CN111719196A

CN111719196A - Composite antibacterial fiber and preparation method thereof

Info

Publication number: CN111719196A
Application number: CN202010757917.1A
Authority: CN
Inventors: 储旭
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-07-31
Filing date: 2020-07-31
Publication date: 2020-09-29

Abstract

The invention discloses a composite antibacterial fiber and a preparation method thereof. The composite antibacterial fiber is prepared from 0.1-0.5 wt% of gallium nitrate, 0.5-2.0 wt% of zinc oxide, 2.0-3.0 wt% of gelatin, 10-20 wt% of polyvinyl alcohol and the balance of water by a conventional method. The composite antibacterial fiber has good antibacterial performance, and particularly has more prominent antibacterial and bacteriostatic effects on Klebsiella pneumoniae.

Description

Composite antibacterial fiber and preparation method thereof

Technical Field

The invention relates to a fiber and a preparation method thereof, in particular to a composite antibacterial fiber and a preparation method thereof.

Background

Microorganisms are closely related to people's daily life. On one hand, human beings use biotechnology to apply certain microorganisms to fermentation industry, biological pesticides and bacterial manure work; probiotics in the human body provide life-necessary substances or help the human body to absorb nutrients through metabolism. On the other hand, some microorganisms are pathogenic bacteria. The spread of pathogenic bacteria poses a great threat to human health and personal safety.

In recent years, people have higher and higher requirements on the comfort, health, safety, environmental protection and the like of garment materials, and have more and more requirements on the functions of safe and efficient antibacterial clothes; in life, people inevitably come into contact with various microorganisms such as bacteria and fungi, and the microorganisms can rapidly propagate under proper external conditions and spread diseases by means of contact and the like, so that the physical health and normal work, study and life of people are influenced. The fiber belongs to a porous material, and a multilayer body with countless gaps is formed after the fiber is overlapped and woven, so that the fabric can easily absorb bacteria. The antibacterial finishing is to make the fabric have the function of inhibiting the growth of bacteria, maintain the sanitary living environment of the clothes and ensure the health of human body. The use of antibacterial agents originated during world war ii when the German force had greatly reduced the bacterial infections of victims by wearing antibacterial military uniforms. In the last 60 th century, people mostly adopt organic antibacterial agents to produce antibacterial textiles; in the 21 st century, with the advent of the aging society, the number of bedridden people and home patients who are nursing at home has increased, and the demand for nursing articles for the elderly to prevent bedsores has also increased. Due to the change from the society with production as the main part to the concept with living as the main part, the development and research of products which are beneficial to the health of human bodies and the global environment, the antibacterial fabrics/fabrics are increasingly paid more attention by people. Therefore, the development of the fabric which is environment-friendly, safe and has excellent antibacterial performance is of great significance.

Klebsiella pneumoniae is the most important group of klebsiella pneumoniae of enterobacteriaceae (commonly known as pneumoconiosis), and has the scientific name: klebsiella Pneumoniae, the disease caused by which accounts for over 95% of Klebsiella infection.

It exists in the upper respiratory tract and intestinal tract of human body, and when the resistance of human body is reduced, it can enter into lung through respiratory tract to cause the fusion of large leaf and small leaf, and the above leaves are more common.

Klebsiella pneumoniae, the exudate from pathological changes is sticky and heavy, causing the space between the leaves to descend. The bacteria have a capsule and when growing and multiplying in the alveoli, cause tissue necrosis, liquefaction, and the formation of single or multiple abscesses. When the pleural and pericardial diseases are involved, exudative or purulent fluid accumulation may occur. The fibrous tissue of the focus is proliferated actively and is easy to organize; cellulosic pleural effusions can develop adhesions early. In hospital-infected septicemia, klebsiella is an important pathogen and the mortality rate is high.

CN107587252A provides a zinc oxide/gelatin/polyvinyl alcohol composite antibacterial fiber, which has good antibacterial effect on escherichia coli, staphylococcus aureus and bacillus subtilis, but is not ideal for klebsiella pneumoniae.

The antibacterial fiber and the antibacterial fabric in the prior art have very limited antibacterial effect on klebsiella pneumoniae, so that a textile with high-efficiency resistance to klebsiella pneumoniae needs to be further developed.

Disclosure of Invention

In order to achieve the purpose, the invention provides the composite antibacterial fiber which has good anti-Klebsiella pneumoniae antibacterial performance.

A composite antibacterial fiber is prepared from gallium nitrate, zinc oxide, gelatin, polyvinyl alcohol and water by conventional method.

The composite antibacterial fiber is prepared from 0.1-0.5 wt% of gallium nitrate, 0.5-2.0 wt% of zinc oxide, 2.0-3.0 wt% of gelatin, 10-20 wt% of polyvinyl alcohol and the balance of water by a conventional method.

The composite antibacterial fiber is prepared from 0.1-0.5 wt% of gallium nitrate, 0.5-1.5 wt% of 8-hydroxyquinoline copper, 0.5-2.0 wt% of zinc oxide, 2.0-3.0 wt% of gelatin, 10-20 wt% of polyvinyl alcohol and the balance of water by a conventional method.

The invention also provides a preparation method of the composite antibacterial fiber, which comprises the following steps: heating water to 65-75 ℃, adding gelatin and polyvinyl alcohol, mixing uniformly, adding gallium nitrate, zinc oxide and 8-hydroxyquinoline copper (if the formula is available), stirring and mixing uniformly, standing and defoaming to obtain a spinning stock solution;

wet spinning, drafting, drying and heat setting.

Preferably, the spinning solution is subjected to conventional wet spinning, the temperature of a coagulation bath is 45 ℃, and semi-finished fibers are obtained through drafting, drying and heat setting; and then the semi-finished fiber is washed, dried and cut to prepare the composite antibacterial fiber.

Although Klebsiella pneumoniae and Escherichia coli are both gram-negative bacteria, the antibacterial mechanism is not the same, and the antibacterial agent is not applicable.

Gallium nitrate belongs to an inorganic antibacterial agent, has the characteristics of the inorganic antibacterial agent, and has an antibacterial mechanism different from that of a common antibiotic. Pathogenic microorganisms typically grow attached to biofilms. The existence of the biological membrane can prevent the antibacterial drug from directly contacting with pathogenic bacteria, so that the drug can not exert the antibacterial effect. First, iron is essential for the growth and development of all pathogenic bacteria and is involved in DNA synthesis, oxidative stress defense mechanisms, ion transfer, and other processes. Second, many host defense mechanisms require iron ions, and iron deficiency can cause acute and chronic infections. In preventing acute infections, iron limitation is crucial and in many studies, over 18 different bacteria, increasing iron content can significantly reduce their resistance to acute infections. Studies have shown that high concentrations of iron are of great significance for early biofilm growth and colony formation during biofilm maturation (conversion to three-dimensional structures). Maintaining the iron concentration at a constant value may be protective during infection of the host by pathogenic bacteria. The iron chelator treatment experimental results show that certain organisms chelate iron with a chelator, gallium ions which cause secondary infection have ion radii similar to that of the iron ions, and the organisms may not distinguish the iron ions from the gallium ions, so that the gallium ions may have a competitive relationship with the iron ions and enter pathogenic bacteria in competition with iron, and the iron chelator treatment experimental results particularly effectively block metabolic processes involved by the iron ions against klebsiella pneumoniae, thereby showing antibacterial performance, while the blocking effect against escherichia coli is not obvious.

The 8-hydroxyquinoline copper belongs to a heterocyclic organic antibacterial agent with a benzo six-membered ring, is a typical chelate, is an excellent sterilizing, disinfecting and mildew-proof agent, and has toxicity: the oral administration of LD5015000mg/kg to mice is harmless to human and livestock, and the sterilization mechanism is systemic, osmotic and has good safety, and the traditional method is mainly used for preventing mildew of textiles. The antibacterial and bacteriostatic effects against escherichia coli and klebsiella pneumoniae are not reported.

Through research and analysis, the inventor firstly applies the 8-hydroxyquinoline copper to the antibacterial fiber for resisting and inhibiting bacteria of escherichia coli and klebsiella pneumoniae, and finds that the antibacterial fiber has obvious effect on resisting and inhibiting bacteria of klebsiella pneumoniae.

The zinc oxide has good ultraviolet shielding property and excellent antibacterial and bacteriostatic properties, and can endow the fabric with functions of sun protection, antibiosis, deodorization and the like when added into the fabric.

According to the invention, gallium nitrate, 8-hydroxyquinoline copper and zinc oxide are combined, an organic antibacterial agent and an inorganic antibacterial agent are combined, and the antibacterial effect of Klebsiella pneumoniae is synergistic.

The composite antibacterial fiber has good antibacterial performance, and particularly has more prominent antibacterial and bacteriostatic effects on Klebsiella pneumoniae.

Detailed Description

Zinc oxide: average particle size of 20 + -5 nm, Shanghai Allantin Biotechnology Co., Ltd;

gelatin: CAS number: 9000-70-8, Jiangsu Yuan Shengtong bioengineering Co., Ltd, a product number 1087 gelatin;

polyvinyl alcohol, CAS No.: 9002-89-5, and 088-50 parts of medium petrochemical great wall energy chemical PVA.

Gallium nitrate, english name: galliumnitrate, CAS No.: 13494-90-1.

Copper 8-hydroxyquinoline, english name: copperquinone, CAS No.: 10380-28-6.

In the examples and comparative examples, other parameters not specifically described were the same, thereby ensuring comparability between specific embodiments.

The test method comprises the following steps: the national standard GB/T20994.3-2008' evaluation part 3 of antibacterial performance of textiles: the oscillation method carries out antibacterial property quantitative test on the composite antibacterial fiber, tests the antibacterial rate of the fiber which is not washed by water, and samples: 0.75 g of composite antibacterial fiber, strain: coli ATCC11229, klebsiella pneumoniae ATCC 4352.

Example 1

A composite antibacterial fiber comprises the following raw materials: 0.1 wt% of gallium nitrate, 1.3 wt% of zinc oxide, 2.5 wt% of gelatin, 18 wt% of polyvinyl alcohol and the balance of water.

Heating water to 70 ℃, adding gelatin and polyvinyl alcohol, uniformly mixing, adding gallium nitrate and zinc oxide, uniformly stirring and mixing, standing and defoaming to obtain a spinning solution;

wet spinning the spinning solution at a coagulation bath temperature of 45 ℃ to obtain semi-finished fibers through drafting, drying and heat setting; and then the semi-finished fiber is washed, dried and cut to prepare the composite antibacterial fiber.

Example 2

A composite antibacterial fiber comprises the following raw materials: 0.3 wt% of gallium nitrate, 1.3 wt% of zinc oxide, 2.5 wt% of gelatin, 18 wt% of polyvinyl alcohol and the balance of water.

Example 3

A composite antibacterial fiber comprises the following raw materials: 0.5 wt% of gallium nitrate, 1.3 wt% of zinc oxide, 2.5 wt% of gelatin, 18 wt% of polyvinyl alcohol and the balance of water.

Example 4

A composite antibacterial fiber comprises the following raw materials: 0.1 wt% of gallium nitrate, 1.2 wt% of 8-hydroxyquinoline copper, 1.3 wt% of zinc oxide, 2.5 wt% of gelatin, 18 wt% of polyvinyl alcohol and the balance of water.

Heating water to 70 ℃, adding gelatin and polyvinyl alcohol, uniformly mixing, adding gallium nitrate, zinc oxide and 8-hydroxyquinoline copper, uniformly stirring and mixing, standing and defoaming to obtain a spinning stock solution;

Example 5

A composite antibacterial fiber comprises the following raw materials: 0.3 wt% of gallium nitrate, 1.0 wt% of 8-hydroxyquinoline copper, 1.3 wt% of zinc oxide, 2.5 wt% of gelatin, 18 wt% of polyvinyl alcohol and the balance of water.

Example 6

A composite antibacterial fiber comprises the following raw materials: 0.5 wt% of gallium nitrate, 0.8 wt% of 8-hydroxyquinoline copper, 1.3 wt% of zinc oxide, 2.5 wt% of gelatin, 18 wt% of polyvinyl alcohol and the balance of water.

Example 7

A composite antibacterial fiber comprises the following raw materials: 1.3 wt% of gallium nitrate, 1.3 wt% of zinc oxide, 2.5 wt% of gelatin, 18 wt% of polyvinyl alcohol and the balance of water.

Escherichia coli ATCC11229 and Klebsiella pneumoniae ATCC4352 have 69.3% and 87.5% respectively.

Example 8

A composite antibacterial fiber comprises the following raw materials: 1.3 wt% of 8-hydroxyquinoline copper, 1.3 wt% of zinc oxide, 2.5 wt% of gelatin, 18 wt% of polyvinyl alcohol and the balance of water.

Heating water to 70 ℃, adding gelatin and polyvinyl alcohol, uniformly mixing, adding zinc oxide and 8-hydroxyquinoline copper, uniformly stirring and mixing, standing and defoaming to obtain a spinning stock solution;

The bacteriostasis rate of escherichia coli ATCC11229 is 53.8%, and the bacteriostasis rate of Klebsiella pneumoniae ATCC4352 is 65.1%.

Test example 1

The national standard GB/T20994.3-2008' evaluation part 3 of antibacterial performance of textiles: the vibration method carries out antibacterial property quantitative test on the composite antibacterial fiber, tests the antibacterial rate of the fiber without washing, and samples: 0.75 g of composite antibacterial fiber, strain: coli ATCC11229, klebsiella pneumoniae ATCC 4352. The test results are shown in Table 1.

Table 1: composite antibacterial fiber bacteriostasis rate test meter (%)

	Escherichia coli ATCC11229	Klebsiella pneumoniae ATCC4352
			Example 1	50.2	66.8
Example 2	52.6	69.2
			Example 3	54.7	71.9
Example 4	54.1	94.5
			Example 5	58.7	98.8
Example 6	64.8	95.6

Claims

1. A composite antibacterial fiber is prepared from gallium nitrate, zinc oxide, gelatin, polyvinyl alcohol and water by conventional method.

2. The composite antibacterial fiber is prepared from 0.1-0.5 wt% of gallium nitrate, 0.5-2.0 wt% of zinc oxide, 2.0-3.0 wt% of gelatin, 10-20 wt% of polyvinyl alcohol and the balance of water by a conventional method.

3. The composite antibacterial fiber is prepared from 0.1-0.5 wt% of gallium nitrate, 0.5-1.5 wt% of 8-hydroxyquinoline copper, 0.5-2.0 wt% of zinc oxide, 2.0-3.0 wt% of gelatin, 10-20 wt% of polyvinyl alcohol and the balance of water by a conventional method.

4. A method for preparing the composite antibacterial fiber of any one of claims 1 to 2, characterized in that: heating water to 65-75 ℃, adding gelatin and polyvinyl alcohol, uniformly mixing, adding gallium nitrate and zinc oxide, uniformly stirring and mixing, standing and defoaming to obtain a spinning solution;

wet spinning, drafting, drying and heat setting.

5. A method for preparing the composite antibacterial fiber according to claim 3, which is characterized in that: heating water to 65-75 ℃, adding gelatin and polyvinyl alcohol, uniformly mixing, adding gallium nitrate, zinc oxide and 8-hydroxyquinoline copper, uniformly stirring and mixing, standing and defoaming to obtain a spinning stock solution;

wet spinning, drafting, drying and heat setting.