CN1118141A - 结合使用可溶性补体受体-1(scr1)和脒基苯基或脒基萘基酯治疗炎症 - Google Patents

结合使用可溶性补体受体-1(scr1)和脒基苯基或脒基萘基酯治疗炎症 Download PDF

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Publication number
CN1118141A
CN1118141A CN94191260A CN94191260A CN1118141A CN 1118141 A CN1118141 A CN 1118141A CN 94191260 A CN94191260 A CN 94191260A CN 94191260 A CN94191260 A CN 94191260A CN 1118141 A CN1118141 A CN 1118141A
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CN
China
Prior art keywords
apan
brl55730
amidinophenyl
ester
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN94191260A
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English (en)
Chinese (zh)
Inventor
D·E·I·莫沙考斯卡
R·A·G·史密夫
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of CN1118141A publication Critical patent/CN1118141A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN94191260A 1993-01-22 1994-01-21 结合使用可溶性补体受体-1(scr1)和脒基苯基或脒基萘基酯治疗炎症 Pending CN1118141A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9301289.6 1993-01-22
GB939301289A GB9301289D0 (en) 1993-01-22 1993-01-22 Novel composition

Publications (1)

Publication Number Publication Date
CN1118141A true CN1118141A (zh) 1996-03-06

Family

ID=10729169

Family Applications (1)

Application Number Title Priority Date Filing Date
CN94191260A Pending CN1118141A (zh) 1993-01-22 1994-01-21 结合使用可溶性补体受体-1(scr1)和脒基苯基或脒基萘基酯治疗炎症

Country Status (10)

Country Link
EP (1) EP0680332A1 (https=)
JP (1) JPH08505867A (https=)
CN (1) CN1118141A (https=)
AU (1) AU5863694A (https=)
CA (1) CA2153797A1 (https=)
GB (1) GB9301289D0 (https=)
NZ (1) NZ259737A (https=)
TW (1) TW241203B (https=)
WO (1) WO1994016719A1 (https=)
ZA (1) ZA94398B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09504524A (ja) * 1993-10-21 1997-05-06 ジー．ディー．サール アンド カンパニー 酸化窒素シンターゼ阻害剤として有用なアミジノ誘導体
GB9604518D0 (en) * 1996-03-02 1996-05-01 Smithkline Beecham Plc Novel compounds
US8088386B2 (en) * 1998-03-20 2012-01-03 Genentech, Inc. Treatment of complement-associated disorders
JP4897690B2 (ja) * 2004-10-12 2012-03-14 ジェネンテック， インコーポレイテッド 補体関連障害の予防および処置のためのＣＲＩｇポリペプチド
GB201800620D0 (en) 2018-01-15 2018-02-28 Univ Manchester C3b Binding Polypeptide

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ191320A (en) * 1978-09-07 1982-09-14 Beecham Group Ltd In vivo fibrinolytic enzyme having active site blocked by hydrolytically removable group pharmaceutical compositions
GB2095239B (en) * 1981-02-27 1985-03-06 Torii & Co Ltd Novel amidine compounds
JPS57179147A (en) * 1981-04-28 1982-11-04 Torii Yakuhin Kk Amidine derivative
US5256642A (en) * 1988-04-01 1993-10-26 The Johns Hopkins University Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof
AU9149791A (en) * 1990-12-06 1992-07-08 T Cell Sciences, Inc. Synergistic compositions of soluble complement receptors and compounds that inhibit complement and/or suppress immune activity

Also Published As

Publication number Publication date
CA2153797A1 (en) 1994-08-04
WO1994016719A1 (en) 1994-08-04
NZ259737A (en) 1997-04-24
GB9301289D0 (en) 1993-03-17
ZA94398B (en) 1994-11-15
TW241203B (https=) 1995-02-21
JPH08505867A (ja) 1996-06-25
AU5863694A (en) 1994-08-15
EP0680332A1 (en) 1995-11-08

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WD01 Invention patent application deemed withdrawn after publication