CN111819436A - 用于使用质谱法量化两种或更多种分析物的方法和系统 - Google Patents

用于使用质谱法量化两种或更多种分析物的方法和系统 Download PDF

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Publication number
CN111819436A
CN111819436A CN201980017985.XA CN201980017985A CN111819436A CN 111819436 A CN111819436 A CN 111819436A CN 201980017985 A CN201980017985 A CN 201980017985A CN 111819436 A CN111819436 A CN 111819436A
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China
Prior art keywords
analyte
ions
intensity curve
ion cloud
cell
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Pending
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CN201980017985.XA
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English (en)
Chinese (zh)
Inventor
S.巴扎甘
H.巴蒂艾
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PerkinElmer Health Sciences Canada Inc
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PerkinElmer Health Sciences Canada Inc
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Publication of CN111819436A publication Critical patent/CN111819436A/zh
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0077—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction specific reactions other than fragmentation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0422—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for gaseous samples
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/105—Ion sources; Ion guns using high-frequency excitation, e.g. microwave excitation, Inductively Coupled Plasma [ICP]

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN201980017985.XA 2018-01-08 2019-01-07 用于使用质谱法量化两种或更多种分析物的方法和系统 Pending CN111819436A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862614888P 2018-01-08 2018-01-08
US62/614,888 2018-01-08
PCT/IB2019/050110 WO2019135205A1 (en) 2018-01-08 2019-01-07 Methods and systems for quantifying two or more analytes using mass spectrometry

Publications (1)

Publication Number Publication Date
CN111819436A true CN111819436A (zh) 2020-10-23

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US (2) US11133161B2 (cg-RX-API-DMAC7.html)
EP (1) EP3737936A4 (cg-RX-API-DMAC7.html)
JP (1) JP2021511487A (cg-RX-API-DMAC7.html)
KR (1) KR20200125594A (cg-RX-API-DMAC7.html)
CN (1) CN111819436A (cg-RX-API-DMAC7.html)
CA (1) CA3088913A1 (cg-RX-API-DMAC7.html)
WO (1) WO2019135205A1 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113237942A (zh) * 2021-05-07 2021-08-10 上海科技大学 在微量细胞中检测多种微量元素的方法及应用
US20240094097A1 (en) * 2022-09-15 2024-03-21 Analytik Jena Gmbh+Co. Kg System for analyzing a sample

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019135205A1 (en) * 2018-01-08 2019-07-11 Perkinelmer Health Sciences Canada, Inc Methods and systems for quantifying two or more analytes using mass spectrometry
US20250123603A1 (en) * 2023-10-16 2025-04-17 Thermo Finnigan Llc Method using reinforcement learning to control a mass spectrometer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5943062U (ja) * 1982-09-14 1984-03-21 株式会社東芝 粒子分析器
JP2895860B2 (ja) * 1989-05-26 1999-05-24 日本電信電話株式会社 質量分析方法
US6713757B2 (en) * 2001-03-02 2004-03-30 Mds Inc. Controlling the temporal response of mass spectrometers for mass spectrometry
US7479630B2 (en) * 2004-03-25 2009-01-20 Bandura Dmitry R Method and apparatus for flow cytometry linked with elemental analysis
WO2004029614A1 (en) * 2002-09-25 2004-04-08 Ionalytics Corporation Faims apparatus and method for separating ions
GB0404285D0 (en) * 2004-02-26 2004-03-31 Shimadzu Res Lab Europe Ltd A tandem ion-trap time-of flight mass spectrometer
JP4907196B2 (ja) * 2005-05-12 2012-03-28 株式会社日立ハイテクノロジーズ 質量分析用データ処理装置
DE102009050041B4 (de) * 2009-09-17 2014-12-18 Bruker Daltonik Gmbh Hochauflösende Ionenmobiltätsspektrometrie
JP5234019B2 (ja) * 2010-01-29 2013-07-10 株式会社島津製作所 質量分析装置
SG183179A1 (en) * 2010-02-26 2012-09-27 Perkinelmer Health Sci Inc Plasma mass spectrometry with ion suppression
GB201106689D0 (en) * 2011-04-20 2011-06-01 Micromass Ltd Function switching with fast asynchronous acquisition
AU2015218336B2 (en) * 2014-02-14 2019-08-15 Perkinelmer U.S. Llc Systems and methods for automated optimization of a multi-mode inductively coupled plasma mass spectrometer
EP3422005B1 (en) * 2017-06-27 2020-05-13 Medizinische Universität Graz Determining enrichments of tracers of glucose by mass spectrometry
WO2019135205A1 (en) * 2018-01-08 2019-07-11 Perkinelmer Health Sciences Canada, Inc Methods and systems for quantifying two or more analytes using mass spectrometry
JP7143737B2 (ja) * 2018-11-21 2022-09-29 株式会社島津製作所 質量分析装置、イオン発生タイミング制御方法およびイオン発生タイミング制御プログラム

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113237942A (zh) * 2021-05-07 2021-08-10 上海科技大学 在微量细胞中检测多种微量元素的方法及应用
CN113237942B (zh) * 2021-05-07 2023-09-26 上海科技大学 在微量细胞中检测多种微量元素的方法及应用
US20240094097A1 (en) * 2022-09-15 2024-03-21 Analytik Jena Gmbh+Co. Kg System for analyzing a sample

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Publication number Publication date
US11133161B2 (en) 2021-09-28
CA3088913A1 (en) 2019-07-11
JP2021511487A (ja) 2021-05-06
EP3737936A1 (en) 2020-11-18
US20210074533A1 (en) 2021-03-11
EP3737936A4 (en) 2021-10-13
KR20200125594A (ko) 2020-11-04
WO2019135205A1 (en) 2019-07-11
US20220262612A1 (en) 2022-08-18
US11637005B2 (en) 2023-04-25

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