CN111721949B

CN111721949B - Sample analyzer, sample detection method, and computer-readable storage medium

Info

Publication number: CN111721949B
Application number: CN201910223450.XA
Authority: CN
Inventors: 胡力坚
Original assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Current assignee: Shenzhen Mindray Bio Medical Electronics Co Ltd
Priority date: 2019-03-22
Filing date: 2019-03-22
Publication date: 2024-03-29
Anticipated expiration: 2039-03-22
Also published as: CN111721949A

Abstract

The present application relates to a sample analyzer, comprising: a sample transport means arranged to transport a sample rack loaded with sample containers in a first direction or in a second direction opposite to the first direction; the first mixing device is used for carrying out mixing operation on the first type of sample containers; the second mixing device is used for carrying out mixing operation on the second type of sample containers; the sampling device is used for sampling the sample in the sample container; the detection device is used for detecting the sucked sample; the control device is used for controlling the sample conveying device to convey the sample container loaded with the sample to be tested to the sampling position along the first direction for sampling; when the sample to be detected is judged to need rechecking, the sample transporting device is controlled to transport the sample container needing rechecking to the sampling position again along the second direction for sampling. The application also relates to a corresponding sample detection method, a control device and a computer readable storage medium.

Description

Sample analyzer, sample detection method, and computer-readable storage medium

Technical Field

The present disclosure relates to the field of sample analysis, and more particularly, to a sample analyzer for detecting a trace sample and a corresponding sample detection method.

Background

In clinical diagnostic procedures, it is often necessary to use a sample analyzer to determine samples of blood, urine, body fluids (ascites, cerebral spinal cord, hydrothorax, etc.) taken from a patient. Typically, the sample analyzer will provide a predetermined desired sample size. Taking a blood sample as an example, there are two current blood sampling methods: venous blood collection and peripheral blood collection. The intravenous sampling mode has a large blood sampling amount (more than or equal to 1 mL), and is generally suitable for adult patients; in the case of infants, children or serious patients, blood collection by intravenous means is sometimes difficult, and in this case, peripheral blood is often collected, and the amount of blood that can be collected is relatively small (most cases are less than or equal to 100. Mu.L).

At present, when a doctor detects a blood routine project of a peripheral blood sample, the doctor is usually required to manually sample, and when the doctor encounters a sample with a questionable result, the doctor is required to manually pick out the sample for retesting, so that the doctor is very troublesome.

Based on the above problems and the urgent demands of the market for full-automatic measurement of peripheral blood, the application provides a sample analyzer and an analysis method, which have the function of automatic rechecking of peripheral blood samples.

Disclosure of Invention

According to a first aspect of the present application there is provided a sample analyser comprising: a sample transport means arranged to transport a sample rack loaded with sample containers in a first direction or in a second direction opposite to the first direction; the first mixing device is used for carrying out mixing operation on a first type of sample container filled with a trace amount of blood sample; the second mixing device is used for carrying out mixing operation on a second type of sample container filled with a constant blood sample; sampling means arranged to sample a sample in a sample container; a detection device configured to detect the sucked sample; and the control device is in communication connection with the sample conveying device, the first mixing device, the second mixing device, the sampling device and the detection device.

Wherein the control device is configured to: controlling the sample conveying device to convey the sample container loaded with the sample to be tested to a first mixing position or a second mixing position along the first direction for mixing; controlling the sample conveying device to convey a sample container loaded with a sample to be tested to a sampling position along the first direction for sampling; judging whether the sample to be detected needs rechecking; when the sample to be detected is judged to need rechecking, the sample transporting device is controlled to transport the sample rack along the second direction, so that the sample container needing rechecking is transported to the sampling position again for sampling.

Advantageously, the control device may be configured to determine, when it is determined that the sample to be tested needs to be re-inspected, whether the sample container to be re-inspected needs to be re-mixed before re-sampling, according to a waiting time determined by waiting for the re-inspection of the sample container to be re-inspected at the waiting position.

Further advantageously, the control means may be arranged for: when the sample container needing rechecking is judged to be uniformly mixed again, judging whether the sample container needing rechecking is a first type sample container or a second type sample container; when the sample container needing to be reexamined is judged to be a first type sample container, controlling the sample transporting device to transport the sample container needing to be reexamined to the first blending position along the second direction and controlling the first blending device to blend the sample container needing to be reexamined; when the sample container needing to be reexamined is a second type of sample container, controlling the sample transporting device to transport the sample container needing to be reexamined to the second blending position along the second direction and controlling the second blending device to blend the sample container needing to be reexamined; after the mixing operation of the sample container needing to be reexamined is completed, the sample transporting device is controlled to transport the sample rack along the first direction, so that the sample container needing to be reexamined is transported to the sampling position again for sampling.

According to a second aspect of the present application, there is provided a sample analyzer comprising: a sample transport means arranged to transport a sample rack loaded with sample containers in a first direction or in a second direction opposite to the first direction; the first mixing device is used for carrying out mixing operation on a first type of sample container filled with a trace amount of blood sample; the second mixing device is used for carrying out mixing operation on a second type of sample container filled with a constant blood sample; sampling means arranged to sample a sample in a sample container; a detection device configured to detect the sucked sample; and the control device is in communication connection with the sample conveying device, the first mixing device, the second mixing device, the sampling device and the detection device.

Wherein the control device is configured to: controlling the sample conveying device to convey the sample container loaded with the sample to be tested to a first mixing position or a second mixing position along the first direction for mixing; controlling the sample conveying device to convey a sample container loaded with a sample to be tested to a sampling position along the first direction for sampling; judging whether the sample to be detected needs rechecking; when judging that the sample to be detected needs to be rechecked, judging whether the sample container needing rechecked is a first type sample container or a second type sample container; when the sample container needing to be reexamined is judged to be a first type sample container, controlling the sample transporting device to transport the sample container needing to be reexamined to the first blending position along the second direction and controlling the first blending device to blend the sample container needing to be reexamined; when the sample container needing to be reexamined is a second type of sample container, controlling the sample transporting device to transport the sample container needing to be reexamined to the second blending position along the second direction and controlling the second blending device to blend the sample container needing to be reexamined; after the mixing operation of the sample container needing to be reexamined is completed, the sample transporting device is controlled to transport the sample rack along the first direction, so that the sample container needing to be reexamined is transported to the sampling position again for sampling.

A third aspect of the present application also provides a sample detection method, comprising the steps of: conveying the sample container loaded with the sample to be tested to a first mixing position or a second mixing position along the first direction for mixing; transporting the sample container loaded with the sample to be tested to a sampling position along the first direction for sampling; judging whether the sample to be detected needs rechecking; when judging that the sample to be detected needs to be rechecked, judging whether the sample container needing rechecked is a first type sample container or a second type sample container; when the sample container needing to be rechecked is judged to be a first type sample container, conveying the sample container needing to be rechecked to the first mixing position along the second direction for mixing operation; when the sample container needing to be rechecked is judged to be a second type sample container, conveying the sample container needing to be rechecked to the second mixing position along the second direction for mixing operation; after the mixing operation of the sample container needing to be re-inspected is completed, the sample rack is conveyed along the first direction, so that the sample container needing to be re-inspected is conveyed to the sampling position again for sampling.

Advantageously, the first blending location and the second blending location may be the same location or different locations.

A fourth aspect of the present application also provides a control device for a sample analyzer, comprising: at least one processor; and a memory storing instructions executable by the at least one processor, which when executed by the at least one processor, cause the sample analyzer to perform the sample detection method described above.

A fifth aspect of the present application also provides a computer-readable storage medium storing computer-executable instructions that, when executed by at least one processor of a sample analyzer, cause the sample analyzer to perform the above-described sample detection method.

The device and the method disclosed based on the technical scheme can effectively realize the functions of automatic detection and automatic rechecking of the peripheral blood sample.

Drawings

FIG. 1 is an oblique view of the appearance of a sample analyzer according to an embodiment of the present application in a first configuration;

FIG. 2 is an oblique view of the appearance of a sample analyzer according to an embodiment of the present application in a second state;

FIG. 3 is a schematic view of a sample rack for loading sample containers according to an embodiment of the present application;

FIG. 4 is a schematic view of a sample rack loaded with sample containers for micro-blood samples according to one embodiment of the present application;

FIG. 5 is a schematic view of a sample rack loaded with sample containers for constant blood samples according to one embodiment of the present application;

FIG. 6 is a perspective cutaway view of a sample container for a micro blood sample and a sample container for a macro blood sample according to one embodiment of the present application;

FIG. 7 is a partial perspective view of a sample analyzer according to an embodiment of the present application with a housing removed;

FIG. 8 is another partial perspective view of a sample analyzer according to an embodiment of the present application with a housing removed;

FIG. 9 is an oblique view of a sample transport device according to one embodiment of the present application;

FIG. 10 is a schematic diagram of a functional bit arrangement of a sample analyzer according to an embodiment of the present application;

FIG. 11 is a schematic diagram of another functional bit arrangement of a sample analyzer of an embodiment of the present application;

FIG. 12 is a first schematic flow chart diagram of a sample detection method according to an embodiment of the present application;

FIG. 13 is a second schematic flow chart diagram of a sample detection method according to an embodiment of the present application;

FIG. 14 is a third schematic flow chart diagram of a sample detection method according to an embodiment of the present application;

FIG. 15 is a fourth schematic flow chart diagram of a sample detection method according to an embodiment of the present application;

FIG. 16 is a fifth schematic flow chart diagram of a sample detection method according to an embodiment of the present application;

FIG. 17 is an oblique view of a first blending assembly according to an embodiment of the present application;

FIG. 18 is an oblique view of a sample container holder of a first mixing device according to an embodiment of the present disclosure;

fig. 19 is a schematic diagram of a sensor output signal of the first mixing device according to an embodiment of the present application;

fig. 20 is a cross-sectional view of a sample container holder of a first mixing device according to an embodiment of the present disclosure;

FIG. 21 is a cross-sectional view of the sample container holder of FIG. 20 at rest with a sample container received within its sample container receiving cavity, wherein a sample is received in the sample container;

FIG. 22 is a force analysis schematic diagram of a sample in a sample container when a sample container holder of a first mixing device according to an embodiment of the present disclosure is rotated;

fig. 23 is an oblique view of a second blending assembly according to an embodiment of the present application;

FIG. 24 is a schematic flow chart for blending a constant volume of blood in accordance with one embodiment of the present application;

FIG. 25 is a schematic flow chart for mixing trace amounts of blood according to an embodiment of the present application;

fig. 26 is a schematic structural view of a control device for a sample analyzer according to an embodiment of the present application.

Detailed Description

Embodiments of the present application are described in detail below, examples of which are illustrated in the accompanying drawings, wherein the same or similar reference numerals refer to the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by referring to the drawings are exemplary only for the purpose of illustrating the present application and are not to be construed as limiting the present application.

As used herein, the singular forms "a", "an", "the" and "the" are intended to include the plural forms as well, unless expressly stated otherwise, as understood by those skilled in the art. It will be further understood that the terms "comprises" and/or "comprising," when used in this specification, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. It will be understood that when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. Further, "connected" as used herein may include wireless connections. The term "and/or" as used herein includes all or any element and all combination of one or more of the associated listed items.

It will be understood by those skilled in the art that all terms (including technical and scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs unless defined otherwise. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the prior art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

The present application first provides a sample analyzer 1 having an automatic re-examination function of a peripheral blood sample, the sample analyzer 1 comprising: a sample transport means 3 arranged to transport a sample rack 80 loaded with sample containers 90 or 91 in a first direction X1 or in a second direction X2 opposite to the first direction; a first mixing device 21 configured to perform a mixing operation on a first type of sample container 90 containing a trace amount of blood sample; a second mixing device 22 arranged to perform a mixing operation on a second type of sample container 91 containing a constant volume of blood sample; sampling means 23 arranged to sample a sample in a sample container transported by said sample transport means 3 to a sampling location 203; detection means (not shown) arranged to detect the aspirated sample; control means (not shown) arranged to: controlling the sample transporting device 3 to transport the sample rack 80 along the first direction X1, so that the sample container 90 or 91 on the sample rack 80 is transported to the sampling position 203 for sampling; when it is determined that the sample in the sample container that has been sampled and transported to the waiting position 204 by the sample transporting device 3 needs to be reexamined, the sample transporting device 3 is controlled to transport the sample frame 80 along the second direction, so that the sample container that needs to be reexamined is transported to the sampling position 203 again, or the sample transporting device 3 is controlled to transport the sample frame 80 to the blending position 202 along the second direction for blending operation, and then the sample transporting device 3 is controlled to transport the sample frame 80 to the sampling position 203 along the first direction for sampling.

Fig. 1 and 2 are respectively oblique views of the appearance of a sample analyzer 1 according to an embodiment of the present application in two different modes, and the sample analyzer 1 includes a measuring device 2 and a sample transporting device 3 disposed on one side of the measuring device 2 in the Y1 direction. The sample transporting device 3 comprises two forms, wherein one form comprises an open sample injecting mechanism provided with an open sample injecting space and an open sample injecting key 4, and the open sample injecting mechanism can be used for carrying out single sample open sample injection, and comprises an automatic sample injecting mechanism which can be used for carrying out multi-sample batch automatic sample injection, as shown in figure 1; another form includes a sample cartridge assembly 5 that allows for single sample closed sampling and an autosampling mechanism that allows for multiple sample batch autosampling, as shown in fig. 2.

Fig. 3 is a schematic view of a sample rack 80 for loading sample containers according to an embodiment of the present application. As a component used in cooperation with the sample transporting device 3 of the sample analyzer 1, the sample rack 80 for fixing and loading the sample containers (i.e., blood collection tubes) may be provided with fixing holes 801 for fixing the sample containers, each fixing hole 801 may be correspondingly provided with an opening 802, and the opening 802 may be used as a code scanning window for encoding the sample containers. In addition, the sample holder 80 may be provided with a sample holder code label attaching area 803 exclusively, and the sample holder code label attaching area 803 may attach a barcode label, a two-dimensional code label, an RFID label, or the like.

The sample holder 80 may be used to hold a peripheral blood (i.e., trace blood sample) sample container 90, as shown in fig. 4, and may also be used to hold a venous blood (i.e., constant blood sample) sample container 91, as shown in fig. 5. As shown in fig. 6, the difference between the peripheral blood sample container 90 and the venous blood sample container 91 is: the tip blood sample container 90 has a smaller lumen, the lumen bottom 901 is not located at the lowest part of the sample container, and can hold a smaller sample volume; the lumen of the venous blood sample container 91 is larger and the lumen bottom 911 is located at the lowest portion of the sample container, which can accommodate a larger sample volume. Typically, the peripheral blood sample container 90 will collect a relatively small sample size, typically less than or equal to 150uL; the venous blood sample container 91 has a small sample size, and is generally 1mL or more.

As shown in fig. 7, which shows a partial oblique view of the sample analyzer 1 after removal of the housing. The measuring device 2 may comprise a first mixing device 21, a handling device 22, a sampling device 23 and reaction and detection devices not shown in the figures. The first mixing device 21 is provided for mixing the peripheral blood sample in the peripheral blood sample container 90, and the handling device 22 is provided for handling the peripheral blood sample container 90 between the sample rack 80 and the first mixing device 21. Meanwhile, the carrying device 22 may be a second mixing device provided for mixing the venous blood sample in the venous blood sample container 91. The sampling device 23 is arranged for pipetting samples from a sample container fixed to the sample holder 80. The reaction device is provided for providing a place where the sample sucked by the sampling device 23 reacts with the corresponding reagent to prepare a sample to be measured.

As shown in fig. 8, another partial oblique view of the sample analyzer 1 is shown after removal of the housing. The measuring device 2 may further comprise, among other things, a test tube compacting device 24, a test tube rotating device 25 and a code scanner 26. The tube pressing device 24 and the tube rotating device 25 cooperate to rotate the sample container fixed to the sample holder 80, with the side of the sample container to which the coded information is attached turned toward the code scanner 26. The code scanner 26 is arranged to read the coded information on the sample container and/or to read the coded information of the sample holder 80.

As shown in fig. 9, fig. 9 is an oblique view of the sample transport device 3 according to an embodiment of the present application. The sample transport apparatus 3 includes a sample rack supporting member 31, a sample rack feeding device 32, a sample rack bidirectional conveying device 33, and a sample rack discharging device 34. Wherein the sample rack supporting member 31 includes: a sample rack storage area to be measured 3101 in which a number of sample racks 80 to which sample containers to be measured are fixed can be placed, a sample rack storage area to be measured 3102 in which a number of sample racks 80 to which sample containers to be measured are fixed can be placed, and a sample analysis area 3103 located between the sample rack storage area to be measured 3101 and the sample rack storage area to be measured 3102 and preferably close to the measuring device 2. A sample rack feeding steering area 3101a is provided on the side of the sample rack storage area 3101 to be measured, which is close to the measuring device 2, and a sample rack discharging steering area 3102a is provided on the side of the measured sample rack storage area 3102, which is close to the measuring device 2. The rack feeding device 32 may transport the rack 80 in the Y2 direction from the rack storage area 3101 to be measured to the rack feeding steering area 3101a under the control of the control device, the rack bidirectional transport device 33 may transport the rack 80 in both directions X1 and X2 between the rack feeding steering area 3101a and the rack feeding-out steering area 3102a under the control of the control device, and the rack feeding device 34 may transport the rack in the Y1 direction from the rack feeding-out steering area 3102a to the measured rack storage area 3102 under the control of the control device.

Fig. 10 is a schematic diagram of the arrangement of functional bits of the sample analyzer 1 according to an embodiment of the present application, including a mix bit 202, a sample bit 203, a wait bit 204, and optionally a code sweep bit 201.

When the automatic sample feeding measurement is started, the control device controls the rack feeding device 32 to first push the racks 80 stored in the rack storage area 3101 to be measured one by one in the Y2 direction to the rack feeding steering area 3101a. The specimen rack 80 entering the specimen rack feeding steering area 3101a is continuously transported in the X1 direction by the specimen rack bidirectional transport device 33 under the control of the control device. The sample containers containing the samples to be tested entering the sample analysis area 3103 are sequentially transported to the mixing position 202 of the measuring device 2 for mixing, and then transported to the sampling position 203 for sampling analysis. Preferably, the sample container entering the sample analysis area 3103 may be transported to the code scanning position 201 for rotating and scanning before being transported to the mixing position 202 for mixing, so as to obtain the characteristic information of the sample in the sample container.

After the sample rack 80 to which the sample container containing the sample to be measured is fixed is transported to the sample rack transport section 3102a by the sample rack bidirectional transport device 33, the sample rack transport device 34 moves the sample rack 80 to the sample rack storage section 3102 under the control of the control device.

When the control device determines that the retest of the measured sample in the sample container fixed to the sample rack 80 at the sample analysis area 3103 is required, the control device may control the sample rack bidirectional transport device 33 to transport the sample rack 80 in the X2 direction. The sample container containing the sample to be re-inspected may be transported back to the sampling site 203 for re-sampling by the sample rack bi-directional transport 33. Preferably, the sample container 80 containing the sample to be re-inspected is transported by the sample rack bi-directional transport device 33 to the blending station 202 for re-blending before being transported by the sample rack bi-directional transport device 33 back to the sampling station 203 for re-sampling. Alternatively, the sample container containing the sample to be re-inspected may be transported by the sample rack bi-directional transport device 33 to the code scanning position 201 for re-scanning and then to the blending position 202 for re-blending before being transported by the sample rack bi-directional transport device 33 back to the sampling position 203 for re-sampling. The sample with completed sampling may wait for the test result at wait bit 204, and wait control means may conclude whether it needs a recheck based on the sample measurement result and a preset recheck rule.

Fig. 11 is a schematic diagram of another functional bit arrangement of the sample analyzer 1 of an embodiment of the present application. Unlike the functional bit arrangement shown in fig. 10, the wait bit 204 is adjacent to the sample bit 203, while in fig. 11, the wait bit 204 is spaced 1 bit from the sample bit 203. In some embodiments, wait bits 204 may also be spaced apart from sample bits 203 by multiple bits or overlap. However, overlapping of the waiting bit 204 with the sampling bit 203 may result in a decrease in the measurement speed of the sample analyzer 1. In the case where the waiting bit 204 does not overlap with the sampling bit 203, that is, the sample at the end of the current sampling waits for the detection result not at the sampling bit but at the waiting bit after the sampling bit, therefore, the sample at the end of the current sampling can continue the sampling measurement while the sample at the waiting bit waits, thereby realizing the speed-up.

Similarly, the code scanning bits 201 may be spaced 1 bit or more from the blending bits 202 or adjacent to the blending bits 202 according to actual requirements.

The "adjacent" means that the fixing holes of the two sample containers corresponding to the functional positions are adjacent to each other on the sample holder 80, the "1-bit interval" means that the two sample containers corresponding to the functional positions are spaced apart by one fixing hole between the fixing holes of the sample holder 80, and the "multi-bit interval" means that the two sample containers corresponding to the functional positions are spaced apart by a plurality of fixing holes between the fixing holes of the sample holder 80. The wait bit 204 may be a specific function bit or may be a single area.

The application also provides a sample detection method with a peripheral blood rechecking function, as shown in fig. 12, the method comprises the following steps:

step S10, conveying the sample container loaded with the sample to be tested to a first mixing position or a second mixing position along a first direction for mixing. In this step, it is possible to determine whether the sample container loaded with the sample to be measured is the first type sample container or the second type sample container, and when the sample container loaded with the sample to be measured is the first type sample container (peripheral blood sample container), the transporting device transports the sample container loaded with the sample to be measured to the first mixing position by the first mixing device; when the sample container loaded with the sample to be measured is a second type of sample container (venous blood sample container), the transporting device transports the sample container loaded with the sample to be measured to a second mixing position and the second mixing device mixes the sample container. The first mixing position and the second mixing position may be the same position or different positions.

And step S12, conveying the sample container loaded with the sample to be tested to a sampling position along the first direction for sampling.

And S14, judging whether the sample to be detected needs rechecking or not according to a sample detection result.

And step S16, when judging that the sample to be detected needs to be rechecked, judging whether the sample container needing rechecked is a first type sample container or a second type sample container. For example, the sample container to be re-inspected can be transported to a code scanning position along the second direction for code scanning so as to judge the type of the sample container to be re-inspected.

Step S18, when the sample container needing to be reexamined is judged to be a first type sample container, conveying the sample container needing to be reexamined to the first blending position along the second direction for blending operation; and when the sample container needing to be rechecked is judged to be the second type sample container, conveying the sample container needing to be rechecked to the second mixing position along the second direction for mixing operation.

Specifically, in step S18, the sample container to be retested may be directly mixed by the first mixing device 21 or the second mixing device in the first mixing position or the second mixing position in the sample rack 80 where the sample container to be retested is located, where the sample rack 80 may be a part of the first mixing device 21 or the second mixing device; alternatively, the sample container to be retested may be carried by the carrying device 22 or another carrying device to another position in the sample analyzer and mixed by the first mixing device 21 or the second mixing device, for example, carried to a fixed position where the mixing device is located or carried to a certain appropriate spatial position above the sample rack space. In some embodiments, the handling device 22 and the second blending device may be the same device or different devices. In other embodiments, the first type of sample container and the first type of sample container may be handled by the same handling device to the respective blending device or by different handling devices, respectively.

And step S20, after the mixing operation of the sample container needing to be re-inspected is completed, conveying the sample rack along the first direction, so that the sample container needing to be re-inspected is conveyed to the sampling position again for sampling.

Advantageously, the first blending location and the second blending location are the same location. In this case, it will be understood by those skilled in the art that step S18 may be performed before step S16, that is, when it is determined that the sample to be tested needs to be retested, the control device controls the sample transporting device to transport the sample container of the sample to be tested to the same blending position along the second direction X2, then the control device determines whether the sample to be tested is a peripheral blood sample or a venous blood sample, when it is determined that the sample to be tested is a peripheral blood sample, the sample container of the sample to be tested may be transported to the first blending device 21 by the transporting device 22 for blending, and when it is determined that the sample to be tested is a venous blood sample, the sample to be tested may be blended by the second blending device.

In addition, the sample detection method shown in fig. 12 may further include: judging whether the sample to be tested is rechecked, and when the sample to be tested is rechecked, not rechecking the sample to be tested.

Specifically, fig. 13 shows a first preferred embodiment of the sample detection method of the present application. Fig. 13 shows a measurement flow through which a measured sample passes since the initiation of an autosample measurement. It should be noted that, the flowchart of fig. 13 does not show the iterative process of measurement, for example, when the previous sample is sampled at the sampling bit, the next sample may be mixed at the mixing bit at the same time, but the iterative process should be a process that is easy to understand in the art.

First, the power supply of the sample analyzer 1 is turned on, and the control device starts initialization. In this initialization step, operations such as program initialization, initialization of the liquid path components of the sample analyzer 1, cleaning of the piping, and resetting of the driving portion are performed.

Next, in step S101, the control device controls the rack feeding device 32 to feed the rack 80, to which the sample container 90 loaded with the sample to be measured is fixed, into the rack feeding steering area 3101a.

In step S102, the control device controls the sample rack bidirectional transport device 33 to send the sample container 90 loaded with the sample to be tested to the code scanning position 201 along the X1 direction for scanning codes. At this time, the code scanner 26 of the sample analyzer 1 scans the sample container 90 loaded with the sample to be measured to obtain characteristic information of the sample to be measured, such as information of a patient.

In step S103, the control device controls the sample rack bidirectional transport device 33 to transport the sample container 90 loaded with the sample to be measured to the mixing position 202 in the X1 direction for the mixing operation. At this time, the transporting device 22 transports the sample container 90 loaded with the sample to be measured from the sample rack 80 to the first mixing device 21 and transports the sample container 90 loaded with the sample to be measured from the first mixing device 21 back to the sample rack 80 after the mixing operation is completed. Preferably, the control device may also determine the type of the sample container 90 loaded with the sample to be measured before this step S103, and determine to which mixing position the sample container loaded with the sample to be measured should be sent and by which mixing device to mix.

In step S104, the control device controls the sample rack bidirectional transport device 33 to transport the sample container 90 loaded with the sample to be measured to the sampling position 203 in the X1 direction for sampling. At this time, the sampling device 23 sucks the sample to be measured under the action of the control device.

In step S105, the control device controls the specimen rack bidirectional transport device 33 to transport the specimen container 90 loaded with the specimen to be tested to the waiting position in the X1 direction, waiting for the specimen detection result. At this time, the sample container after the sample container in which the sample to be measured is loaded may be subjected to the sampling operation and/or the code scanning operation at the same time.

In step S106, the control device determines whether the sample detection result has come out. If the sample detection result of the sample to be detected is out, the step S108 is entered, otherwise, the step S107 is entered to continue waiting for the result, and at this time, the sample container after the sample container of the sample to be detected is loaded can still continue the sampling operation and/or the code scanning operation at the same time.

In step S108, the control device determines whether the sample to be tested is rechecked. If the sample to be detected is already rechecked, the rechecked sample is not carried out any more, the detection of the sample to be detected is finished, and the subsequent sample measurement is continued (S111); if the sample to be tested is not retested, step S109 is performed.

In step S109, the control device determines whether the sample detection result of the sample to be detected triggers a re-detection rule. If the control device determines that the sample to be tested needs to be rechecked, the step S110 is entered, and if not, the detection of the sample to be tested is ended, i.e. the step S111 is completed.

In step S110, the control device controls the specimen rack bidirectional transport device 33 to transport the specimen container 90 loaded with the specimen to the mixing position in the X2 direction opposite to the X1 direction. At this time, similarly, the transporting device 22 transports the sample container 90 loaded with the sample to be measured from the sample rack 80 to the first mixing device 21 and transports the sample container 90 loaded with the sample to be measured from the first mixing device 21 back to the sample rack 80 after the mixing operation is completed. It is also preferable that the type of the sample container 90 loaded with the sample to be measured is judged by the control means before this step S110, and it is decided to which mixing position the sample container loaded with the sample to be measured should be sent to and mixed by which mixing means.

Steps S104-S111 are repeated after step S110 until the detection of the sample to be detected is completed.

Fig. 14 shows a second preferred embodiment of the sample detection method of the present application. Unlike the first preferred embodiment shown in fig. 13, when it is determined that the re-inspection is required, in step S110a, the control device controls the sample rack bidirectional transport device 33 to directly transport the sample container 90 loaded with the sample to be tested to the sampling position 203 in the X2 direction opposite to the X1 direction for sampling without re-mixing. This solution is also possible. The re-mixing of the sample to be re-checked is to consider that the sample to be re-checked has sedimentation of blood cells in the process of waiting for the measurement result, and if the re-mixing is not performed, the re-checking result may deviate. However, as long as the waiting time for the measurement result is less than the predetermined threshold, the blood cell sedimentation degree is within an acceptable range, the influence on the retest result is not great, and a scheme of directly returning to the sampling position for sampling without remixing can be adopted.

Fig. 15 shows a third preferred embodiment of the sample detection method of the present application. Unlike the first preferred embodiment shown in fig. 13, when it is determined that the re-inspection is required, in step S110b, the control device controls the sample rack bidirectional conveying device 33 to convey the sample container 90 loaded with the sample to be tested to other positions along the X2 direction opposite to the X1 direction, where the "other positions" may refer to code scanning positions, other positions without specific functions, or a combination state, such as scanning codes from the code scanning positions first and then mixing the samples to the mixing positions; or firstly, the mixture reaches a position without a specific function, and then is uniformly mixed at a uniform mixing position; or firstly, the position without specific function is reached, then the code scanning position is reached, and finally the mixing position is reached for uniform mixing.

Fig. 16 shows a fourth preferred embodiment of the sample detection method of the present application. Unlike the first preferred embodiment shown in fig. 13, step S108 in the embodiment shown in fig. 13 is before step S106 in the embodiment of fig. 16, that is, if the current sample has been retested, it is determined that there is no need to retest the sample. This can save the waiting time of the re-inspected sample and shorten the waiting time of the subsequent sample to be tested.

Possible variants also include the cross-combinations of fig. 16 with fig. 14 and 15, which are not listed here.

The review process shown in fig. 13 to 16 may be a single-function sample analyzer for automatic peripheral blood batch measurement or automatic venous blood batch measurement, or a multi-function integrated sample analyzer having both automatic peripheral blood batch measurement and automatic venous blood batch measurement.

In the case of an automatic batch measurement single-function sample analyzer for peripheral blood, the sample analyzer 1 mixes the samples in the peripheral blood sample container 90 by using only the first mixing device 21.

For a multifunctional integrated sample analyzer having both automatic peripheral blood measurement and automatic venous blood batch, the sample analyzer 1 mixes the samples in the peripheral blood sample container 90 by the first mixing device 21 and mixes the samples in the venous blood sample container 91 by the second mixing device 22. The sample analyzer 1 may acquire the bar code of the sample rack 80 through the bar code scanner 26 to determine which mixing device to use for mixing the sample containers fixed to the sample rack 80.

As shown in fig. 17, the first mixing device 21 according to the present invention includes a holder 211, a sample container holder 212, a motor 213, and a sensor 214. The bracket 211 is used to fix the motor 213 and the sensor 214. The motor 213 is used as a power source to drive the sample container holder 212 to rotate clockwise or counterclockwise. The sensor 214 is used to detect whether the sample container holder 212 is rotated or not, and to detect the rotational speed of the sample container holder 212. The sample container holder 212 is rotatably connected to the stepper motor 213, and the sample container holder 212 may be directly fixed to the rotation shaft of the motor 213. As shown in fig. 18, a sample container holding chamber 2121 is provided on the top of the sample container holder 212, and the sample-containing peripheral blood sample container 90 can be placed in the sample-containing container holding chamber 2121.

A sensor sensing portion 2124 and a notch 2125 are provided below the sample vessel holder 212. When the sample container fixing base 212 rotates, the sensor sensing portion 2124 and the notch 2125 can circularly and alternately enter the sensing area of the sensor 214, the sensing area of the sensor 214 can be alternately switched between the shielding state and the non-shielding state, the output end of the sensor 214 correspondingly outputs the pulse as shown in (a) or (b) of fig. 19, whether the sample container fixing base 212 rotates can be judged by detecting whether the sensor 214 outputs the pulse signal, whether the rotation number of the sample container fixing base 212 accords with the expectation can be known by detecting the number of the pulse signals outputted by the sensor 214, and whether the rotation speed of the sample container fixing base 212 accords with the expectation can be calculated by detecting the pulse signal period T shown in fig. 19.

The internal structure of the sample container holder 212 is shown in fig. 20. The top of the sample container holder 212 is provided with a sample container receiving chamber 2121, and the diameter of the sample container receiving chamber 2121 at the entrance is slightly larger than the outer diameter of the peripheral blood sample container 90. Below the sample container receiving chamber 2121, a sample container abutting portion 2122 is provided, and a motor shaft fixing hole 2123 is provided in the bottom of the sample container fixing base 212. The motor shaft fixing hole 2123 is for connection with the shaft of the motor 213. The axis A1 of the motor shaft fixing hole 2123 is the rotation axis of the sample container fixing base 212. As shown in fig. 20, the axis A1 of the motor shaft fixing hole 2123 and the central axis A2 of the sample container holding cavity 2121 may not coincide, i.e., the sample container holding cavity 2121 may be eccentrically disposed with respect to the shaft of the sample container fixing base 212, and the eccentric amount d may be 0mm to 5mm, preferably ranges from 1mm to 2mm.

The function of the sample container abutment 2122 is to keep the peripheral blood sample container 90 placed in the sample container receiving chamber 2121 inclined as shown in fig. 21. At this time, the rotation axis A1 of the sample container holder 212 intersects with the central axis A3 of the peripheral blood sample container 90, and the included angle between the axis A1 and the axis A3 is α, where α may be 0 ° < α+.ltoreq.45°, and preferably ranges from 2 ° to 10 °. The intersection point P of axis A1 and axis A3 is located above the bottom of the sample chamber of the peripheral blood sample container 90.

When the sample container holder 212 rotates about the axis A1, the blood sample 100 in the peripheral blood sample container 90 is thrown off the axis A1 of the sample container holder 212 by centrifugal force and rises along the inner wall of the cavity of the peripheral blood sample container 90.

Referring to fig. 22, a stress analysis is performed on a sample on the inner wall of the cavity of the distal blood sample container 90 as follows: according to the principle of force and reaction force, the sample cell S located on the inner wall of the cavity of the peripheral blood sample container 90 is subjected to a force F perpendicular to the inner wall, which force F may be decomposed into force components F1 and F2, wherein f1=fcos α, f2=fsin α, further f2=f1 tan α. Force F1 provides a centripetal force that rotates sample unit S about axis A1, while force F2 may prevent sample unit S from rising along the inner wall of the cavity of peripheral blood sample container 90.

According to the centripetal force formula: f1 =Δmω ² r, where F1 is the centripetal force required for rotation of the sample unit S about the axis A1, Δm is the mass of the sample unit S, ω is the angular velocity of rotation of the sample unit S about the axis A1, and r is the radius of rotation of the sample unit S about the axis A1. The centripetal force F1 is proportional to the square of the angular velocity ω of the sample unit S rotating around the axis. As is well known, due to the fluidity of the liquid, the greater the angular velocity ω at which the liquid rotates, the greater the tendency of the liquid to leave the center of rotation, i.e., the tendency of the sample cell S to rise along the inner wall of the cavity of the peripheral blood sample container 90 The potential increases as the angular velocity ω of its pivoting increases. But further deriving that f2=Δmω ² As the angular velocity ω increases, the force F2 that resists the rise of the sample cell S along the inner wall of the cavity of the peripheral blood sample container 90 increases, counteracting the tendency of the sample cell S to rise along the inner wall of the cavity of the peripheral blood sample container 90. The angular velocity omega and the included angle alpha are reasonably balanced, so that the angular velocity omega not only can meet the requirement of sample uniform mixing, but also can control the liquid level height of the sample during rotation by adjusting the included angle alpha, and finally, dynamic balance is achieved. That is, the sample unit S can not only rotate circumferentially at an angular speed ω along the axis of rotation A1, but also prevent the liquid level from rising too high, so that the sample is prevented from overflowing the peripheral blood sample container 90, and the amount of liquid hanging residue of the sample 100 on the inner wall of the cavity of the peripheral blood sample container 90 is reduced by suppressing the liquid level when the sample rotates, thereby reducing the sample loss.

The above method rotates the peripheral blood sample container 90 containing the sample 100 by the sample container holder 212, and generates a mixing force of the sample 100 by the rotation. When the sample container holder 212 rotates, the sample 100 rotates along the inner wall of the cavity of the peripheral blood sample container 90; when the sample container holder 212 stops rotating, sample that had previously risen to the side wall of the cavity of the peripheral blood sample container 90 flows back to the bottom of the peripheral blood sample container 90. The sample 100 is evenly mixed through the rotary motion of the sample 100 and the climbing motion and the backflow motion of the sample 100. As described above, when the sample 100 in the peripheral blood sample container 90 is mixed, the peripheral blood sample container 90 is inclined, and the intersection point of the axis A1 of the sample container holder 212 and the axis A3 of the peripheral blood sample container 90 is located above the bottom of the sample chamber of the peripheral blood sample container 90, so that the effect of preventing the sample from spilling and the effect of reducing the wall-hanging loss during the mixing of the sample 100 can be achieved, which is extremely important for the peripheral blood sample with a small blood collection amount because the excessive wall-hanging loss affects the reliability of the sample after the mixing.

The second mixing device 22 according to the present application is shown in fig. 23. The clamping jaw 221 of the second mixing device 22 can realize linear motion along the Y1 or Y2, Z1 or Z2 direction and can swing along the R1 or R2 direction around the shaft under the driving of the plurality of driving sources of the second mixing device 22. Preferably, the second mixing device 22 may be used as a handling device for a peripheral blood sample container.

As shown in fig. 24, fig. 24 is a schematic diagram of a mixing flow of venous blood samples.

In step S201, the mixing counter is cleared to 0 before mixing starts.

In step S202, the clamping jaw 221 of the second mixing device 22 is extended in the Y1 direction to a front position to clamp the venous sample container.

In step S203, the clamping jaw 221 of the second mixing device 22 is lifted in the Z1 direction with the venous sample container, so that the venous sample container is separated from the sample holder 80.

In step S204, the clamping jaw 221 of the second mixing device 22 rotates the venous sample container in the direction R1.

In step S205, the clamping jaw 221 of the second mixing device 22 is stopped for a time T1, so that the blood sample in the venous sample container has enough time to flow in the direction of the cuvette cap.

In step S206, the clamping jaw 221 of the second mixing device 22 rotates the venous sample container along the direction R2, so that the venous sample container returns to the upright direction, and the blood sample in the venous sample container flows along the tube wall towards the bottom of the test tube under the action of gravity.

In step S207, the clamping jaw 221 of the second mixing device 22 stays for a time T2, so that the blood sample in the venous sample container has enough time to flow to the bottom direction of the test tube, and T2 may be equal to T1 or may not be equal to T1.

In step S208, the number of times the blending counter of the second blending device counts is increased by 1 (each time the loop is executed in steps S204 to S207, it is regarded that the reverse blending is completed once), and then the process goes to step S209.

In step S209, the control device determines whether the number of blending operations of the sample has reached N, and if not, jumps to step S204 to execute the blending cycle operation once again, and if the number of blending operations has reached N, jumps to step S210; in addition, N is usually 8 to 12, preferably 10 times.

In step S210, the clamping jaw 221 of the second mixing device 22 is lowered in the Z2 direction with the venous sample container, and the venous sample container is returned to the sample holder 80.

In step S211, the clamping jaw 221 of the second mixing device 22 is retracted in the Y2 direction out of the venous sample container.

As shown in fig. 25, fig. 25 is a schematic of the mixing flow of the peripheral blood sample.

In step S301, the clamping jaw 221 of the second mixing device 22 is extended in the Y2 direction to clamp a peripheral blood sample container from the sample holder.

In step S302, the clamping jaw 221 of the second mixing device 22 is lifted off the sample holder 80 in the Z1 direction with the distal blood sample container in between.

In step S303, the clamping jaw 221 of the second mixing device 22 is moved a distance in the Y2 direction, so that the distal blood sample container is moved directly above the sample container holder 212 of the first mixing device 21.

In step S304, the clamping jaw 221 of the second mixing device 21 is lowered in the Z2 direction and the peripheral blood sample container is placed in the sample container holder 212 of the first mixing device 21.

In step S305, the clamping jaw 221 of the second mixing device 21 is retracted in the Y2 direction out of the peripheral blood sample container; in step S305, the operation of transporting the peripheral blood sample container to the first mixing device 11 is completed.

In step S306, the first mixing device 21 mixes the sample in the peripheral blood sample container. The stepper motor 213 of the first mixing device 21 drives the sample container receptacle 212 to rotate the distal blood sample container.

In step S307, the control device determines whether or not the first mixing device 21 has completed mixing the sample in the peripheral blood sample container, and if so, jumps to step S308, otherwise, in step S307, the mixing of the first mixing device 21 is waited for.

In step S308, the clamping jaw 221 of the second mixing device 22 is extended in the Y1 direction to clamp the peripheral blood sample container.

In step S309, the clamping jaw 221 of the second mixing device 22 is lifted off the sample container holder 212 of the first mixing device 21 with the distal blood sample container in the Z1 direction.

In step S310, the clamping jaw 221 of the second mixing device 22 is moved a certain distance in the Y1 direction, so that the distal blood sample container is moved directly above the sample container holder 212 of the first mixing device 21.

In step S311, the clamping jaw 221 of the second mixing device 22 is lowered in the Z2 direction, and the peripheral blood sample container is returned to the sample rack.

In step S312, the clamping jaw 221 of the second mixing device 22 is retracted in the Y2 direction out of the peripheral blood sample container; ending the process to step S312, completing the operation of transporting the peripheral blood sample container back to the sample rack, and ending the flow; it can be seen that steps S308 to S312 are the inverse of steps S301 to S305.

The blending flow of fig. 24 and 25 may be applied to the blending step in the method shown in fig. 12 to 16.

As shown in fig. 26, the present application also provides a control device 400 for a sample analyzer, the control device 400 comprising at least one processor 401 and a memory 402, the memory 402 storing instructions executable by the at least one processor 401, which instructions, when executed by the at least one processor 401, cause the sample analysis system to perform the steps of the above-described method.

The control device 400 may further comprise at least one network interface 404 and a user interface 403. The various components in the control device 400 are coupled together by a bus system 405. It is understood that the bus system 405 is used to enable connected communications between these components. The bus system 405 includes a power bus, a control bus, and a status signal bus in addition to a data bus. But for clarity of illustration the various buses are labeled as bus system 405 in fig. 26.

The user interface 403 may include, among other things, a display, keyboard, mouse, trackball, click wheel, keys, buttons, touch pad, or touch screen, etc.

It is to be appreciated that memory 402 can be either volatile memory or nonvolatile memory, and can include both volatile and nonvolatile memory. Wherein the nonvolatile Memory may be Read Only Memory (ROM), programmable Read Only Memory (PROM, programmable Read-Only Memory), erasable programmable Read Only Memory (EPROM, erasable Programmable Read-Only Memory), electrically erasable programmable Read Only Memory (EEPROM, electrically Erasable Programmable Read-Only Memory), magnetic random access Memory (FRAM, ferromagnetic random access Memory), flash Memory (Flash Memory), magnetic surface Memory, optical disk, or compact disk Read Only Memory (CD-ROM, compact Disc Read-Only Memory); the magnetic surface memory may be a disk memory or a tape memory. The volatile memory may be random access memory (RAM, random Access Memory), which acts as external cache memory. By way of example, and not limitation, many forms of RAM are available, such as static random access memory (SRAM, static Random Access Memory), synchronous static random access memory (SSRAM, synchronous Static Random Access Memory), dynamic random access memory (DRAM, dynamic Random Access Memory), synchronous dynamic random access memory (SDRAM, synchronous Dynamic Random Access Memory), double data rate synchronous dynamic random access memory (ddr SDRAM, double Data Rate Synchronous Dynamic Random Access Memory), enhanced synchronous dynamic random access memory (ESDRAM, enhanced Synchronous Dynamic Random Access Memory), synchronous link dynamic random access memory (SLDRAM, syncLink Dynamic Random Access Memory), direct memory bus random access memory (DRRAM, direct Rambus Random Access Memory). The memory 402 described herein is intended to comprise these and any other suitable types of memory.

Memory 402 in this application includes, but is not limited to: the ternary content addressable memory, static random access memory, can store a variety of types of data, such as received sensor signals, to support operation of the control apparatus 400.

The processor 401 of the present application may be a central processing unit (Central Processing Unit, CPU, but also other general purpose processor, digital signal processor (Digital Signal Processor, DSP), application specific integrated circuit (Application Specific Integrated Circuit, ASIC), off-the-shelf programmable gate array (Field-Programmable Gate Array, FPGA) or other programmable logic device, discrete gate or transistor logic device, discrete hardware components, etc. a general purpose processor may be a microprocessor or the processor may also be any conventional processor, etc.

The present application also provides a computer readable storage medium, such as a memory 402, comprising a computer program executable by the processor 401 of the controller 400, such that the sample analysis system performs the steps of the sample homogenization method. The computer readable storage medium may be FRAM, ROM, PROM, EPROM, EEPROM, flash Memory, magnetic surface Memory, optical disk, or CD-ROM; but may be a variety of devices including one or any combination of the above memories.

The above-mentioned features can be combined with one another at will as far as they are interesting within the scope of the present application. The advantages and features described for the sample analyzer apply in a corresponding manner to the sample detection method and the control device.

While specific embodiments of the present application are described above, it will be appreciated by those skilled in the art that these specific embodiments are illustrative only. Those skilled in the art may make numerous variations or modifications to these specific embodiments without departing from the principles of the present application, and such variations and modifications are within the scope of the present application.

Claims

1. A sample analyzer, comprising:

a sample transport means arranged to transport a sample rack loaded with sample containers in a first direction or in a second direction opposite to the first direction;

a first mixing device configured to perform a mixing operation on a first type of sample container containing a trace amount of blood sample, the first mixing device including a sample container holder provided with a sample container accommodation chamber, the sample container holder being rotated about a rotational axis thereof by a power source, the sample container holder further including an abutment portion provided in the sample container accommodation chamber, the abutment portion being configured to maintain the sample container in a tilted state with respect to the rotational axis of the sample container holder when the sample container is fixedly placed in the sample container accommodation chamber, the abutment portion being located at a bottom of the sample container accommodation chamber such that a protrusion for pushing the sample container placed in the sample container accommodation chamber toward the other side is formed on one side of the bottom of the sample container accommodation chamber;

The second mixing device is used for carrying out mixing operation on a second type of sample container filled with a constant blood sample;

sampling means arranged to sample a sample in a sample container;

a detection device configured to detect the sucked sample;

control means arranged to:

controlling the sample conveying device to convey the sample container loaded with the sample to be tested to a first mixing position or a second mixing position along the first direction for mixing;

controlling the sample conveying device to convey a sample container loaded with a sample to be tested to a sampling position along the first direction for sampling;

judging whether the sample to be detected needs rechecking;

when the sample to be detected is judged to need rechecking, the sample transporting device is controlled to transport the sample rack along the second direction, so that the sample container needing rechecking is transported to the sampling position again for sampling.

2. The sample analyzer of claim 1, wherein the control device is configured to determine whether the sample container requiring re-inspection needs to be re-homogenized before re-sampling based on a waiting time determined by waiting for re-inspection of the sample container requiring re-inspection at a waiting position when the sample to be measured is determined to require re-inspection.

3. The sample analyzer of claim 2, wherein the wait position is adjacent to or one bit apart from the sampling position.

4. The sample analyzer of claim 2, wherein the wait position is spaced apart from the sample position by a multiple of bits or overlaps.

5. The sample analyzer of claim 2, wherein the control device is configured to:

when the sample container needing rechecking is judged to be uniformly mixed again, judging whether the sample container needing rechecking is a first type sample container or a second type sample container;

when the sample container needing to be reexamined is judged to be a first type sample container, controlling the sample transporting device to transport the sample container needing to be reexamined to the first blending position along the second direction and controlling the first blending device to blend the sample container needing to be reexamined; when the sample container needing to be reexamined is a second type of sample container, controlling the sample transporting device to transport the sample container needing to be reexamined to the second blending position along the second direction and controlling the second blending device to blend the sample container needing to be reexamined;

After the mixing operation of the sample container needing to be reexamined is completed, the sample transporting device is controlled to transport the sample rack along the first direction, so that the sample container needing to be reexamined is transported to the sampling position again for sampling.

6. A sample analyzer, comprising:

sampling means arranged to sample a sample in a sample container;

a detection device configured to detect the sucked sample;

control means arranged to:

judging whether the sample to be detected needs rechecking;

when judging that the sample to be detected needs to be rechecked, judging whether the sample container needing rechecked is a first type sample container or a second type sample container;

7. The sample analyzer of any one of claims 1-6, wherein the first mixing location and the second mixing location are the same location or different locations.

8. The sample analyzer of any one of claims 1-6, wherein the abutment comprises at least one sloped surface extending from a sidewall of the sample container receiving chamber toward the bottom.

9. The sample analyzer of any one of claims 1-6, wherein the axis of rotation of the sample container mount and the central axis of the sample container receiving cavity do not coincide.

10. A method for sample detection, comprising the steps of:

the method comprises the steps of conveying a first type of sample container loaded with a trace amount of blood sample to a first mixing position along a first direction, and driving the first type of sample container to rotate in a mode of forming an included angle with a rotation axis of the sample container fixing seat through the sample container fixing seat, so that the trace amount of blood sample in the first type of sample container can be uniformly mixed through rising along the inner wall of the containing cavity under the double action of centrifugal force and reaction force of the inner wall of the containing cavity, and the rising height along the inner wall of the containing cavity can be restrained;

Conveying the second type sample container loaded with the constant blood sample to a second mixing position along the first direction for mixing;

transporting the sample container loaded with the sample to be tested to a sampling position along the first direction for sampling;

judging whether the sample to be detected needs rechecking;

when the sample container needing rechecking is judged to be a first type sample container, conveying the sample container needing rechecking which is positioned at the downstream of the sampling position along the first direction to the first mixing position along a second direction opposite to the first direction for mixing operation; when the sample container needing rechecking is judged to be a second type sample container, conveying the sample container needing rechecking which is positioned at the downstream of the sampling position along the first direction to the second mixing position along the second direction for mixing operation;

after the mixing operation of the sample container needing to be reexamined is completed, the sample container is conveyed along the first direction, so that the sample container needing to be reexamined is conveyed to the sampling position again for sampling.

11. A method of sample detection comprising the steps of:

judging whether the sample to be detected needs rechecking;

and when judging that the sample to be detected needs to be rechecked, conveying the sample container along a second direction opposite to the first direction, so that the sample container which is positioned at the downstream of the sampling position along the first direction and needs to be rechecked is conveyed to the sampling position again for sampling.

12. The sample detection method according to claim 10 or 11, wherein the first mixing position and the second mixing position are the same position or different positions.

13. A control device for a sample analyzer, comprising:

at least one processor; and

a memory storing instructions executable by the at least one processor, which when executed by the at least one processor, cause the sample analyzer to perform the method of claim 10 or 11.

14. A computer-readable storage medium storing computer-executable instructions that, when executed by at least one processor of a sample analyzer, cause the sample analyzer to a method according to claim 10 or 11.