CN111700959A - A topical medicinal patch prepared from a Chinese medicinal composition for treating constipation - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating constipation and an external medicinal plaster, which belong to the traditional Chinese medicine composition external medicinal plaster for treating constipation, which is stuck on a Shenque point. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw materials and components according to a mixing ratio, 5-30 g of raw rhubarb, 10-15 g of mirabilite, 2 g of peach kernel, 2 g of immature bitter orange, 2 g of magnolia officinalis, 1 g of areca nut, 1 g of white gourd seed, 1 g of cortex moutan, 1-5 g of cimicifuga foetida and 5-10 g of liquorice. All the traditional Chinese medicine raw materials are mixed and crushed into micro powder with 200-400 mesh sieve, the micro powder is sterilized and evenly mixed with dimethyl sulfoxide and vaseline to form a pasty medicine state, and the traditional Chinese medicine composition comprises the following components in parts by weight: dimethyl sulfoxide: petrolatum =1:1: 1; each external plaster is prepared by taking 3 g of the pasty medicine, putting the pasty medicine into an external medicine applying adhesive plaster, sterilizing and packaging. The stomach-regulating qi-supporting decoction is mainly used for treating heat syndrome of stomach intestine dryness of yangming, purging heat to relax bowels, washing intestines and stomach, removing heat by purging, softening hard masses to moisten dryness, tonifying qi, tonifying spleen and relieving pain, is used for treating constipation accompanied by abdominal fullness and pain, and is used for reinforcing qi and tonifying spleen, and treating the symptoms of intestinal warmth and moistening and driving weakness.

Description

A topical medicinal patch prepared from a Chinese medicinal composition for treating constipation

Technical Field

The invention belongs to a traditional Chinese medicine composition for treating constipation, in particular to an external plaster of the traditional Chinese medicine composition for treating the constipation, which is stuck on a Shenque point.

Background

Constipation is a functional intestinal disease which is characterized by difficult defecation for a long time, namely one defecation in 3-4 days or more than 3-4 days, incomplete defecation, dry and hard defecation and difficult defecation, and the disease is a common clinical disease and frequently encountered disease and affects the work, study and life of patients. The retention time of the excrement in the intestinal tract is too long, the putrefactive substances generated by putrefactive bacteria easily induce colon cancer in the intestinal tract, the colon cancer has great harm to the health of human bodies, the chronic disease affects the physical and mental health of patients for a long time, the patients are easy to be irritated and excited, the mood is depressed, and the accompanying symptoms such as obesity, anal fissure, dyspepsia and the like are easily caused. Constipation is closely related to the function of spleen and stomach, the spleen governs transportation and transformation, the stomach governs accepting, the spleen raises clear, the stomach lowers turbid, the function of spleen and stomach supplement each other and are the pivot of qi movement lifting, meanwhile, the functions of six fu organs are used for dredging, the stomach is used for dredging, and the stomach dredging function comprises the functional activities of food residues in small intestine to large intestine and dregs in large intestine to be transported and transformed.

201410103168.5 Chinese medicinal composition for treating slow-transit constipation and its preparation method disclose that the Chinese medicinal composition comprises radix rehmanniae 5-30 g, radix Angelicae sinensis 10-30 g, radix astragali 20-60 g, Cistanchis herba 10-30 g, fructus Aurantii Immaturus 10-30 g, radix et rhizoma Rhei 10-30 g, Atractylodis rhizoma 10-30 g, and Borneolum 2-15 g. Its main effect is to treat constipation of slow transit type. The medicine is cheap and easy to obtain, and the comprehensive cost is low; the traditional Chinese medicine plaster has simple preparation process, has the characteristics of direct application, definite curative effect, simple and convenient operation, small toxic and side effect, no pain and the like, and is favorable for production and clinical use. If the traditional Chinese medicine composition is used consistently according to the treatment course, the effect can be achieved within a period of time, and the traditional Chinese medicine composition has a wider development prospect compared with the traditional prescription or medicine for treating the same kind of diseases.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition external plaster for treating both symptoms and root causes of constipation.

A Chinese medicinal composition for treating constipation comprises the following Chinese medicinal raw materials and components in a mixing ratio,

5-30 g of raw rhubarb; 10-15 g of mirabilite; 2 g of peach kernel; 2 g of immature bitter orange;

2 g of magnolia officinalis; 1 g of betel nut; 1 g of white gourd kernel; 1 g of cortex moutan;

1-5 g of cimicifuga foetida; 5-10 g of liquorice.

Preferably comprises the raw materials of the traditional Chinese medicines and the components in a mixing ratio,

10 g of raw rhubarb; 10 g of mirabilite; 2 g of peach kernel; 2 g of immature bitter orange;

2 g of magnolia officinalis; 1 g of betel nut; 1 g of white gourd kernel; 1 g of cortex moutan;

1 g of cimicifuga foetida; licorice root, radix Glycyrrhizae 10 g.

A topical medicinal patch prepared from a Chinese medicinal composition for treating constipation is prepared by pulverizing the raw materials into 200-400 mesh micropowder,

mixing half weight of raw rhubarb micro powder in a formula, all peach kernel micro powder in the formula, all betel nut micro powder in the formula and all white gourd seed micro powder in the formula uniformly, putting the mixture on a bamboo-woven disc to be thin, putting the bamboo-woven disc of the medicinal powder in the middle of a vertical large iron cylinder, burning folium artemisiae argyi below the large iron cylinder to heat the medicinal powder, keeping the medicinal powder on the bamboo-woven disc at a hand-scalding temperature of 60-70 ℃, fumigating the medicinal powder for 15-20 minutes by folium artemisiae argyi smoke, and taking the medicinal powder out of the iron cylinder to prepare fumigated medicinal powder for later use;

mixing all fructus Aurantii Immaturus micropowder, cortex Magnolia officinalis micropowder, and cimicifugae rhizoma micropowder uniformly, adding small amount of 56% (v/v) Chinese liquor to make the micropowder mixed Chinese liquor just knead into mass, kneading the medicinal powder with Chinese liquor into medicinal mass with diameter of 2 cm, standing for half a day, scattering the medicinal mass, removing Chinese liquor, standing for 2 days, and making into medicinal powder;

mixing half weight of radix et rhizoma Rhei micropowder, all Natrii sulfas micropowder, all smoking medicinal powder, all wine medicinal powder, all cortex moutan micropowder, and all Glycyrrhrizae radix micropowder with dimethyl sulfoxide and vaseline to obtain paste, and mixing the above materials at a weight ratio: weight of dimethyl sulfoxide: petrolatum weight =1:1: 1; each external plaster is prepared by taking 3 g of the pasty medicine, putting the pasty medicine into an external medicine applying adhesive plaster, sterilizing and packaging.

The packaging method comprises the following steps: 3 g of sterilized pasty medicine is taken and filled into a plaster with the diameter of 7 x 7cm and the inner diameter of 3 x 3cm, and then the plaster is sterilized and packaged. The use method of the patient comprises the following steps: the external medicinal plaster is used by a patient once a day, the medicinal surface of the external medicinal plaster is pasted on the Shenque acupoint for about 3-6 hours, and then the external medicinal plaster is taken down and discarded.

The patent constipation plaster has a prescription theoretical basis: constipation is a large intestine disease characterized clinically by difficulty in defecation due to disorder of the large intestine, and prolonged defecation time or defecation interval. The disease has the excess syndrome, pathogenic factors stagnate in large intestine, and fu-organ qi obstruction is obstructed; deficiency syndrome due to the failure of the intestines to warm and moisten, resulting in dysfunction of the large intestine in conduction. The disease is located in the large intestine and closely related to the lung, liver, kidney, spleen and stomach, and constipation is accumulated in the intestines and stomach, which easily causes qi movement up and down retardation, even qi stagnation and blood stasis. Often repeated attacks, lingering and unhealed, and entering collaterals for a long time, which causes stasis of the gastrointestinal collaterals. The patent aims at the characteristic of deficiency and excess inclusion, and treats constipation by using a monarch, a minister, a four adjuvant and four conductions to relax bowels and remove stagnation. The formula of the patent has the following effects that:

firstly, a monarch drug: raw rhubarb: bitter and cold in property, unblocking and descending, purgative, promoting blood circulation to remove blood stasis, and cleaning up and purging the accumulated food in the stomach and intestine.

One minister: mirabilite: being bitter and cold in nature, it is good at purging heat and relaxing bowels, moistening dryness and softening hard masses, and helps Da Huang to promote its rapid action as a minister.

Four-adjuvant: licorice, peach kernel, immature bitter orange, magnolia bark: the liquorice has the functions of strengthening the spleen and replenishing qi, detoxifying and relieving urgency, harmonizing the other drugs, strengthening the body resistance to eliminate pathogenic factors, dredging the intestines without damaging the body resistance, ascending and descending the qi activity, dredging the collaterals of the intestines and strengthening the defecation. Peach kernel is used for relaxing bowel, promoting blood circulation and removing blood stasis; fructus Aurantii Immaturus and cortex Magnolia officinalis have effects of promoting qi circulation, resolving food stagnation, eliminating dampness, and eliminating fullness; the four medicines are assisted with the rhubarb mirabilite to promote the circulation of qi and purge the bowels, purge and relax the bowels.

Fourthly, the following steps: betel nut, white gourd seed, cortex moutan and cimicifugae foetidae: bing Lang breaks accumulation and purges qi, pungent, bitter and purgative, it can promote qi circulation and remove accumulation to remove stagnation, and also purges slowly to relieve constipation; the white gourd seed has the effects of moistening dryness, relaxing bowels, inducing diuresis and relieving swelling; cortex moutan has effects in cooling blood and dispelling blood stasis; cimicifugae rhizoma has effects of invigorating yang, lifting sinking, invigorating stomach and intestine, and clearing yang while turbid yin is descending, so as to relieve constipation; the liquorice invigorates the spleen and tonifies qi, detoxifies and relieves urgency, harmonizes other medicines, strengthens the body resistance to eliminate pathogenic factors, and enables intestines to be communicated without damaging the body resistance; they are used together as guiding drugs to promote qi movement, dredge the collaterals of the intestinal tract and strengthen the action of relaxing bowels.

The patent formula has the medical treatment effect on various symptoms of constipation:

the Chinese medicinal composition is mainly used for treating pathogenic stagnation large intestine, and is prepared from rhubarb, mirabilite, immature bitter orange, magnolia officinalis, cortex moutan and betel nut, wherein the rhubarb in the formula is bitter and cold, enters stomach channels and large intestine channels to push old to cause novelty, washes out accumulation stagnation, regulates middle energizer to digest, purges and defecates, is salty and cold in mirabilite, enters stomach channels, large intestine channels and small intestine channels to purge heat and defecate, soften hardness and moisten dryness; the cortex moutan is bitter and cold, enters lung meridian, and the lung and the large intestine are exterior and interior, so that the cortex moutan can remove pathogenic qi in blood system, clear heat and cool blood, and promote blood circulation and remove blood stasis; bing Lang is pungent and bitter with the action of dispersing and purging, enters stomach and large intestine meridians, moves qi and relieves food stagnation to relieve constipation. The medicines are combined to play the role of clearing the fu-organs and removing stagnation.

For treating intestinal dysfunction, semen Persicae and semen Benincasae are mainly used, and semen Persicae in the formula has effects of loosening bowel to relieve constipation, promoting blood circulation and removing blood stasis; the white gourd seed has the effects of moistening dryness, relaxing bowels, inducing diuresis and relieving swelling; the two kernels are combined to moisten intestines for relaxing bowels, and are used for constipation due to intestinal dryness.

For treating weakness, the liquorice and the cimicifuga foetida are mainly used for improving yang qi and are used for treating weakness due to deficiency of middle qi, the liquorice is used for tonifying qi, tonifying spleen and relieving pain and is used for treating constipation with abdominal distention and pain, and the liquorice is combined with the cimicifuga foetida for enhancing the effects of tonifying qi and strengthening spleen, and the liquorice and the cimicifuga foetida are used for treating symptoms of intestinal warmness and weakness.

Vaseline protects the skin, keeps the medicine moist and prevents the external medicine from generating allergy; dimethyl sulfoxide has the function of transdermal agent, has solubility to medicine, helps dissolved medicine permeate human skin, stimulates nerve endings, expands blood vessels through reflection, promotes local blood circulation, increases medicine absorption and improves curative effect, and is attached to Shenque acupoint, and utilizes abundant capillary network around umbilicus to absorb medicine, so that the curative effect is better. The external preparation has obvious effects of promoting qi circulation and clearing hollow viscera without damaging the stomach and the intestine, can regulate the functions of the stomach and the intestine, and is an ideal external treatment prescription for treating constipation at present

The specific cure patient cases of the traditional Chinese medicine composition for treating constipation prepared by the method are as follows:

case 1, old, male, 75 years old, new optical path in Wuhou district of metropolis,

the medical history: before the medical plaster is used for treatment, patients have dry stools in the course of disease for 2 years and 2016, difficult-to-defecate is performed once for 3-4 days, unsmooth defecate is realized, anus is fallen and expanded during defecate, defecating is hard to take, and defecating is uncomfortable.

The existing treatment medicines are as follows: 2019-03-11 to 04-09, and the medicinal patch is applied to the navel (Shenque acupoint) for 6 hours every day, once a day and one patch every day.

Has the following effects: when 3 days of defecation occur on the 3 rd day of treatment, the defecation is smooth, the anus is plump, the defecation is labor-consuming, and the defecation is uncomfortable.

And (3) healing: on the 10 th day, the patient defecates 1 time a day, the patient feels soft and has smooth defecation, slight anus plumpness in defecation and discomfort after defecation disappear.

Case 2, fan Yi, woman, age 85, three lanes in north station west of Chengdu area,

the medical history: before the plaster is used for treatment, patients have hard stool before 2 years and half years, and the enema is used for plugging the anus to help defecation for a long time. At present, patients defecate once in 3 days, the defecate is hard and is in a separated hard ball shape, the abdominal distension and pain before defecating, the obvious blocking feeling and the dropping and swelling feeling during defecating, the defecating is hard, and the defecating is not thorough after defecating. The suppository is used to plug anus by itself, and is not treated normally.

The existing treatment medicines are as follows: 2019-9-03-13 to 05-09, the medicinal patch is applied to the navel (Shenque acupoint) for 6 hours every day, once a day and one patch every day.

Has the following effects: when the patient defecates for 3 days on the 5 th day, the abdominal distension and the abdominal pain before defecating are relieved, the defecation is smoother, the anus falls and swells, the blocking feeling is caused, the defecation is labor-consuming, and the patient is uncomfortable after defecating.

And (3) healing: when the patient defecates 1 day 1 time on the 13 th day of treatment, the patient defecates softly, defecates smoothly, slightly abdominal pain and abdominal distension before defecating, slightly anal pendant swelling feeling during defecating, no blocking feeling and discomfort after defecating disappear.

Case 3, hu zhi, man, age 75, da zhou shi gao xian zhu county,

the medical history: the patients have difficulty in constipation 2 years ago, and the constipation is not obviously improved after the treatment in an external hospital (not detailed). At present, patients defecate once in 3-4 days, the defecate is dry and hard, the patients are relieved with unsmooth defecating, the anus is plump in the defecating process, the defecating is hard, and the defecating is uncomfortable.

The existing treatment medicines are as follows: 2019-07-19 to 08-14, the medicinal patch is applied to the navel (Shenque acupoint) for 6 hours every day, once a day and one patch every day.

Has the following effects: when 3 days of defecation occur on the 3 rd day of treatment, the defecation is smooth, the anus is plump, the defecation is labor-consuming, and the defecation is uncomfortable.

And (3) healing: on the 10 th day, the patient defecates 1 time a day, the patient feels soft and has smooth defecation, slight anus plumpness in defecation and discomfort after defecation disappear.

Case 4, Zhangzhi, woman, 95 years old, Sichuan province, in the city of the Lonicera,

the medical history: the patient has difficulty in defecating 3 years ago, and has no obvious improvement on the symptoms after long-term hospital treatment (detailed). At present, patients defecate once in 4 days, the defecate is dry and hard, the patients are relieved with unsmooth defecating, the anus is plump during defecating, the defecating is hard, and the defecating is uncomfortable.

The existing treatment medicines are as follows: 2019-08-08 to 08-27, the medicinal patch is used for treating by being applied to the navel (Shenque acupoint) for 6 hours every day, once a day and one patch every day.

Has the following effects: when 3 days of defecation occur on the 3 rd day of treatment, the defecation is smooth, the anus is plump, the defecation is labor-consuming, and the defecation is uncomfortable.

And (3) healing: when the patient defecates 1 day 1 time on the 13 th day of treatment, the patient feels soft and has smooth defecation, slight anus plumpness feeling occurs during defecation, and discomfort feeling disappears after defecation.

Scoring criteria for efficacy are as follows:

item	Scoring standard (score of serious illness is high)
		Frequency of defecation	0 minute is set for 1 time or more in two days; 1 time in 3 days is 1 minute; 2 times per week for 2 minutes; 3 minutes for 1 time per week; 4 minutes less than 1 time per week.
Stool characteristics	Type 1: an isolated hard mass; type 2: a block shape; type 3: a dry cracked sausage shape; type 4: soft sausage-like; type 5: a soft mass; type 6: slurry-like; type 7: water sample is easy. Wherein 5-7 types are marked with 0 point, 4 types are marked with 1 point, and 3 types are marked with Type 2, type 3, and type 1, type 4.
		Degree of effort for defecation	No score of 0 at all; rarely, hardly 1 point; sometimes 2 points; usually 3 points; always for 4 minutes.
Feeling of incomplete defecation	No score of 0 at all; rarely, hardly 1 point; sometimes 2 points; usually 3 points; always for 4 minutes.
		Abdominal distention and fullness	No score of 0 at all; rarely, hardly 1 point; sometimes 2 points; usually 3 points; always for 4 minutes.
Abdominal pain	No score of 0 at all; rarely, hardly 1 point; sometimes 2 points; usually 3 points; always for 4 minutes.
		Sense of anal obstruction	No score of 0 at all; rarely, hardly 1 point; sometimes 2 points; usually 3 points; always for 4 minutes.
Feeling of anal pendant expansion	0 min, no drop and expansion feeling; 1 minute, the pendant swelling feeling disappears after a moment; 2 minutes, the feeling of falling and swelling disappears after defecation; 3 minutes, the toilet is frequently accessed, but the toilet still has a falling and swelling feeling; always, the feeling of falling and swelling is 4 minutes.

The invention has the advantages that: the medicine is common and cheap, and the preparation cost is low; the traditional Chinese medicine plaster has simple preparation process, has the characteristics of direct application, definite curative effect, simple and convenient operation, small toxic and side effect, no pain and the like, and is favorable for production and clinical use. If the traditional Chinese medicine composition is used consistently according to the treatment course, the effect can be achieved within a period of time, and the traditional Chinese medicine composition has a wider development prospect compared with the traditional prescription or medicine for treating the same kind of diseases.

The acupoint application therapy of the formula directly stimulates the Shenque acupoint through medicaments, the body surface vein at the acupoint is rich, the channels and collaterals are communicated from outside to inside, qi and blood are promoted, the focus is reached, and the effect of increasing and eliminating pathogenic factors by promoting medicament absorption is obvious; the acupoint application does not pass through gastrointestinal administration, does not damage the defect of spleen and stomach, and does not make a last attack on the treatment, does not make a last attack on the treatment and does not make a last attack on the treatment; the medicine is common and cheap, and the preparation cost is low; the preparation process of the traditional Chinese medicine plaster is simple; the acupoint application therapy integrates the advantages of acupuncture and drug therapy, the compatibility and composition of the used medicines are mostly from clinical experience, the curative effect is obvious, no wound and no pain exist, and the medicine is especially suitable for patients who are afraid of acupuncture, old and young weak bodies, and patients who are difficult to apply reinforcing and reducing medicine or people who are not sure to take medicine and cannot take medicine; if the traditional Chinese medicine composition is used consistently according to the treatment course, the effect can be achieved within a period of time, and the traditional Chinese medicine composition has a wider development prospect compared with the traditional prescription or medicine for treating the same kind of diseases.

The invention is mainly stomach-regulating qi-supporting decoction, wherein the rhubarb, the mirabilite and the liquorice are used in large amounts in the formula and mainly treat yang-invigorating stomach and intestine dryness-heat syndrome, the rhubarb is bitter and cold in order to purge heat and relax bowels and wash intestines and stomach, the mirabilite is salty and cold in order to purge heat and remove heat and soften hardness and moisten dryness, the liquorice is used for treating constipation with abdominal distention and pain, and is matched with the cimicifuga foetida to enhance the qi-invigorating and spleen-tonifying functions of the cimicifuga foetida for treating intestinal dysfunction and weakness-promoting, the immature bitter orange breaks through pungent and binds, promotes qi circulation and removes stasis, the magnolia bark is bitter and qi-warming and eliminates turgor, the peach kernel and the white gourd seed kernel are added in the formula for enhancing the intestine dryness and constipation, the areca nut is bitter in taste, enters stomach and intestine channels, can eliminate stagnation and descend qi, is used for constipation and abdominal pain with pathogenic factors, the cimicifuga foetida can promote yang qi-warming for treating deficiency and insufficiency of middle qi-promoting, has the effects of clearing heat and cooling blood, and promoting blood circulation and removing blood stasis.

Detailed Description

Example 1A patch for external use prepared with a Chinese medicinal composition for treating constipation

The external medicine patch is composed of the following traditional Chinese medicine raw materials and components according to the mixing ratio,

5-30 g of raw rhubarb; 10-15 g of mirabilite; 2 g of peach kernel; 2 g of immature bitter orange;

2 g of magnolia officinalis; 1 g of betel nut; 1 g of white gourd kernel; 1 g of cortex moutan;

1-5 g of cimicifuga foetida; 5-10 g of liquorice.

The processing and using method of the traditional Chinese medicine raw materials comprises the following steps: pulverizing the raw materials into 200-400 mesh micropowder,

mixing half weight of raw rhubarb micro powder in a formula, all peach kernel micro powder in the formula, all betel nut micro powder in the formula and all white gourd seed micro powder in the formula uniformly, putting the mixture on a bamboo-woven disc to be thin, putting the bamboo-woven disc of the medicinal powder in the middle of a vertical large iron cylinder, burning folium artemisiae argyi below the large iron cylinder to heat the medicinal powder, keeping the medicinal powder on the bamboo-woven disc at a hand-scalding temperature of 60-70 ℃, fumigating the medicinal powder for 15-20 minutes by folium artemisiae argyi smoke, and taking the medicinal powder out of the iron cylinder to prepare fumigated medicinal powder for later use;

mixing all fructus Aurantii Immaturus micropowder, cortex Magnolia officinalis micropowder, and cimicifugae rhizoma micropowder uniformly, adding small amount of 56% (v/v) Chinese liquor to make the micropowder mixed Chinese liquor just knead into mass, kneading the medicinal powder with Chinese liquor into medicinal mass with diameter of 2 cm, standing for half a day, scattering the medicinal mass, removing Chinese liquor, standing for 2 days, and making into medicinal powder;

mixing half weight of radix et rhizoma Rhei micropowder, all Natrii sulfas micropowder, all smoking medicinal powder, all wine medicinal powder, all cortex moutan micropowder, and all Glycyrrhrizae radix micropowder with dimethyl sulfoxide and vaseline to obtain paste, and mixing the above materials at a weight ratio: weight of dimethyl sulfoxide: petrolatum weight =1:1: 1; each external plaster is prepared by taking 3 g of the pasty medicine, putting the pasty medicine into an external medicine applying adhesive plaster, sterilizing and packaging.

The packaging method comprises the following steps: 3 g of sterilized pasty medicine is taken and filled into a plaster with the diameter of 7 x 7cm and the inner diameter of 3 x 3cm, and then the plaster is sterilized and packaged. The use method of the patient comprises the following steps: the external medicinal plaster is used by a patient once a day, the medicinal surface of the external medicinal plaster is pasted on the Shenque acupoint for about 3-6 hours, and then the external medicinal plaster is taken down and discarded.

Case 1, old, male, 75 years old, new optical path in Wuhou district of metropolis,

the record of the efficacy scores of the patients during the treatment period from 2019-03-11 to 04-09 is as follows (the score of the disease severity is high):

during the treatment period	03-11	03-14	03-17	03-25	04-09
						Total score of therapeutic effect	31	22	16	1	0
Frequency of defecation	3	2	2	1	0
						Stool characteristics	4	3	2	0	0
Waste and defecate	4	3	2	0	0
						Feeling of incomplete defecation	4	3	2	0	0
Abdominal distention and fullness	4	3	2	0	0
						Abdominal pain	4	3	2	0	0
Sense of anal obstruction	4	2	2	0	0
						Feeling of anal pendant expansion	4	3	2	0	0
Time for pasting	5 hours	6 hours	6 hours	6 hours	6 hours
						Symptoms and signs	A week of defecation with dry stools Unsmooth discharge, a feeling of anal distention during defecation The user can feel hard and uncomfortable after defecating.	Defecate 2 times a week Dry and hard, the defecation is smoother than before, anus falling and expanding feeling during defecation and defecation Hard to do and uncomfortable after defecation.	Feces change after 3-4 times a day and 1 time Soft, smooth defecation and defecation The feeling of anal pendant expansion is reduced, the stool The unpleasant feeling after eating is relieved.	1-2 times a day for stool and stool quality Soft, strip-shaped, and smooth for defecation Smooth defecation without anus falling and expansion Feel uncomfortable after defecation.	1-2 times a day, soft stool and self-relieving stool Smooth and easy, no sense of anal pendant expansion during defecation, no Anal obstruction and discomfort after defecation.

Example 2A patch for external use prepared with a Chinese medicinal composition for treating constipation

The external medicine patch is composed of the following traditional Chinese medicine raw materials and components according to the mixing ratio,

10 g of raw rhubarb; 15 g of mirabilite; 2 g of peach kernel; 2 g of immature bitter orange;

2 g of magnolia officinalis; 1 g of betel nut; 1 g of white gourd kernel; 1 g of cortex moutan;

1 g of cimicifuga foetida; licorice root, radix Glycyrrhizae 5 g.

The processing and using method of the traditional Chinese medicine raw materials comprises the following steps: was used in example 1.

Case 2, fan Yi, woman, age 85, Chengdu Jinniu district northwest station three lanes

The record of the efficacy scores of the patients during the treatment period of 2019-04-13 to 05-09 is as follows (the score of the disease severity is high):

during the treatment period	04-13	04-17	04-19	04-27	05-09
						Total score of therapeutic effect	29	22	15	5	0
Frequency of defecation	1	1	1	0	0
						Stool characteristics	4	3	3	3	0
Waste and defecate	4	3	2	0	0
						Feeling of incomplete defecation	4	4	2	0	0
Abdominal distention and fullness	4	3	2	2	0
						Abdominal pain	4	3	2	0	0
Sense of anal obstruction	4	2	1	0	0
						Feeling of anal pendant expansion	4	3	2	0	0
Time for pasting	6 hours	6 hours	6 hours	5 hours	5 hours
						Symptoms and signs	The excrement is hard after being taken for 3 days, in the form of separated hard balls, the abdomen before defecation Abdominal pain, obvious obstruction in defecation, A feeling of falling and swelling, a great effort to defecate and a feeling of going after defecation Defecation is not enough.	Defecation is once in 3 days, and the abdomen before defecation A distending abdominal pain relieved and defecation earlier Smooth and easy anus plumpness in defecation Feeling of obstruction, and wasting the defecating effort, the defecation is uncomfortable.	The stool is in the form of block mass and the abdomen is distended before defecation Obviously relieve the abdominal pain and relieve the bowels More smooth and easy, and the feeling of blocking and falling during defecation The feeling of fullness is reduced, and the feeling of non-refreshing after defecation is relieved And (5) solving.	The stool is soft 1 time a day Sausage-like, no pain in the front abdomen and slight abdominal pain No blocking feeling and anus opening during defecation A feeling of falling and swelling, and uncomfortable feeling after defecation.	Defecation 1 time a day, soft stool, no stool before defecation Abdominal distension and pain, smooth stool self-release, no sensation after defecation.

Example 3A patch for external use prepared with a Chinese medicinal composition for treating constipation

The external medicine patch is composed of the following traditional Chinese medicine raw materials and components according to the mixing ratio,

10 g of raw rhubarb; 10 g of mirabilite; 2 g of peach kernel; 2 g of immature bitter orange;

2 g of magnolia officinalis; 1 g of betel nut; 1 g of white gourd kernel; 1 g of cortex moutan;

1 g of cimicifuga foetida; licorice root, radix Glycyrrhizae 10 g.

The processing and using method of the traditional Chinese medicine raw materials comprises the following steps: was used in example 1.

Case 3, hu zhi, man, age 75, da zhou shi gao xian zhu county,

the record of the efficacy scores of the patients during the treatment period from 2019-07-19 to 08-14 is as follows (the score of the disease severity is high):

during the treatment period	07-19	07-22	07-29	08-02	08-14
						Total score of therapeutic effect	27	16	8	1	0
Frequency of defecation	1	1	1	1	0
						Stool characteristics	2	1	1	0	0
Waste and defecate	4	3	1	0	0
						Feeling of incomplete defecation	4	3	1	0	0
Abdominal distention and fullness	4	2	1	0	0
						Abdominal pain	4	2	1	0	0
Sense of anal obstruction	4	2	1	0	0
						Feeling of anal pendant expansion	4	2	1	0	0
Time for pasting	4 hours	6 hours	5 hours	5 hours	3 hours
						Symptoms and signs	The stool is dry after 3-4 days Nodulation, unsmooth discharge and retention of stool A feeling of falling and swelling, a great effort to defecate and a person who is in a defecation It is not refreshing.	The patient defecates 3 times a day and 1 time Dry and hard, the defecation is smoother than before, anus falling and expanding feeling during defecation and defecation Hard to do and uncomfortable after defecation.	Defecating smoothly and regularly Slight anal pendant and distention feeling The unpleasant feeling disappears.	1-2 times a day, the stool is soft and in the appearance Strip shape, smooth defecation and defecation No sense of anal pendant expansion and no constipation Refreshing.	The patient defecates 1 day to 2 times, has soft stool and self-defecation Smooth and easy to relieve, no sense of anal pendant expansion during defecation, no Anal obstruction and discomfort after defecation.

Example 4A patch for external use prepared with a Chinese medicinal composition for treating constipation

The external medicine patch is composed of the following traditional Chinese medicine raw materials and components according to the mixing ratio,

5 g of raw rhubarb; 10 g of mirabilite; 2 g of peach kernel; 2 g of immature bitter orange;

2 g of magnolia officinalis; 1 g of betel nut; 1 g of white gourd kernel; 1 g of cortex moutan;

5 g of cimicifuga foetida; licorice root, radix Glycyrrhizae 10 g.

The processing and using method of the traditional Chinese medicine raw materials comprises the following steps: was used in example 1.

Case 4, Zhangzhi, woman, 95 years old, Sichuan province, in the city of the Lonicera,

the record of the efficacy scores of the patients during the treatment period from 2019-08-08 to 08-27 is as follows (the score of the disease severity is high):

during the treatment period	08-08	08-11	08-18	08-22	08-27
						Total score of therapeutic effect	28	23	13	0	0
Frequency of defecation	3	2	0	1	0
						Stool characteristics	4	3	1	0	0
Waste and defecate	4	3	2	0	0
						Feeling of incomplete defecation	4	2	2	0	0
Abdominal distention and fullness	4	3	2	0	0
						Abdominal pain	3	3	2	0	0
Sense of anal obstruction	3	4	2	0	0
						Feeling of anal pendant expansion	3	3	2	0	0
Time for pasting	6 hours	6 hours	5 hours	5 hours	4 hours
						Symptoms and signs	The patient defecates once in 4 days Dry and hard to get out of the anus The door falls and expands, the defecation is hard and the defecation is easy The feeling is not comfortable.	The patient defecates 3 times a day and 1 time Dry and hard, the defecation is smoother than before, anus falling and expanding feeling during defecation and defecation Hard to do and uncomfortable after defecation.	The patient defecates 2 times a day and 1 time, and the stool quality The defecation is smoother than before, the sense of anal pendant expansion is reduced when in use, relieving uncomfortable feeling after defecation.	The patient defecates 1 to 2 times a day Soft, strip-shaped, for defecation Smooth and no anus drop during defecation Distending sensation, uncomfortable feeling after defecation.	The patient defecates 1 day to 2 times, has soft stool and self-defecation Smooth and easy to relieve, no sense of anal pendant expansion during defecation, no Anal obstruction and discomfort after defecation.

Claims (3)

1. A Chinese medicinal composition for treating constipation comprises the following Chinese medicinal raw materials and components in a mixing ratio,

5-30 g of raw rhubarb; 10-15 g of mirabilite; 2 g of peach kernel; 2 g of immature bitter orange;

2 g of magnolia officinalis; 1 g of betel nut; 1 g of white gourd kernel; 1 g of cortex moutan;

1-5 g of cimicifuga foetida; 5-10 g of liquorice.

2. The traditional Chinese medicine composition for treating constipation according to claim 1, which is characterized in that: comprises the following Chinese medicinal raw materials and components in a mixing ratio,

10 g of raw rhubarb; 10 g of mirabilite; 2 g of peach kernel; 2 g of immature bitter orange;

2 g of magnolia officinalis; 1 g of betel nut; 1 g of white gourd kernel; 1 g of cortex moutan;

1 g of cimicifuga foetida; licorice root, radix Glycyrrhizae 10 g.

3. A patch for external use prepared from the Chinese medicinal composition for treating constipation according to claim 1 or 2,

pulverizing the raw materials into 200-400 mesh micropowder,

mixing half weight of raw rhubarb micro powder in a formula, all peach kernel micro powder in the formula, all betel nut micro powder in the formula and all white gourd seed micro powder in the formula uniformly, putting the mixture on a bamboo-woven disc to be thin, putting the bamboo-woven disc of the medicinal powder in the middle of a vertical large iron cylinder, burning folium artemisiae argyi below the large iron cylinder to heat the medicinal powder, keeping the medicinal powder on the bamboo-woven disc at a hand-scalding temperature of 60-70 ℃, fumigating the medicinal powder for 15-20 minutes by folium artemisiae argyi smoke, and taking the medicinal powder out of the iron cylinder to prepare fumigated medicinal powder for later use;

mixing all fructus Aurantii Immaturus micropowder, cortex Magnolia officinalis micropowder, and cimicifugae rhizoma micropowder uniformly, adding small amount of 56% (v/v) Chinese liquor to make the micropowder mixed Chinese liquor just knead into mass, kneading the medicinal powder with Chinese liquor into medicinal mass with diameter of 2 cm, standing for half a day, scattering the medicinal mass, removing Chinese liquor, standing for 2 days, and making into medicinal powder;

mixing half weight of radix et rhizoma Rhei micropowder, all Natrii sulfas micropowder, all smoking medicinal powder, all wine medicinal powder, all cortex moutan micropowder, and all Glycyrrhrizae radix micropowder with dimethyl sulfoxide and vaseline to obtain paste, and mixing the above materials at a weight ratio: weight of dimethyl sulfoxide: petrolatum weight =1:1: 1; each external plaster is prepared by taking 3 g of the pasty medicine, putting the pasty medicine into an external medicine applying adhesive plaster, sterilizing and packaging.