CN111801937B8 - 用于使用结构化照射检测颗粒的方法和系统 - Google Patents

用于使用结构化照射检测颗粒的方法和系统 Download PDF

Info

Publication number
CN111801937B8
CN111801937B8 CN201980010553.6A CN201980010553A CN111801937B8 CN 111801937 B8 CN111801937 B8 CN 111801937B8 CN 201980010553 A CN201980010553 A CN 201980010553A CN 111801937 B8 CN111801937 B8 CN 111801937B8
Authority
CN
China
Prior art keywords
structured illumination
particles
target
detecting particles
detection method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980010553.6A
Other languages
English (en)
Other versions
CN111801937A (zh
CN111801937B (zh
Inventor
柳济宽
李昊晋
吴雅琳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rebas Biosystems
Original Assignee
Rebas Biosystems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rebas Biosystems filed Critical Rebas Biosystems
Priority to CN202210890287.4A priority Critical patent/CN115373127A/zh
Publication of CN111801937A publication Critical patent/CN111801937A/zh
Application granted granted Critical
Publication of CN111801937B publication Critical patent/CN111801937B/zh
Publication of CN111801937B8 publication Critical patent/CN111801937B8/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/361—Optical details, e.g. image relay to the camera or image sensor
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G02B21/367—Control or image processing arrangements for digital or video microscopes providing an output produced by processing a plurality of individual source images, e.g. image tiling, montage, composite images, depth sectioning, image comparison
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0056—Optical details of the image generation based on optical coherence, e.g. phase-contrast arrangements, interference arrangements
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/008—Details of detection or image processing, including general computer control
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/06—Means for illuminating specimens
    • G02B21/08—Condensers
    • G02B21/14—Condensers affording illumination for phase-contrast observation
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/18—Arrangements with more than one light path, e.g. for comparing two specimens
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/36—Microscopes arranged for photographic purposes or projection purposes or digital imaging or video purposes including associated control and data processing arrangements
    • G02B21/365—Control or image processing arrangements for digital or video microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B27/00—Optical systems or apparatus not provided for by any of the groups G02B1/00 - G02B26/00, G02B30/00
    • G02B27/58—Optics for apodization or superresolution; Optical synthetic aperture systems
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03F—PHOTOMECHANICAL PRODUCTION OF TEXTURED OR PATTERNED SURFACES, e.g. FOR PRINTING, FOR PROCESSING OF SEMICONDUCTOR DEVICES; MATERIALS THEREFOR; ORIGINALS THEREFOR; APPARATUS SPECIALLY ADAPTED THEREFOR
    • G03F7/00—Photomechanical, e.g. photolithographic, production of textured or patterned surfaces, e.g. printing surfaces; Materials therefor, e.g. comprising photoresists; Apparatus specially adapted therefor
    • G03F7/70—Microphotolithographic exposure; Apparatus therefor
    • G03F7/70408—Interferometric lithography; Holographic lithography; Self-imaging lithography, e.g. utilizing the Talbot effect
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G06T7/0012—Biomedical image inspection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/10—Image acquisition
    • G06V10/12—Details of acquisition arrangements; Constructional details thereof
    • G06V10/14—Optical characteristics of the device performing the acquisition or on the illumination arrangements
    • G06V10/145—Illumination specially adapted for pattern recognition, e.g. using gratings
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00—Arrangements for image or video recognition or understanding
    • G06V10/40—Extraction of image or video features
    • G06V10/60—Extraction of image or video features relating to illumination properties, e.g. using a reflectance or lighting model
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00—Scenes; Scene-specific elements
    • G06V20/60—Type of objects
    • G06V20/69—Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/695—Preprocessing, e.g. image segmentation
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10056—Microscopic image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10141—Special mode during image acquisition
    • G06T2207/10152—Varying illumination
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30024—Cell structures in vitro; Tissue sections in vitro
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/30—Subject of image; Context of image processing
    • G06T2207/30004—Biomedical image processing
    • G06T2207/30072—Microarray; Biochip, DNA array; Well plate
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06V—IMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V2201/00—Indexing scheme relating to image or video recognition or understanding
    • G06V2201/04—Recognition of patterns in DNA microarrays

Landscapes

  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Multimedia (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

一种颗粒检测方法使用来自多个结构化照射图案的经测量的信号对目标上的颗粒的存在和位置进行检测。该颗粒检测方法使用通过利用结构化照射图案对目标进行照射而获得的经测量的信号来对颗粒进行检测。具体地，计算原始图像中这些测量信号的变化程度，以确定在目标上的特定的感兴趣区域处是否存在颗粒。
CN201980010553.6A 2018-01-30 2019-01-30 用于使用结构化照射检测颗粒的方法和系统 Active CN111801937B8 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210890287.4A CN115373127A (zh) 2018-01-30 2019-01-30 用于检测目标上的颗粒的方法和系统

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862624071P 2018-01-30 2018-01-30
US62/624,071 2018-01-30
PCT/US2019/015881 WO2019152539A1 (en) 2018-01-30 2019-01-30 Method for detecting particles using structured illumination

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN202210890287.4A Division CN115373127A (zh) 2018-01-30 2019-01-30 用于检测目标上的颗粒的方法和系统

Publications (3)

Publication Number Publication Date
CN111801937A CN111801937A (zh) 2020-10-20
CN111801937B CN111801937B (zh) 2022-08-12
CN111801937B8 true CN111801937B8 (zh) 2022-10-14

Family

ID=67393363

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201980010553.6A Active CN111801937B8 (zh) 2018-01-30 2019-01-30 用于使用结构化照射检测颗粒的方法和系统
CN202210890287.4A Pending CN115373127A (zh) 2018-01-30 2019-01-30 用于检测目标上的颗粒的方法和系统

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202210890287.4A Pending CN115373127A (zh) 2018-01-30 2019-01-30 用于检测目标上的颗粒的方法和系统

Country Status (4)

Country Link
US (2) US11366303B2 (zh)
EP (1) EP3747189A4 (zh)
CN (2) CN111801937B8 (zh)
WO (1) WO2019152539A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9857284B1 (en) * 2013-07-15 2018-01-02 Stratedigm, Inc. Method and apparatus for detection and measurement of particles with a wide dynamic range of measurement
WO2021065349A1 (ja) * 2019-10-02 2021-04-08 コニカミノルタ株式会社 ワークの表面欠陥検出装置及び検出方法、ワークの表面検査システム並びにプログラム
CN117689673B (zh) * 2024-02-04 2024-04-23 湘潭大学 基于分水岭的wc颗粒电镜图像分割及粒度分布计算方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103221806A (zh) * 2010-09-10 2013-07-24 奥林巴斯株式会社 使用两个以上的波长带的光的测量的光学分析方法
CN104764724A (zh) * 2006-12-12 2015-07-08 皇家飞利浦电子股份有限公司 用于检测标记颗粒的微电子传感器装置
WO2017060105A1 (en) * 2015-10-08 2017-04-13 Koninklijke Philips N.V. Particle sensor for particle detection
WO2017060164A1 (en) * 2015-10-08 2017-04-13 Koninklijke Philips N.V. Optical sensor for particle detection
CN106680159A (zh) * 2017-01-13 2017-05-17 浙江大学 基于动态光散射样本系综分析的颗粒快速检测方法及系统

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3785262A (en) 1969-12-09 1974-01-15 G Stroke Optical aperture synthesis
US3780217A (en) 1972-05-11 1973-12-18 Bendix Corp Heterodyne imaging device for providing high resolution images
US4890921A (en) 1986-08-11 1990-01-02 The Boeing Company Scanning interferometer
US5041733A (en) 1987-03-20 1991-08-20 Agency Of Industrial Science & Technology Method and apparatus for identifying chromosomes or cells
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
JPH03100628A (ja) 1989-09-14 1991-04-25 Sony Corp レーザ描画装置
US5751243A (en) 1990-10-29 1998-05-12 Essex Corporation Image synthesis using time sequential holography
US5341312A (en) 1991-09-26 1994-08-23 Eastman Kodak Company Method for assessing and correcting individual components of a non-monolithic imaging assembly
US5674698A (en) 1992-09-14 1997-10-07 Sri International Up-converting reporters for biological and other assays using laser excitation techniques
US5511060A (en) 1993-02-26 1996-04-23 Industrial Technology Research Institute Magneto-optical head with a three prism beam splitter to split a reflected beam into three beams
US5406412A (en) 1993-06-17 1995-04-11 Visidyne, Inc. High-resolution synthetic aperture adaptive optics system
US5470710A (en) 1993-10-22 1995-11-28 University Of Utah Automated hybridization/imaging device for fluorescent multiplex DNA sequencing
US6539805B2 (en) 1994-07-19 2003-04-01 Vesuvius Crucible Company Liquid metal flow condition detection
US6406848B1 (en) 1997-05-23 2002-06-18 Lynx Therapeutics, Inc. Planar arrays of microparticle-bound polynucleotides
US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US6654505B2 (en) 1994-10-13 2003-11-25 Lynx Therapeutics, Inc. System and apparatus for sequential processing of analytes
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US5750341A (en) 1995-04-17 1998-05-12 Lynx Therapeutics, Inc. DNA sequencing by parallel oligonucleotide extensions
US5780231A (en) 1995-11-17 1998-07-14 Lynx Therapeutics, Inc. DNA extension and analysis with rolling primers
US5763175A (en) 1995-11-17 1998-06-09 Lynx Therapeutics, Inc. Simultaneous sequencing of tagged polynucleotides
US6969488B2 (en) 1998-05-22 2005-11-29 Solexa, Inc. System and apparatus for sequential processing of analytes
US6016196A (en) 1997-06-17 2000-01-18 Massachusetts Institute Of Technology Multiple beam pair optical imaging
WO1999053355A1 (fr) 1998-04-15 1999-10-21 Vincent Lauer Microscope generant une representation tridimensionnelle d'un objet et images generees par ce microscope
KR20000004675A (ko) 1998-06-30 2000-01-25 전주범 복층 압전 광변위소자를 이용한 페이스 멀티플렉싱 타입 홀로그램 데이타 스토레지 시스템
US6787308B2 (en) 1998-07-30 2004-09-07 Solexa Ltd. Arrayed biomolecules and their use in sequencing
AR021833A1 (es) 1998-09-30 2002-08-07 Applied Research Systems Metodos de amplificacion y secuenciacion de acido nucleico
US6140660A (en) 1999-03-23 2000-10-31 Massachusetts Institute Of Technology Optical synthetic aperture array
JP2002542793A (ja) 1999-04-22 2002-12-17 ザ アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ 多蛍光ｆｉｓｈによる遺伝子発現パターンのアッセイ法
US6818395B1 (en) 1999-06-28 2004-11-16 California Institute Of Technology Methods and apparatus for analyzing polynucleotide sequences
US7211390B2 (en) 1999-09-16 2007-05-01 454 Life Sciences Corporation Method of sequencing a nucleic acid
WO2001023610A2 (en) 1999-09-29 2001-04-05 Solexa Ltd. Polynucleotide sequencing
WO2001061044A1 (en) 2000-02-15 2001-08-23 Lynx Therapeutics, Inc. Data analysis and display system for ligation-based dna sequencing
US6515287B2 (en) 2000-06-15 2003-02-04 Kla-Tencor Technologies Corporation Sectored magnetic lens and method of use
EP1311839B1 (en) 2000-06-21 2006-03-01 Bioarray Solutions Ltd Multianalyte molecular analysis using application-specific random particle arrays
WO2002037157A2 (fr) 2000-11-06 2002-05-10 Vincent Lauer Microscope pour objets diffractants
EP1432976A4 (en) 2001-09-05 2007-11-28 Genicon Sciences Corp DEVICE FOR READING SIGNALS EMITTED BY RESONANCE LIGHT DISPERSION PARTICLES USED AS MARKERS
AU2002353071A1 (en) 2001-12-06 2003-06-23 Florida Institute Of Technology Method and apparatus for spatial domain multiplexing in optical fiber communications
US6980677B2 (en) * 2002-05-24 2005-12-27 Niles Scientific, Inc. Method, system, and computer code for finding spots defined in biological microarrays
WO2004027491A1 (en) 2002-09-18 2004-04-01 Teraview Limited Apparatus for varying the path length of a beam of radiation
US7405114B2 (en) 2002-10-16 2008-07-29 Semiconductor Energy Laboratory Co., Ltd. Laser irradiation apparatus and method of manufacturing semiconductor device
US7122384B2 (en) 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
US8268551B2 (en) 2003-01-27 2012-09-18 San Diego State University Foundation Sensitive sensing based on optical nonlinear wave mixing
KR200327028Y1 (ko) 2003-06-17 2003-09-19 장시창 인체조직검사기구
WO2005043519A1 (en) 2003-10-30 2005-05-12 Koninklijke Philips Electronics N.V. Multi-beam optical scanning device
US7169560B2 (en) 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US7425703B2 (en) 2004-02-20 2008-09-16 Ebara Corporation Electron beam apparatus, a device manufacturing method using the same apparatus, a pattern evaluation method, a device manufacturing method using the same method, and a resist pattern or processed wafer evaluation method
JP2007526772A (ja) 2004-02-27 2007-09-20 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ インサイチュー配列決定用ポロニー蛍光ビーズ
TW200602814A (en) 2004-03-29 2006-01-16 Fuji Photo Film Co Ltd Exposure device
US20050221351A1 (en) 2004-04-06 2005-10-06 Affymetrix, Inc. Methods and devices for microarray image analysis
DE202004009856U1 (de) 2004-06-23 2004-09-30 Raylase Ag Vorrichtung zur Regelung der Leistung eines Laserstrahls
US20060024711A1 (en) 2004-07-02 2006-02-02 Helicos Biosciences Corporation Methods for nucleic acid amplification and sequence determination
US7276720B2 (en) 2004-07-19 2007-10-02 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20060012793A1 (en) 2004-07-19 2006-01-19 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
EP2194485B1 (en) 2004-11-16 2012-10-17 Illumina, Inc. Method and apparatus for reading coded microbeads
US20070070349A1 (en) 2005-09-23 2007-03-29 Helicos Biosciences Corporation Optical train and method for TIRF single molecule detection and analysis
US7307700B1 (en) 2004-12-17 2007-12-11 The Boeing Company Ultra-linear signal processing for radar and laser radar
US7397018B1 (en) 2005-03-02 2008-07-08 Lockheed Martin Corporation Amplitude and phase controlled adaptive optics system
DK2463386T3 (en) 2005-06-15 2017-07-31 Complete Genomics Inc Nucleic acid analysis using random mixtures of non-overlapping fragments
US7916144B2 (en) 2005-07-13 2011-03-29 Siemens Medical Solutions Usa, Inc. High speed image reconstruction for k-space trajectory data using graphic processing unit (GPU)
WO2007019422A2 (en) 2005-08-05 2007-02-15 Helicos Biosciences Corporation Signal pattern compositions and methods
US7967205B2 (en) 2005-11-17 2011-06-28 Hand Held Products, Inc. Optical reading device with programmable parameter control
US8053145B2 (en) 2006-05-30 2011-11-08 Semiconductor Energy Laboratory Co., Ltd. Method for manufacturing holographic recording medium and method for manufacturing semiconductor device
EP2078222B1 (en) 2006-07-10 2014-06-18 The Board Of Trustees Of The University Of Illinois Interferometric synthetic aperture microscopy
US8821799B2 (en) * 2007-01-26 2014-09-02 Palo Alto Research Center Incorporated Method and system implementing spatially modulated excitation or emission for particle characterization with enhanced sensitivity
KR100969946B1 (ko) 2007-07-24 2010-07-14 주식회사 이오테크닉스 레이저 빔 분할을 이용한 레이저 가공 장치 및 방법
US8222040B2 (en) * 2007-08-28 2012-07-17 Lightspeed Genomics, Inc. Nucleic acid sequencing by selective excitation of microparticles
US8759077B2 (en) * 2007-08-28 2014-06-24 Lightspeed Genomics, Inc. Apparatus for selective excitation of microparticles
EP2185992B1 (en) 2007-09-04 2013-07-17 Apple Inc. Smart dock for chaining accessories
US7916293B2 (en) * 2007-12-04 2011-03-29 Particle Measuring Systems, Inc. Non-orthogonal particle detection systems and methods
US8659845B2 (en) 2008-04-07 2014-02-25 University Of Florida Research Foundation, Inc. High-precision monolithic optical assemblies and methods for fabrication and alignment thereof
US8039776B2 (en) 2008-05-05 2011-10-18 California Institute Of Technology Quantitative differential interference contrast (DIC) microscopy and photography based on wavefront sensors
DE102008035770A1 (de) * 2008-07-31 2010-02-18 Eads Deutschland Gmbh Optischer Partikeldetektor sowie Detektionsverfahren
GB2463967B (en) 2008-08-26 2011-12-28 Univ Glasgow Uses of electromagnetic interference patterns
WO2010111656A2 (en) 2009-03-27 2010-09-30 Life Technologies Corporation Systems and methods for assessing images
US8705043B2 (en) 2009-12-14 2014-04-22 Academia Sinica Height measurement by correlating intensity with position of scanning object along optical axis of a structured illumination microscope
US8502867B2 (en) 2010-03-19 2013-08-06 Lightspeed Genomics, Inc. Synthetic aperture optics imaging method using minimum selective excitation patterns
US9465228B2 (en) * 2010-03-19 2016-10-11 Optical Biosystems, Inc. Illumination apparatus optimized for synthetic aperture optics imaging using minimum selective excitation patterns
US9605941B2 (en) * 2011-01-06 2017-03-28 The Regents Of The University Of California Lens-free tomographic imaging devices and methods
CN105008919B (zh) * 2013-03-06 2018-11-13 生物研究技术公司 分子成像和相关方法
EP3029505A4 (en) * 2013-07-31 2017-03-15 Olympus Corporation Optical microscope device, microscopy method, and computer program for microscopy using single-light-emitting-particle detection technology
CN105659143B (zh) * 2013-07-31 2019-03-22 加州理工学院 孔径扫描傅立叶重叠关联成像
US10012589B2 (en) * 2013-08-16 2018-07-03 The General Hospital Corporation Portable diffraction-based imaging and diagnostic systems and methods
FR3027107B1 (fr) * 2014-10-09 2019-09-13 Espci Paristech Methode et dispositif de detection optique de nanoparticules dans un echantillon fluide
CN110873957A (zh) * 2014-12-22 2020-03-10 加州理工学院 用于厚样本的epi照明傅立叶重叠关联成像
US10187626B2 (en) * 2015-04-10 2019-01-22 The Board Of Trustees Of The Leland Stanford Junior University Apparatuses and methods for three-dimensional imaging of an object
US10228550B2 (en) * 2015-05-21 2019-03-12 California Institute Of Technology Laser-based Fourier ptychographic imaging systems and methods
US20170168285A1 (en) * 2015-12-14 2017-06-15 The Regents Of The University Of California Systems and methods for image reconstruction
US10386300B2 (en) * 2015-12-21 2019-08-20 Verily Life Sciences Llc Spectrally and spatially multiplexed fluorescent probes for in situ cell labeling
CN109564617B (zh) * 2016-06-13 2023-09-26 纳诺利弗股份有限公司 表征和成像微观物体的方法
US20180246314A1 (en) * 2017-02-03 2018-08-30 Massachusetts Institute Of Technology Tunable microlenses and related methods
CN107065159B (zh) * 2017-03-24 2019-10-18 南京理工大学 一种基于大照明数值孔径的大视场高分辨率显微成像装置及迭代重构方法
WO2019090149A1 (en) * 2017-11-03 2019-05-09 California Institute Of Technology Parallel digital imaging acquisition and restoration methods and systems

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104764724A (zh) * 2006-12-12 2015-07-08 皇家飞利浦电子股份有限公司 用于检测标记颗粒的微电子传感器装置
CN103221806A (zh) * 2010-09-10 2013-07-24 奥林巴斯株式会社 使用两个以上的波长带的光的测量的光学分析方法
WO2017060105A1 (en) * 2015-10-08 2017-04-13 Koninklijke Philips N.V. Particle sensor for particle detection
WO2017060164A1 (en) * 2015-10-08 2017-04-13 Koninklijke Philips N.V. Optical sensor for particle detection
CN106680159A (zh) * 2017-01-13 2017-05-17 浙江大学 基于动态光散射样本系综分析的颗粒快速检测方法及系统

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Statistics of Particle Detection From Single-Channel Fluorescence Signals for Flow Cytometric Applications";Siegfried W. Kettlitz等;《 IEEE Transactions on Instrumentation and Measurement ( Volume: 62, Issue: 7, July 2013)》;20130329;全文 *
"生物颗粒流式成像关键技术的研究";朱险峰;《中国博士学位论文全文数据库》;20110715;全文 *

Also Published As

Publication number Publication date
US11841495B2 (en) 2023-12-12
WO2019152539A1 (en) 2019-08-08
EP3747189A4 (en) 2021-11-10
US20220334368A1 (en) 2022-10-20
CN111801937A (zh) 2020-10-20
CN115373127A (zh) 2022-11-22
US20190235222A1 (en) 2019-08-01
US11366303B2 (en) 2022-06-21
EP3747189A1 (en) 2020-12-09
CN111801937B (zh) 2022-08-12

Similar Documents

Publication Publication Date Title
CN111801937B8 (zh) 用于使用结构化照射检测颗粒的方法和系统
AU2014338756B2 (en) Method and device for tyre condition analysis
MX343978B (es) Dispositivo y metodo para la deteccion de señales de luz dispersada.
NZ596554A (en) Determining paint sample volume characteristics with a sensor to emit and detect signals reflected from the sample and create data sets relating to the sample and a reference sample
JP2011523065A5 (zh)
CA2561923A1 (en) Measuring apparatus and method in a distribution system
WO2017030652A8 (en) Sensing targets using photothermal speckle detection
EP2369318A3 (en) Thermal Measurement System and Method for Leak Detection
CN204177363U (zh) 一种镜面瓷砖平整度在线检测装置
EP2581713A3 (en) Encoder and apparatus using the same
US10801831B2 (en) Speckle measurement apparatus and speckle measurement method
MX2016010525A (es) Dispositivo, sistema y metodo de determinacion de signos vitales de un sujeto basado en luz reflejada y transmitida.
EP2385354A3 (en) Optical encoder having contamination and defect resistant signal processing
TW200951426A (en) Apparatus for detecting periodic defect and method therefor
SG178898A1 (en) Feature detection and measurement in retinal images
US9261585B2 (en) Radar apparatus using image change detector and method of operating the same
DK2306429T3 (da) Apparat og fremgangsmåde til klassificering af køretøjer
JP2006099614A5 (zh)
EP1906209A3 (en) Systems and methods for classifying a substance
CN104822923B (zh) 用于确定内燃机的汽缸压力‑曲轴位置‑配属关系的方法
EP1574300A3 (en) Measuring system
EP2711731A3 (en) Method for detecting an object using ultrasonic waves and detection device for an object using the same
WO2018063471A3 (en) Optical near-field metrology
SG11201902579QA (en) Method of detecting particles on panel
EP1868066A3 (en) Optimization of statistical movement measurement for optical mouse, with particular application to laser-illuminated surfaces

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information
CB02 Change of applicant information

Address after: California, USA

Applicant after: Rebas biosystems

Address before: California, USA

Applicant before: Optical Bio System Inc.

GR01 Patent grant
GR01 Patent grant
CI03 Correction of invention patent
CI03 Correction of invention patent

Correction item: Inventor

Correct: Liu Jikuan|Li Haojin|Wu Yalin

False: Liu Jikuan|Li Haochen|Wu Yalin

Number: 32-02

Volume: 38

Correction item: Inventor

Correct: Liu Jikuan|Li Haojin|Wu Yalin

False: Liu Jikuan|Li Haochen|Wu Yalin

Number: 32-02

Page: The title page

Volume: 38