CN111841679A - Centrifuge tube with double-layer structure - Google Patents
Centrifuge tube with double-layer structure Download PDFInfo
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- CN111841679A CN111841679A CN202010872051.9A CN202010872051A CN111841679A CN 111841679 A CN111841679 A CN 111841679A CN 202010872051 A CN202010872051 A CN 202010872051A CN 111841679 A CN111841679 A CN 111841679A
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- pipe
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- communication hole
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5021—Test tubes specially adapted for centrifugation purposes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/16—Reagents, handling or storing thereof
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Abstract
The invention relates to a centrifuge tube with a double-layer structure, which comprises an inner tube and an outer tube, wherein the inner tube is provided with a first inner cavity, the outer tube is provided with a second inner cavity, the outer tube is sleeved outside the inner tube, an annular sealing ring is arranged between the outer tube and the inner tube, the annular sealing ring is fixed on the outer tube and used for realizing sliding sealing, the inner tube is provided with a communication hole for communicating the first inner cavity with the second inner cavity, the outer tube is provided with a sealing element for sealing the communication hole, and the outer tube is used for moving to a second position from a first position relative to the; the centrifugal tube provided by the invention has a double-layer structure, can conveniently, safely and pollution-free separate supernatant after centrifugation is finished, can effectively avoid disturbing a sample gathered at a lower layer due to pouring of the supernatant, further pour out rare cell components along with the supernatant, and more importantly, can effectively store and isolate the separated supernatant, thereby effectively preventing biological pollution and effectively avoiding biological potential safety hazard.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a centrifugal tube with a double-layer structure.
Background
The centrifugal tube is a test tube for centrifugation and mainly comprises a conical centrifugal tube, a flat-bottom centrifugal tube and a round-bottom centrifugal tube, wherein the conical centrifugal tube is used in the largest amount, and is usually used for separation and preparation of biological samples in the medical field, namely, a biological sample suspension can be contained in the centrifugal tube and is driven by a rotary device to rotate at a high speed, and suspended micro particles (such as organelles and precipitates of biological macromolecules and the like) are settled at a certain speed due to the action of huge centrifugal force, so that the separation of the suspended micro particles from a solution is realized; for example, in the field of cytopathology, loose cells lacking adhesion in an obtained cell sample are required to be aggregated in a net manner by using a centrifuge tube to form a cell mass (similar to a tissue mass), and then the cell mass is dehydrated, embedded and sliced, so that a series of subsequent experiments such as immunocytochemistry staining and molecular detection can be performed, and the purposes of long-term preservation, accurate detection and clinical targeted therapy guidance of the cell sample are achieved.
At present, the application of a centrifuge tube in the medical field is very wide, and in the actual use process, a sample contained in the centrifuge tube usually comes from a human body, after the centrifugal operation is completed, the supernatant of the centrifuge tube usually needs to be separated to obtain the sample deposited at the bottom of the centrifuge tube, however, the existing centrifuge tube can only pour out the supernatant inside through the tube opening of the centrifuge tube, not only is the supernatant inconvenient to separate, but also the sample at the lower layer is easy to disturb in the separation process, so that the sample is mixed into the supernatant again and flows out of the centrifuge tube along with the supernatant, which causes the loss of the sample, in addition, the supernatant and the sample usually contain biological information of the human body, such as cell tissues, DNA information and the like, and even carry various microorganisms such as tuberculosis, viruses and the like, and the existing method is adopted to separate the supernatant and the sample, which inevitably has pollution problems and biological safety hazards, however, the prior art does not provide any effective technical means to solve the problem, and needs to be solved urgently.
Disclosure of Invention
The centrifugal tube has a double-layer structure, can conveniently, safely and pollution-free separate supernatant after centrifugation is finished, can effectively avoid disturbing samples gathered at a lower layer, and can effectively store and isolate the separated supernatant, so that pollution is effectively prevented, and biological potential safety hazards are effectively avoided.
The technical scheme adopted by the invention is as follows:
the invention provides a centrifuge tube with a double-layer structure, aiming at solving the problems of safe and pollution-free separation and storage of supernatant in the centrifuge tube, the centrifuge tube comprises an inner tube, the inner tube is provided with a first inner cavity and a first opening, the first opening is communicated with the first inner cavity,
an outer tube having a second interior cavity and a second opening in communication with the second interior cavity,
the outer pipe is sleeved outside the inner pipe, an annular sealing ring is arranged between the outer pipe and the inner pipe, the annular sealing ring is fixed on the outer pipe and used for realizing sliding sealing and forming a closed cavity between the outer pipe and the inner pipe, the inner pipe is provided with a communication hole used for communicating the first inner cavity and the second inner cavity, the communication hole is arranged at a set distance from the bottom of the first inner cavity,
the outer tube is provided with a sealing member for closing the communication hole,
the outer pipe is used for moving from a first position to a second position relative to the inner pipe, when the outer pipe is located at the first position, the volume of a cavity formed between the outer pipe and the inner pipe is minimum, the sealing member closes the communication hole, when the outer pipe moves from the first position to the second position, the sealing member opens the communication hole, negative pressure is formed between the outer pipe and the inner pipe, and when the outer pipe is located at the second position, the volume of the cavity formed between the outer pipe and the inner pipe is maximum. In the scheme, the inner tube and the outer tube are arranged, so that a biological sample can be added into the first inner cavity through the first opening, the outer tube is provided with the annular sealing ring, a closed cavity can be formed between the outer tube and the inner tube, and when the outer tube moves relative to the inner tube under the action of external force, the annular sealing ring moves along with the outer tube and ensures that the outer tube and the inner tube are in a sealing state, so that negative pressure is formed between the outer tube and the inner tube; the communicating hole can be arranged at the position corresponding to the bottom of the supernatant liquid so as to effectively separate the supernatant liquid; the specific using process is as follows: the centrifuge tube can be placed still or centrifugally operated according to a conventional use method; when the standing or the centrifugation is finished and the supernatant needs to be separated, a user pulls the outer tube to enable the outer tube to move relative to the inner tube, the sealing element is enabled to be separated from the communication hole, the first inner cavity is enabled to be communicated with the second inner cavity through the communication hole, the supernatant can enter the second inner cavity through the communication hole, in the process that the outer tube moves relative to the inner tube, negative pressure can be formed between the outer tube and the inner tube, the supernatant can be smoothly sucked into the second inner cavity, when or before the outer tube moves to the second position, the supernatant can completely enter the outer tube through the communication hole, at the moment, the residual in the inner tube is just the required sample, the user can conveniently take the sample, when the outer tube is at the second position, the outer tube can be separated from the inner tube, so that the second opening of the outer tube can be independently sealed, and the supernatant can be safely and stored without pollution, thereby effectively preventing pollution and effectively putting an end to the biological potential safety hazard, the outer pipe can also be locked on the inner pipe, and the communication hole is not communicated with the outer pipe, and the sealing of the second inner cavity can also be realized, so the purposes of separating and storing supernatant liquid safely and without pollution can be achieved; this centrifuging tube not only can utilize the separation supernatant of negative pressure convenience, safety, pollution-free after the centrifugation is accomplished to can effectively avoid turning the centrifuging tube and empty the sample that the disturbance gathered in the lower floor when supernatant by the upper end, can effectively store and keep apart the supernatant of isolating moreover, thereby effectively prevent to pollute and effectively stop biological potential safety hazard.
To prevent contamination, the device further comprises a sealing member which detachably opens/closes the first opening. The first inner cavity is ensured to have good sealing performance, pollution is prevented, and especially in centrifugation, the sample in the inner tube can be effectively prevented from splashing.
In order to realize the detachable connection of the sealing component, preferably, the sealing component is a rubber plug,
or, the sealing part is a sealing cover, the first opening is provided with an external thread, and the sealing cover is provided with an internal thread matched with the external thread. So as to effectively close/open the first opening.
In a second aspect of the present invention, to solve the problem that the outer tube is detachably fixed at the first position, further, an inner thread is provided on an inner wall of the outer tube, the annular sealing ring is disposed below the inner thread, an outer thread adapted to the inner thread is provided on a position of the outer wall of the inner tube, which is set apart from the first opening, and the outer tube is fixed at the first position by the fitting between the inner thread and the outer thread. Through threaded connection, not only can be convenient die lock the outer tube in the first position department that sets for, the user of being convenient for unlocks moreover.
The third aspect of the invention aims to solve the problem that the supernatant in the inner tube enters the outer tube without pollution, and further comprises an air hole and an airtight component for sealing the air hole,
the air hole is arranged on the side wall of the inner tube and communicated with the first inner cavity, the air hole is positioned above the outer tube, or the air hole is arranged on the sealing part,
the airtight component is a rubber plug or an airtight cover. In this scheme, through setting up the gas pocket and sealing the airtight part of gas pocket for at the in-process that utilizes negative pressure separation supernatant, can needn't open whole sealing member, only need open the gas pocket, can make the first cavity of inner tube can be linked together with the atmosphere, when guaranteeing that the smooth effect of negative pressure that gets into the second cavity of supernatant, make first inside cavity have good closure, thereby effectively prevent to take place the pollution problem.
In a fourth aspect of the present invention, to solve the problem of opening/closing the communication hole by rotation/movement of the outer tube, further, the sealing member is an elastic gasket disposed on an inner wall of the outer tube, and when the outer tube is located at the first position, the elastic gasket is located outside the communication hole and presses an outer wall of the inner tube around the communication hole;
and/or, the sealing member is an elastic bulge arranged on the inner wall of the outer pipe, and when the outer pipe is located at the first position, the elastic bulge is clamped into the communication hole and seals the communication hole. In the scheme, the sealing element is arranged to be the elastic gasket and/or the elastic bulge, the sealing element is driven to be elastically compressed by utilizing the extrusion force between the outer pipe and the inner pipe, and the communication hole is compressed, so that the purpose of sealing the communication hole is achieved, when the outer pipe rotates and/or moves relative to the inner pipe, the sealing element can be driven to synchronously move, so that the sealing element and the communication hole are staggered relative to each other, and the purpose of driving the communication hole to be opened/closed according to the rotation and/or the movement of the outer pipe is achieved.
The fifth aspect of the invention aims to solve the problem of stress balance between the outer pipe and the inner pipe, and further comprises at least two sealing elements which are uniformly distributed along the circumferential direction of the inner wall of the outer pipe. In this scheme, set up a plurality of sealing members through the circumferencial direction along the outer tube for along circumferencial direction's atress distribution is even between inner tube and the outer tube, ensures that through-hole department has stable, reliable sealing pressure, more is favorable to sealing, and through the cooperation with ring type seal circle, makes between outer tube and the inner tube along length direction's stress distribution more even, thereby is favorable to retraining outer tube and locates for the second position of inner tube rectilinear movement.
The sixth aspect of the present invention is to solve: the problem of how to lock and limit the outer tube and how to effectively close the space between the outer tube and the inner tube when the second position is configured at a position where the outer tube does not depart from the inner tube, further, the outer wall of the inner tube is configured with a first restraining part, the first restraining part is arranged at the second position, the first restraining part is configured with a guide surface and a limiting surface, wherein,
the guide surface faces upward of the inner pipe and guides the annular seal ring to move in a direction away from the first opening,
the limiting surface faces the lower part of the inner pipe and is used for limiting the annular sealing ring to move along the direction close to the first opening;
the communicating hole is positioned below the first restraining component, and the width of the annular sealing ring is larger than the maximum distance between the communicating hole and the first restraining component. In the scheme, the first constraint component is constructed, the annular sealing ring can be effectively constrained and limited, so that the aim of constraining the outer pipe at the second position is fulfilled, and the annular sealing ring can completely cover the communication hole when moving to the lower part of the first constraint component because the width of the annular sealing ring is larger than the maximum distance between the communication hole and the first constraint component, so that the aims of closing the communication hole, keeping the cavity between the inner pipe and the outer pipe in a closed state and effectively preventing supernatant from leaking from the communication hole are fulfilled; in addition, because a closed cavity is formed between the inner pipe and the outer pipe, the outer pipe can not move relative to the inner pipe under the action of pressure, and therefore the separation of the outer pipe and the inner pipe is effectively prevented.
Preferably, the guide surface is a slope or an arc surface, and/or the limiting surface is a plane and is perpendicular to the central axis of the inner tube. So as to guide the outer pipe to move to the second position and stably lock at the second position.
Preferably, the first restriction member is of an annular structure and is disposed along a circumferential direction of the inner tube,
or, the inner pipe comprises a plurality of first constraint parts which are uniformly distributed along the circumferential direction of the inner pipe. The annular sealing ring is more favorably limited and locked, so that the aim of locking the outer pipe is fulfilled.
In order to enhance the locking effect, the locking device further comprises a second constraint component, the second constraint component is arranged on the outer wall of the inner tube and is positioned below the first constraint component, the distance between the first constraint component and the second constraint component is larger than or equal to the width of the annular sealing ring, and the first constraint component and the second constraint component are respectively used for constraining the upper end and the lower end of the annular sealing ring. The second constraint part is arranged and matched with the first constraint part, so that the annular sealing ring is just clamped between the first constraint part and the second constraint part when the outer pipe moves to the set second position, and the purpose of locking the outer pipe is achieved.
The seventh aspect of the invention aims to solve the problem that the sediment at the lower part of the inner pipe is convenient to take out: further, the inner pipe comprises an upper pipe section and a lower pipe section, the lower end of the upper pipe section and the upper end of the lower pipe section are connected into a whole through threads, the outer diameters of the upper pipe section and the lower pipe section are the same,
the lower end of the lower pipe section is closed, the communication hole and the first restriction member are respectively configured at the lower pipe section,
the first opening is configured at an upper end of the upper tube section. In the scheme, the inner pipe is connected into a whole through the threaded connection of the upper pipe section and the lower pipe section, and the outer diameters of the upper pipe section and the lower pipe section are kept to be the same, so that the annular sealing ring has a good sealing effect when moving along the outer wall of the inner pipe; because the sediments and the like in the inner pipe are gathered in the lower pipe section, after the separation work of the supernatant is completed, a user can manually separate the upper pipe section and the lower pipe section, and the lower pipe section is connected with the outer pipe into a whole, so that the sediments and the like in the lower pipe section can be conveniently extracted, and great convenience is realized.
Preferably, the inner tube is a straight tube or a stepped tube, the bottom of the inner tube is of a conical structure, a flat-bottom structure or a round-bottom structure,
and/or the outer tube is a straight tube or a stepped tube, and the bottom of the outer tube is of a conical structure, a flat-bottom structure or a round-bottom structure. The bottom of the outer tube preferably adopts a flat bottom structure, so that the centrifuge tube or the separated outer tube can be vertically placed under the condition without a test tube rack.
Compared with the prior art, the centrifugal tube with the double-layer structure provided by the invention has the advantages of compact structure, reasonable design and double-layer structure, can conveniently, safely and pollution-free separate supernatant after centrifugation is finished, can effectively avoid disturbing samples gathered at the lower layer, and can effectively store and isolate the separated supernatant, thereby effectively preventing pollution and effectively avoiding biological potential safety hazards.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings needed to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and for those skilled in the art, other related drawings can be obtained according to the drawings without inventive efforts.
Fig. 1 is a schematic structural diagram of a centrifuge tube with a double-layer structure according to an embodiment of the present invention.
Fig. 2 is a schematic structural view of an inner tube in a centrifuge tube with a double-layer structure according to an embodiment of the present invention.
Fig. 3 is a schematic structural diagram of an upper tube segment in a centrifuge tube with a double-layer structure according to an embodiment of the present invention.
Fig. 4 is a schematic structural view of a lower tube section in a centrifuge tube with a double-layer structure according to an embodiment of the present invention.
Fig. 5 is a schematic structural diagram of an outer tube in a centrifuge tube with a double-layer structure according to an embodiment of the present invention.
Fig. 6 is a view a-a of fig. 5.
Fig. 7 is a partially enlarged schematic view I of fig. 5.
Fig. 8 is a schematic structural view of a centrifuge tube with a double-layer structure according to an embodiment of the present invention, where an outer tube is in a first position.
Fig. 9 is a partially enlarged schematic view II of fig. 8.
Fig. 10 is a partially enlarged schematic view III of fig. 8.
Fig. 11 is a schematic structural view of a centrifuge tube with a double-layer structure according to an embodiment of the present invention, where an outer tube is in a second position.
Fig. 12 is a partially enlarged schematic view IV of fig. 11.
Fig. 13 is a schematic structural diagram of a centrifuge tube with a double-layer structure according to an embodiment of the present invention after separating an upper tube segment.
Fig. 14 is a partial structural schematic view of a centrifuge tube having a double-layer structure, in which a second constraining member is disposed at a second position and an annular sealing ring is constrained.
Description of the drawings
An inner pipe 100, a first inner cavity 101, a communication hole 102, a first pipe 103, a second pipe 104, an air hole 105, a first restriction member 106, a guide surface 107, a stopper surface 108, a second restriction member 109, an upper pipe 110, a lower pipe 111, a first stopper member 106, a second stopper member 104, a first stopper member, a second,
Sealing member 400, airtight member 401, connecting band 402,
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. The components of embodiments of the present invention generally described and illustrated in the figures herein may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments of the present invention without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
Referring to fig. 1 to 14, the present embodiment provides a centrifuge tube with a double-layer structure, which includes an inner tube 100 and an outer tube 200, wherein the inner tube 100 is provided with a first inner cavity 101 and a first opening, the first opening is communicated with the first inner cavity 101,
the outer tube 200 is provided with a second inner cavity 201 and a second opening, which is in communication with the second inner cavity 201,
as shown in fig. 1, 8 and 11, the outer tube 200 is sleeved outside the inner tube 100, an annular sealing ring 300 is disposed between the outer tube 200 and the inner tube 100, the annular sealing ring 300 is fixed to the outer tube 200 for implementing sliding sealing and forming a closed cavity between the outer tube 200 and the inner tube 100, the inner tube 100 is provided with a communication hole 102 for communicating the first inner cavity 101 and the second inner cavity 201, the communication hole 102 is disposed at a set distance from the bottom of the first inner cavity 101,
the outer tube 200 is provided with a seal 202 for closing said communication hole 102, as shown in figures 5, 7-13,
the outer tube 200 is configured to move from a first position to a second position relative to the inner tube 100 by an external force, and when the outer tube 200 is in the first position, a volume of a cavity formed between the outer tube 200 and the inner tube 100 is minimum, that is, a volume of the inner tube 100 inserted into the outer tube 200 is maximum, and a coincidence degree of the two is maximum, the sealing member 202 closes the communication hole 102, when the outer tube 200 moves from the first position to the second position, the sealing member 202 opens the communication hole 102 and forms a negative pressure between the outer tube 200 and the inner tube 100, and when the outer tube 200 is in the second position, a volume of a cavity formed between the outer tube 200 and the inner tube 100 is maximum.
It is understood that, in the present embodiment, the cavity volume minimum and the cavity volume maximum refer to minimum and maximum in the movable range of the outer tube 200 with respect to the inner tube 100, that is, the volume of the cavity formed between the outer tube 200 and the inner tube 100 at the second position is greater than the volume of the cavity formed between the outer tube 200 and the inner tube 100 at the first position, as shown in fig. 8 and 11, in this embodiment, by providing the inner tube 100 and the outer tube 200 such that a biological sample can be introduced into the first internal cavity 101 via the first opening, by providing the outer tube 200 with the o-ring seal 300, a closed cavity may be formed between the outer tube 200 and the inner tube 100, and when the outer tube 200 is moved relative to the inner tube 100 by an external force, the ring seal 300 moves along with the outer tube 200, and ensures a sealed state between the outer tube 200 and the inner tube 100 so as to form a negative pressure between the outer tube 200 and the inner tube 100; and the communication hole 102 may be provided at a position corresponding to the bottom of the supernatant to effectively separate the supernatant; the specific using process is as follows: initially, the outer tube 200 is in the first position, at this time, the sealing member 202 seals the communication hole 102, the volume of the cavity formed between the outer tube 200 and the inner tube 100 is minimum, the first internal cavity 101 is not communicated with the second internal cavity 201, and the centrifuge tube can be placed still or centrifuged according to a conventional use method; when the supernatant needs to be separated after standing or centrifugation, the user pulls the outer tube 200, so that the outer tube 200 moves relative to the inner tube 100, the sealing member 202 is separated from the communication hole 102, so that the first inner cavity 101 and the second inner cavity 201 are communicated through the communication hole 102, the supernatant can enter the second inner cavity 201 through the communication hole 102, and during the movement of the outer tube 200 relative to the inner tube 100, a negative pressure is formed between the outer tube 200 and the inner tube 100, so that the supernatant can be smoothly sucked into the second inner cavity 201, and when or before the outer tube 200 moves to the second position, the supernatant is completely introduced into the outer tube 200 through the communication hole 102, at this time, the required sample (and the lower sediment) is remained in the inner tube 100, the user can conveniently take the supernatant, and when the outer tube 200 is in the second position, the outer tube 200 can be separated from the inner tube 100 (i.e. in the first embodiment provided by this embodiment, the second position may be a position separated from the inner tube 100), the user may individually close the second opening of the outer tube 200 for safe and pollution-free separation and storage of the supernatant, thereby effectively preventing pollution and effectively putting an end to biological safety hazards.
In the second embodiment provided in this embodiment, the second position may also be set at a position where the outer tube 200 is not separated from the inner tube 100, and at this time, the outer tube 200 needs to be locked to the inner tube 100, and the communication hole 102 is not communicated with the outer tube 200, and the second internal cavity 201 can also be sealed, so that the purpose of separating and storing the supernatant liquid safely and without pollution can also be achieved. The centrifuging tube that two kinds of above-mentioned embodiments provided not only can utilize the convenient, safe, pollution-free separation supernatant of negative pressure after the centrifugation is accomplished to can effectively avoid the disturbance to gather in the sample of lower floor, can effectively store and keep apart the supernatant of isolating moreover, thereby effectively prevent to pollute and effectively stop biological potential safety hazard.
In this embodiment, the inner tube 100 and the outer tube 200 may be made of materials commonly used in the art, such as glass, plastic, etc., and have light transmission characteristics, which are not illustrated herein; in order to achieve a good sealing effect, at least one section of the outer diameter of the outer tube 200 is kept constant so as to be matched with the ring-shaped seal ring 300, thereby achieving a good sealing effect.
In this embodiment, the annular sealing ring 300 may be made of rubber, and the annular sealing ring 300 has a thickness set to effectively fill the space between the inner tube 100 and the outer tube 200 and achieve sealing; the o-ring 300 also has a width set so as to increase a contact area and effectively restrain the outer tube 200 such that the outer tube 200 can be linearly moved in a length direction of the inner tube 100 with respect to the inner tube 100 by the o-ring 300; to facilitate the installation of the ring seal 300, the inner wall of the outer tube 200 is configured with an annular groove for installing the ring seal 300, or the two annular protrusions 204 are provided to form an annular groove for installing the ring seal 300, as shown in fig. 7, 9 and 12.
In order to prevent contamination, in a further aspect, the centrifuge tube further includes a sealing member 400, and the sealing member 400 detachably opens/closes the first opening, so as to ensure that the first internal cavity 101 has good sealing performance, prevent contamination, and particularly, prevent the sample in the inner tube 100 from splashing during centrifugation.
In order to realize the detachable connection of the sealing component 400, the sealing component 400 has various embodiments, as a preferred embodiment, the sealing component 400 may be a rubber plug, and the rubber plug may preferably adopt a conical or truncated cone-shaped structure, so as to plug the first opening tightly by using the elasticity of the rubber plug, thereby achieving the detachable sealing effect;
as another embodiment, the sealing member 400 may be a sealing cap, which may be preferably made of plastic, the first opening is provided with an external thread 502, and the sealing cap is provided with an internal thread 501 adapted to the external thread 502 so as to effectively close/open the first opening, as shown in fig. 1 to 3.
In this embodiment, in order to detachably fix the outer pipe 200 at the first position, in a further aspect, the inner wall of the outer pipe 200 is provided with an internal thread 501, the annular sealing ring 300 is disposed below the internal thread 501, the outer wall of the inner pipe 100 is provided with an external thread 502 matched with the internal thread 501 at a position set apart from the first opening, the outer pipe 200 is fixed at the first position by the matching of the internal thread 501 and the external thread 502, so as to lock the outer pipe 200 at the set first position, as shown in fig. 1-3 and 8, in this embodiment, in order to process the external thread 502 on the inner pipe 100, the inner pipe 100 may be a stepped pipe, as shown in fig. 2, so that the inner pipe 100 includes two pipe sections with different outer diameters, namely, a first pipe section 103 and a second pipe section 104, and the outer diameter of the second pipe section 104 is smaller than the outer diameter of the first pipe section 103, two external threads 502 may be respectively disposed on the upper and lower ends of the second pipe 104, the upper external thread 502 is used for connecting the sealing cap, and the lower external thread 502 is used for connecting the outer pipe 200, so as to lock the outer pipe 200 at the first position, as shown in fig. 1, 2 and 8, a certain distance may be provided between the two external threads 502, so that a user can hold or apply force.
In order to make the supernatant in the inner tube 100 enter the outer tube 200 without contamination under the action of the negative pressure, in a further embodiment, the centrifuge tube further comprises an air hole 105 and an air-tight part 401 for sealing the air hole 105,
the air hole 105 may be disposed on a sidewall of the inner tube 100 and is communicated with the first inner cavity 101, and the air hole 105 is located above the outer tube 200; the air hole 105 may also be provided in the sealing member 400, such as in the sealing cap,
and airtight part 401 can be rubber buffer or airtight lid etc. through setting up gas pocket 105 and sealing airtight part 401 of gas pocket 105 for utilize the in-process of negative pressure separation supernatant, can needn't open whole sealing part 400, only need open gas pocket 105, can make the first cavity of inner tube 100 be linked together with the atmosphere, when guaranteeing that the supernatant is smooth gets into the second cavity under the effect of negative pressure, make first inside cavity 101 have good leakproofness, thereby effectively prevent to take place the pollution problem.
Preferably, as shown in fig. 1 and 2, the air hole 105 may be disposed on the first pipe segment 103, and the airtight member 401 may be provided with a flexible connection strip 402, and the other end of the connection strip 402 is movably connected (e.g., hinged) to the sealing member 400, so that the airtight member 401 and the sealing member 400 can be connected together, when the sealing member 400 is opened, the airtight member 401 can be used as a support to prevent the sealing member 400 from being separated from the centrifuge tube, and when the airtight member 401 is opened, the sealing member 400 can be used as a support to prevent the airtight member 401 from being separated from the centrifuge tube, thereby being more convenient to use.
In this embodiment, the sealing member 202 is fixed to the outer tube 200 and drives the communication hole 102 to open/close following the rotation/movement of the outer tube 200, so in this embodiment, the sealing member 202 has various embodiments, and as a preferable mode, as shown in fig. 5, 6, 8, and 10, the sealing member 202 may be an elastic gasket disposed on the inner wall of the outer tube 200, and when the outer tube 200 is located at the first position, the elastic gasket is located outside the communication hole 102 and presses the outer wall of the inner tube 100 around the communication hole 102; the shape of the elastic pad may be adapted to the shape of the communication hole 102, for example, when the communication hole 102 is a circular hole, the elastic pad may preferably adopt a circular or rectangular structure.
As another embodiment, the sealing member 202 may also be an elastic protrusion disposed on the inner wall of the outer tube 200, and when the outer tube 200 is located at the first position, the elastic protrusion is snapped into the communication hole 102 and closes the communication hole 102, and the shape of the elastic protrusion may be adapted to the shape of the communication hole 102, for example, when the communication hole 102 is a circular hole, the elastic protrusion may be a hemispherical protrusion, a columnar protrusion, or the like; by providing the sealing member 202 as an elastic washer and/or an elastic protrusion, the sealing member 202 is driven to elastically compress by the pressing force between the outer pipe 200 and the inner pipe 100 and press the communication hole 102, thereby achieving the purpose of closing the communication hole 102, and when the outer pipe 200 rotates and/or moves relative to the inner pipe 100, the sealing member 202 may be driven to synchronously move and thereby move relative to the communication hole 102, so that the sealing member 202 and the communication hole 102 are staggered from each other, thereby achieving the purpose of driving the communication hole 102 to open/close according to the rotation and/or movement of the outer pipe 200.
It will be appreciated that the sealing element 202 may also be a combination of a resilient projection for insertion into the communication hole 102 and a resilient gasket for sealing around the communication hole 102, which is advantageous for enhancing the sealing effect.
In a more perfect scheme, in order to equalize the stress between the outer tube 200 and the inner tube 100, the centrifugal tube comprises at least two sealing members 202, and the sealing members 202 are uniformly distributed along the circumferential direction of the inner wall of the outer tube 200; for example, when two sealing members 202 are included, as shown in fig. 5 and fig. 6, the two sealing members 202 may be respectively and symmetrically disposed on two sides of the outer tube 200 so as to be stressed in a balanced manner, and when three sealing members 202 are included, the three sealing members 202 may be respectively and uniformly distributed along the circumferential direction of the outer tube 200, and form an included angle of 120 degrees with each other so as to be stressed in a balanced manner; in this embodiment, by providing a plurality of sealing members 202 along the circumferential direction of the outer tube 200, the stress distribution between the inner tube 100 and the outer tube 200 along the circumferential direction is uniform, a stable and reliable sealing pressure at the communication hole 102 is ensured, and sealing is facilitated, and by matching with the annular sealing ring 300, the stress distribution between the outer tube 200 and the inner tube 100 along the length direction is more uniform, so that the outer tube 200 is restrained from moving linearly to the second position relative to the inner tube 100.
In the present embodiment, when the second position is configured at the position where the outer tube 200 is not separated from the inner tube 100, the outer tube 200 should be locked and limited at the second position, and it is required to effectively close the space between the outer tube 200 and the inner tube 100, specifically, as shown in fig. 2, 8-13, the outer wall of the inner tube 100 is configured with the first restriction member 106, and the first restriction member 106 is disposed at the second position, the first restriction member 106 is configured with the guide surface 107 and the limiting surface 108, wherein,
the guide surface 107 faces upward of the inner pipe 100 for guiding the annular seal ring 300 to move in a direction away from the first opening, as shown in fig. 10 or 12; the limiting surface 108 faces the lower part of the inner pipe 100 and is used for limiting the movement of the annular sealing ring 300 along the direction close to the first opening; as shown in fig. 10 or 12, the communication hole 102 is located below the first restriction member 106, and the width of the annular seal 300 is larger than the maximum distance between the communication hole 102 and the first restriction member 106; with such a structural design, by configuring the first restriction member 106, the annular seal ring 300 can be effectively restricted and limited, so as to achieve the purpose of restricting the outer tube 200 at the second position, and because the width of the annular seal ring 300 is greater than the maximum distance between the communication hole 102 and the first restriction member 106, when the annular seal ring 300 moves below the first restriction member 106, the annular seal ring 300 can completely cover the communication hole 102, so as to achieve the purpose of closing the communication hole 102, so that the cavity between the inner tube 100 and the outer tube 200 is kept in a closed state, thereby effectively preventing the supernatant from leaking from the communication hole 102; in addition, since a closed cavity is formed between the inner pipe 100 and the outer pipe 200, the outer pipe 200 is not moved relative to the inner pipe 100 any more due to the pressure, thereby effectively preventing the separation of the outer pipe 200 from the inner pipe 100.
Preferably, the guide surface 107 may be a slope or an arc surface to guide the outer tube 200 to move to the second position, and/or the stopper surface 108 may be preferably flat and perpendicular to the central axis of the inner tube 100, as shown in fig. 8 to 13, to stably limit the annular sealing ring 300 to the second position.
In the present embodiment, the first restriction member 106 has various embodiments, and preferably, the first restriction member 106 may have an annular structure and is disposed along the circumferential direction of the inner tube 100, as shown in fig. 8 to 13, in the present embodiment, the first restriction member 106 is an annular boss disposed on the outer wall of the inner tube 100; in another embodiment, a plurality of first constraint parts 106 may be uniformly arranged along the circumferential direction of the inner tube 100, that is, each first constraint part 106 is arranged on the inner tube 100 with a gap along the circumferential direction, which is not only beneficial to limiting and locking the annular seal ring 300, thereby achieving the purpose of locking the outer tube 200, but also beneficial to the convenience of use because the seal 202 may pass through the arrangement position of the first constraint part 106 through the gap between two adjacent first constraint parts 106 during the movement of the outer tube 200 relative to the inner tube 100 without interfering with each other; when the first constraining member 106 is a ring-shaped structure, the lower edge of the sealing member 202 is a bevel or arc 203 to guide the sealing member 202 to pass through the first constraining member 106 smoothly.
In a further aspect, to enhance the locking effect, the centrifugal tube further includes a second constraining member 109, the second constraining member 109 is disposed on the outer wall of the inner tube 100 and located below the first constraining member 106, a distance between the first constraining member 106 and the second constraining member 109 is greater than or equal to a width of the annular sealing ring 300, the first constraining member 106 and the second constraining member 109 are respectively used for constraining the upper end and the lower end of the annular sealing ring 300, as shown in fig. 14, by disposing the second constraining member 109 and forming a fit with the first constraining member 106, when the outer tube 200 moves to the set second position, the annular sealing ring 300 is just clamped between the first constraining member 106 and the second constraining member 109, thereby achieving the purpose of locking the outer tube 200.
The second restriction member 109 may have the same structure as the first restriction member 106 and may be arranged symmetrically with respect to the first restriction member 106, as shown in fig. 14, and will not be described in detail herein.
In a more sophisticated embodiment, the inner tube 100 may be a straight tube or a stepped tube (e.g., the combination of the first tube segment 103 and the second tube segment 104 mentioned above), the bottom of the inner tube 100 may be a tapered structure, a flat-bottom structure or a round-bottom structure,
and/or, the outer tube 200 may be a straight tube or a stepped tube, and the bottom of the outer tube 200 may be a tapered structure, a flat bottom structure or a round bottom structure, as shown in fig. 1 and 2, in this embodiment, the bottom of the outer tube 200 preferably adopts a flat bottom structure, so that the centrifuge tube or the separated outer tube 200 can be vertically placed without a test tube rack.
Example 2
In order to facilitate the easy removal of sediment at the lower part of the inner tube 100 after centrifugation, the main difference between this embodiment 2 and the above embodiment 1 is that in the centrifuge tube provided in this embodiment, the inner tube 100 comprises an upper tube segment 110 (the upper tube segment 110 can be formed by the first tube segment 103 and the second tube segment 104 described in embodiment 1) and a lower tube segment 111, the lower end of the upper tube segment 110 is integrally connected with the upper end of the lower tube segment 111 by a screw thread, and the outer diameters of the upper tube segment 110 and the lower tube segment 111 are the same, as shown in fig. 2-4;
the lower end of the lower tube section 111 is closed, and the communication hole 102 and the first restriction member 106 are respectively formed at the lower tube section 111, as shown in fig. 4,
the first opening is formed at the upper end of the upper pipe section 110, as shown in fig. 3, in this embodiment, the inner pipe 100 is integrally connected by screwing the upper pipe section 110 and the lower pipe section 111, and the outer diameters of the upper pipe section 110 and the lower pipe section 111 are maintained to be the same, so that a good sealing effect is obtained when the annular sealing ring 300 moves along the outer wall of the inner pipe 100; because the sediments and the like in the inner pipe 100 are gathered in the lower pipe section 111, after the separation work of the supernatant is completed, a user can manually separate the upper pipe section 110 from the lower pipe section 111, and the lower pipe section 111 is connected with the outer pipe 200 into a whole, so that the sediments and the like in the lower pipe section 111 can be conveniently extracted, and the separation is very convenient; and the lower pipe section 111 and the outer pipe 200 can be recycled as a whole, so that pollution is effectively prevented, and potential biological safety hazards are effectively eliminated.
In order to make the outer diameters of the upper pipe section 110 and the lower pipe section 111 the same, as an embodiment, as shown in fig. 3 and 4, the inner wall of the upper end of the lower pipe section 111 is provided with a first annular groove, the first annular groove is provided with an internal thread 501, correspondingly, the outer wall of the lower end of the upper pipe section 110 is provided with a second annular groove, the second annular groove is provided with an external thread 502, the connection between the upper pipe section 110 and the lower pipe section 111 is realized through the matching of the external thread 502 and the internal thread 501, and the outer diameters of the upper pipe section 110 and the lower pipe section 111 at the joint are ensured to be.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention.
Claims (10)
1. A centrifuge tube with a double-layer structure is characterized by comprising an inner tube, wherein the inner tube is provided with a first inner cavity and a first opening, the first opening is communicated with the first inner cavity,
an outer tube having a second interior cavity and a second opening in communication with the second interior cavity,
the outer pipe is sleeved outside the inner pipe, an annular sealing ring is arranged between the outer pipe and the inner pipe, the annular sealing ring is fixed on the outer pipe and used for realizing sliding sealing and forming a closed cavity between the outer pipe and the inner pipe, the inner pipe is provided with a communication hole used for communicating the first inner cavity and the second inner cavity, the communication hole is arranged at a set distance from the bottom of the first inner cavity,
the outer tube is provided with a sealing member for closing the communication hole,
the outer tube is adapted to move from a first position to a second position relative to the inner tube, wherein,
when the outer pipe is at the first position, the volume of a cavity formed between the outer pipe and the inner pipe is minimum, the sealing piece seals the communication hole, when the outer pipe moves from the first position to the second position, the sealing piece opens the communication hole, negative pressure is formed between the outer pipe and the inner pipe, and when the outer pipe is at the second position, the volume of the cavity formed between the outer pipe and the inner pipe is maximum.
2. The centrifuge tube of double-layer structure of claim 1, further comprising a sealing member for detachably opening/closing the first opening,
the sealing component is a rubber plug,
or, the sealing part is a sealing cover, the first opening is provided with an external thread, and the sealing cover is provided with an internal thread matched with the external thread.
3. The centrifuge tube with the double-layer structure according to claim 1, wherein an inner thread is arranged on the inner wall of the outer tube, the annular sealing ring is arranged below the inner thread, an outer thread matched with the inner thread is arranged at a position, set away from the first opening, on the outer wall of the inner tube, and the outer tube is fixed at the first position through the matching of the inner thread and the outer thread.
4. The centrifuge tube with double-layer structure of claim 2, further comprising an air hole and an air-tight member for sealing the air hole,
the air hole is arranged on the side wall of the inner tube and communicated with the first inner cavity, the air hole is positioned above the outer tube, or the air hole is arranged on the sealing part,
the airtight component is a rubber plug or an airtight cover.
5. The centrifuge tube with a double-layer structure according to any one of claims 1 to 4, wherein the sealing member is an elastic gasket arranged on the inner wall of the outer tube, and when the outer tube is located at the first position, the elastic gasket is located outside the communication hole and presses the outer wall of the inner tube around the communication hole;
and/or, the sealing member is an elastic bulge arranged on the inner wall of the outer pipe, and when the outer pipe is located at the first position, the elastic bulge is clamped into the communication hole and seals the communication hole.
6. The centrifuge tube with double-layer structure as claimed in claim 5, wherein the centrifuge tube comprises at least two sealing members, and the sealing members are uniformly distributed along the circumferential direction of the inner wall of the outer tube.
7. The dual-layer centrifuge tube of any of claims 1-4, wherein the inner tube outer wall is configured with a first restraining member and the first restraining member is disposed at the second location, the first restraining member is configured with a guide surface and a stop surface, wherein,
the guide surface faces upward of the inner pipe and guides the annular seal ring to move in a direction away from the first opening,
the limiting surface faces the lower part of the inner pipe and is used for limiting the annular sealing ring to move along the direction close to the first opening;
the communicating hole is positioned below the first restraining component, and the width of the annular sealing ring is larger than the maximum distance between the communicating hole and the first restraining component.
8. The centrifuge tube with the double-layer structure according to claim 7, wherein the guide surface is a slope or an arc surface, and/or the limiting surface is a plane and is perpendicular to the central axis of the inner tube.
9. The centrifuge tube having a double-layered structure according to claim 7, wherein the first restriction member has a ring-shaped structure and is disposed along a circumferential direction of the inner tube,
or, the inner pipe comprises a plurality of first constraint parts which are uniformly distributed along the circumferential direction of the inner pipe.
10. The centrifuge tube with the double-layer structure according to claim 7, further comprising a second restriction member disposed on the outer wall of the inner tube and located below the first restriction member, wherein the distance between the first restriction member and the second restriction member is greater than or equal to the width of the annular sealing ring, and the first restriction member and the second restriction member are respectively used for restricting the upper end and the lower end of the annular sealing ring.
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| CN202010872051.9A CN111841679B (en) | 2020-08-26 | 2020-08-26 | Centrifuge tube with double-layer structure |
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| CN202010872051.9A CN111841679B (en) | 2020-08-26 | 2020-08-26 | Centrifuge tube with double-layer structure |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113877650A (en) * | 2021-11-10 | 2022-01-04 | 美东汇成生命科技(昆山)有限公司 | Centrifuging tube that practicality is high |
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