Development Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

提供一种类肽化合物，包括：半胱氨酸(Cys)亚单位、1,4‑丁二胺(Nlys)亚单位、胡椒基胺亚单位、丙酸胺亚单位和1‑萘胺亚单位，所述类肽化合物对EGFR蛋白具有亲和力和选择性，同时具有药物包载效率，没有毒性。还提供了一种包括所述类肽的纳米载体、药物组合物以及该药物组合物在制备治疗与人表皮生长因子受体1(EGFR)相关的疾病的药物中的用途。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201980000007.4A 2019-01-03 2019-01-03 类肽化合物及其制备方法、纳米载体以及药物组合物 Active CN111868072B (zh)

Applications Claiming Priority (1)

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PCT/CN2019/070261 WO2020140237A1 (zh) 2019-01-03 2019-01-03 类肽化合物及其制备方法、纳米载体以及药物组合物

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CN111868072B CN111868072B (zh) 2023-08-29

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101501065A (zh) * 2005-10-06 2009-08-05 特罗弗根公司 Vegf类似物及使用方法
WO2012125904A1 (en) * 2011-03-17 2012-09-20 The Trustees Of The University Of Pennsylvania Mutation mimicking compounds that bind to the kinase domain of egfr
CN105753940A (zh) * 2016-02-05 2016-07-13 国家纳米科学中心 一种类肽抑制剂、其制备方法及应用
CN106854233A (zh) * 2017-03-03 2017-06-16 国家纳米科学中心 一种类肽及其制备方法和应用
CN106866794A (zh) * 2017-02-15 2017-06-20 国家纳米科学中心 一种类肽及其制备方法和应用
CN108586579A (zh) * 2018-05-11 2018-09-28 京东方科技集团股份有限公司 一种类肽及其衍生物、盐、制备方法和用途
CN108653242A (zh) * 2018-07-03 2018-10-16 京东方科技集团股份有限公司 一种靶向纳米药物载体及其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015175299A1 (en) * 2014-05-12 2015-11-19 University Of Louisiana At Monroe Peptidomimetics for treating her2-overexpressed

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101501065A (zh) * 2005-10-06 2009-08-05 特罗弗根公司 Vegf类似物及使用方法
WO2012125904A1 (en) * 2011-03-17 2012-09-20 The Trustees Of The University Of Pennsylvania Mutation mimicking compounds that bind to the kinase domain of egfr
CN105753940A (zh) * 2016-02-05 2016-07-13 国家纳米科学中心 一种类肽抑制剂、其制备方法及应用
CN106866794A (zh) * 2017-02-15 2017-06-20 国家纳米科学中心 一种类肽及其制备方法和应用
CN106854233A (zh) * 2017-03-03 2017-06-16 国家纳米科学中心 一种类肽及其制备方法和应用
CN108586579A (zh) * 2018-05-11 2018-09-28 京东方科技集团股份有限公司 一种类肽及其衍生物、盐、制备方法和用途
CN108653242A (zh) * 2018-07-03 2018-10-16 京东方科技集团股份有限公司 一种靶向纳米药物载体及其制备方法和应用

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US20210246163A1 (en) 2021-08-12
US11352390B2 (en) 2022-06-07
CN111868072B (zh) 2023-08-29
WO2020140237A1 (zh) 2020-07-09

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