CN111838681A - Nutritional formulation composition and method of making same - Google Patents

Nutritional formulation composition and method of making same Download PDF

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CN111838681A
CN111838681A CN202010785095.8A CN202010785095A CN111838681A CN 111838681 A CN111838681 A CN 111838681A CN 202010785095 A CN202010785095 A CN 202010785095A CN 111838681 A CN111838681 A CN 111838681A
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赵捷
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Guangzhou Hangke Biotechnology Co ltd
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Abstract

The invention belongs to the technical field of medical health products, and particularly relates to a nutritional preparation composition and a preparation method thereof. The nutritional preparation composition comprises the following components in parts by weight: 3-110 parts of hydrolyzed small-molecule protein powder, 0.3-48 parts of edible fungi polysaccharide peptide, 0.3-80 parts of gamma-aminobutyric acid and 0.3-80 parts of beta-nicotinamide mononucleotide. The nutritional preparation composition provides basic nutrition with small molecular protein, improves immunity with polysaccharide peptide to improve immunity, solves degenerative disease problem with nicotinamide mononucleotide, and improves sleep by ingesting GABA; therefore, the traditional Chinese medicine composition can improve the insufficient digestion and absorption functions caused by systemic diseases and partial immune defects, and solve the problems of insufficient caloric intake and malnutrition caused by degenerative change. The preparation method is easy to implement and low in cost. In a word, the nutritional preparation composition and the preparation method of the nutritional preparation composition provided by the invention have great application values in the field of medical and health-care products.

Description

Nutritional formulation composition and method of making same
Technical Field
The invention belongs to the technical field of medical health care products, and particularly relates to a nutritional preparation composition and a preparation method thereof.
Background
Food is heated through oral cavity, and after entering stomach, gastric mucosa secretes gastrin, stimulates parietal cells of gastric glands to secrete hydrochloric acid and main cells to secrete pepsinogen. Inactive pepsinogen is converted to pepsin upon activation. Pepsin cannot break down a peptide chain into single amino acids, but can only hydrolyze peptide bonds connecting some amino acids (such as peptide chains between tyrosine and phenylalanine). Pepsin hydrolyses food proteins into polypeptide fragments of varying sizes, which flow with chyme into the small intestine, triggering secretion of secretin by the small intestine. Secretin stimulates the pancreas to secrete bicarbonate into the small intestine, neutralizes hydrochloric acid in the stomach contents, and has a pH of about 7.0. Meanwhile, the duodenum of the upper small intestine releases the enteropancreatin peptide to stimulate the pancreas to secrete a series of trypsinogen, including trypsinogen, chymotrypsinogen, procarboxypeptidase and the like. In the duodenum, trypsinogen is converted into active trypsin through enterokinase secreted by small intestine cells, and catalyzes activation of other pancreatin. These pancreatic enzymes hydrolyze the peptide fragment mixture to shorter peptides, respectively. The short peptide generated in the small intestine is degraded from the C terminal of the peptide by carboxypeptidase, and is degraded from the N terminal by aminopeptidase, so that the protein in the chyme is degraded into a mixture of amino acids (or amino acids and small peptides) through the combined catalysis of a plurality of enzymes, and then is absorbed by intestinal mucosa epithelial cells and enters the body. Free amino acids enter the blood circulation and enter the body, i.e. the complete digestion and absorption of proteins is all in the small intestine. The small intestine contains pancreas secreted trypsin, trypsin chymotrypsin, small intestine secreted aminopeptidase, dipeptidase, etc. and polypeptide chain is hydrolyzed into small peptide and amino acid step by step in various modes.
Malabsorption syndrome is a syndrome caused by a disorder of absorption of nutrients by the small intestine and is clinically classified into two types, primary and secondary. Primary malabsorption syndrome is caused by a defect in the small intestinal mucosa that affects substance absorption and re-esterification of fatty acids within the cell. Secondary malabsorption syndrome is found in dyspepsia or malabsorption caused by a variety of factors, the main factors being: liver, biliary, pancreatic disease and a deficiency of pancreatic digestive enzymes; after the gastrectomy, short bowel syndrome, the change of the pH value of the digestive tract, small bowel diseases or mesenteric diseases and the like can all influence the absorption function and the digestion function of the small intestine; the digestive absorption function insufficiency caused by systemic diseases and partial immune defects comprises gliosis and tropical sprue.
Symptoms of malabsorption syndrome in the elderly are often atypical and manifest primarily as abdominal distension, diarrhea, anemia, or bone pain. The elderly are prone to malabsorption syndrome, the main cause of which is related to the elderly, and the changes are more pronounced in the stomach, small intestine and pancreas. In the elderly, the intestinal trichome becomes short, the absorption area is reduced, the pancreas is gradually atrophied, and the connective tissue of interstitial fibers is proliferated, so that the changes cause the overgrowth of small intestinal bacteria, the diverticulitis and diverticulosis of the digestive tract are obviously increased, and in addition, the insufficient heat intake and the malnutrition caused by the degenerative change can cause or aggravate malabsorption syndrome.
Wherein the malabsorption syndrome can be precipitated or aggravated by the insufficiency of digestive absorption caused by systemic diseases and partial immune deficiency, and by the insufficient caloric intake and malnutrition caused by degenerative changes.
Therefore, it is highly desirable to provide a drug or health product to improve the digestive absorption insufficiency caused by systemic diseases and partial immune deficiency, and to solve the problems of insufficient caloric intake and malnutrition caused by degenerative changes.
Disclosure of Invention
The invention aims to provide a nutritional preparation which can improve the insufficient digestion and absorption functions caused by systemic diseases and partial immune defects and solve the problems of insufficient caloric intake and malnutrition caused by degenerative change. The nutritional preparation uses small molecular protein to supply basic nutrition, uses polysaccharide peptide to improve immunity of human body, and uses nicotinamide mononucleotide to solve degenerative disease.
Specifically, the first aspect of the invention provides a nutritional formulation composition, which comprises the following components in parts by weight:
Figure BDA0002621659730000021
preferably, the nutritional formulation composition comprises the following components in parts by weight:
Figure BDA0002621659730000022
further preferably, the nutritional formulation composition comprises the following components in parts by weight:
Figure BDA0002621659730000031
preferably, the nutritional formulation composition further comprises vitamins selected from the group consisting of any one or more of the following in combination: vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, vitamin H, vitamin P, vitamin PP, vitamin M, vitamin T and vitamin U.
It is worth supplementing that the nutritional formulation composition is a solid formulation or a liquid formulation.
And, the functional mechanism of the nutritional formulation composition is as follows:
digestive and absorptive dysfunction often puts the body in a state of malnutrition when nutritional support is necessary. The hydrolyzed small molecule protein powder in the nutritional preparation provided by the invention is rich in essential amino acids of human body and is an important component of human protein nutrition, and meanwhile, the small molecule protein can be rapidly absorbed by human intestinal tracts, so that protein nutrition required by human body can be rapidly supplemented, and finally, the improvement of the nutritional status of patients with refractory malabsorption syndrome is realized.
Wherein, the edible fungus extract contains polysaccharide peptide, which can enhance the activity of T cells, B cells, NK cells and mononuclear macrophages and improve the immunity of the organism, thereby solving the problem of insufficient digestion and absorption functions caused by systemic diseases and partial immune defects.
Wherein the use of β -Nicotinamide Mononucleotide (NMN) increases β -nicotinamide mononucleotide levels in the body, NMN being a precursor for NAD + synthesis in the human body, thereby increasing NAD + levels, thereby increasing mitochondrial Oxygen Consumption Rates (OCR), thereby promoting mitochondrial fusion, reducing fission trends, enabling mitochondria to produce longer mitochondria in hippocampal subregions, thereby improving mitochondrial respiratory function, enhancing energy metabolism, improving insulin sensitivity and lipid distribution in plasma, and improving ocular function; beta-nicotinamide mononucleotide can prevent age-related gene expression changes in a tissue-specific manner and enhance mitochondrial oxidative metabolism in skeletal muscle, at least partially mediate degenerative changes, and has neuro-sedating, anxiolytic effects.
Among them, gamma-aminobutyric acid (GABA) is an inhibitory transmission substance of the central nervous system, and is one of the most important neurotransmitters in brain tissues, and functions to reduce neuronal activity, prevent overheating of nerve cells, and GABA binds to and activates anxiolytic brain receptors, and then synergistically acts with other active substances, preventing anxiety-related information from reaching the cranial nerve center. GABA synthetic neurons are distributed in nuclei of brainstem and diencephalon and in projection neurons, and play a role in inhibiting cerebral cortex projection. Researches find that the sub-health insomnia is mainly caused by abnormal activities of GABA and Glu, so that the GABA taken by a human body is beneficial to falling asleep more quickly, and the effects of improving sleep, lowering blood pressure, resisting anxiety, relaxing mood, improving memory and the like are achieved.
In a second aspect of the present invention, there is provided a method for preparing the nutritional formulation composition according to the first aspect, specifically comprising the steps of:
premixing the hydrolyzed small molecular protein powder and the edible fungi polysaccharide peptide for at least 10 minutes, then adding the gamma-aminobutyric acid and the beta-nicotinamide mononucleotide, and stirring and mixing for at least 10 minutes to prepare the nutritional preparation composition.
Mixing in batches according to the above steps can increase the absorption area of the nutritional formulation, thereby improving the absorption stability.
Preferably, in the preparation method of the nutritional preparation composition, the preparation step of the hydrolyzed small molecule protein powder comprises the following steps:
s1: taking a protein raw material, adding production water, and mixing; the protein material is selected from any one or combination of more of the following: soybean, corn, ovalbumin, wheat, fish protein, milk;
s2: adding protease for enzymolysis;
s3: enzyme deactivation;
s4: performing membrane filtration, collecting filtrate, and vacuum concentrating;
s5: sterilizing, and spray drying to obtain the hydrolyzed small molecular protein powder.
Further preferably, in the above method for preparing a nutritional formulation composition, the conditioning conditions are ph 7.3-7.8; the temperature of the enzymolysis is 45-55 ℃; the temperature for enzyme deactivation is 110-120 ℃; the sterilization is instantaneous sterilization, and the temperature is 120-130 ℃; the inlet temperature of the spray drying is 170 ℃ and the outlet temperature is 80 ℃.
Preferably, in the above method for preparing a nutritional formulation composition, the step of preparing the polysaccharide peptide of edible fungi comprises:
s1: adding the polysaccharide peptide raw material into production water, and dissolving; the polysaccharide peptide feedstock is selected from any one or a combination of: lucid ganoderma, cordyceps sinensis, shiitake mushroom, hericium erinaceus, agaricus blazei, flammulina velutipes and yeast powder;
s2: performing membrane filtration, collecting filtrate, and vacuum concentrating;
s3: spray drying to obtain the edible fungus polysaccharide peptide.
Further preferably, in the above method for preparing a nutritional formulation composition, the vacuum concentration conditions are: the concentration temperature is 60-85 ℃, and the vacuum degree is-0.06-0.08 Mpa; the inlet temperature of the spray drying is 180 ℃, and the outlet temperature is 90 ℃.
Wherein, the beta-Nicotinamide Mononucleotide (NMN) can be purchased from the market or prepared by the method known in the prior art, for example, the beta-nicotinamide mononucleotide product is obtained by biological construction by taking ribose, nicotinamide and adenosine disodium triphosphate as reaction raw materials.
Wherein, the gamma-aminobutyric acid (GABA) can be purchased from the market or prepared by the method known in the prior art, for example, the GABA is prepared by fermenting glutamic acid or derivatives thereof as raw materials by using food safety level microorganisms such as yeast, lactobacillus and aspergillus, and the like, and for example, the GABA can be prepared by a biological purification method and a chemical synthesis method.
Compared with the prior art, the invention has the following technical advantages:
firstly, the nutritional preparation composition of the invention supplies basic nutrition by using small molecular protein, improves immunity by using polysaccharide peptide so as to improve immunity of immune human body, solves the problem of degenerative disease by using nicotinamide mononucleotide, and improves sleep by taking GABA; the comprehensive efficacy of the nutritional preparation composition can improve the insufficient digestion and absorption function caused by systemic diseases and partial immune defects, and solve the problems of insufficient caloric intake and malnutrition caused by degenerative changes. And secondly, the preparation method of the nutritional preparation composition provided by the invention is easy to implement and low in cost.
Therefore, the nutritional preparation composition and the preparation method of the nutritional preparation composition provided by the invention have great application values in the field of medical and health-care products.
Drawings
FIG. 1 is a flow chart illustrating the steps of preparing hydrolyzed small molecule protein powder in a method of preparing a nutritional formulation composition according to a preferred embodiment of the present invention;
fig. 2 is a flow chart illustrating steps of preparing an edible fungus polysaccharide peptide in a method of preparing a nutritional formulation composition according to a preferred embodiment of the present invention.
Detailed Description
The present invention will be further illustrated with reference to the following specific examples, but the present invention is not limited to the following examples. All the steps in the method are conventional steps if no special description is provided; the starting materials and the equipment can be obtained from public commercial sources without specific descriptions.
The nutritional formulation composition according to the first aspect, comprising the following components in parts by weight:
Figure BDA0002621659730000061
in a preferred embodiment, the nutritional formulation composition further comprises vitamin a, vitamin B, vitamin C, vitamin D, vitamin E and vitamin PP.
In a preferred embodiment, the nutritional formulation composition further comprises vitamin C and vitamin D.
In a preferred embodiment, the nutritional formulation composition further comprises vitamin a, vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, vitamin H, vitamin P, vitamin PP, vitamin M, vitamin T and vitamin U.
A method of preparing a nutritional formulation composition according to the second aspect, comprising the steps of:
premixing the hydrolyzed small molecular protein powder and the edible fungi polysaccharide peptide for at least 10 minutes, then adding the gamma-aminobutyric acid and the beta-nicotinamide mononucleotide, and stirring and mixing for at least 10 minutes to prepare the nutritional preparation composition.
In a preferred embodiment, the preparation step of the hydrolyzed small molecule protein powder comprises the following steps:
s1: taking a protein raw material, adding production water, and mixing; the protein material is selected from any one or combination of more of the following: soybean, corn, ovalbumin, wheat, fish protein, milk;
s2: adding protease for enzymolysis;
s3: enzyme deactivation;
s4: performing membrane filtration, collecting filtrate, and vacuum concentrating;
s5: sterilizing, and spray drying to obtain the hydrolyzed small molecular protein powder.
In a further preferred embodiment, the conditioning conditions are ph 7.3-7.8; the temperature of the enzymolysis is 45-55 ℃; the temperature for enzyme deactivation is 110-120 ℃; the sterilization is instantaneous sterilization, and the temperature is 120-130 ℃; the inlet temperature of the spray drying is 170 ℃ and the outlet temperature is 80 ℃.
In a preferred embodiment, the step of preparing the polysaccharide peptide of the edible fungi comprises:
s1: adding the polysaccharide peptide raw material into production water, and dissolving; the polysaccharide peptide feedstock is selected from any one or a combination of: lucid ganoderma, cordyceps sinensis, shiitake mushroom, hericium erinaceus, agaricus blazei, flammulina velutipes and yeast powder;
s2: performing membrane filtration, collecting filtrate, and vacuum concentrating;
s3: spray drying to obtain the edible fungus polysaccharide peptide.
In a further preferred embodiment, the vacuum concentration conditions are: the concentration temperature is 60-85 ℃, and the vacuum degree is-0.06-0.08 Mpa; the inlet temperature of the spray drying is 180 ℃, and the outlet temperature is 90 ℃.
Example 1
This example prepares a nutraceutical composition comprising the following components in parts by weight:
hydrolyzed small molecule protein powder 5 parts
Edible mushroom polysaccharide peptide 1 part
48 parts of gamma-aminobutyric acid
15 parts of beta-nicotinamide mononucleotide.
Wherein, the preparation of the hydrolyzed small molecule albumen powder with reference to the attached figure 1 comprises the following steps:
s1: taking corn powder, adding production water, and mixing pulp at a pH value of 7.6;
s2: adding protease, and performing enzymolysis at 50 deg.C for 3 hr;
s3: inactivating the enzyme at 113 ℃;
s4: performing membrane filtration, collecting filtrate, and vacuum concentrating;
s5: instantly sterilizing at 120 deg.C, and spray drying (inlet temperature is 170 deg.C, outlet temperature is 80 deg.C) to obtain hydrolyzed small molecule protein powder.
Wherein, the preparation of the edible fungus polysaccharide peptide with reference to the attached figure 2 comprises the following steps:
s1: dissolving Agaricus blazei Murill powder in water;
s2: performing membrane filtration, collecting filtrate, and vacuum concentrating; wherein the vacuum concentration conditions are as follows: the concentration temperature is 72 ℃, and the vacuum degree is-0.06 Mpa;
s3: spray drying (inlet temperature is 180 ℃, outlet temperature is 90 ℃) to obtain the edible fungus polysaccharide peptide.
Among them, gamma-aminobutyric acid and beta-nicotinamide mononucleotide were purchased from Merck.
Example 2
This example prepares a nutraceutical composition comprising the following components in parts by weight:
Figure BDA0002621659730000081
wherein, the preparation of the hydrolyzed small molecule albumen powder with reference to the attached figure 1 comprises the following steps:
s1: adding egg albumin into production water, and mixing at pH 7.8;
s2: adding protease, and performing enzymolysis at 54 deg.C for 3 hr;
s3: inactivating the enzyme at 120 ℃;
s4: performing membrane filtration, collecting filtrate, and vacuum concentrating;
s5: instantly sterilizing at 128 deg.C, and spray drying (inlet temperature is 170 deg.C, outlet temperature is 80 deg.C) to obtain hydrolyzed small molecule protein powder.
Wherein, the preparation of the edible fungus polysaccharide peptide with reference to the attached figure 2 comprises the following steps:
s1: dissolving Ganoderma powder in water;
s2: performing membrane filtration, collecting filtrate, and vacuum concentrating; wherein the vacuum concentration conditions are as follows: the concentration temperature is 80 ℃, and the vacuum degree is-0.07 Mpa;
s3: spray drying (inlet temperature is 180 ℃, outlet temperature is 90 ℃) to obtain the edible fungus polysaccharide peptide.
Wherein, gamma-aminobutyric acid and beta-nicotinamide mononucleotide are purchased from Merck company; vitamin C, D, E was purchased from Zhejiang medicine.
Example 3
This example prepares a nutraceutical composition comprising the following components in parts by weight:
15 parts of hydrolyzed micromolecular protein powder
Edible mushroom polysaccharide peptide 3 parts
56 parts of gamma-aminobutyric acid
30 parts of beta-nicotinamide mononucleotide
Wherein, the preparation of the hydrolyzed small molecule albumen powder with reference to the attached figure 1 comprises the following steps:
s1: adding water for production into soybean powder, and mixing at pH 7.8;
s2: adding protease, and performing enzymolysis at 55 deg.C for 3 hr;
s3: inactivating the enzyme at 110 ℃;
s4: performing membrane filtration, collecting filtrate, and vacuum concentrating;
s5: instantly sterilizing at 130 deg.C, and spray drying (inlet temperature is 170 deg.C, outlet temperature is 80 deg.C) to obtain hydrolyzed small molecule protein powder.
Wherein, the preparation of the edible fungus polysaccharide peptide with reference to the attached figure 2 comprises the following steps:
s1: taking Hericium erinaceus powder, adding production water, and dissolving;
s2: performing membrane filtration, collecting filtrate, and vacuum concentrating; wherein the vacuum concentration conditions are as follows: the concentration temperature is 85 ℃, and the vacuum degree is-0.06 Mpa;
s3: spray drying (inlet temperature is 180 ℃, outlet temperature is 90 ℃) to obtain the edible fungus polysaccharide peptide.
Among them, gamma-aminobutyric acid and beta-nicotinamide mononucleotide were purchased from Merck.
The embodiments of the present invention have been described in detail, but the embodiments are merely examples, and the present invention is not limited to the embodiments described above. Any equivalent modifications and substitutions to those skilled in the art are also within the scope of the present invention. Accordingly, equivalent changes and modifications made without departing from the spirit and scope of the present invention should be covered by the present invention.

Claims (9)

1. The nutritional preparation composition is characterized by comprising the following components in parts by weight:
Figure FDA0002621659720000011
2. the nutritional formulation composition according to claim 1, comprising the following components in parts by weight:
Figure FDA0002621659720000012
3. the nutritional formulation composition according to claim 1, comprising the following components in parts by weight:
Figure FDA0002621659720000013
4. the nutritional formulation composition according to claim 1, further comprising vitamins selected from the group consisting of any one or more of the following: vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, vitamin H, vitamin P, vitamin PP, vitamin M, vitamin T and vitamin U.
5. A method of preparing the nutritional formulation composition of claim 1, comprising the steps of:
premixing the hydrolyzed small molecular protein powder and the edible fungi polysaccharide peptide for at least 10 minutes, then adding the gamma-aminobutyric acid and the beta-nicotinamide mononucleotide, and stirring and mixing for at least 10 minutes to prepare the nutritional preparation composition.
6. The preparation method of claim 5, wherein the preparation step of the hydrolyzed small molecule protein powder comprises the following steps:
s1: taking a protein raw material, adding production water, and mixing; the protein material is selected from any one or combination of more of the following: soybean, corn, ovalbumin, wheat, fish protein, milk;
s2: adding protease for enzymolysis;
s3: enzyme deactivation;
s4: performing membrane filtration, collecting filtrate, and vacuum concentrating;
s5: sterilizing, and spray drying to obtain the hydrolyzed small molecular protein powder.
7. The method according to claim 6, wherein the condition of the size mixing is pH 7.3-7.8; the temperature of the enzymolysis is 45-55 ℃; the temperature for enzyme deactivation is 110-120 ℃; the sterilization is instantaneous sterilization, and the temperature is 120-130 ℃; the inlet temperature of the spray drying is 170 ℃ and the outlet temperature is 80 ℃.
8. The method of claim 5, wherein the step of preparing the polysaccharide peptide of edible fungi comprises:
s1: adding the polysaccharide peptide raw material into production water, and dissolving; the polysaccharide peptide feedstock is selected from any one or a combination of: lucid ganoderma, cordyceps sinensis, shiitake mushroom, hericium erinaceus, agaricus blazei, flammulina velutipes and yeast powder;
s2: performing membrane filtration, collecting filtrate, and vacuum concentrating;
s3: spray drying to obtain the edible fungus polysaccharide peptide.
9. The method of claim 8, wherein the vacuum concentration conditions are: the concentration temperature is 60-85 ℃, and the vacuum degree is-0.06-0.08 Mpa; the inlet temperature of the spray drying is 180 ℃, and the outlet temperature is 90 ℃.
CN202010785095.8A 2020-08-06 2020-08-06 Nutritional formulation composition and method of making same Pending CN111838681A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024037484A1 (en) * 2022-08-15 2024-02-22 江苏蓝果临床营养科技有限公司 Nicotinamide mononucleotide composite and preparation method therefor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024037484A1 (en) * 2022-08-15 2024-02-22 江苏蓝果临床营养科技有限公司 Nicotinamide mononucleotide composite and preparation method therefor

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