CN111700588B - Interventional imaging system - Google Patents

Interventional imaging system Download PDF

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CN111700588B
CN111700588B CN202010507656.8A CN202010507656A CN111700588B CN 111700588 B CN111700588 B CN 111700588B CN 202010507656 A CN202010507656 A CN 202010507656A CN 111700588 B CN111700588 B CN 111700588B
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imaging
terahertz
visible light
annular
fiber bundle
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CN111700588A (en
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常超
乔智
黄崟东
徐行
刘辉
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National Defense Technology Innovation Institute PLA Academy of Military Science
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National Defense Technology Innovation Institute PLA Academy of Military Science
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters

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Abstract

The embodiment of the invention provides an interventional imaging system which comprises a light source unit, a light beam shaping unit, a visible light-terahertz imaging optical fiber bundle and an imaging unit. The method comprises the steps of transmitting annular terahertz waves through an annular terahertz imaging fiber bundle in a visible light-terahertz imaging fiber bundle, transmitting visible light through the visible light imaging fiber bundle, finally receiving the visible light reflected by an imaging target and the annular terahertz waves through an imaging unit respectively, and imaging according to the received visible light and the annular terahertz waves. The method can safely and harmlessly realize the joint synchronous imaging of the interventional visible light and the terahertz waves and synchronously obtain the visible light imaging result and the terahertz imaging result, on one hand, the health hidden dangers such as radiation and the like possibly brought by the traditional imaging mode are avoided, on the other hand, medical personnel can compare the terahertz image with the visible light image, and the contrast, the readability and the accuracy of the in-vivo interventional imaging result are further improved.

Description

Interventional imaging system
Technical Field
The present invention relates to the field of optical imaging technology, and more particularly, to an interventional imaging system.
Background
In the medical field, medical personnel are often required to identify diseased regions within a patient's body by medical imaging techniques.
Currently, conventional medical Imaging techniques include X-ray Imaging, Computed Tomography (CT) Imaging, Magnetic Resonance Imaging (MRI), Ultrasound (US) Imaging, and fiber optic endoscopic Imaging. Among them, endoscopes are limited in design and process, resulting in imaging effects susceptible to noise. MRI and CT imaging are easily affected by tissue parameters, so that the imaging result comprises a plurality of layers of tissues, signals are complex, partial qualitative difficulty and easy missed diagnosis are caused, and certain limitations are realized. Furthermore, both X-ray imaging and CT imaging present radiation risks, posing a potential threat to patient health. Although the cost of US imaging is low, the imaging is obviously weaker than other imaging modes in the aspects of resolution, definition and the like, the specificity of diagnosis on pathological properties of a focus is lacked, and the examination result is easily influenced by the skill level experience of a doctor. The terahertz wave has low single photon energy and no ionization hazard, can safely image biological tissues, is widely used in the fields of biomedical detection, disease research and the like, and has great attention in the field of medical imaging. The terahertz waves have high sensitivity to interstitial water, cell density and spatial arrangement thereof, so that the terahertz imaging can effectively distinguish a lesion area.
Although terahertz imaging has advantages in the identification of lesion areas, due to the fact that terahertz wavelength is long and easy to scatter, imaging resolution is not high, and interventional imaging needs to be performed by means of a fiber bundle. Due to the high water content of the whole organism, terahertz is strongly absorbed by water, signals returned to a camera or a detector are weak, and the imaging contrast is not high, so that medical personnel cannot perform subsequent analysis of a focus and determination of a subsequent lesion area according to the imaged image.
Disclosure of Invention
To overcome or at least partially address the above problems, embodiments of the present invention provide an interventional imaging system.
The embodiment of the invention provides an interventional imaging system, which comprises: the device comprises a light source unit, a beam shaping unit, a visible light-terahertz imaging optical fiber bundle and an imaging unit;
the light source unit comprises a terahertz source and a visible light source, the terahertz source is used for emitting terahertz waves, and the visible light source is used for emitting visible light;
the beam shaping unit is used for collimating the terahertz waves and the visible light and shaping the terahertz waves to generate annular terahertz waves;
the visible light-terahertz imaging optical fiber bundle comprises an outer layer and an inner layer, wherein the outer layer is an annular terahertz imaging optical fiber bundle formed by bundling terahertz optical fibers, the inner layer is a visible light imaging optical fiber bundle formed by bundling visible light optical fibers, and the inner diameter of the annular terahertz imaging optical fiber bundle is matched with the outer diameter of the visible light imaging optical fiber bundle; the visible light imaging optical fiber bundle is used for receiving the collimated visible light and outputting the received visible light to an imaging target, and the annular terahertz imaging optical fiber bundle is used for receiving the annular terahertz waves and outputting the received annular terahertz waves to the imaging target; the visible light imaging optical fiber bundle is also used for receiving the visible light reflected by the imaging target and outputting the received visible light to the imaging unit, and the annular terahertz imaging optical fiber bundle is also used for receiving the annular terahertz waves reflected by the imaging target and outputting the received annular terahertz waves to the imaging unit;
the imaging unit is used for receiving the visible light output by the visible light imaging optical fiber bundle and the annular terahertz wave output by the annular terahertz imaging optical fiber bundle and imaging based on the received visible light and the annular terahertz wave.
Preferably, the imaging unit comprises a terahertz camera and a visible light camera;
the visible light camera is used for receiving the visible light output by the visible light imaging optical fiber bundle and imaging based on the received visible light;
the terahertz camera is specifically used for receiving the annular terahertz waves output by the annular terahertz imaging fiber bundle and imaging based on the received annular terahertz waves.
Preferably, the interventional imaging system further comprises: a first beam splitter;
the first spectroscope is arranged on a light path between the visible light-terahertz imaging optical fiber bundle and the imaging unit, and the first spectroscope is used for separating a path of visible light output by the visible light imaging optical fiber bundle in the visible light-terahertz imaging optical fiber bundle from a path of annular terahertz waves output by the annular terahertz imaging optical fiber bundle.
Preferably, the beam shaping unit specifically includes a first optical lens, a second optical lens, a spiral phase plate, and a pyramid lens;
the terahertz waves sequentially pass through the first optical lens, the spiral phase plate and the pyramid lens to generate the annular terahertz waves;
the visible light is collimated by the second optical lens.
Preferably, the annular terahertz wave is a high-order bessel terahertz beam with orbital angular momentum.
Preferably, an optical path distance between the pyramid lens and the terahertz camera is smaller than or equal to a bessel distance of the high-order bessel terahertz light beam.
Preferably, the interventional imaging system further comprises: a second spectroscope and a third spectroscope;
the second spectroscope and the third spectroscope are sequentially arranged on a light path between the beam shaping unit and the visible light-terahertz imaging optical fiber beam, and the third spectroscope is positioned on the light path between the visible light-terahertz imaging optical fiber beam and the imaging unit;
the second spectroscope is used for mixing the annular terahertz wave and the collimated visible light, so that the visible light in the obtained mixed light beam is surrounded by the annular terahertz wave, and the visible light in the mixed light beam and the annular terahertz wave are coaxial;
visible light in the mixed light beam is input into the visible light imaging fiber beam through the third beam splitter, and annular terahertz waves in the mixed light beam are input into the annular terahertz imaging fiber beam through the third beam splitter;
the third beam splitter is further configured to reflect the visible light output by the visible light imaging fiber bundle and reflected by the imaging target, and the annular terahertz wave output by the annular terahertz imaging fiber bundle and reflected by the imaging target onto the imaging unit.
Preferably, a third optical lens is further included between the third spectroscope and the visible-terahertz imaging fiber bundle; the third optical lens is used for converging the mixed light beam into the visible light-terahertz imaging optical fiber beam.
Preferably, the annular terahertz imaging fiber bundle and the visible light imaging fiber bundle each have at least two layers.
Preferably, the visible light-terahertz imaging optical fiber bundle is externally wrapped by a flexible material layer.
The embodiment of the invention provides an interventional imaging system, which comprises a light source unit, a light beam shaping unit, a visible light-terahertz imaging optical fiber beam and an imaging unit; the light source unit comprises a terahertz source and a visible light source, and the beam shaping unit is used for collimating terahertz waves and visible light and shaping the terahertz waves to generate annular terahertz waves. The method comprises the steps of transmitting annular terahertz waves through an annular terahertz imaging fiber bundle in a visible light-terahertz imaging fiber bundle, transmitting visible light through the visible light imaging fiber bundle, finally receiving the visible light reflected by an imaging target and the annular terahertz waves through an imaging unit respectively, and imaging according to the received visible light and the annular terahertz waves. The visible light-terahertz imaging optical fiber bundle and the imaging unit can safely and harmlessly realize the joint synchronous imaging of the interventional visible light and the terahertz wave, and synchronously obtain the visible light imaging result and the terahertz imaging result, so that on one hand, the health hidden dangers such as radiation and the like possibly brought by the traditional imaging mode are avoided, on the other hand, medical personnel can compare the terahertz image with the visible light image, the contrast, readability and accuracy of the in-vivo interventional imaging result are further improved, the medical personnel are assisted to identify the lesion area of the imaging target, the identification effect of the imaging target is improved, the misdiagnosis possibly brought by the single imaging result in the prior art is reduced, and the diagnosis and treatment efficiency of the medical personnel are improved.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and those skilled in the art can also obtain other drawings according to the drawings without creative efforts.
Fig. 1 is a schematic structural diagram of an interventional imaging system according to an embodiment of the present invention;
fig. 2 is a schematic structural diagram of a visible light-terahertz imaging fiber bundle in an interventional imaging system according to an embodiment of the present invention;
fig. 3 is a schematic diagram of a complete structure of an interventional imaging system according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the embodiments of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience in describing the embodiments of the present invention and simplifying the description, but do not indicate or imply that the referred devices or elements must have specific orientations, be configured in specific orientations, and operate, and thus, should not be construed as limiting the embodiments of the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.
In the description of the embodiments of the present invention, it should be noted that, unless explicitly stated or limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. Specific meanings of the above terms in the embodiments of the present invention can be understood in specific cases by those of ordinary skill in the art.
Fig. 1 is a schematic structural diagram of an interventional imaging system according to an embodiment of the present invention. As shown in fig. 1, an interventional imaging system provided by an embodiment of the present invention includes: the device comprises a light source unit 1, a beam shaping unit 2, a visible light-terahertz imaging optical fiber bundle 3 and an imaging unit 4; the light source unit 1 includes a terahertz source for emitting terahertz waves and a visible light source for emitting visible light.
The beam shaping unit 2 is used for collimating the terahertz waves and the visible light and shaping the terahertz waves to generate annular terahertz waves.
Fig. 2 is a schematic structural diagram of a visible light-terahertz imaging fiber bundle in an interventional imaging system according to an embodiment of the present invention. As shown in fig. 2, the visible light-terahertz imaging fiber bundle 3 includes an outer layer and an inner layer, the outer layer is an annular terahertz imaging fiber bundle 32 formed by bundling terahertz optical fibers, the inner layer is a visible light imaging fiber bundle 31 formed by bundling visible light optical fibers, and the inner diameter of the annular terahertz imaging fiber bundle 32 matches with the outer diameter of the visible light imaging fiber bundle 31; the visible light imaging optical fiber bundle 31 is used for receiving the collimated visible light and outputting the received visible light to an imaging target, and the annular terahertz imaging optical fiber bundle 31 is used for receiving the annular terahertz wave and outputting the received annular terahertz wave to the imaging target 5; the visible light imaging fiber bundle 31 is further configured to receive visible light reflected by the imaging target 5 and output the received visible light to the imaging unit 4, and the annular terahertz imaging fiber bundle 32 is further configured to receive annular terahertz waves reflected by the imaging target 5 and output the received annular terahertz waves to the imaging unit 4.
The imaging unit 4 is configured to receive the visible light output by the visible light imaging fiber bundle 31 and the annular terahertz wave output by the annular terahertz imaging fiber bundle 32, and perform imaging based on the received visible light and the annular terahertz wave.
Specifically, the terahertz source in the embodiment of the present invention may be a quantum cascade laser, a light source based on a laser nonlinear crystal difference frequency, or a light source based on a femtosecond laser photoconductive switch, which is not specifically limited in the embodiment of the present invention.
The beam shaping unit 2 is used for collimating the terahertz waves and the visible light, and shaping the terahertz waves to generate annular terahertz waves. The generated annular terahertz waves can have adjustable orbital angular momentum, so that the sensitivity of terahertz imaging can be improved. The visible light and the annular terahertz wave after passing through the beam shaping unit 2 can be mixed into a mixed beam, and the mixed beam consists of the visible light on the inner side and the annular terahertz wave on the outer side.
The cross section of the visible light-terahertz imaging optical fiber bundle 3 is circular, and comprises an outer layer and an inner layer, the annular terahertz imaging optical fiber bundle 32 on the outer layer is formed by bundling terahertz optical fibers, the number of the terahertz optical fibers and the arrangement number of the terahertz optical fibers in the radial direction of the visible light-terahertz imaging optical fiber bundle 3 can be set according to needs, and the number is not specifically set in the embodiment of the invention. The visible light imaging fiber bundle 31 in the inner layer is formed by bundling visible light fibers, and the number of the visible light fibers and the number of the arrangement layers of the visible light fibers in the radial direction of the visible light-terahertz imaging fiber bundle 3 may be set according to the need, which is not specifically described in the embodiment of the present invention.
It should be noted that the inner diameter of the annular terahertz imaging fiber bundle 32 matches the outer diameter of the visible light imaging fiber bundle 31, that is, the annular terahertz imaging fiber bundle 32 is coaxial with the visible light imaging fiber bundle 31, so that the visible light and the annular terahertz wave output by the beam shaping unit 2 can respectively enter the visible light imaging fiber bundle 31 and the annular terahertz imaging fiber bundle 32, and are irradiated on the target 5 without mutual influence. The visible light imaging fiber bundle 31 is configured to receive the collimated visible light output by the beam shaping unit 2 and output the received visible light to an imaging target 5, where the imaging target 5 may be a tissue to be imaged in a patient. The annular terahertz imaging fiber bundle 31 is used to receive the annular terahertz waves generated and output by the beam shaping unit 2 and output the received annular terahertz waves onto the imaging target 5. Because the inner diameter of the annular terahertz imaging fiber bundle 32 is matched with the outer diameter of the visible light imaging fiber bundle 31, the light spot of the visible light on the imaging target 5 is located in the light spot of the annular terahertz wave on the imaging target 5, and the two light spots are not mutually influenced.
The imaging target 5 respectively reflects the visible light and the annular terahertz wave irradiated thereon, and respectively reflects back into the visible light imaging optical fiber bundle 31 and the annular terahertz imaging optical fiber bundle 32, the visible light reflected by the imaging target 5 is received by the visible light imaging optical fiber bundle 31 and the received visible light is output to the imaging unit 4, and the annular terahertz wave reflected by the imaging target 5 is received by the annular terahertz imaging optical fiber bundle 32 and the received annular terahertz wave is output to the imaging unit 4.
Finally, the imaging unit 4 receives the visible light output by the visible light imaging fiber bundle 31 and the annular terahertz wave output by the annular terahertz imaging fiber bundle 32, and images according to the received visible light and the annular terahertz wave to obtain a visible light imaging result and a terahertz wave imaging result respectively, where the visible light imaging result is a visible light image and the terahertz wave imaging result is a terahertz image.
The interventional imaging system provided by the embodiment of the invention comprises a light source unit, a light beam shaping unit, a visible light-terahertz imaging optical fiber bundle and an imaging unit; the light source unit comprises a terahertz source and a visible light source, and the beam shaping unit is used for collimating terahertz waves and visible light and shaping the terahertz waves to generate annular terahertz waves. The method comprises the steps of transmitting annular terahertz waves through an annular terahertz imaging fiber bundle in a visible light-terahertz imaging fiber bundle, transmitting visible light through the visible light imaging fiber bundle, finally receiving the visible light reflected by an imaging target and the annular terahertz waves through an imaging unit respectively, and imaging according to the received visible light and the annular terahertz waves. The visible light-terahertz imaging optical fiber bundle and the imaging unit can safely and harmlessly realize the joint synchronous imaging of the interventional visible light and the terahertz wave, and synchronously obtain the visible light imaging result and the terahertz imaging result, so that on one hand, the health hidden dangers such as radiation and the like possibly brought by the traditional imaging mode are avoided, on the other hand, medical personnel can compare the terahertz image with the visible light image, the contrast, readability and accuracy of the in-vivo interventional imaging result are further improved, the medical personnel are assisted to identify the lesion area of the imaging target, the identification effect of the imaging target is improved, the misdiagnosis possibly brought by the single imaging result in the prior art is reduced, and the diagnosis and treatment efficiency of the medical personnel are improved.
Taking the imaging target of glia as an example, brain glioma is a tumor generated due to glial cytopathy, and has high malignancy and high mortality. In conventional medical observation and diagnosis, brain glioma grows in a diffuse infiltration manner, the boundary between the color, the shape and the texture of the brain glioma and surrounding brain cells is not obvious, and the boundary definition is a difficult point in surgical treatment. The interventional imaging system provided by the embodiment of the invention synchronously obtains the visible light imaging result and the terahertz imaging result, and compared with the normal tissue, the brain glioma tumor tissue has obvious difference in interstitial water, cell density and spatial arrangement thereof, and the tumor tissue has stronger terahertz absorption, so that the signal amplitudes of terahertz reflection imaging of the normal tissue and the tumor tissue are different, and the boundary of the brain glioma and the normal tissue can be effectively distinguished by combining the visible light imaging result.
On the basis of the above embodiment, in the interventional imaging system provided in the embodiment of the present invention, the imaging unit includes a terahertz camera and a visible light camera;
the visible light camera is used for receiving the visible light output by the visible light imaging optical fiber bundle and imaging based on the received visible light;
the terahertz camera is specifically used for receiving the annular terahertz waves output by the annular terahertz imaging fiber bundle and imaging based on the received annular terahertz waves.
Specifically, the imaging unit in the embodiment of the present invention specifically includes a terahertz camera and a visible light camera, and the visible light output by the visible light imaging fiber bundle and the annular terahertz wave output by the annular terahertz imaging fiber bundle are respectively received by the visible light camera and the terahertz camera, and are imaged according to the received visible light and the annular terahertz wave, so as to obtain a visible light image and a terahertz image.
In the embodiment of the invention, the visible light image and the terahertz image are obtained by the terahertz camera and the visible light camera respectively, so that the acquisition processes of the two images are simplified.
On the basis of the above embodiments, the interventional imaging system provided in the embodiments of the present invention further includes: a first beam splitter;
the first spectroscope is arranged on a light path between the visible light-terahertz imaging optical fiber bundle and the imaging unit, and the first spectroscope is used for separating a path of visible light output by the visible light imaging optical fiber bundle in the visible light-terahertz imaging optical fiber bundle from a path of annular terahertz waves output by the annular terahertz imaging optical fiber bundle.
Specifically, in the embodiment of the invention, the path separation is performed before the visible light and the annular terahertz wave are transmitted to the imaging unit through the first spectroscope, so that the visible light and the annular terahertz wave are respectively transmitted to the terahertz camera and the visible light camera in the imaging unit to be respectively imaged.
In the embodiment of the invention, the first spectroscope is introduced, so that the terahertz camera and the visible light camera can be independently imaged, and the mutual influence of visible light and annular terahertz waves during imaging is avoided.
On the basis of the above embodiment, in the interventional imaging system provided in the embodiment of the present invention, the beam shaping unit specifically includes a first optical lens, a second optical lens, a spiral phase plate, and a pyramid lens;
the terahertz waves sequentially pass through the first optical lens, the spiral phase plate and the pyramid lens to generate the annular terahertz waves;
the visible light is collimated by the second optical lens.
Specifically, in the embodiment of the present invention, the beam shaping unit specifically includes a first optical lens, a second optical lens, a spiral phase plate, and a pyramid lens, and the terahertz waves are shaped by the first optical lens, the spiral phase plate, and the pyramid lens to generate parallel or approximately parallel annular terahertz waves. And shaping the visible light through a second optical lens to generate parallel visible light.
In the embodiment of the invention, the shaping processing of the terahertz waves and the visible light is respectively realized through different devices in the beam shaping unit, so that the mutual influence of the visible light and the annular terahertz waves during the shaping processing is avoided.
On the basis of the above embodiment, in the interventional imaging system provided in the embodiment of the present invention, the annular terahertz wave is specifically a high-order bessel terahertz beam with orbital angular momentum.
Specifically, in the embodiment of the invention, the spiral phase plate and the pyramid lens are introduced into the beam shaping unit, so that the annular terahertz wave generated after shaping is specifically a high-order bessel terahertz beam with orbital angular momentum, and by adjusting the spiral phase plate and the pyramid lens, the orbital angular momentum of the high-order bessel terahertz beam can be adjusted, the imaging sensitivity of the terahertz wave can be improved, and the imaging quality can be improved.
On the basis of the above embodiment, in the interventional imaging system provided in the embodiment of the present invention, an optical path distance between the pyramid lens and the terahertz camera is less than or equal to a bessel distance of the high-order bessel terahertz light beam.
Specifically, in the embodiment of the invention, the optical path distance between the pyramid lens and the terahertz camera is limited to be less than or equal to the bessel distance of the high-order bessel terahertz light beam, so that the high-order bessel terahertz light beam generated after shaping processing by the light beam shaping unit is parallel light beam or approximately parallel light beam, the annular terahertz wave and the parallel light have the same attribute, and the annular terahertz wave and the parallel light are conveniently mixed into a mixed light beam and input into the visible light-terahertz imaging optical fiber bundle.
On the basis of the above embodiments, the interventional imaging system provided in the embodiments of the present invention further includes: a second spectroscope and a third spectroscope;
the second spectroscope and the third spectroscope are sequentially arranged on a light path between the beam shaping unit and the visible light-terahertz imaging optical fiber beam, and the third spectroscope is positioned on the light path between the visible light-terahertz imaging optical fiber beam and the imaging unit;
the second spectroscope is used for mixing the annular terahertz wave and the collimated visible light, so that the visible light in the obtained mixed light beam is surrounded by the annular terahertz wave, and the visible light in the mixed light beam and the annular terahertz wave are coaxial;
visible light in the mixed light beam is input into the visible light imaging fiber beam through the third beam splitter, and annular terahertz waves in the mixed light beam are input into the annular terahertz imaging fiber beam through the third beam splitter;
the third spectroscope is also used for reflecting the visible light output by the visible light imaging fiber bundle and the annular terahertz wave output by the annular terahertz imaging fiber bundle to the imaging unit.
Specifically, in the embodiment of the invention, the annular terahertz wave and the collimated visible light are mixed by the second beam splitter, so that the annular terahertz wave and the collimated visible light are mixed into a mixed light beam. The visible light and the annular terahertz wave in the mixed light beam are coaxial, and the axis is the optical axis of the mixed light beam. And realizing two functions through a third beam splitter, wherein the first function is to transmit the mixed light beam, so that the mixed light beam is input into the visible light-terahertz imaging fiber bundle, specifically, the visible light in the mixed light beam is input into the visible light imaging fiber bundle, and the annular terahertz wave in the mixed light beam is input into the annular terahertz imaging fiber bundle. The second function is to reflect the visible light and the annular terahertz wave reflected by the imaging target, which are transmitted and output through the visible light-terahertz imaging optical fiber bundle, and reflect the visible light and the annular terahertz wave to the imaging unit.
In the embodiment of the invention, the second spectroscope and the third spectroscope are introduced, so that the light path between the beam shaping unit and the visible light-terahertz imaging fiber bundle and the light path between the visible light-terahertz imaging fiber bundle and the imaging unit can be shortened, the size of the whole interventional imaging system is further reduced, and the cost is reduced.
On the basis of the above embodiment, the interventional imaging system provided in the embodiment of the present invention further includes a third optical lens between the third spectroscope and the visible light-terahertz imaging fiber bundle; the third optical lens is used for converging the mixed light beam into the visible light-terahertz imaging optical fiber beam.
Specifically, in the embodiment of the invention, in order to ensure that the mixed light beam can smoothly enter the visible light-terahertz imaging optical fiber bundle, the third optical lens is introduced, so that the overall convergence effect on the mixed light beam can be realized, the size of an overall light spot is reduced, and the mixed light beam can more easily enter the visible light-terahertz imaging optical fiber bundle.
On the basis of the above embodiment, in the interventional imaging system provided in the embodiment of the present invention, each of the annular terahertz imaging fiber bundle and the visible light imaging fiber bundle has at least two layers. Namely, the inner layer of the visible light-terahertz imaging optical fiber bundle comprises M layers of visible light imaging optical fiber bundles, M is not less than 2, the outer layer of the visible light-terahertz imaging optical fiber bundle comprises P layers of annular terahertz optical fiber bundles, and P is not less than 2.
On the basis of the above embodiments, in the interventional imaging system provided in the embodiments of the present invention, the outside of the visible-terahertz imaging fiber bundle is wrapped by a flexible material layer, where the flexible material layer is made of, for example, polyethylene, polytetrafluoroethylene, polyvinyl chloride, and the like.
On the basis of the above embodiments, as shown in fig. 3, a schematic diagram of an overall structure of the interventional imaging system provided in the embodiments of the present invention is shown.
1) The terahertz source 11 emits terahertz waves;
2) the terahertz waves pass through a first optical lens 21, and are shaped by the first optical lens 21 to obtain parallel beams;
3) the shaped parallel terahertz light beam passes through the spiral phase plate 22 and then passes through the pyramid lens 23 to be changed into a hollow high-order Bessel terahertz light beam with orbital angular momentum;
4) the visible light source 12 emits visible light;
5) visible light passes through the second optical lens 24, the second optical lens 24 shapes the visible light, and the visible light is converged into parallel beams;
6) the hollow high-order Bessel terahertz light beam is reflected by the second spectroscope 25, the two light beams are coaxial after the visible light beam penetrates through the second spectroscope 25, the inner part of the mixed light beam of the hollow high-order Bessel terahertz light beam and the visible light beam is visible light, and the outer part of the mixed light beam is annular hollow terahertz light; the second spectroscope and the incident light direction form an included angle of 45 degrees;
7) a mixed beam of the hollow high-order Bessel terahertz beam and the visible beam passes through the third beam splitter 26, is focused by the third optical lens 27, and is coupled into one end of the visible light-terahertz imaging fiber bundle 3, the terahertz beam is transmitted in the outer annular terahertz imaging fiber bundle, the visible beam is transmitted in the inner visible light imaging fiber bundle, and then is emitted from the other end of the visible light-terahertz imaging fiber bundle to irradiate an imaging target;
8) the visible light and the annular terahertz wave reflected by the imaging target are collected by the visible light-terahertz imaging fiber bundle 3, return to the third optical lens 27, and are converged by the third optical lens 27 to form parallel light, which is reflected by the third beam splitter 26.
9) The reflected annular terahertz wave is reflected by the first beam splitter 28 into the terahertz camera 41, the visible light beam passes through the first beam splitter 28, and the signal is collected and imaged by the visible light camera 42.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims (10)

1. An interventional imaging system, comprising: the device comprises a light source unit, a beam shaping unit, a visible light-terahertz imaging optical fiber bundle and an imaging unit;
the light source unit comprises a terahertz source and a visible light source, the terahertz source is used for emitting terahertz waves, and the visible light source is used for emitting visible light;
the beam shaping unit is used for collimating the terahertz waves and the visible light and shaping the terahertz waves to generate annular terahertz waves;
the visible light-terahertz imaging optical fiber bundle comprises an outer layer and an inner layer, wherein the outer layer is an annular terahertz imaging optical fiber bundle formed by bundling terahertz optical fibers, the inner layer is a visible light imaging optical fiber bundle formed by bundling visible light optical fibers, and the inner diameter of the annular terahertz imaging optical fiber bundle is matched with the outer diameter of the visible light imaging optical fiber bundle; the visible light imaging optical fiber bundle is used for receiving the collimated visible light and outputting the received visible light to an imaging target, and the annular terahertz imaging optical fiber bundle is used for receiving the annular terahertz waves and outputting the received annular terahertz waves to the imaging target; the visible light imaging optical fiber bundle is also used for receiving the visible light reflected by the imaging target and outputting the received visible light to the imaging unit, and the annular terahertz imaging optical fiber bundle is also used for receiving the annular terahertz waves reflected by the imaging target and outputting the received annular terahertz waves to the imaging unit;
the imaging unit is used for receiving the visible light output by the visible light imaging optical fiber bundle and the annular terahertz wave output by the annular terahertz imaging optical fiber bundle and imaging based on the received visible light and the annular terahertz wave.
2. The interventional imaging system of claim 1, wherein the imaging unit comprises a terahertz camera and a visible light camera;
the visible light camera is used for receiving the visible light output by the visible light imaging optical fiber bundle and imaging based on the received visible light;
the terahertz camera is specifically used for receiving the annular terahertz waves output by the annular terahertz imaging fiber bundle and imaging based on the received annular terahertz waves.
3. The interventional imaging system of claim 2, further comprising: a first beam splitter;
the first spectroscope is arranged on a light path between the visible light-terahertz imaging optical fiber bundle and the imaging unit, and the first spectroscope is used for separating a path of visible light output by the visible light imaging optical fiber bundle in the visible light-terahertz imaging optical fiber bundle from a path of annular terahertz waves output by the annular terahertz imaging optical fiber bundle.
4. The interventional imaging system of claim 2, wherein the beam shaping unit comprises in particular a first optical lens, a second optical lens, a helical phase plate and a pyramid lens;
the terahertz waves sequentially pass through the first optical lens, the spiral phase plate and the pyramid lens to generate the annular terahertz waves;
the visible light is collimated by the second optical lens.
5. The interventional imaging system of claim 4, characterized in that the ring-like terahertz wave is in particular a higher order Bessel terahertz beam with orbital angular momentum.
6. The interventional imaging system of claim 5, wherein an optical path distance between the pyramid lens and the terahertz camera is less than or equal to a Bezier distance of the higher order Bezier terahertz beam.
7. The interventional imaging system of claim 1, further comprising: a second spectroscope and a third spectroscope;
the second spectroscope and the third spectroscope are sequentially arranged on a light path between the beam shaping unit and the visible light-terahertz imaging optical fiber beam, and the third spectroscope is positioned on the light path between the visible light-terahertz imaging optical fiber beam and the imaging unit;
the second spectroscope is used for mixing the annular terahertz wave and the collimated visible light, so that the visible light in the obtained mixed light beam is surrounded by the annular terahertz wave, and the visible light in the mixed light beam and the annular terahertz wave are coaxial;
visible light in the mixed light beam is input into the visible light imaging fiber beam through the third beam splitter, and annular terahertz waves in the mixed light beam are input into the annular terahertz imaging fiber beam through the third beam splitter;
the third beam splitter is further configured to reflect the visible light output by the visible light imaging fiber bundle and reflected by the imaging target, and the annular terahertz wave output by the annular terahertz imaging fiber bundle and reflected by the imaging target onto the imaging unit.
8. The interventional imaging system of claim 7, further comprising a third optical lens between the third beam splitter and the visible-terahertz imaging fiber bundle; the third optical lens is used for converging the mixed light beam into the visible light-terahertz imaging optical fiber beam.
9. The interventional imaging system of any one of claims 1-8, wherein the annular terahertz imaging fiber bundle and the visible light imaging fiber bundle each have at least two layers.
10. The interventional imaging system of any one of claims 1-8, wherein the visible-terahertz imaging fiber bundle is externally wrapped by a layer of flexible material.
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1412595A (en) * 2002-12-02 2003-04-23 中国科学院上海技术物理研究所 Pupil split spectroscopic double-band optical imaging system
CN1457428A (en) * 2001-02-28 2003-11-19 图像研究公司 Imaging fluorometer for time resolved fluorescence
CN108392263A (en) * 2011-01-19 2018-08-14 弗拉克泰尔实验室公司 Apparatus and method for tissue treatment
CN109222911A (en) * 2018-10-29 2019-01-18 中国科学院西安光学精密机械研究所 A kind of miniature system for insertion type illumination
CN109567954A (en) * 2017-09-28 2019-04-05 通用电气公司 The workflow auxiliary system and method for image bootstrap

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2352512B (en) * 1999-07-23 2002-03-13 Toshiba Res Europ Ltd A radiation probe and detecting tooth decay
US7087902B2 (en) * 2002-04-19 2006-08-08 Rensselaer Polytechnic Institute Fresnel lens tomographic imaging
JP2011203016A (en) * 2010-03-24 2011-10-13 Olympus Corp Observation device
WO2012170401A2 (en) * 2011-06-06 2012-12-13 Percuvision, Llc Sensing catheter emitting radiant energy
CN105158196B (en) * 2015-05-12 2017-09-29 上海理工大学 A kind of THz wave 3D rendering acquisition methods and system
CN205378011U (en) * 2016-02-15 2016-07-06 诺特迪瑞(苏州)信息技术有限公司 Image synchronizer
CN113504203A (en) * 2016-11-01 2021-10-15 韩国食品研究院 High-resolution terahertz wave light-gathering module
CN107095673B (en) * 2017-05-24 2018-03-13 西北核技术研究所 A kind of reflective tumor imaging method and system in real time
US10234383B2 (en) * 2017-06-20 2019-03-19 Konica Minolta Laboratory U.S.A., Inc. Terahertz spectral imaging system and security surveillance system employing the same
KR20190036327A (en) * 2017-09-27 2019-04-04 주식회사 소모에너지엔테크놀러지 Apparatus and method of blending multiple image for tera hertz and visible bend
CN109900646A (en) * 2019-04-04 2019-06-18 深圳市太赫兹科技创新研究院有限公司 Optical fiber type bimodal imaging system and optical fiber type bimodal imaging method
CN110376135B (en) * 2019-08-08 2020-07-21 中国人民解放军军事科学院国防科技创新研究院 Terahertz super-resolution microscopic imaging system
CN110940996A (en) * 2019-12-11 2020-03-31 西安交通大学 Terahertz and visible light based imaging device, monitoring system and imaging method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1457428A (en) * 2001-02-28 2003-11-19 图像研究公司 Imaging fluorometer for time resolved fluorescence
CN1412595A (en) * 2002-12-02 2003-04-23 中国科学院上海技术物理研究所 Pupil split spectroscopic double-band optical imaging system
CN108392263A (en) * 2011-01-19 2018-08-14 弗拉克泰尔实验室公司 Apparatus and method for tissue treatment
CN109567954A (en) * 2017-09-28 2019-04-05 通用电气公司 The workflow auxiliary system and method for image bootstrap
CN109222911A (en) * 2018-10-29 2019-01-18 中国科学院西安光学精密机械研究所 A kind of miniature system for insertion type illumination

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