CN111847343B - Nucleic acid reaction consumptive material switch lid mechanism - Google Patents
Nucleic acid reaction consumptive material switch lid mechanism Download PDFInfo
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- CN111847343B CN111847343B CN202010661609.9A CN202010661609A CN111847343B CN 111847343 B CN111847343 B CN 111847343B CN 202010661609 A CN202010661609 A CN 202010661609A CN 111847343 B CN111847343 B CN 111847343B
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B1/00—Closing bottles, jars or similar containers by applying stoppers
- B67B1/08—Securing stoppers, e.g. swing stoppers, which are held in position by associated pressure-applying means coacting with the bottle neck
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
- B67B—APPLYING CLOSURE MEMBERS TO BOTTLES JARS, OR SIMILAR CONTAINERS; OPENING CLOSED CONTAINERS
- B67B7/00—Hand- or power-operated devices for opening closed containers
- B67B7/02—Hand- or power-operated devices for opening closed containers for removing stoppers
- B67B7/06—Other cork removers
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Abstract
A nucleic acid reaction consumable material switch cover mechanism comprises a first framework layer, a second framework layer and a third framework layer; a plurality of first guide rods are vertically arranged below the first framework layer, the upper ends of the first guide rods are connected with the first framework layer, and the lower ends of the first guide rods penetrate through the second framework layer and the third framework layer; a plurality of second guide rods are vertically arranged between the second framework layer and the third framework layer; the upper end of the second guide rod penetrates through the second framework layer, and the lower end of the second guide rod is connected with the third framework layer; the second guide rod is sleeved with an elastic component; the first framework layer is connected with the second framework layer through a lifting device, and the lifting device is used for driving the second framework layer to move up and down along the guide rod I; a consumable cover fixing mechanism is arranged on the second framework layer and used for fixing the consumable cover on the second framework layer; be provided with consumptive material main part fixed establishment on the third framework layer, consumptive material main part fixed establishment is used for restricting the removal of consumptive material main part. This switch cover mechanism can avoid manual operation and cause the appearance to pollute, simultaneously, can also improve operating efficiency, reduces artifical fatigue strength.
Description
Technical Field
The invention relates to the field of instrument automation, in particular to a consumable opening and closing cover mechanism for nucleic acid reaction.
Background
Nucleic acids are carriers of genetic information in organisms, and isolation, purification, and detection of nucleic acids are required for studies on nucleic acid sequences and structures, or for the search for gene functions and expression.
With the advancement of technology, the automation of nucleic acid extraction and detection equipment will be a necessary trend. However, the fully automatic nucleic acid detection should not be limited to the automation of the nucleic acid extraction and detection processes, but also include the steps of adding the sample, transferring the product, disposing the waste, etc., so as to minimize the contact between the operator and the sample, the reagent, the reaction product, and the waste consumable, and reduce the risks of biological contamination and biohazard.
The existing nucleic acid reaction consumable comprises a consumable body and a consumable cover, the uncovering and covering operations of the existing nucleic acid reaction consumable are all completed by manual operation, the risk that a sample is polluted can be increased, meanwhile, the manual operation efficiency is low, and the manual fatigue strength is high.
Therefore, it is necessary to design a cap opening and closing mechanism for the operation of opening and closing the cap of the consumable for nucleic acid reaction instead of manual operation.
Disclosure of Invention
The invention aims to: to the problem that above-mentioned exists, provide a nucleic acid reaction consumptive material switch lid mechanism, it can avoid manual operation and cause kind to pollute, simultaneously, can also improve operating efficiency, reduce artifical fatigue strength.
The technical scheme adopted by the invention is as follows:
a nucleic acid reaction consumable material cover opening and closing mechanism comprises a first framework layer, a second framework layer and a third framework layer which are sequentially arranged from top to bottom; a plurality of first guide rods are vertically arranged below the first framework layer, the upper ends of the first guide rods are connected with the first framework layer, and the lower ends of the first guide rods penetrate through the second framework layer and the third framework layer, so that the second framework layer and the third framework layer can move up and down along the first guide rods; a lower guide rod limiting block is arranged at the lower end of the first guide rod; the guide rod lower limiting block is positioned below the third framework layer; a plurality of guide rods II are vertically arranged between the second framework layer and the third framework layer; the upper end of the second guide rod penetrates through the second framework layer, the lower end of the second guide rod is connected with the third framework layer, the upper end of the second guide rod is provided with a second upper limiting block of the guide rod, and the second upper limiting block of the guide rod is positioned above the second framework layer; an elastic component is sleeved on the second guide rod and is positioned between the second framework layer and the third framework layer; the first framework layer is connected with the second framework layer through a lifting device, and the lifting device is used for driving the second framework layer to move up and down along the guide rod I;
the second framework layer is provided with a consumable cover fixing mechanism, and the consumable cover fixing mechanism is used for fixing a consumable cover on the second framework layer;
be provided with consumptive material main part fixed establishment on the third framework layer, consumptive material main part fixed establishment is used for restricting the removal of consumptive material main part.
Due to the structure, when the lifting device pushes the second framework layer to move downwards, the third framework layer also moves downwards, and when the third framework layer reaches the limit position, the second framework layer continues to move downwards, so that the elastic component is compressed to apply a downward pushing force to the third framework layer; at this moment, when the consumable main body fixing mechanism on the third framework layer fixes the consumable main body, when the consumable cover fixing mechanism on the second framework layer fixes the consumable cover, the lifting device drives the second framework layer to move upwards for a short distance, so that the consumable cover moves upwards, the elastic component is still in a compression state at this moment, then the third framework layer provides a downward force for the consumable main body, the second framework layer provides an upward force for the consumable cover, the consumable cover and the consumable main body can be separated, the cover opening purpose is reached, when the cover is closed, then only the lifting device is needed to drive the second framework layer to move downwards. The mechanism can be used for conveniently opening and closing the cover of the nucleic acid reaction consumable.
Furthermore, the upper end of the guide rod is connected with the area of the bottom edge-leaning part of the first framework layer, and the lower end of the guide rod penetrates through the areas of the edge-leaning parts of the second framework layer and the third framework layer; the second guide rod is positioned in the area close to the edge of the second framework layer and the third framework layer, the upper end of the second guide rod penetrates through the second framework layer, and the lower end of the second guide rod is connected with the third framework layer.
Due to the structure, the plurality of guide rods I are arranged among the first framework layer, the second framework layer and the third framework layer, so that the stability of the structure can be ensured, and the situation that the first framework layer, the second framework layer and the third framework layer can rotate around the guide rods under the condition that only one guide rod I is arranged is avoided; meanwhile, the first guide rod and the second guide rod are respectively positioned in the edge regions of the first framework layer, the second framework layer and the third framework layer, so that the middle regions of the first framework layer, the second framework layer and the third framework layer are reserved conveniently, and the middle regions of the first framework layer, the second framework layer and the third framework layer are used as operating spaces or operating equipment for opening and closing covers.
Furthermore, a second framework layer limit stop is sleeved on the second guide rod, the second framework layer limit stop is positioned between the second framework layer and the third framework layer, and the elastic assembly is sleeved outside the second framework layer limit stop.
Due to the structure, when the cover is closed, the limit stop of the second framework layer is matched with the elastic component, so that the second framework layer can be prevented from moving downwards to be transited, and the limit stop and the third framework layer are hard to touch, and the equipment is prevented from being damaged.
Further, the lifting device comprises a screw motor and a screw; the screw rod motor is fixedly arranged above or below the first framework layer, the upper end of the screw rod is connected with the screw rod motor, a screw rod connecting seat is arranged above the second framework layer, and the lower end of the screw rod penetrates through the second framework layer and the screw rod connecting seat and is in threaded connection with the screw rod connecting seat; or the lower end of the screw rod is in threaded connection with the screw rod connecting seat.
Because above-mentioned structure, as elevating gear through screw mechanism, the control of the lift distance of being convenient for, simultaneously, the lead screw has the auto-lock characteristic, avoids the second framework layer to appear sliding in the course of the work, guarantees the stability of work.
Furthermore, the consumable cover fixing mechanism comprises a plurality of cover opening strips; each cover opening strip comprises a strip-shaped strip body and a connecting block arranged at the rear end of the strip body, the strip body and the bottom surface of the second framework layer are arranged at intervals, and the rear end of the strip body is connected with the bottom surface of the second framework layer through the connecting block;
the cover opening strips are arranged in a row in parallel at equal intervals, so that the intervals between every two adjacent cover opening strips form consumable cover clamping grooves with bottom openings and front end openings.
Because above-mentioned structure, when the consumptive material lid got into consumptive material lid draw-in groove from consumptive material lid draw-in groove front end opening, both sides about the pipe cover board just alright block under the effect of consumptive material lid draw-in groove, fixed the consumptive material lid on second framework layer, and then alright follow second framework layer and remove.
Furthermore, the front end of the strip body is provided with a cover opening bulge.
Further, the cover opening bulge is positioned above the strip body and comprises a prying cover part and a limiting part; the pry cover part is positioned at the front end of the cover opening bulge, the limiting part is positioned at the rear end of the cover opening bulge, and the front end of the strip body is connected with the lower part of the limiting part.
Due to the structure, the prying cover part can be conveniently inserted into a gap between the consumable cover and the consumable main body, so that the consumable cover can more easily enter the consumable cover clamping groove; when the consumptive material lid is whole to get into consumptive material lid draw-in groove, spacing portion can avoid the consumptive material lid to follow consumptive material lid draw-in groove front end roll-off.
Further, the length of the strip body is more than or equal to that of the consumable cover.
Can make consumptive material lid can partly get into consumptive material lid draw-in groove like this, simultaneously, when the length of the strip body slightly is greater than the length of consumptive material lid, the consumptive material lid just is located between connecting block and the spacing portion, avoids the consumptive material lid to slide, makes things convenient for the location of follow-up closing the lid operation like this.
Furthermore, the consumable main body fixing mechanisms are a plurality of consumable main body fixing grooves which are formed in the third framework layer, are arranged in a row at equal intervals in parallel and penetrate through the third framework layer in the vertical direction; the consumable main body fixing groove is opened at the front end.
Because above-mentioned structure, in the body upper end that the consumptive material main part was in the convenient consumptive material main part got into the fixed slot from fixed slot front end opening for the consumptive material front end opening, when the whole embedding consumptive material main part fixed slots in body upper end in the consumptive material main part, the connecting plate of consumptive material main part can be pushed down to consumptive material main part fixed slot lower limb, is opening the lid in-process fixed consumptive material main part.
Furthermore, the length of the consumable body fixing groove is more than or equal to that of the consumable body.
Furthermore, the extending direction of the consumable body fixing groove is consistent with the extending direction of the consumable cover clamping groove; the quantity of consumptive material main part fixed slot corresponds with the quantity of consumptive material lid draw-in groove to align with consumptive material lid draw-in groove.
Furthermore, a consumable loading platform connecting piece is arranged at the bottom of the third framework layer and used for detachably connecting the third framework layer with the consumable loading platform.
Present consumptive material is mostly placed on the consumptive material loading platform, therefore, the position relatively fixed that can guarantee consumptive material loading platform and third framework layer is connected through consumptive material loading platform connecting piece to third framework layer and consumptive material loading platform, make the third framework lamination on the consumptive material main part, avoid the consumptive material loading platform to take place the displacement in the work simultaneously, also be convenient for consumptive material main part fixed establishment and consumptive material loading platform cooperation simultaneously, with the stable fixing of consumptive material on the consumptive material loading platform, be convenient for subsequent switch lid operation.
Further, the connecting piece of the consumable loading platform is a fixing strip arranged at the bottom of the third framework layer, a clamping interface is arranged on the fixing strip, and the clamping interface is used for enabling a fixing bolt arranged on the side wall of the consumable loading platform to be embedded into the clamping interface in the horizontal direction and limiting the vertical separation of the third framework layer and the consumable loading platform.
Due to the structure, the third framework layer and the consumable loading platform can be quickly connected and separated in the clamping mode.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
the cover opening and closing mechanism can conveniently open and close the nucleic acid reaction consumables, avoid biological pollution caused by manual operation, improve the cover opening and closing efficiency, operate a plurality of consumables in batch at one time, and reduce the manual fatigue strength.
Drawings
FIG. 1 is a structural diagram of consumables for nucleic acid reaction in example 2;
FIG. 2 is a schematic diagram of the lid opening and closing mechanism and the consumable loading station;
FIG. 3 is a block diagram of a consumable loading station;
FIG. 4 is an overall structural view of the opening and closing cover mechanism;
FIG. 5 is a block diagram of a second structural layer;
FIG. 6 is a block diagram of a cover strip;
FIG. 7 is a block diagram of a third structural layer;
FIGS. 8-15 are state diagrams of the uncapping process;
fig. 16-20 are state diagrams of the closing process.
Detailed Description
The present invention will be described in detail below with reference to the accompanying drawings.
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
A nucleic acid reaction consumable material switch cover mechanism comprises a first framework layer 14, a second framework layer 18 and a third framework layer 19 which are arranged from top to bottom in sequence; a plurality of guide rods I20 are vertically arranged below the first framework layer 14, the upper ends of the guide rods I20 are connected with the first framework layer 14, and the lower ends of the guide rods I20 penetrate through the second framework layer 18 and the third framework layer 19, so that the second framework layer 18 and the third framework layer 19 can move up and down along the guide rods I20; a lower guide rod limiting block is arranged at the lower end of the first guide rod 20; the guide rod lower limiting block is positioned below the third framework layer 19; a plurality of guide rods 27 are vertically arranged between the second framework layer 18 and the third framework layer 19; the upper end of the second guide rod 27 penetrates through the second framework layer 18, the lower end of the second guide rod 27 is connected with the third framework layer 19, the upper end of the second guide rod 27 is provided with a second upper limiting block of the second guide rod, and the second upper limiting block of the second guide rod is positioned above the second framework layer 18; the second guide rod 27 is sleeved with an elastic component 21, and the elastic component 21 is positioned between the second framework layer 18 and the third framework layer 19; the first framework layer 14 is connected with the second framework layer 18 through a lifting device, and the lifting device is used for driving the second framework layer 18 to move up and down along a first guide rod 20;
a consumable cover fixing mechanism is arranged on the second framework layer 18 and used for fixing the consumable cover 2 on the second framework layer 18;
and a consumable main body fixing mechanism is arranged on the third framework layer 19 and used for limiting the movement of the consumable main body 1.
The lower guide rod limiting block and the upper guide rod limiting block of the second guide rod are both nuts; the guide rod lower limiting block is used for limiting the third framework layer to move downwards continuously and preventing the third framework layer from falling off from the guide rod I; when the second framework layer moves up and down relative to the second guide rod, the limiting block on the second guide rod is used for separating the second guide rod from the second framework layer.
The upper end of the first guide rod 20 is connected with the area of the bottom edge-leaning part of the first framework layer 14, and the lower end of the first guide rod 20 penetrates through the area of the edge-leaning part of the second framework layer 18 and the third framework layer 19; the second guide rod 27 is positioned in the area close to the edge of the second framework layer 18 and the third framework layer 19, the upper end of the second guide rod 27 penetrates through the second framework layer 18, and the lower end of the second guide rod 27 is connected with the third framework layer 19;
as shown in fig. 4, in the present embodiment, the first structural layer 14, the second structural layer 18, and the third structural layer 19 are all metal flat plates; for example, to ensure stability during operation of the first, second and third structural layers 14, 18, 19, the first guide bar 20 is provided in at least two numbers, so that rotation of the first, second and third structural layers 14, 18, 19 about the first guide bar 20 is avoided. In this embodiment, four first guide rods 20 are vertically disposed and distributed at four corners of the first structural layer 14, the second structural layer 18 and the third structural layer 19, and the middle regions of the first structural layer 14, the second structural layer 18 and the third structural layer 19 are left so as to facilitate the installation of the consumable cover fixing mechanism and the consumable body fixing mechanism in the middle region or use the middle region as an operation space. Meanwhile, in the present embodiment, the second guide rods 27 are also four and distributed at four corners of the first structural layer 14, the second structural layer 18 and the third structural layer 19;
the second framework layer limit stop is sleeved on the second guide rod 27, the second framework layer limit stop is positioned between the second framework layer 18 and the third framework layer 19, and the elastic component 21 is sleeved outside the second framework layer limit stop. The elastic component 21 may be a spring or rubber, and in this embodiment, the elastic component is a spring.
The lifting device can be a cylinder, an oil cylinder, a screw rod mechanism and the like, and in the embodiment, the lifting device comprises a screw rod motor 15 and a screw rod 16; the screw rod motor 15 is fixedly arranged above or below the first framework layer 14, the upper end of the screw rod 16 is connected with the screw rod motor 15, a screw rod connecting seat 17 is arranged above the second framework layer 18, and the lower end of the screw rod 16 penetrates through the second framework layer 18 and the screw rod connecting seat 17 and is in threaded connection with the screw rod connecting seat 17; or the lower end of the screw rod is in threaded connection with the screw rod connecting seat.
Consumptive material lid fixed establishment and consumptive material main part fixed establishment can snatch and fix the mechanism of consumptive material lid 2 and consumptive material main part 1 for the jack catch etc.
And a consumable loading platform connecting piece is arranged at the bottom of the third framework layer 19 and used for detachably connecting the third framework layer 19 and the consumable loading platform 10 together.
The connecting piece of the consumable loading platform is a fixing strip 25 arranged at the bottom of the third framework layer 19, a clamping interface 26 is arranged on the fixing strip 25, the clamping interface 26 is used for enabling a fixing bolt 13 arranged on the side wall of the consumable loading platform 10 to be embedded into the clamping interface 26 from the horizontal direction, and the third framework layer 19 and the consumable loading platform 10 are limited to be separated vertically.
Example 2
This example takes the consumable nucleic acid reaction material shown in FIG. 1 as an example to illustrate the mechanism for opening and closing the lid of the consumable nucleic acid reaction material of the present invention.
As shown in FIG. 1, a consumable for nucleic acid reaction includes a consumable body 1 and a consumable cover 2. The consumable main body 1 comprises a connecting plate 3 and a plurality of pipe bodies 4 inserted into the connecting plate 3, wherein pipe orifices 5 are formed in the pipe bodies 4, the pipe orifices 5 of all the pipe bodies 4 are positioned on the same plane, and the width of the connecting plate 3 is larger than the diameter of the pipe orifices 5 so as to form a first cornice 6 for fixing the pipe bodies 4 when the cover is opened on the outer side wall of the pipe bodies 4; the consumable cover 2 comprises a plurality of pipe covers 7 which correspond to the pipe bodies 4 one by one and are used for blocking the pipe orifices 5, the pipe covers are connected to the same side of the pipe cover plate 8, and second cornices 9 which are taken as stress points when the pipe covers 7 are pulled out of the pipe bodies 4 are arranged on the edges of the pipe covers 7; when the pipe cover 7 covers the pipe body 4, a gap is formed between the second cornice 9 and the first cornice 6, so that the device provided by the invention can be conveniently inserted from the gap, and the cover opening operation is further realized.
The nucleic acid reaction consumptive material is installed on the consumptive material loading platform 10, be provided with the consumptive material draw-in groove 12b that a plurality of consumptive material hole sites 12a and a plurality of parallel equidistant settings on the consumptive material loading platform 10, 1 nestification of consumptive material main part is in consumptive material draw-in groove 12b, places suitable back, and the connecting plate 3 of connecting a plurality of bodys 4 is located consumptive material draw-in groove 12b top, and the mouth of pipe 5 of all bodys 4 all is in the coplanar. Two fixing bolts 13 are respectively arranged on the left side and the right side of the consumable material loading platform 10, and the fixing bolts 13 on the left side and the right side of the front end and the fixing bolts 13 on the two sides of the rear end are not on the same height plane.
Aiming at the nucleic acid reaction consumable material, the invention provides a switch cover mechanism of the nucleic acid reaction consumable material, which comprises a first framework layer 14, a second framework layer 18 and a third framework layer 19 which are arranged from top to bottom in sequence; a plurality of guide rods I20 are vertically arranged below the first framework layer 14, the upper ends of the guide rods I20 are connected with the first framework layer 14, and the lower ends of the guide rods I20 penetrate through the second framework layer 18 and the third framework layer 19, so that the second framework layer 18 and the third framework layer 19 can move up and down along the guide rods I20; a lower guide rod limiting block is arranged at the lower end of the first guide rod 20; the guide rod lower limiting block is positioned below the third framework layer 19; a plurality of guide rods 27 are vertically arranged between the second framework layer 18 and the third framework layer 19; the upper end of the second guide rod 27 penetrates through the second framework layer 18, the lower end of the second guide rod 27 is connected with the third framework layer 19, the upper end of the second guide rod 27 is provided with a second upper limiting block of the second guide rod, and the second upper limiting block of the second guide rod is positioned above the second framework layer 18; the second guide rod 27 is sleeved with an elastic component 21, and the elastic component 21 is positioned between the second framework layer 18 and the third framework layer 19; the first framework layer 14 is connected with the second framework layer 18 through a lifting device, and the lifting device is used for driving the second framework layer 18 to move up and down along a first guide rod 20;
a consumable cover fixing mechanism is arranged on the second framework layer 18 and used for fixing the consumable cover 2 on the second framework layer 18;
and a consumable main body fixing mechanism is arranged on the third framework layer 19 and used for limiting the movement of the consumable main body 1.
The lower guide rod limiting block and the upper guide rod limiting block of the second guide rod are both nuts; the guide rod lower limiting block is used for limiting the third framework layer to move downwards continuously and preventing the third framework layer from falling off from the guide rod I; when the second framework layer moves up and down relative to the second guide rod, the limiting block on the second guide rod is used for separating the second guide rod from the second framework layer.
The upper end of the first guide rod 20 is connected with the area of the bottom edge-leaning part of the first framework layer 14, and the lower end of the first guide rod 20 penetrates through the area of the edge-leaning part of the second framework layer 18 and the third framework layer 19; the second guide rod 27 is located in the area of the side portions of the second framework layer 18 and the third framework layer 19, the upper end of the second guide rod 27 penetrates through the second framework layer 18, and the lower end of the second guide rod 27 is connected with the third framework layer 19.
As shown in fig. 4, in the present embodiment, the first structural layer 14, the second structural layer 18, and the third structural layer 19 are all metal flat plates; for example, to ensure the stability of the first, second and third structural layers 14, 18, 19 during operation, at least two guide rods one 20 are provided, so that rotation of the first, second and third structural layers 14, 18, 19 about the guide rods one 20 is avoided. In this embodiment, four first guide rods 20 are vertically disposed and distributed at four corners of the first structural layer 14, the second structural layer 18 and the third structural layer 19, and the middle regions of the first structural layer 14, the second structural layer 18 and the third structural layer 19 are left so as to facilitate the installation of the consumable cover fixing mechanism and the consumable body fixing mechanism in the middle region or use the middle region as an operation space. Meanwhile, in the present embodiment, the second guide rods 27 are also four and distributed at four corners of the first structural layer 14, the second structural layer 18 and the third structural layer 19;
the second framework layer limit stop is sleeved on the second guide rod 27, the second framework layer limit stop is positioned between the second framework layer 18 and the third framework layer 19, and the elastic component 21 is sleeved outside the second framework layer limit stop. The elastic member 21 may be a spring or rubber, and in this embodiment, the elastic member is a spring.
The lifting device can be a cylinder, an oil cylinder, a screw rod mechanism and the like, and in the embodiment, the lifting device comprises a screw rod motor 15 and a screw rod 16; the screw rod motor 15 is fixedly arranged above or below the first framework layer 14, the upper end of the screw rod 16 is connected with the screw rod motor 15, a screw rod connecting seat 17 is arranged above the second framework layer 18, and the lower end of the screw rod 16 penetrates through the second framework layer 18 and the screw rod connecting seat 17 and is in threaded connection with the screw rod connecting seat 17.
The consumable cover fixing mechanism can be a mechanism for grabbing and fixing the consumable cover 2 by a claw and the like, and in order to simplify the structure, the consumable cover fixing mechanism with a simple structure is specially designed for the nucleic acid reaction consumable in fig. 1; the consumable cover fixing mechanism comprises a plurality of cover opening strips; each cover opening strip comprises a strip-shaped strip body 23 and a connecting block 23b arranged at the rear end of the strip body, the strip body 23 and the bottom surface of the second structural layer are arranged at intervals, and the rear end of the strip body 23 is connected with the bottom surface of the second structural layer 18 through the connecting block 23 b;
the cover opening strips are arranged in a row in parallel at equal intervals, so that the consumable cover clamping grooves 22 with bottom openings and front end openings are formed at intervals between every two adjacent cover opening strips.
The front end of the strip body 23 is provided with a cover opening bulge 23 a.
The cover opening bulge 23a is positioned above the bar body 23, and the cover opening bulge 23a comprises a prying cover part and a limiting part; the sledge cover part is positioned at the front end of the cover opening bulge 23a, the limiting part is positioned at the rear end of the cover opening bulge 23a, and the front end of the strip body 23 is connected with the lower part of the limiting part.
As shown in fig. 6, this arch of uncapping 23a is right triangle, and its hypotenuse is the sled lid, and the right-angle side is spacing portion, and the lower part on right-angle side links to each other with strip body 23, and the sled lid is located the place ahead of spacing portion for insert the gap between consumptive material lid 2 and consumptive material main part 1, then prize consumptive material lid 2, after 2 whole nestings of consumptive material lid are in consumptive material lid draw-in groove 22, spacing portion can now 2 landing of consumptive material lid.
The length of the strip body 23 is greater than or equal to the length of the consumable cover 2.
An arc chamfer is arranged at the joint of the connecting block 23b and the strip body 23, and an arc chamfer is arranged at the joint of the strip body 23 and the uncovering bulge 23 a. The arc-shaped chamfer plays a guiding role, and when deviation of the running precision of the instrument is avoided, the consumable cover and the cover opening strip are in hard touch and guide contact.
The consumable main body fixing mechanisms are a plurality of consumable main body fixing grooves 24 formed in the third framework layer 19, and the consumable main body fixing grooves 24 are arranged in parallel at equal intervals in a row and penetrate through the third framework layer 19 in the vertical direction; the 24 front end openings in consumptive material main part fixed slot make things convenient for 4 upper ends of body on the consumptive material main part 1 to get into the fixed slot from the fixed slot front end opening in, when 4 upper ends of body on the consumptive material main part 1 are whole to be embedded into consumptive material main part fixed slot 24 in, the connecting plate 3 of consumptive material main part 1 can be pushed down to 24 lower edges in consumptive material main part fixed slot, is uncapping the in-process fixed consumptive material main part 1.
The length of the consumable body fixing groove is more than or equal to that of the consumable body 1.
The extending direction of the consumable body fixing groove 24 is consistent with the extending direction of the consumable cover clamping groove 22; the number of the consumable body fixing grooves 24 corresponds to the number of the consumable cover card slots 22, and is aligned with the consumable cover card slots 22.
The bottom of the third framework layer 19 is provided with a consumable loading platform connecting piece which is used for detachably connecting the third framework layer 19 and the consumable loading platform 10 together.
When third framework layer 19 and consumptive material load table 10 are connected through consumptive material load table connecting piece, can guarantee that the position relatively fixed of consumptive material load table 10 and third framework layer 19 avoids consumptive material load table 10 to take place the displacement in the work, also be convenient for simultaneously consumptive material main part fixed establishment and consumptive material load table 10 cooperation, fix the consumptive material stably on consumptive material load table 10, subsequent switch lid operation of being convenient for.
The connecting piece of the consumable loading platform is a fixing strip 25 arranged at the bottom of the third framework layer 19, a clamping interface 26 is arranged on the fixing strip 25, the clamping interface 26 is used for enabling a fixing bolt 13 arranged on the side wall of the consumable loading platform 10 to be embedded into the clamping interface 26 from the horizontal direction, and the third framework layer 19 and the consumable loading platform 10 are limited to be separated vertically.
As shown in fig. 4, a left fixing strip 25 and a right fixing strip 25 are disposed below the third layer of the framework, the front end and the rear end of each fixing strip 25 are respectively provided with a clamping interface 26 with the same opening direction, and the clamping interfaces 26 at the two ends are not on the same height plane and respectively correspond to the two fixing bolts 13 disposed on the left side and the right side of the consumable loading platform 10. The fixing clip interface 26 can be matched with the fixing bolt 13, a four-point fixing effect is achieved between the third layer of the framework layer and the consumable loading platform 10, and corresponding cover opening and closing operations are completed in a matching mode.
The uncapping method comprises the following steps:
before the experiment is started, the user places the reaction consumables in the closed state into the consumable clamping grooves 12b of the consumable loading table 10.
Firstly, the consumable loading table 10 is driven by the moving mechanism to move to a position corresponding to the inlet end of the cover opening and closing mechanism 11 along the Y-axis direction, as shown in FIG. 8;
in the invention, the X-axis direction, the Y-axis direction and the Z-axis direction are the directions shown in fig. 2, the consumable clamping groove 12b, the consumable cover clamping groove 22 and the consumable body fixing groove 24 all extend along the Y-axis and are arranged in parallel at equal intervals along the X-axis direction, and the inlet end of the cover opening and closing mechanism 11 is the front end opening position of the consumable cover clamping groove 22 and the consumable body fixing groove 24;
next, the screw motor 15 pushes the second structural layer 18 and the third structural layer 19 to move downward along the Z axis, so that the third structural layer 19 reaches a lower limit position, and at this time, the lower edge of the consumable body fixing groove 24 on the third structural layer 19 corresponds to the connecting plate 3 of the consumable body 1, that is, the lower edge of the consumable body fixing groove 24 is flush with the upper surface of the connecting plate 3, as shown in fig. 9;
next, the lead screw motor 15 continues to push the second structural layer 18 to move downward along the Z-axis, and compresses the four springs between the second structural layer 18 and the third structural layer 19, so that the highest point of the uncovering protrusion 23a at the inlet end of the consumable cover clamping groove 22 on the second structural layer 18 is slightly higher than the tube cover plate 8 of the consumable cover 2, as shown in fig. 10;
next, the moving mechanism drives the consumable loading platform 10 to move along the Y-axis direction, and the moving mechanism is close to the cover opening and closing mechanism 11, so that a small part of the second cornice 9 of the pipe cover plate 8 enters the inlet end of the consumable cover clamping groove 22, meanwhile, the lower edge of the consumable body fixing groove 24 can press the connecting plate 3 of the consumable body 1, and the consumable body 1 is fixed on the consumable loading platform 10, as shown in fig. 11;
next, the consumable loading platform 10 moves along the Y-axis direction, so that the second cornice 9 of the tube cover plate 8 further enters the inlet end of the consumable cover clamping groove 22, and the cover opening protrusion 23a prying cover part slightly pries the consumable cover 2. At this time, the lower edge of the consumable body fixing groove 24 still presses the connection plate 3 of the consumable body 1 for fixing, as shown in fig. 12;
next, the screw motor 15 drives the second framework layer 18 to move upwards for a short distance along the Z-axis for increasing the force of the uncovering protrusion 23a for prying the consumable cover 2. At this time, the four springs between the second structural layer 18 and the third structural layer 19 are still in a compressed state, and the lower edge of the consumable body fixing groove 24 still presses the first eave 6 of the consumable body 1 to fix the same, as shown in fig. 13;
next, the consumable loading table 10 continues to move along the Y-axis direction until the consumable covers 2 are completely submerged into the consumable cover slots 22, and in this process, the cover-opening protrusions 23a pry all the consumable covers 2. Finally, the consumable lid 2 is fully inserted into the consumable lid slot 22. In addition, in the process, the two fixing bolts 13 respectively arranged at the left side and the right side of the consumable loading platform 10 are respectively clamped into the clamping ports 26 at the two ends of the two fixing strips 25 below the switch cover mechanism 11 to form four-point fixation, as shown in fig. 14;
finally, the lead screw motor 15 drives the second framework layer 18 to move upwards along the Z-axis, and the consumable cover 2 inserted into the consumable cover clamping groove 22 at this time is completely pulled up by taking the second cornice 9 as a stress point, as shown in fig. 15. At this time, four springs between the second structural layer 18 and the third structural layer 19 are in a compressed state; meanwhile, four-point fixation is formed between the third framework layer 19 and the consumable loading platform 10 through the fixing bolts 13 and the clamping interfaces 26, the lower edge of the consumable body fixing groove 24 is guaranteed to press the first cornice 6 of the consumable body 1 together, the fixing effect is achieved, and the operation of opening and closing the cover is completed in a matching mode. Meanwhile, in the invention, as the third structural layer 19 and the second structural layer 18 are provided with the elastic component 21, the third structural layer 19 can move up and down, so that the phenomenon that the switch mechanism or the consumable is damaged due to direct hard contact between the third structural layer 19 and the consumable main body 1 is avoided, and the spring also plays a role of buffering.
The cover closing method comprises the following steps:
after the experiment is finished, all the nucleic acid reaction consumables are in an uncapped state, and the consumable body 1 is positioned in the consumable clamping groove 12b of the consumable loading platform 10; the consumable lid 2 is nested in the consumable lid slot 22 of the second shelf.
First, the consumable loading table 10 is moved in the Y-axis direction to a position corresponding to the inlet end of the opening and closing cover mechanism 11, as shown in fig. 16;
next, the screw motor 15 pushes the second structural layer 18 and the third structural layer 19 to move downwards along the Z axis, so that the third structural layer 19 reaches a lower limit position, at this time, the lower edge of the consumable body fixing groove 24 on the third structural layer 19 corresponds to the connecting plate 3 of the consumable body 1, that is, the lower edge of the consumable body fixing groove 24 is flush with the upper surface of the connecting plate 3; the consumable cover 2 is nested in the second shelf consumable cover clamping groove 22, and the opening 7 of the tube cover is higher than the height of the opening 5 of the consumable body 1 of the loading platform, as shown in fig. 17;
next, the consumable loading table 10 continues to move in the Y-axis direction until all of the consumable body 1 is submerged into the consumable body fixing groove 24, as shown in fig. 18;
next, the screw motor 15 pushes the second framework layer 18 to move downwards along the Z-axis, so that the consumable cover 2 nested in the consumable cover clamping groove 22 is covered on the consumable body 1; the screw motor 15 continues to push the second framework layer 18 to move downwards along the Z-axis until the tube cover 7 covers the tube body 4, and the cover closing operation is completed, as shown in fig. 19;
next, the lead screw motor 15 drives the second framework layer 18 to move upwards for a short distance along the Z-axis, so that the highest point of the uncovering protrusion is slightly lower than the tube cover plate 8 of the consumable cover 2, and the consumable loading table 10 exits the cover opening and closing mechanism 11 along the Y-axis direction, as shown in fig. 20;
finally, the consumable material loading table 10 exits the cover opening and closing mechanism 11 along the Y-axis direction, and the cover opening and closing mechanism 11 moves upwards along the Z-axis direction to be reset.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (13)
1. The utility model provides a nucleic acid reaction consumptive material switch lid mechanism which characterized in that: the structure comprises a first structural layer (14), a second structural layer (18) and a third structural layer (19) which are arranged from top to bottom in sequence; a plurality of guide rods I (20) are vertically arranged below the first framework layer (14), the upper ends of the guide rods I (20) are connected with the first framework layer (14), and the lower ends of the guide rods I (20) penetrate through the second framework layer (18) and the third framework layer (19), so that the second framework layer (18) and the third framework layer (19) can move up and down along the guide rods I (20); the lower end of the guide rod I (20) is provided with a lower guide rod limiting block; the guide rod lower limiting block is positioned below the third framework layer (19); a plurality of second guide rods (27) are vertically arranged between the second framework layer (18) and the third framework layer (19); the upper end of the second guide rod (27) penetrates through the second framework layer (18), the lower end of the second guide rod (27) is connected with the third framework layer (19), a second upper guide rod limiting block is arranged at the upper end of the second guide rod (27), and the second upper guide rod limiting block is positioned above the second framework layer (18); an elastic component (21) is sleeved on the second guide rod (27), and the elastic component (21) is positioned between the second framework layer (18) and the third framework layer (19); the first framework layer (14) is connected with the second framework layer (18) through a lifting device, and the lifting device is used for driving the second framework layer (18) to move up and down along the guide rod I (20);
a consumable cover fixing mechanism is arranged on the second framework layer (18) and used for fixing the consumable cover (2) on the second framework layer (18);
a consumable main body fixing mechanism is arranged on the third framework layer (19) and used for limiting the movement of the consumable main body (1);
the lifting device can push the second framework layer (18) to move downwards, the third framework layer (19) also moves downwards, and when the third framework layer (19) reaches the limit position, the second framework layer (18) continues to move downwards, so that the elastic component (21) is compressed to apply a downward pushing force to the third framework layer (19).
2. The consumable opening and closing cap mechanism for nucleic acid reaction according to claim 1, wherein:
the upper end of the guide rod I (20) is connected with the area of the bottom edge-close part of the first framework layer (14), and the lower end of the guide rod I (20) penetrates through the area of the edge-close parts of the second framework layer (18) and the third framework layer (19); the second guide rod (27) is located in the area close to the edge of the second framework layer (18) and the third framework layer (19), the upper end of the second guide rod (27) penetrates through the second framework layer (18), and the lower end of the second guide rod (27) is connected with the third framework layer (19).
3. The consumable opening and closing cap mechanism for nucleic acid reaction according to claim 1, wherein: the second framework layer limit stop is sleeved on the second guide rod (27), the second framework layer limit stop is positioned between the second framework layer (18) and the third framework layer (19), and the elastic component (21) is sleeved outside the second framework layer limit stop.
4. The consumable opening and closing cap mechanism for nucleic acid reaction according to claim 1, wherein:
the lifting device comprises a screw motor (15) and a screw (16); the screw rod motor (15) is fixedly arranged above or below the first framework layer (14), the upper end of the screw rod (16) is connected with the screw rod motor (15), a screw rod connecting seat (17) is arranged above the second framework layer (18), and the lower end of the screw rod (16) penetrates through the second framework layer (18) and the screw rod connecting seat (17) and is in threaded connection with the screw rod connecting seat (17); or the lower end of the screw rod (16) is in threaded connection with the screw rod connecting seat (17).
5. The consumable opening and closing mechanism for nucleic acid reaction according to claim 1, wherein:
the consumable cover fixing mechanism comprises a plurality of cover opening strips; each cover opening strip comprises a strip-shaped strip body (23) and a connecting block (23b) arranged at the rear end of the strip body, the strip body (23) and the bottom surface of the second layer of framework layer are arranged at intervals, and the rear end of the strip body (23) is connected with the bottom surface of the second framework layer (18) through the connecting block (23 b);
the cover opening strips are arranged in a row in parallel at equal intervals, so that consumable cover clamping grooves (22) with bottom openings and front end openings are formed at intervals between every two adjacent cover opening strips.
6. The consumable opening and closing cap mechanism for nucleic acid reaction according to claim 5, wherein: the front end of the strip body (23) is provided with an uncovering bulge (23 a).
7. The consumable opening and closing cap mechanism for nucleic acid reaction according to claim 6, wherein: the cover opening bulge (23a) is positioned above the strip body (23), and the cover opening bulge (23a) comprises a prying cover part and a limiting part; the prying cover part is positioned at the front end of the cover opening bulge (23a), the limiting part is positioned at the rear end of the cover opening bulge (23a), and the front end of the strip body (23) is connected with the lower part of the limiting part.
8. The consumable opening and closing cap mechanism for nucleic acid reaction according to claim 7, wherein: the length of the strip body (23) is more than or equal to that of the consumable cover (2).
9. The consumable opening/closing cap mechanism for nucleic acid reaction according to claim 1 or 8, wherein: the consumable main body fixing mechanisms are a plurality of consumable main body fixing grooves (24) formed in the third framework layer (19), and the consumable main body fixing grooves (24) are arranged in parallel at equal intervals in a row and penetrate through the third framework layer (19) in the vertical direction; the front end of the consumable body fixing groove (24) is opened.
10. The consumable opening and closing cap mechanism for nucleic acid reaction according to claim 9, wherein: the length of the consumable body fixing groove is more than or equal to that of the consumable body (1).
11. The consumable opening and closing cap mechanism for nucleic acid reaction according to claim 9, wherein: the extending direction of the consumable body fixing groove (24) is consistent with the extending direction of the consumable cover clamping groove (22); the number of the consumable body fixing grooves (24) corresponds to the number of the consumable cover clamping grooves (22) and is aligned with the consumable cover clamping grooves (22).
12. The consumable opening and closing cap mechanism for nucleic acid reaction according to claim 1, wherein: and a consumable loading platform connecting piece is arranged at the bottom of the third framework layer (19), and is used for detachably connecting the third framework layer (19) and the consumable loading platform (10).
13. The consumable opening and closing cap mechanism for nucleic acid reaction according to claim 12, wherein: the connecting piece of the consumable loading table is a fixing strip (25) arranged at the bottom of the third framework layer (19), a clamping interface (26) is arranged on the fixing strip (25), the clamping interface (26) is used for enabling a fixing bolt (13) arranged on the side wall of the consumable loading table (10) to be embedded into the clamping interface (26) from the horizontal direction, and the third framework layer (19) and the consumable loading table (10) are limited to be separated from each other from top to bottom.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010661609.9A CN111847343B (en) | 2020-07-10 | 2020-07-10 | Nucleic acid reaction consumptive material switch lid mechanism |
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| CN202010661609.9A CN111847343B (en) | 2020-07-10 | 2020-07-10 | Nucleic acid reaction consumptive material switch lid mechanism |
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| CN111847343B true CN111847343B (en) | 2022-05-17 |
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| JP4210306B2 (en) * | 2007-01-15 | 2009-01-14 | 株式会社アイディエス | Test tube automatic opening device |
| CN101798047B (en) * | 2010-03-17 | 2011-09-14 | 珠海倍健电子科技有限公司 | Full-automatic vacuum test tube uncapping machine |
| JP5963862B2 (en) * | 2011-08-02 | 2016-08-03 | スリーエム イノベイティブ プロパティズ カンパニー | Cap operation tool and method of use |
| CN103130157B (en) * | 2013-03-13 | 2014-12-10 | 东莞市寮步医院 | Blood collection tube uncovering and covering all-in-one machine and blood collection tube rack thereof |
| CN209922861U (en) * | 2018-09-13 | 2020-01-10 | 常州市第二人民医院 | Mechanical automatic uncovering device for penicillin bottle |
| CN210886073U (en) * | 2019-10-12 | 2020-06-30 | 苏州天隆生物科技有限公司 | Reaction consumable for automatic nucleic acid extraction |
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