CN111714401A - 一种保湿原液及其制备和使用方法 - Google Patents
一种保湿原液及其制备和使用方法 Download PDFInfo
- Publication number
- CN111714401A CN111714401A CN201910209187.9A CN201910209187A CN111714401A CN 111714401 A CN111714401 A CN 111714401A CN 201910209187 A CN201910209187 A CN 201910209187A CN 111714401 A CN111714401 A CN 111714401A
- Authority
- CN
- China
- Prior art keywords
- moisturizing
- vitamin
- percent
- sodium hyaluronate
- stock solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 52
- 239000011550 stock solution Substances 0.000 title claims abstract description 40
- 238000000034 method Methods 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title description 6
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 39
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 39
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 30
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical group [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 claims abstract description 26
- 230000002087 whitening effect Effects 0.000 claims abstract description 24
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical group OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims abstract description 18
- 239000003963 antioxidant agent Substances 0.000 claims abstract description 17
- 230000003078 antioxidant effect Effects 0.000 claims abstract description 17
- 230000001153 anti-wrinkle effect Effects 0.000 claims abstract description 16
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 14
- 229940101267 panthenol Drugs 0.000 claims abstract description 14
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 14
- 239000011619 pantothenol Substances 0.000 claims abstract description 14
- 229910052943 magnesium sulfate Inorganic materials 0.000 claims abstract description 13
- 235000019341 magnesium sulphate Nutrition 0.000 claims abstract description 13
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229960003180 glutathione Drugs 0.000 claims abstract description 9
- 150000001413 amino acids Chemical group 0.000 claims abstract description 8
- 108010024636 Glutathione Proteins 0.000 claims abstract description 7
- GDBQQVLCIARPGH-UHFFFAOYSA-N Leupeptin Natural products CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(C=O)CCCN=C(N)N GDBQQVLCIARPGH-UHFFFAOYSA-N 0.000 claims abstract description 7
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 7
- GDBQQVLCIARPGH-ULQDDVLXSA-N leupeptin Chemical group CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C=O)CCCN=C(N)N GDBQQVLCIARPGH-ULQDDVLXSA-N 0.000 claims abstract description 7
- 108010052968 leupeptin Proteins 0.000 claims abstract description 7
- 229940088594 vitamin Drugs 0.000 claims abstract description 7
- 229930003231 vitamin Natural products 0.000 claims abstract description 7
- 235000013343 vitamin Nutrition 0.000 claims abstract description 7
- 239000011782 vitamin Substances 0.000 claims abstract description 7
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 6
- 235000010755 mineral Nutrition 0.000 claims abstract description 6
- 239000011707 mineral Substances 0.000 claims abstract description 6
- 239000002994 raw material Substances 0.000 claims abstract description 6
- 235000006708 antioxidants Nutrition 0.000 claims abstract description 4
- 235000005152 nicotinamide Nutrition 0.000 claims abstract description 4
- 239000011570 nicotinamide Substances 0.000 claims abstract description 4
- 229960003966 nicotinamide Drugs 0.000 claims abstract description 4
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 4
- 239000000306 component Substances 0.000 claims abstract 19
- 239000011259 mixed solution Substances 0.000 claims description 31
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims description 28
- 235000001014 amino acid Nutrition 0.000 claims description 18
- 229940024606 amino acid Drugs 0.000 claims description 18
- 238000003756 stirring Methods 0.000 claims description 16
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims description 14
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims description 14
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 14
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 11
- -1 compound amino acid Chemical class 0.000 claims description 11
- 238000001816 cooling Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 9
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 7
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 7
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 7
- 229930003779 Vitamin B12 Natural products 0.000 claims description 7
- 229930003756 Vitamin B7 Natural products 0.000 claims description 7
- 229930003761 Vitamin B9 Natural products 0.000 claims description 7
- 238000006243 chemical reaction Methods 0.000 claims description 7
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 7
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 7
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 7
- 235000019163 vitamin B12 Nutrition 0.000 claims description 7
- 239000011715 vitamin B12 Substances 0.000 claims description 7
- 239000011726 vitamin B6 Substances 0.000 claims description 7
- 235000019158 vitamin B6 Nutrition 0.000 claims description 7
- 235000011912 vitamin B7 Nutrition 0.000 claims description 7
- 239000011735 vitamin B7 Substances 0.000 claims description 7
- 235000019159 vitamin B9 Nutrition 0.000 claims description 7
- 239000011727 vitamin B9 Substances 0.000 claims description 7
- 229940011671 vitamin b6 Drugs 0.000 claims description 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
- 239000006210 lotion Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- 239000004471 Glycine Substances 0.000 claims description 3
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 3
- 235000018417 cysteine Nutrition 0.000 claims description 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 3
- 229920002674 hyaluronan Polymers 0.000 claims description 3
- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 2
- 239000004475 Arginine Substances 0.000 claims description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- 241001085205 Prenanthella exigua Species 0.000 claims description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004473 Threonine Substances 0.000 claims description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 2
- 235000004279 alanine Nutrition 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 235000003704 aspartic acid Nutrition 0.000 claims description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 2
- 229960000310 isoleucine Drugs 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 2
- 150000003384 small molecules Chemical group 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 239000004474 valine Substances 0.000 claims description 2
- 235000019156 vitamin B Nutrition 0.000 claims description 2
- 239000011720 vitamin B Substances 0.000 claims description 2
- 238000005282 brightening Methods 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 3
- 239000002932 luster Substances 0.000 abstract description 2
- 230000037394 skin elasticity Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 54
- 230000000694 effects Effects 0.000 description 17
- 230000037303 wrinkles Effects 0.000 description 15
- 238000012360 testing method Methods 0.000 description 14
- 239000008367 deionised water Substances 0.000 description 13
- 229910021641 deionized water Inorganic materials 0.000 description 13
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 12
- 239000000047 product Substances 0.000 description 11
- 235000015097 nutrients Nutrition 0.000 description 7
- 239000002537 cosmetic Substances 0.000 description 6
- 230000014759 maintenance of location Effects 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 230000036564 melanin content Effects 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 208000012641 Pigmentation disease Diseases 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000001804 emulsifying effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000019612 pigmentation Effects 0.000 description 3
- WZHKXNSOCOQYQX-FUAFALNISA-N (2s)-6-amino-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-amino-3-(1h-imidazol-5-yl)propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide Chemical compound C([C@H](N)C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CN=CN1 WZHKXNSOCOQYQX-FUAFALNISA-N 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 210000001061 forehead Anatomy 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000012466 permeate Substances 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108010038807 Oligopeptides Proteins 0.000 description 1
- 102000015636 Oligopeptides Human genes 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 235000014666 liquid concentrate Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000002780 melanosome Anatomy 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000001126 phototherapy Methods 0.000 description 1
- 210000004694 pigment cell Anatomy 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 230000036555 skin type Effects 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 238000004383 yellowing Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
- A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
本发明提供一种保湿原液，按照重量百分比，用于制备所述保湿原液的原料包含：抗皱成分、美白成分、保湿成分、抗氧化剂、维生素、矿物质成分和水；所述抗皱成分选自氨基酸和透明质酸钠；所述美白成分选自亮白六肽和烟酰胺；所述保湿成分选自透明质酸钠和泛醇；所述抗氧化剂选自谷胱甘肽和对羟基苯乙酮，所述矿物质成分选自硫酸镁。本发明提供的保湿原液配方、工艺和使用方法，安全有效，在保湿、抗皱、美白、亮肤和保持肌肤弹性有光泽方面具有突出的实质性特点和显著的技术进步。
Description
技术领域
本发明涉及一种化妆品技术领域，具体涉及一种具有抗皱和美白功效的保湿原液、制备及其使用方法。
背景技术
原液一词最早来源工业制造中，用于描述某种浓缩液体的母体。在被引入化妆品行业后，专门指代一种护肤品类。化妆品行业中的原液，指的是添加相对单一的高浓度护肤成分，能够针对各种肌肤需要，给肌肤更直接、更安全和更强效的保养，让肌肤在短时间内恢复最佳状态的美容产品。
化妆品市场的水乳和精华原液具有清爽滋润的效果，但常常效果较为单一，一般只注重补水、保湿，部分产品会略有美白和紧致肌肤的辅助功效；霜类的护肤功能较为多样化，但其肤感较为黏腻，使用范围受限于地区气候与人群肤质。由于皮肤角质层的屏障作用，大分子营养物质难以渗入皮肤，使用促渗剂法才能使部分500＜Ｍr＜1000的物质渗入皮肤。中华医学会皮肤性病学分会皮肤激光医疗美容学组和中国医师协会美容与整形医师分会激光亚专委会（电子注射（水光疗法）专家共识[J]. 实用皮肤病学杂志，2018，11（2）：65-66.）提到广受欢迎的水光针虽然可以通过针剂进入真皮层，但存在疼痛感强、色斑沉着、过敏和感染等安全问题，并且因价格昂贵等原因未能满足大部分消费者需要。
发明内容
本发明的目的是为了解决现有技术的营养成分少和皮肤难吸收的问题，提供了一种抗皱和美白功效明显的保湿原液。结合微针的导入促进大分子营养物质的吸收，使皮肤亮白有光泽，去除细小皱纹，使有弹性。
为实现本发明的目的，一方面，本发明提供一种保湿原液，所述保湿原液包括抗皱成分、美白成分、保湿成分、抗氧化剂、维生素、矿物质成分和水；所述抗皱成分选自氨基酸和透明质酸钠；所述美白成分选自亮白六肽和烟酰胺；所述保湿成分选自透明质酸钠、水解透明质酸钠和泛醇；所述抗氧化剂选自谷胱甘肽和对羟基苯乙酮，所述矿物质成分选自硫酸镁。
1. 优选地，所述保湿原液包含以下重量百分比计的成分：透明质酸钠0.3%－1.0%，水解透明质酸钠0.2%－1.0%，γ-氨基丁酸0.1%－0.8%，亮白六肽0.5%－3.0%，烟酰胺1.0－5.0%，复合氨基酸1.0%－5.0%，泛醇0.1%－3.0%，硫酸镁0.01%-0.05%，抗氧化剂0.1%－0.8%，维生素0.1%-1.0%，去离子水水85.0%-91.0%。
优选地，所述复合氨基酸选自赖氨酸、缬氨酸、精氨酸、蛋氨酸、天冬氨酸、异亮氨酸、苏氨酸、亮氨酸、丝氨酸、酪氨酸、谷氨酰胺、苯丙氨酸、脯氨酸、组氨酸、甘氨酸、半胱氨酸、丙氨酸中的一种或多种。
优选地，所述透明质酸钠为小分子透明质酸钠，其分子量范围在1.5-3万。
优选地，所述维生素选自水溶性的B族维生素，所述水溶性的B族维生素选自维生素B6、维生素B7、维生素B9和维生素B12中的一种或多种。
优选地，所述谷胱甘肽和对羟基苯乙酮的添加比例为1:3。
另一方面，本发明提供一种如上所述的保湿原液的制备方法，包括以下步骤：
步骤1，将水、透明质酸钠、水解透明质酸和泛醇加入反应容器中，升温至70℃-85℃搅拌使各组分溶解至透明，保温20-30分钟，降温，获得第一混合液；
步骤2，将维生素B6、维生素B7、维生素B12、烟酰胺、抗氧化剂、硫酸镁、γ-氨基丁酸加入45℃-50℃的水中，混合搅拌均匀后，投入步骤1中的反应容器中，与所述第一混合液混合，获得第二混合液；
步骤3，将维生素B9用水溶解后，加入所述第二混合液，搅拌均匀，降温到30℃-35℃，获得第三混合液；
步骤4，将亮白六肽和复合氨基酸加入所述第三混合液中，搅拌均匀，获得所述保湿原液。
在本发明另一方面，本发明还提供了一种如上所述的保湿原液的使用方法，包括将所述保湿原液通过微针导入皮肤。
本发明中上述中透明质酸钠和水解透明质酸钠在微针导入的辅助下透入皮肤表层直接到达真皮层，水解透明质酸钠可扩张毛细血管、增加血液微循环，改善皮肤新陈代谢，赋予肌肤弹性等特性；同时透明质酸钠是线性多糖透明质酸的钠盐形式，是人体皮肤基质的构成之一，存在于结缔组织的基质中，具有良好的锁水和保湿效果。
本发明中上述亮白六肽成分有六肽-2、丁二醇和水。六肽-2为含有六个氨基酸的美容多肽，可刺激胶原蛋白合成，使肌肤变得均匀有活力，是一种有效的亮白寡肽，其主要用于美白亮肤及祛斑产品。
本发明中上述γ-氨基丁酸（GABA），是广泛分布于动植物体内的一种非蛋白质氨基酸。GABA有抗衰老的功效，可减少皮肤细纹和皱纹，促进透明质酸钠和胶原蛋白合成以及光滑肌肤、改善肤色等作用。
本发明中上述烟酰胺，具有很高的安全性，能极大减少皮肤老化现象，比如色素沉着、发黄、毛孔粗大等。抑制黑素小体从色素细胞转移到角质形成细胞，抑制黑素输送途径，减少面部红斑、色素沉积；阻止蛋白质非酶糖化，改善面部发黄的状况；通过减少油脂的分泌，减小毛孔使皮肤纹理细腻光滑。
本发明中上述谷胱甘肽（GSH）由谷氨酸、半胱氨酸和甘氨酸组合成，三种氨基酸均为含有巯基（-SH）的三肽，不仅能消除人体自由基，还可以提高人体免疫力。其广谱的抗氧化能力能抑制皮肤褐变，有效调理肌肤。
本发明中上述对羟基苯乙酮，分子活性弱、耐高温，能够延长其它有效成分的保质期，对人皮肤无害，是目前医药界较为安全的高温辅助活性稳定剂。
针对现有产品营养成分少和难吸收的问题，本发明提供的集补水保湿、抗皱紧致、美白亮颜等多种功效的原液，利用微针导入的优势，微针刺入皮肤后可在角质层形成多个通道，这些通道允许大分子营养物（Ｍr＞10000）通过，且不破坏皮肤结构的完整性。利用透明质酸钠和水解透明质酸钠的强渗透性，促进肌肤对功能性营养成分的快速吸收，起到“微注射”的效果。一般在进行微针导入治疗后，皮肤会处于缺水状态，但该原液具有多种强而有效的保湿成分，在皮肤进行微针后，可有效帮助皮肤补水和保湿。同时该配方未添加任何防腐剂和香精，安全度高。
总之，本发明提供的具有抗皱和美白功效的保湿原液配方、工艺和使用方法，安全有效，在保湿、抗皱、美白、亮肤和保持肌肤弹性有光泽方面具有突出的实质性特点和显著的技术进步。
附图说明
图1为本发明实施例一中的保湿原液保湿性测试效果对比图；
图2为本发明实施例二中的保湿原液的美白性测试效果对比图；
图3为本发明实施例三中的保湿原液的抗皱性测试效果对比图。
具体实施方式
为进一步阐述本发明达成预定目的所采取的技术手段及功效，以下结合附图及实施例对本发明的具体实施方式、技术特征及其功效，详细说明如下。
实施例一
本实施例提供一种保湿原液，按照重量百分比，用于制备所述保湿原液的原料包含：透明质酸钠0.8%，水解透明质酸钠0.5%，0.4%泛醇，γ-氨基丁酸0.3%，亮白六肽2.0%，烟酰胺3.0%，复合氨基酸4.0%，硫酸镁0.02%，抗氧化剂0.35%，多种维生素0.133%，去离子水88.497%。
本实施例还公开了上述保湿原液的制备工艺，具体包括以下步骤：
步骤1，将61.95%去离子水、0.8%的透明质酸钠、0.5%水解透明质酸钠和0.4%泛醇先加入乳化锅，升温至80℃搅拌使各组分溶解至透明，保温20分钟，降温至45℃，获得第一混合液；
步骤2，将0.12%维生素B6、0.01%维生素B7、0.001%维生素B12、3.0%烟酰胺、0.35%抗氧化剂、0.02%硫酸镁、0.3%γ-氨基丁酸加入45℃的17.70%去离子水中，混合搅拌均匀后，投入步骤1中的反应容器中，与所述第一混合液混合，获得第二混合液；
步骤3，将0.002%维生素B9用45℃的8.847%去离子水溶解后加入前面步骤2与步骤1的混合液，降温到30℃，获得第三混合液；
步骤4，将2.0%亮白六肽和4.0%复合氨基酸加入第三混合液中，搅拌均匀，获得所述保湿原液。
实施例二
本实施例提供一种保湿原液，按照重量百分比，用于制备所述保湿原液的原料包含：透明质酸钠0.8%，水解透明质酸钠0.5%，0.4%泛醇，γ-氨基丁酸0.35%，亮白六肽2.5%，烟酰胺5.0%，复合氨基酸3.0%，硫酸镁0.02%，抗氧化剂0.35%，多种维生素0.133%，去离子水86.947%。
在本实施例还公开了上述保湿原液的制备工艺，具体包括以下步骤：
步骤1，将60.86%去离子水、0.8%透明质酸钠、0.5%水解透明质酸钠和0.4%泛醇先加入乳化锅，升温至85℃搅拌使各组分溶解至透明，保温20分钟，降温至50℃，获得第一混合液；
步骤2，将0.12%维生素B6、0.01%维生素B7、0.001%维生素B12、5.0%烟酰胺、0.35%抗氧化剂、0.02%硫酸镁、0.35%γ-氨基丁酸加入50℃的17.39%去离子水中，混合搅拌均匀后，投入步骤1中的反应容器中，与第一混合液混合，获得第二混合液；
步骤3，将0.002%维生素B9用45℃的8.697%去离子水溶解后加入所述第二混合液，降温至35℃，获得第三混合液；
步骤4，将2.5%亮白六肽和3.0%复合氨基酸加入第三混合液中，搅拌均匀，获得所述保湿原液。
实施例三
本实施例提供一种保湿原液，按照重量百分比，用于制备所述保湿原液的原料包含：透明质酸钠0.8%，水解透明质酸钠0.7%，0.4%泛醇，γ-氨基丁酸0.5%，亮白六肽2.5%，烟酰胺3.0%，复合氨基酸4.0%，硫酸镁0.02%，抗氧化剂0.35%，多种维生素0.133%，去离子水87.597%。
在本实施例还公开了上述保湿原液的制备工艺，具体包括以下步骤：
步骤1，将61.32%去离子水、0.8%透明质酸钠、0.7%水解透明质酸钠和0.4%泛醇先加入乳化锅，升温至75℃搅拌使各组分溶解至透明，保温30分钟，降温至45℃，获得第一混合液；
步骤2，将0.12%维生素B6、0.01%维生素B7、0.001%维生素B12、3.0%烟酰胺、0.35%抗氧化剂、0.02%硫酸镁、0.5%γ-氨基丁酸用45℃的17.52%去离子溶解后，投入步骤1中的反应容器中，与第一混合液混合，获得第二混合液，
步骤3，将0.002%维生素B9用45℃的8.757%去离子水溶解后，加入所述第一混合液和第二混合液，降温到35℃，获得第三混合液。
步骤4，将2.5%亮白六肽和4.0%复合氨基酸加入上述混合溶液中，搅拌均匀，获得所述保湿原液。
下面通过实验来说明本发明保湿原液的保湿、美白和抗皱效果：
一、保湿性测定
测试原理：使用人体皮肤测试仪（TM-3688），通过测试志愿者使用产品前后，皮肤含水量的变化来评估产品的保湿能力。
选取15位志愿者，年龄在30-35岁之间，在两手臂内侧固定的区域使用相同量的实施例一中获取的原液，用量均为2mg/cm2，利用人体皮肤测试仪来测试志愿者使用前后的皮肤水分含量（%），并取平均值，评估产品的保湿性能。水分含量测试结果如下表1所示，同时给出保湿性能的测试效果，见表1和图1。
表1 皮肤水分含量数据记录
从表1和图1中可以看出，使用实施例一中的保湿原液可以明显增加皮肤水分，从而增加皮肤保湿能力，使肌肤处于一个水分充足的健康状态。
二、美白性（皮肤黑色素含量）测定
测试原理：使用德国CK皮肤水份测试仪（TM300），通过测试志愿者使用产品前后皮肤黑色素含量（MI值）的变化来评估产品的美白功效。
实验方法：选取15位志愿者，年龄在30-35岁之间，在脸部使用相同用量的实施例二中的原液，用量3ml，一次微针导入后，测试志愿者皮肤黑色素含量，取其平均值评估产品的美白功效。测试结果见下表2。
表2实施例二中原液的美白效果（黑色素含量）记录表
| 部位 | 额头（%） | 左侧脸颊（%） | 右侧脸颊（%） | 下巴（%） |
| 初始值 | 19.3 | 19.7 | 19.7 | 23.7 |
| 结束值 | 16 | 17.7 | 16.7 | 22 |
| 变化值 | -2.7 | -2 | -3 | -1.7 |
备注：美白性测试指标以黑色素数值（MI值）为指标，数值越大，表示黑色素越多；反之数值越小，表示黑色素越少。变化值（结束值-开始值）为负值，表示具有美白效果。
从表2以及图2可以看出，一次微针导入实施例二中的原液后，皮肤黑色素减少，有一定亮白肤色效果。
三、抗皱性测试
测试原理：使用VISIA皮肤检测仪，通过志愿者一次微针前后的皱纹百分比数值变化来评估原液的抗皱性。
实验方法：选取15位志愿者，年龄在30-35岁之间，在脸部使用相同用量的实施例三中的原液，用量5ml，一次微针导入后，使用VISIA测试志愿者皱纹指标百分比（%），评估产品的抗皱功效。皱纹百分比是通过对个人的绝对评分与相同性别、年龄和皮肤类型的人群进行比较的结果。百分比使用庞大的原有数据库，让志愿者了解他们的皮肤与同组的人员对比情况。测试结果见下表3和图3。
表3 实施例三中原液的抗皱效果记录表
| 部位 | 前视图（%） | 右视图（%） | 左视图（%） |
| 初始值 | 57 | 64 | 47 |
| 结束值 | 79 | 79 | 57 |
| 变化值 | 22 | 15 | 10 |
备注：皱纹指标以百分比数值为指标，数值越大，表示在同组中排名靠前，即表示皱纹越少；反之，数值越小，表示在同组中排名靠后，即表示皱纹越多。变化值（结束值-开始值）为正值，表示皱纹减少。
从表3以及图3可以看出，一次微针导入实施例3中的原液后，额头和左右眼处皱纹明显减少，祛除皱纹效果明显。
综上所述，本发明采用透明质酸钠和泛醇等保湿成分，长效保持皮肤表面水润光滑；亮白六肽和烟酰胺等美白成分，有效抑制黑色素生成，降低皮肤黑色素含量，提亮肤色。γ-氨基丁酸和复合氨基酸等抗皱成分，有效加快皮肤新陈代谢，促进皮肤光滑，延缓皮肤老化，达到减少皱纹的效果；同时借助微针导入的优势促进各组分营养物质的吸收。
以上所述仅为本发明的实施例，并非因此限制本发明的专利范围，凡是利用本发明说明书内容所作的等效工艺或等效流程变换，直接或间接运用在其他相关的技术领域，均同理包括在本发明的专利保护范围内。
Claims (8)
1.一种保湿原液，其特征在于，按照重量百分比，用于制备所述保湿原液的原料包含：抗皱成分、美白成分、保湿成分、抗氧化剂、维生素、矿物质成分和水；所述抗皱成分选自氨基酸和透明质酸钠；所述美白成分选自亮白六肽和烟酰胺；所述保湿成分选自透明质酸钠、水解透明质酸钠和泛醇；所述抗氧化剂选自谷胱甘肽和对羟基苯乙酮，所述矿物质成分选自硫酸镁。
2.根据权利要求1所述的保湿原液，其特征在于，所述原料包含以下重量百分比的成分：透明质酸钠0.3%－1.0%，水解透明质酸钠0.2%－1.0%，γ-氨基丁酸0.1%－0.8%，亮白六肽0.5%－3.0%，烟酰胺1.0－5.0%，复合氨基酸1.0%－5.0%，泛醇0.1%－3.0%，硫酸镁0.01%-0.05%，抗氧化剂0.1%－0.8%，维生素0.1%-1.0%，水85.0%-91.0%。
3.根据权利要求1所述的保湿原液，其特征在于，所述复合氨基酸选自赖氨酸、缬氨酸、精氨酸、蛋氨酸、天冬氨酸、异亮氨酸、苏氨酸、亮氨酸、丝氨酸、酪氨酸、谷氨酰胺、苯丙氨酸、脯氨酸、组氨酸、甘氨酸、半胱氨酸、丙氨酸中的一种或多种。
4.根据权利要求1所述的保湿原液，其特征在于，所述透明质酸钠为小分子透明质酸钠，其分子量范围在1.5-3万。
5.根据权利要求1所述的保湿原液，其特征在于，所述维生素选自水溶性的B族维生素，所述水溶性的B族维生素选自维生素B6、维生素B7、维生素B9和维生素B12中的一种或多种。
6.根据权利要求1所述的保湿原液，其特征在于，所述谷胱甘肽和对羟基苯乙酮的添加比例为1:3。
7.一种如权利要求1所述的保湿原液的制备方法，其特征在于，包括以下步骤：
步骤1，将水、透明质酸钠、水解透明质酸和泛醇加入反应容器中，升温至70℃-85℃搅拌使各组分溶解至透明，保温20-30分钟，降温，获得第一混合液；
步骤2，将维生素B6、维生素B7、维生素B12、烟酰胺、抗氧化剂、硫酸镁、γ-氨基丁酸加入45℃-50℃的水中，混合搅拌均匀后，投入步骤1中的反应容器中，与所述第一混合液混合，获得第二混合液；
步骤3，将维生素B9用水溶解后，加入所述第二混合液，搅拌均匀，降温到30℃-35℃，获得第三混合液；
步骤4，将亮白六肽和复合氨基酸加入所述第三混合液中，搅拌均匀，获得所述保湿原液。
8.一种如权利要求1-6任一项所述的保湿原液的使用方法，其特征在于，所述保湿原液是通过微针导入皮肤的。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910209187.9A CN111714401A (zh) | 2019-03-19 | 2019-03-19 | 一种保湿原液及其制备和使用方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910209187.9A CN111714401A (zh) | 2019-03-19 | 2019-03-19 | 一种保湿原液及其制备和使用方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111714401A true CN111714401A (zh) | 2020-09-29 |
Family
ID=72562492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910209187.9A Pending CN111714401A (zh) | 2019-03-19 | 2019-03-19 | 一种保湿原液及其制备和使用方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111714401A (zh) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107440957A (zh) * | 2017-08-14 | 2017-12-08 | 泉州亚林新材料科技有限公司 | 一种壳聚糖精华液 |
| CN107951742A (zh) * | 2017-12-28 | 2018-04-24 | 娇时日化（杭州）股份有限公司 | 一种玻尿酸抗皱原液 |
| CN109453105A (zh) * | 2018-12-26 | 2019-03-12 | 广州蜜妆生物科技有限公司 | 一种保湿亮肤精华液及其制备方法 |
-
2019
- 2019-03-19 CN CN201910209187.9A patent/CN111714401A/zh active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107440957A (zh) * | 2017-08-14 | 2017-12-08 | 泉州亚林新材料科技有限公司 | 一种壳聚糖精华液 |
| CN107951742A (zh) * | 2017-12-28 | 2018-04-24 | 娇时日化（杭州）股份有限公司 | 一种玻尿酸抗皱原液 |
| CN109453105A (zh) * | 2018-12-26 | 2019-03-12 | 广州蜜妆生物科技有限公司 | 一种保湿亮肤精华液及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US11234921B2 (en) | Moisturizing compositions and uses thereof | |
| CN106265348B (zh) | 一种具有修护皮肤屏障和抗衰老功效的基质及其制备方法和应用 | |
| CN104010662B (zh) | 使皮肤回春的组合物和方法 | |
| CN113576975B (zh) | 一种易吸收的抗衰老组合物及其制备方法和应用 | |
| CN110664644B (zh) | 一种含叶酸的护肤组合物、精华及其制备方法 | |
| Zasada et al. | Preliminary randomized controlled trial of antiaging effects of l‐ascorbic acid applied in combination with no‐needle and microneedle mesotherapy | |
| CN109730954A (zh) | 具有镇敏、舒缓、修护、改善皮脂膜作用的护肤品及其制备方法 | |
| ES2856480T3 (es) | Utilizaciones cosméticas de la swertiamarina | |
| US12059486B2 (en) | Cosmetic compositions | |
| CN112656713A (zh) | 一种含透明质酸和/或其衍生物的美容组合物及其制备方法和用途 | |
| CN113768853B (zh) | 一种美白淡斑组合物及其制备方法和应用 | |
| CN111991336B (zh) | 一种多效凝胶精华及其制备方法与应用 | |
| US20190298688A1 (en) | Putrescine slow-release topical formulations | |
| CN115040464A (zh) | 一种具有祛皱抗衰作用的精华液组合及其制备方法 | |
| CN108113920B (zh) | 一种缓释美白复合保湿面霜基质及其制备方法和应用 | |
| CN113952277A (zh) | 一种微晶肽抗皱面霜及其制备方法 | |
| KR20090054777A (ko) | 피부의 ｐΗ 조절용 조성물 및 이를 포함하는 화장품 | |
| CN111557872A (zh) | 一种多元寡肽组合物护肤品 | |
| CN113081942A (zh) | 一种含有苹果干细胞的多维水合霜 | |
| CN112870108A (zh) | 一种具有抗衰老、保湿功效的组合物及其制备方法和应用 | |
| CN111714401A (zh) | 一种保湿原液及其制备和使用方法 | |
| CN105496822A (zh) | 果酸护肤液及其制备方法 | |
| KR20070022170A (ko) | 효소 및 아미노산을 함유하는 피부 화장료 조성물 | |
| CN107802516A (zh) | 一种长效保湿护肤精华液 | |
| CN114533584B (zh) | 一种胶原蛋白酶抗皱面霜 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200929 |