CN111718310A - 苯基取代的五元杂环类化合物及其制备方法、用途和药物组合物 - Google Patents
苯基取代的五元杂环类化合物及其制备方法、用途和药物组合物 Download PDFInfo
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- CN111718310A CN111718310A CN201910763655.7A CN201910763655A CN111718310A CN 111718310 A CN111718310 A CN 111718310A CN 201910763655 A CN201910763655 A CN 201910763655A CN 111718310 A CN111718310 A CN 111718310A
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
- C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/14—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
- C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
- C07D285/135—Nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
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Claims (9)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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CN201910763655.7A CN111718310B (zh) | 2019-08-19 | 2019-08-19 | 苯基取代的五元杂环类化合物及其制备方法、用途和药物组合物 |
PCT/CN2020/103850 WO2021031788A1 (zh) | 2019-08-19 | 2020-07-23 | 苯基取代的五元杂环类化合物及其制备方法、用途和药物组合物 |
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CN201910763655.7A CN111718310B (zh) | 2019-08-19 | 2019-08-19 | 苯基取代的五元杂环类化合物及其制备方法、用途和药物组合物 |
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CN111718310A true CN111718310A (zh) | 2020-09-29 |
CN111718310B CN111718310B (zh) | 2021-06-11 |
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WO (1) | WO2021031788A1 (zh) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112321513A (zh) * | 2020-11-06 | 2021-02-05 | 中国药科大学 | 杂环类化合物及其制备方法和用途 |
CN112479988A (zh) * | 2020-12-09 | 2021-03-12 | 中国药科大学 | 取代联苯类化合物及其制备方法、用途和药物组合物 |
CN113121464A (zh) * | 2021-04-21 | 2021-07-16 | 中国药科大学 | 五元杂环取代的联苯类化合物及其制备方法和用途 |
CN113248449A (zh) * | 2021-05-06 | 2021-08-13 | 中国药科大学 | 一种含甲脒的芳基螺环类化合物及其制备方法与应用 |
WO2023217276A1 (zh) * | 2022-05-13 | 2023-11-16 | 青岛清原化合物有限公司 | 一种杂环取代的芳香类化合物及其制备方法、除草组合物和应用 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0326601D0 (en) * | 2003-11-14 | 2003-12-17 | Novartis Ag | Organic compounds |
JP2012180281A (ja) * | 2009-06-29 | 2012-09-20 | Dainippon Sumitomo Pharma Co Ltd | 新規オキサジアゾール誘導体 |
EP2736904B1 (en) * | 2011-07-27 | 2016-03-16 | AB Science | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) |
CN103172627B (zh) * | 2011-12-26 | 2015-11-18 | 南京优科生物医药有限公司 | 杂环嘧啶苯或吡啶苯类化合物及其应用 |
AU2014316682B2 (en) * | 2013-09-06 | 2018-11-22 | Aurigene Discovery Technologies Limited | 1,2,4-oxadiazole derivatives as immunomodulators |
US9850225B2 (en) * | 2014-04-14 | 2017-12-26 | Bristol-Myers Squibb Company | Compounds useful as immunomodulators |
US10112935B2 (en) * | 2015-02-27 | 2018-10-30 | Lycera Corporation | Indazolyl thiadiazolamines and related compounds for inhibition of Rho-associated protein kinase and the treatment of disease |
US20170190689A1 (en) * | 2016-01-05 | 2017-07-06 | Incyte Corporation | Pyridine and pyridimine compounds as pi3k-gamma inhibitors |
AU2017294231B2 (en) * | 2016-07-05 | 2021-09-09 | Guangzhou Maxinovel Pharmaceuticals Co., Ltd | Aromatic acetylene or aromatic ethylene compound, intermediate, preparation method, pharmaceutical composition and use thereof |
CN106866571B (zh) * | 2017-01-20 | 2018-06-29 | 中国药科大学 | 杂环脲类化合物及其药物组合物和应用 |
GB201801226D0 (en) * | 2018-01-25 | 2018-03-14 | Redx Pharma Plc | Modulators of Rho-associated protein kinase |
WO2019156439A1 (en) * | 2018-02-07 | 2019-08-15 | Korea Research Institute Of Chemical Technology | Compounds for inhibiting tnik and medical uses thereof |
WO2019164996A1 (en) * | 2018-02-21 | 2019-08-29 | Southern Research Institute | 2-aminoaryl-5-aryloxazole analogs for the treatment of neurodegenerative diseases |
CN108530444B (zh) * | 2018-06-11 | 2021-08-24 | 药康众拓(江苏)医药科技有限公司 | 一种新型nampt和ido双重抑制剂及其制备方法和医药用途 |
CN109824621A (zh) * | 2019-03-28 | 2019-05-31 | 中国药科大学 | 噁二唑类和噻二唑类化合物及其制备方法和用途 |
CN109776445B (zh) * | 2019-03-28 | 2022-12-06 | 中国药科大学 | 苯并噁二唑类化合物及其制备方法和医药用途 |
-
2019
- 2019-08-19 CN CN201910763655.7A patent/CN111718310B/zh active Active
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2020
- 2020-07-23 WO PCT/CN2020/103850 patent/WO2021031788A1/zh active Application Filing
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112321513A (zh) * | 2020-11-06 | 2021-02-05 | 中国药科大学 | 杂环类化合物及其制备方法和用途 |
CN112479988A (zh) * | 2020-12-09 | 2021-03-12 | 中国药科大学 | 取代联苯类化合物及其制备方法、用途和药物组合物 |
CN112479988B (zh) * | 2020-12-09 | 2024-05-03 | 药康众拓(江苏)医药科技有限公司 | 取代联苯类化合物及其制备方法、用途和药物组合物 |
CN113121464A (zh) * | 2021-04-21 | 2021-07-16 | 中国药科大学 | 五元杂环取代的联苯类化合物及其制备方法和用途 |
CN113121464B (zh) * | 2021-04-21 | 2023-02-24 | 药康众拓(江苏)医药科技有限公司 | 五元杂环取代的联苯类化合物及其制备方法和用途 |
CN113248449A (zh) * | 2021-05-06 | 2021-08-13 | 中国药科大学 | 一种含甲脒的芳基螺环类化合物及其制备方法与应用 |
WO2023217276A1 (zh) * | 2022-05-13 | 2023-11-16 | 青岛清原化合物有限公司 | 一种杂环取代的芳香类化合物及其制备方法、除草组合物和应用 |
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WO2021031788A1 (zh) | 2021-02-25 |
CN111718310B (zh) | 2021-06-11 |
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Effective date of registration: 20210726 Address after: 100036 Beijing city Haidian District Cuiwei Road No. 2, building A, room 1209, static source in Patentee after: Beijing Kexiang Zhongsheng Pharmaceutical Technology Co.,Ltd. Address before: No. 639 road in Nanjing city in Jiangsu province 211198. Patentee before: CHINA PHARMACEUTICAL University |
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Effective date of registration: 20210804 Address after: 224500 4th floor, North building, building 2, enterprise accelerator, Xin'an Avenue, Binhai Pharmaceutical Industrial Park, Binhai County, Yancheng City, Jiangsu Province Patentee after: Yaokang Zhongtuo (Jiangsu) Pharmaceutical Technology Co.,Ltd. Address before: 100036 Beijing city Haidian District Cuiwei Road No. 2, building A, room 1209, static source in Patentee before: Beijing Kexiang Zhongsheng Pharmaceutical Technology Co.,Ltd. |
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Denomination of invention: Phenyl substituted five membered heterocyclic compounds and their preparation methods, uses and pharmaceutical compositions Effective date of registration: 20220926 Granted publication date: 20210611 Pledgee: China Construction Bank Corporation Binhai Sub branch Pledgor: Yaokang Zhongtuo (Jiangsu) Pharmaceutical Technology Co.,Ltd. Registration number: Y2022980016528 |