CN111820903A

CN111820903A - Testing device for detecting plantar pressure of mouse during movement

Info

Publication number: CN111820903A
Application number: CN202010613343.0A
Authority: CN
Inventors: 刘展; 马赫迪; 王柏弋; 邵冰莓
Original assignee: Sichuan University
Current assignee: Sichuan University
Priority date: 2020-06-30
Filing date: 2020-06-30
Publication date: 2020-10-27

Abstract

The invention belongs to the technical field of animal experiments, and particularly relates to a test device capable of detecting plantar pressure of a mouse in the process of walking or running, which comprises the following components: the mouse comprises a replaceable rotating motor, a runway for mouse movement, a polyvinyl chloride running belt, a film pressure sensor, a transparent polyvinyl chloride protection plate, a replaceable gear frame, a polyvinyl chloride runway protection shell and a polyvinyl chloride base. Aiming at recording the plantar pressure of the mouse when the mouse walks or runs. The experiment device adopts the replaceable rotating motor, and can meet the experiment requirement of detecting the sole pressure of the white mouse at different walking speeds. The experimental device provides accurate and comprehensive experimental conditions for researching the plantar stress of the mouse during walking or running.

Description

Testing device for detecting plantar pressure of mouse during movement

Technical Field

The invention belongs to the technical field of animal experiments, and particularly relates to a test device capable of detecting plantar pressure of a mouse in the process of walking or running.

Background

The white mouse plays a difficult and unwearproof contribution in various experiments of human medical treatment, heredity, biological products and the like. As an experimental animal, a white mouse has the advantage of being unique. The experimental animals should have the following factors: easy feeding, high reproduction rate, high hereditary purity, metabolism type and physiological pathology close to those of human beings, and the like. In addition to the above conditions, the white mouse has the advantages of small individual difference, high test efficiency and low cost, and can breed a plurality of special varieties. With the technical progress, the white mouse is widely applied to various tests by virtue of the advantages of the white mouse, and the contribution of the white mouse to the field of gait analysis is very important.

The gait of the white mouse refers to the posture of the white mouse when walking or running. Animal gait analysis can be used to evaluate animal models of nerve trauma, nerve atrophy, nerve disease, and pain symptom groups. Gait analysis can provide reliable information for understanding the development process of related diseases, evaluating the effect of treatment methods and screening therapeutic drugs. Wherein, the foot pressure distribution in the gait cycle can be detected and recorded to reflect the result that the weight of the animal is distributed on the palms of the four feet during the walking or running process, and the parameter is very important for the whole gait analysis. Therefore, an experimental device special for detecting the sole pressure of the white mouse is necessary for accurately acquiring the foot pressure of the white mouse during walking under the condition of not influencing the movement of the white mouse.

Disclosure of Invention

The invention aims to provide an experimental device for detecting the plantar pressure of a white mouse in the walking or running process so as to comprehensively meet the requirement of detecting the plantar pressure of the white mouse in the current gait analysis process.

The embodiment of the invention provides an experimental device for detecting plantar pressure of a white mouse in a walking or running process, which comprises:

(1) in the detection device, a part for running a white mouse is designed into a closed circle (the projection of a coronal plane is a circle) similar to a mouse cage, the radius of the closed circle is 35 cm, and the width of a runway is 15 cm;

(2) the closed circular track is connected with a rotating motor through a gear so as to control the running speed and the moving distance of the white mouse through the rotating motor. Under the control of a rotating motor, the runway rotates 360 degrees around the circle center in one detection process at most, namely the maximum distance traveled by the mouse in a single test is about 219.8 centimeters;

(3) the running belt used by the device is made of polyvinyl chloride, and a high-precision film pressure sensor is arranged below the whole running belt so as to record the sole pressure of the white mouse during exercise in real time and output the cloud picture change of the sole pressure;

(4) the spaces on the two sides of the runway are sealed by transparent polyvinyl chloride protection plates, so that the mice cannot leave the runway in the experimental process, and the experiment personnel cannot be influenced to observe the movement of the mice;

the invention has the advantages that:

1. the runway is designed into a closed round shape similar to a squirrel cage, so that the floor area of the device is saved;

2. the walking or running speed of the white mouse can be controlled by using the rotating motor so as to provide richer experimental data;

3. the high-precision pressure sensor can be used for accurately acquiring the plantar pressure of the mice in the experimental process.

Description of the drawings:

fig. 1 is a front view of a plantar pressure detecting device;

fig. 2 is a sectional view of the plantar pressure detecting means;

in the figure: the device comprises a polyvinyl chloride protective shell 1, a gear frame 2, a transparent polyvinyl chloride protective plate 3, a polyvinyl chloride running belt 4, a film pressure sensor 5, a replaceable rotating motor 6, a polyvinyl chloride base 7 and a section schematic mark 8.

Detailed Description

The specific implementation case is as follows:

for ease of understanding, the invention will be explained in detail below with reference to an example and the accompanying drawings. Since the present invention can be properly developed and the description is not intended to fully enumerate all experimental solutions, other embodiments obtained by modifications based on the examples and without inventive step are within the scope of the present invention.

First, experimental preparation was conducted, which was designed to record the plantar pressure of healthy white mice when walking in nature and when they run at a speed of 3 m/s. The gear below the runway is used for controlling the start and the end of the experiment, the runway rotates 360 degrees in the process of one experiment, and the data of the film pressure sensor is recorded after the end of each experiment. Before the experiment, the runway part of the experimental device and the rotating motor are assembled, and healthy mice for the experiment are selected.

Further, the selected mice were placed on the runway and covered with the transparent protection plates of polyvinyl chloride on both sides of the runway.

First, the recording of the pressure on the soles of the white mouse during free running is performed to release the locked state of the rotating motor, 6 in fig. 1, so that the runway can be turned. And after the runway rotates by 360 degrees, locking the rotating motor to stop the runway, and finishing the experiment. Data of the thin film pressure sensor on the lower side of the runway, namely the plantar pressure of the mouse when running freely, were recorded.

Further, after ten minutes, the selected mice were placed on the runway and covered with the transparent protection plates of polyvinyl chloride on both sides of the runway to ensure that the mice had a full rest.

The recording of the pressure on the soles of the mice was carried out at a running speed of 3 m/s, and the motor speed was adjusted, as shown at 6 in fig. 1, so that the runway rotational linear speed was 3 m/s. And after the runway rotates by 360 degrees, locking the rotating motor to stop rotating the runway, and finishing the experiment. And recording data of the film pressure sensor at the lower side of the runway, namely the plantar pressure of the white mouse when the white mouse runs at a constant speed of 3 m/s, and finishing the experiment.

Claims

1. A testing arrangement that is used for plantar pressure to detect when mouse moves, its characterized in that includes: the track protection device comprises a polyvinyl chloride track protection shell (1), a replaceable gear frame (2), a transparent polyvinyl chloride protection plate (3), a polyvinyl chloride running belt (4), a film pressure sensor (5), a replaceable rotating motor (6) and a polyvinyl chloride base (7).

2. A testing arrangement for plantar pressure detects when mouse moves, its characterized in that: the rotation speed of the running belt is controlled by using the replaceable rotating motor (6) with adjustable rotating speed, the starting and the ending of the experiment are controlled by using the locking function of the replaceable rotating motor (6) with adjustable rotating speed, and the plantar pressure of the white mouse during the movement is recorded by using the film pressure sensor (5) under the running belt.

3. The replaceable rotating electrical machine (6) according to claim 1, characterized in that: the detachable installation mode is adopted, the installation is realized by a method with a uniform use form, and the replacement of the rotating motors with different rotating speeds can be realized.

4. A running belt (4) of pvc material as claimed in claim 1, characterised in that it is made of pvc and has anti-slip pattern on its surface to prevent the mice from slipping due to too fast running speed.

5. A running strip (4) of pvc according to claims 1 and 2, characterised in that the running strip (4) of pvc is connected to the interchangeable rotary motor (6) through the interchangeable gear frame (2) for runway speed control.

6. The gear for connecting a running track to a replaceable rotating electric machine according to claim 5, wherein the gear frame is replaceable.

7. In the experimental process, the runway can cause certain damage to the gear in the process of acceleration and braking, and the gear is replaced at regular time to ensure that the experiment is carried out smoothly.