CN111712255A - 用抗pd-1抗体治疗癌症的方法 - Google Patents

用抗pd-1抗体治疗癌症的方法 Download PDF

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Publication number
CN111712255A
CN111712255A CN201980013286.8A CN201980013286A CN111712255A CN 111712255 A CN111712255 A CN 111712255A CN 201980013286 A CN201980013286 A CN 201980013286A CN 111712255 A CN111712255 A CN 111712255A
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cancer
patient
antibody
seq
antigen
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Chinese (zh)
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M·拉拉
L·贾因
李梦瑶
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Merck Sharp and Dohme BV
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Merck Sharp and Dohme LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
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    • C—CHEMISTRY; METALLURGY
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201980013286.8A 2018-02-13 2019-02-08 用抗pd-1抗体治疗癌症的方法 Pending CN111712255A (zh)

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US201862630038P 2018-02-13 2018-02-13
US62/630038 2018-02-13
US201862732828P 2018-09-18 2018-09-18
US62/732828 2018-09-18
PCT/US2019/017177 WO2019160751A2 (en) 2018-02-13 2019-02-08 Methods for treating cancer with anti-pd-1 antibodies

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US (2) US12358984B2 (https=)
EP (1) EP3752180A4 (https=)
JP (2) JP2021513541A (https=)
KR (1) KR20200119844A (https=)
CN (2) CN111712255A (https=)
AU (2) AU2019220495B2 (https=)
BR (1) BR112020016331A8 (https=)
CA (1) CA3090995A1 (https=)
CL (1) CL2020002075A1 (https=)
IL (1) IL276303A (https=)
MA (1) MA52789A (https=)
MX (2) MX2020008445A (https=)
SG (1) SG11202007590TA (https=)
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CN112326961A (zh) * 2020-10-30 2021-02-05 福州迈新生物技术开发有限公司 一种非小细胞肺癌中pd-l1阳性肿瘤细胞比例的分析方法和存储设备
CN112394102A (zh) * 2020-11-05 2021-02-23 上海交通大学医学院附属瑞金医院 一种检测垂体功能减退症的标志物及其应用
CN113893343A (zh) * 2021-10-16 2022-01-07 广州誉衡生物科技有限公司 抗-pd-1抗体及其在制备治疗宫颈癌患者的药物中的用途

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BR122017025062B8 (pt) 2007-06-18 2021-07-27 Merck Sharp & Dohme anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento
KR102650991B1 (ko) 2019-03-25 2024-03-27 (주)알테오젠 인간 히알루로니다제 ph20의 변이체와 약물을 포함하는 피하투여용 약학 조성물
US20220380469A1 (en) * 2019-09-27 2022-12-01 Merck Sharp & Dohme Corp. Methods for treating metastatic triple negative breast cancer with anti-pd-1 antibodies
SI4076385T1 (sl) 2019-12-20 2026-04-30 Formycon Ag Formulacije protiteles anti-pd1
US20230050449A1 (en) * 2019-12-20 2023-02-16 Merck Sharp & Dohme Llc Methods for treating cancer using a combination of a pd-1 antagonist, an ilt4 antagonist, and chemotherapeutic agents
JP2024527517A (ja) 2021-06-23 2024-07-25 フォーマイコン アーゲー 抗ｐｄ１抗体製剤
US20250011453A1 (en) * 2021-07-20 2025-01-09 Merck Sharp & Dohme Llc Methods for treating cancer using a combination of a pd-1 antagonist, an ilt4 antagonist, and chemotherapeutic agents
US20250044295A1 (en) * 2021-12-16 2025-02-06 Merck Sharp & Dohme Llc Biomarkers for predicting eligibility for an anti-ilt4 and anti-pd-1 combination therapy
EP4637818A1 (en) 2022-12-21 2025-10-29 Formycon AG Formulations of anti-pd1 antibodies
CN115925954A (zh) * 2022-12-28 2023-04-07 广州誉衡生物科技有限公司 抗-pd-1抗体及其在制备治疗尿路上皮癌患者的药物中的用途
WO2025140467A1 (zh) * 2023-12-29 2025-07-03 上海复宏汉霖生物技术股份有限公司 稳定的高浓度抗pd-1抗体药物制剂

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112326961A (zh) * 2020-10-30 2021-02-05 福州迈新生物技术开发有限公司 一种非小细胞肺癌中pd-l1阳性肿瘤细胞比例的分析方法和存储设备
CN112394102A (zh) * 2020-11-05 2021-02-23 上海交通大学医学院附属瑞金医院 一种检测垂体功能减退症的标志物及其应用
CN112394102B (zh) * 2020-11-05 2023-05-26 上海交通大学医学院附属瑞金医院 一种检测垂体功能减退症的标志物及其应用
CN113893343A (zh) * 2021-10-16 2022-01-07 广州誉衡生物科技有限公司 抗-pd-1抗体及其在制备治疗宫颈癌患者的药物中的用途

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BR112020016331A2 (pt) 2020-12-15
CN120919306A (zh) 2025-11-11
WO2019160751A2 (en) 2019-08-22
JP2021513541A (ja) 2021-05-27
EP3752180A2 (en) 2020-12-23
CL2020002075A1 (es) 2020-10-23
AU2026201041A1 (en) 2026-03-05
US12358984B2 (en) 2025-07-15
BR112020016331A8 (pt) 2023-02-07
RU2020129827A (ru) 2022-03-14
MA52789A (fr) 2021-04-14
MX2020008445A (es) 2020-09-28
MX2024013016A (es) 2024-11-08
IL276303A (en) 2020-09-30
EP3752180A4 (en) 2021-12-15
JP2024038251A (ja) 2024-03-19
US20240026003A1 (en) 2024-01-25
AU2019220495A1 (en) 2020-08-13
US20210047408A1 (en) 2021-02-18
WO2019160751A3 (en) 2020-09-10
CA3090995A1 (en) 2019-08-22
KR20200119844A (ko) 2020-10-20
AU2019220495B2 (en) 2025-11-13
SG11202007590TA (en) 2020-09-29

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