CN111700886A - Compound allicin soft capsule and preparation and packaging method thereof - Google Patents
Compound allicin soft capsule and preparation and packaging method thereof Download PDFInfo
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- CN111700886A CN111700886A CN202010328287.6A CN202010328287A CN111700886A CN 111700886 A CN111700886 A CN 111700886A CN 202010328287 A CN202010328287 A CN 202010328287A CN 111700886 A CN111700886 A CN 111700886A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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Abstract
The invention discloses a compound allicin soft capsule and a preparation and packaging method thereof, wherein the compound allicin soft capsule comprises capsule contents and capsule skin, and the capsule contents comprise the following components in percentage by mass: allicin: 1% -65% and houttuynin: 1-55 percent, and the capsule skin comprises the following components in percentage by mass: sizing and excipient: 10% -20%, plasticizer: 1-10%, additive: 1-10% and water: 50% -80%, the beneficial effect of the invention is: the allicin and the houttuynine sodium bisulfite are mixed fully to prepare the broad spectrum antibiotic medicine with definite curative effect, long-term taking and no toxic side effect, and the medicine has clear components and definite action mechanism, and avoids the defects of complex traditional Chinese medicine components and unknown pharmacological action mechanism, and the defects of great toxic and side effect of chemical medicine and long-term taking.
Description
Technical Field
The invention relates to the technical field of clinical application, in particular to a compound allicin soft capsule and a preparation and packaging method thereof.
Background
With the aging development of population and the abuse of antibiotics, common clinical double infection and double infection are increasing day by day, common antibiotics such as penicillin antibiotics and cephalosporin antibiotics are artificially synthesized modified compounds and have the defects of strong drug resistance and large toxic and side effects, most common clinical chronic diseases are old patients, most of the patients have multi-organ diseases with liver and kidney insufficiency, the toxic and side effects are increased when various drugs such as antibiotics and lipid-lowering drugs are used together, and the prognosis is poor, so that a broad-spectrum antibacterial drug which has definite curative effect, can be taken for a long time and has no toxic and side effects needs to be researched.
Disclosure of Invention
The invention aims to provide a compound allicin soft capsule and a preparation and packaging method thereof, which aim to solve the problems in the background technology.
In order to realize the purpose, the invention provides the following technical scheme that the compound allicin soft capsule consists of capsule contents and a capsule skin, wherein the capsule contents comprise the following components in percentage by mass: allicin: 1% -65% and houttuynin: 1% -55%, wherein the capsule shell comprises the following components in percentage by mass: sizing and excipient: 10% -20%, plasticizer: 1-10%, additive: 1-10% and water: 50 to 80 percent.
Preferably, the allicin has the chemical formula C6H10S3And the garlicin is obtained by purifying natural plant garlic or artificially synthesizing.
Preferably, the houttuynine sodium bisulfite has chemical formula C12H22O2The houttuynin is obtained by purifying or artificially synthesizing natural plant houttuynia cordata.
Preferably, the sizing excipient is gelatin.
Preferably, the plasticizer is sorbitol or glycerol.
Preferably, the additive is a fragrance, a preservative or an opacifier.
A preparation and packaging method of a compound allicin soft capsule comprises the following steps:
s1, preparing a solution I: weighing allicin according to the formula proportion, adding into partial water, heating and stirring until the allicin is completely dissolved;
s2, preparing a solution II: weighing houttuynin according to the formula proportion, adding part of water, mixing uniformly, and stirring to dissolve completely;
s3, mixing and stirring: adding a certain amount of the first solution into a certain amount of the second solution according to the formula proportion, and stirring until the first solution is completely dissolved to obtain a mixed solution;
s4, preparing a capsule shell glue solution: weighing gelatin, plasticizer, additive and water according to a formula ratio, firstly putting the gelatin into the water, soaking to swell the gelatin, adding the plasticizer and the additive after the gelatin is dissolved, and then mixing and stirring uniformly to obtain capsule shell glue solution;
s5, preparing a capsule shell: uniformly coating the capsule shell glue solution obtained in the step (4) on the surface of a flat plate, and then heating at the temperature of about 90 ℃ to evaporate the water on the surface of the capsule shell glue solution to obtain a soft capsule with certain toughness;
s6, pressing soft capsules: putting the soft capsule obtained in the step 5 on an automatic rotary capsule pricking machine, adding the mixed solution obtained in the step 3, and pressing into soft capsules;
s7, packaging and warehousing: and (4) drying the soft capsules obtained in the step (6), inspecting the soft capsules, sterilizing at 55 ℃ after the soft capsules are qualified, then externally packaging the soft capsules, and warehousing and storing the soft capsules.
Compared with the prior art, the invention has the beneficial effects that:
the allicin and the houttuynine sodium bisulfite are mixed fully to prepare the broad spectrum antibiotic medicine with definite curative effect, long-term taking and no toxic side effect, and the medicine has clear components and definite action mechanism, and avoids the defects of complex traditional Chinese medicine components and unknown pharmacological action mechanism, and the defects of great toxic and side effect of chemical medicine and long-term taking.
Detailed Description
The invention provides a technical scheme that: a compound allicin soft capsule consists of capsule contents and a capsule skin, wherein the capsule contents comprise the following components in percentage by mass: allicin: 1% -65% and houttuynin: 1% -55%, wherein the capsule shell comprises the following components in percentage by mass: sizing and excipient: 10% -20%, plasticizer: 1-10%, additive: 1-10% and water: 50 to 80 percent.
Wherein the chemical formula of the allicin is C6H10S3And the garlicin is obtained by purifying natural plant garlic or artificially synthesizing.
Wherein the houttuynin has a chemical formula of C12H22O2The houttuynin is obtained by purifying or artificially synthesizing natural plant houttuynia cordata.
Wherein the sizing excipient is gelatin.
Wherein the plasticizer is sorbitol or glycerol.
Wherein the additive is a perfume, a preservative or an opacifier.
A preparation and packaging method of a compound allicin soft capsule comprises the following steps:
s1, preparing a solution I: weighing allicin according to the formula proportion, adding into partial water, heating and stirring until the allicin is completely dissolved;
s2, preparing a solution II: weighing houttuynin according to the formula proportion, adding part of water, mixing uniformly, and stirring to dissolve completely;
s3, mixing and stirring: adding a certain amount of the first solution into a certain amount of the second solution according to the formula proportion, and stirring until the first solution is completely dissolved to obtain a mixed solution;
s4, preparing a capsule shell glue solution: weighing gelatin, plasticizer, additive and water according to a formula ratio, firstly putting the gelatin into the water, soaking to swell the gelatin, adding the plasticizer and the additive after the gelatin is dissolved, and then mixing and stirring uniformly to obtain capsule shell glue solution;
s5, preparing a capsule shell: uniformly coating the capsule shell glue solution obtained in the step (4) on the surface of a flat plate, and then heating at the temperature of about 90 ℃ to evaporate the water on the surface of the capsule shell glue solution to obtain a soft capsule with certain toughness;
s6, pressing soft capsules: putting the soft capsule obtained in the step 5 on an automatic rotary capsule pricking machine, adding the mixed solution obtained in the step 3, and pressing into soft capsules;
s7, packaging and warehousing: and (4) drying the soft capsules obtained in the step (6), inspecting the soft capsules, sterilizing at 55 ℃ after the soft capsules are qualified, then externally packaging the soft capsules, and warehousing and storing the soft capsules.
The embodiment 1 discloses a compound allicin soft capsule, which consists of capsule contents and a capsule skin, wherein the capsule contents comprise the following components in percentage by mass: allicin: 60% and houttuynin: 40 percent, and the capsule skin comprises the following components in percentage by mass: gelatin: 15%, plasticizer: 5% of additive: 5% and water: 75 percent.
A preparation and packaging method of a compound allicin soft capsule comprises the following steps:
s1, preparing a solution I: weighing allicin according to the formula proportion, adding into partial water, heating and stirring until the allicin is completely dissolved;
s2, preparing a solution II: weighing houttuynin according to the formula proportion, adding part of water, mixing uniformly, and stirring to dissolve completely;
s3, mixing and stirring: adding a certain amount of the first solution into a certain amount of the second solution according to the formula proportion, and stirring until the first solution is completely dissolved to obtain a mixed solution;
s4, preparing a capsule shell glue solution: weighing gelatin, plasticizer, additive and water according to a formula ratio, firstly putting the gelatin into the water, soaking to swell the gelatin, adding the plasticizer and the additive after the gelatin is dissolved, and then mixing and stirring uniformly to obtain capsule shell glue solution;
s5, preparing a capsule shell: uniformly coating the capsule shell glue solution obtained in the step (4) on the surface of a flat plate, and then heating at the temperature of about 90 ℃ to evaporate the water on the surface of the capsule shell glue solution to obtain a soft capsule with certain toughness;
s6, pressing soft capsules: putting the soft capsule obtained in the step 5 on an automatic rotary capsule pricking machine, adding the mixed solution obtained in the step 3, and pressing into soft capsules;
s7, packaging and warehousing: and (4) drying the soft capsules obtained in the step (6), inspecting the soft capsules, sterilizing at 55 ℃ after the soft capsules are qualified, then externally packaging the soft capsules, and warehousing and storing the soft capsules.
Embodiment 2, a compound allicin soft capsule, which consists of capsule content and capsule skin, wherein the capsule content comprises the following components in percentage by mass: allicin: 65% and houttuynin: 35 percent, and the capsule skin comprises the following components in percentage by mass: gelatin: 15%, plasticizer: 5% of additive: 5% and water: 75 percent.
A preparation and packaging method of a compound allicin soft capsule comprises the following steps:
s1, preparing a solution I: weighing allicin according to the formula proportion, adding into partial water, heating and stirring until the allicin is completely dissolved;
s2, preparing a solution II: weighing houttuynin according to the formula proportion, adding part of water, mixing uniformly, and stirring to dissolve completely;
s3, mixing and stirring: adding a certain amount of the first solution into a certain amount of the second solution according to the formula proportion, and stirring until the first solution is completely dissolved to obtain a mixed solution;
s4, preparing a capsule shell glue solution: weighing gelatin, plasticizer, additive and water according to a formula ratio, firstly putting the gelatin into the water, soaking to swell the gelatin, adding the plasticizer and the additive after the gelatin is dissolved, and then mixing and stirring uniformly to obtain capsule shell glue solution;
s5, preparing a capsule shell: uniformly coating the capsule shell glue solution obtained in the step (4) on the surface of a flat plate, and then heating at the temperature of about 90 ℃ to evaporate the water on the surface of the capsule shell glue solution to obtain a soft capsule with certain toughness;
s6, pressing soft capsules: putting the soft capsule obtained in the step 5 on an automatic rotary capsule pricking machine, adding the mixed solution obtained in the step 3, and pressing into soft capsules;
s7, packaging and warehousing: and (4) drying the soft capsules obtained in the step (6), inspecting the soft capsules, sterilizing at 55 ℃ after the soft capsules are qualified, then externally packaging the soft capsules, and warehousing and storing the soft capsules.
In the present invention, unless otherwise expressly specified or limited, the terms "mounted," "disposed," "connected," "secured," "screwed" and the like are to be construed broadly, e.g., as meaning fixedly connected, detachably connected, or integrally formed; can be mechanically or electrically connected; the terms may be directly connected or indirectly connected through an intermediate, and may be communication between two elements or interaction relationship between two elements, unless otherwise specifically limited, and the specific meaning of the terms in the present invention will be understood by those skilled in the art according to specific situations.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. The compound allicin soft capsule is characterized by comprising capsule contents and a capsule skin, wherein the capsule contents comprise the following components in percentage by mass: allicin: 1% -65% and houttuynin: 1% -55%, wherein the capsule shell comprises the following components in percentage by mass: sizing and excipient: 10% -20%, plasticizer: 1-10%, additive: 1-10% and water: 50 to 80 percent.
2. The compound allicin soft capsule of claim 1, which is characterized in that: the chemical formula of the allicin is C6H10S3And the garlicin is obtained by purifying natural plant garlic or artificially synthesizing.
3. The compound Chinese medicinal preparation according to claim 1The allicin soft capsule is characterized in that: the houttuynin has chemical formula of C12H22O2The houttuynin is obtained by purifying or artificially synthesizing natural plant houttuynia cordata.
4. The compound allicin soft capsule of claim 1, which is characterized in that: the sizing excipient is gelatin.
5. The compound allicin soft capsule of claim 1, which is characterized in that: the plasticizer is sorbitol or glycerol.
6. The compound allicin soft capsule of claim 1, which is characterized in that: the additive is perfume, antiseptic or sunscreen agent.
7. A preparation and packaging method of a compound allicin soft capsule is characterized in that: the method comprises the following steps:
s1, preparing a solution I: weighing allicin according to the formula proportion, adding into partial water, heating and stirring until the allicin is completely dissolved;
s2, preparing a solution II: weighing houttuynin according to the formula proportion, adding part of water, mixing uniformly, and stirring to dissolve completely;
s3, mixing and stirring: adding a certain amount of the first solution into a certain amount of the second solution according to the formula proportion, and stirring until the first solution is completely dissolved to obtain a mixed solution;
s4, preparing a capsule shell glue solution: weighing gelatin, plasticizer, additive and water according to a formula ratio, firstly putting the gelatin into the water, soaking to swell the gelatin, adding the plasticizer and the additive after the gelatin is dissolved, and then mixing and stirring uniformly to obtain capsule shell glue solution;
s5, preparing a capsule shell: uniformly coating the capsule shell glue solution obtained in the step (4) on the surface of a flat plate, and then heating at the temperature of about 90 ℃ to evaporate the water on the surface of the capsule shell glue solution to obtain a soft capsule with certain toughness;
s6, pressing soft capsules: putting the soft capsule obtained in the step 5 on an automatic rotary capsule pricking machine, adding the mixed solution obtained in the step 3, and pressing into soft capsules;
s7, packaging and warehousing: and (4) drying the soft capsules obtained in the step (6), inspecting the soft capsules, sterilizing at 55 ℃ after the soft capsules are qualified, then externally packaging the soft capsules, and warehousing and storing the soft capsules.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010328287.6A CN111700886A (en) | 2020-04-23 | 2020-04-23 | Compound allicin soft capsule and preparation and packaging method thereof |
| PCT/CN2020/135064 WO2021212865A1 (en) | 2020-04-23 | 2020-12-10 | Compound allicin soft capsule and method for preparing and packaging same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010328287.6A CN111700886A (en) | 2020-04-23 | 2020-04-23 | Compound allicin soft capsule and preparation and packaging method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111700886A true CN111700886A (en) | 2020-09-25 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202010328287.6A Pending CN111700886A (en) | 2020-04-23 | 2020-04-23 | Compound allicin soft capsule and preparation and packaging method thereof |
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| Country | Link |
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| CN (1) | CN111700886A (en) |
| WO (1) | WO2021212865A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021212865A1 (en) * | 2020-04-23 | 2021-10-28 | 广州宏康医药科技有限公司 | Compound allicin soft capsule and method for preparing and packaging same |
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| CN1189365A (en) * | 1997-01-31 | 1998-08-05 | 雷学军 | Medicine for preventing Aids virus, treponema pallidum, neisseria gonorrhoeae and trichomonad |
| US20060257436A1 (en) * | 2003-04-04 | 2006-11-16 | Shiseido Company, Ltd. | Skin preparation composition for external use |
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| CN100389676C (en) * | 2004-09-24 | 2008-05-28 | 江西本草天工科技有限责任公司 | Health-care food and its soft capsule for improving immunity of anti alimentary canal infection, and its prepn. method |
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| CN1879788A (en) * | 2006-05-03 | 2006-12-20 | 苟春虎 | Virus-clearing capsule |
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2020
- 2020-04-23 CN CN202010328287.6A patent/CN111700886A/en active Pending
- 2020-12-10 WO PCT/CN2020/135064 patent/WO2021212865A1/en active Application Filing
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| CN101313983A (en) * | 2008-07-02 | 2008-12-03 | 王跃进 | Compound garlic soft capsule |
| CN110158343A (en) * | 2019-05-30 | 2019-08-23 | 陈兴龙 | A kind of preparation method of antibacterial vapor-permeable type fruit inspecting |
| CN110898027A (en) * | 2019-12-12 | 2020-03-24 | 陕西鹤鸣健康科技有限公司 | Vitamin K2 (MK-7) soft capsule for promoting calcium in blood to enter bone and preparation method thereof |
Non-Patent Citations (5)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2021212865A1 (en) * | 2020-04-23 | 2021-10-28 | 广州宏康医药科技有限公司 | Compound allicin soft capsule and method for preparing and packaging same |
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