CN111802524A - Antioxidant free radical detoxifying promoting additive for sows - Google Patents
Antioxidant free radical detoxifying promoting additive for sows Download PDFInfo
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- CN111802524A CN111802524A CN202010754476.XA CN202010754476A CN111802524A CN 111802524 A CN111802524 A CN 111802524A CN 202010754476 A CN202010754476 A CN 202010754476A CN 111802524 A CN111802524 A CN 111802524A
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- sows
- free radical
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- promoting additive
- peptidase
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- 150000003254 radicals Chemical class 0.000 title claims abstract description 42
- 239000003963 antioxidant agent Substances 0.000 title claims abstract description 28
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- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
- A23K10/18—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions of live microorganisms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/21—Streptococcus, lactococcus
- A23V2400/249—Thermophilus
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Birds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an antioxidant free radical detoxification-promoting additive for sows, which comprises the following components in parts by weight: 26-40% of peptidase, 8-13% of streptococcus thermophilus, 1-2% of glutathione, 1.5-2.5% of catalase, 0.5-1.5% of glucose oxidase, 1.5-3.5% of stachyose and 38-58% of carrier. The invention separates out peptidase by domesticating, culturing and fermenting a plurality of beneficial bacterium substrates, can accurately express on ovary, uterus, spiral artery epithelial cells, corpus luteum and granular cells, thereby effectively regulating the ovary function, relieving obstacles and maintaining normal hormone secretion in vivo, ensuring that sows can successfully estre in one period (18-25 days), controlling the corpus luteum ablation time of weaned sows within 2-3 days, and obviously improving the mammary gland development of the sows in 110 days of gestation and 7 days of lactation. The feed is added with 0.2 percent of the product to feed sows with oxidative stress for a period to comprehensively regulate and strengthen metabolism, and the comprehensive effective rate of solving the stress problem caused by oxidative free radicals of the sows is up to 97.2 percent.
Description
Technical Field
The invention relates to the field of sow breeding, in particular to an antioxidant free radical toxin-expelling promoting additive for sows.
Background
Solves the problem of oxidative stress of the sows caused by a large amount of free radicals generated in the sows at the later stage of pregnancy and the lactation period,
the high-yield sow has vigorous nutritional requirements in late gestation period (from 75 days to delivery), fetal growth (71 percent of body weight), mammary gland growth, lactation period and the like, and the feeding amount and nutrient intake in the lactation period after gestation are insufficient, so that the catabolism is vigorous, and a large amount of active oxygen free radicals are generated. When the level of free radicals produced in the somatic cells of sows is higher than the antioxidant defense capacity of the cells, the redox state is unbalanced. Excessive free radicals exist in tissues or cells, induce oxidative stress and cause oxidative damage, DNA oxidative damage is increased in the late gestation period and the lactation period, the phenomenon of intestinal injury is obvious, and the reproductive performance of sows is seriously influenced.
The existing corresponding technical scheme has the following problems and disadvantages:
1. the traditional Chinese medicine is antioxidant: when the sows have oxidative stress, the feed is added with the Chinese medicine residues of astragalus, angelica, motherwort, honeysuckle and the like, and the feed has poor absorption, low conversion rate, oxidation resistance ratio of 10-16% and low effective rate due to large addition amount, poor palatability, coarse Chinese medicine fibers, damaged intestinal tracts and the like of the sows.
2. Nutritional intervention: the sow is subjected to antioxidation by adjusting the nutrition scheme and the processing mode of the feed, and the exogenous antioxidant is mainly added into the daily ration, but is easy to be used excessively, so that the release of oxygen free radicals is increased, a somatostatin secretion system is damaged, and the activity of the antioxidant enzyme is reduced sharply; meanwhile, due to intestinal injury, the absorption rate of nutrient components is low, and the expected effect cannot be achieved. At present, the import price of products on the market is higher, the cultivation cost is increased, the recommended dosage is too low, and the expected effect cannot be achieved. At present, the quality of domestic products is not consistent, even the products need to be carefully screened when being selected by a large number of users, the safety of the products is also high, certain manufacturers even mix industrial antioxidants in the products, the products are low in price and the benefits of farmers are damaged.
3. The soybean isoflavone is proposed to be used for inhibiting and eliminating the oxidative free radicals of the sows in the industry at present, so that the soybean isoflavone has a good effect on inhibiting and eliminating the oxidative free radicals of the sows on the whole, but has certain safety risk. Genistein in soybean isoflavone belongs to low-toxicity substances, the toxicity of genistein mainly shows estrogen-like action, and can cause reproductive toxicity effects such as sexual precocity, pseudopregnancy, placenta absorption, dead fetus, abortion, sterility and the like of experimental animals, the weight and organ weight of the animals are reduced, and the animals can die in case of an overlarge dose. Administering genistein 500mg/kg to newborn or prepubertal rat can promote differentiation of mammary gland, uterus and ovary, and increase mammary gland weight. These pose potential safety risks, increase the individualized requirements on the dosage used and are difficult to control by the breeding users.
4. The use of the microbial antioxidant proposed in the industry can only improve the antioxidant capacity of the sows to a certain extent and enhance the reproductive performance of the sows, and does not achieve ideal effects.
Disclosure of Invention
The invention aims to overcome the defects of the traditional technology, provide the additive for promoting the detoxification of the sow antioxidant free radicals, and solve the problem that the oxidative stress of the sow cannot be efficiently solved due to the fact that the sow antioxidant free radicals depend on traditional Chinese medicine residues and nutritional intervention and the use of soybean isoflavone. The technical scheme of the invention mainly solves the problem of oxidative stress of the sows, removes active oxidative free radicals of the sows, promotes detoxification and improves reproductive performance of the sows.
The aim of the invention is achieved by the following technical measures:
the antioxidant free radical detoxifying promoting additive for sows is characterized in that: the formula comprises the following components in percentage by weight:
26-40% of peptidase, 8-13% of streptococcus thermophilus, 1-2% of glutathione, 1.5-2.5% of catalase, 0.5-1.5% of glucose oxidase, 1.5-3.5% of stachyose and 38-58% of carrier.
As a specific preferred scheme, the additive is composed of the following formula in parts by weight: peptidase 33.7%, streptococcus thermophilus 11%, glutathione 1.5%, catalase 2%, glucose oxidase 1%, stachyose 2.3%, and carrier 48.5%.
Preferably, the carrier is glucose.
The preparation process conditions of the additive are as follows: low temperature, antistatic, stepwise mixing.
Storage requirements for the above additives: ventilating, and storing in shade to avoid illumination and ultraviolet irradiation.
The application of the antioxidant free radical toxin expelling promoting additive for the sows is used for treating oxidative stress in the sows at the later gestation period and/or the lactation period.
The application method of the antioxidant free radical toxin expelling promoting additive for the sows is characterized in that the antioxidant free radical toxin expelling promoting additive for the sows is added into feed of the sows in the gestation period and/or the lactation period according to the weight ratio of 0.2%.
Based on the current market and the condition in the industry, the method mainly solves the problem of oxidative stress of the sows, removes active oxidative free radicals of the sows, promotes detoxification, and improves the reproductive performance of the sows. The separated peptidase is domesticated, cultured and fermented by a plurality of beneficial bacterium bottom materials, the ovary function is regulated, the disorder is relieved, the normal hormone secretion in vivo is maintained, the disorder of the breeding and metabolism of sows is relieved, the damage of the structure form of the alimentary canal mucosa of the sows is repaired, the secretion function of the alimentary canal is enhanced, the digestion absorption, transportation and assimilation metabolism functions are enhanced, and the feed utilization rate is improved. Has effects in relieving cell immunosuppression of sow body, and enhancing anti-infection ability of body.
The compatibility characteristics of the components of the application are described as follows.
1. The peptidase separated by domesticating, culturing and fermenting a plurality of beneficial bacterium substrates is added, so that the ovarian function can be effectively regulated, the disorder is relieved, and the normal hormone secretion in vivo is maintained. Through the metabolism activation of peptidase to protein and fat, the anabolism capability of liver is accelerated, the enhancement of lactation capability is promoted, and the reproduction and metabolic disorders of sows are relieved.
2. Streptococcus thermophilus, which is considered a "recognized safety" ingredient, is added, and also has some functional activities, such as the production of exopolysaccharides, bacteriocins and vitamins. In addition, the streptococcus thermophilus can also be used as a potential beneficial bacterium, and experiments prove that the streptococcus thermophilus has a health effect, a transport activity and a certain gastrointestinal tract adhesion property, and has the effects of improving the intestinal microenvironment, reducing the pH value of an intestinal tract, promoting intestinal peristalsis, preventing pathogenic bacteria from being planted and secreting bacteriocin to inhibit the growth of the pathogenic bacteria; regulating blood pressure, inhibiting cholesterol synthase activity, reducing cholesterol content in blood serum, and regulating and controlling blood pressure with its fermented product; superoxide dismutase (SOD) is produced to scavenge excess superoxide anion radicals produced during metabolism in vivo.
3. Three typical and safe components such as glutathione, catalase and glucose oxidase are added to enhance the anti-oxidation free radical capacity of the technology. Glutathione (GSH) is formed by combining glutamic acid, cysteine and glycine, tripeptide containing sulfhydryl groups can help to keep normal immune system functions, has the functions of antioxidation and integrated detoxification, and has the molecular characteristics of active sulfhydryl (-SH), which is the most important functional group, can participate in various important biochemical reactions of organisms, protects important enzyme protein sulfhydryl in vivo from oxidation and inactivation, and ensures energy metabolism and cell utilization. Meanwhile, the sulfhydryl is combined with free radicals in vivo, so that the free radicals can be directly reduced into acidic substances, the excretion of the free radicals is accelerated, and the damage of the free radicals to important organs is resisted. Catalase is mainly used to decompose hydrogen peroxide, a waste product generated in metabolic processes, and prevent hydrogen peroxide from damaging organisms. The glucose oxidase is added to mainly protect the integrity of intestinal epithelial cells, control coccidiosis outbreak, keep the ecological balance of intestinal flora, improve the immunity of the organism, relieve intestinal mycotoxin poisoning, relieve the over-standard harm of feed mould, eliminate the living environment of intestinal pathogenic bacteria, reduce salmonella infection and the like, and protect easily-oxidized components in the feed.
4. The stachyose is added with the value-added beneficial bacteria, targeted colonization is performed, the stachyose is a naturally-occurring tetrasaccharide, is extracted from natural plants, is safe and free of side effects, can be used for remarkably promoting the proliferation of beneficial bacteria such as bifidobacterium and the like, does not have any dependence, is targeted colonization, has an obvious effect, has good stability, can be directly colonized on each part of an intestinal tract, and is quick in effect and free of abdominal distension of sows.
The compound additive of the components has a synergistic effect, stachyose is beneficial to the proliferation of streptococcus thermophilus, the streptococcus thermophilus plays a role as a beneficial bacterium to a greater extent and has a health effect, a transport activity and a certain gastrointestinal tract adhesion, the intestinal microenvironment is improved, the intestinal pH value is reduced, the intestinal peristalsis is promoted, the colonization of pathogenic bacteria is prevented, bacteriocin is secreted to inhibit the growth of the pathogenic bacteria, and good positive feedback is provided for the stachyose targeting colonizing streptococcus thermophilus; regulating blood pressure, inhibiting cholesterol synthase activity, reducing cholesterol content in blood serum, and regulating and controlling blood pressure with its fermented product; superoxide dismutase (SOD) is produced to scavenge excess superoxide anion radicals produced during metabolism in vivo. Glutathione, catalase, glucose oxidase and the like enhance the antioxidant free radical capacity of the technology. Glutathione (GSH), is a tripeptide combined by glutamic acid, cysteine and glycine and containing sulfhydryl groups, can help to maintain the normal immune system function, has the functions of antioxidation, integration detoxification, effective regulation of ovarian function with peptidase, elimination of disorder, maintenance of normal hormone secretion in vivo, and jointly enhances the function of stachyose targeting and colonization of streptococcus thermophilus. The components have synergistic effect, and the components regulate immunity, improve ovarian function, relieve reproductive and metabolic disorders in sows, solve the problem of oxidative stress of sows, remove active oxidative free radicals of the sows, promote detoxification, and improve reproductive performance of the sows to be exerted to the best.
Due to the adoption of the technical scheme, compared with the prior art, the invention has the advantages that:
the invention discloses an antioxidant free radical toxin-expelling promoting additive for sows and application thereof. Thereby effectively regulating the ovarian function, relieving the disorder and maintaining the normal hormone secretion in vivo, and successfully oestrating in one cycle (18-25 days). Through the metabolism activation effect of peptidase on protein and fat, the anabolism capability of the liver is accelerated, the detoxification is promoted, and the mammary gland development of the sow in 110-day pregnancy and 7-day lactation is obviously improved. By adjusting the ovarian function, the ablation time of the corpus luteum of the weaned sow is controlled within 2-3 days. Beneficial bacteria are gained, harmful bacteria are inhibited, damage of the structure form of the digestive tract mucosa of the sow is repaired, the secretion function of the digestive tract is enhanced, the functions of digestive absorption, transportation and assimilation metabolism are enhanced, and the utilization rate of the feed is improved. Through characteristics and principle mechanisms of streptococcus thermophilus, glutathione and stachyose, the purposes of antagonizing and removing oxidative free radicals are achieved, and catalase protects an organism from being damaged by metabolites; particularly, the targeted colonization effect of stachyose is utilized to reach each part of intestinal tract, and the effects of resisting oxidation free radicals and promoting body detoxification of sows are efficiently achieved. Proved by experiments, the comprehensive effective rate of sows with oxidative stress is 97.2% by adding 0.2% of the feed into the feed to feed the sows for a period of regulation and comprehensively regulating and enhancing metabolism.
The present invention will be further described with reference to the following embodiments.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention discloses an antioxidant free radical detoxification-promoting additive for sows, which comprises the following components in parts by weight:
26-40% of peptidase, 8-13% of streptococcus thermophilus, 1-2% of glutathione, 1.5-2.5% of catalase, 0.5-1.5% of glucose oxidase, 1.5-3.5% of stachyose and 38-58% of carrier. The carrier is glucose
As a specific embodiment, the formulation of the weight ratio in the following examples is exemplified.
Examples 1 to 8:
the antioxidant free radical detoxifying promoting additive for sows in the embodiments is used for treating oxidative stress in sows at the later stage of pregnancy and/or lactation.
The formula proportion in example 8 is the preferred formula, and the concrete demonstration results of the demonstration experiments performed on the formula of the weight ratio in example 8 are as follows.
80 healthy and basically consistent 2-4 gestational white and large white binary pregnant sows in the expected delivery period are selected, and are divided into 4 groups by adopting single-factor completely random design, wherein each group has 20 sows and are fed in a single column. The control group is fed with basic diet, and the experiment 1 group is the diet added with 30g/t of glutathione, 40g/t of catalase and 20g/t of glucose oxidase in the basic diet; experiment 2 group is diet added with 674g/t of peptidase, 220g/t of streptococcus thermophilus and 46g/t of stachyose in basic diet; in the experiment 3 group, the peptidase 674g/t, the streptococcus thermophilus 220g/t, the glutathione 30g/t, the catalase 40g/t, the glucose oxidase 20g/t, the stachyose 46g/t and the glucose 970g/t are added into the basic diet, namely the sow antioxidant free radical toxin expelling promoting additive in the embodiment 8 is added into the feed of the experiment sow according to the weight ratio of 0.2%. The experimental period is the whole gestation period and the lactation period of the sow. The basic diet fed 90 days before pregnancy is pregnant sow diet, the basic diet fed from 90 days before pregnancy to delivery is lactating sow diet, and the composition and nutritional level of the basic diet are shown in table 1. Other daily management follows the normal management program of the pig farm.
Table 1: basal diet composition and nutritional level (air-dried basic material)
During the experiment period of the reproductive performance index of the sow, the total number of born sows and the number of live piglets are recorded, the litter weight of the sows during birth and weaning is weighed, and the number of dead piglets and the number of days between the return of the sows after weaning are recorded.
Table 2: influence of new technology on reproductive performance of pregnant sows
Note: the data in the same column are shoulder marked with different capital letters to indicate a significant difference P <0.05, and the data in the same row with different lower case letters to indicate a significant difference P <0.05 between different groups. The following table is the same.
As can be seen from Table 2, the number born alive, the birth weight and the weight of the litter in the experimental group tended to be significantly increased, wherein the number born alive and the weight of the litter in the experimental group 3 were respectively increased by 32.36% and 103.57% compared with the control group, respectively increased by 15.18% and 30.42% compared with the experimental group 1, and respectively increased by 22.56% and 40.60% compared with the experimental group 2; compared with a control group, the number of weaned heads of each experimental group is remarkably increased (P <0.05), and the weight of weaned litter also tends to be increased, wherein the weight of the weaned litter of the experimental group 3 is increased by 72.48% compared with that of the control group (P <0.05), the weight of a weaned individual is increased by 33.60%, the weight of the weaned litter of the experimental group 1 is increased by 31.98%, the weight of the individual is increased by 15.59%, the weight of the weaned litter of the experimental group 2 is increased by 41.51%, and the weight of the individual is increased by 18. The interval time from weaning to oestrus of the sows in the experimental group is obviously shortened, and is respectively shortened by 6.56d, 7.26d and 8.12d compared with that of the sows in the control group, the oestrus of each experimental group is relatively regular, and the oestrus synchronization degree of the sows in the experimental group is obviously improved. As can be seen from Table 2, the novel technology has obvious synergistic effect after adding peptidase, stachyose and streptococcus thermophilus, the reproductive performance of the sows is obviously improved, and the intestinal function is obviously improved.
Table 3: influence of new technology on SOD activity, GSH activity and MDA content in serum
SOD and CAD are the major endogenous antioxidant enzymes in body cells that scavenge free radicals. GSH scavenges free radicals, removes hydrogen and lipid peroxides, and prevents oxidation of biomolecules. In the experiment, experiments 1-3 show that after glutathione, catalase and glucose oxidase are added into daily ration and peptidase, streptococcus thermophilus and stachyose are added, an obvious synergistic effect is achieved, the activities of SOD and GSH in the serum of the sow on the 3 rd day after weaning are obviously enhanced, the content of MDA is gradually reduced, the reduction of free radicals in the sow body is proved, lipid peroxidation is weakened, the oxidative damage of the organism is relieved, and the further hydrolysis of peroxide is prevented to generate harmful substances MDA.
And (4) concluding the demonstration: the sow with oxidative stress is fed by adding 0.2% of the feed to adjust for one period, and the comprehensive effective rate reaches 97.2%.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (5)
1. The antioxidant free radical detoxifying promoting additive for sows is characterized in that: the formula comprises the following components in percentage by weight: 26-40% of peptidase, 8-13% of streptococcus thermophilus, 1-2% of glutathione, 1.5-2.5% of catalase, 0.5-1.5% of glucose oxidase, 1.5-3.5% of stachyose and 38-58% of carrier.
2. The antioxidant free radical detoxifying promoting additive for sows according to claim 1 wherein: the formula comprises the following components in percentage by weight: peptidase 33.7%, streptococcus thermophilus 11%, glutathione 1.5%, catalase 2%, glucose oxidase 1%, stachyose 2.3%, and carrier 48.5%.
3. The sow antioxidant free radical detoxification-promoting additive as claimed in claim 1 or 2, wherein: the carrier is glucose.
4. The use of the antioxidant free radical detoxifying promoting additive for sows according to claim 1, wherein: can be used for treating oxidative stress of sow in late gestation and/or lactation period.
5. The use method of the antioxidant free radical detoxifying promotion additive for sows according to claim 1, wherein: the antioxidant free radical detoxifying-promoting additive for sows, as claimed in claim 1, is added to the feed of sows in the gestation and/or lactation period in an amount of 0.2% by weight.
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Application publication date: 20201023 |