CN111741975B - 抗血管生成素-2抗体及其用途 - Google Patents

抗血管生成素-2抗体及其用途 Download PDF

Info

Publication number
CN111741975B
CN111741975B CN201980014282.1A CN201980014282A CN111741975B CN 111741975 B CN111741975 B CN 111741975B CN 201980014282 A CN201980014282 A CN 201980014282A CN 111741975 B CN111741975 B CN 111741975B
Authority
CN
China
Prior art keywords
ser
thr
gly
val
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201980014282.1A
Other languages
English (en)
Chinese (zh)
Other versions
CN111741975A (zh
Inventor
高圭永
裴点一
金美贞
朴珍成
徐修珍
金载领
朴将烈
金泌汉
吴汪烈
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Korea Advanced Institute of Science and Technology KAIST
Institute for Basic Science
Original Assignee
Korea Advanced Institute of Science and Technology KAIST
Institute for Basic Science
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Advanced Institute of Science and Technology KAIST, Institute for Basic Science filed Critical Korea Advanced Institute of Science and Technology KAIST
Priority claimed from PCT/KR2019/001983 external-priority patent/WO2019164219A1/en
Publication of CN111741975A publication Critical patent/CN111741975A/zh
Application granted granted Critical
Publication of CN111741975B publication Critical patent/CN111741975B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201980014282.1A 2018-02-20 2019-02-19 抗血管生成素-2抗体及其用途 Active CN111741975B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862633038P 2018-02-20 2018-02-20
US62/633,038 2018-02-20
KR10-2019-0018769 2019-02-18
KR1020190018769A KR102497171B1 (ko) 2018-02-20 2019-02-18 항-안지오포이에틴-2(Ang2) 항체 및 그의 용도
PCT/KR2019/001983 WO2019164219A1 (en) 2018-02-20 2019-02-19 Anti-angiopoietin-2 antibodies and uses thereof

Publications (2)

Publication Number Publication Date
CN111741975A CN111741975A (zh) 2020-10-02
CN111741975B true CN111741975B (zh) 2025-02-18

Family

ID=67775161

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980014282.1A Active CN111741975B (zh) 2018-02-20 2019-02-19 抗血管生成素-2抗体及其用途

Country Status (8)

Country Link
US (2) US11498962B2 (enExample)
EP (1) EP3755714A4 (enExample)
JP (2) JP7366068B2 (enExample)
KR (1) KR102497171B1 (enExample)
CN (1) CN111741975B (enExample)
AU (1) AU2019224694B2 (enExample)
CA (1) CA3091613A1 (enExample)
MX (1) MX2020008663A (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102497171B1 (ko) 2018-02-20 2023-02-08 기초과학연구원 항-안지오포이에틴-2(Ang2) 항체 및 그의 용도
WO2022005171A1 (ko) * 2020-06-30 2022-01-06 삼성전자 주식회사 항-ang2 항체를 포함하는 코로나바이러스 감염증을 치료하기 위한 조성물 및 그의 용도
US20230312698A1 (en) * 2020-08-07 2023-10-05 Nanjing GenScript Biotech Co., Ltd. Antibodies against human angiopoietin-2 and uses thereof
JP7669062B2 (ja) * 2020-08-19 2025-04-28 ファームアブシン・インコーポレイテッド 変形抗体及びその製造方法
KR102459211B1 (ko) * 2021-04-23 2022-10-26 (주)니오테스바이오 안지오포이에틴-2에 특이적으로 결합하는 항체, 또는 이의 단편
EP4328242A4 (en) * 2021-04-23 2025-07-16 Neortesbio Inc ANTIBODY SPECIFICALLY BINDING TO ANGIOPOIETIN-2 OR FRAGMENT THEREOF
WO2025178471A1 (ko) * 2024-02-20 2025-08-28 주식회사 맵틱스 Tie2 및 vegf에 특이적으로 결합하는 이중 특이적 항체 및 이의 용도
WO2025186364A1 (en) 2024-03-06 2025-09-12 Jeansson Marie Angpt2-targeting antibodies for use in the treatment of fibrotic diseases, particularly kidney disease(s), disorder(s) or injury associated with kidney fibrosis
CN121231772B (zh) * 2025-12-02 2026-03-17 武汉市金银潭医院(武汉市传染病医院) 抗体夹心法检测猴痘病毒a29l蛋白的试剂或试剂盒及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101602806A (zh) * 2003-11-26 2009-12-16 埃博马可西斯公司 针对血管内皮生长因子的人源化抗体
CN102257008A (zh) * 2008-12-16 2011-11-23 霍夫曼-拉罗奇有限公司 针对人血管生成素2的抗体

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7658924B2 (en) 2001-10-11 2010-02-09 Amgen Inc. Angiopoietin-2 specific binding agents
ZA200705695B (en) 2004-12-21 2009-02-25 Astrazeneca Ab Antibodies directed to angiopoietin-2 and uses thereof
US8980268B2 (en) * 2009-07-29 2015-03-17 Regeneron Pharamceuticals, Inc. Methods for treating cancer by administering an anti-Ang-2 antibody
JO3182B1 (ar) * 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
MX359833B (es) 2011-08-19 2018-10-12 Regeneron Pharma Anticuerpos anti-tie2 y usos de los mismos.
US9828422B2 (en) * 2013-07-29 2017-11-28 Samsung Electronics Co., Ltd. Anti-Ang2 antibody
KR102146845B1 (ko) 2013-07-30 2020-08-21 삼성전자주식회사 앤지오포이에틴-2에 특이적으로 결합하는 항체 및 그의 용도
KR102196450B1 (ko) 2013-09-17 2020-12-30 삼성전자주식회사 Tie2와 결합을 유도하는 항 Ang2 항체를 포함하는 항암제
KR102349370B1 (ko) 2014-05-26 2022-01-10 삼성전자주식회사 인간화 또는 친화도 성숙된 항 앤지오포이에틴-2 항체 및 그의 용도
JP2017534644A (ja) 2014-11-10 2017-11-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗ａｎｇ２抗体及び使用方法
KR102497171B1 (ko) 2018-02-20 2023-02-08 기초과학연구원 항-안지오포이에틴-2(Ang2) 항체 및 그의 용도

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101602806A (zh) * 2003-11-26 2009-12-16 埃博马可西斯公司 针对血管内皮生长因子的人源化抗体
CN102257008A (zh) * 2008-12-16 2011-11-23 霍夫曼-拉罗奇有限公司 针对人血管生成素2的抗体

Also Published As

Publication number Publication date
EP3755714A4 (en) 2022-02-16
JP2024009914A (ja) 2024-01-23
US20210079083A1 (en) 2021-03-18
AU2019224694B2 (en) 2025-09-04
JP2021514670A (ja) 2021-06-17
CN111741975A (zh) 2020-10-02
EP3755714A1 (en) 2020-12-30
US11498962B2 (en) 2022-11-15
US12331106B2 (en) 2025-06-17
US20230272057A1 (en) 2023-08-31
MX2020008663A (es) 2021-02-09
JP7366068B2 (ja) 2023-10-20
CA3091613A1 (en) 2019-08-29
AU2019224694A1 (en) 2020-08-06
KR20190100060A (ko) 2019-08-28
KR102497171B1 (ko) 2023-02-08

Similar Documents

Publication Publication Date Title
CN111741975B (zh) 抗血管生成素-2抗体及其用途
TWI809426B (zh) 抗Ｃｌａｕｄｉｎ１８.２抗體以及其用途
JP6513728B2 (ja) Ｈｅｒ３に特異的な結合分子及びそれらの使用
Hashimoto et al. Claudin-5-binders enhance permeation of solutes across the blood-brain barrier in a mammalian model
WO2018127519A1 (en) Antibodies specific for hyperphosphorylated tau for the treatment of ocular diseases
US12024562B2 (en) Antibody binding to Tie2 and use thereof
CN113150147A (zh) 抗-met抗体及其使用方法
WO2022068809A1 (zh) 抗cd3抗体以及其用途
WO2015076425A1 (ja) 新規モノクローナル抗体
AU2019409132A1 (en) Antibodies to PMEL17 and conjugates thereof
IL323270A (en) Antibody against PTK7 and its uses
CN112601760A (zh) 与c-met特异性结合的抗体及其用途
CN120958025A (zh) 针对含cub结构域的蛋白1(cdcp1)的抗体及其用途
KR20240056422A (ko) 인간 안지오포이에틴-2에 특이적으로 결합하는 제1 항원 결합 부위를 포함하는 이중특이적 항체 및 그 응용
TW202340246A (zh) D3結合分子及其用途
HK40115552A (zh) 抗ptk7抗体及其用途
HK40083793A (en) Anti-claudin18.2 antibody and use thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
TG01 Patent term adjustment

Free format text: NEW EXPIRY DATE: 20390821

TG01 Patent term adjustment